Updated on 2025/08/22

Information

 

写真a

 
KAWAZOE TETSURO
 
Organization
Kyushu University Hospital Gastrointestinal Surgery (2) Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
消化器癌に関する基礎的、臨床的研究
External link

Research Areas

  • Life Science / Digestive surgery

Degree

  • Doctor of Philosophy (Medical Science)

Research History

  • Kyushu University Kyushu University Hospital Gastrointestinal Surgery (2)  Assistant Professor 

    2024.10 - Present

Education

  • Kyushu University    

    2008.4 - 2014.3

Awards

  • 日本外科学会 第2回優秀論文賞

    2020.4   日本外科学会  

  • 第57回日本癌治療学会 最優秀演題賞

    2019.10   日本癌治療学会  

Papers

  • A 14-Gene Panel for Predicting Colorectal Cancer Recurrence Using Circulating Tumor DNA in Different Testing Conditions Reviewed

    Hisamatsu, Y; Ando, K; Kudo, K; Nakanishi, R; Kawazoe, T; Zaitsu, Y; Kusumoto, T; Hata, T; Kagawa, Y; Yoshizumi, T; Ashida, N; Niiro, H; Hirose, T; Oki, E

    CANCER SCIENCE   2025.6   ISSN:1347-9032 eISSN:1349-7006

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    Detecting minimal residual disease after surgery is critical for assessing colorectal cancer recurrence risk. Traditional methods, including histology and carcinoembryonic antigen testing, have limited sensitivity. As circulating tumor DNA has emerged as a promising minimal residual disease biomarker, we evaluated circulating tumor DNA detection using a sensitive, targeted 14-gene panel, the Sysmex Plasma-Safe-SeqS colorectal cancer assay, in resectable colorectal cancer cases. We enrolled 46 Japanese patients with preoperatively diagnosed stage II colorectal cancer who underwent surgery at three institutions. Plasma samples were collected pre- and postoperatively. Tumor-informed, plasma-informed, and tumor-naive Plasma-Safe-SeqS colorectal cancer assays were performed. Patients were followed for a median of 1169 (range 148–1476) days using clinical assessments and computed tomography scans. Variants in tumor tissue were detected in 45 of 46 cases (98%). Preoperative circulating tumor DNA was detected in 32 (70%) and postoperative circulating tumor DNA in 16 (35%) patients. Postoperative circulating tumor DNA predicted recurrence with 33%, 38%, and 25% of positive percent agreement for tumor-informed, plasma-informed, and tumor-naive assays, respectively. The tumor-naive assay detected more postoperative circulating tumor DNA-positive cases than the others. As the tumor-naive approach does not require preoperative genetic profiling, it offers significant advantages in cost and ease of implementation in routine clinical practice. Further large-scale studies are warranted to optimize detection strategies.

    DOI: 10.1111/cas.70114

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  • Squamous cell carcinoma arising in sacrococcygeal teratoma in an adult: A case report Reviewed

    Tanaka, Y; Nakanishi, R; Hazama, H; Mori, T; Kawazoe, T; Kudou, K; Zaitsu, Y; Hisamatsu, Y; Ando, K; Oki, E; Aishima, S; Oda, Y; Yoshizumi, T

    HUMAN PATHOLOGY REPORTS   40   2025.6   eISSN:2772-736X

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    Sacrococcygeal teratomas (SCT) with malignant transformation to squamous cell carcinoma are extremely rare, with only few cases reported in the literature. Herein, we report on a case of a primary sacrococcygeal mature cystic teratoma with malignant transformation into a squamous cell carcinoma. A 53-year-old woman presented with dysuria and lower abdominal pain caused by a huge SCT. Computed tomography (CT), magnetic resonance imaging, and positron emission tomography/CT findings were suggestive of SCT with malignant transformation. The treatment involved robotic-assisted laparoscopic abdominoperineal resection and bilateral lymph node dissection. Histopathology revealed squamous cell carcinoma within the teratoma. Postoperatively, the patient underwent six cycles of paclitaxel-carboplatin chemotherapy and showed no signs of recurrence during the 1-year follow-up.

    DOI: 10.1016/j.hpr.2025.300773

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  • Polo-Like Kinase 1 Expression in Colorectal Cancer: Association With RAS Mutations. Reviewed

    Tanaka Y, Oki E, Nakanishi R, Kawazoe T, Kudo K, Zaitsu Y, Hisamatsu Y, Ando K, Oda Y, Yoshizumi T

    Cancer science   116 ( 7 )   2032 - 2039   2025.5   ISSN:1347-9032 eISSN:1349-7006

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    Polo-like kinase 1 (PLK1) controls mitotic spindle formation and cytokinesis. However, its role as a predictive biomarker for treatment outcomes in colorectal cancer (CRC) remains underexplored, particularly in the context of RAS mutations. We retrospectively analyzed the relationships among PLK1 expression, clinicopathological factors, and survival in 225 patients who underwent CRC surgery. We also analyzed the relationship between PLK1 expression and survival after adjuvant chemotherapy and how RAS mutation influenced the prognosis. We found that PLK1 expression was significantly correlated with histopathology (p < 0.0001) and perineural invasion (p = 0.005). The high PLK1 expression group tended to have a worse prognosis in terms of relapse-free survival than the low expression group for all patients (p = 0.060) and patients with stage III disease (p = 0.055). In patients who received adjuvant chemotherapy for stage III CRC, high PLK1 expression was the only poor prognostic factor for relapse-free survival (p = 0.01), and those with mutated RAS had a significantly poorer prognosis than those with wild-type RAS (p = 0.027). In patients with CRC, high PLK1 expression was associated with poor survival after adjuvant chemotherapy, and there was potential involvement of the RAS mutation.

    DOI: 10.1111/cas.70088

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  • Three Cases of Surgery for Colorectal Cancer in Patients with Severe Motor and Intellectual Disabilities Reviewed

    Ebata Yuho, Nakanishi Ryota, Kawazoe Tetsuro, Kudo Kensuke, Zaitsu Yoko, Nakashima Yuichiro, Ando Koji, Oki Eiji, Ishigami Kosei, Aishima Shinichi, Yoshizumi Tomoharu

    The Japanese Journal of Gastroenterological Surgery   58 ( 5 )   295 - 303   2025.5   ISSN:03869768 eISSN:13489372

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    Language:Japanese   Publisher:The Japanese Society of Gastroenterological Surgery  

    <p>Case 1: A 44-year-old woman with Rett syndrome and chronic respiratory failure, who was dependent on mechanical ventilation and gastrostomy, was diagnosed with ascending colon cancer. The patient underwent laparoscopic right hemicolectomy and was discharged to her care facility on postoperative day 7 without complications. Case 2: A 61-year-old man with cerebral palsy, epilepsy, asthma, and a history of bladder stones was diagnosed with transverse colon cancer. The patient underwent laparoscopic transverse colectomy and gastrostomy. Postoperatively, he developed a urinary tract infection, but was discharged to his care facility on postoperative day 8. Case 3: A 47-year-old woman with chromosome 21 abnormality, epilepsy, and asthma, who was dependent on gastrostomy, was diagnosed with sigmoid colon cancer. The patient underwent a laparoscopic Hartmann procedure. Her postoperative course was complicated by paralytic ileus, epileptic seizures, and pneumonia, but she was discharged to her care facility on postoperative day 30. We report these three cases as examples of patients with severe motor and intellectual disabilities who underwent radical laparoscopic surgery for colorectal cancer. Such patients are prone to severe complications due to environmental changes; therefore, perioperative management and coordination with care facilities are essential.</p>

    DOI: 10.5833/jjgs.2024.0065

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  • The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer(タイトル和訳中) Reviewed

    Tanaka Yasushi, Hu Qingjiang, Kawazoe Tetsuro, Tajiri Hirotada, Nakanishi Ryota, Zaitsu Yoko, Nakashima Yuichiro, Ota Mitsuhiko, Oki Eiji, Oda Yoshinao, Yoshizumi Tomoharu

    International Journal of Clinical Oncology   30 ( 2 )   330 - 339   2025.2   ISSN:1341-9625

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    Language:English   Publisher:シュプリンガー・ジャパン(株)  

    マクロファージに発現する抑制性受容体であるシグナル調節タンパク質α(SIRPα)の発現が胃癌に及ぼす影響と、免疫チェックポイント阻害薬(ICI)の効果との関連を後ろ向きに検討した。2012年1月から2015年12月までに当院で原発性胃癌に対して外科的切除を受けた患者137例と、2017年から2020年までに切除不能な進行性胃癌に対してニボルマブ治療を受けた患者19例を対象とした。胃切除群137例をSIRPα高発現群(平均68.9±11.8歳)とSIRPα低発現群(平均67.0±11.6歳)で比較した。その結果、SIRPα高発現は、進行した腫瘍浸潤、遠隔転移、無再発生存期間および全生存期間の不良と相関していた。SIRPαの発現はマクロファージやCD8+T細胞の浸潤、PD-L1の発現とも有意に関連していた。ICI治療を受けた患者では、SIRPαの高発現はニボルマブ導入後の全生存期間の延長と関連していた。さらに、末梢血単核球およびTHP-1細胞をin vitroでIFN-γ刺激した。その結果、細胞表面でのSIRPα発現が上昇したことから、SIRPαの高発現は活発な免疫微小環境を反映している可能性が示唆された。以上より、SIRPα発現は、CD47-SIRPα経路の阻害を介した胃癌の予後不良因子であるだけでなく、胃癌におけるICI療法の有効性にも関与している可能性があった。

  • The clinical significance of signal regulatory protein alpha expression in the immune environment of gastric cancer Reviewed

    Tanaka, Y; Hu, QJ; Kawazoe, T; Tajiri, H; Nakanishi, R; Zaitsu, Y; Nakashima, Y; Ota, M; Oki, E; Oda, Y; Yoshizumi, T

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   30 ( 2 )   330 - 339   2025.2   ISSN:1341-9625 eISSN:1437-7772

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    Background: Signal regulatory protein alpha (SIRPα) inhibits phagocytosis by macrophages by interacting with CD47. Despite its known role in various cancers, the clinical significance of SIRPα in gastric cancer (GC) remains unclear. This study aimed to elucidate the clinical implications of SIRPα in GC, exploring its relevance to immunotherapy efficacy and the tumor microenvironment. Methods: Two cohorts were studied: a gastrectomy cohort (137 patients) and an immune checkpoint inhibitor (ICI)-treated cohort (19 patients with unresectable advanced GC who received nivolumab). Immunohistochemistry was used to assess SIRPα, CD80, CD163, CD8, and PD-L1 expressions. Kaplan–Meier curves and Cox models were used to analyze the clinical outcomes. In vitro experiments used peripheral blood mononuclear cells and THP-1 macrophage cell lines to examine SIRPα responses to interferon-γ (IFN-γ). Results: In the gastrectomy cohort, high SIRPα expression correlated with advanced tumor invasion, distant metastasis, and poor recurrence-free and overall survival. SIRPα expression was also significantly associated with macrophage and CD8 + T cells infiltration and PD-L1 expression. In the ICI-treated cohort, high SIRPα expression was associated with better overall survival after nivolumab induced. Moreover, in vitro IFN-γ stimulation upregulated SIRPα expression on monocytes in peripheral blood mononuclear cells and THP-1 cells, suggesting high SIRPα expression may reflect an active immune microenvironment. Conclusion: SIRPα expression is not only a poor prognostic factor for GC, possibly through inhibition of the CD47-SIRP⍺ pathway, but may also be involved in the efficacy of ICI therapy in GC.

    DOI: 10.1007/s10147-024-02666-1

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  • Preoperative CT lymph node size as a predictor of nodal metastasis in resectable Colon cancer: a retrospective study of 694 patients Reviewed

    Kawazoe, T; Nakanishi, R; Ando, K; Zaitsu, Y; Kudou, K; Nakashima, Y; Oki, E; Yoshizumi, T

    BMC GASTROENTEROLOGY   25 ( 1 )   18   2025.1   eISSN:1471-230X

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    Purpose: This study aimed to investigate the efficacy of measuring lymph node size on preoperative CT imaging to predict pathological lymph node metastasis in patients with colon cancer to enhance diagnostic accuracy and improve treatment planning by establishing more reliable assessment methods for lymph node metastasis. Methods: We retrospectively analyzed 1,056 patients who underwent colorectal resection at our institution between January 2004 and March 2020. From this cohort, 694 patients with resectable colon cancer were included in the study. We analyzed the relationship between lymph node size on preoperative CT imaging and lymph node metastasis identified on postoperative pathological examination. Results: The optimal cutoff values for the maximum long diameter and short diameter of regional lymph nodes on preoperative CT were identified as 6.5 mm and 5.5 mm, respectively, with an AUC of 0.7794 and 0.7755, respectively. Notably, the predictive accuracy varied by tumor location. Higher cutoff values were observed in the right-sided colon (maximum long diameter: 7.7 mm, maximum short diameter: 5.9 mm) compared to the left-sided colon (maximum long diameter: 5.8 mm, maximum short diameter: 5.2 mm). Conclusion: Lymph node size on preoperative CT is a significant predictor of pathological lymph node metastasis in colon cancer. Notably, the optimal cutoff values for predicting lymph node metastasis vary depending on the specific region within the colon.

    DOI: 10.1186/s12876-025-03602-x

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  • Long-Term Survival after Choroidal Metastasis Following Colorectal Cancer Surgery: A Case Report Reviewed

    Ryujin Keiichiro, Kawazoe Tetsuro, Sato Shota, Otake Akihiko, Shin Yuki, Tajiri Hirotada, Zaitsu Yoko, Ando Koji, Oki Eiji, Yoshizumi Tomoharu

    Surgical Case Reports   11 ( 1 )   n/a   2025   ISSN:2198-7793 eISSN:21987793

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    Authorship:Corresponding author   Language:English   Publisher:Japan Surgical Society  

    <p><b>INTRODUCTION:</b> Choroidal metastasis from colorectal cancer is extremely rare, accounting for approximately only 4% of all choroidal metastases. However, with the increasing incidence and improved survival rates of colorectal cancer, the importance of diagnosing and treating ocular metastases is growing. We report a case of choroidal metastasis from colorectal cancer and review the relevant literature.</p><p><b>CASE PRESENTATION:</b> A 67-year-old man underwent curative surgery and adjuvant chemotherapy for ascending colon cancer. Two years later, pulmonary recurrence was detected and surgically resected. At 2 years and 5 months postoperatively, he developed visual impairment in the left eye, which led to the diagnosis of choroidal metastasis. A combination of systemic chemotherapy and local radiotherapy resulted in tumor shrinkage and relief of ocular pain. With additional local treatments administered in response to subsequent recurrences, the patient achieved long-term survival—5 years and 6 months after surgery and 3 years after the diagnosis of choroidal metastasis. A review of 22 reported cases of choroidal metastasis from colorectal cancer published since 2000 revealed that most patients had multi-organ metastases at the time of diagnosis. The average survival following the diagnosis of ocular metastasis was 10.4 months, indicating a poor prognosis. By contrast, local treatments—such as radiotherapy and intravitreal injections—contributed to symptom relief and the maintenance of quality of life. This case represents a valuable example of long-term survival achieved through combined local therapies.</p><p><b>CONCLUSIONS:</b> Although choroidal metastasis from colorectal cancer is rare, clinical management should consider the possibility of ocular involvement. A multidisciplinary approach combining systemic therapy with local treatments is essential for maintaining quality of life and prolonging survival.</p>

    DOI: 10.70352/scrj.cr.25-0317

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  • Duodenal Brunner's gland hamartoma resected using laparoscopic and endoscopic cooperative surgery: A case report Reviewed

    Sato, S; Kawazoe, T; Tanaka, Y; Ota, M; Oki, E; Yoshizumi, T

    INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS   125   110617   2024.12   ISSN:2210-2612

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    Introduction and importance: Brunner's gland hamartoma is a rare benign duodenal tumor. Resection is recommended for large or symptomatic lesions, but conventional pancreaticoduodenectomy and other procedures can be overly invasive for the lesion. We report a case of Brunner's gland hamartoma resected using laparoscopic and endoscopic cooperative surgery (LECS). Case presentation: A 51-year-old woman was referred to our hospital with an asymptomatic duodenal tumor that had increased in size. A submucosal tumor was found on the anterior wall of the duodenal bulb during a detailed examination, and surgery was performed because the tumor was large (2 cm). In order to optimally resect the tumor, duodenal LECS (D-LECS) was selected. The resection line was determined while checking the base of the lesion with an intraoperative endoscope, and after the lesion was resected, the mucosal defect was closed using laparoscopic manipulation. Histopathological evaluation revealed Brunner's gland hyperplasia and mixed smooth muscle bundles, and the lesion was diagnosed as a Brunner's gland hamartoma. The surgery was completed without any problems, and the patient made a full recovery after the surgery with no complications such as stenosis, and no recurrence was observed. Clinical discussion: With D-LECS, the lesion can be resected without excess or deficiency, and the incision can be sutured with minimal invasiveness. D-LECS is an effective method as a treatment option for Brunner's gland hamartoma. Conclusion: We herein report a case of Brunner's gland hamartoma treated safely with a minimally invasive surgical technique: D-LECS.

    DOI: 10.1016/j.ijscr.2024.110617

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  • RAS mutant transverse colon cancer with multiple liver metastases achieving long-term disease-free survival with postoperative maintenance therapy with aflibercept plus FOLFIRI and four repeated radical resections: a case report Reviewed

    Tanaka, Y; Nakanishi, R; Sato, S; Otake, A; Ryujin, K; Ikeda, S; Ebata, Y; Harima, T; Natsugoe, K; Yoshiyama, T; Shin, Y; Kawazoe, T; Kudo, K; Zaitsu, Y; Hisamatsu, Y; Ando, K; Nakashima, Y; Itoh, S; Oki, E; Oda, Y; Yoshizumi, T

    SURGICAL CASE REPORTS   10 ( 1 )   231   2024.10   ISSN:2198-7793

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  • Impact of surgical proximal and distal margins on the recurrence of resectable colon cancer: a single-center observational cohort study Reviewed

    Kawazoe, T; Toyota, S; Nakanishi, R; Tajiri, H; Zaitsu, Y; Nakashima, Y; Ota, M; Oki, E; Yoshizumi, T

    SURGERY TODAY   54 ( 10 )   1248 - 1254   2024.10   ISSN:0941-1291 eISSN:1436-2813

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    Purpose: Few studies have investigated the impact of the surgical proximal and distal margins on colon cancer recurrence. We conducted this study to investigate the effect of resection margins on the prognosis of resectable colon cancer. Methods: We analyzed data on 1458 patients who underwent colorectal resection in our institute between January, 2004 and March, 2020, including 579 patients with resectable colon cancer. The association between the resection margin and recurrence for each oncological status was assessed and the value of the resection length that influenced recurrence was analyzed. Results: Patients who had pT4 colon cancer with margins of more than 7 cm had a trend of fewer recurrences and longer relapse-free survival (RFS) than those with colon cancer of other stages (P = 0.033; hazard ratio [HR], 0.42; 95% confidence interval [CI], 0.20–0.89). Multivariate analysis identified a margin of < 7 cm as an independent risk factor for RFS in patients with pT4 colon cancer (P = 0.023; HR, 2.65; 95% CI 1.013–6.17). No correlation was found between resection margins and recurrence, depending on the extent of lymph node metastasis and tumor location. Conclusion: A resection margin of at least 7 cm should be maintained for patients with pT4 colon cancer.

    DOI: 10.1007/s00595-024-02836-8

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  • Neoadjuvant Chemotherapy in Patients With T4b or Obstructive Colon Cancer: A Single Center Retrospective Cohort Study Reviewed

    Ebata, Y; Nakanishi, R; Tanaka, Y; Kawazoe, T; Tajiri, H; Zaitsu, Y; Nakashima, Y; Ota, M; Oki, E; Yoshizumi, T

    ANTICANCER RESEARCH   44 ( 3 )   1281 - 1287   2024.3   ISSN:0250-7005 eISSN:1791-7530

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    Background/Aim: The efficacy of neoadjuvant chemotherapy (NAC) for colon cancer remains unestablished. This study aimed to investigate the outcomes of NAC in patients with locally advanced T4b or obstructive T4a colon cancers (LACC). Patients and Methods: Data of patients with LACC who underwent colon surgery between 2010 and 2022 after NAC at our institution were retrospectively reviewed. Patient characteristics, surgical outcomes, tumor features, and prognosis were analyzed. Results: Among 800 patients with LACC who underwent radical resection, 11 received NAC because of cT4b or cT4a with mechanical obstruction. NAC, administered as a doublet regimen, had a median duration of three months, without grade ≥3 adverse events. R0 resection was achieved in all patients and downstaging was observed in eight patients. One patient developed a postoperative abdominal abscess, and adjuvant chemotherapy was administered to eight patients. Four patients experienced recurrence: liver metastasis in two, and local recurrence in two. Among these, three patients underwent resection of recurrent tumors. Median follow-up was 30 months. Conclusion: NAC is feasible for T4b or obstructive T4a colon cancer and may be a treatment option for LACC. Further large-scale studies are required to confirm the efficacy of NAC in these patients.

    DOI: 10.21873/anticanres.16923

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  • Preoperative Hemoglobin Level as Predictor of the Development of High-output Stoma in Rectal Cancer Surgery Reviewed International journal

    Tetsuro Kawazoe, Kippei Ohgaki, Yoshihiko Fujinaka, Huanlin Wang, Kazutoyo Morita, Ryota Nakanishi, Yoichi Ikeda

    Cancer Diagnosis and Prognosis   3 ( 6 )   667 - 672   2023.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.21873/cdp.10270.

  • Successful Treatment of Refractory Enterocutaneous Fistula After Esophagectomy Using Soft Coagulation by an Endoscopic and Percutaneous Approach: A Case Report Reviewed

    Ito S., Ohgaki K., Kawazoe T., Wang H., Okamoto Y., Adachi E., Ikeda Y.

    Anticancer Research   43 ( 6 )   2873 - 2877   2023.6   ISSN:02507005

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    Background/Aim: Anastomotic leakage (AL) is a serious complication after esophagectomy, and the refractory fistula (RF) following AL is therapeutically challenging with no optimal management strategies known. Thus, new therapeutic options are required for treating RF. Case Report: A 67-year-old man who underwent endoscopic mucosal dissection was subjected to subtotal esophagectomy and reconstruction with a gastric tube through the retrosternal route with cervical anastomosis as additional therapy. On postoperative day 5, leakage from the esophagogastric anastomosis was detected. A refractory enterocutaneous fistula (4 cm in length) developed between the esophagogastric anastomosis (the fistula opening was 1 cm approximately) and cervical skin. The RF did not heal despite the drainage of saliva, enteral nutrition, oral administration of biperiden hydrochloride for orofacial dyskinesia to rest the esophagogastric anastomosis, coagulation factor XIII transvenously, and fibrin glue injection from the opening of the fistula, probably due to difficulty in maintaining the rest of the esophagogastric anastomosis caused by orofacial dyskinesia. On postoperative day 76, soft coagulation to the fistula opening at the esophagogastric anastomosis by an endoscopic approach and to the fistula via the fistula opening at the cervical site by a percutaneous approach was performed. The post-treatment course was uneventful. The RF completely closed immediately after soft coagulation. Conclusion: Soft coagulation using endoscopic and percutaneous approaches to RF is a minimally invasive procedure and may be a useful option if the fistula opening of the anastomotic site is small and accessible endoscopically, and there are no vital organs around the fistula.

    DOI: 10.21873/anticanres.16457

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  • Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii Reviewed

    Maehara, Y; Oki, E; Ota, M; Harimoto, N; Ando, K; Nakanishi, R; Kawazoe, T; Fujimoto, Y; Nonaka, K; Kitao, H; Iimori, M; Makino, K; Takechi, T; Sagara, T; Miyadera, K; Matsuoka, K; Tsukihara, H; Kataoka, Y; Wakasa, T; Ochiiwa, H; Kamahori, Y; Tokunaga, E; Saeki, H; Yoshizumi, T; Kakeji, Y; Shirabe, K; Baba, H; Shimada, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   28 ( 5 )   613 - 624   2023.5   ISSN:1341-9625 eISSN:1437-7772

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    Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are therapeutic drugs for various other diseases. He delivered hope to patients with various diseases across the world to improve their condition. Even now, drug discovery research based on Dr. Fujii’s ideas is continuing.

    DOI: 10.1007/s10147-023-02326-w

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  • Survival Benefits of Laparoscopic Gastrectomy in Elderly Patients With Gastric Cancer: Focusing on Preoperative Nutritional and Inflammatory Status Reviewed

    Ito S., Ohgaki K., Kawazoe T., Sato S., Ikeda S., Kakizoe K., Wang H., Nakamura T., Maehara S., Adachi E., Ikeda Y., Maehara Y.

    Anticancer Research   43 ( 5 )   2055 - 2067   2023.5   ISSN:02507005

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    Background/Aim: Laparoscopic gastrectomy (LG) may have greater clinical benefits as a less invasive surgery for elderly patients with gastric cancer (GC). Therefore, we aimed to evaluate the survival benefit of LG in elderly patients with GC, especially focusing on preoperative comorbidities, and nutritional and inflammatory status. Patients and Methods: Data collected from 115 patients aged ≥75 years with primary GC who underwent curative gastrectomy, comprising 58 patients who underwent open gastrectomy (OG) and 57 patients who underwent LG, were retrospectively reviewed (total cohort), and 72 propensity-matched patients (matched cohort) were selected for survival analysis. The aim of the study was to determine short- and long-term outcomes, and the clinical markers to identify a population who may benefit from LG in elderly patients. Results: The complication and mortality rates as a short-term outcome in the total cohort and overall survival (OS) as a long-term outcome in the matched cohort did not differ significantly between the groups. In the total cohort, advanced tumor stage and ≥3 comorbidities were independent factors for poor prognosis in terms of OS [hazard ratio (HR)=3.73, 95% confidence interval (CI)=1.78-7.78, p<0.001 and HR=2.50, 95% CI=1.35-4.61, p<0.01, respectively]. The surgical approach was not an independent risk factor for postoperative complications (grade ≥III) and OS. In subgroup analysis of the total cohort, patients with a neutrophil-lymphocyte ratio (NLR) ≥3 in the LG group demonstrated a trend toward greater OS (HR=0.26, 95% CI=0.10-0.64, interaction p<0.05). Conclusion: LG might offer greater survival benefits than OG in frail patients such as those with high NLR.

    DOI: 10.21873/anticanres.16366

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  • 高齢のステージIVB期食道扁平上皮癌患者における免疫チェックポイント阻害薬による化学療法後のコンバージョン手術の奏効 症例報告(Successful conversion surgery following chemotherapy with an immune checkpoint inhibitor in an older adult patient with stage IVB esophageal squamous cell carcinoma: a case report) Reviewed

    Kawazoe Tetsuro, Ito Shuhei, Ohgaki Kippei, Fujinaka Yoshihiko, Funakoshi Hiroki, Otake Akihiko, Wang Huanlin, Morita Kazutoyo, Fushimi Fumiyoshi, Ikeda Yoichi

    Surgical Case Reports   9   1 of 7 - 7 of 7   2023.3

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    Language:English   Publisher:Springer Berlin Heidelberg  

    症例は80歳女性。嚥下困難を主訴に来院した。上部消化管内視鏡検査で胸部下部食道に潰瘍性病変を認め、生検で中分化型扁平上皮癌と診断した。CTで胃周囲リンパ節に加え、鎖骨上リンパ節と傍下大静脈リンパ節の腫大を認めた。PET-CTで上記のリンパ節でFDGの異常集積を認めた。以上の所見から、ステージIVB期食道扁平上皮癌(cT3N2M1 cStageIVB)と診断し、ペムブロリズマブと標準化学療法の併用療法を開始した。レジメンは3週ごとのコースで、5-FU(800mg/m2)、シスプラチン(80mg/m2)、ペムブロリズマブ(200mg)を静注した。2コース終了後に好中球減少症が発現したため、5-FUとシスプラチンの投与量を減量した。4コース終了後に原発巣と転移巣の縮小を認め、PET-CTでFDGの異常集積は見られなかった。診断をycT2N0M0 ycStageIIに変更し、コンバージョン手術の方針となった。胸腔鏡下食道亜全摘術、リンパ節郭清術、胃管再建術を施行した。術後に腫瘍細胞の遺残を認めず、組織学的完全奏効と判定した。16日後に無事退院となった。10ヵ月後の再診で再発は見られなかった。

  • Refractory splenic bleeding from splenic angiosarcoma: A case report and literature review Reviewed

    Kawazoe T., Ohgaki K., Adachi E., Ikeda Y., Fushimi F., Kakihara D.

    International Journal of Surgery Case Reports   99   2022.10   ISSN:22102612

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    Publisher:International Journal of Surgery Case Reports  

    Introduction and importance: Atraumatic splenic rupture (ASR) is a rare state that accounts for only <1 % of splenic ruptures. One of the causes of ASR is splenic neoplasm such as angiosarcoma. The treatment strategy for ASR is still unclear given the small number of cases reported in detail. Case presentation: A 75-year-old woman presenting with abdominal pain with shock was referred to our hospital. Emergency computed tomography revealed splenic rupture, and hemodynamic stabilization was obtained by emergent vascular embolization. Rebleeding occurred 27 days after the initial treatment, and splenectomy was performed. Pathologically, ASR was diagnosed as caused by splenic angiosarcoma. Clinical discussion: ASR is a very rare disease. The etiology of ASR has been reported as neoplastic, infectious, and so on. The treatment for ASR should be decided considering the etiology of ASR, hemodynamic stability, volume of blood transfusion, patient status, severity of the splenic injury, and volume of intraperitoneal bleeding. Conclusions: We experienced a very rare case of ASR, in which diagnosis was challenging and the timing of surgery was difficult to determine. When splenic rupture has an atraumatic cause, splenectomy should be considered because of the possibility of malignancy.

    DOI: 10.1016/j.ijscr.2022.107708

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  • Survival benefits of gastrectomy compared to conservative observation for older patients with resectable gastric cancer: a propensity score matched analysis Reviewed

    Ito S., Ohgaki K., Kawazoe T., Wang H., Nakamura T., Maehara S., Adachi E., Ikeda Y., Maehara Y.

    Langenbeck's Archives of Surgery   407 ( 6 )   2281 - 2292   2022.9   ISSN:14352443

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    Publisher:Langenbeck's Archives of Surgery  

    Purpose: Radical gastrectomy is considered the first choice of curative treatment for older patients with gastric cancer (GC). However, there is limited data on the survival benefits of gastrectomy for older patients with GC. Methods: This was a retrospective observational study where medical records of patients aged ≥ 75 years with clinically resectable primary GC, comprising 115 patients who underwent radical surgery (S group) and 33 patients who received conservative therapy (non-S group) (total cohort) and 44 propensity-matched patients (matched cohort), were reviewed. Survival and independent risk factors, including comorbidities and systemic nutritional and inflammatory statuses, were evaluated. Results: In the total cohort, the 5-year overall survival (OS) in the S group was significantly higher than that in the non-S group (53.7% vs 19.7%, P < 0.0001). In the matched cohort, the 3-year OS in the S group was significantly higher than that in the non-S group (59.4% vs 15.9%, P < 0.01). Multivariate analysis of the total cohort showed that no surgery was an independent prognostic factor for poor OS (hazard ratio (HR) 3.70, 95% confidence interval (CI) 1.91–7.20, P = 0.0001). In the S group in the total cohort, the multivariate analysis showed that renal disease (HR 2.51, 95% CI 1.23–5.12, P < 0.05) was an independent prognostic factor for poor OS. Conclusions: Gastrectomy for older patients improved the prognosis; however, careful patient selection is essential, especially among those with renal disease.

    DOI: 10.1007/s00423-022-02511-x

    Scopus

  • RAD51 Expression as a Biomarker to Predict Efficacy of Preoperative Therapy and Survival for Esophageal Squamous Cell Carcinoma A Large-cohort Observational Study (KSCC1307) Reviewed

    Saeki, H; Jogo, T; Kawazoe, T; Kamori, T; Nakaji, Y; Zaitsu, Y; Fujiwara, M; Baba, Y; Nakamura, T; Iwata, N; Egashira, A; Nakanoko, T; Morita, M; Tanaka, Y; Kimura, Y; Shibata, T; Nakashima, Y; Emi, Y; Makiyama, A; Oki, E; Tokunaga, S; Shimokawa, M; Mori, M

    ANNALS OF SURGERY   275 ( 4 )   692 - 699   2022.4   ISSN:0003-4932 eISSN:1528-1140

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    Language:English   Publisher:Annals of Surgery  

    Objective:The aim of this study is to identify biomarkers that predict efficacy of preoperative therapy and survival for esophageal squamous cell carcinoma (ESCC).Background:It is essential to improve the accuracy of preoperative molecular diagnostics to identify specific patients who will benefit from the treatment; thus, this issue should be resolved with a large-cohort, retrospective observational study.Methods:A total of 656 patients with ESCC who received surgery after preoperative CDDP + 5-FU therapy, docetaxel + CDDP + 5-FU therapy or chemoradiotherapy (CRT) were enrolled. Immunohistochemical analysis of TP53, CDKN1A, RAD51, MutT-homolog 1, and programmed death-ligand 1 was performed with biopsy samples obtained before preoperative therapy, and expression was measured by immunohistochemistry.Results:In all therapy groups, overall survival was statistically separated by pathological effect (grade 3 > grade 2 > grade 0, 1, P < 0.0001). There was no correlation between TP53, CDKN1A, MutT-homolog 1, programmed death-ligand 1 expression, and pathological effect, whereas the proportion of positive RAD51 expression (≥50%) in cases with grade 3 was lower than that with grade 0, 1, and 2 (P = 0.022). In the CRT group, the survival of patients with RAD51-positive tumor was significantly worse than RAD51-negative expressors (P = 0.0119). Subgroup analysis of overall survival with respect to positive RAD51 expression indicated preoperative chemotherapy (CDDP + 5-FU or docetaxel + CDDP + 5-FU) was superior to CRT.Conclusions:In ESCC, positive RAD51 expression was identified as a useful biomarker to predict resistance to preoperative therapy and poor prognosis in patients who received preoperative CRT. Administration of preoperative chemotherapy may be warranted for patients with positive RAD51 expression.

    DOI: 10.1097/SLA.0000000000003975

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Presentations

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MISC

Professional Memberships

  • 日本外科学会

  • 日本消化器外科学会

  • 日本癌治療学会

  • 日本胃癌学会

  • 日本胸部外科学会

  • 日本食道学会

  • 日本内視鏡外科学会

  • 日本癌学会

  • 日本大腸肛門病学会

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Research Projects

  • Elucidation of Inflammation-Related Signaling Involving Stromal Cells in Esophageal Cancer and Development of Novel Therapeutic Strategies

    Grant number:25K19737  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    川副 徹郎

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    Grant type:Scientific research funding

    LIF (Leukemia inhibitory factor)はIL-6ファミリーサイトカインの一つであり、胚細胞、成体細胞で細胞の分化・増殖を調節することが知られている。我々はこれまで、食道扁平上皮癌においてLIFのノックダウンにより食道扁平上皮癌進展が抑制されることを報告した。
    本研究ではLIFやIL-6を標的とした治療を開発し、食道扁平上皮癌の予後改善に取り組むことを目的とする。食堂扁平上皮癌において、LIFが周囲の間質にどのような影響を及ぼすかは明らかではない。これらのクロストークを明らかにすることで、LIFを標的とした治療を臨床応用できると考える。

    CiNii Research

  • Development of an innovative cancer diagnostic system utilizing mass spectrometry imaging.

    Grant number:25K11867  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    財津 瑛子, 安藤 幸滋, 川副 徹郎, 沖 英次, 吉住 朋晴, 工藤 健介

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    Grant type:Scientific research funding

    本研究は質量分析イメージングを応用したがんの迅速診断の手法を開発することが目的である。研究は2つのプロセスからなっている。一つ目は実際のがん組織を用いた検証である。すでに癌の診断がついている組織に対し、実際の迅速診断と同じ環境下で検証し、所要時間、誤判定の頻度、転写基板の特性が実際に迅速診断の環境下で汎用性をもって使用できるかを検討する。次に新規検体で同様の検討を行い再現性の確認を行う。
    二つ目のプロセスは検出されたがん由来分子について解析することである。複数のがん由来分子が検出されることを想定しており、高次元解析等を行うことで臨床応用ができる特異度の高い指標がないかを検証する。

    CiNii Research

  • 食道扁平上皮癌における炎症関連シグナル活性化の分子機序とその制御

    Grant number:2 2 K 1 6 5 2 6  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

    川副 徹郎

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    Authorship:Principal investigator  Grant type:Scientific research funding

    LIF (Leukemia inhibitory factor)はIL-6ファミリーサイトカインの一つであり、胚細胞、成体細胞で細胞の分化・増殖を調節することが知られている。我々はこれまで、食道扁平上皮癌においてLIFがその下流のシグナルであるSFK-YAP経路、JAK-STAT3経路を介して癌進展に寄与すること、またLIFのノックダウンにより食道扁平上皮癌進展が抑制されることを報告した。
    本研究ではLIFやIL-6を標的とした治療を開発し、食道扁平上皮癌の予後改善に取り組むことを目的とする。

    CiNii Research

  • 食道扁平上皮癌における炎症関連シグナル伝達を標的とした新規治療法の開発

    2022 - 2023

    第 5 6 回 がん研究助成金

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    Grant type:Contract research

  • 食道扁平上皮癌における慢性炎症シグナルを標的とした新規治療法の開発

    Grant number:19J11357  2019 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for JSPS Fellows

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 食道扁平上皮癌における慢性炎症シグナルを標的とした新規治療法の開発

    2019 - 2020

    Japan Society for the Promotion of Science  Research Fellowships for Young Scientists

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    Grant type:Joint research

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Class subject

  • 医工学

    2024.4 - 2024.9   First semester

  • 消化管・腹膜

    2024.4 - 2024.9   First semester

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Gastrointestinal Surgery

Clinician qualification

  • Specialist

    Japan Surgical Society(JSS)

  • Specialist

    The Japanese Society of Gastroenterological Surgery

Year of medical license acquisition

  • 2014