2025/09/09 更新

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写真a

アシダ　ミワ
芦田 美輪
ASHIDA MIWA
所属
九州大学病院 油症ダイオキシン研究診療センター 助教
医学部 医学科（併任）
職名
助教
外部リンク

論文

  • Blood levels of neurotransmitters in Yusho patients: An approach via the descending pain inhibitory pathway for persistent sensory disturbance 査読

    Ashida, M; Murayama, N; Kamio, Y; Yozaki, M; Kuwatsuka, Y; Nakahara, T; Murota, H

    JOURNAL OF DERMATOLOGY   52 ( 5 )   934 - 938   2025年5月   （ ISSN:0385-2407 eISSN:1346-8138 ）

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    記述言語：英語   出版者・発行元：Journal of Dermatology  

    Yusho, a dioxin poisoning incident in Japan, has resulted in patients experiencing persistent symptoms, including sensory disturbances, decades after the initial exposure. This study investigated the potential involvement of the descending pain inhibitory system in Yusho patients. Serum serotonin, dopamine, and norepinephrine levels were measured in 29 Yusho patients and 29 age-matched healthy controls. No significant differences in these neurotransmitters were observed between the two groups. However, weak correlations were found between polychlorinated biphenyl levels and dopamine (r = 0.4310, p = 0.0315) in Yusho patients. This study provides new insights into the pathophysiology of cutaneous sensory disorders and highlights the need for further research to clarify the long-term effects of dioxin exposure on Yusho patients.

    DOI： 10.1111/1346-8138.17689

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