NISHIHARA MASAAKI
Organization
Kyushu University Hospital Emergency & Critical Care Center Assistant Professor
School of Medicine Department of Medicine（Joint Appointment）
Title
Assistant Professor
Contact information
Profile
救命救急センター及び集中治療室において重症患者の初期治療、全身管理に従事している。
重症循環不全患者に対する体外循環に関しての臨床研究にも携わる。
令和5年度からは基礎研究【慢性腎臓病を併存する敗血症における高酸素血症が中枢性交感神経系と予後へ与える影響】にも携わる。
Degree
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Oxidative stress in the rostral ventrolateral medulla modulates excitatory and inhibitory inputs in spontaneously hypertensive rats
Research History
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2014年4月～2016年3月独立行政法人国立病院機構九州医療センター循環器内科スタッフ
2014年4月～2016年3月独立行政法人国立病院機構九州医療センター循環器内科スタッフ
Research Interests・Research Keywords
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Research theme：Impact of hyperoxemia on the central sympathetic nervous system and prognosis in sepsis with comorbid chronic kidney disease.
Keyword：sepsis, chronic kidney disease, hyperoxia, sympathetic nervous system
Research period： 2023.4
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Research theme：Investigation of new onset AF/AFL in critically ill patients in Japan
Keyword：New onset AF/AFL
Research period： 2021.4 - 2023.3
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Research theme：Therapeutic intervention via central sympathetic nerve activity for sepsis complicated by chronic kidney disease
Keyword：sepsis, chronic kidney disease, sympathetic nerve activity
Research period： 2020.4 - 2023.3
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Research theme：Hyperoxemia and neurological outcomes in patients with out-of-hospital cardiac arrest rescued by extracorporeal cardiopulmonary resuscitation: Insight from the nationwide multicenter observational JAAM-OHCA (Japan Association for Acute Medicine) registry
Keyword：Hyperoxemia, ECPR, neurological outcome
Research period： 2019.11 - 2023.3
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Research theme：Predictive factors for long-term neurological outcomes in cardiac arrest patients resuscitated by extracorporeal cardiopulmonary resuscitation
Keyword：out-of-hospital cardiac arrest, in-hospital cardiac arrest, extracorporeal cardiopulmonary resuscitation, long-term neurological outcome, prognostication
Research period： 2019.4
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Research theme：Bleeding events associated factors in adult patients undergoing extracorporeal membrane oxygenation
Keyword：extracorporeal membrane oxygenation, bleeding events
Research period： 2017.10 - 2018.3
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Research theme：The effect of renal denervation on central mechanism of hypertension in hypertensive mice with chronic kidney disease
Keyword：hypertension, chronic kidney disease, renal denervation, sympathetic nerve activity
Research period： 2017.3 - 2019.3
Papers
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Emphysematous pyelonephritis with ST elevation accompanied by reciprocal changes mimicking acute coronary syndrome. Reviewed International journal
Hatakeyama K, Shono Y, Hashimoto T, Sakamoto T, Nishihara M, Iyonaga T, Mizuguchi S, Sakamoto T, Maki J, Akahoshi T.
2023.8
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Contribution of afferent renal nerve signals to acute and chronic blood pressure regulation in stroke-prone spontaneously hypertensive rats Reviewed International journal
Ikeda S, Shinohara K, Kashihara S, Matsumoto S, Yoshida D, Nakashima R, Ono Y, Nishihara M, Katsurada K, Tsutsui H
Hypertension Research 2023.1
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Impact of Antithrombin Activity Levels Following Recombinant Antithrombin Gamma Therapy in Patients with Sepsis-Induced Disseminated Intravascular Coagulation Reviewed International journal
Tomohiko Akahoshi, Noriyuki Kaku, Yuji Shono, Yuzo Yamamoto, Keita Takahashi, Takeshi Iyonaga, Kenta Momii, Masaaki Nishihara, Jun Maki, Kentaro Tokuda, Ken Yamaura
Clinical and Applied Thrombosis/Hemostasis 2022.11
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Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit Reviewed International journal
Yuji Shono, Satomi Mezuki, Tomohiko Akahoshi, Masaaki Nishihara, Noriyuki Kaku, Jun Maki, Kentaro Tokuda, Takanari Kitazono
The Journal of International Medical Research 2022.9
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Hyperoxemia is Associated With Poor Neurological Outcomes in Patients With Out-of-Hospital Cardiac Arrest Rescued by Extracorporeal Cardiopulmonary Resuscitation: Insight From the Nationwide Multicenter Observational JAAM-OHCA (Japan Association for Acute Medicine) Registry. Reviewed International journal
Masaaki Nishihara, Ken-Ichi Hiasa, Nobuyuki Enzan, Kenzo Ichimura, Takeshi Iyonaga, Yuji Shono, Masahiro Kashiura, Takashi Moriya, Takanari Kitazono, Hiroyuki Tsutsui
The Journal of Emergency Medicine 2022.8
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Delayed administration of epinephrine is associated with worse neurological outcomes in patients with out-of-hospital cardiac arrest and initial pulseless electrical activity: insight from the nationwide multicentre observational JAAM-OHCA (Japan Association for Acute Medicine) registry Reviewed International journal
Nobuyuki Enzan, Ken Ichi Hiasa, Kenzo Ichimura, Masaaki Nishihara, Takeshi Iyonaga, Yuji Shono, Takeshi Tohyama, Kouta Funakoshi, Takanari Kitazono, Hiroyuki Tsutsui
European Heart Journal - Acute Cardiovascular Care 2022.6
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Association between short-term neurological outcomes and extreme hyperoxia in patients with out-of-hospital cardiac arrest who underwent extracorporeal cardiopulmonary resuscitation: a retrospective observational study from a multicenter registry Reviewed International journal
BMC Cardiovascular Disorders 2022.4
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Feasibility and efficacy of an ultra-short side branch-dedicated balloon in coronary bifurcation stenting Reviewed International journal
Yoshinobu Murasato, Masaaki Nishihara, Takahiro Mori, Kyohei Meno, Kodai Shibao, Katsuhiko Takenaka, Kiyotaka Iwasaki
EuroIntervention 2021.8
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Efficacy of thromboelastography in the management of anticoagulation for veno-venous extracorporeal membrane oxygenation in a coronavirus disease 2019 patient: A case report Reviewed International journal
Ryosuke Nakashima, Masaaki Nishihara, Takeshi Iyonaga, Sho Iwasaka Yuzo Yamamoto, Yuji Shono, Jun Maki, Kentaro Tokuda, Tomohiko Akahoshi, Taiki Higo, Takanari Kitazono, Hiroyuki Tsutsui
Medicine 2021.6
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Masaaki Nishihara, Ko Takesue, Yoshitaka Hirooka
Clinical and Experimental Hypertension 41 ( 3 ) 211 - 219 2019.4
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Masaaki Nishihara, Ko Takesue, Yoshitaka Hirooka
Autonomic Neuroscience: Basic and Clinical 204 88 - 97 2017.5
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The mechanism of blood pressure regulation by the central nervous system Reviewed
Masaaki Nishihara, Yoshitaka Hirooka
Nippon rinsho. Japanese journal of clinical medicine 73 ( 11 ) 1798 - 1800 2015.11
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Masaaki Nishihara, Yoshitaka Hirooka, Kenji Sunagawa
Clinical and Experimental Hypertension 37 ( 1 ) 33 - 38 2015.2
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[Effect of sympathetic nervous system on circadian rhythm of blood pressure]. Reviewed
Masaaki Nishihara, Yoshitaka Hirooka
Nippon rinsho. Japanese journal of clinical medicine 72 ( 8 ) 1374 - 1378 2014
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Masaaki Nishihara, Yoshitaka Hirooka, Takuya Kishi, Kenji Sunagawa
Journal of hypertension 30 ( 9 ) 1758 - 1765 2012.9
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Masaaki Nishihara, Yoshitaka Hirooka, Ryuichi Matsukawa, Takuya Kishi, Kenji Sunagawa
Journal of hypertension 30 ( 1 ) 97 - 106 2012.1
Research Projects
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慢性腎臓病を併存する敗血症における高酸素血症が中枢性交感神経系と予後へ与える影響
Grant number：23K08478 2023 - 2025
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
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慢性腎臓病を合併した敗血症に対する中枢性交感神経系を介した治療介入の検討
Grant number：20K09288 2020 - 2022
日本学術振興会 科学研究費助成事業 基盤研究(C)
Authorship：Principal investigator Grant type：Scientific research funding
Other educational activity and Special note
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2018 Special Affairs
Outline of Social Contribution and International Cooperation activities
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日本循環制御医学会の評議員として活動
Activities contributing to policy formation, academic promotion, etc.
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2017.4 - 2019.3 日本循環制御学会
日本循環制御学会の評議員に着任。年に数回の評議委員会へ出席して、国内の当各分野の発展に寄与すべく活発な討議を行う。
Specialized clinical area
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Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Cardiology
Clinician qualification
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Specialist
日本集中治療医学会
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Specialist
The Japanese Circulation Society（JCS）
Year of medical license acquisition
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2005
Notable Clinical Activities
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2016年度より救急及び集中治療医療に従事する。 成人心停止例への体外式膜型人工肺を用いた心肺蘇生法に関する研究に携わる。