Updated on 2025/08/29

Information

 

写真a

 
ISEDA NORIFUMI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Assistant Professor
Title
Assistant Professor
Contact information
メールアドレス
Tel
0926425466

Degree

  • Doctor of Philosophy (Medical Science)

Research Interests・Research Keywords

  • Research theme: Examination of oxidative stress in hepatocellular carcinoma

    Keyword: hepatocellular carcinoma

    Research period: 2024.5

Awards

  • 第30回日本肝がん分子標的治療研究会 最優秀Award

    2025  

  • 第31回日本消化器癌発生学会総会 優秀演題賞

    2021.5  

  • 日本消化器癌発生学会 研究奨励賞

    2020.5  

  • 日本消化器病学会 専修医奨励賞

    2020.5  

Papers

  • Survival impact and recurrence prediction using oncologic resectability classification in hepatocellular carcinoma following hepatic resection: a Japanese multi‑center study Reviewed

    Norifumi Iseda· Shinji Itoh· Mizuki Ninomiya · Hiroto Kayashima · Takashi Motomura · Takuma Izumi · Takeo Toshima · Shohei Yoshiya · Yo‑Ichi Yamashita · Kengo Fukuzawa · Toru Utsunomiya · Shoichi Inokuchi Takashi Maeda · Eiji Tsujita · Kazutoyo Morita · Hidefumi Higashi · Keishi Sugimachi · Takahiro Tomino · Ryosuke Minagawa · Koichi Kimura · Hideaki Uchiyama · Noboru Harada · Tomoharu Yoshizumi

    International Journal of Clinical Oncology   2025.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Differences in Tumor-Infiltrating Lymphocyte Counts in the Peritumoral Area in Patients Undergoing Hepatic Resection After Lenvatinib and Atezolizumab Plus Bevacizumab Therapy for Hepatocellular Carcinoma Reviewed

    Katsuya Toshida , Shinji Itoh , Yasushi Tanaka , Takeo Toshima , Shohei Yoshiya , Takuma Izumi , Norifumi Iseda , Yuriko Tsutsui , Yuki Nakayama , Takuma Ishikawa , Mizuki Ninomiya , Takeshi Iwasaki , Yoshinao Oda , Tomoharu Yoshizumi 

    Cancer medicine   2025.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Successful Hepatectomy for a Liver Abscess With Portal Vein Thrombus and Hepatic Artery Dissection: A Case Report Reviewed

    Norifumi Iseda , Tomohiro Iguchi , Seiya Kato , Noriaki Sadanaga , Hiroshi Matsuura

    Cureus   2025.2

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Clinical validation of preoperative serum markers for liver fibrosis in living donor liver transplantation recipients Reviewed

    Takahiro Tomino, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Norifumi Iseda, Takuma Izumi, Yuriko Tsutsui, Katsuya Toshida, Tomoharu Yoshizumi

    Surgery Today   2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Novel protocol for prevention from hepatitis B reactivation following living-donor liver transplantation Reviewed

    Takuma Izumi, Takeo Toshima, Shinji Itoh, Shohei Yoshiya, Yuki Bekki, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi

    Hepatology Research    2024.9

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Outcome of hepatectomy after systemic therapy for hepatocellular carcinoma: a Japanese multicenter study Reviewed

    Norifumi Iseda · Shinji Itoh· Takeo Toshima· Shohei Yoshiya· Yuki Bekki· Yuriko Tsutsui· Katsuya Toshida· Shoichi Inokuchi· Toru Utsunomiya· Takahiro Tomino· Keishi Sugimachi· Kazutoyo Morita· Mizuki Ninomiya· Noboru Harada· Ryosuke Minagawa· Tomoharu Yoshizumi

    Surgery Today   2024.8

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • The Association of Transferrin Receptor with Prognosis and Biologic Role in Intrahepatic Cholangiocarcinoma Reviewed

    Katsuya Toshida #, Shinji Itoh #, Norifumi Iseda, Takuma Izumi, Yuki Bekki, Shohei Yoshiya, Takeo Toshima, Takeshi Iwasaki, Yoshinao Oda, Tomoharu Yoshizumi

    Annals of Surgical Oncology   2024.8

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  • The impact of perioperative synbiotics treatment in living-donor liver transplantation after induction of early enteral nutrition Reviewed

    Shohei Yoshiya, Shinji Itoh, Takeo Toshima, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi

    Surgery Today   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The Impact of TP53-Induced Glycolysis and Apoptosis Regulator on Prognosis in Hepatocellular Carcinoma: Association with Tumor Microenvironment and Ferroptosis Reviewed

    Katsuya Toshida , Shinji Itoh , Norifumi Iseda , Shugo Tanaka , Kensuke Nakazono , Takahiro Tomiyama , Shohei Yoshiya , Takeo Toshima , Noboru Harada , Kenichi Kohashi , Koji Taniguchi , Yoshinao Oda , Tomoharu Yoshizumi 

    Liver cancer   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Association of serum lactate dehydrogenase with prognosis and tumor metabolism in patients with hepatocellular carcinoma treated with atezolizumab plus bevacizumab therapy Reviewed

    Katsuya Toshida, Shinji Itoh, Takeo Toshima, Shohei Yoshiya, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuki Nakayama, Takuma Ishikawa, Tomoharu Yoshizumi

    Surgery Today   2024.8

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Impact of albumin-lymphocyte-platelet-C-reactive protein index as a prognostic indicator of hepatocellular carcinoma after resection: Associated with nuclear factor erythroid 2-related factor 2 Reviewed International journal

    Norifumi Iseda, Shinji Itoh, Katsuya Toshida, Yuuki Nakayama, Takuma Ishikawa, Yuriko Tsutsui, Takuma Izumi, Yuki Bekki, Shohei Yoshiya, Takeo Toshima, Tomoharu Yoshizumi

    Hepatology Research    2024.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Is preoperative weight reduction of living-donor liver transplant recipients and donors harmful to postoperative outcomes? Reviewed

    Shohei Yoshiya, Shinji Itoh, Takeo Toshima, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Yasushi Tanaka, Mizuki Ninomiya, Tomoharu Yoshizumi

    Journal of Gastrointestinal Surgery   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Impact of electrical muscle stimulation on serum myostatin level and maintenance of skeletal muscle mass in patients undergoing living-donor liver transplantation: Single-center controlled trial Reviewed

    Yuriko Tsutsui, Shinji Itoh, Takeo Toshima, Sachiyo Yoshio, Shohei Yoshiya, Takuma Izumi, Norifumi Iseda, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Yukiko Kosai-Fujimoto, Kazuki Takeishi, Tomoharu Yoshizumi

    Hepatology Research    2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Impact of ACSL4 on the prognosis of hepatocellular carcinoma: Association with cancer-associated fibroblasts and the tumour immune microenvironment Reviewed

    Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takahiro Tomiyama, Shohei Yoshiya, Takeo Toshima, Yu-Chen Liu, Takeshi Iwasaki, Daisuke Okuzaki, Koji Taniguchi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

    Liver International   2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • What is the crux of successful living-donor liver transplantation for recipients aged 70 and beyond? Reviewed

    Takeo Toshima, Shinji Itoh, Yoshihiro Nagao, Shohei Yoshiya, Yuki Bekki, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Tomoharu Yoshizumi

    Annals of Gastroenterological Surgery    2024.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Pretreatment eosinophil count predicts response to atezolizumab plus bevacizumab therapy in patients with hepatocellular carcinoma Reviewed

    Katsuya Toshida, Shinji Itoh, Shohei Yoshiya, Yoshihiro Nagao, Takahiro Tomino, Takuma Izumi, Norifumi Iseda, Takeo Toshima, Mizuki Ninomiya, Tomoharu Yoshizumi 

    Journal of Gastroenterology and Hepatology   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Association of gut microbiota with portal vein pressure in patients with liver cirrhosis undergoing living donor liver transplantation Reviewed

    Katsuya Toshida, Shinji Itoh, Yukiko Kosai-Fujimoto, Takuma Ishikawa, Yuki Nakayama, Yuriko Tsutsui, Norifumi Iseda, Takuma Izumi, Yuki Bekki, Shohei Yoshiya, Takeo Toshima, Makoto Nakamuta, Tomoharu Yoshizumi 

    JGH Open    2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Hand-assisted laparoscopic splenectomy and gastropancreatic fold division: a less-invasive simplified technique of Hassab's procedure for refractory esophagogastric varices Reviewed

    Hitoshi Iwasaki, Mizuki Ninomiya, Shinji Itoh, Kazuki Takeishi, Hidefumi Higashi, Norifumi Iseda, Takuma Izumi, Shohei Yoshiya, Takeo Toshima, Tomoharu Yoshizumi 

    Surgery Today   2023.12

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Impact of TP53-induced glycolysis and apoptosis regulator on malignant activity and resistance to ferroptosis in intrahepatic cholangiocarcinoma Reviewed

    Katsuya Toshida, Shinji Itoh, Norifumi Iseda, Takuma Izumi, Shohei Yoshiya, Takeo Toshima, Mizuki Ninomiya, Takeshi Iwasaki, Yoshinao Oda, Tomoharu Yoshizumi

    Cancer Science   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Development of predictive score for postoperative dysphagia after emergency abdominal surgery in patients of advanced age Reviewed

    Tomohiro Iguchi, Junya Mita, Norifumi Iseda, Shun Sasaki, Noboru Harada, Mizuki Ninomiya, Keishi Sugimachi, Takuya Honboh, Noriaki Sadanaga, Hiroshi Matsuura

    Annals of Gastroenterological surgery   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Textbook outcome in the laparoscopic cholecystectomy of acute cholecystitis Reviewed International journal

    Norifumi Iseda, Tomohiro Iguchi, Shinji Itoh, Shun Sasaki, Takuya Honboh, Tomoharu Yoshizumi, Noriaki Sadanaga , Hiroshi Matsuura 

    Asian Journal of Endoscopic Surgery   2023.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Prognostic Impact of Lymphocyte-to-C-Reactive Protein Ratio in Patients Who Underwent Surgical Resection for Pancreatic Cancer Invited Reviewed International journal

    Norifumi Iseda, Tomohiro Iguchi, Kosuke Hirose, Shinji Itoh, Takuya Honboh, Noriaki Sadanaga, Hiroshi Matsuura

    The American surgeon   2023.5

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  • Safety of laparoscopic cholecystectomy in patients with a cerebrospinal fluid shunt in the peritoneal cavity Reviewed

    Daichi Inaba, Tomohiro Iguchi, Norifumi Iseda, Shun Sasaki, Takuya Honboh, Akira Okura, Noriaki Sadanaga, Hiroshi Matsuura

    Asian Journal of Endoscopic Surgery   2023.4

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  • Clinical Significance of Signal Regulatory Protein Alpha (SIRPα) Expression in Hepatocellular Carcinoma Reviewed

    Takahiro Tomiyama, Shinji Itoh, Norifumi Iseda, Katsuya Toshida, Yukiko Kosai-Fujimoto, Takahiro Tomino, Takeshi Kurihara, Yoshihiro Nagao, Kazutoyo Morita, Noboru Harada, Yu-Chen Liu, Daisuke Ozaki, Kenichi Kohashi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

    Annals of Surgical Oncology    2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor‐4 inhibition in hepatocellular carcinoma Reviewed International journal

    Norifumi Iseda, Shinji Itoh, Katsuya Toshida, Takahiro Tomiyama,Akinari Morinaga, Masahiro Shimokawa, Tomonari Shimagaki, Huanlin Wang,Takeshi Kurihara, Takeo Toshima, Yoshihiro Nagao, Noboru Harada,Tomoharu Yoshizumi, Masaki Mori

    Cancer Science   2022.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

  • Impact of Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocellular Carcinoma: Cancer Metabolism and Immune Status Reviewed International journal

    Norifumi Iseda , Shinji Itoh , Tomoharu Yoshizumi, Takahiro Tomiyama, Akinari Morinaga, Kyohei Yugawa , Masahiro Shimokawa, Tomonari Shimagaki, Huanlin Wang, Takeshi Kurihara , Yoshiyuki Kitamura, Yoshihiro Nagao, Takeo Toshima , Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, and Masaki Mori

    Hepatology Communications    2022.5

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Prognostic Impact of the Preoperative Systemic Inflammation Score in Patients With Pancreatic Ductal Adenocarcinoma Reviewed

    Tomohiro Iguchi, Norifumi Iseda, Kosuke Hirose, Shinji Itoh, Noboru Harada, Mizuki Ninomiya, Keishi Sugimachi, Takuya Honboh, Takashi Maeda, Noriaki Sadanaga, and Hiroshi Matsuura 

    The American surgeon   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

  • The ratio of serum des‐gamma‐carboxy prothrombin to tumor volume as a new biomarker for early recurrence of resected hepatocellular carcinoma Reviewed

    Tomonari Shimagaki, Tomoharu Yoshizumi, Shinji Itoh,Norifumi Iseda, Takahiro Tomiyama, Akinari Morinaga, Huanlin Wang,Takeshi Kurihara, Yoshihiro Nagao, Takeo Toshima, Noboru Harada, Nao Kinjo, Takashi Maeda, Masaki Mor

    2022.2

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  • Myeloid‑derived suppressor cell infiltration is associated with a poor prognosis in patients with hepatocellular carcinoma Reviewed

    Takahiro Tomiyama, Shinji Itoh, Norifumi Iseda, Katuya Toshida, Akinari Morinaga, Kyohei Yugawa, Yukiko Kosai Fujimoto, Takahiro Tomino, Takeshi Kurihara, Yoshihiro Nagao, Kazutoyo Morita, Noboru Harada, Kenichi Kohashi, Yoshinao Oda, Masaki Mori, Tomoharu Yoshizumi

    2022.1

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    Language:English  

  • Lymphocyte‐to‐C‐reactive protein ratio as a prognostic factor for hepatocellular carcinoma Reviewed International journal

    Norifumi Iseda · Shinji Itoh · Tomoharu Yoshizumi · Takahiro Tomiyama · Akinari Morinaga · Tomonari Shimagaki · Huanlin Wang · Takeshi Kurihara · Takeo Toshima · Yoshihiro Nagao · Noboru Harada · Yoshinao Oda · Masaki Mori

    International Journal of Clinical Oncology    2021.6

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    Authorship:Lead author   Language:Japanese   Publishing type:Research paper (scientific journal)  

  • ARID1A Deficiency Is Associated With High Programmed Death Ligand 1 Expression in Hepatocellular Carcinoma Reviewed International journal

    Norifumi Iseda , Shinji Itoh , Tomoharu Yoshizumi, Kyohei Yugawa , Akinari Morinaga, Takahiro Tomiyama, Takeo Toshima, Kenichi Kohashi, Yoshinao Oda, and Masaki Mori

    Hepatology Communications    2021.5

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  • Hemophagocytic syndrome after living donor liver transplantation: a case report with a review of the literature Reviewed International journal

    Norifumi Iseda, Tomoharu Yoshizumi, Takeo Toshima, Akinari Morinaga, Takahiro Tomiyama, Junichi Takahashi, Takashi Motomura, Yohei Mano, Shinji Itoh, Noboru Harada, Toru Ikegami and Yuji Soejima

    Surgical Case Reports    2018.5

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

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Presentations

  • 肝細胞癌における非解剖学的切除と解剖学的切除の検討

    伊勢田憲史、伊藤心二、戸島剛男、吉屋匠平、別城悠樹、泉琢磨、筒井由梨子、吉住朋晴

    第124回 日本外科学会・定期学術集会  2024.4 

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    Event date: 2024.4

    Language:Japanese  

    Country:Japan  

    【背景】 肝細胞癌は脈管を介し転移する事が多く、解剖学的切除術(AR)が普及したが、非解剖学的切除術(NAR)と比較した解剖学的切除術の優位性について、議論の余地がある。今回の目的は脈管浸潤のない単発、肝細胞癌患者でAR、NARの長期成績を含めた手術成績を明らかにする事である。
    【方法】
    検討1. 2002年1月から2019年12月に単発の肝細胞癌患者に手術を施行した303例で、病理学的脈管浸潤(mvi)、肝内転移(im)の予測因子を検討した。
    検討2. 検討1の結果を元にmvi、imがないと予想される単発、5cm以下の肝細胞癌症例を対象としNAR群、AR群で患者背景、手術所見、術後経過、術後合併症、病理組織学的所見、予後を検討した。
    検討3 検討2の対象症例で2群間の背景因子をマッチングした後に検討した。
    検討4. 腫瘍径が0-2cm群、2.1-5.0cm群でサブグループ解析を施行した。
    【結果】
    結果1. 303例よりmvi、imを予測する因子は、DCP>146 (mAU/ml)(P=0.002)であった。
    結果2. 対象症例176例中71例(40.3%)に対してARが施行された。AR群で、BMIが低く(p=0.028)、血清アルブミン値が高く(p=0.004)、腫瘍径が大きく(p<0.001)、F3/4が少なく(p=0.012)、手術時間が長く(p<0.001)、出血量が多く(p=0.031)、入院期間が長く(p=0.001)、術後合併症が多かった(p=0.018)。再発形式、無再発生存期間(RFS)、全生存期間(OS)に差を認めなかった。
    結果3. AR群とNAR群ともに42例で、RFS、OSは同等であった。
    結果4. 腫瘍径が0-2cm群、2.1-5.0cm群の症例はそれぞれ75例(42.6%)、101例(57.4%)であり19例(25.3%)、52例(51.5%)に対してARが施行された。NAR群と比較してRFS、OSに差を認めなかった。
    【まとめ】 mvi、imがないと予想される単発5cm以下の肝細胞癌においてはARとNARの再発形式、長期成績を含めた術後成績は同等であり、残肝機能を考慮した手術選択が推奨される可能性が示唆された。

Research Projects

  • 新規エピジェネティック制御ヒストンラクチル化の肝細胞癌治療応用の検討

    2024 - 2026

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Early-Career Scientists

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    Grant type:Scientific research funding

Educational Activities

  • 各週にローテンションしてくるポリクリ、クリクラの学生に担当症例を振り当て術前の状態の確認、プレゼン、手術、術後管理に関して指導をする。

Clinician qualification

  • 高度技能専門医

    Japanese Society of Hepato-Biliary-Pancreatic Surgery

  • Specialist

    The Japanese Society of Gastroenterological Surgery

  • Specialist

    The Japanese Society of Gastroenterology(JSGE)

  • Specialist

    Japan Surgical Society(JSS)