Updated on 2025/07/05

Information

 

写真a

 
KONO JUN
 
Organization
Kyushu University Hospital Emergency & Critical Care Center Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425573
External link

Research Areas

  • Life Science / Emergency medicine

  • Life Science / General surgery and pediatric surgery

Degree

  • 医学博士(九州大学)

  • none

Research History

  • Kyushu University Kyushu University Hospital Emergency & Critical Care Center  Assistant Professor 

    2022.4 - Present

  • Kyushu University 救命救急センター Assistant Professor 

Education

  • Kyushu University    

Research Interests・Research Keywords

  • Research theme: clinical research of congenital diaphragmatic hernia, Electrophysiology of intestinal peristalsis

    Keyword: congenital diaphragmatic hernia, electrophysiology

    Research period: 2018.4 - 2023.3

Papers

  • 特集 再手術の戦略と実際 囊胞性肺疾患

    永田 公二, 近藤 琢也, 福田 篤久, 河野 淳, 谷口 直之, 川久保 尚徳, 松浦 俊治, 田尻 達郎

    小児外科   56 ( 7 )   661 - 665   2024.7   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000000873

    CiNii Research

  • The Volume of Intestinal Decompression can Predict the Necessity of Surgical Intervention for Adhesive Small Bowel Obstruction

    Kono, J; Yoshimaru, K; Kondo, T; Takahashi, Y; Toriigahara, Y; Fukuta, A; Obata, S; Kawakubo, N; Nagata, K; Matsuura, T; Tajiri, T

    JOURNAL OF PEDIATRIC SURGERY   58 ( 7 )   1252 - 1257   2023.7   ISSN:0022-3468 eISSN:1531-5037

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    Language:English   Publisher:Journal of Pediatric Surgery  

    Background: There is no standard timing for switching to surgical management for children with adhesive small bowel obstruction (ASBO) who initially receive conservative treatment. We hypothesized that an increased gastrointestinal drainage volume may indicate the need for surgical intervention. Methods: The study population included 150 episodes in the patients less than 20 years of age who received treatment for ASBO in our department from January 2008 to August 2019. Patients were divided into two groups: the successful conservative treatment group (CT) and the eventual surgical treatment group (ST). Following the analysis of all episodes (Study 1), we limited our analysis to only first ASBO episodes (Study 2). We retrospectively reviewed their medical records. Results: There were statistically significant differences in the volume on the 2nd day in both Study 1 (9.1 ml/kg vs. 18.7 ml/kg; p < 0.01) and study 2 (8.1 ml/kg vs. 19.7 ml/kg; p < 0.01). The cut-off value was the same for both Study 1 and Study 2 (11.7 ml/kg). Conclusions: The gastrointestinal drainage volume on the 2nd day in ST was significantly larger than that in CT. Accordingly, we considered that the drainage volume may predict eventual surgical intervention for children with ASBO who initially receive conservative treatment. Level of evidence: Level IV.

    DOI: 10.1016/j.jpedsurg.2023.01.052

    Web of Science

    Scopus

    PubMed

  • COVID19 detection in appendix of acute appendicitis in a child: a case report and review of literature

    Kono, J; Yoshimaru, K; Matsuura, T; Tamaki, A; Takemoto, J; Matsumoto, S; Hotta, T; Kohashi, K; Oda, Y; Tajiri, T

    SURGICAL CASE REPORTS   9 ( 1 )   37   2023.3   ISSN:2198-7793

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  • 急性虫垂炎の小児患者の虫垂におけるCOVID-19の検出 症例報告と文献レビュー(COVID19 detection in appendix of acute appendicitis in a child: a case report and review of literature)

    Kono Jun, Yoshimaru Koichiro, Matsuura Toshiharu, Tamaki Akihiko, Takemoto Junkichi, Matsumoto Shinya, Hotta Taeko, Kohashi Kenichi, Oda Yoshinao, Tajiri Tatsuro

    Surgical Case Reports   9   1 of 7 - 7 of 7   2023.3

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    Language:English   Publisher:(一社)日本外科学会  

    症例は7歳男児。父親に新型コロナウイルス感染症(SARS-CoV-2)の既往があった。2日前からの下腹部痛のため救急医療部へ搬送された。搬送時の体温は39.1度で、血圧は102/61mmHg、心拍数は101bpmであった。受診時に腹部膨満を認め、下腹部にびまん性の圧痛を認めた。臨床検査で白血球数は9900/μL、C反応性蛋白は12.3mg/dLであった。造影CTで腫大した虫垂を認めた。虫垂根部に異常はなく、虫垂内部に糞石と穿孔を認めた。穿孔性虫垂炎と診断し、腹腔鏡下虫垂切除術を施行した。サージカルマスク、N95マスク、フェイスシールド等の個人防護具を装着し、緊急手術を施行した。手術時間は93分であった。術後の培養検査で大腸菌、Streptococcus constellatus、Bacteroides fragilisが検出された。抗菌剤をタゾバクタム/ピペラシリンからメロペネムとメトロニダゾールに変更した。切除標本を用いたリアルタイムPCR法でSARS-CoV-2に陽性を認めた。術後経過は良好で、呼吸器症状もなく、17日後に退院となった。

  • 特集 巨大臍帯ヘルニア治療update 臍帯ヘルニア治療の最近の問題点と長期経過 長期フォロー

    永田 公二, 福田 篤久, 近藤 琢也, 河野 淳, 鳥井ケ原 幸博, 白井 剛, 川久保 尚徳, 吉丸 耕一朗, 松浦 俊治, 田尻 達郎

    小児外科   54 ( 12 )   1237 - 1243   2022.12   ISSN:03856313

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    Publisher:東京医学社  

    DOI: 10.24479/ps.0000000319

    CiNii Research

  • "A salvage technique using a fibrous sheath to avoid the loss of the central veins in cases of pediatric intestinal failure"

    Kondo, T; Nagata, K; Jimbo, T; Kono, J; Kawakubo, N; Obata, S; Yoshimaru, K; Miyoshi, K; Esumi, G; Matsuura, T; Masumoto, K; Tajiri, T; Taguchi, T

    PEDIATRIC SURGERY INTERNATIONAL   38 ( 12 )   1855 - 1860   2022.12   ISSN:0179-0358 eISSN:1437-9813

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    Language:English   Publisher:Pediatric Surgery International  

    Purpose: The number of accessible central veins (CVs) affects the prognosis of patients with intestinal failure (IF). The loss of residual CVs should be avoided. We, therefore, evaluated the efficacy of a new CV catheter-exchange technique using a subcutaneous fibrous sheath (FS) in pediatric IF patients. Methods: We retrospectively collected the CV catheter (CVC) data of pediatric IF patients managed from January 2009 to December 2019. The data were divided into two groups; Groups 1 (CVCs placed with the FS method) and Group 2 (CVCs placed by the primary or another insertion). The main outcome was the CVC indwelling time. Results: Eighty-five CVCs were analyzed. The FS method was attempted in 47 cases and succeeded in 40 (85%). No significant difference was observed between the groups regarding characteristics. A log-rank test revealed an equivalent CVC indwelling time between the two groups (Group 1: 268 [126–588] days vs. Group 2: 229 [126–387] days, p = 0.256). Conclusions: The FS method is highly recommended for pediatric IF patients, as its attempt showed a high success rate with an indwelling time equivalent to primary insertion. The FS method leads to the prolonged use of a single CV and thereby contributes to improving the outcomes of pediatric IF patients.

    DOI: 10.1007/s00383-022-05233-9

    Web of Science

    Scopus

    PubMed

  • The efficacy of the postnatal nasogastric tube position as a prognostic marker of left-sided isolated congenital diaphragmatic hernia

    Kono, J; Nagata, K; Terui, K; Amari, S; Toyoshima, K; Inamura, N; Koike, Y; Yamoto, M; Okazaki, T; Yazaki, Y; Okuyama, H; Hayakawa, M; Furukawa, T; Masumoto, K; Yokoi, A; Usui, N; Tajiri, T

    PEDIATRIC SURGERY INTERNATIONAL   38 ( 12 )   1873 - 1880   2022.12   ISSN:0179-0358 eISSN:1437-9813

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    Language:English   Publisher:Pediatric Surgery International  

    Purpose: The prenatal diagnosis of the stomach position in congenital diaphragmatic hernia (CDH) has been a reliable prognostic factor, but few studies have focused on the postnatal position. We therefore evaluated the significance of the nasogastric (NG) tube position just after birth. Methods: The Japanese CDH Study Group database enrolled 1037 CDH neonates over 15 years. In our multicenter retrospective study, 464 cases of left-sided isolated CDH with prenatal diagnoses were divided into two groups: NG tube below the diaphragm (BD; n = 190) or above the diaphragm (AD; n = 274). The primary outcome was the 90-day survival rate, and the secondary outcomes were mechanical ventilation duration, hospitalization duration, and recurrence rate. Results: The BD group had a significantly higher 90-day survival rate (98.4 vs. 89.4%, p < 0.001), shorter mechanical ventilation (11 vs. 19 days, p < 0.001), shorter hospitalization (38 vs. 59 days, p < 0.001), and lower recurrence rate (p = 0.002) than the AD group. A multivariate analysis showed that BD (adjusted odds ratio, 3.68; 95% confidence interval 1.02–13.30) was a favorable prognostic factor for the 90-day survival. Conclusion: The assessment of the NG tube position revealed it to be a reliable prognostic factor of left-sided isolated CDH. Therefore, it should be included as a routine assessment.

    DOI: 10.1007/s00383-022-05226-8

    Web of Science

    Scopus

    PubMed

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Presentations

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MISC

Research Projects

  • 大型自己細胞パッチによる新規先天性横隔膜ヘルニア根治術の開発

    Grant number:22K12784  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    張 秀英, 永田 公二, 田尻 達郎, 河野 淳

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    Grant type:Scientific research funding

    先天性横隔膜ヘルニア(CDH)は、先天的な横隔膜筋 肉の欠損に伴う腹部臓器の胸腔内への嵌入により肺低形成が出現する死亡率25%と予後不良 な疾患である。本疾患の問題点として、欠損孔が大きい症例に対しては人工布を用いて欠損孔閉鎖を行うが、人工布は収縮力がないことや体の成長に応じて大きくならないため、術後再発、胸郭変形などがある。これを解決するために、申請者らはヒトの皮膚線維芽細胞と血管内皮細胞を混合して細胞パッチをバイオ3Dプリンターで作製し、世界で初めて細胞だけで作製したパッチで横隔膜の修復に成功した。そこで本研究では臨床応用に向けてのパッチの大型化と中動物での有効性を実証する研究を行う。

    CiNii Research

  • 新規評価システム搭載型高度手術シミュレーター開発と効果検証に関する研究

    Grant number:22K12845  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    小幡 聡, 田尻 達郎, 永田 公二, 福田 篤久, 近藤 琢也, 河野 淳

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    Grant type:Scientific research funding

    本研究は、小児のみならず成人でも安全かつ確実な内視鏡外科手術を提供することを最終目標とし、advanced surgeryに対する内視鏡外科手術の技術習得のみならず客観的技術評価が可能で、かつ繰り返し利用可能な手術トレーニングシミュレーターを開発し、外科医の技術向上とともに患者の安全性を担保することを本研究目的とする。

    CiNii Research

  • 乳歯歯髄幹細胞によるヒルシュスプルング病と類縁疾患の病因解明および根治療法の開発

    Grant number:23K21447  2021.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    田口 智章, 田尻 達郎, 松浦 俊治, 梶岡 俊一, 山座 孝義, 山座 治義, 孝橋 賢一, 樗木 晶子, 吉丸 耕一朗, 松尾 忠行, 中園 栄里, 河野 淳, 桐野 浩輔

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    Grant type:Scientific research funding

    継続課題のため、記入しない。

    CiNii Research

  • ヒルシュスプルング病類縁疾患の新規治療法を目指した遺伝子変異の同定とその機能解析

    Grant number:19K09098 

    河野 淳, 桐野 浩輔, 田口 智章, 吉丸 耕一朗

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    Grant type:Scientific research funding

    腸管神経節細胞僅少症や巨大膀胱短小結腸腸管蠕動不全症、慢性特発性偽性腸閉塞症は著しい腸管蠕動不全を認め、腸からの栄養吸収が困難で機能的腸閉塞に伴う重症腸炎を繰り返す。そのため姑息的手術を繰り返し、経静脈栄養に依存し、その合併症は時に致命的である。しかしこれらの疾患の病因は未だ不明であり、複数の遺伝子変異が報告されているにも関わらず、遺伝子変異による発症のメカニズムは解明されていない。本研究では新規創薬や生体外ゲノム編集によるH類縁の新たな治療法をめざし、遺伝子導入を行った細胞により変異遺伝子の機能解析を行い、H類縁のメカニズムを解明する。これは既存の報告よりも踏み込んだ世界初の試みである。

    CiNii Research

Educational Activities

  • 救命センターにおけるベッドサイド、クリニカルクラークシップの学生への指導