2024/11/27 更新

お知らせ

 

写真a

メズキ サトミ
賣豆紀 智美
MEZUKI SATOMI
所属
九州大学病院 救命救急センター 助教
職名
助教

研究テーマ・研究キーワード

  • 研究テーマ: 周術期および重症患者に対して経頭蓋超音波ドップラーを用いた脳循環モニタリングの有用性を検討する

    研究キーワード: 経頭蓋超音波ドップラー、脳循環モニタリング、神経集中治療

    研究期間: 2024年4月

論文

  • Effect of smoking status on clinical outcomes after reperfusion therapy for acute ischemic stroke

    Irie, F; Matsuo, R; Mezuki, S; Wakisaka, Y; Kamouchi, M; Kitazono, T; Ago, T; Ishitsuka, T; Ibayashi, S; Kusuda, K; Fujii, K; Nagao, T; Okada, Y; Yasaka, M; Ooboshi, H; Kitazono, T; Irie, K; Omae, T; Toyoda, K; Nakane, H; Kamouchi, M; Sugimori, H; Arakawa, S; Fukuda, K; Ago, T; Kitayama, J; Fujimoto, S; Arihiro, S; Kuroda, J; Wakisaka, Y; Fukushima, Y; Matsuo, R; Irie, F; Nakamura, K; Kiyohara, T

    SCIENTIFIC REPORTS   14 ( 1 )   9290   2024年4月   ISSN:2045-2322

     詳細を見る

    記述言語:英語   出版者・発行元:Scientific Reports  

    Smoking has detrimental effects on the cardiovascular system; however, some studies have reported better clinical outcomes after thrombolysis for ischemic stroke in smokers than in nonsmokers, a phenomenon known as the smoking paradox. Therefore, this study aimed to examine the smoking paradox in patients with ischemic stroke receiving reperfusion therapy. Data were collected from a multicenter hospital-based acute stroke registry in Fukuoka, Japan. The 1148 study patients were categorized into current and noncurrent smokers. The association between smoking and clinical outcomes, including neurological improvement (≥ 4-point decrease in the National Institutes of Health Stroke Scale during hospitalization or 0 points at discharge) and good functional outcomes (modified Rankin Scale score of 0–2) at 3 months, was evaluated using logistic regression analysis and propensity score-matched analysis. Among the participants, 231 (20.1%) were current smokers. The odds ratios (ORs) of favorable outcomes after adjusting for potential confounders were not significantly increased in current smokers (OR 0.85, 95% confidence interval [CI] 0.60–1.22 for neurological improvement; OR 0.95, 95% CI 0.65–1.38 for good functional outcome). No significant association was found in the propensity score-matched cohorts. Smoking cessation is strongly recommended since current smoking was not associated with better outcomes after reperfusion therapy.

    DOI: 10.1038/s41598-024-59508-3

    Web of Science

    Scopus

    PubMed

  • Body temperature in the acute phase and clinical outcomes after acute ischemic stroke

    Mezuki, S; Matsuo, R; Irie, F; Shono, Y; Kuwashiro, T; Sugimori, H; Wakisaka, Y; Ago, T; Kamouchi, M; Kitazono, T

    PLOS ONE   19 ( 1 )   e0296639   2024年1月   ISSN:1932-6203

     詳細を見る

    記述言語:英語   出版者・発行元:PLoS ONE  

    Background This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months. Methods We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1–36.5◦C, Q2: 36.5–36.7◦C, Q3: 36.7–36.8◦C, Q4: 36.8–37.1◦C, and Q5: 37.1–39.1◦C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3–6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes. Results The patient’s mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65–0.99] vs. Q1) to Q5 (0.33 [0.28–0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03–1.79]) to Q5 (6.44 [5.19–8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1–3 and with longer duration with body temperature >37.0◦C. Conclusions Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.

    DOI: 10.1371/journal.pone.0296639

    Web of Science

    Scopus

    PubMed

  • Prediction of intracranial lesions in patients with consciousness disturbance by ultrasonography in the intensive care unit

    Shono, Y; Mezuki, S; Akahoshi, T; Nishihara, M; Kaku, N; Maki, J; Tokuda, K; Kitazono, T

    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH   50 ( 9 )   3000605221119358   2022年9月   ISSN:0300-0605 eISSN:1473-2300

     詳細を見る

    記述言語:英語   出版者・発行元:Journal of International Medical Research  

    Objective: This study was performed to evaluate the correlation between parameters measured by bedside ultrasonography and detection of intracranial organic lesions in patients with impaired consciousness in an intensive care unit (ICU) setting. Methods: We retrospectively reviewed the medical records of patients who were admitted to our ICU from April 2017 to July 2019. Patients who underwent computed tomography or magnetic resonance imaging examination and measurement of the flow velocity of the carotid and intracranial arteries and the optic nerve sheath diameter by ultrasonography were selected for analysis. Results: In total, 64 patients were analyzed in this study. Of these, intracranial lesions were detected by computed tomography or magnetic resonance imaging in 17 (27%) patients. The left:right ratio of the end-diastolic velocity of the bilateral common carotid artery (CCA-ED ratio) and the pulsatility index of the middle cerebral artery (MCA-PI) were significantly higher in patients with than in those without intracranial lesions. The cut-off value of the CCA-ED ratio was 1.55 (sensitivity, 66.7%; specificity, 81.6%), and that of the MCA-PI was 1.21 (sensitivity, 57.1%; specificity, 76.7%). Conclusion: Bedside ultrasonography is useful for predicting intracranial lesions requiring therapeutic intervention in ICU patients with impaired consciousness.

    DOI: 10.1177/03000605221119358

    Web of Science

    Scopus

    PubMed

講演・口頭発表等

所属学協会

  • 日本集中治療医学会

  • 日本脳卒中学会

  • 日本救急医学会

  • 日本内科学会

教育活動概要

  • 救命救急センター・ICUでの研修医・医員への教育および医学部学生のベッドサイド実習における教育を行う。

専門診療領域

  • 生物系/医歯薬学/内科系臨床医学/脳卒中学

  • 生物系/医歯薬学/外科系臨床医学/救急医学

臨床医資格

  • 専門医

    日本救急医学会

  • 専門医

    日本内科学会

  • 専門医

    日本脳卒中学会

医師免許取得年

  • 2009年

特筆しておきたい臨床活動

  • 神経救急、神経集中治療