2015 ESDR/JSID Young Fellow Collegiality Awards

2015.7   Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption

留学助成金

2012.1   公益財団法人 中冨健康科学振興財団  

留学助成金

2011.10   公益財団法人 持田記念医学薬学振興財団  

第11回皮膚総合研究奨励賞（堀賞）

2011.2   九大皮膚科自遠会  

EADC Award

2010.9   The First Eastern Asia Dermatology Congress  

BD Japan Young Investigators’ Travel Award

2010.8  

第10回皮膚総合研究奨励賞（堀賞）

2010.2   自遠会  

第9回皮膚総合研究奨励賞（堀賞）

2009.2   自遠会  

Best poster presentation

2008.12   International Conference on Environmental Hormones and Health Effects  

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis Reviewed International journal

Tsuji, Gaku; Hashimoto-Hachiya, Akiko; Kiyomatsu-Oda, Mari; Takemura, Masaki; Ohno, Fumitaka; Ito, Takamichi; Morino-Koga, Saori; Mitoma, Chikage; Nakahara, Takeshi; Uchi, Hiroshi; Furue, Masutaka

CELL DEATH & DISEASE   8   2017.7

Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma. Reviewed International journal

Takamichi Ito, Gaku Tsuji, Fumitaka Ohno, Hiroshi Uchi, Takeshi Nakahara, Akiko Hachiya, Yuichi Yoshida, Osamu Yamamoto, Oda, Yoshinao, Masutaka Furue

Am J Pathol   186 ( 4 )   1036 - 1043   2016.4

Histone deacetylase 6 inhibition impairs effector CD8 T-cell functions during skin inflammation. Reviewed International journal

Gaku Tsuji

J Allergy Clin Immunol.   135(5):1228 - 1239   2015.5

Identification of Ketoconazole as an AhR-Nrf2 Activator in Cultured Human Keratinocytes: The Basis of Its Anti-Inflammatory Effect. Reviewed International journal

Tsuji G, Takahara M, Uchi H, Matsuda T, Chiba T, Takeuchi S, Yasukawa F, Moroi Y, Furue M.

J Invest Dermatol.   2011.7

An environmental contaminant, benzo(a)pyrene, induces oxidative stress-mediated interleukin-8 production in human keratinocytes via the aryl hydrocarbon receptor signaling pathway. Reviewed International journal

Tsuji G, Takahara M, Uchi H, Takeuchi S, Mitoma C, Moroi Y, Furue M.

J Dermatol Sci.   ６２ ( １ )   2011.4

表皮嚢腫より生じた有棘細胞癌

辻学, 安川晋輔, 増田禎一, 師井洋一, 占部和敬, 古江増隆

皮膚病診療   ２８ ( ９ )   2006.9

Degos病 (悪性萎縮性丘疹症) Reviewed

辻学, 師井洋一, 占部和敬, 古江増隆

4 ( ９ )   2005.8

Exploring patient background and biomarkers associated with the development of dupilumab-associated conjunctivitis and blepharitis. International journal

Makiko Kido-Nakahara, Daisuke Onozuka, Kenji Izuhara, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Masutaka Furue, Norito Katoh, Takeshi Nakahara

Allergology international : official journal of the Japanese Society of Allergology   73 ( 2 )   332 - 334   2024.4

The Therapeutic Aryl Hydrocarbon Receptor-Modulating Agent Tapinarof Regulates SEMA3A Expression in Human Keratinocytes through NRF2. International journal

144 ( 3 )   710 - 713   2024.3

The ability of biomarkers to assess the severity of atopic dermatitis. International journal

Takeshi Nakahara, Daisuke Onozuka, Satoshi Nunomura, Hidehisa Saeki, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Ryo Saito, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido-Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Ayano Fukushima-Nomura, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue, Kenji Izuhara

The journal of allergy and clinical immunology. Global   3 ( 1 )   100175 - 100175   2024.2

Regulatory Mechanism of the IL-33-IL-37 Axis via Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis. International journal

Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara

International journal of molecular sciences   24 ( 19 )   2023.9

PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte proline-rich protein in human keratinocytes. International journal

Gaku Tsuji, Akiko Hashimoto-Hachiya, Ayako Yumine, Masaki Takemura, Makiko Kido-Nakahara, Takamichi Ito, Kazuhiko Yamamura, Takeshi Nakahara

Journal of dermatological science   110 ( 2 )   61 - 68   2023.5

Novel Therapeutic Targets for the Treatment of Atopic Dermatitis. International journal

Gaku Tsuji, Kazuhiko Yamamura, Koji Kawamura, Makiko Kido-Nakahara, Takamichi Ito, Takeshi Nakahara

Biomedicines   11 ( 5 )   2023.4

Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma. International journal

Yuka Tanaka, Takamichi Ito, Yumiko Kaku-Ito, Keiko Tanegashima, Gaku Tsuji, Makiko Kido-Nakahara, Yoshinao Oda, Takeshi Nakahara

Cell death discovery   9 ( 1 )   54 - 54   2023.2

Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B-PAD study). International journal

Takeshi Nakahara, Kenji Izuhara, Daisuke Onozuka, Hidehisa Saeki, Satoshi Nunomura, Motoi Takenaka, Mai Matsumoto, Yoko Kataoka, Rai Fujimoto, Sakae Kaneko, Eishin Morita, Akio Tanaka, Michihiro Hide, Tatsuro Okano, Tomomitsu Miyagaki, Natsuko Aoki, Kimiko Nakajima, Susumu Ichiyama, Makiko Kido-Nakahara, Kyoko Tonomura, Yukinobu Nakagawa, Risa Tamagawa-Mineoka, Koji Masuda, Takuya Takeichi, Masashi Akiyama, Yozo Ishiuji, Michie Katsuta, Yuki Kinoshita, Chiharu Tateishi, Aya Yamamoto, Akimichi Morita, Haruna Matsuda-Hirose, Yutaka Hatano, Hiroshi Kawasaki, Keiji Tanese, Mamitaro Ohtsuki, Koji Kamiya, Yudai Kabata, Riichiro Abe, Hiroshi Mitsui, Tatsuyoshi Kawamura, Gaku Tsuji, Norito Katoh, Masutaka Furue

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology   53 ( 2 )   233 - 238   2023.2

Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes. International journal

Xianghong Yan, Gaku Tsuji, Akiko Hashimoto-Hachiya, Masutaka Furue

Journal of clinical medicine   11 ( 21 )   2022.10

Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer. International journal

Kukizo Miyamoto, Yoko Munakata, Xianghong Yan, Gaku Tsuji, Masutaka Furue

Journal of clinical medicine   11 ( 8 )   2022.4

Role of ERK Pathway in the Pathogenesis of Atopic Dermatitis and Its Potential as a Therapeutic Target. International journal

Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara

International journal of molecular sciences   23 ( 7 )   2022.3

The Antidiabetic Agent Metformin Inhibits IL-23 Production in Murine Bone-Marrow-Derived Dendritic Cells. International journal

Tomoyo Matsuda-Taniguchi, Masaki Takemura, Takeshi Nakahara, Akiko Hashimoto-Hachiya, Ayako Takai-Yumine, Masutaka Furue, Gaku Tsuji

Journal of clinical medicine   10 ( 23 )   2021.11

Efficacy of Dupilumab for Atopic Dermatitis According to Clinical Course and Clinical Findings: A Multicentre Retrospective Study. International journal

Takeshi Nakahara, Makiko Kido-Nakahara, Daisuke Onozuka, Sawako Sakai, Tomoko Hirose, Nobutoshi Take, Akiko Sugiyama, Kayo Harada, Gaku Tsuji, Satoko Kikuchi, Futoshi Kohda

Acta dermato-venereologica   101 ( 11 )   adv00586   2021.11

Hydroxychloroquine induces matrix metalloproteinase 1 expression and apoptosis in neurofibromatosis type 1 Schwann cells. International journal

Ayako Yumine, Gaku Tsuji

Journal of dermatological science   104 ( 2 )   142 - 145   2021.11

A ubiquitin-like protein encoded by the "noncoding" RNA TINCR promotes keratinocyte proliferation and wound healing. International journal

Akihiro Nita, Akinobu Matsumoto, Ronghao Tang, Chisa Shiraishi, Kazuya Ichihara, Daisuke Saito, Mikita Suyama, Tomoharu Yasuda, Gaku Tsuji, Masutaka Furue, Bumpei Katayama, Toshiyuki Ozawa, Teruasa Murata, Teruki Dainichi, Kenji Kabashima, Atsushi Hatano, Masaki Matsumoto, Keiichi I Nakayama

PLoS genetics   17 ( 8 )   e1009686   2021.8

Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula. International journal

Kukizo Miyamoto, Bandara Dissanayake, Tatsuya Omotezako, Masaki Takemura, Gaku Tsuji, Masutaka Furue

Journal of clinical medicine   10 ( 11 )   2021.6

Metalloproteinase 1 downregulation in neurofibromatosis 1: Therapeutic potential of antimalarial hydroxychloroquine and chloroquine. International journal

Gaku Tsuji, Ayako Takai-Yumine, Takahiro Kato, Masutaka Furue

Cell death & disease   12 ( 6 )   513 - 513   2021.5

Basics and recent advances in the pathophysiology of atopic dermatitis. International journal

Takeshi Nakahara, Makiko Kido-Nakahara, Gaku Tsuji, Masutaka Furue

The Journal of dermatology   48 ( 2 )   130 - 139   2021.2

Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins: A competing risk analysis among Yusho patients. International journal

Daisuke Onozuka, Yuko Nakamura, Gaku Tsuji, Masutaka Furue

Environment international   147   106320 - 106320   2021.2

Aryl Hydrocarbon Receptor and Dioxin-Related Health Hazards-Lessons from Yusho. International journal

Masutaka Furue, Yuji Ishii, Kiyomi Tsukimori, Gaku Tsuji

International journal of molecular sciences   22 ( 2 )   2021.1

Guidelines for the management of dermatomycosis (2019). International journal

Takashi Mochizuki, Ryoji Tsuboi, Ken Iozumi, Sumiko Ishizaki, Tsuyoshi Ushigami, Yumi Ogawa, Takehiko Kaneko, Masaaki Kawai, Yuki Kitami, Masahiro Kusuhara, Takeshi Kono, Toshiki Sato, Tomotaka Sato, Harunari Shimoyama, Motoi Takenaka, Hiroshi Tanabe, Gaku Tsuji, Yuichiro Tsunemi, Yasuki Hata, Kazutoshi Harada, Tomoo Fukuda, Tetsuo Matsuda, Ryuji Maruyama

The Journal of dermatology   47 ( 12 )   1343 - 1373   2020.12

IL-24 Negatively Regulates Keratinocyte Differentiation Induced by Tapinarof, an Aryl Hydrocarbon Receptor Modulator: Implication in the Treatment of Atopic Dermatitis. International journal

Yen Hai Vu, Akiko Hashimoto-Hachiya, Masaki Takemura, Ayako Yumine, Yasutaka Mitamura, Takeshi Nakahara, Masutaka Furue, Gaku Tsuji

International journal of molecular sciences   21 ( 24 )   2020.12

Mortality in Yusho patients exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: a 50-year retrospective cohort study. International journal

Daisuke Onozuka, Yuko Nakamura, Gaku Tsuji, Masutaka Furue

Environmental health : a global access science source   19 ( 1 )   119 - 119   2020.11

IL-4 Augments IL-31/IL-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic Cells: Implications for Atopic Dermatitis Invited Reviewed International journal

Miake, Sho; Tsuji, Gaku; Takemura, Masaki; Hashimoto-Hachiya, Akiko; Vu, Yen Hai; Furue, Masutaka; Nakahara, Takeshi

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   20 ( 16 )   2019.8

Upregulation of FLG, LOR, and IVL Expression by Rhodiola crenulata Root Extract via Aryl Hydrocarbon Receptor: Differential Involvement of OVOL1. Invited Reviewed International journal

Hashimoto-Hachiya A, Tsuji G, Murai M, Yan X, Furue M.

Int J Mol Sci.   2018.6

The pruritogenic mediator endothelin-1 shifts the dendritic cell-T-cell response toward Th17/Th1 polarization Invited Reviewed International journal

Nakahara, T.; Kido-Nakahara, M.; Ohno, F.; Ulzii, D.; Chiba, T.; Tsuji, G.; Furue, M.

ALLERGY   73 ( 2 )   511 - 515   2018.2

Evaluation of mapping biopsies for extramammary Paget disease A retrospective study Reviewed International journal

Yumiko Kaku-Ito, Takamichi Ito, Gaku Tsuji, Takeshi Nakahara, Akihito Hagihara, Masutaka Furue, Uchi Hiroshi

Journal of the American Academy of Dermatology   2018.1

An endogenous tryptophan photo-product, FICZ, is potentially involved in photo-aging by reducing TGF-beta-regulated collagen homeostasis Invited Reviewed International journal

Murai, Mika; Tsuji, Gaku; Hashimoto-Hachiya, Akiko; Kawakami, Yoshihito; Furue, Masutaka; Mitoma, Chikage

JOURNAL OF DERMATOLOGICAL SCIENCE   89 ( 1 )   19 - 26   2018.1

Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway Invited Reviewed International journal

Hirano, Akiko; Goto, Masashi; Mitsui, Tsukasa; Hashimoto-Hachiya, Akiko; Tsuji, Gaku; Furue, Masutaka

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   18 ( 9 )   2017.9

Acral lentiginous melanoma versus other melanoma: A single-center analysis in Japan Invited Reviewed International journal

Wada, Maiko; Ito, Takamichi; Tsuji, Gaku; Nakahara, Takeshi; Hagihara, Akihito; Furue, Masutaka; Uchi, Hiroshi

JOURNAL OF DERMATOLOGY   44 ( 8 )   932 - 938   2017.8

Potential role of the OVOL1-OVOL2 axis and c-Myc in the progression of cutaneous squamous cell carcinoma Invited Reviewed International journal

Ito, Takamichi; Tsuji, Gaku; Ohno, Fumitaka; Nakahara, Takeshi; Uchi, Hiroshi; Furue, Masutaka

MODERN PATHOLOGY   30 ( 7 )   919 - 927   2017.7

Simultaneous onset of sporotrichosis in mother and daughter. Invited Reviewed International journal

Gaku Tsuji

J Dermatol.   2016.10

Cutaneous Pseudallescheria boydii/Scedosporium apiospermum complex infection in immunocompromised patients: A report of two cases. Invited Reviewed International journal

Gaku Tsuji

J Dermatol.   2016.9

Mucous membrane pemphigoid with antibodies to the beta(3) subunit of Laminin 332 in a patient with acute myeloblastic leukemia and graft-versus-host disease. Reviewed International journal

Takahara M, Tsuji G, Ishii N, Dainichi T, Hashimoto T, Kohno K, Kamezaki K, Nagafuji K, Takeuchi S, Moroi Y, Furue M.

Dermatology   219 ( ４ )   2009.10

Activation of aryl hydrocarbon receptor-nuclear factor erythroid 2-related factor 2 signaling axis by epidermal growth factor receptor inhibitors: a possible mechanism for acneiform eruption. Invited International conference

Gaku Tsuji

45th Annual ESDR Meeting  2015.9 

RAPID DETECTION OF SPOROTHRIX SCHENCKII BY USING A LOOP-MEDIATED ISOTHERMAL AMPLIFICATION (LAMP) ASSAY International conference

Gaku TSUJI, Masakazu TAKAHARA, Tetsuo MATSUDA, Kenjiro TAKEI, Yoichi MOROI, Masutaka FURUE

22nd World Congress of Dermatology 2011  2011.5 

Ketoconazole activates nuclear factor-erythroid 2-related factor-2 (Nrf2) via aryl　hydrocarbon receptor signaling pathway. Invited International conference

2011.5 

Aryl hydrocarbon receptor modulates keratinocyte differentiation by SIRT1 expression. International conference

G. Tsuji, M. Takahara, H. Uchi, S. Takeuchi, F. Yasukawa1, Y. Moroi, M. Furue

SID 71st Annual Meeting  2011.5 

An environmental contaminant, benzo(a)pyrene, induces oxidative stress mediated interleukin-8 production in human. International conference

Gaku Tsuji, Masakazu Takahara, Hiroshi Uchi, Satoshi Takeuchi, Fumiko Yasukawa, Yoichi Moroi, Masutaka Furue

The First Eastern Asia Dermatology Congress  2010.10 

Ketoconazole activates nuclear factor-erythroid 2-related factor-2 (Nrf2) via aryl hydrocarbon receptor signaling pathway. International conference

Gaku Tsuji, Masakazu Takahara, Tetsuo Matsuda, Hiroshi Uchi, Satoshi Takeuchi, Fumiko Yasukawa, Yoichi Moroi, Masutaka Furue

The First Eastern Asia Dermatology Congress  2010.9 

Ketoconazole activates nuclear factor-erythroid 2-related factor-2 (Nrf2) via aryl　hydrocarbon receptor signaling pathway. : A novel therapeutic approach for oxidative　stress. International conference

2010.9 

Molecular basis of anti-inflammatory effects by ketoconazole: A novel therapeutic　approach for oxidative stress. International conference

2010.8 

Ketoconazole activates nuclear factor-erythroid 2-related factor-2 (Nrf2) via aryl　hydrocarbon receptor signaling pathway. : A possible mechanism of antiinflammatory　effect. International conference

2010.5 

Benzo(a)pyrene induces expression of Interleukin-8 via aryl hydrocarbon receptor　signaling in normal human keratinocytes. International conference

2009.9 

Ketoconazole is an active modifier of aryl hydrocarbon receptor signaling pathway in　normal human keratinocytes. International conference

2009.5 

The environmental contaminant, benzo(a)pyrene induced Interleukin-8 by normal　human epidermal keratinocyte. International conference

2008.12 

Tubacin, a histone deacetylase 6 inhibitor, suppresses contact sensitivity via impairment of the immune synapse. International conference

Gaku Tsuji

International Investigative Dermatology 8th  2013.5 

Cynaropicrin, an extract from artichoke, inhibits UVB-induced oxidative stress in cultured human keratinocytes. International conference

Gaku Tsuji

Society of Investigative Dermatology 72nd Annual meeting  2012.5 

Steering committee member   Domestic

2017.4 - 2020.3   

九州真菌懇話会   世話人（九州大学）   Domestic

2017.4 - 2020.3   

Screening of academic papers

Role(s)： Peer review

2017

皮膚老化の新しいメカニズムに関する研究

2015.4 - 2021.3

共同研究

上皮成長因子受容体阻害薬によるざ瘡様発疹における芳香族炭化水素受容体の活性化

2015 - 2017

日本学術振興会  科学研究費助成事業  研究活動スタート支援

レドックスナビ研究拠点若手育成事業

2011.4 - 2012.4

表皮細胞バイオマーカーのクロストークと老化に関する研究

2011.1 - 2011.12

共同研究

AhRを介したNrf2・SIRT1活性化の機序の解析

2011

レドックスナビ研究拠点若手育成事業