Updated on 2024/11/25

Information

 

写真a

 
ANDO KOJI
 
Organization
Kyushu University Hospital Gastrointestinal Surgery (2) Lecturer
Kyushu University Hospital Gastrointestinal Surgery (2)(Concurrent)
Title
Lecturer
Contact information
メールアドレス
Tel
0926425466
Profile
・Department of Surgery and Sciences, Graduate School of Medicine, Kyushu University (April 2011-present) After studying molecularbiology in Chiba Cancer Center, moved back to Kyushu University. As an assistant professor, performed many gastroenterological operation, including esophagectomy and reconstruction, laparoscopic gastrectomy and laparoscopic colectomy. Also managed chemotherapy patients including many clinical trials. Involved in palliative care to terminal stage cancer patients. ・Chiba Cancer Center Research Institute (April 2009-March 2011, Supervisor Akira Nakagawara) Investigated the mechanism of KIF1Bβ, the 1p36 tumor suppressor, responsible for the alteration of mitochondrial morphologenesis. ・Department of Surgery and Sciences, Graduate School of Medicine, Kyushu University (April 2006-March 2010, Prof. Yoshihiko Maehara) To better understand surgery and cancer biology, entered the graduate school after the completion of training as a resident. Worked in surgery department for one year to learn how to deal with cancer patients. The second year, worked on DNA ploidy and spindle assembly checkpoint (SAC) in gastric cancers and found that abnormal expression of BUBR1, one of the proteins in SAC, resulted in DNA aneuploidy. ・Saiseikai Fukuoka General Hospital (April 2004- March 2006) As a resident worked in many departments including internal medicine, obstetrics and gynecology, pediatrics, and ER. Had an interest in gastroenterological surgery. ・Kyushu University School of Medicine (April 1998- March 2004) Experienced DNA cloning in a laboratory of basic science (sponsor; Yusaku Nakabeppu). Managed Kendo club as a captain. Passed the National Examination for Medical Practitioners, and received the medical license.

Degree

  • MD, PhD

Research History

  • 済生会福岡総合病院(臨床研修医) 千葉県がんセンター 研究局

    済生会福岡総合病院(臨床研修医) 千葉県がんセンター 研究局

Research Interests・Research Keywords

  • Research theme:Developing a new strategy to improve the effect of irinotecan

    Keyword:Irinotecan, topoisomerase I, proteasome inhibitor

    Research period: 2019.5 - 2021.5

  • Research theme:Significance of chromosomal instability in gastrointestinal tract cancers.

    Keyword:chromosomal instability, GI-tract cancers, spindle assembly checkpoint

    Research period: 2014.4 - 2019.3

  • Research theme:Development of new biomarker to detect sensitivity of CPT-11 in colorectal cancer.

    Keyword:colorectal cancer, sensitivity, CPT-11, Topo I

    Research period: 2014.4 - 2019.3

Awards

  • 武田科学振興財団医学系研究助成がん領域 研究助成

    2020.11   武田科学振興財団   血中遊離消化器がん細胞の新規かつ確実な回収法の開発および治療への応用

  • 日本癌治療学会 研究奨励賞

    2018.10   日本癌治療学会   A prospective study of XELIRI plus bevacizumab as a first-line therapy in Japanese patients with unresectable or recurrent colorectal cancer (KSCC1101)

  • 国際外科学会Young Investigator Award

    2014.6   国際外科学会   Pure Laparoscopic Simultaneous Resection of colorectal cancer and liver metastases

  • 日本サイトメトリー学会研究奨励賞

    2011.11   日本サイトメトリー学会   消化器癌におけるDNA aneuploidyの意義についての研究

  • 消化器癌発生学会研究奨励賞

    2011.11   消化器癌発生学会   シャペロンタンパク質Mortalinとがん抑制タンパク質p53の関連に着目した新たな抗がん剤の開発

Papers

  • Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors. Reviewed International journal

    Ando K, Tohme YH, Srinivasiah A, Taylor-Parker J, Harrington Y, Shah AK, @Oki E, Brahmandam M, Bharti AK.

    J Histochem Cytochem.   2018.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Reviewed International journal

    Ando K, Shah AK, Sachdev V, Kleinstiver BP, Taylor-Parker J, Welch MM, Hu Y, Salgia R, White FM, Parvin JD, Ozonoff A, Rameh LE, Joung JK, Bharti AK.

    Oncotarget   2017.7

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    DOI: 10.18632/oncotarget.16376.

  • Phase II study of long-course chemoradiotherapy followed by consolidation chemotherapy as total neoadjuvant therapy in locally advanced rectal cancer in Japan: ENSEMBLE-2

    Kagawa, Y; Ando, K; Uemura, M; Watanabe, J; Oba, K; Emi, Y; Matsuhashi, N; Izawa, N; Muto, O; Kinjo, T; Takemasa, I; Oki, E

    ANNALS OF GASTROENTEROLOGICAL SURGERY   8 ( 6 )   1067 - 1075   2024.11   ISSN:2475-0328

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    Language:English   Publisher:Annals of Gastroenterological Surgery  

    Aim: To evaluate the feasibility and safety of total neoadjuvant therapy with long-course chemoradiotherapy followed by consolidation chemotherapy in Japanese patients with locally advanced rectal cancer. Methods: This prospective, multicenter, single-arm, phase II trial was conducted at 10 centers. The eligibility criteria included age ≥20 y, locally advanced rectal cancer within 12 cm of the anal verge, and cT3-4N0M or TanyN+M0 at diagnosis, enabling curative resection. The protocol treatment was capecitabine (1650 mg/m2/day)-based long-course chemoradiotherapy (50.4 Gy/28 fractions) and consolidation chemotherapy (CAPOX, four courses) followed by total mesorectal excision. Nonoperative management was allowed if a clinical complete response was achieved. The primary endpoint was the pathologic complete response rate. Results: Among 28 enrolled patients (19 men, 9 women; median age, 69.5 [41–79] y), the long-course chemoradiotherapy and consolidation chemotherapy completion rates were 100% and 96.4%, respectively. The clinical responses included clinical complete response, (35.7%, 10/28), near-complete response (28.6%, 8/28), and incomplete response (32.1%, 9/28). Total mesorectal excision and nonoperative management were performed in 21 and six patients, respectively. The final analysis included 21 patients. Five patients (23.8% [90% confidence interval 11.8%–41.8%]) achieved pathologic complete response, while 10 of 28 patients (35.7%) achieved a pathological complete response or a sustained clinical complete response. No treatment-related deaths occurred. Grade ≥3 adverse events included diarrhea (7.1%) and leukopenia (7.1%). Conclusion: ENSEMBLE-2 demonstrated comparable pathologic complete response rates and well-tolerated safety of total neoadjuvant therapy with long-course chemoradiotherapy followed by consolidation chemotherapy in Japanese patients with locally advanced rectal cancer.

    DOI: 10.1002/ags3.12848

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  • Survival benefit of adjuvant chemotherapy based on molecular residual disease detection in resected colorectal liver metastases: subgroup analysis from CIRCULATE-Japan GALAXY

    Kataoka K., Mori K., Nakamura Y., Watanabe J., Akazawa N., Hirata K., Yokota M., Kato K., Kotaka M., Yamazaki K., Kagawa Y., Mishima S., Ando K., Miyo M., Yukami H., Laliotis G., Sharma S., Palsuledesai C.C., Rabinowitz M., Jurdi A., Liu M.C., Aleshin A., Kotani D., Bando H., Taniguchi H., Takemasa I., Kato T., Yoshino T., Oki E.

    Annals of Oncology   35 ( 11 )   1015 - 1025   2024.11   ISSN:09237534

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    Background: The prognostic role of circulating tumor DNA (ctDNA)-based molecular residual disease (MRD) detection and its utility for postsurgical risk stratification has been reported in colorectal cancer. In this study, we explored the use of ctDNA-based MRD detection in patients with colorectal liver metastases (CLM), for whom the survival benefit of adjuvant chemotherapy (ACT) after surgical resection remains unclear. Methods: Patients with CLM without extrahepatic disease from the GALAXY study (UMIN000039205) were included. The disease-free survival (DFS) benefit of ACT was evaluated in MRD-positive and -negative groups after adjusting for age, gender, number, and size of liver metastases, RAS status, and previous history of oxaliplatin for primary cancer. ctDNA was detected using a personalized, tumor-informed 16-plex polymerase chain reaction-next-generation sequencing (mPCR-NGS) assay. ctDNA-based MRD status was evaluated 2-10 weeks after curative surgery, before the start of ACT. Results: Among 6061 patients registered in GALAXY, 190 surgically resected CLM patients without any preoperative chemotherapy were included with a median follow-up of 24 months (1-48 months). ctDNA positivity in the MRD window was 32.1% (61/190). ACT was administered to 25.1% (48/190) of patients. In the MRD-positive group, 24-month DFS was higher for patients treated with ACT [33.3% versus not reached, adjusted hazard ratio (HR): 0.07, P < 0.0001]; whereas no benefit of ACT was seen in the MRD-negative group (24-month DFS: 72.3% versus 62.2%, adjusted HR: 0.68, P = 0.371). Multivariate analysis showed that the size of liver metastases (HR: 3.94, P = 0.031) was prognostic of DFS in the MRD-positive group. In the MRD-negative group, however, none of the clinicopathological factors were prognostic of DFS. Conclusions: Our data suggest that ACT may offer notable clinical benefits in MRD-positive patients with CLM. MRD status-based risk stratification could be potentially incorporated in future clinical trials for CLM.

    DOI: 10.1016/j.annonc.2024.08.2240

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  • DNA-dependent protein kinase inhibitor as a sensitizer of radiotherapy in locally advanced rectal cancer.

    Kagawa Y, Watanabe J, Ando K

    Journal of gastrointestinal oncology   15 ( 5 )   2358 - 2362   2024.10   ISSN:2078-6891

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    DOI: 10.21037/jgo-24-373

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  • RAS mutant transverse colon cancer with multiple liver metastases achieving long-term disease-free survival with postoperative maintenance therapy with aflibercept plus FOLFIRI and four repeated radical resections: a case report

    Tanaka, Y; Nakanishi, R; Sato, S; Otake, A; Ryujin, K; Ikeda, S; Ebata, Y; Harima, T; Natsugoe, K; Yoshiyama, T; Shin, Y; Kawazoe, T; Kudo, K; Zaitsu, Y; Hisamatsu, Y; Ando, K; Nakashima, Y; Itoh, S; Oki, E; Oda, Y; Yoshizumi, T

    SURGICAL CASE REPORTS   10 ( 1 )   231   2024.10   ISSN:2198-7793

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  • ctDNA-based molecular residual disease and survival in resectable colorectal cancer

    Nakamura, Y; Watanabe, J; Akazawa, N; Hirata, K; Kataoka, K; Yokota, M; Kato, K; Kotaka, M; Kagawa, Y; Yeh, KH; Mishima, S; Yukami, H; Ando, K; Miyo, M; Misumi, T; Yamazaki, K; Ebi, H; Okita, K; Hamabe, A; Sokuoka, H; Kobayashi, S; Laliotis, G; Aushev, VN; Sharma, S; Jurdi, A; Liu, MC; Aleshin, A; Rabinowitz, M; Bando, H; Taniguchi, H; Takemasa, I; Kato, T; Kotani, D; Mori, M; Yoshino, T; Oki, E

    NATURE MEDICINE   30 ( 11 )   3272 - 3283   2024.9   ISSN:1078-8956 eISSN:1546-170X

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  • Clinical Impact of Skeletal Muscle Mass and Nutritional Status in Patients with Recurrent or Advanced Gastric Cancer Treated with Nivolumab

    Hu, QJ; Kudo, K; Yukaya, T; Hasuda, H; Nakanishi, R; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Koga, T; Kusumoto, T; Oki, E; Yoshizumi, T

    ONCOLOGY   1 - 9   2024.9   ISSN:0030-2414 eISSN:1423-0232

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  • A multicenter single-arm phase II study examining the efficacy of TNT for locally advanced rectal cancer: ENSEMBLE-2.

    Ando, K; Kagawa, Y; Uemura, M; Watanabe, J; Miyo, M; Emi, Y; Matsuhashi, N; Izawa, N; Muto, O; Kinjo, T; Nishizawa, Y; Hata, T; Suwa, Y; Honboh, T; Tajima, JY; Sunakawa, Y; Oba, K; Takemasa, I; Oki, E

    JOURNAL OF CLINICAL ONCOLOGY   42 ( 16 )   2024.6   ISSN:0732-183X eISSN:1527-7755

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  • Plasma Angiogenic Factors as Predictors of the Efficacy of Second-line Chemotherapy Combined with Angiogenesis Inhibitors in Metastatic Colorectal Cancer: Results From the GI-SCREEN CRC-Ukit Study

    Yuki, S; Yamazaki, K; Sunakawa, Y; Taniguchi, H; Bando, H; Shiozawa, M; Nishina, T; Yasui, H; Kanazawa, A; Ando, K; Horita, Y; Goto, M; Okano, N; Moriwaki, T; Satoh, T; Tsuji, A; Yamashita, K; Asano, C; Abe, Y; Nomura, S; Yoshino, T

    CLINICAL COLORECTAL CANCER   23 ( 2 )   147 - 159.e7   2024.6   ISSN:1533-0028 eISSN:1938-0674

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    Language:English   Publisher:Clinical Colorectal Cancer  

    Background: The significance of angiogenic factors as predictors of second-line (2L) chemotherapy efficacy when combined with angiogenesis inhibitors for metastatic colorectal cancer (mCRC) remains unestablished. Patients and Methods: In this multicenter prospective observational study, 17 angiogenic factors were analyzed in plasma samples collected at pretreatment and progression stages using a Luminex multiplex assay. Patients who received chemotherapy plus bevacizumab (BEV group), FOLFIRI plus ramucirumab (RAM group), or FOLFIRI plus aflibercept (AFL group) as the 2L treatment were included. Interactions between pretreatment and treatment groups for progression-free survival (PFS), overall survival (OS), and response rate (RR) were assessed using the propensity-score weighted Cox proportional hazards model. Results: From February 2018 to September 2020, 283 patients were analyzed in the 2L cohort. A strong interaction was observed for PFS between BEV and RAM with HGF, sNeuropilin-1, sVEGFR-1, and sVEGFR-3. Interactions for RR between the BEV and RAM groups were observed for sNeuropilin-1 and sVEGFR-1. Contrarily, OS, PlGF, sVEGFR-1, and sVEGFR-3 differentiated the treatment effect between BEV and AFL. Plasma samples were evaluable for dynamic analysis in 203 patients. At progression, VEGF-A levels significantly decreased in the BEV group and increased in the RAM and AFL groups. Conclusion: The pretreatment plasma sVEGFR-1 and sVEGFR-3 levels could be predictive biomarkers for distinguishing BEV and RAM when combined with chemotherapy in 2L mCRC treatment. Based on the VEGF-A dynamics at progression, selecting RAM or AFL for patients with significantly elevated VEGF-A levels may be a 2L treatment strategy, with BEV considered for the third-line treatment. Clinical Trial Number: UMIN000028616

    DOI: 10.1016/j.clcc.2024.01.003

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  • Long-term survival and functional outcomes of laparoscopic surgery for clinical stage I ultra-low rectal cancers located within 5 cm of the anal verge: A prospective phase II trial (Ultimate trial).

    Ito M, Tsukada Y, Watanabe J, Fukunaga Y, Hirano Y, Sakamoto K, Hamamoto H, Yoshimitsu M, Horie H, Matsuhashi N, Kuriu Y, Nagai S, Hamada M, Yoshioka S, Ohnuma S, Hayama T, Otsuka K, Inoue Y, Ueda K, Toiyama Y, Maruyama S, Yamaguchi S, Tanaka K, Suzuki M, Naitoh T, Ando K, Watanabe M, Ultimate Trial Group

    Annals of surgery   2024.4   ISSN:0003-4932

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    DOI: 10.1097/SLA.0000000000006290

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  • Field experiment of a telesurgery system using a surgical robot with haptic feedback

    Ota, M; Oki, E; Nakanoko, T; Tanaka, Y; Toyota, S; Hu, QJ; Nakaji, Y; Nakanishi, R; Ando, K; Kimura, Y; Hisamatsu, Y; Mimori, K; Takahashi, Y; Morohashi, H; Kanno, T; Tadano, K; Kawashima, K; Takano, H; Ebihara, Y; Shiota, M; Inokuchi, J; Eto, M; Yoshizumi, T; Hakamada, K; Hirano, S; Mori, M

    SURGERY TODAY   54 ( 4 )   375 - 381   2024.4   ISSN:0941-1291 eISSN:1436-2813

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    Purpose: To verify the usefulness of haptic feedback in telesurgery and improve the safety of telerobotic surgery. Methods: The surgeon's console was installed at two sites (Fukuoka and Beppu; 140 km apart), and the patient cart was installed in Fukuoka. During the experiment, the surgeon was blinded to the haptic feedback levels and asked to grasp the intestinal tract in an animal model. The surgeon then performed the tasks at each location. Results: No marked differences in task accuracy or average grasping force were observed between the surgeon locations. However, the average task completion time was significantly longer, and the system usability scale (SUS) was significantly lower rating for remote operations than for local ones. No marked differences in task accuracy or task completion time were observed between the haptic feedback levels. However, with haptic feedback, the organ was grasped with a significantly weaker force than that without it. Furthermore, with haptic feedback, experienced surgeons in robotic surgery tended to perform an equivalent task with weaker grasping forces than inexperienced surgeons. Conclusion: The haptic feedback function is a tool that allows the surgeon to perform surgery with an appropriate grasping force, both on site and remotely. Improved safety is necessary in telesurgery; haptic feedback will thus be an essential technology in robotic telesurgery going forward.

    DOI: 10.1007/s00595-023-02732-7

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  • 触覚フィードバック付き手術ロボットを用いた遠隔手術システムのフィールド実験(Field experiment of a telesurgery system using a surgical robot with haptic feedback)

    Ota Mitsuhiko, Oki Eiji, Nakanoko Tomonori, Tanaka Yasushi, Toyota Satoshi, Hu Qingjiang, Nakaji Yu, Nakanishi Ryota, Ando Koji, Kimura Yasue, Hisamatsu Yuichi, Mimori Koshi, Takahashi Yoshiya, Morohashi Hajime, Kanno Takahiro, Tadano Kotaro, Kawashima Kenji, Takano Hironobu, Ebihara Yuma, Shiota Masaki, Inokuchi Junichi, Eto Masatoshi, Yoshizumi Tomoharu, Hakamada Kenichi, Hirano Satoshi, Mori Masaki

    Surgery Today   54 ( 4 )   375 - 381   2024.4   ISSN:0941-1291

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    Language:English   Publisher:シュプリンガー・ジャパン(株)  

    手術室と遠隔地にそれぞれ触覚フィードバック付きの術者用コンソールを設置し、遠隔手術における触覚フィードバックの有用性を検証し、さらに遠隔ロボット手術の安全性向上を目的として、動物実験を行った。術者用コンソールは福岡市と別府市の手術室に設置し、3段階の触覚フィードバックレベルをランダム順に設定した。術者(現地5名、遠隔地5名)を盲検化し、各触覚レベルでロボット鉗子によりブタの腸を把持する、持ち上げる、下げる、離すという一連の動作を10回繰り返してもらった。その結果、課題の精度や平均把持力には、術者の場所による顕著な差は見られなかった。しかし、遠隔地の場合は現地よりも平均課題完了時間が有意に長く、system usability scaleが有意に低かった。触覚フィードバックレベル間で、課題の精度や課題完了時間に顕著な差はなかったが、触覚フィードバックがある場合はない場合よりも有意に弱い力で臓器を把持することができた。さらに、触覚フィードバックがある場合、ロボット手術の経験が豊富な外科医は、経験の浅い外科医よりも弱い把持力で同等のタスクを行う傾向があった。

  • A prospective multicenter phase II trial of total neoadjuvant therapy for locally advanced rectal cancer in JAPAN: ENSEMBLE-1 study.

    Kagawa, Y; Watanabe, J; Ando, K; Uemura, M; Inoue, A; Oba, K; Takemasa, I; Oki, E

    JOURNAL OF CLINICAL ONCOLOGY   42 ( 3_SUPPL )   123 - 123   2024.1   ISSN:0732-183X eISSN:1527-7755

  • Circulating tumor DNA (ctDNA) dynamics in patients with colorectal cancer (CRC) with molecular residual disease: Updated analysis from GALAXY study in the CIRCULATE-JAPAN.

    Yukami, H; Nakamura, Y; Mishima, S; Ando, K; Bando, H; Watanabe, J; Hirata, K; Akazawa, N; Ikeda, M; Yokota, M; Kato, K; Laliotis, G; Aushev, VN; Jurdi, AA; Liu, M; Kotani, D; Oki, E; Takemasa, I; Kato, T; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   42 ( 3_SUPPL )   6 - 6   2024.1   ISSN:0732-183X eISSN:1527-7755

  • Association of circulating tumor DNA (ctDNA) molecular disease (MRD) detection with lymph node metastasis after local excision of pathological T1 colorectal cancer: First results from DENEB, a CIRCULATE-Japan GALAXY substudy

    Miyo, M; Kato, T; Nakamura, Y; Mishima, S; Bando, H; Yukami, H; Ando, K; Watanabe, J; Akazawa, N; Yokota, M; Kagawa, Y; Jurdi, AA; Liu, MC; Oba, K; Taniguchi, H; Kotani, D; Oki, E; Takemasa, I; Mori, M; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   42 ( 3_SUPPL )   23 - 23   2024.1   ISSN:0732-183X eISSN:1527-7755

  • Ⅳ. Prospects for Total Neoadjuvant Therapy for Patients with MSS Locally Advanced Rectal Cancer

    Kagawa Y., Ando K., Watanabe J.

    Gan to kagaku ryoho. Cancer &amp; chemotherapy   50 ( 11 )   1182 - 1184   2023.11   ISSN:03850684

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  • Short-term outcomes of a prospective multicenter phase II trial of total neoadjuvant therapy for locally advanced rectal cancer in Japan (ENSEMBLE-1)

    Kagawa, Y; Watanabe, J; Uemura, M; Ando, K; Inoue, A; Oba, K; Takemasa, I; Oki, E

    ANNALS OF GASTROENTEROLOGICAL SURGERY   7 ( 6 )   968 - 976   2023.11   ISSN:2475-0328

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    Language:English   Publisher:Annals of Gastroenterological Surgery  

    Aim: To evaluate the feasibility and safety of total neoadjuvant therapy (TNT) in patients with locally advanced rectal cancer (LARC) in Japan. Methods: This prospective, multicenter, open-label, single-arm phase II trial was conducted at five institutions. The key eligibility criteria were age ≥ 20 years, LARC within 12 cm from the anal verge, and cT3-4N0M0 or TanyN+M0 at the time of diagnosis that enabled curative resection. Preoperative short-course radiation therapy (SCRT) 5 Gy × 5 days (total 25 Gy) + CAPOX (six courses) followed by total mesorectum excision (TME) was the treatment protocol. Non-operative management (NOM) was allowed if clinical complete response (cCR) was obtained in the preoperative evaluation. The primary endpoint was the pathological complete response (pCR) rate. Results: Thirty patients (male, n = 26; female, n = 4; median age, 62.5 [44–74] years; cT [T2, n = 1; T3, n = 25; T4, n = 4]; cN [N0, n = 13; N1, n = 13; N2, n = 4]) were enrolled. The final analysis included 30 patients in total. The completion rates were 100% for SCRT and 83% for CAPOX. TME and NOM were performed in 20 and seven patients, respectively. pCR was observed in six patients (30% [95% CI 14.0%–50.8%]). The primary endpoint was met. pCR+cCR was observed in 13 (43.3%) patients. There were no treatment-related deaths. Grade ≥3 (CTCAE ver. 5.0) adverse events (≥20%), including diarrhea (23.3%) and neutropenia (23.3%). The median follow-up period was 15.6 (10.5–22.8) months, with no recurrence or regrowth in NOM. Conclusions: ENSEMBLE-1 demonstrated satisfactory pCR and cCR, and well-tolerated safety of TNT for patients with LARC in Japan.

    DOI: 10.1002/ags3.12715

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  • 日本における局所進行直腸癌に対するtotal neoadjuvant therapyの前向き多施設第2相研究の短期成績(ENSEMBLE-1)(Short-term outcomes of a prospective multicenter phase II trial of total neoadjuvant therapy for locally advanced rectal cancer in Japan(ENSEMBLE-1))

    Kagawa Yoshinori, Watanabe Jun, Uemura Mamoru, Ando Koji, Inoue Akira, Oba Koji, Takemasa Ichiro, Oki Eiji

    Annals of Gastroenterological Surgery   7 ( 6 )   968 - 976   2023.11

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    Language:English   Publisher:John Wiley & Sons Australia, Ltd  

    本研究の目的は、日本における、局所進行直腸癌(LARC)に対するtotal neoadjuvant therapy(TNT)の妥当性と安全性を評価することである。本研究は、5施設で施行された前向き多施設オープンラベル、シングルアーム第2相試験である。主たる適格基準は、年齢20歳以上、肛門縁から12cm以内のLARC、診断時にcT3-4N0M0またはTanyN+M0で、治癒切除可能であることとした。術前短期間放射線照射(SRCT)5Gy×5日(合計25Gy)+CAPOX(6コース)施行後に、全直腸間膜切除(TME)を施行するプロトコールとした。手術前の評価で臨床的に完全緩解(cCR)と診断された場合、非手術療法(NOM)を許容した。主要観察項目は病理学的完全緩解(pCR)率とした。30症例が登録された(男性、n=26、女性、n=4、年齢中央値、62.5(44~74)歳、cT(T2、n=1、T3、n=25、T4、n=4)、cN(N0、n=13、N1、n=13、N2、n=4))。30例全例が最終解析対象となった。SCRT完遂率は100%、CAPOX完遂率は83%であった。TME施行例が20例、NOMとなった症例が7例であった。pCRが得られた症例は6例(30%、95%CI 14.0%-50.8%)で、主要観察項目に合致した。pCR+cCRは13例(43.3%)で認められた。治療関連死はなかった。グレード3以上(CTCAE第5版)の有害事象が20%以上で認められ、下痢が23.3%、好中球減少症が23.3%であった。経過観察期間の中央値は15.6(10.5~22.8)ヵ月で、NOM症例に再発、再増殖は認められなかった。

  • Mutational spectrum of <i>TP53</i> gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study)

    Ando, K; Nakamura, Y; Kitao, H; Shimokawa, M; Kotani, D; Bando, H; Nishina, T; Yamada, T; Yuki, S; Narita, Y; Hara, H; Ohta, T; Esaki, T; Hamamoto, Y; Kato, K; Yamamoto, Y; Minashi, K; Ohtsubo, K; Izawa, N; Kawakami, H; Kato, T; Satoh, T; Okano, N; Tsuji, A; Yamazaki, K; Yoshino, T; Maehara, Y; Oki, E

    BRITISH JOURNAL OF CANCER   129 ( 6 )   1032 - 1039   2023.10   ISSN:0007-0920 eISSN:1532-1827

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    Background: Although nivolumab has a high efficacy, reliable biomarkers are needed to predict the efficacy. We evaluated the nivolumab efficacy according to the TP53 mutation in advanced gastric cancer patients enrolled in the GI-SCREEN project. Methods: Sequence data of tumour specimens and clinicopathological information of 913 patients with advanced gastric cancer who were enrolled between April 2015 and March 2017 were obtained from the GI-SCREEN database. The follow-up information of 266 patients treated with nivolumab was also provided. Results: Among 266 patients treated with nivolumab, the objective response rate (ORR) of TP53 wild type (wt) patients (24.6%) was higher than that of TP53 mutant patients (14.8%). Among TP53 mutant patients, the ORR of the frameshift type tended to be higher than the transition and transversion type (23.1%, 13.6%, and 13.0%, respectively). The median progression-free survival (PFS) was statistically longer in TP53 wt patients than in mutant patients (3.3 vs 2.1 months, HR 1.4, 95% CI 1.1–1.9). Among TP53 mutant patients, PFS was statistically longer in the frameshift type than in the transversion type. Conclusion: Nivolumab showed better efficacy in TP53 wt patients than in mutant patients. Among TP53 mutant patients, the frameshift type may have efficacy from nivolumab treatment.

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  • The impacts of starting regorafenib dose on treatment outcomes in metastatic colorectal cancer

    Yuki, S; Harada, K; Kawakami, T; Ogata, T; Hu, Q; Fushiki, K; Oshima, K; Kadowaki, S; Taniguchi, H; Muro, K; Nakanishi, R; Ando, K; Nambara, S; Nakamura, T; Kawamoto, Y; Komatsu, Y; Oki, E; Masuishi, T; Yamazaki, K

    ANNALS OF ONCOLOGY   34   S441 - S442   2023.10   ISSN:0923-7534 eISSN:1569-8041

  • A prospective study of FOLFIRI plus aflibercept as second-line treatment after failure of FOLFOXIRI plus bevacizumab in patients with unresectable/metastatic colorectal cancer (CRC): EFFORT study

    Satake, H; Ando, K; Yasui, H; Negoro, Y; Kinjo, T; Yuge, K; Baba, K; Orita, H; Hirata, K; Shimokawa, M; Makiyama, A; Saeki, H; Oki, E; Baba, H

    JOURNAL OF CLINICAL ONCOLOGY   41 ( 16 )   2023.6   ISSN:0732-183X eISSN:1527-7755

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  • Circulating tumor DNA dynamics as an early predictor of recurrence in patients with radically resected colorectal cancer: Updated results from GALAXY study in the CIRCULATE-Japan.

    Oki, E; Kotani, D; Nakamura, Y; Mishima, S; Bando, H; Yukami, H; Ando, K; Miyo, M; Watanabe, J; Hirata, K; Akazawa, N; Yeh, KH; Laliotis, G; Sharma, S; Liu, M; Taniguchi, H; Takemasa, I; Kato, T; Mori, M; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   41 ( 16 )   2023.6   ISSN:0732-183X eISSN:1527-7755

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  • Mutational spectrum of TP53 gene correlates with nivolumab treatment efficacy in advanced gastric cancer (TP53MUT study). Invited Reviewed International journal

    Ando K, Nakamura Y, Kitao H, Shimokawa M, Kotani D, Bando H, Nishina T, Yamada T, Yuki S, Narita Y, Hara H, Ohta T, Esaki T, Hamamoto Y, Kato K, Yamamoto Y, Minashi K, Ohtsubo K, Izawa N, Kawakami H, Kato T, Satoh T, Okano N, Tsuji A, Yamazaki K, Yoshino T, Maehara Y, Oki E.

    Br J Cancer   2023.6

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  • Artificial Intelligence-Based Prediction of Recurrence After Curative Resection for Colorectal Cancer From a Digital Pathologic Image

    Nakanishi, R; Morooka, K; Omori, K; Toyota, S; Tanaka, Y; Hasuda, H; Koga, N; Nonaka, K; Hu, QJ; Nakaji, Y; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Oki, E; Oda, Y; Yoshizumi, T

    ANNALS OF SURGICAL ONCOLOGY   30 ( 6 )   3515 - 3516   2023.6   ISSN:1068-9265 eISSN:1534-4681

  • Telesurgery and telesurgical support using a double-surgeon cockpit system allowing manipulation from two locations

    Oki, E; Ota, M; Nakanoko, T; Tanaka, Y; Toyota, S; Hu, QJ; Nakaji, Y; Nakanishi, R; Ando, K; Kimura, Y; Hisamatsu, Y; Mimori, K; Takahashi, Y; Morohashi, H; Kanno, T; Tadano, K; Kawashima, K; Takano, H; Ebihara, Y; Shiota, M; Inokuchi, J; Eto, M; Yoshizumi, T; Hakamada, K; Hirano, S; Mori, M

    SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES   37 ( 8 )   6071 - 6078   2023.5   ISSN:0930-2794 eISSN:1432-2218

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    Background: Although several studies on telesurgery have been reported globally, a clinically applicable technique has not yet been developed. As part of a telesurgical study series conducted by the Japan Surgical Society, this study describes the first application of a double-surgeon cockpit system to telesurgery. Methods: Surgeon cockpits were installed at a local site and a remote site 140 km away. Three healthy pigs weighing between 26 and 29 kg were selected for surgery. Non-specialized surgeons performed emergency hemostasis, cholecystectomy, and renal vein ligation with remote assistance using the double-surgeon cockpits and specialized surgeons performed actual telesurgery. Additionally, the impact of adding internet protocol security (IPsec) encryption to the internet protocol-virtual private network (IP-VPN) line on communication was evaluated to address clinical security concerns. Results: The average time required for remote emergency hemostasis with the double-surgeon cockpit system was 10.64 s. A non-specialized surgeon could safely perform cholecystectomy or renal vein ligation with remote assistance. Global Evaluative Assessment of Robotic Skills and System Usability Scale scores were higher for telesurgical support-assisted surgery by a non-specialized surgeon using the double-surgeon cockpits than for telesurgery performed by a specialized surgeon without the double-cockpit system. Adding IPsec encryption to the IP-VPN did not have a significant impact on communication. Conclusion: Telesurgical support through our double-surgeon cockpit system is feasible as first step toward clinical telesurgery.

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  • Lineage of drug discovery research on fluorinated pyrimidines: chronicle of the achievements accomplished by Professor Setsuro Fujii

    Maehara, Y; Oki, E; Ota, M; Harimoto, N; Ando, K; Nakanishi, R; Kawazoe, T; Fujimoto, Y; Nonaka, K; Kitao, H; Iimori, M; Makino, K; Takechi, T; Sagara, T; Miyadera, K; Matsuoka, K; Tsukihara, H; Kataoka, Y; Wakasa, T; Ochiiwa, H; Kamahori, Y; Tokunaga, E; Saeki, H; Yoshizumi, T; Kakeji, Y; Shirabe, K; Baba, H; Shimada, M

    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY   28 ( 5 )   613 - 624   2023.5   ISSN:1341-9625 eISSN:1437-7772

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    Prof. Setsuro Fujii achieved significant results in the field of drug discovery research in Japan. He developed nine well-known drugs: FT, UFT, S-1 and FTD/TPI are anticancer drugs, while cetraxate hydrochloride, camostat mesilate, nafamostat mesilate, gabexate mesilate and pravastatin sodium are therapeutic drugs for various other diseases. He delivered hope to patients with various diseases across the world to improve their condition. Even now, drug discovery research based on Dr. Fujii’s ideas is continuing.

    DOI: 10.1007/s10147-023-02326-w

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  • TaTMEの効果的な応用により肛門温存できた肛門近傍巨大直腸GISTの1例

    岩井 周作, 北口 大地, 野田 朋宏, 安藤 幸滋, 塚田 祐一郎, 伊藤 雅昭

    手術   77 ( 5 )   621 - 627   2023.5   ISSN:0037-4423

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    症例は60代男性で、肛門部のしこりを主訴とした。生検で直腸GISTと診断され、6ヵ月間の術前補助化学療法後の術前MRIでは、肛門管の左側~左坐骨直腸窩の脂肪織内に長径66mm大の境界明瞭な腫瘤性病変を認め、肛門管近傍の下部直腸から肛門挙筋を圧排し坐骨直腸窩へ伸展していた。手術はTaTMEの技術を応用し腹腔鏡下操作に加え、経肛門的かつ経臀部的な内視鏡操作を併用し、経臀部的な剥離に先立ち肛門管内腔側から腫瘍下縁と直腸壁との境界を認識し、腸管外側から内視鏡下にアプローチした。腫瘍部では内・外肛門括約筋と肛門挙筋を合併切除する際に腫瘍対側の切離ラインをやや口側に設定し、肛門括約筋の最大限の温存を試みた。合併症なく術後14日目に退院し、術後補助化学療法としてイマチニブ内服を開始した。術後4ヵ月半で回腸人工肛門閉鎖術を施行し、再手術後3ヵ月経過して肛門機能障害は軽微で通常通りの日常生活が可能となり、術後10ヵ月間無再発で経過している。

  • Ensemble study: A multicenter, randomized, phase III trial to test the superiority of consolidation irinotecan, capecitabine and oxaliplatin vs capecitabine and oxaliplatin following short course radiotherapy as total neoadjuvant therapy in patients with locally advanced rectal cancer.

    Watanabe, J; Kagawa, Y; Kotani, D; Ando, K; Chida, K; Oba, K; Bando, H; Hojo, H; Shimamoto, S; Sakashita, S; Kuwata, T; Tsuboyama, T; Uemura, M; Uehara, K; Ito, M; Oki, E; Takemasa, I; Misugi, E; Kato, T; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   41   TPS276 - TPS276   2023.2   ISSN:0732-183X eISSN:1527-7755

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  • The impacts of initiating regorafenib with reduced dose on treatment outcomes in metastatic colorectal cancer.

    Kawakami, T; Harada, K; Ogata, T; Hu, QJ; Fushiki, K; Oshima, K; Kadowaki, S; Taniguchi, H; Muro, K; Nakanishi, R; Ando, K; Nambara, S; Yamamura, T; Kawamoto, Y; Komatsu, Y; Oki, E; Masuishi, T; Yamazaki, K; Yuki, S

    JOURNAL OF CLINICAL ONCOLOGY   41   133 - 133   2023.2   ISSN:0732-183X eISSN:1527-7755

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  • Artificial Intelligence-Based Prediction of Recurrence after Curative Resection for Colorectal Cancer from Digital Pathological Images

    Nakanishi, R; Morooka, K; Omori, K; Toyota, S; Tanaka, Y; Hasuda, H; Koga, N; Nonaka, K; Hu, QJ; Nakaji, Y; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Oki, E; Oda, Y; Yoshizumi, T

    ANNALS OF SURGICAL ONCOLOGY   30 ( 6 )   3506 - 3514   2022.12   ISSN:1068-9265 eISSN:1534-4681

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    Background: To develop an artificial intelligence-based model to predict recurrence after curative resection for stage I–III colorectal cancer from digitized pathological slides. Patients and Methods: In this retrospective study, 471 consecutive patients who underwent curative resection for stage I–III colorectal cancer at our institution from 2004 to 2015 were enrolled, and 512 randomly selected tiles from digitally scanned images of hematoxylin and eosin-stained tumor tissue sections were used to train a convolutional neural network. Five-fold cross-validation was used to validate the model. The association between recurrence and the model’s output scores were analyzed in the test cohorts. Results: The area under the receiver operating characteristic curve of the cross-validation was 0.7245 [95% confidence interval (CI) 0.6707–0.7783; P < 0.0001]. The score successfully classified patients into those with better and worse recurrence free survival (P < 0.0001). Multivariate analysis revealed that a high score was significantly associated with worse recurrence free survival [odds ratio (OR) 1.857; 95% CI 1.248–2.805; P = 0.0021], which was independent from other predictive factors: male sex (P = 0.0238), rectal cancer (P = 0.0396), preoperative abnormal carcinoembryonic antigen (CEA) level (P = 0.0216), pathological T3/T4 stage (P = 0.0162), and pathological positive lymph node metastasis (P < 0.0001). Conclusions: The artificial intelligence-based prediction model discriminated patients with a high risk of recurrence. This approach could help decision-makers consider the benefits of adjuvant chemotherapy.

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  • <i>NOTCH</i> gene alterations in metastatic colorectal cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN)

    Kajiwara, T; Nishina, T; Nakasya, A; Yamashita, N; Yamashita, R; Nakamura, Y; Shiozawa, M; Yuki, S; Taniguchi, H; Hara, H; Ohta, T; Esaki, T; Shinozaki, E; Takashima, A; Moriwaki, T; Denda, T; Ohtsubo, K; Sunakawa, Y; Horita, Y; Kawakami, H; Kato, T; Satoh, T; Ando, K; Mizutani, T; Yasui, H; Goto, M; Okuyama, H; Yamazaki, K; Yoshino, T; Hyodo, I

    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY   148 ( 10 )   2841 - 2854   2022.10   ISSN:0171-5216 eISSN:1432-1335

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    Purpose: Activated Notch receptor signaling has been implicated in tumor growth and progression in colorectal cancer (CRC). However, the pathogenic relevance of NOTCH gene alterations remains unclear. The aim of this study was to clarify mutational landscapes and assess their clinical significance in patients with metastatic CRC. Methods: Pre-chemotherapy tumor tissues obtained from 1154 metastatic CRC patients in the Nationwide Cancer Genome Screening Project in Japan between April 2017 and March 2019 were studied using the Oncomine Comprehensive Assay. Results: The frequencies of NOTCH1, NOTCH2, and NOTCH3 nonsynonymous sequence variants were 11.5%, 4.4%, and 10.4%, respectively. The majority of variants were missense of unknown significance that were distributed across all domains of all three NOTCH genes. The gain-of-function mutations in NOTCH reported in multiple malignancies were not identified. The NOTCH amplification rate was less than 1%. No NOTCH fusions were detected. In patients who were registered before, or within 1 year of, first-line chemotherapy, overall survival for 51 patients with only NOTCH3 variants was significantly longer than for 540 patients with no NOTCH variants (median, 40.2 months vs 27.7 months; P = 0.04). Multivariate analysis revealed that variant NOTCH3 was an independent prognostic factor for increased survival (hazard ratio 0.61, 95% confidence interval, 0.39–0.94; P = 0.03) besides poor prognostic factors associated with mutant TP53, KRAS, and BRAF, as well as amplified MYC. Conclusion: NOTCH genes are unlikely to harbor driver mutations and amplifications in patients with metastatic CRC. NOTCH3 variant should be further investigated as a favorable prognostic marker.

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  • Influence of Robotic Rectal Resection Versus Laparoscopic Rectal Resection on Postoperative Ileus: A Single-center Experience

    Hu, QJ; Oki, E; Fujimoto, Y; Jogo, T; Hokonohara, K; Nakanishi, R; Hisamatsu, Y; Ando, K; Kimura, Y; Mori, M

    SURGICAL LAPAROSCOPY ENDOSCOPY & PERCUTANEOUS TECHNIQUES   32 ( 4 )   425 - 430   2022.8   ISSN:1530-4515 eISSN:1534-4908

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    Aim: This study was performed to clarify the relationship between robotic rectal resection and postoperative ileus (POI) by comparing robotic surgery with laparoscopic surgery. Materials and Methods: We retrospectively reviewed 238 patients who underwent robotic (n=41) or laparoscopic (n=197) rectal resection for rectal cancer in our institution from January 2013 to June 2020. First, we compared the background factors and short-term surgical outcomes between robotic and laparoscopic surgery. Next, we investigated the postoperative complications of robotic and laparoscopic rectal resection. Finally, we identified the risk factors for POI following rectal cancer resection. Results: The percentages of patients with an Rb tumor location, treatment by abdominoperitoneal resection/intersphincteric resection/low anterior resection, a temporary diverting ileostomy, and a long operation time were significantly higher in robotic than laparoscopic surgery (P<0.0001, P=0.0002, P=0.0078, and P=0.0001, respectively). There was no significant difference in any individual postoperative complication between robotic and laparoscopic surgery. Risk factors for POI were male sex (P=0.0078), neoadjuvant chemoradiotherapy (P=0.0007), an Rb tumor location (P=0.0005), treatment by abdominoperitoneal resection/intersphincteric resection/low anterior resection (P=0.0044), a temporary diverting ileostomy (P<0.0001), and operation time of ≥240 minutes (P=0.0024). Notably, robotic surgery was not a risk factor for POI following rectal resection relative to laparoscopic surgery. Conclusion: Although patients who underwent robotic surgery had more risk factors for POI, the risk of POI was similar between robotic and laparoscopic rectal resection.

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  • FOLFOXIRI plus cetuximab versus bevacizumab in RAS wild-type mCRC: the subgroup-analysis of DEEPER trial (JACCRO CC-13)

    Yabuno, T; Tsuji, A; Tokunaga, T; Yuki, S; Kudo, T; Mashita, N; Ando, K; Takeuchi, N; Kashiwada, T; Kataoka, M; Kochi, M; Sagawa, T; Kotaka, M; Kubota, Y; Sunakawa, Y; Sekikawa, T; Nakamura, M; Takeuchi, M; Ichikawa, W; Fujii, M

    ANNALS OF ONCOLOGY   33   S471 - S471   2022.7   ISSN:0923-7534 eISSN:1569-8041

  • Plasma <i>RAS</i> dynamics and anti-EGFR rechallenge efficacy in patients with <i>RAS</i>/<i>BRAF</i> wild-type metastatic colorectal cancer: REMARRY and PURSUIT trials.

    Kagawa, Y; Kotani, D; Bando, H; Takahashi, N; Hamaguchi, T; Kanazawa, A; Kato, T; Ando, K; Satake, H; Shinozaki, E; Sunakawa, Y; Takashima, A; Yamazaki, K; Yuki, S; Nakajima, H; Nakamura, Y; Wakabayashi, M; Taniguchi, H; Ohta, T; Yoshino, T

    JOURNAL OF CLINICAL ONCOLOGY   40 ( 16 )   2022.6   ISSN:0732-183X eISSN:1527-7755

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  • Plasma RAS dynamics and efficacy of anti-EGFR rechallenge in patients with RAS/BRAF wild-type metastatic colorectal cancer: REMARRY and PURSUIT trials

    Kagawa, Y; Kotani, D; Bando, H; Takahashi, N; Horita, Y; Kanazawa, A; Kato, T; Ando, K; Satake, H; Shinozaki, E; Sunakawa, Y; Takashima, A; Yamazaki, K; Yuki, S; Nakajima, H; Nakamura, Y; Wakabayashi, M; Taniguchi, H; Ohta, T; Yoshino, T

    ANNALS OF ONCOLOGY   33   S244 - S244   2022.6   ISSN:0923-7534 eISSN:1569-8041

  • Dynamics of Circulating Tumor DNA After Resection of Colorectal Cancer : GALAXY Study in Circulate-japan

    Oki, E; Shirasu, H; Watanabe, J; Yamazaki, K; Hirata, K; Akazawa, N; Ikeda, M; Kotaka, M; Kato, K; Kinoshita, T; Yokota, M; Shiozawa, M; Yoshida, K; Noura, S; Ikenaga, M; Yamaguchi, T; Aleshin, A; Sharma, S; Ando, K; Kotani, D; Takemasa, I; Kato, T; Nakamura, Y; Taniguchi, H; Yoshino, T; Mori, M

    ANNALS OF SURGICAL ONCOLOGY   29 ( SUPPL 2 )   343 - 343   2022.5   ISSN:1068-9265 eISSN:1534-4681

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  • Intraoperative Quantitative Imaging of Tissue O2 Metabolism by Near-Infrared Spectroscopy for Reconstruction after Esophagectomy

    Kimura Y., Haruta Y., Hu Q., Nakaji Y., Nakanishi R., Nakanoko T., Ando K., Ohta M., Oki E., Ikeda T., Yoshizumi T.

    Nihon Kikan Shokudoka Gakkai Kaiho   73 ( 2 )   185 - 186   2022.4   ISSN:00290645 eISSN:18806848

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  • DENEB: Development of new criteria for curability after local excision of pathological T1 colorectal cancer using liquid biopsy

    Miyo, M; Kato, T; Nakamura, Y; Taniguchi, H; Takahashi, Y; Ishii, M; Okita, K; Ando, K; Yukami, H; Mishima, S; Yamazaki, K; Kotaka, M; Watanabe, J; Oba, K; Aleshin, A; Billings, PR; Rabinowitz, M; Kotani, D; Oki, E; Takemasa, I; Mori, M; Yoshino, T

    CANCER SCIENCE   113 ( 4 )   1531 - 1534   2022.4   ISSN:1347-9032 eISSN:1349-7006

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    According to the current international guidelines, high-risk patients diagnosed with pathological T1 (pT1) colorectal cancer (CRC) who underwent complete local resection but may have risk of developing lymph node metastasis (LNM) are recommended additional intestinal resection with lymph node dissection. However, around 90% of the patients without LNM are exposed to the risk of being overtreated due to the insufficient pathological criteria for risk stratification of LNM. Circulating tumor DNA (ctDNA) is a noninvasive biomarker for molecular residual disease and relapse detection after treatments including surgical and endoscopic resection of solid tumors. The CIRCULATE-Japan project includes a large-scale patient-screening registry of the GALAXY study to track ctDNA status of patients with stage II to IV or recurrent CRC that can be completely resected. Based on the CIRCULATE-Japan platform, we launched DENEB, a new prospective study, within the GALAXY study for patients with pT1 CRC who underwent complete local resection and were scheduled for additional intestinal resection with lymph node dissection based on the standard pathologic risk stratification criteria for LNM. The aim of this study is to explore the ability of predicting LNM using ctDNA analysis compared with the standard pathological criteria. The ctDNA assay will build new evidence to establish a noninvasive personalized diagnosis in patients, which will facilitate tailored/optimal treatment strategies for CRC patients.

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  • DENEB リキッドバイオプシーを用いた病理学的T1大腸癌の局所切除後の治癒に対する新基準の開発(DENEB: Development of new criteria for curability after local excision of pathological T1 colorectal cancer using liquid biopsy)

    Miyo Masaaki, Kato Takeshi, Nakamura Yoshiaki, Taniguchi Hiroya, Takahashi Yusuke, Ishii Masayuki, Okita Kenji, Ando Koji, Yukami Hiroki, Mishima Saori, Yamazaki Kentaro, Kotaka Masahito, Watanabe Jun, Oba Koji, Aleshin Alexey, Billings Paul R., Rabinowitz Matthew, Kotani Daisuke, Oki Eiji, Takemasa Ichiro, Mori Masaki, Yoshino Takayuki

    Cancer Science   113 ( 4 )   1531 - 1534   2022.4   ISSN:1347-9032

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    リキッドバイオプシーによる癌個別化医療の実現を目指すプロジェクト「CIRCULATE-Japan」は、観察研究(GALAXY試験)と2つの無作為化第III相試験(VEGA試験およびALTAIR試験)で構成されている。GALAXY試験では完全切除が可能なステージIIからIVまたは再発大腸癌患者の血中循環腫瘍DNA(ctDNA)状態を追跡している。著者らは、CIRCULATE-Japanのプラットフォームに基づき、GALAXY試験内で、局所完全切除を受けたpT1大腸癌患者のうち、リンパ節転移に関する標準的な病理学的リスク層別化基準に基づいてリンパ節郭清を伴う腸管追加切除が予定されている患者を対象に、新しい前向き研究であるDENEBを開始した。本研究の目的は、標準的な病理学的基準と比較して、ctDNA分析を用いたリンパ節転移の予測能力を探ることである。ctDNAアッセイは、大腸癌患者における非侵襲的な個別化診断を確立するための新たなエビデンスを構築し、大腸癌患者の個別化医療や最適な治療戦略を促進することが期待される。

  • Clinical impact of the triple-layered circular stapler for reducing the anastomotic leakage in rectal cancer surgery: Porcine model and multicenter retrospective cohort analysis

    Nakanishi, R; Fujimoto, Y; Sugiyama, M; Hisamatsu, Y; Nakanoko, T; Ando, K; Ota, M; Kimura, Y; Oki, E; Yoshizumi, T

    ANNALS OF GASTROENTEROLOGICAL SURGERY   6 ( 2 )   256 - 264   2022.3   ISSN:2475-0328

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    Aim: To investigate the impact of the triple-layered circular stapler compared with the double-layered circular stapler on anastomotic leakage after rectal cancer surgery. Methods: The bursting pressure was compared between porcine ileocolic anastomoses created using a double- or triple-layered stapler. We also retrospectively analyzed the incidence of severe anastomotic leakage in 194 patients who underwent colorectal anastomosis using a double- or triple-layered circular stapler during rectal cancer resection performed in two cancer centers between January 2015 and April 2021. Results: In the porcine model, the bursting pressure was higher in anastomoses created using the triple-layered stapler than the double-layered stapler (end-to-end anastomosis: 26.4 ± 6.2 mm Hg vs 14.5 ± 4.3 mm Hg, P =.0031; side-to-side anastomosis: 27.7 ± 5.0 mm Hg vs 18.0 ± 2.9 mm Hg, P =.0275). Intersectional leakage occurred in 41% and 83% of anastomoses created using the triple- or double-layered stapler, respectively (P =.0821). In the clinical cohort, the double- and triple-layered stapler was used in 153 and 41 patients, respectively. The incidence of anastomotic leakage was lower for anastomoses created using the triple-layered stapler vs the double-layered stapler (0.0% vs 5.8%, P =.0362). In multivariate analysis, the factors independently associated with a lower incidence of anastomotic leakage were female sex (odds ratio: 0.16, 95% confidence interval: 0.01-0.90, P =.0354) and triple-layered stapler usage (odds ratio: 0.00, 95% confidence interval: 0.00-0.96, P =.0465). Conclusion: Anastomoses created using a triple-layered circular stapler had high bursting pressure, which might contribute to a lower incidence of anastomotic leakage after rectal cancer surgery.

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  • 直腸癌手術において三層サーキュラーステープラーが吻合部漏の減少に及ぼす臨床的影響 ブタモデルと多施設後ろ向きコホート解析(Clinical impact of the triple-layered circular stapler for reducing the anastomotic leakage in rectal cancer surgery: Porcine model and multicenter retrospective cohort analysis)

    Nakanishi Ryota, Fujimoto Yoshiaki, Sugiyama Masahiko, Hisamatsu Yuichi, Nakanoko Tomonori, Ando Koji, Ota Mitsuhiko, Kimura Yasue, Oki Eiji, Yoshizumi Tomoharu

    Annals of Gastroenterological Surgery   6 ( 2 )   256 - 264   2022.3

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    直腸癌手術後に生じる吻合部漏に対する三層サーキュラーステープラーと二層サーキュラーステープラーの有効性を比較検討した。ブタ回結腸吻合部における三層サーキュラーステープラーと二層サーキュラーステープラーの破裂圧を比較した。さらに、直腸癌に対して大腸吻合術を施行された194例を対象とする多施設後ろ向きコホート研究を実施して重度吻合部漏の術後発症率を評価した。二層サーキュラーステープラー使用群(EEA群)が153例(男性84例、女性69例、中央値66歳)、三層サーキュラーステープラー使用群(tri-EEA群)が41例(男性23例、女性18例、中央値67歳)であった。ブタを用いた実験での破裂圧は三層サーキュラーステープラーが26.4±6.2mmHg、二層サーキュラーステープラーが14.5±4.3mmHgと三層の方が有意に高値を示していた。臨床研究ではtri-EEA群の方がEEA群と比較して手術時間は有意に長く、術後在院期間と術後合併症の発症率に関してtri-EEA群とEEA群との間に有意差はみられなかったが、グレード3以上の吻合部漏の発症率はtri-EEA群の方が有意に低かった(0.0% vs 5.8%)。多変量解析ではtri-EEAの施行が吻合部漏の非発症を示す独立関連因子として抽出された。

  • Plasma-informed minimal residual disease (MRD) assay: A multicenter prospective study in Japanese patients with stage II colorectal cancer

    Oki, E; Ando, K; Hisamatsu, Y; Nakanishi, R; Nakaji, Y; Kudou, K; Kusumoto, T; Kagawa, Y; Ung, WC; Niiro, H; Tada, S; Hirose, T

    JOURNAL OF CLINICAL ONCOLOGY   40 ( 4 )   2022.2   ISSN:0732-183X eISSN:1527-7755

  • Discovering the mechanism of cellular resistance to irinotecan and finding a predictive biomarker

    Ando, K; Hasuda, H; Matsuoka, H; Hu, QJ; Bharti, A; Oki, E

    CANCER SCIENCE   113   1416 - 1416   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • Monitoring FTD in the PBMCs of elderly patients with mCRC administered FTD plus bevacizumab

    Fujimoto, Y; Nakanishi, R; Ando, K; Makiyama, A; Miyamoto, Y; Kotaka, M; Shimokawa, M; Kitao, H; Oki, E; Uehara, H; Sugiyama, M; Nakashima, Y; Yamamoto, M; Morita, M; Toh, Y

    CANCER SCIENCE   113   757 - 757   2022.2   ISSN:1347-9032 eISSN:1349-7006

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  • Sustainable Clinical Development of Adjuvant Chemotherapy for Colon Cancer

    Oki, E; Ando, K; Taniguchi, H; Yoshino, T; Mori, M

    ANNALS OF GASTROENTEROLOGICAL SURGERY   6 ( 1 )   37 - 45   2022.1   ISSN:2475-0328

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    Numerous clinical studies in an adjuvant setting have been conducted and the combination therapy of 5-fluorouracil and oxaliplatin has been established as the standard treatment for Stage III and as an option for high-risk Stage II patients. Biologics such as bevacizumab and antiepidermal growth factor receptor antibodies have failed to show additional survival benefits. The indication of adjuvant chemotherapy has been determined according to the pathological stage. Nevertheless, a pathological diagnosis does not necessarily result in selection of the optimal treatment. To improve treatment decisions, many trials have aimed to stratify patients into treatment groups using genomic testing. Recently, gene signature, Immunoscore, and circulating tumor DNA (ctDNA) assays have been reported and among them, ctDNA was shown to be a promising accurate predictive marker for recurrence. Treatment of ctDNA-positive patients with aggressive chemotherapy may reduce recurrence rates. The ultimate goal is to accurately predict the risk of recurrence and to prevent recurrence in colon cancer patients. In this review we focus on the clinical development of adjuvant chemotherapy and stratification of patients according to risk of recurrence and the future direction of adjuvant chemotherapy.

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  • The effects of ARID1A mutations on colorectal cancer and associations with PD-L1 expression by stromal cells

    Kamori, T; Oki, E; Shimada, Y; Hu, QJ; Hisamatsu, Y; Ando, K; Shimokawa, M; Wakai, T; Oda, Y; Mori, M

    CANCER REPORTS   5 ( 1 )   e1420   2022.1   eISSN:2573-8348

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    Background: ARID1A is a component of the SWI/SNF complex, which controls the accessibility of proteins to DNA. ARID1A mutations are frequently observed in colorectal cancers (CRCs) and have been reported to be associated with high mutational burden and tumor PD-L1 expression in vitro. Aim: To clarify the role of ARID1A mutation in CRC. Method and results: We used next generation sequencing (NGS) and immunohistochemistry on clinically obtained samples. A total of 201 CRC tissues from Niigata University and Niigata Center Hospital were processed by NGS using the CANCERPLEX panel. Immunohistochemistry for ARID1A, PD-L1, MLH1, and MSH2 was performed on 66 propensity-matched (33 microsatellite instability-high [MSI-H] and 33 microsatellite-stable [MSS]) cases among 499 cases from Kyushu University. TCGA data were downloaded from cBioPortal. NGS showed significantly more mutations in ARID1A mutated CRCs (p = 0.01), and the trend was stronger for right-sided CRCs than left-sided. TCGA data confirmed these findings (p < 0.01). BRAF V600E and ATM mutations were also found at higher frequencies. Immunohistochemistry showed that 30% of MSI-H CRCs had ARID1A loss, while this was true in only 6% of MSS CRCs. In both MSI-H and MSS, PD-L1 expression by stromal cells was enhanced in the ARID1A-mutant groups (90% vs 39% in MSI-H, 100% vs 26% in MSS). Conclusion: We found a higher mutational burden in ARID1A-mutant CRCs, and IHC study showed that ARID1A loss was correlated with high PD-L1 expression in stromal cells regardless of MSI status. These data support the idea that mutant ARID1A is a potential biomarker for CRCs.

    DOI: 10.1002/cnr2.1420

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  • Recent developments in cancer research: Expectations for a new remedy. Invited Reviewed International journal

    Ando K, Hu Q, Kasagi Y, Oki E, Mori M.

    Ann Gastroenterol Surg   2021.11

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  • Multicohort Retrospective Validation of a Predictive Biomarker for Topoisomerase I Inhibitors. Invited Reviewed International journal

    Ando K, Ozonoff A, Lee SY, Voisine M, Parker JT, Nakanishi R, Nishimura S, Yang J, Grace Z, Tran B, Diefenbach TJ, Maehara Y, Yasui H, Irino T, Salgia R, Terashima M, Gibbs P, Ramanathan RK, Oki E, Mori M, Kulke M, Hartshorn K, Bharti A.

    Clin Colorectal Cancer.,   2021.4

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  • New anastomosis technique to prevent anastomotic leakage in laparoscopic anterior resection for rectal cancer, especially upper rectal cancer Invited Reviewed International journal

    Ando K, Kuriyama N, Fujimoto Y, Jogo T, Hokonohara K, Hu Q, Hisamatsu Y, Nakanishi R, Nakashima Y, Kimura Y, Oki E, Mori M.

    In Vivo   34 ( 6 )   3533 - 3538   2020.12

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    DOI: 10.21873/invivo.12195.

  • CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer. Invited Reviewed International journal

    Matsuoka H, Ando K, Swayze EJ, Unan EC, Mathew J, Hu Q, Tsuda Y, Nakashima Y, Saeki H, Oki E, Bharti AK, Mori M.

    PLoS One   2020.10

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  • Efficacy and feasibility of S-1 plus oxaliplatin (C-SOX) for treating patients with stage III colon cancer (KSCC1303): final analysis of 3-year disease-free survival Invited Reviewed International journal

    Ando K, Emi Y, Miyanari N, Tsuji A, Sakai K, Sawai T, Imamura H, Mori S, Tokunaga S, Oki E, Saeki H, Kakeji Y, Akagi Y, Baba H, Maehara Y, Mori M; Kyushu Study Group of Clinical Cancer (KSCC).

    Int J Clin Oncol   25 ( 6 )   1115 - 1122   2020.6

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    DOI: 10.1007/s10147-020-01646-5.

  • Skeletal Muscle Loss After Esophagectomy Is an Independent Risk Factor for Patients with Esophageal Cancer Reviewed

    Yuichiro Nakashima, Hiroshi Saeki, Qingjiang Hu, Yasuo Tsuda, Yoko Zaitsu, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Eiji Oki, Masaki Mori

    Annals of Surgical Oncology   27 ( 2 )   492 - 498   2020.2

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    DOI: 10.1245/s10434-019-07850-6

  • Changing the Dissectable Layer Novel Thoracoscopic Esophagectomy Method for Lymphadenectomy along the Left Recurrent Laryngeal Nerve Reviewed

    Yuichiro Nakashima, Hiroshi Saeki, Qingjiang Hu, Yasuo Tsuda, Yoko Zaitsu, Yuichi Hisamatsu, Koji Ando, Yasue Kimura, Eiji Oki, Masaki Mori

    Journal of the American College of Surgeons   230 ( 2 )   e1 - e6   2020.2

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    DOI: 10.1016/j.jamcollsurg.2019.10.013

  • The evolution of surgical treatment for gastrointestinal cancers Reviewed

    Yoshihiko Maehara, Yuji Soejima, Tomoharu Yoshizumi, Naoyuki Kawahara, Eiji Oki, Hiroshi Saeki, Tomohiko Akahoshi, Toru Ikegami, Yo ichi Yamashita, Tadashi Furuyama, Keishi Sugimachi, Noboru Harada, Tetsuzo Tagawa, Norifumi Harimoto, Shinji Itoh, Hideto Sonoda, Koji Ando, Yuichiro Nakashima, Yoshihiro Nagao, Nami Yamashita, Yuta Kasagi, Takafumi Yukaya, Takeshi Kurihara, Ryosuke Tsutsumi, Shinkichi Takamori, Shun Sasaki, Tetsuo Ikeda, Yoshikazu Yonemitsu, Takasuke Fukuhara, Hiroyuki Kitao, Makoto Iimori, Yuki Kataoka, Takeshi Wakasa, Masami Suzuki, Koji Teraishi, Yasuto Yoshida, Masaki Mori

    International Journal of Clinical Oncology   24 ( 11 )   1333 - 1349   2019.11

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    DOI: 10.1007/s10147-019-01499-7

  • Comparison of computed tomography imaging analyses for evaluation after chemotherapy in patients with colorectal cancer a retrospective pooled analysis of six phase II clinical trials Reviewed

    Kosuke Hirose, Eiji Oki, Takayuki Shimose, Sanae Sakamoto, Shun Sasaki, Tomoko Jogo, Qingjiang Hu, Yasuo Tsuda, Koji Ando, Yuichiro Nakashima, Hiroshi Saeki, Masaki Mori

    International Journal of Clinical Oncology   24 ( 11 )   1397 - 1405   2019.11

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    DOI: 10.1007/s10147-019-01509-8

  • Postoperative development of sarcopenia is a strong predictor of a poor prognosis in patients with adenocarcinoma of the esophagogastric junction and upper gastric cancer Reviewed

    Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Qingjiang Hu, Yasuo Tsuda, Koichi Kimura, Ryota Nakanishi, Nobuhide Kubo, Kouji Andou, Eiji Oki, Tetsuo Ikeda, Yoshihiko Maehara

    American Journal of Surgery   217 ( 4 )   757 - 763   2019.4

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    DOI: 10.1016/j.amjsurg.2018.07.003

  • Postoperative Skeletal Muscle Loss Predicts Poor Prognosis of Adenocarcinoma of Upper Stomach and Esophagogastric Junction Reviewed

    Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Koichi Kimura, Kouji Andou, Eiji Oki, Tetsuo Ikeda, Yoshihiko Maehara

    World journal of surgery   43 ( 4 )   1068 - 1075   2019.4

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    DOI: 10.1007/s00268-018-4873-6

  • Short- and long-term outcomes of surgical treatment for remnant gastric cancer after distal gastrectomy Reviewed

    Yu Nakaji, Hiroshi Saeki, Kensuke Kudou, Ryota Nakanishi, Masahiko Sugiyama, Yuichiro Nakashima, Kouji Andou, Yoshinao Oda, Eiji Oki, Yoshihiko Maehara

    Anticancer research   39 ( 3 )   1411 - 1415   2019.3

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    DOI: 10.21873/anticanres.13256

  • Effect of lateral lymph node dissection for mid and low rectal cancer An ad-hoc analysis of the ACTS-RC (JFMC35-C1) randomized clinical trial Reviewed

    Eiji Oki, Mototsugu Shimokawa, Kouji Andou, Akihiko Murata, Takao Takahashi, Kiyoshi Maeda, Tetsuya Kusumoto, Yoshinori Munemoto, Ryota Nakanishi, Yuichiro Nakashima, Hiroshi Saeki, Yoshihiko Maehara

    Surgery (United States)   165 ( 3 )   586 - 592   2019.3

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    DOI: 10.1016/j.surg.2018.08.027

  • C-reactive protein/albumin ratio is a poor prognostic factor of esophagogastric junction and upper gastric cancer Reviewed

    Kensuke Kudou, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, Tetsuro Kawazoe, Yasuhiro Haruta, Yoshiaki Fujimoto, Hiroya Matsuoka, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Qingjiang Hu, Yasuo Tsuda, Koichi Kimura, Kouji Andou, Eiji Oki, Tetsuo Ikeda, Yoshihiko Maehara

    Journal of Gastroenterology and Hepatology (Australia)   34 ( 2 )   355 - 363   2019.2

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    DOI: 10.1111/jgh.14442

  • The balance of forces generated by kinesins controls spindle polarity and chromosomal heterogeneity in tetraploid cells Reviewed

    Sei Shu, Makoto Iimori, Takeshi Wakasa, Koji Ando, Hiroshi Saeki, Yoshinao Oda, Eiji Oki, Yoshihiko Maehara

    Journal of cell science   132 ( 24 )   2019.1

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    DOI: 10.1242/jcs.231530

  • Skeletal muscle loss during systemic chemotherapy for colorectal cancer indicates treatment response a pooled analysis of a multicenter clinical trial (KSCC 1605-A) Reviewed

    Shun Sasaki, Eiji Oki, Hiroshi Saeki, Takayuki Shimose, Sanae Sakamoto, Qingjiang Hu, Kensuke Kudo, Yasuo Tsuda, Yuichiro Nakashima, Kouji Andou, Yoshito Akagi, Yoshihiro Kakeji, Hideo Baba, Yoshihiko Maehara

    International Journal of Clinical Oncology   2019.1

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    DOI: 10.1007/s10147-019-01460-8

  • Tumor suppressor KIF1Bβ regulates mitochondrial apoptosis in collaboration with YME1L1 Reviewed

    2019.1

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    KIF1Bβ, a member of the kinesin superfamily of motor proteins, is a haploinsufficient tumor suppressor mapped to chromosome 1p36.2, which is frequently deleted in neural crest–derived tumors, including neuroblastoma and pheochromocytoma. While KIF1Bβ acts downstream of the nerve growth factor (NGF) pathway to induce apoptosis, further molecular functions of this gene product have largely been unexplored. In this study, we report that KIF1Bβ destabilizes the morphological structure of mitochondria, which is critical for cell survival and apoptosis. We identified YME1L1, a mitochondrial metalloprotease responsible for the cleavage of the mitochondrial GTPase OPA1, as a physical interacting partner of KIF1Bβ. KIF1Bβ interacted with YME1L1 through its death-inducing region, as initiated the protease activity of YME1L1 to cleave the long forms of OPA1, resulting in mitochondrial fragmentation. Overexpression of YME1L1 promoted apoptosis, while knockdown of YME1L1 promoted cell growth. High YME1L1 expression was significantly associated with a better prognosis in neuroblastoma. Furthermore, in NGF-deprived PC12 cells, KIF1Bβ and YME1L1 were upregulated, accompanied by mitochondrial fragmentation and apoptotic cell death. Small interfering RNA–mediated knockdown of either protein alone, however, remarkably inhibited the NGF depletion–induced apoptosis. Our findings indicate that tumor suppressor KIF1Bβ plays an important role in intrinsic mitochondria–mediated apoptosis through the regulation of structural and functional dynamics of mitochondria in collaboration with YME1L1. Dysfunction of the KIF1Bβ/YME1L1/OPA1 mechanism may be involved in malignant biological features of neural crest–derived tumors as well as the initiation and progression of neurodegenerative diseases.

    DOI: 10.1002/mc.22997

  • “Energy-less technique” with mini-clips for recurrent laryngeal nerve lymph node dissection in prone thoracoscopic esophagectomy for esophageal cancer Reviewed

    216 ( 6 )   1212 - 1214   2018.12

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    Background: Meticulous recurrent laryngeal nerve (RLN) lymph node dissection in thoracoscopic esophagectomy for esophageal cancer often results in RLN paralysis. Methods: We had attempted to simply cut the vessels around RLN sharply with scissors without using energy device in order to prevent RLN paralysis. However, these procedures often result in minor bleeding. Since we introduced the use of mini-clips for hemostasis before cutting the vessels with scissors, we herein compared the surgical results between before and after the introduction of use of mini-clips. Results: With regard to RLN paralysis, the incidence was 24.0% in the before group; this incidence went down to 5.1% in the after group (P = 0.0259). Moreover, length of hospital stay after surgery was significantly shortened, from 36.1 days to 22.0 days, after the introduction of energy-less techniques with mini-clips (P = 0.0075). Conclusions: Our data demonstrated that this technique contributed to prevent RLN paralysis and to shorten the patient's length of hospital stay.

    DOI: 10.1016/j.amjsurg.2017.10.033

  • CD44v9 is associated with epithelial-mesenchymal transition and poor outcomes in esophageal squamous cell carcinoma Reviewed

    Daisuke Taniguchi, Hiroshi Saeki, Yuichiro Nakashima, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Kouji Andou, Eiji Oki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   7 ( 12 )   6258 - 6268   2018.12

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    DOI: 10.1002/cam4.1874

  • Neoadjuvant chemotherapy versus chemoradiotherapy for patients with esophageal squamous cell carcinoma Reviewed

    Yuichiro Nakashima, Hiroshi Saeki, Qingjiang Hu, Yasuo Tsuda, Yuichi Hisamatsu, Kouji Andou, Eiji Oki, Yoshihiko Maehara

    Anticancer research   38 ( 12 )   6809 - 6814   2018.12

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    DOI: 10.21873/anticanres.13053

  • Laparoscopic Proximal Gastrectomy Maintains Body Weight and Skeletal Muscle Better Than Total Gastrectomy Reviewed

    Masahiko Sugiyama, Eiji Oki, Kouji Andou, Yuichiro Nakashima, Hiroshi Saeki, Yoshihiko Maehara

    World journal of surgery   42 ( 10 )   3270 - 3276   2018.10

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    DOI: 10.1007/s00268-018-4625-7

  • Neoadjuvant Chemoradiotherapy for Patients with cT3/Nearly T4 Esophageal Cancer Is Sarcopenia Correlated with Postoperative Complications and Prognosis? Reviewed

    Hiroshi Saeki, Yuichiro Nakashima, Kensuke Kudou, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Ryota Nakanishi, Nobuhide Kubo, Kouji Andou, Akira Kabashima, Eiji Oki, Yoshihiko Maehara

    World journal of surgery   42 ( 9 )   2894 - 2901   2018.9

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    DOI: 10.1007/s00268-018-4554-5

  • Developing a Phosphospecific IHC Assay as a Predictive Biomarker for Topoisomerase I Inhibitors Reviewed

    Koji Ando, Yara Hamade Tohme, Adithi Srinivasiah, Julian Taylor-Parker, Yevgeniya Harrington, Ankur K. Shah, Eiji Oki, Mohan Brahmandam, Ajit K. Bharti

    Journal of Histochemistry and Cytochemistry   66 ( 8 )   549 - 561   2018.8

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    DOI: 10.1369/0022155418766503

  • Protein Expression of Programmed Death 1 Ligand 1 and HER2 in Gastric Carcinoma Reviewed

    Eiji Oki, Shinji Okano, Hiroshi Saeki, Yuichiro Umemoto, Koji Teraishi, Yu Nakaji, Kouji Andou, Yoko Zaitsu, Nami Yamashita, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Yoshinao Oda, Yoshihiko Maehara

    Oncology (Switzerland)   93 ( 6 )   387 - 394   2017.12

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    DOI: 10.1159/000479231

  • Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest Reviewed

    Yasuo Tsuda, Makoto Iimori, Yuichiro Nakashima, Ryota Nakanishi, Kouji Andou, Kippei Ohgaki, Hiroyuki Kitao, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

    Scientific reports   7 ( 1 )   2017.12

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    DOI: 10.1038/s41598-017-17002-z

  • Chemoradiotherapy for solitary skeletal muscle metastasis from oesophageal cancer Case report and brief literature review Reviewed

    Yoshiaki Fujimoto, Yuichiro Nakashima, Shun Sasaki, Tomoko Jogo, Kosuke Hirose, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Yu Nakaji, Ryota Nakanishi, Kouji Andou, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   37 ( 10 )   5687 - 5691   2017.10

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    DOI: 10.21873/anticanres.12005

  • A prospective study of XELIRI plus bevacizumab as a first-line therapy in Japanese patients with unresectable or recurrent colorectal cancer (KSCC1101) Reviewed

    , Kouji Andou, Yasunori Emi, Toyokuni Suenaga, Masahiro Hamanoue, Soichiro Maekawa, Yasuo Sakamoto, Seiichiro Kai, Hironaga Satake, Takayuki Shimose, Mototsugu Shimokawa, Hiroshi Saeki, Eiji Oki, Kenji Sakai, Yoshito Akagi, Hideo Baba, Yoshihiko Maehara

    International Journal of Clinical Oncology   22 ( 5 )   913 - 920   2017.10

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    DOI: 10.1007/s10147-017-1140-z

  • Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway. Reviewed

    Koji Ando

    Oncogene   43733   2017.7

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  • High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer Reviewed

    Sho Nishimura, Eiji Oki, Kouji Andou, Makoto Iimori, Yu Nakaji, Yuichiro Nakashima, Hiroshi Saeki, Yoshinao Oda, Yoshihiko Maehara

    Cancer Medicine   6 ( 6 )   1453 - 1464   2017.6

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    DOI: 10.1002/cam4.1090

  • The Expression of CCAT2, a Novel Long Noncoding RNA Transcript, and rs6983267 Single-Nucleotide Polymorphism Genotypes in Colorectal Cancers Reviewed

    Yuta Kasagi, Eiji Oki, Kouji Andou, Shuhei Ito, Tomohiro Iguchi, Masahiko Sugiyama, Yuichiro Nakashima, Kippei Ohgaki, Hiroshi Saeki, Koshi Mimori, Yoshihiko Maehara

    Oncology (Switzerland)   92 ( 1 )   48 - 54   2017.1

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    DOI: 10.1159/000452143

  • Prognostic value of BRAF V600E mutation and microsatellite instability in Japanese patients with sporadic colorectal cancer Reviewed

    Yu Nakaji, Eiji Oki, Ryota Nakanishi, Kouji Andou, Masahiko Sugiyama, Yuichiro Nakashima, Nami Yamashita, Hiroshi Saeki, Yoshinao Oda, Yoshihiko Maehara

    Journal of Cancer Research and Clinical Oncology   143 ( 1 )   151 - 160   2017.1

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    DOI: 10.1007/s00432-016-2275-4

  • Expression of PD-L1 and HLA Class I in Esophageal Squamous Cell Carcinoma Prognostic Factors for Patient Outcome Reviewed

    Shuhei Ito, Shinji Okano, Masaru Morita, Hiroshi Saeki, Satoshi Tsutsumi, Hiroshi Tsukihara, Yuichiro Nakashima, Kouji Andou, Yu Imamura, Kippei Ohgaki, Eiji Oki, Hiroyuki Kitao, Koshi Mimori, Yoshihiko Maehara

    Annals of Surgical Oncology   23   508 - 515   2016.8

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    DOI: 10.1245/s10434-016-5376-z

  • Gastric Cancer Patients with High PLK1 Expression and DNA Aneuploidy Correlate with Poor Prognosis Reviewed

    hajime otsu, Makoto Iimori, Kouji Andou, Hiroshi Saeki, Shinichi Aishima, Yoshinao Oda, Masaru Morita, Keitaro Matsuo, Hiroyuki Kitao, Eiji Oki, Yoshihiko Maehara

    Oncology (Switzerland)   91 ( 1 )   31 - 40   2016.7

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    DOI: 10.1159/000445952

  • Effect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer Reviewed

    Yuichi Hisamatsu, Eiji Oki, hajime otsu, Kouji Andou, Hiroshi Saeki, Eriko Tokunaga, Shinichi Aishima, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

    Annals of Surgical Oncology   23 ( 6 )   1986 - 1992   2016.6

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    DOI: 10.1245/s10434-016-5097-3

  • Current status of and perspectives regarding neoadjuvant chemoradiotherapy for locally advanced esophageal squamous cell carcinoma Reviewed

    Hiroshi Saeki, Yuichiro Nakashima, Yoko Zaitsu, Yasuo Tsuda, Yuta Kasagi, Kouji Andou, Yu Imamura, Kippei Ohgaki, Shuhei Ito, Yasue Kimura, Akinori Egashira, Eiji Oki, Masaru Morita, Yoshihiko Maehara

    Surgery today   46 ( 3 )   261 - 267   2016.3

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    DOI: 10.1007/s00595-015-1144-0

  • Real-Time Accurate Identification of Tumor Site Using a Mobile X-Ray Image-Intensifier System during Laparoscopic Gastrectomy Reviewed

    Yu Imamura, Eiji Oki, Kippei Ohgaki, Yuichiro Nakashima, Kouji Andou, Satoshi Tsutsumi, Daisuke Tsurumaru, Hiroshi Saeki, Hideo Baba, Yoshihiko Maehara

    Journal of the American College of Surgeons   222 ( 2 )   e1 - e7   2016.2

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    DOI: 10.1016/j.jamcollsurg.2015.11.001

  • Incidence of Venous Thromboembolism Following Laparoscopic Surgery for Gastrointestinal Cancer A Single-Center, Prospective Cohort Study Reviewed

    Yasue Kimura, Eiji Oki, Kouji Andou, Hiroshi Saeki, Tetsuya Kusumoto, Yoshihiko Maehara

    World journal of surgery   40 ( 2 )   309 - 314   2016.2

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    DOI: 10.1007/s00268-015-3234-y

  • Number of lymph node metastases may indicate the regimen for adjuvant chemotherapy in patients with stage III colorectal cancer Reviewed

    Kouji Andou, Eiji Oki, Hiroshi Saeki, Yuta Kasagi, Yasuo Tsuda, Yoko Zaitsu, Yuichiro Nakashima, Yu Imamura, Kippei Ohgaki, Yoshihiko Maehara

    Anticancer Research   35 ( 11 )   6207 - 6211   2015.11

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  • Pharyngo-laryngo-esophagectomy and reconstruction with a gastric tube for corrosive pharyngoesophagitis Reviewed

    Hiroyuki Kawano, Masaru Morita, hajime otsu, Kouji Andou, Yukiharu Hiyoshi, Shuhei Ito, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

    Esophagus   12 ( 4 )   360 - 364   2015.10

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    DOI: 10.1007/s10388-014-0466-0

  • Treatment results of two-stage operation for the patients with esophageal cancer concomitant with liver dysfunction Reviewed

    Mitsuhiro Yasuda, Hiroshi Saeki, Yuichiro Nakashima, Takafumi Yukaya, Satoshi Tsutsumi, Hirotada Tajiri, Yoko Zaitsu, Yasuo Tsuda, Yuta Kasagi, Kouji Andou, Yu Imamura, Kippei Ohgaki, Tomohiko Akahoshi, Eiji Oki, Yoshihiko Maehara

    Journal of Medical Investigation   62 ( 3 )   149 - 153   2015.9

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    DOI: 10.2152/jmi.62.149

  • Recent advances in multidisciplinary approach for rectal cancer Reviewed

    Eiji Oki, Kouji Andou, Yuta Kasagi, Yoko Zaitsu, Masahiko Sugiyama, Yuichiro Nakashima, Hideto Sonoda, Kippei Ohgaki, Hiroshi Saeki, Yoshihiko Maehara

    International Journal of Clinical Oncology   20 ( 4 )   641 - 649   2015.8

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    DOI: 10.1007/s10147-015-0858-8

  • Long-term treatment with panitumumab monotherapy for recurrent colorectal cancer Reviewed

    Kouji Andou, Eiji Oki, Hiroshi Saeki, Yuichiro Nakashima, Yoshihiko Maehara

    International Cancer Conference Journal   4 ( 3 )   151   2015.7

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  • Acute liver failure due to regorafenib may be caused by impaired liver blood flow A case report Reviewed

    Takaki Akamine, Kouji Andou, Eiji Oki, Hiroshi Saeki, Yuichiro Nakashima, Yu Imamura, Kippei Ohgaki, Yoshihiko Maehara

    Anticancer Research   35 ( 7 )   4037 - 4042   2015.7

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  • The use of a circular side stapling technique in laparoscopic low anterior resection for rectal cancer Experience of 30 serial cases Reviewed

    Eiji Oki, Kouji Andou, Hiroshi Saeki, Yuichiro Nakashima, Yasue Kimura, Yukiharu Hiyoshi, Yu Imamura, Kippei Ohgaki, Shuhei Ito, Masaru Morita, Tetsuo Ikeda, Yoshihiko Maehara

    International Surgery   100 ( 6 )   979 - 983   2015.6

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    DOI: 10.9738/INTSURG-D-14-00202.1

  • Hyperthermia combined with chemotherapy for patients with residual or recurrent oesophageal cancer after definitive chemoradiotherapy Reviewed

    Yoshihiko Maehara, Sho Nishimura, Hiroshi Saeki, Tomonori Nakanoko, Yuta Kasagi, Yasuo Tsuda, Yoko Zaitsu, Kouji Andou, Yuichiro Nakashima, Y. U. Imamura, Kippei Ohgaki, Eiji Oki, Ohga Saiji, Katsumasa Nakamura, Masaru Morita

    Anticancer research   35 ( 4 )   2299 - 2304   2015.4

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  • Trifluridine induces p53-dependent sustained G2 phase arrest with its massive misincorporation into DNA and few DNA strand breaks Reviewed

    Kazuaki Matsuoka, Makoto Iimori, Shinichiro Niimi, Hiroshi Tsukihara, Sugiko Watanabe, Shinichi Kiyonari, Mamoru Kiniwa, Kouji Andou, Eriko Tokunaga, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Hiroyuki Kitao

    Molecular Cancer Therapeutics   14 ( 4 )   1004 - 1013   2015.1

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    DOI: 10.1158/1535-7163.MCT-14-0236

  • Assessment of surgical treatment and postoperative nutrition in gastric cancer patients older than 80 years Reviewed

    Tomonori Nakanoko, Yoshihiro Kakeji, Kouji Andou, Yuichiro Nakashima, Kippei Ohgaki, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshihiko Maehara

    Anticancer research   35 ( 1 )   511 - 516   2015.1

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  • Cardiac tamponade due to bleeding as a potential lethal complication after surgery for esophageal cancer Reviewed

    Shuhei Ito, Masaru Morita, Sho Nanbara, Yu Nakaji, Kouji Andou, Yukiharu Hiyoshi, Tatsuro Okamoto, Hiroshi Saeki, Eiji Oki, Hirofumi Kawanaka, Yoshihisa Tanoue, Yoshihiko Maehara

    Anticancer research   35 ( 1 )   407 - 412   2015.1

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  • Clinical Significance of Surgical Resection for the Recurrence of Esophageal Cancer After Radical Esophagectomy Reviewed

    Yukiharu Hiyoshi, Masaru Morita, Hiroyuki Kawano, hajime otsu, Kouji Andou, Shuhei Ito, Yuji Miyamoto, Yasuo Sakamoto, Hiroshi Saeki, Eiji Oki, Tetsuo Ikeda, Hideo Baba, Yoshihiko Maehara

    Annals of Surgical Oncology   22 ( 1 )   240 - 246   2015.1

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    DOI: 10.1245/s10434-014-3970-5

  • Clinical significance of adjuvant surgery following chemotherapy for patients with initially unresectable stage IV gastric cancer Reviewed

    Shuhei Ito, Eiji Oki, Yuichiro Nakashima, Kouji Andou, Yukiharu Hiyoshi, Kippei Ohgaki, Hiroshi Saeki, Masaru Morita, Yoshihisa Sakaguchi, Yoshihiko Maehara

    Anticancer research   35 ( 1 )   401 - 406   2015.1

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  • Clinicopathological Characteristics of Esophageal Squamous Cell Carcinoma in Patients Younger Than 50 years Reviewed

    22 ( 1 )   311 - 315   2015.1

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    Purpose: This study clarifies age differences in clinicopathologic characteristics and risk factor exposure of patients who have undergone esophagectomy for esophageal cancer (EC).
    Methods: Clinical results of esophagectomy were compared between 22 patients younger than 50years of age (Group I) and 327 patients older than 50 years of age (Group II) with esophageal squamous cell carcinoma.
    Results: The two groups did not significantly differ in clinicopathological characteristics, including prognosis. Postoperative pulmonary complication incidence rates were 4.2% (Group I) and 14.4% (Group II). In Group I, the incidence of multiple ECs was 36.4%, and association with head and neck cancer was 31.8%, which were significantly higher than in Group II (13.4%, p=0.021; and 9.2%, p=0.015, respectively). Furthermore, the patients in Group I with multiple cancers were almost all heavy smokers and/or users of alcohol.
    Conclusions: These results suggest that multiple upper aerodigestive tract cancers are associated with heavy exposure to risk factors in patients younger than 50years of age.

    DOI: 10.1245/s10434-014-3856-6

  • Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer Reviewed

    hajime otsu, Eiji Oki, Ayae Ikawa-Yoshida, Hiroyuki Kawano, Kouji Andou, Satoshi Ida, Yasue Kimura, Shinichi Aishima, Hiroshi Saeki, Masaru Morita, Shunji Kohnoe, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   35 ( 4 )   2441 - 2446   2015.1

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  • Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer Reviewed

    Kouji Andou, Eiji Oki, Hiroshi Saeki, Zhao Yan, Yasuo Tsuda, Gen Hidaka, Yuta Kasagi, hajime otsu, Hiroyuki Kawano, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

    Cancer Medicine   4 ( 1 )   75 - 83   2015.1

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    DOI: 10.1002/cam4.346

  • Endoscopic evaluation of clinical colorectal anastomotic leakage Reviewed

    Tetsuo Ikeda, Ryuichi Kumashiro, Kenji Taketani, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Tomohiko Akahoshi, Makoto Hashizume, Yoshihiko Maehara

    Journal of Surgical Research   193 ( 1 )   126 - 134   2015.1

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    DOI: 10.1016/j.jss.2014.07.009

  • Esophagectomy-related thoracic duct injury detected by lymphoscintigraphy with 99mTc-diethylenetriamine pentaacetic acid-human serum albumin report of a case Reviewed

    Yasuo Tsuda, Masaru Morita, Hiroshi Saeki, Kouji Andou, Satoshi Ida, Yasue Kimura, Eiji Oki, Takefumi Ohga, Tetsuya Kusumoto, Koichiro Abe, Shingo Baba, Takuro Isoda, Yoshihiko Maehara

    Surgery today   45 ( 4 )   517 - 521   2015.1

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    DOI: 10.1007/s00595-014-0968-3

  • Evaluation of techniques to prevent colorectal anastomotic leakage Reviewed

    Tetsuo Ikeda, Ryuichi Kumashiro, Eiji Oki, Kenji Taketani, Kouji Andou, Shinichi Aishima, Tomohiko Akahoshi, Masaru Morita, Yoshihiko Maehara

    Journal of Surgical Research   194 ( 2 )   450 - 457   2015.1

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    DOI: 10.1016/j.jss.2014.11.045

  • Indocyanine Green Fluorescence Angiography for Quantitative Evaluation of Gastric Tube Perfusion in Patients Undergoing Esophagectomy Reviewed

    Takafumi Yukaya, Hiroshi Saeki, Yuta Kasagi, Yuichiro Nakashima, Kouji Andou, Yu Imamura, Kippei Ohgaki, Eiji Oki, Masaru Morita, Yoshihiko Maehara

    Journal of the American College of Surgeons   221 ( 2 )   e37 - e42   2015.1

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    DOI: 10.1016/j.jamcollsurg.2015.04.022

  • Laparoscopic total gastrectomy for RGC Four case reports Reviewed

    Shotaro Korehisa, Kippei Ohgaki, Takafumi Yukaya, Yoko Zaitu, Yasuo Tsuda, Yuta Kasagi, Kouji Andou, Yuichiro Nakashima, Yu Imamura, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara

    Anticancer Research   35 ( 9 )   5023 - 5026   2015.1

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  • Loss of heterozygosity of PTEN (Encoding phosphate and tensin homolog) associated with elevated HER2 expression is an adverse prognostic indicator in gastric cancer Reviewed

    Yoko Zaitsu, Eiji Oki, Kouji Andou, Satoshi Ida, Yasue Kimura, Hiroshi Saeki, Masaru Morita, Minako Hirahashi, Yoshinao Oda, Yoshihiko Maehara

    Oncology (Switzerland)   88 ( 3 )   189 - 194   2015.1

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    DOI: 10.1159/000368984

  • Erratum to Rad51 Expression Is a Useful Predictive Factor for the Efficacy of Neoadjuvant Chemoradiotherapy in Squamous Cell Carcinoma of the Esophagus [Ann Surg Oncol, 10.1245/S10434-013-3220-2] Reviewed

    Tomonori Nakanoko, Hiroshi Saeki, Masaru Morita, Yuichiro Nakashima, Kouji Andou, Eiji Oki, Takefumi Ohga, Yoshihiro Kakeji, Yasushi Toh, Yoshihiko Maehara

    Annals of Surgical Oncology   21 ( 4 )   2014.11

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    DOI: 10.1245/s10434-013-3332-8

  • Clinical Outcomes and Prognostic Factors After Surgery for Non-Occlusive Mesenteric Ischemia a Multicenter Study Reviewed

    Takafumi Yukaya, Hiroshi Saeki, Kenji Taketani, Kouji Andou, Satoshi Ida, Yasue Kimura, Eiji Oki, Mitsuhiro Yasuda, Masaru Morita, Ken Shirabe, Yoshihiko Maehara

    Journal of Gastrointestinal Surgery   18 ( 9 )   1642 - 1647   2014.9

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    DOI: 10.1007/s11605-014-2579-0

  • IgG4-related disease of the ileocecal region mimicking malignancy A case report Reviewed

    Yukiharu Hiyoshi, Eiji Oki, Yoko Zaitsu, Kouji Andou, Shuhei Ito, Hiroshi Saeki, Masaru Morita, Hidetaka Yamamoto, Hideo Baba, Yoshihiko Maehara

    International Journal of Surgery Case Reports   5 ( 10 )   669 - 672   2014.8

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    DOI: 10.1016/j.ijscr.2014.08.003

  • Pure laparoscopic right-sided hepatectomy in the semi-prone position for synchronous colorectal cancer with liver metastases Reviewed

    Satoshi Ida, Eiji Oki, Kouji Andou, Yasue Kimura, Yo ichi Yamashita, Hiroshi Saeki, Toru Ikegami, Tomoharu Yoshizumi, Masayuki Watanabe, Masaru Morita, Ken Shirabe, Tetsuya Kusumoto, Tetsuo Ikeda, Hideo Baba, Yoshihiko Maehara

    Asian journal of endoscopic surgery   7 ( 2 )   133 - 137   2014.5

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    DOI: 10.1111/ases.12098

  • Gender differences in prognosis after esophagectomy for esophageal cancer Reviewed

    Masaru Morita, hajime otsu, Hiroyuki Kawano, Yuta Kasagi, Yasue Kimura, Hiroshi Saeki, Kouji Andou, Satoshi Ida, Eiji Oki, Eriko Tokunaga, Tetsuo Ikeda, Tetsuya Kusumoto, Yoshihiko Maehara

    Surgery today   44 ( 3 )   505 - 512   2014.3

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    DOI: 10.1007/s00595-013-0573-x

  • Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers Reviewed

    Kenichi Honma, Ryota Nakanishi, Tomonori Nakanoko, Kouji Andou, Hiroshi Saeki, Eiji Oki, Makoto Iimori, Hiroyuki Kitao, Yoshihiro Kakeji, Yoshihiko Maehara

    Surgery Today   44 ( 3 )   454 - 461   2014.3

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    DOI: 10.1007/s00595-013-0581-x

  • Rad51 expression is a useful predictive factor for the efficacy of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the esophagus Reviewed

    Tomonori Nakanoko, Hiroshi Saeki, Masaru Morita, Yuichiro Nakashima, Kouji Andou, Eiji Oki, Takefumi Ohga, Yoshihiro Kakeji, Yasushi Toh, Yoshihiko Maehara

    Annals of Surgical Oncology   21 ( 2 )   597 - 604   2014.2

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    DOI: 10.1245/s10434-013-3220-2

  • Technical improvement of total pharyngo-laryngo-esophagectomy for esophageal cancer and head and neck cancer Reviewed

    Masaru Morita, Hiroshi Saeki, Shuhei Ito, Keisuke Ikeda, Nami Yamashita, Kouji Andou, Yukiharu Hiyoshi, Satoshi Ida, Eriko Tokunaga, Hideaki Uchiyama, Eiji Oki, Tetsuo Ikeda, Sei Yoshida, Torahiko Nakashima, Yoshihiko Maehara

    Annals of Surgical Oncology   21 ( 5 )   1671 - 1677   2014.1

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    DOI: 10.1245/s10434-013-3453-0

  • Aberrations of BUBR1 and TP53 gene mutually associated with chromosomal instability in human colorectal cancer Reviewed

    Yan Zhao, Kouji Andou, Eiji Oki, Ayae Ikawa-Yoshida, Satoshi Ida, Yasue Kimura, Hiroshi Saeki, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

    Anticancer research   34 ( 10 )   5421 - 5427   2014.1

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  • Book-binding technique for billroth i anastomosis during totally laparoscopic distal gastrectomy Reviewed

    Eiji Oki, Yasuo Tsuda, Hiroshi Saeki, Kouji Andou, Yu Imamura, Yuichiro Nakashima, Kippei Ohgaki, Masaru Morita, Tetsuo Ikeda, Yoshihiko Maehara

    Journal of the American College of Surgeons   219 ( 6 )   e69 - e73   2014.1

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    DOI: 10.1016/j.jamcollsurg.2014.09.001

  • Chromosomal Instability Associated with Global DNA Hypomethylation is Associated with the Initiation and Progression of Esophageal Squamous Cell Carcinoma Reviewed

    Hiroyuki Kawano, Hiroshi Saeki, Hiroyuki Kitao, Yasuo Tsuda, hajime otsu, Kouji Andou, Shuhei Ito, Akinori Egashira, Eiji Oki, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

    Annals of Surgical Oncology   21 ( 4 )   696 - 702   2014.1

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    DOI: 10.1245/s10434-014-3818-z

  • Impact of second-line and later cetuximab-containing therapy and KRAS genotypes in patients with metastatic colorectal cancer A multicenter study in Japan Reviewed

    Hiroshi Saeki, Yasunori Emi, Ryuichi Kumashiro, hajime otsu, Hiroyuki Kawano, Kouji Andou, Satoshi Ida, Yasue Kimura, Eriko Tokunaga, Eiji Oki, Masaru Morita, Mototsugu Shimokawa, Yoshihiko Maehara

    Surgery today   44 ( 8 )   1457 - 1464   2014.1

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    DOI: 10.1007/s00595-013-0716-0

  • Intratumoral lymphangiogenesis and prognostic significance of VEGFC expression in gastric cancer Reviewed

    Keisuke Ikeda, Eiji Oki, Hiroshi Saeki, Kouji Andou, Masaru Morita, Yoshinao Oda, Masakazu Imamura, Yoshiniro Kakeji, Yoshihiko Maehara

    Anticancer research   34 ( 8 )   3911 - 3916   2014.1

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  • Living donor liver transplantation followed by total gastrectomy - A two-stage planed operative strategy for early gastric cancer concomitant with decompensated liver cirrhosis Reviewed

    Sho Nishimura, Hiroshi Saeki, Toru Ikegami, Kouji Andou, Yo Ichi Yamashita, Eiji Oki, Tomoharu Yoshizumi, Masaru Morita, Ken Shirabe, Yoshihiko Maehara

    Anticancer research   34 ( 8 )   4307 - 4310   2014.1

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  • Mortalin is a prognostic factor of gastric cancer with normal p53 function Reviewed

    Kouji Andou, Eiji Oki, Yan Zhao, Ayae Ikawa-Yoshida, Hiroyuki Kitao, Hiroshi Saeki, Yasue Kimura, Satoshi Ida, Masaru Morita, Tetsuya Kusumoto, Yoshihiko Maehara

    Gastric Cancer   17 ( 2 )   255 - 262   2014.1

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    DOI: 10.1007/s10120-013-0279-1

  • Non-cirrhotic portal-systemic encephalopathy caused by enlargement of a splenorenal shunt after pancreaticoduodenectomy for locally advanced duodenal cancer Report of a case Reviewed

    Yuta Kasagi, Hiroshi Saeki, Tomohiko Akahoshi, Junji Kawasaki, Kouji Andou, Eiji Oki, Takefumi Ohga, Morimasa Tomikawa, Yoshihiro Kakeji, Ken Shirabe, Yoshihiko Maehara

    Surgery Today   44 ( 8 )   1573 - 1576   2014.1

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    DOI: 10.1007/s00595-013-0679-1

  • Nuclear expression of chemokine receptor CXCR4 indicates poorer prognosis in gastric cancer Reviewed

    Takanobu Masuda, Yuichiro Nakashima, Kouji Andou, Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   34 ( 11 )   6397 - 6403   2014.1

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  • Outcome of esophagojejunostomy during totally laparoscopic total gastrectomy A single-center retrospective study Reviewed

    Yukiharu Hiyoshi, Eiji Oki, Kouji Andou, Shuhei Ito, Hiroshi Saeki, Masaru Morita, Hideo Baba, Yoshihiko Maehara

    Anticancer research   34 ( 12 )   7227 - 7232   2014.1

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  • Significance of accurate human epidermal growth factor receptor-2 (HER2) evaluation as a new biomarker in gastric cancer Reviewed

    Yasue Kimura, Eiji Oki, Ayae Yoshida, Shinichi Aishima, Yoko Zaitsu, hajime otsu, Kouji Andou, Satoshi Ida, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshinao Oda, Yoshihiko Maehara

    Anticancer research   34 ( 8 )   4207 - 4212   2014.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Simultaneous resection of colorectal cancer and liver metastases in the right lobe using pure laparoscopic surgery Reviewed

    Kouji Andou, Eiji Oki, Tetsuo Ikeda, Hiroshi Saeki, Satoshi Ida, Yasue Kimura, Yuji Soejima, Masaru Morita, Ken Shirabe, Tetuya Kusumoto, Yoshihiko Maehara

    Surgery today   44 ( 8 )   1588 - 1592   2014.1

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    DOI: 10.1007/s00595-013-0801-4

  • Surgical resection of hypopharynx and cervical esophageal cancer with a history of esophagectomy for thoracic esophageal cancer Reviewed

    Satoshi Ida, Masaru Morita, Yukiharu Hiyoshi, Keisuke Ikeda, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Tetsuya Kusumoto, Sei Yoshida, Torahiko Nakashima, Masayuki Watanabe, Hideo Baba, Yoshihiko Maehara

    Annals of Surgical Oncology   21 ( 4 )   1175 - 1181   2014.1

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    DOI: 10.1245/s10434-013-3454-z

  • Surgical strategies for esophageal cancer associated with head and neck cancer Reviewed

    Masaru Morita, Hiroshi Saeki, Shuhei Ito, Yasue Kimura, Nami Yamashita, Kouji Andou, Yukiharu Hiyoshi, Eriko Tokunaga, Eiji Oki, Tetsuo Ikeda, Sei Yoshida, Torahiko Nakashima, Yoshihiko Maehara

    Surgery today   44 ( 9 )   1603 - 1610   2014.1

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    DOI: 10.1007/s00595-013-0713-3

  • Prognostic relevance of KRAS and BRAF mutations in Japanese patients with colorectal cancer Reviewed

    Ryota Nakanishi, Jun Harada, Munkhbold Tuul, Yan Zhao, Kouji Andou, Hiroshi Saeki, Eiji Oki, Takefumi Ohga, Hiroyuki Kitao, Yoshihiro Kakeji, Yoshihiko Maehara

    International Journal of Clinical Oncology   18 ( 6 )   1042 - 1048   2013.12

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    DOI: 10.1007/s10147-012-0501-x

  • Podoplanin is expressed at the invasive front of esophageal squamous cell carcinomas and is involved in collective cell invasion Reviewed

    Yuichiro Nakashima, Keiji Yoshinaga, Hiroyuki Kitao, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Yoshihiro Kakeji, Minako Hirahashi, Yoshinao Oda, Yoshihiko Maehara

    Cancer Science   104 ( 12 )   1718 - 1725   2013.12

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    DOI: 10.1111/cas.12286

  • Total laparoscopic distal gastrectomy for elderly patients with gastric cancer. Reviewed

    Eiji Oki, Yoshihisa Sakaguchi, Kippei Ohgaki, Hiroshi Saeki, Toru Ikegami, Kazuhito Minami, Yoichi Yamashita, Yasushi Toh, Yuji Soejima, Kouji Andou, Koshi Mimori, Masayuki Watanabe, Keishi Sugimachi, Hideaki Uchiyama, Tomoharu Yoshizumi, Hirofumi Kawanaka, Masaru Morita, Tetsuo Ikeda, Yoshihiko Maehara

    Fukuoka Acta Medica   104 ( 9 )   290 - 298   2013.9

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  • Multimodal treatment strategy for clinical T3 thoracic esophageal cancer Reviewed

    Hiroshi Saeki, Masaru Morita, Yasuo Tsuda, Gen Hidaka, Yuta Kasagi, Hiroyuki Kawano, hajime otsu, Kouji Andou, Yasue Kimura, Eiji Oki, Tetsuya Kusumoto, Yoshihiko Maehara

    Annals of Surgical Oncology   20 ( 13 )   4267 - 4273   2013.8

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    DOI: 10.1245/s10434-013-3192-2

  • A case of liver metastasis from gastric cancer responding completely to S-1/docetaxel chemotherapy Reviewed

    Hirokazu Kitahara, Eiji Oki, Hiroshi Saeki, Kouji Andou, Ken Shirabe, Shunji Kounoe, Shinichi Aishima, Yoshihiro Kakeji, Yoshihiko Maehara

    Japanese Journal of Cancer and Chemotherapy   40 ( 8 )   1093 - 1097   2013.8

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  • Surgical resection for esophageal cancer synchronously or metachronously associated with head and neck cancer Reviewed

    Masaru Morita, Hiroyuki Kawano, hajime otsu, Yasue Kimura, Hiroshi Saeki, Kouji Andou, Satoshi Ida, Eiji Oki, Tetsuo Ikeda, Tetsuya Kusumoto, Jun Ichi Fukushima, Torahiko Nakashima, Yoshihiko Maehara

    Annals of Surgical Oncology   20 ( 7 )   2434 - 2439   2013.7

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    DOI: 10.1245/s10434-013-2875-z

  • Newly developed liver-retraction method for laparoscopic gastric surgery using a silicone disc The Φ-shaped technique Reviewed

    216 ( 5 )   2013.5

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    DOI: 10.1016/j.jamcollsurg.2013.02.005

  • A case of panitumumab-responsive metastatic rectal cancer initially refractory to cetuximab Reviewed

    Yuta Kasagi, Eiji Oki, Kouji Andou, Yasue Kimura, Toru Ikegami, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Yoshihiko Maehara

    Case Reports in Oncology   6 ( 2 )   382 - 386   2013.5

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    DOI: 10.1159/000353781

  • Initial report of KSCC0803 Feasibility study of capecitabine as adjuvant chemotherapy for stage III colon cancer in Japanese patients Reviewed

    Yasunori Emi, Yoshihiro Kakeji, Eiji Oki, Hiroshi Saeki, Kouji Andou, Masaki Kitazono, Yoshihisa Sakaguchi, Masaru Morita, Hironori Samura, Yutaka Ogata, Yoshito Akagi, Shoji Natsugoe, Kazuo Shirouzu, Shoji Tokunaga, Florin Sirzen, Yoshihiko Maehara

    International Journal of Clinical Oncology   18 ( 2 )   254 - 259   2013.4

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    DOI: 10.1007/s10147-011-0371-7

  • Advances in esophageal surgery in elderly patients with thoracic esophageal cancer Reviewed

    Masaru Morita, hajime otsu, Hiroyuki Kawano, Ryuichi Kumashiro, Kenji Taketani, Yasue Kimura, Hiroshi Saeki, Kouji Andou, Satoshi Ida, Eiji Oki, Eriko Tokunaga, Tetsuo Ikeda, Tetsuya Kusumoto, Yoshihiko Maehara

    Anticancer Research   33 ( 4 )   1641 - 1648   2013.4

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  • [Patient with bulky duodenum GIST became complete resection possible after primary systemic therapy a case report]. Reviewed

    hajime otsu, Eiji Oki, Hiroyuki Kawano, Kouji Andou, Shuhei Ito, Keishi Sugimachi, Hiroshi Saeki, Hideaki Uchiyama, Yuji Soejima, Hirofumi Kawanaka, Masaru Morita, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Tetsuo Ikeda, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 12 )   585 - 588   2013.1

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  • Clinical results of preoperative CDDP/5-FU chemotherapy followed by surgery for patients with clinical stage II/III thoracic esophageal cancer. Reviewed

    Yuta Kasagi, Hiroshi Saeki, Kouji Andou, Yukiharu Hiyoshi, Shuhei Ito, Keishi Sugimachi, Yo Ichi Yamashita, Eiji Oki, Hideaki Uchiyama, Hirofumi Kawanaka, Masaru Morita, Tetsuo Ikeda, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 12 )   523 - 529   2013.1

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  • Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells Reviewed

    Ayae Ikawa-Yoshida, Kouji Andou, Eiji Oki, Hiroshi Saeki, Ryuichi Kumashiro, Kenji Taketani, Satoshi Ida, Eriko Tokunaga, Hiroyuki Kitao, Masaru Morita, Yoshihiko Maehara

    Cancer Medicine   2 ( 4 )   447 - 456   2013.1

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    DOI: 10.1002/cam4.101

  • Laparoscopic gastrectomy for gastric cancer with peritoneal dissemination after induction chemotherapy Reviewed

    Satoshi Tsutsumi, Eiji Oki, Satoshi Ida, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Masaru Morita, Tetsuya Kusumoto, Tetsuo Ikeda, Yoshihiko Maehara

    Case Reports in Gastroenterology   7 ( 3 )   516 - 521   2013.1

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    DOI: 10.1159/000357591

  • Minimally invasive total pharyng-laryngo-esophagectomy and reconstruction with gastric tube report of three cases. Reviewed

    Yasue Kimura, Masaru Morita, Hiroshi Saeki, Tetsuo Ikeda, Kouji Andou, Eiji Oki, Keishi Sugimachi, Yo Ichi Yamashita, Hideaki Uchiyama, Hirofumi Kawanaka, Mitsuhiko Ohta, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Sei Yoshida, Torahiko Nakashima, Masayuki Watanabe, Toshiya Furuta, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 11 )   442 - 448   2013.1

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  • Progression from laparoscopic-assisted to totally laparoscopic distal gastrectomy Comparison of circular stapler (i-DST) and linear stapler (BBT) for intracorporeal anastomosis Reviewed

    Tetsuo Ikeda, Hiroyuki Kawano, Yuichi Hisamatsu, Kouji Andou, Hiroshi Saeki, Eiji Oki, Takefumi Ohga, Yoshihiro Kakeji, Shunichi Tsujitani, Shunji Kohnoe, Yoshihiko Maehara

    Surgical endoscopy   27 ( 1 )   325 - 332   2013.1

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    DOI: 10.1007/s00464-012-2433-y

  • Relevance of totally laparoscopic gastrectomy for patients with advanced gastric cancer. Reviewed

    Hiroshi Saeki, Eiji Oki, Yasuo Tsuda, Kouji Andou, Yukiharu Hiyoshi, Shuhei Ito, Masaru Morita, Tetsuo Ikeda, Keishi Sugimachi, Yo Ichi Yamashita, Toru Ikegami, Hideaki Uchiyama, Tomoharu Yoshizumi, Yuji Soejima, Hirofumi Kawanaka, Koshi Mimori, Masayuki Watanabe, Yoshihiko Maehara

    Fukuoka igaku zasshi = Hukuoka acta medica   104 ( 11 )   405 - 412   2013.1

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  • The early discontinuation of adjuvant hormone therapy is associated with a poor prognosis in Japanese breast cancer patients Reviewed

    Kenji Taketani, Eriko Tokunaga, Nami Yamashita, Kimihiro Tanaka, Sayuri Akiyoshi, Satoko Okada, Kouji Andou, Yasue Kimura, Hiroshi Saeki, Eiji Oki, Masaru Morita, Tetsuya Kusumoto, Yoshihiko Maehara

    Surgery Today   44 ( 10 )   1841 - 1846   2013.1

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    DOI: 10.1007/s00595-013-0762-7

  • Patterns and time of recurrence after complete resection of esophageal cancer Reviewed

    Masahiko Sugiyama, Masaru Morita, Rintaro Yoshida, Kouji Andou, Akinori Egashira, Ohga Takefumi, Hiroshi Saeki, Eiji Oki, Yoshihiro Kakeji, Yoshihisa Sakaguchi, Yoshihiko Maehara

    Surgery today   42 ( 8 )   752 - 758   2012.8

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    DOI: 10.1007/s00595-012-0133-9

  • Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers Reviewed

    Eiji Oki, Yuichi Hisamatsu, Kouji Andou, Hiroshi Saeki, Yoshihiro Kakeji, Yoshihiko Maehara

    Journal of Gastroenterology   47 ( 4 )   351 - 358   2012.4

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    DOI: 10.1007/s00535-012-0565-4

  • Secondary resistance of extra-gastrointestinal stromal tumors to imatinib mesylate Report of a case Reviewed

    Kouji Andou, Eiji Oki, Masahiko Sugiyama, Yan Zhao, Aya Kojima, Hidetaka Yamamoto, Yoichi Yamashita, Hiroshi Saeki, Akinobu Taketomi, Masaru Morita, Yoshihiro Kakeji, Shunichi Tsujitani, Yoshihiko Maehara

    Surgery Today   41 ( 9 )   1290 - 1293   2011.9

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    DOI: 10.1007/s00595-010-4477-8

  • Impact of perioperative peripheral blood values on postoperative complications after esophageal surgery Reviewed

    Hiroshi Saeki, Takanobu Masuda, Satoko Okada, Kouji Andou, Masahiko Sugiyama, Keiji Yoshinaga, Kazuya Endo, Noriaki Sadanaga, Yasunori Emi, Yoshihiro Kakeji, Masaru Morita, Natsumi Yamashita, Yoshihiko Maehara

    Surgery today   40 ( 7 )   626 - 631   2010.7

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    DOI: 10.1007/s00595-009-4135-1

  • High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer Reviewed

    Kouji Andou, Yosihiro Kakeji, Hiroyuki Kitao, Makoto Iimori, Yan Zhao, Rintaro Yoshida, Eiji Oki, Keiji Yoshinaga, Takuya Matumoto, Masaru Morita, Yoshihisa Sakaguchi, Yoshihiko Maehara

    Cancer Science   101 ( 3 )   639 - 645   2010.3

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    DOI: 10.1111/j.1349-7006.2009.01457.x

  • The impact of a high-frequency microsatellite instability phenotype on the tumor location-related genetic differences in colorectal cancer Reviewed

    Yan Zhao, Eiji Oki, Kouji Andou, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

    Cancer Genetics and Cytogenetics   196 ( 2 )   133 - 139   2010.1

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    DOI: 10.1016/j.cancergencyto.2009.09.009

  • Salvage esophagectomy after definitive chemoradiotherapy for synchronous double cancers of the esophagus and head-and-neck Reviewed

    R. Yoshida, M. Morita, Kouji Andou, T. Masuda, Hiroshi Saeki, Eiji Oki, N. Sadanaga, T. Nakashima, Y. Kakeji, Yoshihiko Maehara

    Diseases of the Esophagus   23 ( 1 )   59 - 63   2010.1

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    DOI: 10.1111/j.1442-2050.2009.00973.x

  • Clinical features of primary small cell carcinoma of the thoracic esophagus A retrospective analysis of 12 surgically resected cases Reviewed

    Noriaki Sadanaga, Masaru Morita, Takanobu Masuda, Satoko Okada, Masahiko Sugiyama, Kouji Andou, Yoshihiro Kakeji, Hiroshi Matsuura, Yoshihiko Maehara

    Esophagus   6 ( 3 )   161 - 165   2009.9

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    DOI: 10.1007/s10388-009-0197-9

  • Chemosensitivity and survival in gastric cancer patients with microsatellite instability Reviewed

    Eiji Oki, Yoshihiro Kakeji, Yan Zhao, Rintaro Yoshida, Kouji Andou, Takanobu Masuda, Kippei Ohgaki, Masaru Morita, Yoshihiko Maehara

    Annals of Surgical Oncology   16 ( 9 )   2510 - 2515   2009.9

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    DOI: 10.1245/s10434-009-0580-8

  • Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer Reviewed

    Eiji Oki, Yan Zhao, Rintaro Yoshida, Takanobu Masuda, Kouji Andou, Masahiiko Sugiyama, Eriko Tokunaga, Masaru Morita, Yoshihiro Kakeji, Yoshihiko Maehara

    World Journal of Gastroenterology   15 ( 20 )   2520 - 2525   2009.5

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    DOI: 10.3748/wjg.15.2520

  • Two radically resected colorectal carcinoma cases with unresectable liver metastasis after adjuvant chemotherapy with bevacizumab Reviewed

    Masahiko Sugiyama, Yoshihiro Kakeji, Nobuhide Kubo, Tomonori Nakanoko, Yoshihiko Fujinaka, Kouji Andou, Takanobu Masuda, Kenji Yagi, Keishi Yoshinaga, Hiroshi Saeki, Kazuya Endo, Yasunori Emi, Masaru Morita, Yoshihiko Maehara

    Japanese Journal of Cancer and Chemotherapy   36 ( 12 )   2169 - 2171   2009.1

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  • Hepatic artery infusion chemotherapy to three liver metastasis cases in which systemic chemotherapy was impossible or ineffective Reviewed

    Kouji Andou, Eiji Oki, Yoshihiro Kakeji, Masahiko Sugiyama, Hiroshi Saeki, Kazuya Endo, Masaru Morita, Yasunori Emi, Yoshihiko Maehara

    Gan to kagaku ryoho. Cancer & chemotherapy   35 ( 12 )   2192 - 2194   2008.1

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  • High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer. Reviewed International journal

    Cancer Science   101 ( 3 )   639 - 645   1900

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  • Simultaneous resection of colorectal cancer and liver metastases in the right lobe using pure laparoscopic surgery. Reviewed International journal

    Surgery Today   44 ( 8 )   1588 - 1592   1900

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  • Mortalin is a prognostic factor of gastric cancer with normal p53 function. Reviewed International journal

    Gastric Cancer   17 ( 2 )   255 - 262   1900

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  • Secondary resistance of extra-gastrointestinal stromal tumors to imatinib mesylate: report of a case. International journal

    Surgery Today   41 ( 9 )   1290 - 1293   1900

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MISC

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Other

  • topoisomerase I 阻害剤に対する感受性バイオマーカーの開発

    2018.6

Research Projects

  • 血管新生阻害剤の臨床効果を予測する革新的コンパニオン診断薬の開発

    Grant number:24K11868  2024.4 - 2027.3

    科学研究費助成事業  基盤研究(C)

    安藤 幸滋, 中村 能章, 沖 英次, 吉住 朋晴

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    Grant type:Scientific research funding

    大腸癌治療の基本は手術による根治切除術であるが、切除不能進行・再発大腸癌の治療は殺細胞性抗がん剤及び分子標的薬を用いたがん薬物療法が中心となる。大腸癌治療における分子標的薬には血管新生阻害剤(ベバシズマブ、ラムシルマブ、アフリベルセプト)、抗EGFR抗体(セツキシマブ、パニツムマブ)などがある。抗EGFR抗体のコンパニオン診断薬はRAS遺伝子である。しかしながら、血管新生阻害剤には今のところ適切なコンパニオン診断薬がなく、どの分子標的薬を二次治療に用いるかは臨床医の判断となる。本研究では血管新生因子を中心に発現解析を行い、血管新生阻害剤の最適なコンパニオン診断薬探索を行う。

    CiNii Research

  • 血管新生阻害剤の臨床効果を予測する革新的コンパニオン診断薬の開発

    2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • Development of label free separation and recovery technology for circulating tumor cells

    Grant number:22H00591  2022.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (A)

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    CiNii Research

  • 高分子薬の有効化に寄与する癌微小環境改善薬の開発

    Grant number:21H04831  2021.4 - 2024.3

    科学研究費助成事業  基盤研究(A)

    山本 浩文, 安藤 幸滋, 中川 貴之, 赤井 周司, 横山 雄起, 森 正樹, 伊藤 心二, 江口 英利

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    Grant type:Scientific research funding

    日本人の死因のトップは癌であり、膵癌の5年生存率は6-7% しかない。最新医療の免疫チェックポイント阻害剤「オプジーボ」の奏効率は20%に留まり、CAR-T細胞療法「キムリア」は急性白血病や悪性リンパ腫に対しては著効するが、固形癌に対する効果は乏しい。固形癌の治療を困難にしているのは、癌細胞を取り巻く堅固な間質のバリアによって投与された薬の一部しか腫瘍細胞に到達しないという問題である。本研究課題では、これまでに開発してきたドラッグデリバリー技術を更に進化させ、癌の微小環境を改善する核酸医薬を確立する。その結果、抗体医薬、核酸医薬、細胞療法、ポリマー型抗癌剤 などの新しい医療の効果を高める。

    CiNii Research

  • バイオマーカーおよびプロテアソーム阻害剤を用いた新たなイリノテカン療法の開発

    Grant number:21K08735  2021 - 2023

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    安藤 幸滋, 沖 英次

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    Authorship:Principal investigator  Grant type:Scientific research funding

    TopoIの分解にはDNA-PKcs, Ku70, Ku80, BRCA1, BARD1の各分子が関わっていることを我々は発見した(Ando et al. Oncotarget, 2017)。このメカニズムの過程でtopoIセリン10残基のリン酸化が重要であることを見出し、この部位の抗体(topoI-pS10)を作成した。このtopoI-pS10抗体による免疫組織化学染色はイリノテカン感受性とよく相関することも見出した。また、topoI分解は最終的にユビキチンプロテアソーム経路により行われる。このため、この経路を阻害すれば、topoI阻害剤感受性をもたらすことができると考える。本研究ではこれら二つの発見を統合し、topoI阻害剤を用いたより効果的な治療法の探索及び開発を行う。

    CiNii Research

  • Innovative Therapies Targeting Increased Susceptibility to Chemoradiotherapy for Esophageal Cancer

    Grant number:20K09105  2020.4 - 2023.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Nakashima Yuichirou

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    1) Inhibition of Rad51 expression by siRNA in esophageal cancer cell lines improved sensitivity to cisplatin.2) Suppression of Rad51 expression by siRNA in esophageal cancer cell lines improved sensitivity to radiation.3) We focused on E2F1 as a factor that binds to the promoter region of Rad51, and treatment of the cell lines with Palbociclib, a CDK4/6 inhibitor, reduced Rad51 protein expression.(4) Treatment with Palbociclib in Rad51-high expressing cell lines increased sensitivity to cisplatin.

    CiNii Research

  • 消化器癌における効果的なイリノテカン療法を目指したバイオマーカーおよび新薬の開発

    Grant number:18K08683  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 消化器癌におけるtopoI阻害剤の作用増幅を目指した新規小分子化合物の探索と応用

    Grant number:17H06941  2017 - 2019

    日本学術振興会  科学研究費助成事業  研究活動スタート支援

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 消化器癌において用いられるイリノテカン感受性の新規バイオマーカーを探索する。 CPT-11はトポイソメラーゼI(Topo I)阻害剤であり、肺癌、大腸癌をはじめ多くの癌種に対する治療として用いられている。しかしながら、副作用として重篤な下痢が起きることもあり、CPT-11は適切な患者に用いることが重要である。本研究ではTopoIに着目し、CPT-11高感受性を表す新規バイオマーカーを探索することを目的とする。また、CPT-11に対して非感受性となるメカニズムについても検討し、CPT-11効果予測因子も検討する。本研究によりCPT-11の適切な使用が可能になると考えられ、 新たな治療法の確立も可能と考える。

    Grant number:26861082  2014 - 2015

    科学研究費助成事業  若手研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 消化管癌に対するイリノテカン療法の効果増強を目指した新たな治療法の開発

    Grant number:19K09219 

    佐伯 浩司, 安藤 幸滋, 沖 英次

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    Grant type:Scientific research funding

    本研究では、topoI分解の機序のさらなる解明に加え、topoI阻害剤の効果を上げる効果的な治療法の探索を行う。一方、プロトンポンプ阻害剤による化学療法の影響について様々な報告があるが、イリノテカンとプロトンポンプ阻害剤の関連についての報告は皆無である。topoI分解によるtopoI阻害剤耐性メカニズムをCTDSP1が阻害する可能性を見出しているが、そのCTDSP1はプロトンポンプ阻害剤の一つであるラベプラゾールによりその働きが阻害される 。CTDSP1のtopoI分解への関連性を証明することで、プロトンポンプ阻害剤のイリノテカン感受性への影響が解明できる。

    CiNii Research

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Other educational activity and Special note

  • 2018  Special Affairs 

Outline of Social Contribution and International Cooperation activities

  • 第60回国際外科学会においてYoung Investigator Awardを受賞した。

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Gastrointestinal Surgery

    大腸外科

Clinician qualification

  • Specialist

    Japan Surgical Society(JSS)

  • Specialist

    The Japanese Society of Gastroenterological Surgery

  • Preceptor

    The Japanese Society of Gastroenterological Surgery

  • Specialist

    日本消化器外科学会

Year of medical license acquisition

  • 2004

Notable Clinical Activities

  • 大腸癌の治療を行っております。手術から化学療法までトータルで診療に当たっております。