Updated on 2024/06/10

Information

 

写真a

 
MITOMA HIROKI
 
Organization
Beppu Hospital Department of Internal Medicine Associate Professor
Title
Associate Professor
Profile
Role of innate immune systems in autoimmune diseases
Homepage
External link

Degree

  • Doctor of Philosophy

  • Medical Doctor

Research History

  • 2002年4月～2003年3月　国立病院機構福岡病院　内科医師   

    2002年4月～2003年3月　国立病院機構福岡病院　内科医師

  • 2010年3月～2012年3月　University of Texas, MD Anderson Cancer Center　研究員 2012年3月～2014年3月　Baylor University Medical Center　研究員   

Research Interests・Research Keywords

  • Research theme： Action of a novel TNF inhibitor (nanobody) on TNF-expressing cells

    Keyword： apoptosis, reverse signal, MAP kinase

    Research period： 2023.4 - 2025.3

  • Research theme： Suppressive ablilites of regulatory T cells for Tph cells

    Keyword： Tph cells, regulatory T cells, rhumatoid arthritis, systemic sclerosis

    Research period： 2020.4 - 2025.3

  • Research theme： Analysis of mechanisms of vascular endothelial injury in systemic sclerosis

    Keyword： vascular endothelial injury, systemic sclerosis

    Research period： 2020.4 - 2023.3

  • Research theme： The role of M2 macrophages in the pathogenesis of systemic sclerosis

    Keyword： Systemic sclerosis, M2 macrophages, fibrosis

    Research period： 2018.5 - 2021.3

  • Research theme： Analysis of inflammasome in Adult onset Still's disease

    Keyword： inflammasome, AOSD

    Research period： 2018.4 - 2021.3

  • Research theme： Functional analysis of anti-TNF agents for Fc receptor-expressing cells in rheumatoid arthritis

    Keyword： anti-TNF agents, Fc receptor, Macrophages, synovial fibroblasts, rheumatoid arthritis

    Research period： 2016.10 - 2018.3

  • Research theme： Role of TNF-R2 signaling in human follicular regulatory T cells.

    Keyword： Follicular regulatory T cells, B cells, Tumor necrosis factor, Receptors for Tumor necrosis factor-alpha, Follicular T cells

    Research period： 2016.4 - 2021.10

  • Research theme： How self nucleic acids activate innate immune systems in innate immune systems

    Keyword： autoimmune diseases, self nucleic acids, innate immunity, plasmacytoid dendritic cells, macrophages

    Research period： 2014.4 - 2018.3

Awards

  • 塩川美奈子・膠原病研究奨励賞

    2021.4   日本リウマチ財団  

  • 学会賞（奨励賞）

    2014.4   日本リウマチ学会  

Papers

  • Recent advances in the treatment strategy for AAV improved outcomes with intensive GC tapering Reviewed International journal

    @Ono N, Kai T, Takeyama Y, Inoue Y, Ueda N, Nagano S, Ohta S, Inoue H, Sawabe T, Chifu Y, Yoshizawa S, Oryoji K, @Kimoto Y, Miyake K, @Ayano M, @Mitoma H, @Arinobu Y, Miyamura T, @Horiuchi T, @Akashi K, Tada Y, @Niiro H

    Int J Rheum Dis.   27 ( 1 )   e15009   2024.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis. Reviewed International journal

    #Sagawa F, @Yamada H, @Ayano M, @Kimoto Y, @Mitoma H, @Ono N, @Arinobu Y, Kondo M, @Nakashima Y, @Akashi K, @Horiuchi T, @Niiro H

    RMD Open   10 ( 1 )   e003693   2024.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/rmdopen-2023-003693

  • Immunosuppressive therapy and humoral response to third mRNA COVID-19 vaccination with a six-month interval in rheumatic disease patients Invited Reviewed International journal

    @Yusuke Kashiwado, @Yasutaka Kimoto, Shiro Ohshima, Takuya Sawabe, Kensuke Irino, Shota Nakano, @Junki Hiura, @Akiko Yonekawa, Qiaolei Wang, @Goro Doi, @Masahiro Ayano, @Hiroki Mitoma, @Nobuyuki Ono, @Yojiro Arinobu, @Hiroaki Niiro, Taeko Hotta, Dongchon Kang, @Nobuyuki Shimono, @Koichi Akashi, Tsutomu Takeuchi, @Takahiko Horiuchi

    Rheumatology (Oxford)   2023.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/rheumatology/kead275

  • Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus Invited Reviewed International journal

    #Fujimoto, Sho; @Arinobu, Yojiro; @Miyawaki, Kohta; @Ayano, Masahiro; @Mitoma, Hiroki; @Kimoto, Yasutaka; @Ono, Nobuyuki; @Akashi, Koichi; @Horiuchi, Takahiko; @Niiro, Hiroaki

    RHEUMATOLOGY   2023.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/rheumatology/kead082

  • CEACAM 1, 3, 5 and 6-positive classical monocytes correlate with interstitial lung disease in early systemic sclerosis Invited Reviewed International journal

    #Yokoyama, Kana; @Mitoma, Hiroki; @Kawano, Shotaro; @Yamauchi, Yusuke; Wang, Qiaolei; @Ayano, Masahiro; @Kimoto, Yasutaka; @Ono, Nobuyuki; @Arinobu, Yojiro; @Akashi, Koichi; @Horiuchi, Takahiko; @Niiro, Hiroaki

    FRONTIERS IN IMMUNOLOGY   13   2022.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2022.1016914

  • Safety and efficacy of switching immunosuppressive drugs for maintenance treatment in patients with systemic lupus erythematosus: A retrospective cohort study Invited Reviewed International journal

    @Ayano, Masahiro; @Kimoto, Yasutaka; @Mitoma, Hiroki; Akahoshi, Mitsuteru; @Ono, Nobuyuki; @Arinobu, Yojiro; @Akashi, Koichi; @Horiuchi, Takahiko; @Niiro, Hiroaki

    MODERN RHEUMATOLOGY   2022.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/mr/roac100

  • Comparative efficacy and safety of mizoribine and mycophenolate mofetil for treating systemic lupus erythematosus: a retrospective cohort study Invited Reviewed International journal

    @Masahiro Ayano, @Yasutaka Kimoto, @Hiroki Mitoma, Mitsuteru Akahoshi, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE   14   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/1759720X221096367

  • Comparative efficacy and safety of mizoribine and mycophenolate mofetil for treating systemic lupus erythematosus: a retrospective cohort study Invited Reviewed International journal

    @Masahiro Ayano, @Yasutaka Kimoto, @Hiroki Mitoma, Mitsuteru Akahoshi, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE   14   2022.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/1759720X221096367

  • Antibody response to SARS-CoV-2 mRNA vaccines in patients with rheumatic diseases in Japan: Interim analysis of a multicentre cohort study Invited Reviewed International journal

    @Yusuke Kashiwado, @Yasutaka Kimoto, Takuya Sawabe, Kensuke Irino, Shota Nakano, Junki Hiura, Qiaolei Wang, Shotaro Kawano, @Masahiro Ayano, @Hiroki Mitoma,@ Nobuyuki Ono, @Yojiro Arinobu, @Hiroaki Niiro, Taeko Hotta, Dongchon Kang, @Koichi Akashi, Shiro Ohshima, Tsutomu Takeuchi, and Takahiko Horiuchi

    MODERN RHEUMATOLOGY   2022.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/mr/roac030

  • TNFR2 Signaling Enhances Suppressive Abilities of Human Circulating T Follicular Regulatory Cells Invited Reviewed International journal

    #Shotaro Kawano, @Hiroki Mitoma, Shoichiro Inokuchi, #Yusuke Yamauchi, #Kana Yokoyama, Jumpei Nogami, @Yuichiro Semba, @Masahiro Ayano, @Yasutaka Kimoto, Mitsuteru Akahoshi, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi and @Hiroaki Niiro

    JOURNAL OF IMMUNOLOGY   208 ( 5 )   1057 - 1065   2022.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.2100323

  • Hydroxychloroquine versus tacrolimus for the treatment of persistently active systemic lupus erythematosus Invited Reviewed International journal

    #Masahiro Ayano, #Yasutaka Kimoto, #Hiroki Mitoma, Mitsuteru Akahoshi, #Nobuyuki Ono, #Yojiro Arinobu, #Koichi Akashi, #Takahiko Horiuchi, #Hiroaki Niiro

    MODERN RHEUMATOLOGY   32 ( 2 )   345 - 350   2022.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/mr/roab010

  • Predictive factors of fetal and maternal pregnancy outcomes in Japanese patients with systemic lupus erythematosus Invited Reviewed International journal

    Kensuke Irino, @Yojiro Arinobu, @Masahiro Ayano, Shotaro Kawano, @Yasutaka Kimoto, @Hiroki Mitoma, @Mitsuteru Akahoshi, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    LUPUS   30 ( 10 )   1637 - 1643   2021.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1177/09612033211031989

  • HLA-B52 allele in giant cell arteritis may indicate diffuse large-vessel vasculitis formation: a retrospective study Invited Reviewed International journal

    #Kazuo Kushimoto, @Masahiro Ayano, Keisuke Nishimura, #Miki Nakano, @Yasutaka Kimoto, @Hiroki Mitoma, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi & @Hiroaki Niiro

    ARTHRITIS RESEARCH & THERAPY   23 ( 1 )   2021.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13075-021-02618-4

  • Association of elevated serum soluble CD226 levels with the disease activity and flares of systemic lupus erythematosus. Reviewed International journal

    #Miki Nakano, @Masahiro Ayano, #Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, @Hiroki Mitoma, @Yasutaka Kimoto, Mitsuteru Akahoshi, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi & @Hiroaki Niiro

    Scientific reports   11 ( 1 )   16162 - 16162   2021.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-021-95711-2

  • Increased Proportion of CD226(+) B Cells Is Associated With the Disease Activity and Prognosis of Systemic Lupus Erythematosus Invited Reviewed International journal

    #Miki Nakano, @Masahiro Ayano, #Kazuo Kushimoto, Shotaro Kawano, Kazuhiko Higashioka, Shoichiro Inokuchi, @Hiroki Mitoma, @Yasutaka Kimoto, Mitsuteru Akahoshi, @Nobuyuki Ono, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi, and @Hiroaki Niiro

    FRONTIERS IN IMMUNOLOGY   12   2021.7

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2021.713225

  • Activation of caspase-1 is mediated by stimulation of interferon genes and NLR family pyrin domain containing 3 in monocytes of active systemic lupus erythematosus Reviewed International journal

    #Shoichiro Inokuchi, @Hiroki Mitoma, #Shotaro Kawano, @Masahiro Ayano, @Yasutaka Kimoto, Mitsuteru Akahoshi, @Yojiro Arinobu, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    Clin Exp Rheumatol   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Human PD-1(hi)CD8(+) T Cells Are a Cellular Source of IL-21 in Rheumatoid Arthritis Invited Reviewed International journal

    Kazuhiko Higashioka, #Motoki Yoshimura, Takahide Sakuragi, @Masahiro Ayano, @Yasutaka Kimoto, @Hiroki Mitoma, @Nobuyuki Ono, @Yojiro Arinobu, Makoto Kikukawa, Hisakata Yamada, @Takahiko Horiuchi, @Koichi Akashi, @Hiroaki Niiro

    FRONTIERS IN IMMUNOLOGY   12   2021.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2021.654623

  • Type 1 helper T cells generate CXCL9/10-producing T-bet(+) effector B cells potentially involved in the pathogenesis of rheumatoid arthritis Invited Reviewed International journal

    Tsuyoshi Nakayama, Motoki Yoshimura, Kazuhiko Higashioka, Kohta Miyawaki, Yuri Ota, @Masahiro Ayano, @Yasutaka Kimoto, @Hiroki Mitoma, @Nobuyuki Ono, @Yojiro Arinobu, @Makoto Kikukawa, Hisakata Yamada, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    CELLULAR IMMUNOLOGY   360   2021.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.cellimm.2020.104263

  • Generation of a novel CD30(+)B cell subset producing GM-CSF and its possible link to the pathogenesis of systemic sclerosis Invited Reviewed International journal

    Kazuhiko Higashioka, Yoshikane Kikushige, Masahiro Ayano, Yasutaka Kimoto, Hiroki Mitoma, Makoto Kikukawa, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Koichi Akashi, and Hiroaki Niiro

    MODERN RHEUMATOLOGY   201 ( 3 )   233 - 243   2020.9

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/cei.13477

  • Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents Invited Reviewed International journal

    Qiaolei Wang, Daisuke Oryoji, @Hiroki Mitoma, @Yasutaka Kimoto, Masamichi Koyanagi, Kana Yokoyama, @Masahiro Ayano, Mitsuteru Akahoshi, @Yojiro Arinobu, @Hiroaki Niiro, @Koichi Akashi, @Takahiko Horiuchi

    FRONTIERS IN IMMUNOLOGY   11   2020.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2020.02042

  • Association of circulating SLAMF7(+)Tfh1 cells with IgG4 levels in patients with IgG4-related disease Invited Reviewed International journal

    Kazuhiko Higashioka, Yuri Ota, Takashi Maehara, Masafumi Moriyama, Masahiro Ayano, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Takahiko Horiuchi, Seiji Nakamura, Koichi Akashi, and Hiroaki Niiro

    BMC IMMUNOLOGY   21 ( 1 )   2020.6

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s12865-020-00361-0

  • Homeostatic milieu induces production of deoxyribonuclease 1-like 3 from myeloid cells Invited Reviewed International journal

    #Shoichiro Inokuchi, @Hiroki Mitoma, @Shotaro Kawano, @Shota Nakano, @Masahiro Ayano, @Yasutaka Kimoto, @Mitsuteru Akahoshi, @Yojiro Arinobu, @Hiroshi Tsukamoto, @Koichi Akashi, @Takahiko Horiuchi, @Hiroaki Niiro

    Journal of Immunology   204 ( 8 )   2088 - 2097   2020.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1901304

  • Effects of tumor necrosis factor inhibitors and tocilizumab on the glycosylated hemoglobin levels in patients with rheumatoid arthritis; an observational study Reviewed International journal

    #Otsuka Y, @Kiyohara C, #Kashiwado Y, Sawabe T, Nagano S, Kimoto Y, @Ayano M, @Mitoma H, @Akahoshi M, @Arinobu Y, @Niiro H, @Akashi K, @Horiuchi T

    PLOS ONE   13 ( 4 )   2018.4

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1371/journal.pone.0196368

  • Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer Reviewed International journal

    Okugawa Y, Toiyama Y, Toden S, Hiroki Mitoma, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A

    Gut   66 ( 1 )   107 - 117   2017.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1136/gutjnl-2015-309359

  • Functional interleukin-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Reviewed

    Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, Shun Ichiro Ota, Yuri Ota, Hiroki Mitoma, Mitsuteru Akahoshi, Yasuo Mori, Hiromi Iwasaki, Hiroaki Niiro, Hiroshi Tsukamoto, Koichi Akashi

    Immunology   150 ( 1 )   64 - 73   2017.1

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Interleukin-33 (IL-33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity-mediated allergic inflammation. Allergy-related innate myeloid cells such as eosinophils, basophils and mast cells express the IL-33 receptor (IL-33R), but it is still unknown how IL-33 regulates allergic inflammation involving these cells and their progenitors. Here, we revealed that the functional IL-33R was expressed on eosinophil progenitors (EoPs), basophil progenitors (BaPs) and mast cell progenitors (MCPs). In the presence of IL-33, these progenitors did not expand, but produced a high amount of Th2 and pro-inflammatory cytokines such as IL-9, IL-13, IL-1β and IL-6. The amount of cytokines produced by these progenitors was greater than that by mature cells. In vivo, IL-33 stimulated the expansion of EoPs, but it was dependent upon the elevated serum IL-5 that is presumably derived from type 2 innate lymphoid cells that express functional IL-33R. These data collectively suggest that EoPs, BaPs and MCPs are not only the sources of allergy-related granulocytes, but can also be sources of allergy-related cytokines in IL-33-induced inflammation. Because such progenitors can differentiate into mature granulocytes at the site of inflammation, they are potential therapeutic targets in IL-33-related allergic diseases.

    DOI： 10.1111/imm.12667

  • Quality of life in Japanese female patients with systemic lupus erythematosus Evaluation using the Short Form 36 Health Survey Reviewed

    Makio Furukawa, Chikako Kiyohara, Takahiko Horiuchi, Hiroshi Tsukamoto, Hiroki Mitoma, yasutaka kimoto, Ayumi Uchino, Misato Nakagawa, Kensuke Oryoji, Terufumi Shimoda, Koichi Akashi

    Modern Rheumatology   26 ( 2 )   240 - 247   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    Objective. Aspects of health-related quality of life (HRQoL) are important for assessing perceived health status and treatment burden. We evaluated HRQoL using Short Form 36 Health Survey (SF-36) and factors associated with HRQoL. Methods. We collected basic and lifestyle-related, clinical, and treatment characteristics among 119 female Japanese patients with systemic lupus erythematosus (SLE). Odds ratios (ORs) and their 95% confidence intervals were assessed for associations between HRQoL and selected factors. Results. Irregularity of sleep was significantly associated with risk of lower role physical (RP) (OR = 8.27), vitality (VT) (OR = 8.45), and role emotional (OR = 10.7) domains. Compared with clerical work, non-clerical work was significantly associated with risk of lower RP (OR = 7.39), and unemployment was significantly associated with risk of lower VT (OR = 41.0). Daily soybean intake was associated with improved General Health or GH (OR = 0.17). Compared with Systemic Lupus Collaborative Clinics Damage Index (SDI) = 0, SDI > 2 was associated with risk of lower PF (OR = 7.88), RP (OR = 4.29), and bodily pain (OR = 3.06) domains. Conclusion. Reduced HRQoL was observed in our SLE patients. Interventions addressing sleep and work disturbances, as well as daily soybean consumption, could alter the HRQoL of SLE patients.

    DOI： 10.3109/14397595.2015.1060668

  • Quality of life in Japanese female patients with systemic lupus erythematosus: Evaluation using the Short Form 36 Health Survey. Reviewed International journal

    Furukawa M, Kiyohara C, Takahiko Horiuchi, Tsukamoto H, Hiroki Mitoma, Yasutaka Kimoto, Uchino A, Nakagawa M, Oryoji K, Shimoda T, koichi akashi

    Mod Rheumatol.   26 ( 2 )   240 - 247   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

  • Generation mechanism of RANKL(+) effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis Invited Reviewed International journal

    Ota, Yuri, Hiroaki Niiro, Ota S, Ueki N, Tsuzuki H, Nakayama T, Mishima K, Higashioka K, Siamak JT, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Kukita A, Yamada H, Tsukamoto H, koichi akashi

    ARTHRITIS RESEARCH & THERAPY   18   2016.3

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13075-016-0957-6

  • Increased CD226 Expression on CD8(+) T Cells Is Associated with Upregulated Cytokine Production and Endothelial Cell Injury in Patients with Systemic Sclerosis Invited Reviewed International journal

    Ayano, Masahiro, Tsukamoto H, Kohno K, Ueda N, Tanaka A, Hiroki Mitoma, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Takahiko Horiuchi, koichi akashi

    JOURNAL OF IMMUNOLOGY   195 ( 3 )   892 - 900   2015.8

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1403046

  • Serum progranulin levels are elevated in dermatomyositis patients with acute interstitial lung disease, predicting prognosis Reviewed International journal

    Tanaka, Atsushi, Hiroshi Tsukamoto, Hiroki Mitoma, Chikako Kiyohara, Ueda, Naoyasu, Ayano, Masahiro, Ohta, Shun-ichiro, Kimoto, Yasutaka, Mitsuteru Akahoshi, Yojiro Arinobu, Hiroaki Niiro, Tada, Yoshifumi, Takahiko Horiuchi, koichi akashi

    ARTHRITIS RESEARCH & THERAPY   17   2015.2

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1186/s13075-015-0547-z

  • Human NLRP3 inflammasome senses multiple types of bacterial RNAs Reviewed International journal

    Sha, Wenwen, Hiroki Mitoma, Hanabuchi, Shino, Bao, Musheng, Weng, Leiyun, Sugimoto, Naoshi, Liu, Ying, Zhang, Zhiqiang, Zhong, Jin, Sun, Bing, Liu, Yong-Jun

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   111 ( 45 )   2014.11

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.1412487111

  • The E3 Ubiquitin Ligase Tripartite Motif 33 Is Essential for Cytosolic RNA-Induced NLRP3 Inflammasome Activation Reviewed International journal

    Weng, Leiyun, Hiroki Mitoma, Tricot, Coline, Bao, Musheng, Liu, Ying, Zhang, Zhiqiang, Liu, Yong-Jun

    JOURNAL OF IMMUNOLOGY   193 ( 7 )   2014.10

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.4049/jimmunol.1401448

  • Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system Reviewed International journal

    Sugimoto, Naoshi, Hiroki Mitoma, Kim, Taeil, Hanabuchi, Shino, Liu, Yong-Jun

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   111 ( 21 )   2014.5

    　More details

    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1073/pnas.1400139111

  • The cytotoxic effects of certolizumab pegol and golimumab mediated by transmembrane tumor necrosis factor α.

    Hiroki Mitoma, Hiroshi Tsukamoto

    Inflamm Bowel Dis   19 ( 6 )   2013.5

    　More details

    Language：English  

    DOI： 10.1097/MIB.0b013e318280b169

▼display all

Presentations

  • 難治性全身性硬化症に対する自己末梢血幹細胞移植療法の安全性と有用性の検討

    @三苫弘喜、柏戸佑介、@綾野雅宏、@森康雄、@山内拓司、塚本浩、@有信洋二郎、@堀内孝彦、@新納宏昭、@赤司浩一

    第117回日本内科学会総会・講演会  2020.8 

    　More details

    Event date： 2020.8

    Language：Japanese   Presentation type：Symposium, workshop panel (public)  

    Venue：オンライン開催   Country：Japan  

    【目的】欧米では従来治療であるシクロホスファミド間歇的静注療法との無作為化比較対照試験において，自己末梢血幹細胞療法の有用性が示されている．日本人全身性硬化症における本療法の安全性と有効性を明らかにする．
    【方法】シクロホスファミド（4g/m2）投与後の血球回復期にG-CSF製剤を投与し，アフェレーシスを行った．11例では採取した単核球から抗CD34抗体を用いて，造血幹細胞を純化した．また8例では純化を行わなかった．シクロホスファミド（200mg/kg）で前処置を行い，自己末梢血幹細胞移植を施行した．有害事象および移植後8年間のスキンスコアと肺機能の解析を行った．さらに純化群と非純化群の比較検討を行った．
    【結果】移植後8年間，スキンスコアおよび肺活量・肺拡散能の有意な改善が得られた．純化群で治療効果が高い傾向がみられた．また純化群でウイルス感染症が多い傾向にあったが，治療関連死はなく重篤な有害事象も両群で差はなかった．
    【総括】難治性全身性硬化症に対して，CD34陽性細胞純化自己末梢血幹細胞移植療法は長期間の皮膚硬化，間質性肺炎の改善が得られる可能性が示された．2017年8月より本療法を先進医療Bとして実施している．

  • 各TNF阻害剤の臨床的特徴をその多様な分子学的作用から考える Invited

    三苫 弘喜

    第５３回九州リウマチ学会  2017.3 

    　More details

    Event date： 2017.3

    Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：別府   Country：Japan  

    2003年に関節リウマチに対するTNF阻害剤が本邦で初めて承認されて以降、その高い臨床効果がリウマチ治療の変革をもたらし、現在では5剤のTNF阻害剤が保険承認されている。さらに若年性特発性関節炎、尋常性乾癬、関節症性乾癬、強直性脊椎炎などの炎症性疾患でもその有効性が示されている。一方で炎症性腸疾患、多発血管炎性肉芽腫症、サルコイドーシスなどではアダリムマブをはじめとする抗体製剤の有効性が示されているが、２型TNF受容体融合蛋白製剤では有意な臨床効果がえられていない。このことから各TNF阻害剤の分子学的作用機序や薬理学的特徴に関する研究が盛んに行われるようになり、可溶型TNFや膜型TNFの中和作用以外の知見の報告が集積されている。さらに炎症性腸疾患では腸粘膜生検によるTNF阻害剤投与前後の炎症組織の解析が可能であり、TNFおよびTNF阻害剤の生体内での作用が明らかとなってきた。
    本セッションではこれまでの報告の中から、１）膜型TNF発現細胞に対する作用（抗体依存性細胞傷害，補体依存性細胞傷害，膜型TNFのreverse signal）、 2)Fc受容体発現細胞に対する作用、 3)Neonatal Fc receptor (FcRn)を介した抗体のリサイクリングと胎盤移行、４)組織メタロプロテアーゼによる切断、5)炎症組織への分布、について各製剤の特徴を紹介したい。
    関節リウマチにおいては個々の症例において各TNF阻害剤の分子学的作用の長所を最大限に活かす薬剤選択は非常に難しいのが実情である。炎症性腸疾患を中心とするこれまでの報告を元に、今後の可能性と展望を交えながら議論したい。

  • ヒトマクロファージの細胞質における核酸の認識とインフラマゾーム活性化のメカニズム Invited

    三苫 弘喜

    日本リウマチ学会第1回アニュアルベーシックコースレクチャー  2014.10 

    　More details

    Event date： 2014.10

    Language：Japanese   Presentation type：Oral presentation (general)  

    Venue：東京   Country：Japan  

MISC

  • 【膠原病　病態治療の新たな潮流】病態と新たな治療標的　全身性強皮症

    @三苫弘喜

    アレルギーの臨床   2023.3

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 造血幹細胞移植による強皮症治療

    三苫弘喜、新納宏昭

    皮膚科　膠原病　皮疹から全身を診る   2021.5

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 全身性硬化症における造血幹細胞移植の現状と将来

    三苫弘喜、綾野雅宏

    リウマチ科   2020.5

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • Molecular mechanisms of action of anti-TNF-α agents – Comparison among therapeutic TNF-α antagonists

    Hiroki Mitoma, Takahiko Horiuchi, Hiroshi Tsukamoto, Naoyasu Ueda

    Cytokine   2018.1

    　More details

    Language：English  

    Tumor necrosis factor (TNF)-α is a potent pro-inflammatory and pathological cytokines in inflammatory diseases such as rheumatoid arthritis and inflammatory bowel diseases. Anti-TNF-α therapy has been established as an efficacious therapeutic strategy in these diseases. In clinical settings, three monoclonal anti-TNF-α full IgG1 antibodies infliximab, adalimumab, and golimumab, PEGylated Fab’ fragment of anti-TNF-α antibody certolizumab pegol, extracellular domain of TNF receptor 2/IgG1-Fc fusion protein etanercept, are almost equally effective for rheumatoid arthritis. Although monoclonal full IgG1 antibodies are able to induce clinical and endoscopic remission in inflammatory bowel diseases, certolizumab pegol without Fc portion has been shown to be less effective for inflammatory bowel diseases compared to full IgG1 antibodies. In addition, there are no evidences that etanercept leads clinical remission in inflammatory bowel diseases. Besides the common effect of anti-TNF-α agents on neutralization of soluble TNF-α, each anti-TNF-α agent has its own distinctive pharmacological properties which cause the difference in clinical efficacies. Here we focus on the distinctions of action of anti-TNF-α agents especially in following points; (1) blocking ability against ligands, transmembrane TNF-α and lymphotoxin, (2) effects toward transmembrane TNF-α-expressing cells, (3) effects toward Fcγ receptor-expressing cells, (4) degradation and distribution in inflamed tissue. Accumulating evidence will give us the idea how to modify anti-TNF-α agents to enhance the clinical efficacy in inflammatory diseases.

    DOI： 10.1016/j.cyto.2016.08.014

  • Pathogenesis of systemic sclerosis—current concept and emerging treatments

    Masutaka Furue, Chikage Mitoma, Hiroki Mitoma, Gaku Tsuji, Takahito Chiba, Takeshi Nakahara, Uchi Hiroshi, Takafumi Kadono

    Immunologic Research   2017.8

    　More details

    Language：English  

    Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activated and lead to the production of a plethora of autoantibodies, such as anti-topoisomerase I and anti-centromere antibodies. In addition to these autoantibodies, which are valuable for diagnostic criteria or biomarkers, many other autoantibodies targeting endothelial cells, including endothelin type A receptor and angiotensin II type I receptor, are known to be functional and induce activation or apoptosis of endothelial cells. The autoantibody-mediated endothelial cell perturbation facilitates inflammatory cell infiltration, cytokine production, and myofibroblastic transformation of fibroblasts and endothelial cells. Profibrotic cytokines, such as transforming growth factor β, connective tissue growth factor, interleukin 4/interleukin 13, and interleukin 6, play a pivotal role in collagen production from myofibroblasts. Specific treatments targeting these causative molecules may improve the clinical outcomes of patients with SSc. In this review, we summarize recent topics on the pathogenesis (autoantibodies, vasculopathy, and fibrosis), animal models, and emerging treatments for SSc.

    DOI： 10.1007/s12026-017-8926-y

  • 重症全身性強皮症に対する造血幹細胞移植療法

    三苫 弘喜, 塚本　浩

    リウマチ科   2017.3

    　More details

    Language：Japanese   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

▼display all

Professional Memberships

  • 九州リウマチ学会

  • 日本内科学会

  • 日本リウマチ学会

Committee Memberships

  • 日本リウマチ学会   J-STAR-BR小委員会（基礎） 委員   Domestic

    2019.9 - 2025.4   

  • 日本リウマチ学会   ワーキンググループメンバー（基礎研究推進委員会）   Domestic

    2019.4 - 2023.4   

  • 日本リウマチ学会   Councilor   Domestic

    2017.4 - 2022.3   

Academic Activities

  • International Concurrent Workshop座長

    第67回日本リウマチ学会総会・学術集会  （ Japan ） 2023.4

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    第65回九州リウマチ学会  （ Japan ） 2023.3

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    第64回九州リウマチ学会  （ Japan ） 2022.9

    　More details

    Type：Competition, symposium, etc. 

  • International Concurrent Workshop座長

    第66回日本リウマチ学会総会・学術集会  （ Japan ） 2022.4

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    第63回九州リウマチ学会  （ Japan ） 2022.3

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2022

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：4

  • 座長

    第62回九州リウマチ学会  （ Japan ） 2021.9

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    第61回九州リウマチ学会  （ Japan ） 2021.3

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    日本内科学会第332回九州地方会  （ Japan ） 2021.1

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2021

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • Screening of academic papers

    Role(s)： Peer review

    2020

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

  • Screening of academic papers

    Role(s)： Peer review

    2019

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

    Number of peer-reviewed articles in Japanese journals：1

  • 座長

    第56回九州リウマチ学会  （ Japan ） 2018.9

    　More details

    Type：Competition, symposium, etc. 

  • 座長

    日本内科学会九州地方会  （ Japan ） 2018.1

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2018

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：1

  • 座長（Chairmanship）

    日本内科学会　九州地方会  （ Japan ） 2017.1

    　More details

    Type：Competition, symposium, etc. 

  • Screening of academic papers

    Role(s)： Peer review

    2017

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：2

  • Screening of academic papers

    Role(s)： Peer review

    2016

    　More details

    Type：Peer review 

    Number of peer-reviewed articles in foreign language journals：3

▼display all

Research Projects

  • 関節リウマチにおける抑制性サイトカインの治療導入

    2024.4 - 2029.3

    　 More details

    Authorship：Coinvestigator(s) 

  • 制御性T細胞の抑制能向上による関節リウマチへの治療応用

    2024

    　 More details

    Grant type：Donation

  • 関節リウマチにおけるTph細胞に対する制御性T細胞の機能解析と治療への応用

    Grant number：22K08543  2022 - 2024

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 重症全身性硬化症に対する骨髄破壊的大量シクロホスファミド療法および純化CD34陽性自己末梢血幹細胞移植術の開発

    2019 - 2023

    国立研究開発法人日本医療研究開発機構 臨床研究・治験推進研究事業

    　 More details

    Authorship：Principal investigator  Grant type：Contract research

  • ベーチェット病におけるインフラマソーム活性化機構の解析

    Grant number：19K08911  2019 - 2021

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • 重症全身性硬化症に対する自己造血幹細胞移植の有効性に関する検討：第Ⅱ相臨床試験

    2016.4 - 2024.3

    　 More details

    Authorship：Coinvestigator(s) 

  • インフラマソームの制御機構の解明と自己免疫疾患治療への応用

    Grant number：16K09923  2016 - 2018

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

  • IL-36のヒト免疫細胞に対する作用の解明

    2015.4 - 2016.6

    九州大学病院（日本） 

    　 More details

    Authorship：Principal investigator 

  • DNase1L3の自己DNA処理機構の解明とSLEの病態形成への役割の検討

    Grant number：26893188  2014 - 2015

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Research Activity start-up

    　 More details

    Authorship：Principal investigator  Grant type：Scientific research funding

▼display all

Educational Activities

  • 免疫・膠原病疾患の診療に関するベッドサイド実習（医学部５年生）の臨床指導、クリニカルクラークシップ（医学部６年生）の臨床指導
    系統医学、臨床医学における膠原病各論の講義
    臨床医学基本実習（医学部４年生）の講義
    OSCE試験員

Class subject

  • 臨床医学基本実習

    2022.4 - 2022.9   First semester

  • 医歯薬合同講義　臨床医学

    2022.4 - 2022.9   First semester

  • アレルギー・膠原病

    2022.4 - 2022.9   First semester

  • 臨床医学基本実習

    2021.4 - 2021.9   First semester

  • 医歯薬合同講義　臨床医学

    2021.4 - 2021.9   First semester

  • アレルギー・膠原病

    2021.4 - 2021.9   First semester

  • 臨床医学基本実習

    2020.4 - 2020.9   First semester

  • 医歯薬合同講義　臨床医学

    2020.4 - 2020.9   First semester

  • アレルギー・膠原病

    2020.4 - 2020.9   First semester

  • 医歯薬合同講義　臨床医学

    2019.4 - 2019.9   First semester

  • アレルギー・膠原病

    2019.4 - 2019.9   First semester

  • 臨床医学基本実習

    2019.4 - 2019.9   First semester

  • 医歯薬合同講義　臨床医学

    2018.4 - 2018.9   First semester

  • アレルギー・膠原病

    2018.4 - 2018.9   First semester

  • 基礎医学　研究室配属

    2018.4 - 2018.9   First semester

  • 医歯薬合同講義　臨床医学

    2018.4 - 2018.9   First semester

  • アレルギー・膠原病

    2018.4 - 2018.9   First semester

  • 臨床医学基本実習

    2018.4 - 2018.9   First semester

  • 臨床医学基本実習

    2017.10 - 2018.3   Second semester

  • 臨床医学基本実習

    2017.4 - 2017.9   First semester

  • アレルギー・膠原病

    2017.4 - 2017.9   First semester

  • 臨床医学基本実習

    2016.10 - 2017.3   Second semester

  • 基礎医学　研究室配属

    2016.4 - 2016.9   First semester

  • アレルギー・膠原病

    2016.4 - 2016.9   First semester

  • 医歯薬合同講義　臨床医学

    2016.4 - 2016.9   First semester

  • 臨床医学基本実習

    2015.10 - 2016.3   Second semester

  • 基礎医学　研究室配属

    2015.4 - 2015.9   First semester

▼display all

Outline of Social Contribution and International Cooperation activities

  • 自己免疫疾患の病態メカニズムに関する講演活動
    膠原病患者さんの就労に関する講演

Social Activities

  • コンサルテーション医

    難病相談支援センター  九州大学病院  2020.4

    　More details

    Audience：General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Research consultation

  • 『全身性エリテマトーデス』について

    福岡市  福岡東保健所  2017.2

    　More details

    Audience：General,　Scientific,　Company,　Civic organization,　Governmental agency

    Type：Lecture

    全身性エリテマトーデスの症状、検査、治療、予後について、患者および家族に対して講演を行った。

Media Coverage

  • 「からだを読み解く」という別府病院の連載の中で、「関節リウマチの診断と治療」に関する最近の話題について記事を記載した。 Newspaper, magazine

    大分合同新聞社  2023.9

    　More details

    「からだを読み解く」という別府病院の連載の中で、「関節リウマチの診断と治療」に関する最近の話題について記事を記載した。

Acceptance of Foreign Researchers, etc.

  • 九州大学病院

    Acceptance period： 2020.4 - 2023.3   （Period）：1 month or more

    Nationality：China

    Business entity：Government agency

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Collagen Disease, Allergy, Infectious Disease Internal Medicine

Clinician qualification

  • Specialist

    Japan College of Rheumatology（JCR）

  • Specialist

    The Japanese Society of Internal Medicine（JSIM）

  • Preceptor

    The Japanese Society of Internal Medicine（JSIM）

  • Preceptor

    Japan College of Rheumatology（JCR）

Year of medical license acquisition

  • 1999

Notable Clinical Activities

  • 難治性全身性強化症を対象とした自己末梢血幹細胞療法を先進医療Bとして申請し、承認された。事務局を担当し、目標症例数の登録を完了した。