記述言語：英語  

DOI： 10.7759/cureus.62042

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PubMed

記述言語：英語   出版者・発行元：Clinical Anatomy  

Endoscopic endonasal skull base surgery is increasingly prevalent, with its scope expanding from pathogens in the midline region to those in the paramedian region. Maximizing anterior sphenoidectomy is important for the median approach, and lateralizing the pterygopalatine fossa is crucial for the paramedian approach. Maximizing the surgical corridor in the nasal cavity and minimizing damage to neurovascular structures are vital for establishing a surgical field with minimal bleeding, ensuring safe, precise, and gentle procedures. However, the relationship between the maxillofacial and skull base bones in endoscopic endonasal skull base surgery is difficult to understand because these bones are intricately articulated, making it challenging to visualize each bone's outline. Understanding important bones and their related neurovascular structures is essential for all skull base surgeons to maximize the surgical corridor and minimize iatrogenic injury to neurovascular structures. This study aimed to elucidate the role of the palatine bone from a microsurgical anatomical perspective. Three dry skulls were used to demonstrate the structure of the palatine bone and its relationship with surrounding bones. A formalin-perfused cadaveric head was dissected to show the related neurovascular structures. The arteries and veins of the cadaveric heads were injected with red- and blue-colored silicon. Dissection was performed using a surgical microscope and endoscope. In addition, the utilization of the palatine bone as a landmark to identify neurovascular structures, which aids in creating a wider surgical field with less bleeding, was shown in two representative cases. The palatine bone consists of unique complex structures, including the sphenoidal process, ethmoidal crest, pterygopalatine canal, and sphenopalatine notch, which are closely related to the sphenopalatine artery, maxillary nerve, and its branches. The ethmoidal crest of the palatine bone is a well-known structure that is useful for identifying the sphenopalatine foramen, controlling the sphenopalatine artery and nerve, and safely opening the pterygopalatine fossa. The sphenoidal process of the palatine bone is a valuable landmark for identifying the palatovaginal artery, which is a landmark used to safely and efficiently expose the vidian canal. The sphenoidal process is easily cracked with an osteotome and removed to expose the palatovaginal artery, which runs along the pharyngeal groove, just medial to the vidian canal. By opening the pterygopalatine canal (also known as the greater palatine canal), further lateralization of the periosteum-covered pterygopalatine fossa contents can be achieved. Overall, the sphenoidal process and ethmoidal crest can be used as important landmarks to maximize the surgical corridor and minimize unnecessary injury to neurovascular structures.

DOI： 10.1002/ca.24170

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PubMed

記述言語：英語   出版者・発行元：PNAS Nexus  

The activation and differentiation of B cells into plasma cells (PCs) play critical roles in the immune response to infections and autoimmune diseases. Toll-like receptor 9 (TLR9) responds to bacterial and viral DNA containing unmethylated CpG motifs and triggers immune responses in B cells; however, abnormal recognition of self-DNA by TLR9 can cause autoimmune diseases. When stimulated with TLR9 agonists, follicular (FO) B cells, a subset of B cells residing in the FO regions of secondary lymphoid organs, exhibit a propensity for activation but fail to give rise to PCs. The factors that enable the transition of TLR9-activated FO B cells from activation to differentiation into PCs remain unclear. In this study, we show that type I interferon-alpha (IFNα) signaling causes FO B cells activated by CpG stimulation to differentiate into PCs. Although CpG stimulation alone only temporarily increased interferon regulatory factor 4 (IRF4) expression in FO B cells, co-stimulation with both CpG and IFNα enhanced and maintained high IRF4 expression levels, ultimately enabling the cells to differentiate into PCs. Overexpression of IRF4 in FO B cells results in CpG-induced PC transition without IFN signaling. Furthermore, co-stimulation of TLR9 and IFNα receptors significantly enhanced mammalian target of rapamycin (mTOR) signaling, which regulates IRF4 expression and PC generation. These findings suggest that IFNα may play a key role in promoting the fate of PC differentiation in FO B cells activated by TLR9 stimulation.

DOI： 10.1093/pnasnexus/pgae152

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PubMed

記述言語：日本語   出版者・発行元：一般社団法人 日本耳鼻咽喉科頭頸部外科学会  

<p>　好酸球性副鼻腔炎は type2 炎症を主体とする難治性副鼻腔炎で, 内視鏡下鼻副鼻腔手術はその治療, 病勢コントロールの手段として大きな役割を果たしている. また近年, 内視鏡の発展は著しく, 画質もハイビジョンから 4K と高画質になり, またナビゲーションシステムや細径のシェーバーやドリルなどの機器や器具の進歩によって鼻副鼻腔の狭小部位 (前頭陥凹や嗅裂), 危険部位 (篩骨洞天蓋, 視神経管, 内頸動脈周囲など) においても安全で繊細な手術が可能となっている.</p><p>　本稿では, 好酸球性副鼻腔炎に対する内視鏡下鼻副鼻腔手術 (full house ESS: 病勢コントロールのために可能な限り cell の隔壁を切除し, 各副鼻腔を単洞化する手術) を対象とし, その鼻副鼻腔手術の中でも前頭陥凹 (frontal recess) の開放と中鼻道の癒着を防ぐ方法, central compartment である鼻中隔, 中鼻甲介, 上鼻甲介粘膜の浮腫状病変に対しての手術手技を中心にそのチップス, 筆者が大切にしていることを最近の知見をふまえ, 症例を提示し, 解説する.</p>

DOI： 10.3950/jibiinkotokeibu.126.12_1288

CiNii Research

記述言語：英語   出版者・発行元：Biomaterials  

Allergen immunotherapy (AIT) is the only curative treatment for allergic diseases. However, AIT has many disadvantages related to efficiency, safety, long-term duration, and patient compliance. Dendritic cells (DCs) have an important role in antigen-specific tolerance induction; thus, DC-targeting strategies to treat allergies such as glutaraldehyde crosslinked antigen to mannoprotein (MAN) have been established. However, glutaraldehyde crosslinking may reduce the antigen presentation efficiency of DCs. To overcome this, we developed a MAN-coated ovalbumin (OVA) nanoparticle (MDO), which uses intermolecular disulfide bond to crosslink OVA and MAN. MDO effectively targeted DCs resulting in tolerogenic DCs, and promoted higher antigen presentation efficiency by DCs compared with OVA or glutaraldehyde crosslinked nanoparticles. In vitro and in vivo experiments showed that DCs exposed to MDO induced Treg cells. Moreover, MDO had low reactivity with anti-OVA antibodies and did not induce anaphylaxis in allergic mice, demonstrating its high safety profile. In a mouse model of allergic asthma, MDO had significant preventative and therapeutic effects when administered orally or subcutaneously. Therefore, MDO represents a promising new approach for the efficient and safe treatment of allergies.

DOI： 10.1016/j.biomaterials.2023.122381

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   出版者・発行元：Journal of Colloid and Interface Science  

Nanoparticles (NPs) for allergen immunotherapy have garnered attention for their high efficiency and safety compared with naked antigen proteins. In this work, we present mannan-coated protein NPs, incorporating antigen proteins for antigen-specific tolerance induction. The heat-induced formation of protein NPs is a one-pot preparation method and can be applied to various proteins. Here, the NPs were formed spontaneously via heat denaturation of three component proteins: an antigen protein, human serum albumin (HSA) as a matrix protein, and mannoprotein (MAN) as a targeting ligand for dendritic cells (DCs). HSA is non-immunogenic, therefore suitable as a matrix protein, while MAN coats the surface of the NP. We applied this method to various antigen proteins and found that the self-disperse after heat denaturation was a requirement for incorporation into the NPs. We also established that the NPs could target DCs, and the incorporation of rapamycin into the NPs enhanced the induction of a tolerogenic phenotype of DC. The MAN coating provided steric hindrance and heat denaturation destroyed recognition structures, successfully preventing anti-antigen antibody binding, indicating the NPs may avoid anaphylaxis induction. The MAN-coated NPs proposed here, prepared by a simple method, have the potential for effective and safe allergies treatment for various antigens.

DOI： 10.1016/j.jcis.2023.06.170

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

DOI： 10.11334/jibi.69.5_398

CiNii Research

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

<p>症例は 18 歳、男性。3 年前に意識消失を伴うてんかん発作を発症、その後薬物治療を行うもてんかん発作を繰り返す状態であった。画像検査で中頭蓋窩から蝶形骨洞側窩に陥入する側頭葉の髄膜脳瘤を指摘され、側頭葉てんかんの焦点と考えられたため髄膜脳瘤切除目的に当院入院となった。経鼻内視鏡下に蝶形骨側窩の髄膜脳瘤を切除し、その後、有茎中鼻甲介粘膜弁を用いて多層での頭蓋底再建を行った。術後、てんかん発作は消失、髄液漏や創部の合併症なく経過している。蝶形骨洞側窩のように蝶口蓋孔近傍で限局した箇所であれば鼻中隔粘膜弁でなくても中鼻甲介粘膜弁での代用が可能で、minimal transpterygoid approach を用い、さらに蝶口蓋動脈とその分枝である中鼻甲介動脈を温存することで頭蓋底再建時に中鼻甲介粘膜弁の利用が可能となった。</p>

DOI： 10.11334/jibi.69.2_116

CiNii Research

記述言語：英語  

DOI： 10.7759/cureus.35932

Web of Science

PubMed

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

症例は18歳、男性。3年前に意識消失を伴うてんかん発作を発症、その後薬物治療を行うもてんかん発作を繰り返す状態であった。画像検査で中頭蓋窩から蝶形骨洞側窩に陥入する側頭葉の髄膜脳瘤を指摘され、側頭葉てんかんの焦点と考えられたため髄膜脳瘤切除目的に当院入院となった。経鼻内視鏡下に蝶形骨側窩の髄膜脳瘤を切除し、その後、有茎中鼻甲介粘膜弁を用いて多層での頭蓋底再建を行った。術後、てんかん発作は消失、髄液漏や創部の合併症なく経過している。蝶形骨洞側窩のように蝶口蓋孔近傍で限局した箇所であれば鼻中隔粘膜弁でなくても中鼻甲介粘膜弁での代用が可能で、minimal transpterygoid approachを用い、さらに蝶口蓋動脈とその分枝である中鼻甲介動脈を温存することで頭蓋底再建時に中鼻甲介粘膜弁の利用が可能となった。(著者抄録)

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

<p>2013 年 1 月から 2021 年 7 月の期間に手術治療を行った錐体尖病変 15 例を検討した。コレステリン肉芽腫 4 例では、1 例が経乳突的に、3 例は経鼻的にドレナージルートを作成した。錐体尖真珠腫 11 例では初発例 5 例、再手術例が 6 例であり、進展経路は迷路上型が 7 例、広範迷路型 2 例、迷路下型 2 例であった。迷路上型では進展範囲の小さな症例は経上半規管法により低侵襲に摘出し得たが、進展例や再手術例では中頭蓋窩法や、中頭蓋窩法と経迷路法の combined approach が必要であった。広範迷路型では経蝸牛 ＋ 中頭蓋窩法の combined approach を行い、迷路下型では進展範囲に応じて蝸牛下法や迷路下法を用いた。コレステリン肉芽腫全例と錐体尖真珠腫の 3 例で聴力温存できた。錐体尖は側頭骨最深部に位置し、手術アプローチの選択が重要である。聴力や病変と解剖学的構造の位置関係を考慮して術式を選択する必要がある。</p>

DOI： 10.11334/jibi.69.1_1

CiNii Research

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

2013年1月から2021年7月の期間に手術治療を行った錐体尖病変15例を検討した。コレステリン肉芽腫4例では、1例が経乳突的に、3例は経鼻的にドレナージルートを作成した。錐体尖真珠腫11例では初発例5例、再手術例が6例であり、進展経路は迷路上型が7例、広範迷路型2例、迷路下型2例であった。迷路上型では進展範囲の小さな症例は経上半規管法により低侵襲に摘出し得たが、進展例や再手術例では中頭蓋窩法や、中頭蓋窩法と経迷路法のcombined approachが必要であった。広範迷路型では経蝸牛+中頭蓋窩法のcombined approachを行い、迷路下型では進展範囲に応じて蝸牛下法や迷路下法を用いた。コレステリン肉芽腫全例と錐体尖真珠腫の3例で聴力温存できた。錐体尖は側頭骨最深部に位置し、手術アプローチの選択が重要である。聴力や病変と解剖学的構造の位置関係を考慮して術式を選択する必要がある。(著者抄録)

記述言語：英語   出版者・発行元：Pediatrics International  

Background: Stuttering is a childhood-onset fluency disorder. Part of the counseling for middle and high school students with persistent stuttering is related to school refusal. Anxiety disorders are known to contribute to school refusal. However, it is not known whether social anxiety disorder (SAD) is a factor in school refusal among adolescents who stutter. Methods: In our first study, we examined the relationship between school refusal and SAD in 84 middle and high school students who stutter; 26% of the 84 students were in the school refusal group and the remaining 74% were in the school attendance group. The second study examined whether SAD was associated with 10 factors related to speech and stuttering frequency using the Japanese version of the Liebowitz Social Anxiety Scale for Children and Adolescents to determine the presence of SAD. Of the 84 students in the first study, 40 participated in the second study. Results: The school refusal group of adolescents who stutter had significantly higher rates of SAD than the school attendance group. Fifty percent of adolescents who stutter met the criteria for SAD. Moreover, adolescents who stutter with SAD had significantly higher scores on the items “When speaking in public, do you experience tremors in your limbs?” and “After you stutter, do you have negative thoughts about yourself?” than the adolescents who stutter without SAD. Conclusions: When examining adolescents who stutter, checking for comorbid SAD may lead to better support. Moreover, noticing their repetitive negative thinking, nervousness, and trembling during speech may help to resolve SAD.

DOI： 10.1111/ped.15622

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記述言語：英語   出版者・発行元：John Wiley & Sons Australia, Ltd  

吃音を主訴として受診した中・高校生を対象に、不登校と社交不安障害(SAD)の関連について検討するとともに(研究1)、発話に関連する10項目とSADの関連について検討した(研究2)。研究1において、84名中22名(26%)が不登校群、62名(74%)が登校群であった。不登校群では登校群に比べてリボビッツ社交不安尺度(LSAS-CA)日本語版の得点が有意に高かった(p=0.004)。研究1の参加者のうち40名を対象とした研究2において、LSAS-CA日本語版による評価で40名中20名がSAD群、20名が非SAD群であった。SAD群では非SAD群に比べて「人前で話をする際に手足が震えることがありますか」および「吃音が出た後に自己否定する思考に陥ることがありますか」の項目の得点が有意に高かった。

出版者・発行元：東京医学社  

DOI： 10.24479/pm.0000000704

CiNii Research

記述言語：日本語   出版者・発行元：(公財)日本眼科学会  

背景:炎症性筋線維芽細胞性腫瘍(IMT)は筋線維芽細胞の増殖と炎症細胞浸潤を特徴とする中間悪性腫瘍であり,肺,腹腔骨盤内,後腹膜に好発し,眼窩に発生することはまれである.今回,眼窩に発生したIMTの1例を経験したので報告する.症例:46歳,女性.複視を主訴に近医眼科を受診し,眼窩に腫瘍を指摘され九州大学病院眼科を紹介受診した.初診時に右眼球結膜下の赤色調腫瘤および画像診断で右眼窩内下方に35×20×15mmの紡錘形腫瘤を認め,眼球運動障害を来していた.結膜下の腫瘤を生検したところ,炎症細胞浸潤を伴った紡錘形細胞の増殖を認めた.免疫染色の結果,増殖細胞はanaplastic lymphoma kinase(ALK),α-平滑筋アクチン(α-SMA),desmin陽性であり,IMTと診断した.結膜切開および鼻内視鏡下にアプローチして全摘出し,術後24ヵ月の現在,再発は認めていない.結論:眼窩腫瘍で非上皮性腫瘍を疑う際はIMTの可能性も検討する必要がある.(著者抄録)

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

DOI： 10.11334/jibi.68.4_318

CiNii Research

記述言語：英語   出版者・発行元：Auris Nasus Larynx  

Rapidly growing mycobacteria rarely causes parotitis. We report a rare case of Mycobacteroides abscessus subspecies abscessus (MAB) parotitis in a previously healthy 26-year-old woman. She presented to the previous hospital with a swelling over the right parotid region, and a computed tomography scan revealed multiple abscesses in the swollen parotid gland. Histopathology showed granulomatous inflammation with acid-fast bacilli; however, a subsequent culture failed to isolate mycobacterium. Despite repeated antibiotic therapy and multiple surgical interventions including partial incision and drainage of the abscesses, the parotitis did not resolved. At six months after presentation, she was referred to our institute. We performed enlarged resection of the necrotic tissue and abscesses, and the sample cultivated after homogenization was positive for mycobacterium. The isolate was finally identified as MAB. She underwent long-term postoperative antibiotic therapy for MAB, with a favorable outcome. To the best of our knowledge, this is the first case of MAB parotitis where the subspecies has been identified. MAB is much more intractable than the other subspecies. We highlight the importance of the correct identification of MAB, which leads to the appropriate treatment.

DOI： 10.1016/j.anl.2020.11.005

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記述言語：英語   出版者・発行元：(一社)日本耳鼻咽喉科頭頸部外科学会  

症例は26歳女性で、生来健康であったが、最近、活動性結核の患者と濃厚接触する機会があった。その後に右耳下腺領域に腫脹が生じたため近医を初診し、1週間後に総合病院へ紹介された。CT検査で耳下腺内の多発性膿瘍が示され、各種の抗生物質による集中治療を受けたが症状は改善しなかった。初診2ヵ月の膿瘍切開時に採取された組織検体では炎症性肉芽腫と類上皮細胞が認められ、加えてZiehl-Neelsen染色にて抗酸菌の存在も示された。PCR検査ではMycobacterium tuberculosisとの結果が得られ、培養検査は陰性であった。抗生物質、部分切開術、ドレナージによる治療を繰り返すも耳下腺炎は改善せず、初診から6ヵ月後に当院紹介となった。壊死組織と膿瘍の拡大切除術を施行したが、その際に得た切除検体をホモジナイズし抗酸菌用の培地で培養した。分離株をDNA-DNAハイブリダイゼーション法で分析した結果、M.abscessus subsp.abscessus(MAB)と同定された。感受性試験の結果に従い、抗生物質治療を長期間継続した。その結果、最後の手術から5ヵ月後のCT評価にて耳下腺炎と腺内膿瘍の消退が確かめられ、その後も再発しなかった。外傷など、MABの侵入経路として考えられるものは本例では判然としなかった。

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.anl.2020.12.009

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： doi: 10.1111/ped.14405.

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Sinusitis is a serious infectious complication of allogeneic hematopoietic stem cell transplantation. Schizophyllum commune (S commune) is a common basidiomycete fungus that is rarely involved in human disease. We report herein a case of S commune sinusitis after allogeneic bone marrow transplantation. A 66-year-old man with myelodysplastic syndrome underwent allogeneic bone marrow transplantation and developed maxillary and ethmoid sinusitis. The sinusitis did not improve with liposomal amphotericin B after neutrophil engraftment, so we considered that surgical intervention was needed for the recovery of sinusitis. Endoscopic sinus surgery was performed. In the debridement tissue of paranasal mucosa, filamentous fungal elements were observed. Moreover, genetic analysis of the tissue revealed the presence of S commune. Schizophyllum commune should be recognized as a fungal pathogen that causes sinusitis after allogeneic hematopoietic stem cell transplantation. This case suggests the effectiveness of prompt surgical intervention with liposomal amphotericin B treatment for S commune sinusitis and the usefulness of genetic diagnosis for cases under antifungal treatment. (160 words).

DOI： 10.1111/tid.13205

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3960/jslrt.18008

記述言語：英語   掲載種別：研究論文（学術雑誌）  

The recent emergence of antibiotic-resistant bacteria requires the development of new antibiotics or new agents capable of enhancing antibiotic activity. This study evaluated the antibacterial activity of lysozyme-chitosan oligosaccharide conjugates (LYZOX) against Pseudomonas aeruginosa, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), which should resolve the problem of antibiotic-resistant bacteria. Bactericidal tests showed that LYZOX killed 50% more P. aeruginosa (NBRC 13275), A. baumannii and MRSA than the control treatment after 60 min. In addition, LYZOX was shown to inhibit the growth of P. aeruginosa (NBRC 13275 and PAO1), A. baumannii and MRSA better than its components. To elucidate the antibacterial mechanism of LYZOX, we performed cell membrane integrity assays, N-phenyl-1-naphthylamine assays, 2-nitrophenyl β-D-galactopyranoside assays and confocal laser scanning microscopy. These results showed that LYZOX affected bacterial cell walls and increased the permeability of the outer membrane and the plasma membrane. Furthermore, each type of bacteria treated with LYZOX was observed by electron microscopy. Electron micrographs revealed that these bacteria had the morphological features of both lysozyme-treated and chitosan oligosaccharide- treated bacteria and that LYZOX destroyed bacterial cell walls, which caused the release of intracellular contents from cells. An acquired drug resistance test revealed that these bacteria were not able to acquire resistance to LYZOX. The hemolytic toxicity test demonstrated the low hemolytic activity of LYZOX. In conclusion, LYZOX exhibited antibacterial activity and low drug resistance in the presence of P. aeruginosa, A. baumannii and MRSA and showed low hemolytic toxicity. LYZOX affected bacterial membranes, leading to membrane disruption and the release of intracellular contents and consequent bacterial cell death. LYZOX may serve as a novel candidate drug that could be used for the control of refractory infections.

DOI： 10.1371/journal.pone.0217504

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective. The number of patients with type 2 diabetes has increased in Japan, and type 2 diabetes has attracted attention as a risk factor for asthma. However, the risk factors for the development of asthma in patients with type 2 diabetes have not been determined. This study was performed to clarify whether visceral fat accumulation (VFA) and insulin resistance are risk factors for the development of asthma in patients with type 2 diabetes. Materials and Methods. A cross-sectional study was conducted. The study group comprised 15 patients with type 2 diabetes with asthma, and the control group comprised 145 patients with type 2 diabetes without asthma. Their fat distribution was evaluated by measuring the VFA by abdominal computed tomography at the umbilical level. Their glucose status was assessed by measuring the fasting plasma glucose (FPG) concentration, fasting immunoreactive insulin concentration, homeostasis model assessment (HOMA) index, and hemoglobin A1c concentration. Results. Among patients with type 2 diabetes, VFA was significantly greater in patients with asthma than those without asthma (P < 0 0001). The FPG concentration, fasting immunoreactive insulin concentration, and HOMA index were higher in patients with asthma than those without asthma (P < 0 05, P < 0 0001, and P < 0 0001, respectively). Multiple logistic regression analysis showed that VFA and the HOMA index were significantly associated with asthma in patients with type 2 diabetes (odds ratio, 1.78; 95% confidence interval, 1.31-3.89; P = 0 0115 and odds ratio, 3.65; 95% confidence interval, 1.37-7.85; P = 0 0078, respectively). Conclusions. Our data suggest that VFA and insulin resistance are associated with the development of asthma in patients with type 2 diabetes.

DOI： 10.1155/2019/3129286

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Both developmental and acquired stuttering are related to the function of the basal ganglia-thalamocortical loop, which includes the putamen. Here, we present a case of stuttering- and palilalia-like dysfluencies that manifested as an early symptom of multiple system atrophy-parkinsonian type (MSA-P) and bilateral atrophy of the putamen. The patient was a 72-year-old man with no history of developmental stuttering who presented with a stutter for consultation with our otorhinolaryngology department. The patient was diagnosed with MSA-P based on parkinsonism, autonomic dysfunction, and bilateral putaminal atrophy revealed by T2-weighted magnetic resonance imaging. Treatment with levodopa improved both the motor functional deficits related to MSA-P and stuttering-like dysfluencies while reading; however, the palilalia-like dysfluencies were much less responsive to levodopa therapy. The patient died of aspiration pneumonia two years after his first consultation at our hospital. In conclusion, adult-onset stuttering- and palilalia-like dysfluencies warrant careful examination of the basal ganglia-thalamocortical loop, and especially the putamen, using neuroimaging techniques. Acquired stuttering may be related to deficits in dopaminergic function.

DOI： 10.1016/j.jfludis.2017.11.002

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Current allergen-specific immunotherapy (AIT) for pollinosis requires long-term treatment with potentially severe side effects. Therefore, development of an AIT that is safe and more convenient with a shorter regimen is needed. This prospective, double-blind, placebo-controlled trial randomized 55 participants with Japanese cedar pollinosis (JCP) to active or placebo groups to test the safety and efficacy of short-term oral immunotherapy (OIT) with Cry j 1-galactomannan conjugate for JCP. Mean symptom-medication score as the primary outcome in the active group improved 27.8% relative to the placebo group during the entire pollen season. As the secondary outcomes, mean medication score in active group improved significantly, by 56.2%, compared with placebo during the entire pollen season. Mean total symptom score was similar between active and placebo groups during the entire pollen season. There were no severe treatment-emergent adverse events in the active and placebo groups. Therefore short-term OIT with Cry j 1-galactomannan conjugate is safe, and effective for reducing the amount of medication use for JCP.

DOI： 10.1038/srep46142

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Eosinophilic otitis media and sinusitis are intractable disorders characterized by eosinophilic inflammation associated with bronchial asthma, which can be considered as a unified airway disease rather than as disorders with localized eosinophilic inflammation. The production of eosinophilic mucin and emergence of antibiotic-resistant bacteria at the site of inflammation are factors that make it difficult to treat eosinophilic otitis media and sinusitis. Therefore, development of a new topical agent with adequate antibacterial activity against the antibiotic-resistant bacteria and adequate efficacy for removing the viscous mucin is being sought. Therefore, we focused on lysozyme, which has already been used as a medical preparation, with its anti-inflammatory effects and antibacterial activity against some Gram-positive bacteria. In this study, we developed lysozyme-polysaccharide conjugates using the Maillard reaction to improve the aforementioned activities and examined the antibacterial activity against antibiotic-resistant bacteria and the inner ear toxicity of lysozyme-polysaccharide conjugates, for potential development of a cleaning agent for the middle ear. Testing of the antibacterial activity of lysozyme-chitosan conjugate showed antibacterial activities against MRSA and P. aeruginosa. In addition, the inner ear toxicity study in Guinea pigs revealed no obvious inner ear toxicity. Therefore lysozyme-chitosan conjugate are useful as a topical therapeutic agent (cleaning agent) and their clinical application is expected in the future.

DOI： 10.5631/jibirin.109.822

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3950/jibiinkoka.119.1263

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.alit.2014.10.009

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: The purpose of this study was to evaluate the effectiveness of the combination of inferior and middle meatal antrostomies for treatment of a maxillary sinus fungus ball by functional endoscopic sinus surgery. Methods: A retrospective analysis including 28 patients with non-invasive fungal maxillary sinusitis was performed. Fourteen patients underwent FESS with both middle and inferior meatal antrostomies (combined group). The remaining 14 patients were treated with FESS through only the middle meatal antrostomy (control group). Results: Post-operative computed tomography showed normal maxillary sinuses in all patients in the combined group. In contrast, in the control group, five patients (36 per cent) exhibited a normal maxillary sinus, seven (50 per cent) showed maxillary mucosal thickening and two (14 per cent) had persistent fungus balls in the maxillary sinus. Conclusion: FESS with a combination of middle and inferior meatal antrostomies proved more effective for treating fungal maxillary sinusitis.

DOI： 10.1017/S0022215114002394

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: The present study investigates the indications for transnasal endoscopic surgery in treating post-operative maxillary cysts. Methods: In this retrospective study, the records of 118 patients with post-operative maxillary cysts (88 unilateral and 30 bilateral) consisting of 148 procedures were reviewed. Results: A transnasal endoscopic approach was performed in 144 lesions (97.3 per cent). A combined endonasal endoscopic and canine fossa (external) approach was performed in 4 of 148 lesions, because the cysts were located distant from the nasal cavity and had a thick bony wall. A ventilation stent was placed in four patients (four cysts) to avoid post-operative meatal antrostomy stenosis. Recurrence was observed in five patients (4.2 per cent), all of whom subsequently underwent transnasal endoscopic revision surgery. Conclusion: Transnasal endoscopic surgery is an effective treatment for post-operative maxillary cyst with the exception of cysts located distant from the nasal cavity.

DOI： 10.1017/S0022215114002382

記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1016/j.anl.2014.02.010

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Thyroid carcinomas with massive intralumen invasion of the great veins are extremely rare and reported to have poor prognosis. We report a case of a poorly differentiated follicular carcinoma of the thyroid with extensive invasion into the bilateral internal jugular veins, brachiocephalic vein, and superior vena cava. All of the seven major drainage veins from the thyroid were involved by tumor thrombus. The patient was successfully treated by surgical resection including removal of the tumor thrombus and repair of the great veins. The importance of preoperative radiological findings, treatment, and outcome are discussed along with a literature review.

DOI： 10.1002/lary.23690

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

記述言語：日本語   掲載種別：研究論文（学術雑誌）  

掲載種別：研究論文（学術雑誌）  

記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background: Allergic rhinitis is one of the most common allergic inflammatory diseases characterized by a predominant T _H2 response with antigen-specific IgE synthesis. IL-15 plays important roles in activation and maintenance of memory CD8 ⁺T cells capable of producing IFN-γ, which regulates T _H2 responses. Objective: To investigate the roles of endogenous IL-15 in allergic inflammation, we examined allergic rhinitis in IL-15 knockout (KO) mice sensitized with ovalbumin followed by intranasal rechallenge with ovalbumin. Methods: IL-15KO mice were sensitized intraperitoneally with ovalbumin/complete Freund's adjuvant on day 0 and ovalbumin/IFA on day 7, and then were intranasally challenged with ovalbumin on days 21, 22, 23, 24, and 25. Nasal symptoms and histologic changes were examined. IgE production and T _H2 responses were measured by ELISA. Purified CD8 ⁺T cells or recombinant IL-15 were administered into ovalbumin-sensitized mice. Results: The levels of IgE production and T _H2 responses in IL-15KO mice were comparable to those in control mice after ovalbumin sensitization. However, sneezing, infiltration of eosinophils into the nasal mucosa, and T _H2 cytokine production were aggravated in ovalbumin-sensitized IL-15KO mice after intranasal challenge with ovalbumin. Adoptive transfer of CD8 ⁺ T cells from ovalbumin-sensitized mice suppressed the T _H2 responses in mice but not in IL-15KO mice. Administration of IL-15 with ovalbumin significantly prevented the development of allergic rhinitis in ovalbumin-sensitized mice. Conclusion: We demonstrate with IL-15KO mice that endogenous IL-15 plays an important role in suppression of allergic rhinitis at effector phase. Intranasal administration of IL-15 is useful as a therapeutic approach to control allergic rhinitis. Clinical implications: Intranasal administration of recombinant IL-15 might become new immunotherapy for allergic rhinitis.

DOI： 10.1016/j.jaci.2006.02.018

開催年月日： 2022年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：金沢市文化ホール   国名：日本国  

開催年月日： 2021年9月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：琵琶湖ホテル   国名：日本国  

開催年月日： 2021年5月

記述言語：日本語  

開催地：国立京都国際会館   国名：日本国  

開催年月日： 2019年10月

記述言語：日本語   会議種別：口頭発表（一般）  

開催地：都市センターホテル　東京   国名：日本国  

開催年月日： 2019年7月

記述言語：日本語   会議種別：口頭発表（招待・特別）  

開催地：西鉄グランドホテル　福岡市   国名：日本国  

開催年月日： 2018年9月

記述言語：日本語   会議種別：口頭発表（一般）  

国名：日本国  

開催年月日： 2017年10月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：ホテルメトロポリタン盛岡ニューウイング   国名：日本国  

開催年月日： 2017年9月

記述言語：日本語  

開催地：山梨県甲府市　甲府富士屋ホテル   国名：日本国  

開催年月日： 2017年2月

記述言語：日本語  

国名：日本国  

開催年月日： 2016年10月 - 2017年10月

記述言語：日本語  

国名：日本国  

開催年月日： 2016年6月 - 2017年6月

記述言語：日本語   会議種別：シンポジウム・ワークショップ パネル（公募）  

開催地：城山観光ホテル   国名：日本国  

開催年月日： 2011年5月

会議種別：口頭発表（一般）  

開催地：京都　国立京都国際会館   国名：日本国  

開催年月日： 2010年8月

会議種別：口頭発表（一般）  

開催地：札幌　札幌コンベンションセンター   国名：日本国  

開催年月日： 2010年5月

会議種別：口頭発表（一般）  

開催地：福岡　福岡大学8号館   国名：日本国  

開催年月日： 2009年10月

会議種別：口頭発表（一般）  

開催地：東京　京王プラザホテル   国名：日本国  

記述言語：英語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：英語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   出版者・発行元：(株)東京医学社  

記述言語：日本語   出版者・発行元：耳鼻と臨床会  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

DOI： https://doi.org/10.11334/jibi.66.1_28

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：英語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

記述言語：日本語   掲載種別：記事・総説・解説・論説等（学術雑誌）  

種別：大会・シンポジウム等 

参加者数：20

種別：査読等 

日本語雑誌　査読論文数：1

種別：大会・シンポジウム等 

参加者数：20

種別：大会・シンポジウム等 

参加者数：400

種別：査読等 

日本語雑誌　査読論文数：1

種別：査読等 

日本語雑誌　査読論文数：6

種別：学会・研究会等 

種別：学会・研究会等 

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：セミナー・ワークショップ

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

対象：社会人・一般,　学術団体,　企業,　市民団体,　行政機関

種別：講演会

「とっても健康らんど」副鼻腔炎

テレビとっても健康ランド　花粉症

花粉症　治療法は　舌下免疫療法　効果１～２年後　個人差も