Updated on 2024/06/10

Information

 

写真a

 
MIMORI KOSHI
 
Organization
Beppu Hospital Department of Surgery Professor
Title
Professor
Tel
0977271645
Profile
Based on the basic concept that "the truth lies in the primitive, and various organisms have fractal relationships," we are trying to elucidate the true mechanism of the process from carcinogenesis to cancer progression and recurrence, analogous to the theory of biological evolution. In addition, we aim to solve clinical problems while improving the knowledge and techniques of basic research (dry analysis and wet analysis) with the goal of "significantly prolonging the life prognosis of cancer patients" and "solving individual patient or comprehensive disease problems in various clinical aspects". Evolution in solid tumors: In advanced colorectal cancer, many driver mutations existed clonally (Uchi R., Takahashi Y., et al. PLoS Genet 2016). On the other hand, when we analyzed the evolutionary process of early-stage colorectal cancer using a similar approach, we found that driver mutations were scattered in subclonal regions. Copy number mutations (chromosomal amplifications and deletions) were significantly more common in advanced cancers than in early-stage cancers (Saito T., Nat Commun 2018). We identified the risk alleles of ALDH2 and ADH1B polymorphisms involved in esophageal carcinogenesis (Tanaka F., GUT 2010), and for somatic mutations, we identified a comprehensive genetic mutation profile of Japanese esophageal cancer (Sawada G., 201). (Sawada G., 201), and recently, Professor Seiji Ogawa and his colleagues at Kyoto University reported a paper using the same data to clarify the evolution of esophageal cancer (Yokoyama A., Ogawa S., et al, Nature 2019). In addition, evolutionary analysis of intrahepatic cholangiocarcinoma, pancreatic cancer, and breast cancer is ongoing with the aim of searching for true therapeutic targets that are clinically useful. In addition, we are continuing our evolutionary studies of intrahepatic cholangiocarcinoma, pancreatic cancer, and breast cancer to identify clinically useful therapeutic targets. In particular, we have focused on mutated genes localized on chromosome 7 as genomic regions that undergo clonal amplification in colorectal cancer. In particular, we found a gene, 5MP1, which causes "dysregulation of protein translation start site" as a new mechanism of colorectal carcinogenesis (Sato K, EBioMed 2019). (Sato K, EBioMed 2019). We also clarified the clinical significance of the DDX56 gene, which regulates the transcription mechanism (Kouyama Y, Cancer Sci 2019). In addition, the development of SK-818 is a drug approved by Sanwa Kagaku Co., Ltd. for the treatment of chronic hepatitis B. It has been used for 20 years, and its safety has been assured to some extent. In addition, it is economically viable from the perspective of drug repositioning (expansion of indications for inexpensive drugs). The safety study was successfully completed at the end of last fiscal year. Currently, we are trying to elucidate the mechanism of action of SK818 as it shows efficacy as a single agent. We are also working hard to identify candidate drugs for various other carcinomas. Liquid Biopsy (1) Characteristics of ctDNA detected in the blood of gastrointestinal cancers: The characteristics of clones in which ctDNA mutations are detected are not clear. (1) Characteristics of ctDNA detected in blood of gastrointestinal cancers: The characteristics of clones in which ctDNA mutations are detected are not clear. We are conducting basic research to clarify the characteristics of clones in which mutations are detected in ctDNA at the time of cancer recurrence from the viewpoint of tumor immune response. (2) Chronic inflammation and gastric cancer: There is a classification method called the Kimura-Takemoto classification that classifies the extent of atrophy of the gastric mucosa based on upper gastrointestinal endoscopy. The more advanced the atrophy, the higher the risk of gastric cancer. We identified microRNAs in the serum of patients with gastric precancerous lesions. (6) Major joint research projects Representative research AMED Research Project for Creation of Next-Generation Cancer Medicine Research and Development Project: Establishment of a ctDNA detection method targeting intractable cancer-specific epigenetic mutations  Cancer genome medicine has started to recommend therapies based on mutation information for solid tumors. However, access to solid tumors is often difficult for refractory cancers such as pancreatic cancer, bile duct cancer, and recurrent colorectal cancer. Therefore, there is an urgent need to establish minimally invasive, low-cost, and highly implementable liquid biopsy (LB) with high cancer type specificity. We will focus on cancer type-specific epigenomic mutations in ctDNA for these three intractable cancers and clarify the usefulness of detection. The most important feature of LB is that it can be used to monitor tumor burden over time. In this study, we will use recurrent colorectal cancer as a model to clarify its clinical significance. Contributing research (1) PRISM Principal Investigator] Dr. Yoshihiro Yamanishi, Professor, Kyushu Institute of Technology Title of Research and Development: Search for tool substances to verify the authenticity of drug target molecules We will develop an in silico method to search for tool compounds that can be used for verification experiments of the "certainty" of drug target candidates for target diseases based on pharmaceutical big data. We will collect multi-omics data and molecular network data on various cancer types and organ fibrosis, as well as structural and experimental data of large-scale compounds including already approved drugs, discontinued development compounds, synthetic compounds, and natural compounds. We will develop statistical methods for fusion analysis of disease data and compound data, and machine learning methods that can effectively utilize diverse omics-related data to efficiently screen compounds. Finally, we will predict in silico the candidate tool compounds that regulate the candidate drug target molecules found for idiopathic pulmonary fibrosis and lung cancer. Project Title: Identification and experimental validation of molecular target drugs for gefitinib-resistant lung cancer.  Screening was completed and candidate compounds were identified. The point of action is being elucidated. (2) AMED Research Project for Practical Application of Innovative Cancer Medicine (2) AMED Innovative Cancer Medicine Research Project: [Principal Investigator] Dr. Tatsuhiro Shibata, Director, Division of Cancer Genomics, National Cancer Center Research Institute (2) AMED Innovative Cancer Medicine Project: [Principal Investigator] Dr. Tatsuhiro Shibata, Director, Division of Cancer Genomics, National Cancer Center Research Institute Title of Project: Construction and data sharing of Japanese cancer genomics database with new genome technology  In particular, we are working to elucidate the mechanisms of omics evolution in intrahepatic cholangiocarcinoma and to study tumor immune responses and metabolites as evolutionary selection pressures. (3) AMED Research Project for Practical Application of Innovative Cancer Medicine Dr. Masanobu Oshima, Professor, Institute for Cancer Research, Kanazawa University Title of Research and Development: Establishment of novel preventive treatment strategies by understanding the mechanism of colorectal cancer micrometastasis formation Elucidation of the role of fibrous niche in micrometastases 2. Elucidation of the involvement of HSCs and Kupffer cells 3. Elucidation of the interaction between cancer cells and HSCs 4. Search and validation of candidate genes 5. Validation in human colon cancer cells The above five items will be clarified by a two-person team.

Degree

  • MEDICAL DOCTOR

Research Interests・Research Keywords

  • Research theme:Identification of the novel drivers to eradicate pancreatic cancer. Particular attention is paid to the gene expression control regions in enhancer promoters.

    Keyword:Whole genome sequencing

    Research period: 2022.8

  • Research theme:liquidbiopsy

    Keyword:liquidbiopsy

    Research period: 2019.4 - 2023.3

  • Research theme:Clinical Trial for the Safety Evaluation of SK-818 for Breast Cancer Patients Conducting Curative Operations.

    Keyword:Drug repositioning

    Research period: 2018.6

  • Research theme:Evolution of Early Colorectal Cancer via Genomic Aberrations Hampering the Tumor Immune Response

    Keyword:RNAseq

    Research period: 2018.6

  • Research theme:evolutional pathway of Colorectal cancers

    Keyword:Evolution, colorectal cancer

    Research period: 2018.6

  • Research theme:Genomic analysis of hereditary GI tract tumors.

    Keyword:Lynch、〜analysis

    Research period: 2017.4 - 2019.3

Awards

  • 2021年度鶴尾隆賞

    2022.6   日本がん分子標的治療学会  

  • 日本消化器外科学会賞「JSGS Science of the Year 2017 (学術部門)」

    2017.6   日本消化器外科学会  

  • 平成26年度 大原 毅 賞受賞

    2015.6   日本消化器癌発生学会   消化器癌におけるゲノム・エピゲノムレベルにおける進化の解明と難治性を生む多様性の克服

  • 九州大学研究活動表彰受賞

    2012.11   九州大学  

  • 平成23年度「日本医師会医学研究奨励賞」

    2011.9   日本医師会  

  • 九州大学研究活動表彰受賞

    2010.11   九州大学生体防御医学研究所  

  • 公益信託 外科学研究助成基金

    2009.9   外科学会   マイクロRNAを介した癌転移機構解明に関するシンポジウムおよび技術指導

  • 第18回日本消化器癌発生学会 最優秀賞

    2007.11   日本消化器癌発生学会   【課題名】消化器癌における炎症発癌機構と癌抑制遺伝子FHITとの関係

  • かなえ研究奨励賞

    2007.9  

  • 平成19年度第1回海外派遣事業(助成)

    2007.2   がん特定領域国際交流委員会  

  • 平成18年度文部科学大臣表彰若手科学者賞

    2006.3   文部科学省   癌抑制遺伝子FHITの臨床応用に関する研究

  • 日本膵臓病学会研究奨励賞

    2005.1   日本膵臓病学会  

  • 日本癌学会研究奨励賞

    2004.10   日本癌学会  

  • 日本がん転移学会研究奨励賞

    2004.7   日本がん転移学会  

  • 国際トラベルグラント賞(助成)

    2003.10   九州大学  

  • 第12回日本がん転移学会 優秀演題賞

    2003.6   日本がん転移学会  

  • 上原記念研究助成

    2002.9   上原記念研究   研究助成

  • かなえ研究奨励賞

    2002.9  

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Papers

  • Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis

    Koshi Mimori

    Cancer Res   73 ( 7 )   2013.4

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  • MicroRNA-125a-5p is an independent prognostic factor in gastric cancer,and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Reviewed International journal

    Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.

    Clin Cancer Res.   17 ( 9 )   2011.5

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  • MicroRNA-125a-5p is an independent prognostic factor in gastric cancer,and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Reviewed International journal

    Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.

    Clin Cancer Res.   17 ( 9 )   2011.5

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  • FHIT Suppresses Inflammatory Carcinogenic Activity by Inducing Apoptosis in Esophageal Epithelial Cells. Reviewed International journal

    Mimori K, Yokobori T, Iwatsuki M, Sudo T, Tanaka F, Shibata K, Ishii H,Mori M

    J Nucleic Acid Invest   2010.5

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  • Cancer-specific chromosome alterations in the constitutive fragile region FRA3B. Reviewed International journal

    Mimori K, Druck T, Inoue H, Hansjuerg A, Berk L, Mori M, Huebner K, Croce CM.

    Proc Natl Acad Sci (USA)   96 ( 13 )   7456 - 7461   1999.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.96.13.7456

  • Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

    Mimori K, Druck T, Inoue H, Alder H, Berk L, Mori M, Huebner K and Croce CM

    Proc Natl Acad Sci (U.S.A)   96 ( 13 )   7456 - 7461   1999.6

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    DOI: 10.1073/pnas.96.13.7456

  • Case report:A rare case of triple negative breast cancer with development of acute pancreatitis due to dexamethasone during adjuvant chemotherapy. Reviewed International journal

    Ohmura H, Tobo T, Ando Y, Masuda T, Mimori K, Akashi K, Baba E.

    Front Oncol.   14   1340419 - 1340419   2024.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fonc.2024.1340419.

  • Field experiment of a telesurgery system using a surgical robot with haptic feedback. Reviewed International journal

    Ota M, Oki E, Nakanoko T, Tanaka Y, Toyota S, Hu Q, Nakaji Y, Nakanishi R, Ando K, Kimura Y, Hisamatsu Y, Mimori K, Takahashi Y, Morohashi H, Kanno T, Tadano K, Kawashima K, Takano H, Ebihara Y, Shiota M, Inokuchi J, Eto M, Yoshizumi T, Hakamada K, Hirano S, Mori M.

    Surg Today.   54 ( (4) )   375 - 381   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-023-02732-7.

  • Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis. Reviewed International journal

    Hashimoto M, Kojima Y, Sakamoto T, Ozato Y, Nakano Y, Abe T, Hosoda K, Saito H, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Hata T, Nagayama S, Kagawa K, Goto Y, Utou M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Takahashi K, Niida A, Hirose H, Hayashi S, Koseki J, Fukuchi S, Murakami K, Yoshizumi T, Kadomatsu K, Tobo T, Oda Y, Uemura M, Eguchi H, Doki Y, Mori M, Oshima M, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    105102. - 105102.   2024.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.2024.105102.

  • Implementable assay for monitoring minimum residual disease after radical treatment for colorectal cancer. Reviewed International journal

    Nakano T, Takao S, Dairaku K, Uno N, Low SA, Hashimoto M, Tsuda Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Eto K, Ikegami T, Fukunaga Y, Niida A, Nagayama S, Mimori K.

    Cancer Sci.   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.16149.

  • Liquid biopsy for breast cancer and other solid tumors: a review of recent advances. Reviewed International journal

    Ohmura H, Hanamura F, Okumura Y, Ando Y, Masuda T, Mimori K, Akashi K, Baba E.

    Breast Cancer.   2024.3

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    DOI: 10.1007/s12282-024-01556-8.

  • Tumor suppressive role of the epigenetic master regulator BRD3 in colorectal cancer. Reviewed International journal

    Hashimoto M, Masuda T, Nakano Y, Tobo T, Saito H, Koike K, Takahashi J, Abe T, Ando Y, Ozato Y, Hosoda K, Higuchi S, Hisamatsu Y, Toshima T, Yonemura Y, Hata T, Uemura M, Eguchi H, Doki Y, Mori M, Mimori K.

    Cancer Sci   2024.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.16129.

  • A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma. Reviewed International journal

    Hirose K, Toshima T, Tobo T, Kai S, Hirakawa M, Higuchi S, Ofuchi T, Hosoda K, Yonemura Y, Hisamatsu Y, Masuda T, Aishima S, Mimori K.

    Surg Case Rep.   10 ( (1) )   30 - 30   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s40792-024-01820-1.

  • What Are Risk Factors for Graft Loss in Patients Who Underwent Simultaneous Splenectomy During Living-donor Liver Transplantation? Reviewed International journal

    Toshima T, Harada N, Itoh S, Tomiyama T, Toshida K, Morita K, Nagao Y, Kurihara T, Tomino T, Kosai-Fujimoto Y, Mimori K, Yoshizumi T.

    Transplantation.   2024.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1097/TP.0000000000004952.

  • Real-time telementoring with 3D drawing annotation in robotic surgery. Reviewed International journal

    Nakanoko T, Oki E, Ota M, Ikenaga N, Hisamatsu Y, Toshima T, Kanno T, Tadano K, Kawashima K, Ohuchida K, Morohashi H, Ebihara Y, Mimori K, Nakamura M, Yoshizumi T, Hakamada K, Hirano S, Ikeda N, Mori M.

    Surg Endosc.   37 ( (12) )   9676 - 9683   2023.12

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    DOI: 10.1007/s00464-023-10521-z.

  • Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma. Reviewed International journal

    Kosai K, Masuda T, Kitagawa A, Tobo T, Ono Y, Ando Y, Takahashi J, Haratake N, Kohno M, Takenaka T, Yoshizumi T, Mimori K.

    Ann Surg Oncol.   30 ( (12) )   7538 - 7548   2023.11

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    DOI: 10.1245/s10434-023-13864-y.

  • Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers. Reviewed International journal

    Kobayashi Y, Niida A, Nagayama S, Saeki K, Haeno H, Takahashi KK, Hayashi S, Ozato Y, Saito H, Hasegawa T, Nakamura H, Tobo T, Kitagawa A, Sato K, Shimizu D, Hirata H, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Mizuno S, Kawazu M, Kohsaka S, Ueno T, Mano H, Ishihara S, Uemura M, Mori M, Doki Y, Eguchi H, Oshima M, Suzuki Y, Shibata T, Mimori K.

    Br J Cancer.   129 ( (7) )   1105 - 1118   2023.10

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    DOI: 10.1038/s41416-023-02395-8.

  • Fibrolamellar hepatocellular carcinoma: a case report and gene analysis. Reviewed International journal

    Watanabe A, Harimoto N, Saito H, Kawabata-Iwakawa R, Seki T, Muranushi R, Hoshino K, Hagiwara K, Ishii N, Tsukagoshi M, Igarashi T, Araki K, Ikota H, Ishige T, Mimori K, Shirabe K.

    Surg Case Rep.   9 ( (1) )   168. - 168.   2023.9

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    DOI: 10.1186/s40792-023-01751-3.

  • Telesurgery and telesurgical support using a double-surgeon cockpit system allowing manipulation from two locations. Reviewed International journal

    Oki E, Ota M, Nakanoko T, Tanaka Y, Toyota S, Hu Q, Nakaji Y, Nakanishi R, Ando K, Kimura Y, Hisamatsu Y, Mimori K, Takahashi Y, Morohashi H, Kanno T, Tadano K, Kawashima K, Takano H, Ebihara Y, Shiota M, Inokuchi J, Eto M, Yoshizumi T, Hakamada K, Hirano S, Mori M.

    Surg Endosc.   37 ( (8) )   6071 - 6078   2023.8

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    DOI: 10.1007/s00464-023-10061-6.

  • Hot spring bathing practices have a positive effect on mental health in Japan. Reviewed International journal

    Takeda M, Nakamura H, Otsu H, Mimori K, Maeda T, Managi S.

    Heliyon.   9 ( (9) )   2023.8

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    DOI: 10.1016/j.heliyon.2023.e19631.

  • Successful multidisciplinary treatment with complete response to atezolizumab plus bevacizumab in a 90-year-old patient with hepatocellular carcinoma recurrence. Reviewed International journal

    Hosoda K, Toshima T, Takahashi J, Yonemura Y, Hisamatsu Y, Hirose K, Masuda T, Motomura Y, Abe T, Ando Y, Dairaku K, Nakano Y, Hashimoto M, Hiraki Y, Soejima Y, Yoshizumi T, Mimori K.

    Int Cancer Conf J.   12 ( (4) )   274 - 278   2023.7

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    DOI: 10.1007/s13691-023-00618-6.

  • Trousseau's Syndrome with Advanced Neuroendocrine Carcinoma of Colon: A Case Report. Reviewed International journal

    Ohmura H, Tobo T, Mimori K, Baba E, Horiuchi T.

    Case Rep Oncol.   16 ( (1) )   484 - 490   2023.7

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    DOI: 10.1159/000530927.

  • The comprehensive review of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) from diagnosis and treatment. Reviewed International journal

    Iwatsuki M, Matsumoto C, Mimori K, Baba H.

    Ann Gastroenterol Surg.   7 ( (5) )   725 - 732   2023.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ags3.12708.

  • Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action. Reviewed International journal

    Mol Oncol.   2023.4

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    DOI: 10.1002/1878-0261.13418.

  • Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma. Invited Reviewed International journal

    Kitagawa A, Osawa T, Noda M, Kobayashi Y, Aki S, Nakano Y, Saito T, Shimizu D, Komatsu H, Sugaya M, Takahashi J, Kosai K, Takao S, Motomura Y, Sato K, Hu Q, Fujii A, Wakiyama H, Tobo T, Uchida H, Sugimachi K, Shibata K, Utsunomiya T, Kobayashi S, Ishii H, Hasegawa T, Masuda T, Matsui Y, Niida A, Soga T, Suzuki Y, Miyano S, Aburatani H, Doki Y, Eguchi H, Mori M, Nakayama KI, Shimamura T, Shibata T, Mimori K.

    British Journal of Cancer   128 ( 12 )   2206 - 2217   2023.3

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  • Dynamic Changes in Peripheral Systemic Immunity Markers During Chemotherapy in HER2-negative Advanced Breast Cancer. Reviewed International journal

    Masuda T, Ueo H, Okumura Y, Kai Y, Ando Y, Masuguchi K, Kitagawa M, Kitagawa A, Hayashi N, Tsuruda Y, Hisamatsu Y, Suehiro S, Ohmura H, Fujiyoshi K, Tanaka F, Mimori K.

    Cancer Genomics Proteomics.   20 ( 2 )   182 - 194   2023.3

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    DOI: 10.21873/cgp.20373.

  • Novel and classic approaches for managing gastrointestinal cancers. Reviewed International journal

    Mimori K.

    Ann Gastroenterol Surg.   7 ( 2 )   196 - 197   2023.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ags3.12670.

  • Rab27b, a Regulator of Exosome Secretion, Is Associated With Peritoneal Metastases in Gastric Cancer. Reviewed International journal

    Nambara S, Masuda T, Hirose K, Hu Q, Tobo T, Ozato Y, Kurashige J, Hiraki Y, Hisamatsu Y, Iguchi T, Sugimachi K, Oki E, Yoshizumi T, Mimori K.

    Cancer Genomics Proteomics.   20 ( 1 )   30 - 39   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/cgp.20362.

  • Prediction of tissue-of-origin of early stage cancers using serum miRNomes. Reviewed International journal

    6. Matsuzaki J, Kato K, Oono K, Tsuchiya N, Sudo K, Shimomura A, Tamura K, Shiino S, Kinoshita T, Daiko H, Wada T, Katai H, Ochiai H, Kanemitsu Y, Takamaru H, Abe S, Saito Y, Boku N, Kondo S, Ueno H, Okusaka T, Shimada K, Ohe Y, Asakura K, Yoshida Y, Watanabe SI, Asano N, Kawai A, Ohno M, Narita Y, Ishikawa M, Kato T, Fujimoto H, Niida S, Sakamoto H, Takizawa S, Akiba T, Okanohara D, Shiraishi K, Kohno T, Takeshita F, Nakagama H, Ota N, Ochiya T; Project Team for Development and Diagnostic Technology for Detection of miRNA in Body Fluids.

    JNCI Cancer Spectr.   7 ( 1 )   pkac080   2023.1

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    DOI: 10.1093/jncics/pkac080.

  • Mutated genes on ctDNA detecting postoperative recurrence presented reduced neoantigens in primary tumors in colorectal cancer cases. Reviewed International journal

    Nagayama S, Kobayashi Y, Fukunaga M, Sakimura S, Sugimachi K, Sasaki S, Masuda T, Mafune KI, Oshima M, Shibata T, Suzuki Y, Mimori K.

    Sci Rep   13 ( 1 )   1366   2023.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-023-28575-3.

  • Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer. Reviewed International journal

    Ozato Y, Kojima Y, Kobayashi Y, Hisamatsu Y, Toshima T, Yonemura Y, Masuda T, Kagawa K, Goto Y, Utou M, Fukunaga M, Gamachi A, Imamura K, Kuze Y, Zenkoh J, Suzuki A, Niida A, Hirose H, Hayashi S, Koseki J, Oki E, Fukuchi S, Murakami K, Tobo T, Nagayama S, Uemura M, Sakamoto T, Oshima M, Doki Y, Eguchi H, Mori M, Iwasaki T, Oda Y, Shibata T, Suzuki Y, Shimamura T, Mimori K.

    Cell Rep.   42 ( 1 )   111929   2023.1

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    DOI: 10.1016/j.celrep.2022.111929.

  • A case of malignant phyllodes tumor that responded to pazopanib and developed pneumothorax. Reviewed International journal

    Ohmura H, Masuda T, Mimori K, Baba E, Horiuchi T.

    Int Cancer Conf J.   12 ( 1 )   31 - 35   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s13691-022-00572-9.

  • Identification of serum microRNAs as potential diagnostic biomarkers for detecting precancerous lesions of gastric cancer. Reviewed International journal

    Otsu H, Nambara S, Hu Q, Hisamatsu Y, Toshima T, Takeishi K, Yonemura Y, Masuda T, Oki E, Mimori K.

    Ann Gastroenterol Surg   7 ( 1 )   63 - 70   2022.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ags3.12610.

  • The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy. Reviewed International journal

    Hirata H, Niida A, Kakiuchi N, Uchi R, Sugimachi K, Masuda T, Saito T, Kageyama SI, Motomura Y, Ito S, Yoshitake T, Tsurumaru D, Nishimuta Y, Yokoyama A, Hasegawa T, Chiba K, Shiraishi Y, Du J, Miura F, Morita M, Toh Y, Hirakawa M, Shioyama Y, Ito T, Akimoto T, Miyano S, Shibata T, Mori M, Suzuki Y, Ogawa S, Ishigami K, Mimori K.

    Cancer Res.   81 ( (19) )   4926 - 4938   2022.7

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    DOI: doi: 10.1158/0008-5472.CAN-21-0653.

  • Pan-cancer methylome analysis for cancer diagnosis and classification of cancer cell of origin. Reviewed International journal

    Shimizu D, Taniue K, Matsui Y, Haeno H, Araki H, Miura F, Fukunaga M, Shiraishi K, Miyamoto Y, Tsukamoto S, Komine A, Kobayashi Y, Kitagawa A, Yoshikawa Y, Sato K, Saito T, Ito S, Masuda T, Niida A, Suzuki M, Baba H, Ito T, Akimitsu N, Kodera Y, Mimori K.

    Cancer Gene Ther.   29 ( (5) )   428 - 436   2022.5

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    DOI: doi: 10.1038/s41417-021-00401-w.

  • Development of an intraoperative breast cancer margin assessment method using quantitative fluorescence measurements. Reviewed International journal

    Ueo H, Minoura I, Ueo H, Gamachi A, Kai Y, Kubota Y, Doi T, Yamaguchi M, Yamashita T, Tsuda H, Moriya T, Yamaguchi R, Kozuka Y, Sasaki T, Masuda T, Urano Y, Mori M, Mimori K.

    Sci Rep.   12 ( (1) )   8520 - 8520   2022.5

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    DOI: doi: 10.1038/s41598-022-12614-6.

  • Artificial intelligence-assisted drug repurposing via "chemical-induced gene expression ranking". Reviewed International journal

    Masuda T, Mimori K.

    Patterns (N Y)   3 ( (4) )   100470 - 100470   2022.4

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    DOI: doi: 10.1016/j.patter.2022.100470.

  • GET4 is a novel driver gene in colorectal cancer that regulates the localization of BAG6, a nucleocytoplasmic shuttling protein. Reviewed International journal

    Koike K, Masuda T, Sato K, Fujii A, Wakiyama H, Tobo T, Takahashi J, Motomura Y, Nakano T, Saito H, Matsumoto Y, Otsu H, Takeishi K, Yonemura Y, Mimori K, Nakagawa T.

    Cancer Sci.   113 ( (1) )   156 - 169   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/cas.15174.

  • Fanconi Anemia Complementation Group E, a DNA Repair-Related Gene, Is a Potential Marker of Poor Prognosis in Hepatocellular Carcinoma. Reviewed International journal

    Takahashi J, Masuda T, Kitagawa A, Tobo T, Nakano Y, Abe T, Ando Y, Kosai K, Kobayashi Y, Matsumoto Y, Yoshizumi T, Mori M, Mimori K.

    Oncology.   100 ( (2) )   101 - 113   2022.1

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    DOI: doi: 10.1159/000520582.

  • Nano-scale physical properties characteristic to metastatic intestinal cancer cells identified by high-speed scanning ion conductance microscope. Reviewed International journal

    Wang D, Sun L, Okuda S, Yamamoto D, Nakayama M, Oshima H, Saito H, Kouyama Y, Mimori K, Ando T, Watanabe S, Oshima M.

    Biomaterials.   Epub ( Epub )   Epub - Epub   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1016/j.biomaterials.2021.121256.

  • Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA. Reviewed International journal

    Sakano Y, Noda T, Kobayashi S, Kitagawa A, Iwagami Y, Yamada D, Tomimaru Y, Akita H, Gotoh K, Asaoka T, Tanemura M, Umeshita K, Mimori K, Doki Y, Eguchi H.

    Dig Dis Sci.   Epub ( Epub )   Epub - Epub   2021.10

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    DOI: doi: 10.1007/s10620-021-07266-x.

  • Postoperative elevation in the plasma CCL2 level is a predictive biomarker of colorectal cancer recurrence. Reviewed International journal

    Fukunaga M, Mimori K, Masuda T, Hu Q, Yamada K, Mori M.

    Surg Today.   51 ( (10) )   1671 - 1681   2021.10

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    DOI: doi: 10.1007/s00595-021-02273-x.

  • Appropriate use of cancer comprehensive genome profiling assay using circulating tumor DNA. Reviewed International journal

    Sunami K, Bando H, Yatabe Y, Naito Y, Takahashi H, Tsuchihara K, Toyooka S,Mimori K, Kohsaka S, Uetake H, Kinoshita I, Komine K, Takeda M, Hayashida T, Tamura K, Nishio K, Yamamoto N; Working Group of a Joint Task Force of Three Academic Societies for the Promotion of Cancer Genomic Medicine.

    Cancer Sci.   112 ( (9) )   3911 - 3917   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1111/cas.15022.

  • Successful Treatment with Hepatic Arterial Infusion Chemotherapy in a Breast Cancer Patient with Multiple Liver Metastases Who Declined Systemic Therapy. Reviewed International journal

    Masuda T, Niizeki O, Niizeki T, Fujiyoshi K, Ando Y, Niizeki H, Mimori K.

    Case Rep Oncol.   14 ( (3) )   1261 - 1265   2021.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: doi: 10.1159/000517854.

  • Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model. Reviewed International journal

    Ono H, Arai Y, Furukawa E, Narushima D, Matsuura T, Nakamura H, Shiokawa D, Nagai M, Imai T, Mimori K, Okamoto K, Hippo Y, Shibata T, Kato M.

    BMC Biol.   19 ( (1) )   207 - 207   2021.9

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    DOI: doi: 10.1186/s12915-021-01147-5.

  • Radiology- and gene-based risk stratification in small renal cell carcinoma: A preliminary study. Reviewed International journal

    Takao S, Ushijima Y, Motomura Y, Sakamoto K, Hirakawa M, Nishie A, Mimori K, Yamashita Y, Tsutsumi T, Ishigami K.

    PLoS One.   16 ( (9) )   e0256471 - e0256471   2021.9

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    DOI: doi: 10.1371/journal.pone.0256471.

  • Oxysterol binding protein-like 3 (OSBPL3) is a novel driver gene that promotes tumor growth in part through R-Ras/Akt signaling in gastric cancer. Reviewed International journal

    Hu Q, Masuda T, Koike K, Sato K, Tobo T, Kuramitsu S, Kitagawa A, Fujii A, Noda M, Tsuruda Y, Otsu H, Kuroda Y, Ito S, Oki E, Mimori K.

    Sci Rep.   11 ( (1) )   19178 - 19178   2021.9

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    DOI: doi: 10.1038/s41598-021-98485-9.

  • Cancer-associated Fibroblast-derived Spondin-2 Promotes Motility of Gastric Cancer Cells. Reviewed International journal

    Kuramitsu S, Masuda T, Hu Q, Tobo T, Yashiro M, Fujii A, Kitagawa A, Abe T, Otsu H, Ito S, Oki E, Mori M, Mimori K.

    Cancer Genomics Proteomics.   18 ( (4) )   521 - 529   2021.7

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    DOI: doi: 10.21873/cgp.20277.

  • Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma. Invited Reviewed International journal

    Morine Y, Utsunomiya T, Saito Y, Yamada S, Imura S, Ikemoto T, Kitagawa A, Kobayashi Y, Takao S, Kosai K, Mimori K, Tanaka Y, Shimada M.

    Oncotarget   11 ( 52 )   4803 - 4812   2021.5

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    DOI: 10.18632/oncotarget.27852.

  • Modeling colorectal cancer evolution. Reviewed International journal

    Niida A, Mimori K, Shibata T, Miyano S.

    J Hum Genet   2021.5

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    DOI: 10.1038/s10038-021-00930-0.

  • Cytolytic activity score as a biomarker for antitumor immunity and clinical outcome in patients with gastric cancer. Reviewed International journal

    Hu Q, Nonaka K, Wakiyama H, Miyashita Y, Fujimoto Y, Jogo T, Hokonohara K, Nakanishi R, Hisamatsu Y, Ando K, Kimura Y, Masuda T, Oki E, Mimori K, Oda Y, Mori M.

    Cancer Med   10 ( 9 )   3129 - 3138   2021.5

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    DOI: 10.1002/cam4.3828.

  • Mitotic checkpoint regulator RAE1 promotes tumor growth in colorectal cancer. Reviewed International journal

    Kobayashi Y, Masuda T, Fujii A, Shimizu D, Sato K, Kitagawa A, Tobo T, Ozato Y, Saito H, Kuramitsu S, Noda M, Otsu H, Mizushima T, Doki Y, Eguchi H, Mori M, Mimori K.

    Cancer Sci   2021.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14969.

  • Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT. Reviewed International journal

    Hu Q, Masuda T, Kuramitsu S, Tobo T, Sato K, Kidogami S, Nambara S, Ueda M, Tsuruda Y, Kuroda Y, Ito S, Oki E, Mori M, Mimori K.

    PLoS One   159 ( 10 )   e0241140.   2021.5

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    DOI: 10.1371/journal.pone.0241140.

  • Postoperative elevation in the plasma CCL2 level is a predictive biomarker of colorectal cancer recurrence. Reviewed International journal

    Fukunaga M, Mimori K, Masuda T, Hu Q, Yamada K, Mori M.

    Surg Today   2021.4

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    DOI: 10.1007/s00595-021-02273-x.

  • The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer. Reviewed International journal

    Fujii A, Masuda T, Iwata M, Tobo T, Wakiyama H, Koike K, Kosai K, Nakano T, Kuramitsu S, Kitagawa A, Sato K, Kouyama Y, Shimizu D, Matsumoto Y, Utsunomiya T, Ohtsuka T, Yamanishi Y, Nakamura M, Mimori K.

    Cancer Sci   112 ( 4 )   1655 - 1668   2021.4

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    DOI: 10.1111/cas.14858.

  • Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases Reviewed International journal

    Sakimura S, Nagayama S, Fukunaga M, Hu Q, Kitagawa A, Kobayashi Y, Hasegawa T, Noda M, Kouyama Y, Shimizu D, Saito T, Niida A, Tsuruda Y, Otsu H, Matsumoto Y, Uchida H, Masuda T, Sugimachi K, Sasaki S, Yamada K, Takahashi K, Innan H, Suzuki Y, Nakamura H, Totoki Y, Mizuno S, Ohshima M, Shibata T, Mimori K.

    17 ( (1) )   e1009113. - e1009113.   2021.1

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    DOI: doi: 10.1371/journal.pgen.

  • Impaired tumor immune response in metastatic tumors is a selective pressure for neutral evolution in CRC cases. Reviewed International journal

    Sakimura S, Nagayama S, Fukunaga M, Hu Q, Kitagawa A, Kobayashi Y, Hasegawa T, Noda M, Kouyama Y, Shimizu D, Saito T, Niida A, Tsuruda Y, Otsu H, Matsumoto Y, Uchida H, Masuda T, Sugimachi K, Sasaki S, Yamada K, Takahashi K, Innan H, Suzuki Y, Nakamura H, Totoki Y, Mizuno S, Ohshima M, Shibata T, Mimori K.

    PLoS Genet   17 ( 1 )   e1009113.   2021.1

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    DOI: 10.1371/journal.pgen.1009113.

  • Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer. Reviewed International journal

    Kudo SE, Kouyama Y, Ogawa Y, Ichimasa K, Hamada T, Kato K, Kudo K, Masuda T, Otsu H, Misawa M, Mori Y, Kudo T, Hayashi T, Wakamura K, Miyachi H, Sawada N, Sato T, Shibata T, Hamatani S, Nemoto T, Ishida F, Niida A, Miyano S, Oshima M, Ogino S, Mimori K.

    Clin Transl Gastroenterol.   11 ( 12 )   e00269.   2020.12

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    DOI: 10.14309/ctg.0000000000000269.

  • A case of a patient receiving combination therapy with paclitaxel plus bevacizumab and adoptive activated αβ T-cell immunotherapy in advanced breast cancer. Reviewed International journal

    26 ( 12 )   2420 - 2423   2020.12

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    DOI: 10.1111/tbj.14108

  • The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Reviewed International journal

    Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y,Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA.

    Gastroenterology   159 ( 6 )   2146 - 2162   2020.12

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    DOI: 10.1053/j.gastro.2020.08.018.

  • miR-221 Targets QKI to Enhance the Tumorigenic Capacity of Human Colorectal Cancer Stem Cells. Reviewed International journal

    Mukohyama J, Isobe T, Hu Q, Hayashi T, Watanabe T, Maeda M, Yanagi H, Qian X, Yamashita K, Minami H, Mimori K, Sahoo D, Kakeji Y, Suzuki A, Dalerba P, Shimono Y.

    Cancer Res.   79 ( 20 )   5151 - 5158   2020.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-18-3544.

  • YAP1 Activation Drives Immediate Onset of Cervical Carcinoma In Situ in Mice. Reviewed International journal

    Nishio M, To Y, Maehama T, Aono Y, Otani J, Hikasa H, Kitagawa A, Mimori K, Sasaki T, Nishina H, Toyokuni S, Lydon JP, Nakao K, Wah Mak T, Kiyono T, Katabuchi H, Tashiro H, Suzuki A.

    Cancer Sci.   Epub ( Epub )   Epub   2020.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14581.

  • The Expression Level of PD-L1 (CD274) mRNA in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. Reviewed International journal

    Masuda T, Noda M, Kitagawa A, Hu Q, Fujii A, Ito S, Kosai K, Ando Y, Matsumoto Y, Ohtsu H, Uchida H, Ohno S, Mimori K.

    Anticancer Res.   40 ( 7 )   3733 - 3742   2020.7

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    DOI: 10.21873/anticanres.14362.

  • Genetic landscape of external auditory canal squamous cell carcinoma. Reviewed International journal

    Sato K, Komune N, Hongo T, Koike K, Niida A, Uchi R, Noda T, Kogo R, Matsumoto N, Yamamoto H, Masuda M, Oda Y, Mimori K, Nakagawa T.

    Cancer Sci.   Epub ( Epub )   Epub   2020.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14515.

  • F3B4 Plays an Oncogenic Role in Esophageal Squamous Cell Carcinoma. Reviewed International journal

    Kidogami S, Iguchi T, Sato K, Yoshikawa Y, Hu Q, Nambara S, Komatsu H, Ueda M, Kuroda Y, Masuda T, Mori M, Doki Y, Mimori K.

    Anticancer Res.   40 ( 5 )   2941 - 2946   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.14272.

  • Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer. Reviewed International journal

    Ito S, Masuda T, Noda M, Hu Q, Shimizu D, Kuroda Y, Eguchi H, Tobo T, Utsunomiya T, Mimori K.

    Oncology.   98 ( 7 )   501 - 511   2020.5

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    DOI: 10.1159/000506075.

  • A unified simulation model for understanding the diversity of cancer evolution. Reviewed International journal

    Niida A, Hasegawa T, Innan H, Shibata T, Mimori K, Miyano S.

    PeerJ.   8   e8842.   2020.4

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    DOI: 10.7717/peerj.8842.

  • Drug repositioning in cancer: The current situation in Japan. Reviewed International journal

    Masuda T, Tsuruda Y, Matsumoto Y, Uchida H, Nakayama KI, Mimori K.

    Cancer Sci.   111 ( 4 )   1039 - 1046   2020.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14318.

  • Circulating PD-1 mRNA in Peripheral Blood is a Potential Biomarker for Predicting Survival of Breast Cancer Patients. Reviewed International journal

    Noda M, Masuda T, Ito S, Tobo T, Kitagawa A, Hu Q, Shimizu D, Eguchi H, Etoh T, Ohno S, Inomata M, Mimori K.

    Ann Surg Oncol.   Epub ( Epub )   Epub   2020.3

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    DOI: 10.1245/s10434-020-08375-z.

  • YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Reviewed International journal

    Omori H, Nishio M, Masuda M, Miyachi Y, Ueda F, Nakano T, Sato K, Mimori K, Taguchi K, Hikasa H, Nishina H, Tashiro H, Kiyono T, Mak TW, Nakao K, Nakagawa T, Maehama T, Suzuki A.

    Sci Adv.   6 ( 12 )   eaay3324   2020.3

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    DOI: 10.1126/sciadv.aay3324.

  • KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma. Reviewed International journal

    Kitagawa A, Masuda T, Takahashi J, Tobo T, Noda M, Kuroda Y, Hu Q, Kouyama Y, Kobayashi Y, Kuramitsu S, Sato K, Fujii A, Yoshikawa Y, Wakiyama H, Shimizu D, Tsuruda Y, Eguchi H, Doki Y, Mori M, Mimori K.

    Cancer Genomics Proteomics.   17 ( 2 )   141 - 149   2020.3

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    DOI: 10.21873/cgp.20174.

  • GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer. Reviewed International journal

    111 ( 2 )   343 - 355   2020.2

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    DOI: 10.1111/cas.14248.

  • Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer. Reviewed International journal

    Masuda T, Noda M, Kogawa T, Kitagawa D, Hayashi N, Jomori T, Nakanishi Y, Nakayama KI, Ohno S, Mimori K.

    Cancer Sci.   111 ( 3 )   924 - 931   2020.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14306.

  • N-Cadherin mRNA Levels in Peripheral Blood Could Be a Potential Indicator of New Metastases in Breast Cancer: A Pilot Study. Reviewed International journal

    Masuda T, Ueo H, Kai Y, Noda M, Hu Q, Sato K, Fujii A, Hayashi N, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Ohno S, Mimori K, Ueo H.

    Int J Mol Sci.   21 ( 2 )   511   2020.1

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    DOI: 10.3390/ijms21020511.

  • ARL4C and Peritoneal Dissemination in Gastric Cancer. Reviewed International journal

    Hu Q, Mimori K.

    Ann Surg Oncol.   26 ( Suppl 3 )   547   2019.12

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    DOI: 10.1245/s10434-018-7056-7.

  • Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer. Reviewed International journal

    Kouyama Y, Masuda T, Fujii A, Ogawa Y, Sato K, Tobo T, Wakiyama H, Yoshikawa Y, Noda M, Tsuruda Y, Kuroda Y, Eguchi H, Ishida F, Kudo SE, Mimori K.

    Cancer Sci.   110 ( 10 )   3132 - 3144   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14163.

  • Distinct methylation levels of mature microRNAs in gastrointestinal cancers. Reviewed International journal

    Konno M, Koseki J, Asai A, Yamagata A, Shimamura T, Motooka D, Okuzaki D, Kawamoto K, Mizushima T, Eguchi H, Takiguchi S, Satoh T, Mimori K, Ochiya T, Doki Y, Ofusa K, Mori M, Ishii H.

    Nat Commun.   10 ( (1) )   3888   2019.8

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    DOI: 10.1038/s41467-019-11826-1.

  • Novel oncogene 5MP1 reprograms c-Myc translation initiation to drive malignant phenotypes in colorectal cancer. Reviewed International journal

    Sato K, Masuda T, Hu Q, Tobo T, Gillaspie S, Niida A, Thornton M, Kuroda Y, Eguchi H, Nakagawa T, Asano K, Mimori K.

    EBioMedicine.   S2352-3964(19)30366-4.   2019.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.ebiom.

  • Preventive and promotive effects of habitual hot spa-bathing on the elderly in Japan. Reviewed International journal

    Maeda T, Mimori K, Suzuki S, Horiuchi T, Makino N.

    Sci Rep.   8 ( 1 )   133   2019.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-18488-3.

  • Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Reviewed International journal

    Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S,Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K,Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, NagaseT, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K,Aburatani H, Mano H.

    Cancer Sci.   110 ( 4 )   1464 - 1479   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13968.

  • Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. Reviewed International journal

    Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI.

    Cancer Sci.   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14075.

  • Potentials of C-C motif chemokine 2-C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents. Reviewed International journal

    Yumimoto K, Sugiyama S, Mimori K, Nakayama KI.

    Cancer Sci.   2019.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.14075.

  • Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Reviewed International journal

    Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.

    Cancer Sci.   110 ( 4 )   1464 - 1479   2019.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13968.

  • A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. Reviewed International journal

    Hayashi N, Kuroda Y, Saito T, Tsuruda Y, Niida A, Otsu H, Eguchi H, Masuda T, Suzuki Y, Natsugoe S, Mimori K.

    Surg Today.   2019.3

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-019-01789-7.

  • Plastin3 is associated with epithelial-mesenchymal transition and poor prognosis in gastric cancer. Reviewed International journal

    Kurashige J, Yokobori T, Mima K, Sawada G, Takahashi Y, Ueo H, Takano Y, Matsumura T, Uchi R, Eguchi H, Sudo T, Sugimachi K, Mori M, Baba H, Mimori K.

    Oncol Lett.   17 ( 2 )   2393 - 2399   2019.2

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/ol.2018.9819.

  • Age-related remodelling of oesophageal epithelia by mutated cancer drivers. Reviewed International journal

    Yokoyama A, Kakiuchi N, Yoshizato T, Nannya Y, Suzuki H, Takeuchi Y, Shiozawa Y, Sato Y, Aoki K, Kim SK, Fujii Y, Yoshida K, Kataoka K, Nakagawa MM, Inoue Y, Hirano T, Shiraishi Y, Chiba K, Tanaka H, Sanada M, Nishikawa Y, Amanuma Y, Ohashi S, Aoyama I, Horimatsu T, Miyamoto S, Tsunoda S, Sakai Y, Narahara M, Brown JB, Sato Y, Sawada G, Mimori K, Minamiguchi S, Haga H, Seno H, Miyano S, Makishima H, Muto M, Ogawa S.

    Nature.   565 ( 7739 )   312 - 317   2019.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41586-018-0811-x.

  • Multiregion Genomic Analysis of Serially Transplanted Patient-derived Xenograft Tumors. Reviewed International journal

    Sato K, Niida A, Masuda T, Shimizu D, Tobo T, Kuroda Y, Eguchi H, Nakagawa T, Suzuki Y, Mimori K.

    Cancer Genomics Proteomics.   16 ( 1 )   21 - 27   2019.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/cgp.20109.

  • CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. Reviewed International journal

    Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K.

    Anticancer Res.   39 ( 1 )   99 - 106   2019.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13084.

  • Preventive and promotive effects of habitual hot spa-bathing on the elderly in Japan Reviewed

    Toyoki Maeda, Koshi Mimori, Sadao Suzuki, Takahiko Horiuchi, Naoki Makino

    Scientific Reports   8 ( 1 )   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41598-017-18488-3

  • Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular Carcinoma (HCC). Reviewed International journal

    Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H, Mimori K.

    Anticancer Res.   38 ( 12 )   6631 - 6638   2018.12

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.13030.

  • Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients. Reviewed International journal

    Ito S, Fukagawa T, Noda M, Hu Q, Nambara S, Shimizu D, Kuroda Y, Eguchi H, Masuda T, Sato T, Katai H, Sasako M, Mimori K.

    Ann Surg Oncol.   25 ( 12 )   3755 - 3763   2018.11

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-018-6739-4.

  • Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy. Reviewed International journal

    Sugimachi K, Sakimura S, Kuramitsu S, Hirata H, Niida A, Iguchi T, Eguchi H, Masuda T, Morita M, Toh Y, Maehara Y, Suzuki Y, Mimori K.

    Br J Cancer.   119 ( 4 )   419 - 423   2018.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41416-018-0208-5.

  • Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. Reviewed International journal

    Masuda T, Shinden Y, Noda M, Ueo H, Hu Q, Yoshikawa Y, Tsuruda Y, Kuroda Y, Ito S, Eguchi H, Ohno S, Mimori K.

    Anticancer Res.   38 ( 8 )   4515 - 4523   2018.8

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.12755.

  • Cancer evolution and heterogeneity. Reviewed International journal

    Mimori K, Saito T, Niida A, Miyano S.

    Ann Gastroenterol Surg.   2 ( 5 )   332 - 338   2018.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ags3.12182.

  • Overexpression of FGFR1 Promotes Peritoneal Dissemination Via Epithelial-to-Mesenchymal Transition in Gastric Cancer. Reviewed International journal

    Shimizu D, Saito T, Ito S, Masuda T, Kurashige J, Kuroda Y, Eguchi H, Kodera Y, Mimori K.

    Cancer Genomics Proteomics.   15 ( 4 )   313 - 320   2018.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/cgp.20089.

  • A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer. Reviewed International journal

    Saito T, Niida A, Uchi R, Hirata H, Komatsu H, Sakimura S, Hayashi S, Nambara S, Kuroda Y, Ito S, Eguchi H, Masuda T, Sugimachi K, Tobo T, Nishida H, Daa T, Chiba K, Shiraishi Y, Yoshizato T, Kodama M, Okimoto T, Mizukami K, Ogawa R, Okamoto K, Shuto M, Fukuda K, Matsui Y, Shimamura T, Hasegawa T, Doki Y, Nagayama S, Yamada K, Kato M, Shibata T, Mori M, Aburatani H, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K.

    Nat Commun.   9 ( 1 )   2884   2018.7

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-018-05226-0.

  • GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. Reviewed International journal

    Tanikawa C, Kamatani Y, Takahashi A, Momozawa Y, Leveque K, Nagayama S, Mimori K, Mori M, Ishii H, Inazawa J, Yasuda J, Tsuboi A, Shimizu A, Sasaki M, Yamaji T, Sawada N, Iwasaki M, Tsugane S, Naito M, Wakai K, Koyama T, Takezaki T, Yuji K, Murakami Y, Nakamura Y, Kubo M, Matsuda K.

    Carcinogenesis.   39 ( 5 )   652 - 660   2018.5

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    DOI: 10.1093/carcin/bgy026.

  • Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling Reviewed

    Atsushi Niida, Satoshi Nagayama, Satoru Miyano, Koshi Mimori

    Cancer Science   109 ( 4 )   884 - 892   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13510

  • Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling. Reviewed International journal

    Niida A, Nagayama S, Miyano S, Mimori K.

    Cancer Sci.   109 ( 4 )   884 - 892   2018.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13510.

  • Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer Reviewed

    Eri Sakai, Mizuho Nakayama, Hiroko Oshima, Yuta Kouyama, Atsushi Niida, Satoshi Fujii, Atsushi Ochiai, Keiichi Nakayama, Koshi Mimori, Yutaka Suzuki, Chang Pyo Hong, Chan Young Ock, Seong Jin Kim, Masanobu Oshima

    Cancer Research   78 ( 5 )   1334 - 1346   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-17-3303

  • Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer Reviewed

    Qingjiang Hu, Takaaki Masuda, Kuniaki Sato, Taro Tobo, Sho Nambara, Shinya Kidogami, Naoki Hayashi, Yohsuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Hiroshi Saeki, Eiji Oki, Yoshihiko Maehara, Koshi Mimori

    Annals of Surgical Oncology   25 ( 3 )   745 - 753   2018.3

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    DOI: 10.1245/s10434-017-6292-6

  • PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer Reviewed

    Yuki Kiyozumi, Masaaki Iwatsuki, Junji Kurashige, Yoko Ogata, Kohei Yamashita, Yuki Koga, Tasuku Toihata, Yukiharu Hiyoshi, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Kazuyoshi Yanagihara, Koshi Mimori, Hideo Baba

    International Journal of Cancer   2018.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ijc.31410

  • Clinicopathological characteristics of disseminated carcinomatosis of the bone marrow in breast cancer patients. Reviewed International journal

    Shinden Y, Sugimachi K, Tanaka F, Fujiyoshi K, Kijima Y, Natsugoe S, Mimori K.

    Mol Clin Oncol.   8 ( 1 )   93 - 98   2018.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.3892/mco.2017.1502.

  • Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. Reviewed International journal

    Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.

    Oncology.   5 ( 3 )   179 - 187   2018.1

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000488860.

  • Long-term outcome of adipose-derived regenerative cell-enriched autologous fat transplantation for reconstruction after breast-conserving surgery for Japanese women with breast cancer Reviewed

    Shuhei Ito, Yuichiro Kai, Takaaki Masuda, Fumiaki Tanaka, Toshifumi Matsumoto, Yukio Kamohara, Hiroshi Hayakawa, Hiroaki Ueo, Hideki Iwaguro, Marc H. Hedrick, Koshi Mimori, Masaki Mori

    Surgery Today   47 ( 12 )   1500 - 1511   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00595-017-1544-4

  • Clinical Impact of Tumor-Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma Reviewed

    Tomoya Sudo, Ryosuke Nishida, Akihiko Kawahara, Kouhei Saisho, Koshi Mimori, Akira Yamada, Atsuhi Mizoguchi, Kazutaka Kadoya, Satoru Matono, Naoki Mori, Toshiaki Tanaka, Yoshito Akagi

    Annals of Surgical Oncology   24 ( 12 )   3763 - 3770   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-017-5796-4

  • Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14 Reviewed

    Yusuke Takahashi, Keishi Sugimachi, Ken Yamamoto, Atsushi Niida, Teppei Shimamura, Tetsuya Sato, Masahiko Watanabe, Junichi Tanaka, Shinei Kudo, Kenichi Sugihara, Kazuo Hase, Masato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Yutaka Suzuki, Satoru Miyano, Masaki Mori, Koshi Mimori

    Cancer Science   108 ( 11 )   2239 - 2247   2017.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/cas.13391

  • Diagnostic laparoscopy for pneumatosis intestinalis in a very elderly patient A case report Reviewed

    Shuhei Ito, Takaaki Masuda, Noboru Harada, Ayumi Matsuyama, Motoharu Hamatake, Takashi Maeda, Shinichi Tsutsui, Hiroyuki Matsuda, Koshi Mimori, Teruyoshi Ishida

    Annals of Medicine and Surgery   21   109 - 113   2017.9

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    DOI: 10.1016/j.amsu.2017.07.058

  • MicroRNAs as biomarkers in colorectal cancer Reviewed

    Takaaki Masuda, Naoki Hayashi, Yohsuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Koshi Mimori

    Cancers   9 ( 9 )   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/cancers9090124

  • Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma Reviewed

    Keishi Sugimachi, Miki Nishio, Shinichi Aishima, Yohsuke Kuroda, Tomohiro Iguchi, Hisateru Komatsu, Hidenari Hirata, Shotaro Sakimura, Hidetoshi Eguchi, Yuki Bekki, Kenji Takenaka, Yoshihiko Maehara, Akira Suzuki, Koshi Mimori

    Oncology   93 ( 1 )   67 - 74   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000463390

  • Overexpression of CXCR7 Is a novel prognostic indicator in gastric cancer Reviewed

    Sho Nambara, Tomohiro Iguchi, Eiji Oki, Patrick Tan, Yoshihiko Maehara, Koshi Mimori

    Digestive Surgery   34 ( 4 )   312 - 318   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000452977

  • MOB1-YAP1/TAZ-NKX2.1 axis controls bronchioalveolar cell differentiation, adhesion and tumour formation Reviewed

    Kohei Otsubo, H. Goto, M. Nishio, K. Kawamura, S. Yanagi, W. Nishie, T. Sasaki, T. Maehama, H. Nishina, Koshi Mimori, T. Nakano, H. Shimizu, T. W. Mak, K. Nakao, Yoichi Nakanishi, A. Suzuki

    Oncogene   36 ( 29 )   4201 - 4211   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/onc.2017.58

  • Extraction of cell-free DNA from urine, using polylysine-coated silica particles Reviewed

    Sho Takano, Qingjiang Hu, Takaki Amamoto, Paulo Refinetti, Koshi Mimori, Takashi Funatsu, Masaru Kato

    Fresenius Zeitschrift fur Analytische Chemie   409 ( 16 )   4021 - 4025   2017.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00216-017-0345-3

  • DDR2 expression is associated with a high frequency of peritoneal dissemination and poor prognosis in colorectal cancer Reviewed

    Shin Sasaki, Masami Ueda, Tomohiro Iguchi, Manabu Kaneko, Hiroshi Nakayama, Toshiyuki Watanabe, Atsuhiko Sakamoto, Koshi Mimori

    Anticancer Research   37 ( 5 )   2587 - 2591   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11603

  • phyC Clustering cancer evolutionary trees Reviewed

    Yusuke Matsui, Atsushi Niida, Ryutaro Uchi, Koshi Mimori, Satoru Miyano, Teppei Shimamura

    PLoS Computational Biology   13 ( 5 )   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pcbi.1005509

  • Up-regulation of SLC9A9 promotes cancer progression and is involved in poor prognosis in colorectal cancer Reviewed

    Masami Ueda, Tomohiro Iguchi, Takaaki Masuda, Hisateru Komatsu, Sho Nambara, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Hidetoshi Eguchi, Shuhei Ito, Keishi Sugimachi, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori, Koshi Mimori

    Anticancer Research   37 ( 5 )   2255 - 2263   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11562

  • Phosphoserine phosphatase is a novel prognostic biomarker on chromosome 7 in colorectal cancer Reviewed

    Kuniaki Sato, Takaaki Masuda, Qingjiang Hu, Taro Tobo, Shinya Kidogami, Yushi Ogawa, Tomoko Saito, Sho Nambara, Hisateru Komatsu, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Tomohiro Iguchi, Hidetoshi Eguchi, Shuhei Ito, Takashi Nakagawa, Koshi Mimori

    Anticancer Research   37 ( 5 )   2365 - 2371   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.21873/anticanres.11574

  • MicroRNA in various aspects of cancer development Reviewed

    Sho Nambara, Koshi Mimori

    Japanese Journal of Cancer and Chemotherapy   44 ( 5 )   362 - 366   2017.5

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  • Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma. Reviewed International journal

    Ann Surg Oncol.   24 ( 3 )   850 - 859   2017.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-016-5573-9.

  • Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma Reviewed

    Hisateru Komatsu, Tomohiro Iguchi, Takaaki Masuda, Hidenari Hirata, Masami Ueda, Shinya Kidogami, Yushi Ogawa, Kuniaki Sato, Qingjiang Hu, Sho Nambara, Tomoko Saito, Shotaro Sakimura, Ryutaro Uchi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori

    Annals of Surgical Oncology   24 ( 3 )   850 - 859   2017.3

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    DOI: 10.1245/s10434-016-5573-9

  • Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma. Reviewed International journal

    Anticancer Res.   37 ( 3 )   1083 - 1090   2017.3

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  • Overexpression of CXCR7 Is a Novel Prognostic Indicator in Gastric Cancer. Reviewed International journal

    Dig Surg   2016.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1159/000452977

  • miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. Reviewed International journal

    PLoS One   11 ( 11 )   e0165912 - e0165912   2016.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0165912

  • Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence. Reviewed International journal

    Oncotarget   7 ( 38 )   62280 - 62291   2016.9

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    DOI: 10.18632/oncotarget.11409.

  • 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis Reviewed International journal

    Ann Surg Oncol.   23 ( 4 )   546- - 551   2016.8

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-016-5374-1

  • Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma. Reviewed International journal

    Anticancer Res.   36 ( 5 )   2139 - 2144   2016.6

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  • Rapid diagnosis of lymph node metastasis in breast cancer using a new fluorescent method with γ-glutamyl hydroxymethyl rhodamine green Reviewed International journal

    9 ( 6 )   27525 - 27525   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep27525.

  • HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma. Reviewed International journal

    Anticancer Res.   36 ( 6 )   2767 - 2773   2016.6

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  • Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer. Invited Reviewed International journal

    Ann Surg Oncol   23 ( 12 )   3948 - 3955   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1245/s10434-016-5289-x

  • Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma. Reviewed International journal

    Cancer Res   76 ( 11 )   3265 - 3276   2016.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1158/0008-5472.CAN-15-2601

  • Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma. Reviewed International journal

    Hisateru Komatsu, Iguchi Tomohiro, Masami Ueda, Sho Nanbara, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Yuki Takano, Ryutaro Uchi, Shinden Yoshiaki, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Hidetoshi Eguchi, Yuichiro Doki, Masaki Mori, Koshi Mimori

    Oncol Rep   35 ( 4 )   2073 - 2080   2016.4

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    DOI: 10.3892/or.2016.4593.

  • An Integrative Analysis to Identify Driver Genes in Esophageal Squamous Cell Carcinoma. Reviewed International journal

    Genta Sawada, Atsushi Niida, HIdenari Hirata, Hisateru Komatsu, Ryutaro Uchi, Teppei Shimamura, Yusuke Takahashi, Junji Kurashige, Tae Matsumura, Hiroki Ueo, Yuki Takano, Masami Ueda, Shotaro Sakimura, Shinden Yoshiaki, Hidetoshi Eguchi, Sudo Tomoya, Keishi Sugimachi, Koshi Mimori

    PLoS One.   10 ( 10 )   e0139808   2015.10

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    DOI: 10.1371/journal.pone.0139808.

  • Identification of Recurrence-Related microRNAs from Bone Marrow in Hepatocellular Carcinoma Patients. Reviewed International journal

    Keishi Sugimachi, Shotaro Sakimura, Akira Tomokuni, Ryutaro Uchi, Hidenari Hirata, Hisateru Komatsu, Shinden Yoshiaki, Iguchi Tomohiro, Hidetoshi Eguchi, Takaaki Masuda, Kazutoyo Morita, Ken Shirabe, Hidetoshi Eguchi, Yoshihiko Maehara, Masaki Mori, Koshi Mimori

    J Clin Med.   4 ( 8 )   1600 - 1611   2015.8

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    DOI: 10.3390/jcm4081600.

  • Exosomal microRNA in serum is a novel biomarker of recurrence in human colorectal cancer. Reviewed International journal

    Tae Matsumura, Keishi Sugimachi, Hisae Iinuma, Yusuke Takahashi, Junji Kurashige, Genta Sawada, Masami Ueda, Ryutaro Uchi, Hiroki Ueda, Yuki Takano, Shinden Yoshiaki, Hidetoshi Eguchi, Hirofumi Yamamoto, Yuichiro Doki, Takahiro Ochiya, Koshi Mimori

    Br J Cancer   113 ( 2 )   275 - 281   2015.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/bjc.2015.201.

  • miR-29b is an indicator of prognosis in breast cancer patients. Reviewed International journal

    Shinden Yoshiaki, Iguchi Tomohiro, Akiyoshi Sayuri, Hiroki Ueo, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Yuki Takano, Hidetoshi Eguchi, Keishi Sugimachi, Yuko Kijima, Shoji Natsugoe, Koshi Mimori

    Mol Clin Oncol.   3 ( 4 )   919 - 923   2015.7

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    DOI: 10.3892/mco.2015.565

  • Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer. Reviewed International journal

    Masami Ueda, Iguchi Tomohiro, Sho Nanbara, Tomoko Saito, Hisateru Komatsu, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yuki Takano, Shinden Yoshiaki, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Koshi Mimori

    Ann Surg Oncol.   3   S1490. - S1498   2015.6

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    DOI: 10.1245/s10434-015-4652-7.

  • Rapid intraoperative visualization of breast lesions with γ-glutamyl hydroxymethyl rhodamine green. Invited Reviewed International journal

    13 ( 5 )   12080   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep12080.

  • A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Reviewed International journal

    Iguchi Tomohiro, Ryutaro Uchi, Sho Nanbara, Tomoko Saito, Hisateru Komatsu, Hidenatri Hitara, Masami Ueda, Shotaro Sakimura, Yuki Takano, Junji Kurashige, Shinden Yoshiaki, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori

    Anticancer Res.   35 ( 3 )   1385 - 1388   2015.5

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  • A Long Non-coding RNA Activated by Transforming Growth Factor-β is an Independent Prognostic Marker of Gastric Cancer. Reviewed International journal

    2015.5

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    BACKGROUND:

    A recent study reported that long non-coding RNA activated by TGF-β (lncRNA-ATB) induced epithelial-mesenchymal transition (EMT) through the transforming growth factor-β (TGF-β)/miR-200s/ZEB axis in hepatocellular carcinoma. Herein, we focused on the clinical significance of lncRNA-ATB in gastric cancer (GC) patients.
    MATERIALS AND METHODS:

    Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) was performed to examine expression of lncRNA-ATB, miR-200b, and miR-200c in GC tissues (n = 183). Patients were divided into high and low lncRNA-ATB expression groups using a cutoff of lncRNA-ATB/GAPDH ≥0.60 or <0.60 to determine the clinicopathological significance of lncRNA-ATB in GC. Moreover, we evaluated the expression of TGF-β, lncRNA-ATB, miR-200s, and ZEB1 in GC cell lines by qRT-PCR. GC cell lines were treated by recombinant TGF-β1 or TGF-β receptor inhibitor to examine morphologic changes and genetic alterations, such as lncRNA-ATB, miR-200s, and ZEB1 levels, with respect to the EMT phenotype.
    RESULTS:

    The high lncRNA-ATB group experienced a lower overall survival rate compared with the low lncRNA-ATB group, and multivariate analysis indicated that lncRNA-ATB was an independent prognostic factor (hazard ratio 3.50; 95 % CI 1.73-7.44; p = 0.0004). miR-200c levels were lower and ZEB1 levels were higher in the high lncRNA-ATB group than in the low lncRNA-ATB group. Treatment with TGF-β in GC cell lines resulted in morphological EMT changes, upregulation of lncRNA-ATB and ZEB1, and downregulation of miR-200c and CDH1. SB431542 reduced lncRNA-ATB expression.
    CONCLUSION:

    LncRNA-ATB plays an important role in EMT to promote invasion and metastasis through the TGF-β/miR-200s/ZEB axis, resulting in a poor prognosis in GC. LncRNA-ATB is a novel biomarker of lncRNA, indicative of a poor prognosis in GC patients.

    DOI: 10.1245/s10434-015-4554-8

  • Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer. Reviewed International journal

    Hidekazu Takahashi, Junichi Nishimura, Yoshinori Kagawa, Yoshihiro Kano, Yusuke Takahashi, Xin Wu, Masayuki Hiraki, Atsushi Hamabe, Masamitsu Konno, Naotsugu Haraguchi, Ichiro Takemasa, Tsunekazu Mizushima, Masaru Ishii, Koshi Mimori, Hideshi Ishii, Yuichiro Doki, Masaki Mori, Hirofumi Yamamoto

    Molecular Cancer Therapeutics   2015.4

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    DOI: 10.1158/1535-7163

  • F-box protein FBXW7 inhibits-cancer metastasis in a non-cell-autonomous manner Reviewed International journal

    JOURNAL OF CLINICAL INVESTIGATION   125 ( 2 )   2015.2

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    DOI: 10.1172/JCI78782

  • The miR-506-Induced Epithelial-Mesenchymal Transition is Involved in Poor Prognosis for Patients with Gastric Cancer. Reviewed International journal

    Shotaro Sakimura, Keishi Sugimachi, Junji Kurashige, Msasami Ueda, Hidenari Hirata, Sho Nanbara, Hisateru Komatsu, Tomoko Saito, Yuki Takano, Ryutaro Uchi, Etsuko Sakimura, Shinden Yoshiaki, Iguchi Tomohiro, Hidetoshi Eguchi, Yugo Oba, Sumio Hoka, Koshi Mimori

    Ann Surg Oncol.   2015.2

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    DOI: 10.1245/s10434-015-4418-2

  • Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer Reviewed International journal

    Junji Kurasige, Koshuke Mima, Genta Sawada, Yusuke Takahashi, Hidetoshi Eguchi, Keishi Sugimachi, Masaki Mori, Kazuyoshi Yanagihara, Masakazu Yashiro, Kosei Hirakawa, Hideo Baba, Koshi Mimori

    CARCINOGENESIS   36 ( 1 )   133 - 141   2015.1

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    DOI: 10.1093/carcin/bgu232

  • Overexpression of Transcription Termination Factor 1 is Associated with a Poor Prognosis in Patients with Colorectal Cancer. Reviewed International journal

    Masami Ueda, Iguchi Tomohiro, Sho Nanbara, Tomoko Saito, Hisateru Komatsu, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yuki Takano, Shinden Yoshiaki, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

    Ann Surg Oncol.   2015.1

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    DOI: 10.1245/s10434-015-4652-7

  • Diminished Expression of MiR-15a Is an Independent Prognostic Marker for Breast Cancer Cases Reviewed International journal

    Shinden Yoshiaki, Akiyoshi Sayuri, Ueo Hiroki, Sho Nanbara, Tomoko Saito, Hisateru Komatsu, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Yuki Takano, Iguchi Tomohiro, Hidetoshi Eguchi, Keishi Sugimachi, Y Kijima, Hiroaki Ueo, Shoji Natsugoe, Koshi Mimori

    ANTICANCER RESEARCH   35 ( 1 )   2015.1

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  • Epigenetic modulation and repression of miR-200b by cancer-associated fibroblasts contribute to cancer invasion and peritoneal dissemination in gastric cancer Reviewed International journal

    Junji Kurasige, Koshuke Mima, Genta Sawada, Yusuke Takahashi, Hidetoshi Eguchi, Keishi Sugimachi, Masaki Mori, Kazuyoshi Yanagihara, Masakazu Yashiro, Kosei Hirakawa, Hideo Baba, Koshi Mimori

    CARCINOGENESIS   36 ( 1 )   133 - 141   2015.1

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    DOI: 10.1093/carcin/bgu232

  • Loss of CDCP1 Expression Promotes Invasiveness and Poor Prognosis in Esophageal Squamous Cell Carcinoma Reviewed International journal

    Genta Sawada, Yusuke Takahashi, Atsushi Niida, Teppei Shimamura, Junji Kurashige, Tae Matsumura, Hiroki Ueo, Ryutaro Uchi, Yuki Takano, Masami Ueda, Hidernari Hirata, Shotaro Sakimura, Shinden Yoshiaki, Hidetoshi Eguchi, Sudo Tomoya, Keishi Sugimachi, Satoru Miyano, Yuichiro Doki, Masaki Mori, Koshi Mimori

    ANNALS OF SURGICAL ONCOLOGY   21   2014.12

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    DOI: 10.1245/s10434-014-3740-4

  • Clinical Significance of GAB2, a Scaffolding/Docking Protein Acting Downstream of EGFR in Human Colorectal Cancer Reviewed International journal

    Tae Matsumura, Keishi Sugimachi, Yusuke Takahashi, Ryutaro Uchi, Genta Sawada, Masami Ueda, Hidenari Hirata, Shotaro Sakimura, Hiroki Ueo, Yuki Takano, Junji Kurashige, Shinden Yoshiaki, Hidetoshi Eguchi, Sudo Tomoya, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

    ANNALS OF SURGICAL ONCOLOGY   21   S743 - S749   2014.12

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    DOI: 10.1245/s10434-014-3889-x

  • Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma. Reviewed International journal

    Hidenari Hirata, Keishi Sugimachi, Yusuke Takahashi, Masami Ueda, Shotaro Sakimura, Ryutaro Uchi, Junji Kurashige, Yuki Takano, Sho Nanbara, Hisateru Komatsu, Tomoko Saito, Shinden Yoshiaki, Iguchi Tomohiro, Hidetoshi Eguchi, Kazushige Atsumi, Katsumi Sakamoto, Toshio Doi, Masakazu Hirakawa, Hiroshi Honda, Koshi Mimori

    Ann Surg Oncol.   2014.11

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    DOI: 10.1245/s10434-014-4242-0

  • Prognostic Significance of High Mobility Group Box 1 (HMGB1) Expression in Patients with Colorectal Cancer Reviewed International journal

    Masami Ueda, Yusuke Takahashi, Shinden Yoshiaki, Shotaro Sakimura, Hidenari Hirata, Ryutaro Uchi, Yuki Takano, Junji Kurashige, Iguchi Tomohiro, Hidetoshi Eguchi, Keishi Sugimachi, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Koshi Mimori

    ANTICANCER RESEARCH   34 ( 10 )   5357 - 5362   2014.10

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  • Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition Reviewed International journal

    Atsushi Hamabe, Masamitsu Konno, Nobuhiro Tanuma, Hiroshi Shima, Kenta Tsunekuni, Koichi Kawamoto, Naohiro Nishida, Jun Koseki, Koshi Mimori, Noriko Gotoh, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori, Hideshi Ishii

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   111 ( 43 )   2014.10

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    DOI: 10.1073/pnas.1407717111

  • A single nucleotide polymorphism in fibronectin 1 determines tumor shape in colorectal cancer. Reviewed International journal

    Hiroyuki Kida, Yuki Takano, Ken Yamamoto, Masaki Mori, Katsuhiko Yanaga, Jun-Ichi Tanaka, Shin-Ei Kudo, Koshi Mimori

    Oncol Rep.   32 ( 2 )   548 - 552   2014.8

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    DOI: 10.3892/or.2014.3251

  • Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells.

    Koshi Mimori

    ANNALS OF SURGICAL ONCOLOGY   2014.1

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  • Up-regulation of NEK2 by MicroRNA-128 Methylation is Associated with Poor Prognosis in Colorectal Cancer

    Koshi Mimori

    ANNALS OF SURGICAL ONCOLOGY   21 ( 1 )   2014.1

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    DOI: 10.1245/s10434-013-3264-3

  • Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. International journal

    Koshi Mimori

    Br J Cancer. 2014 Jan 7;110(1):164-71. doi: 10.1038/bjc.2013.698. Epub 2013 Nov 5.   2014.1

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  • Contrasting Expression Patterns of Histone mRNA and microRNA 760 in Patients with Gastric Cancer

    Koshi Mimori

    CLINICAL CANCER RESEARCH   19 ( 23 )   2013.12

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    DOI: 10.1158/1078-0432.CCR-12-3186

  • Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo

    Koshi Mimori

    PLOS ONE   8 ( 12 )   2013.12

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    DOI: 10.1371/journal.pone.0083629

  • PICT1 regulates TP53 via RPL11 and is involved in gastric cancer progression

    Koshi Mimori

    BRITISH JOURNAL OF CANCER   109 ( 8 )   2013.10

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    DOI: 10.1038/bjc.2013.561

  • EGFR gets in the way of microRNA biogenesis

    Koshi Mimori

    CELL RESEARCH   23 ( 10 )   2013.10

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    DOI: 10.1038/cr.2013.87

  • CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer

    Koshi Mimori

    GENOME RESEARCH   23 ( 9 )   2013.9

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    DOI: 10.1101/gr.152942.112

  • Downregulation of miR-144 is associated with colorectal cancer progression via activation of mTOR signaling pathway

    Iwaya Takeshi, Yokobori Takehiko, Nishida, Naohiro, Sudo Tomoya, Fumiaki Tanaka, Shibata Kohei, Sawada, Genta, Takahashi, Yusuke, Ishibashi, Masahisa, Wakabayashi, Go, Mori, Masaki, Koshi Mimori

    CARCINOGENESIS   33 ( 12 )   2391 - 2397   2012.12

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    DOI: 10.1093/carcin/bgs288

  • MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells

    Nishida, Naohiro, Yamashita, Shinya, Koshi Mimori, Sudo Tomoya, Fumiaki Tanaka, Shibata Kohei, Yamamoto, Hirofumi, Ishii, Hideshi, Doki, Yuichiro, Mori, Masaki

    ANNALS OF SURGICAL ONCOLOGY   19 ( 9 )   3065 - 3071   2012.9

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    DOI: 10.1245/s10434-012-2246-1

  • Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24

    Ishimaru, Shinya, Koshi Mimori, Ken Yamamoto, Hiroshi Inoue, Imoto, Seiya, Shuichi; Yamaguchi, Rui; Sato, Sato Tetsuya, Toh, Hiroyuki, Iinuma, Hisae, Toyoki Maeda, Ishii, Hideshi, Suzuki, Sadao, Tokudome, Shinkan, Watanabe, Masahiko, Tanaka, Jun-ichi, Kudo, Shin-ei, Sugihara, Ken-ichi, Hase, Kazuo, Mochizuki, Hidetaka

    ANNALS OF SURGICAL ONCOLOGY   19 ( 9 )   2853 - 2858   2012.9

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    DOI: 10.1245/s10434-012-2278-6

  • Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

    Yokobori, Takehiko, Koshi Mimori, Iwatsuki, Masaaki, Ishii, Hideshi, Fumiaki Tanaka, Sato Tetsuya, Toh, Hiroyuki, Sudo Tomoya, Iwaya, Takeshi, Tanaka, Yoichi, Onoyama, Ichiro, Kuwano, Hiroyuki, Nakayama, Keiichi I., Mori, Masaki

    INTERNATIONAL JOURNAL OF ONCOLOGY   41 ( 1 )   253 - 259   2012.7

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    Language:English  

    DOI: 10.3892/ijo.2012.1436

  • Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters. Reviewed International journal

    Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Sugihara K, Doki Y, Mori M.

    Clin Cancer Res   18 ( 11 )   2012.6

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  • Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Reviewed International journal

    Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M.

    Cancer Res   71 ( 20 )   2011.8

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  • Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Reviewed International journal

    Miyoshi N, Ishii H, Nagano H, Haraguchi, Dewi DL, Kano Y Nishikawa S, Tanemura T, Mimori K, Tanaka F, Saito T, Nishimura J; Takemasa I, Mizusima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M.

    Cell Stem Cell   2011.5

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  • Clinical Significance of Circulating Tumor Cells Including Cancer Stem-like Cells in Peripheral Blood for Recurrence and Prognosis in Colorectal Cancer Patients with Dukes stage B and C. Invited Reviewed International journal

    Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Matsuda K, Fukushima R, Okinaga K, Sasako M, Mori M.

    J Clin Oncol   29   2011.5

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  • Reply to B Faltas et al. Reviewed International journal

    Iinuma H, Watanabe T, Mimori K, Adachi M, Hayashi N, Tamura J, Nozawa K, Ishihara Matsuda KN, Fukushima R, Okinaga K, Sasako M, Mori M

    J Clin Oncol   2011.5

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  • Clinical significance of miR-146a in gastric cancer cases. Reviewed International journal

    Kogo R , Mimori K, Tanaka F, Komune S, Mori M

    Clin Cancer Res   2011.5

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  • Clinical significance of miR-146a in gastric cancer cases. Reviewed International journal

    Kogo R , Mimori K, Tanaka F, Komune S, Mori M

    Clin Cancer Res   2011.5

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  • Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer. Reviewed International journal

    Mimori K*, Tahara K*, Iinuma H, Iwatsuki M, Yokobori T, Ishii H, Anai H, Kitano S,Mori M

    Ann Surg Oncol   17 ( 12 )   2011.5

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  • Regulation of the MDM2-p53 Pathway and Tumor Growth by PICT1/GLTSCR2 via Nucleolar RPL11. Reviewed International journal

    Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wangjia J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, Prives C, Nakano T, Mak TW, Sasaki T, Maehama T, Mori M, Suzuki A.

    Nat Med   2011.4

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  • Identification of Recurrence-Related microRNAs in the Bone Marrow of Breast Cancer Patients. Reviewed International journal

    Mimori K*, Ota D*, Yokobori T, Iwatsuki M, Kataoka A, Masuda N, Ishii H, Ohno S,Mori S

    Int J Oncol   2010.5

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  • Preoperative u-PAR Gene Expression in Bone Marrow Indicates the Potential Power of Recurrence in Breast Cancer Cases. International journal

    Mimori K, Kataoka A, Yamaguchi H, Masuda N, Kosaka Y, Ishii H, Ohno S, Mori M.

    Ann Surg Oncol   2009.5

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  • Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment.

    Mimori K, Ishii H, Inoue H, Barnard GF, Mori M.

    J Gastroenterol Hepatorol   2009.5

  • Important matters to identify robust markers for metastasis and recurrence in solid cancer.

    Mimori K, Iwatsuki M, Yokobori T, Mori M.

    Ann Surg Oncol   2009.5

  • Hematogenous Metastasis in Gastric Cancer Requires Isolated Tumor Cells and Expression of Vascular Endothelial Growth Factor Receptor-1

    Mimori K, Fukagawa T Kosaka Y, Kita Y, Ishikawa K, Etoh T, Iinuma H, Sasako M, Mori M

    Clin Cancer Res   2008.6

  • Loss of MAL expression in precancerous lesions of the esophagus.

    Mimori K, Nishida K Nakamura Y, Ieta K, Yoshikawa Y, Sasaki A, Ishii H, Alonso MA, Mori M

    Ann Surg Oncol   2007.1

  • Somatic mutations of epidermal growth factor receptor in colorectal carcinoma.

    Nagahara H, Mimori K, Ohta M, Utsunomiya T, Inoue H, Barnard GF, Ohira M, Hirakawa K, Mori M.

    Clin Cancer Res   11 ( 4 )   1368 - 1371   2005.1

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  • FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression.

    Mimori K, Ishii H, Nagahara H, Sudo T, Yamashita K, Inoue H, Barnard GF, MoriM

    Cancer Res   66 ( 5 )   2683 - 2690   2005.1

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  • FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression.

    Mimori K, Ishii H, Nagahara H, Sudo T, Yamashita K, Inoue H, Barnard GF, MoriM

    Cancer Res   66 ( 5 )   2683 - 2690   2005.1

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  • Coexpression of MMP-7 and EGF receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells

    Mimori K

    Clin Cancer Res   10 ( 24 )   8243 - 8249   2004.12

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    DOI: 10.1158/1078-0432.CCR-04-0849

  • MAL gene expression in esophageal cancer suppresses motility, invasion and tumorigenicity and enhances apoptosis through the Fas pathway

    Mimori K, Shiraishi T, Mashino K, Sonoda H, Yamashita K, Yoshinaga K, Masuda T, Utsunomiya T, Alonso MA, Inoue H, Mori M.

    Oncogene   22 ( 22 )   3463 - 3471   2003.1

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  • A polymorphic change at codon 299 and splicing isoforms of SMARB1 gene in human solid carcinomas.

    Mimori K, Inoue H, Ueo H, Tanaka Y, Mori M

    Genomics   2002.1

  • Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma.

    Mimori K*, Mori M*, Masuda T, Yoshinaga K, Yamashita K, Matsuyama A, Inoue H. (*equal contribution)

    Cancer Res   61 ( 20 )   7379 - 7382   2001.3

  • Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.

    Shiraishi T, Druck T, Mimori K, Flomenberg J, Berk L, Alder H, Miller W, Huebner K, Croce CM

    Proc Natl Acad Sci U S A.   2001.2

  • Effect of adenoviral trancduction of FHIT into esophageal cancer cells.

    Ishii H, Dumon K, Vacchione A, Trapasso F, Mimori K, Alder H, Mori M, Sozzi G, Baffa R, Huebner K, Croce CM.

    Cancer Res   2001.1

  • Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus.

    Mori M,Mimori K, Shiraishi T, Alder H, Inoue H, Tanaka Y, Sugimachi K, Huebner K, Croce CM.

    Cancer Res   60 ( 5 )   1177 - 1182   2000.1

  • Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas.

    Mori M, Mimori K, Ueo H, Tsuji K, Shiraishi T, Barnard GF, Sugimachi K, Akiyoshi T

    J Clin Oncol   16 ( 1 )   128 - 132   1997.1

  • p27 expression and gastric carcinoma. Reviewed

    Mori M, Mimori K, Shiraishi T, Tanaka S, Ueo H, Sugimachi K, Akiyoshi T.

    Nat Med   3 ( 6 )   593 - 593   1997.1

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  • Elongation factor 1 gamma mRNA expression in oesophageal carcinoma. International journal

    Mimori K, Mori M, Inoue H, Ueo H, Mafune K, Akiyoshi T and Sugimachi K

    Gut   38 ( 1 )   66 - 70   1996.10

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    DOI: 10.1136/gut.38.1.66

  • Elongation factor 1gamma mRNA expression in oesophageal carcinoma

    Mimori K, Mori M, Inoue H, Mafune K, Tanaka Y, Takubo T, Ueo H, Akiyoshi T, Sugimachi K.

    Gut   1996.1

  • Detection of cancer micrometastasis in lymph nodes by the reverse transcriptase-polymerase chain reaction.

    Mori M, Mimori K, Inoue H, Barnard GF, Tsuji K, Nanbara S, Ueo H, Akiyoshi T.

    Cancer Res   55 ( 15 )   3417 - 3420   1995.11

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Presentations

  • 次世代シークエンサーを用いた真の発癌・転移高リスク者を検出するnon coding RNAの同定と外科診療における意義 International conference

    三森功士、高角 康志、井上裕、飯沼 久恵、渡邊 昌彦、田中淳一、工藤 進英、望月 英隆、楠 正人、山田一隆、森 正樹、杉原 健一

    第111回日本外科学会  2011.4 

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    Event date: 2011.4 - 2012.4

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

    背景】癌診療における外科医の研究目標は、1) 発癌高リスク者を囲い込み根治術例を増やすことと、2)再発高リスク患者の早期発見による根治切除例を増やすことにあり、これを実現する真の標的分子を同定したい。他方、ごく最近全ゲノムで蛋白質翻訳領域は僅か2%で9割は転写産物(microRNAを含むnon-codingRNA)として存在することが明らかとなり、真のマーカー同定のため次世代シークエンサー(NGS)による全転写産物の解析が全世界で始まっている。【対象と方法】1)発癌因子:大腸癌1758検体と健常者2962検体を集積し、全ゲノム関連遺伝子多型解析(GWAS)。癌107例原発巣よりLMDにて癌細胞採取後RNA抽出し遺伝子アレイを実施。10例はNGSにて(全転写産物解析)を実施し、発現遺伝子とのネットワーク解析をスーパーコンピュータにて実施。2)転移因子:癌転移は癌細胞と宿主側(ニッチ)細胞群の連携で成立する。大腸癌20例の骨髄を癌細胞と宿主側3分画にFACSしmiRアレイおよびNGSにて全転写産物を解析した。【結果】1)発癌因子:大腸発癌関連多型として10p14が同定され、同多型上には既知の遺伝子は存在しないが、NGS解析により多型近傍にncRNAを同定し、多型に代わる臨床的有用性を確認した。2)転移因子:NGSにより転移陽性例特異的発現ncRNA群を同定した。ncRNAによる遺伝子制御機構は極めて複雑でありNGSでは解析情報量も多く、スーパーコンピュータによる解析技術を要した。【考察】臨床的意義を有する重要なncRNAとその経路が次々と同定されることが予想される。外科切除標本や血液・骨髄標本が解析上必須であることから、外科医は標本提供のみならず知識・技術を理解し主導的役割で臨床研究を進めていきたい。

  • Clinical Significance of microRNA in Cancer Niches. Invited International conference

    Mimori K

    MD Anderson, Research Meeting  2009.3 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:United States  

  • Comprehensive analysis of Genetic and Epidemiologic Risk Factors for Colorectal Cancer in Japan: Results of SNP, CGH and gene array analysis. Invited International conference

    Mimori K

    Department of Molecular Virology, Immunology and Medical Genetics Seminar  2009.3 

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    Event date: 2010.7

    Presentation type:Oral presentation (invited, special)  

    Country:United States  

  • Comprehensive Analysis of the Clinical Significance of Inducing Pluripotent Stemness-Related Gene Expression in Colorectal Cancer Cells International conference

    Mimori K, Saiki, Y, Mori, M.

    62th Society of Surgical Oncology (Phoenix)  2009.3 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:United States  

  • IDENTIFICATION OF THE BONA-FIDE INDICATOR OF THE RECURRENCE AND METASTASIS IN SOLID CANCERS. International conference

    Koshi Mimori and Masaki Mori

    2007.11 

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    Country:Japan  

  • Identification of Bona-fide Characteristics of Esophageal Cancer by Adenoviral-FHIT Treatment International conference

    Mimori K, Ishii H, Okamoto M, Barnard GF, Huebner K, Croce CM and Mori M

    58th Society of Surgical Oncology  2005.3 

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    INTRODUCTION The fragile histidine triad (FHIT) functions as a tumor suppressor and clinical benefits of adenoviral-FHIT (Ad-FHIT) may be expected. However, the pathways through which FHIT induces apoptosis and inhibits cancer cell growth are not known. To determine appropriate targets for Ad-FHIT mediated therapy, we performed microarray analysis between Ad-FHIT transfected cells and control cells using 3 kinds of squamous cancer cell lines. For this purpose, 1) we identified clusters of more repressed genes in Ad-FHIT cells compared to control cells, and 2) we compared clustered genes in apoptosis induced cells H1299 and TE4 by Ad-FHIT infection with genes in non apoptotic non-induced cell line, TE2.
    METHOD Three cell lines, H1299, TE4 and TE2 were transfected individually with full length FHIT and lacZ cDNA as a control. Total RNAs extracted from Ad-FHIT or AdlacZ infected samples were labeled with Cy3-dCTP or Cy5-dCTP and hybridized with a chip printed with 19,200 oligos. 1) The Ad-FHIT/Ad-control expression ratio was derived by using a random permutation test with high reproducibility from 7 repetitive
    Experiments, and 4 spots per gene on a chip. 2) The expression ratio of TE4/TE2 for eachgene was calculated to determine what genes are dominant in Ad-FHIT induced apoptotic cells.
    RESULTS 1) We identified clusters of genes reduced in Ad-FHIT, such as arachidonicacid metabolism (Table 1A) and matrix metalloprotease (MMP) related genes (Table 1B). We confirmed a reduction of PGE2 synthesis to 0.75 times control cells (range 0.35 to 0.98) by ELISA assays after exposure to LPS, IL-1 beta, or PMA stimulation in FHIT expressing cells. 2) The expression ratio of TE4 (apoptosis induced) /TE2 (non-apoptosis induced), disclosed that c-Src tyrosine kinase, tyrosine-protein kinase JAK-1 and EST (#Hs.268892) were associated with apoptosis, with ratios of 2.1, 2.4 and 6.6, respectively(Table 2).

    CONCLUSION 1) We anticipate that Ad-FHIT may be effective in certain pre-malignant cases involving inflammatory carcinogens, such as COX-2 which leads to the inhibition of apoptosis; invasion, cell proliferation, angiogenesis mediated by the PGE2 receptor Ep4; IL-1 beta which stimulates the release of prostaglandin; and ERG-1 which is a transcription factor for mPGES. Moreover, the MMP family could be a target of the Ad-FHIT gene. 2) Therefore we predict the induction of apoptosis by Ad-FHIT on far advanced esophageal cancer cases with activation of those signal pathways.

  • Loss of MAL Expression in Precancerous (Dysplastic) Lesion of the Esophagus International conference

    Mimori K, Nishida K, Ieta K, Nakamura Y, Tanaka F, Sasaki A, Inoue H, Alonso MA and Mori M.

    59th Society of Surgical Oncology  2006.3 

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    Country:United States  

    MAL expression is diminished in esophageal cancer cases and cell lines.
    MAL expression in tumor cells exerts an anti-tumorigenic effect by Fas and/or by keratins of esophageal epithelium.
    MAL expression is diminished in pre-cancerous lesions in a rat carcinogenic model, as well as in dysplastic lesions of esophageal cancer.

  • わが国における遠隔手術の将来について Invited

    三森功士

    第88回日本温泉気候物理医学会  2023.5 

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    Event date: 2023.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:別府   Country:Japan  

  • 実装化される未来のがん治療 Invited

    三森功士

    令和4年度別府市医師会学術集会  2023.3 

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    Event date: 2023.3

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:別府   Country:Japan  

  • がんの進化に関する基礎研究 Invited

    三森功士

    文科省「富岳」成果創出加速プログラム  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web   Country:Japan  

  • 進行食道がんに対する化学放射線治療後に生じた再発への進化機構の解明. Invited

    三森功士

    第35回日本バイオセラピィ学会  2022.12 

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    Event date: 2022.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福島   Country:Japan  

  • MSI-H 大腸がんにおける免疫逃避能獲得にむけたゲノム進化機構の解明. Invited

    三森功士

    第68回日本病理学会秋期特別総会  2022.11 

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    Event date: 2022.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:盛岡   Country:Japan  

  • Survivor Scientist Program Invited

    2022.10 

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    Event date: 2022.9 - 2023.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 多領域シークエンスと進化シミュレーションによるがん腫瘍内ダイバーシティの解明:大腸がんを例として Invited

    三森功士

    関東骨軟部腫瘍の基礎を語る会  2022.9 

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    Event date: 2022.9

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:web   Country:Japan  

  • 大腸がん薬物療法について Invited

    三森功士

    横浜癌診療webセミナー  2022.7 

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    Event date: 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:横浜   Country:Japan  

  • 鶴尾隆賞受賞講演 Invited

    三森功士

    第26回がん分子標的治療学会  2023.6 

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    Event date: 2022.6 - 2022.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  • Microsatellite instability-high CRC acquires frequent sub-clonal immune escape mechanisms by Darwinian evolution. Invited International conference

    2022.6 

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    Event date: 2022.6

    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • cfDNAパネルと腫瘍遺伝子パネルとの適切な役割分担とは?

    三森功士

    第19回日本臨床腫瘍学会学術集会  2022.2 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:web   Country:Japan  

  • 大腸がんゲノム進化とがん微小環境について

    三森功士

    第19回日本臨床腫瘍学会学術集会  2022.2 

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    Event date: 2022.2

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:web   Country:Japan  

  • 大腸がんの進化と選択圧となるがん微小環境について Invited

    三森 功士

    第33回早期大腸癌研究会  2021.11 

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    Event date: 2021.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:仙台   Country:Japan  

  • A Basic Traits of ctDNA To Be Applied for the Early Diagnosis of Recurrence in CRC cases Invited International conference

    Koshi Mimori

    2020.10 

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    Event date: 2020.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:China  

  • 消化器がん進化の解明〜リキッドバイオプシーの研究の最前線〜 Invited

    三森功士

    大阪大学消化器外科研究会  2020.10 

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    Event date: 2020.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:大阪   Country:Japan  

  • An overview of liquid biopsy and basic traits of ctDNA & Opinions: Liquid biopsy in the future

    2020.10 

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    Event date: 2020.10

    Language:English  

    Country:Japan  

  • 術後再発大腸がん患者においてctDNA変異検出と腫瘍免疫応答について

    三森功士、長山聡、増田隆明

    第4回Liquid Biopsy研究会  2020.1 

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    Event date: 2020.1

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 食道癌CRT耐性がんにおけるクローン進化の特徴

    三森功士、平田秀成、増田隆明

    第42回日本分子生物学会  2019.12 

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    Event date: 2019.12

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • Comprehensive analysis of the cancer evolution from primary to recurrence in sporadic CRC cases Invited International conference

    Koshi Mimori

    TEMTIA-IX(the 9th EMT International Association Meeting)  2019.11 

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    Event date: 2019.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 難治性を示す 消化器がんのクローン進化の特徴 Invited

    三森功士

    国立がん研究センター研究所セミナー  2019.5 

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    Event date: 2019.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 消化器がんにおける様々な進化機構について〜新たな大腸がん進化機構の解明〜 Invited

    三森功士

    第44回北里大学医学会総会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:神奈川   Country:Japan  

  • 食道がん放射線化学療法にみる治療ドリヴンの進化機構について

    三森功士

    第29回日本消化器癌発生学会  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:東京   Country:Japan  

  • 大腸発がんから進行がんとなり難治性を呈するまでの新たな大腸がんモデル

    三森功士

    公益財団法人高松宮妃癌研究基金 第49回国際シンポジウム  2018.11 

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    Event date: 2018.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 術後再発大腸がん患者においてctDNA変異検出ト腫瘍免疫応答について

    三森功士

    第27回日本がん転移学会学術集会・総会  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • がん進化論からみた腫瘍免疫療法の有効性についての考察 Invited

    三森功士

    第73回日本消化器外科学会総会  2018.7 

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    Event date: 2018.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:鹿児島   Country:Japan  

  • がんゲノム進化の解明と臨床応用にむけてのアプローチ Invited

    三森功士

    第117回北海道癌談話会 春期シンポジウム  2018.5 

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    Event date: 2018.5

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • Evolution of Colorectal Cancer via Genomic Alterations Hampering the Tumor Immune Respones. Invited International conference

    Koshi Mimori

    The 33rd Nagoya International Cancer Treatment Symposium  2018.2 

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    Event date: 2018.2

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 大腸がんにおける新たな進化と多様性創出機構について Invited

    三森功士

    2017.12 

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    Event date: 2017.12

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:奈良   Country:Japan  

  • 大腸の発がんと進展における「進化のシフト」について

    三森功士

    金沢大学がん進展制御研究所  共同利用・共同研究拠点シンポジウム  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  • 消化器がん転移再発診断と治療評価法に関するctDNA解析の臨床的有用性と今後の課題

    三森功士

    第55回日本癌治療学会学術集会  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:横浜   Country:Japan  

  • 食道がんゲノム情報に基づく診断と治療戦略の構築

    三森功士

    2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:福岡   Country:Japan  

  • 大腸発がんから進行がんにいたる過程のゲノムレベル進化について

    三森功士

    第3回がんゲノム・エピゲノムセミナー  2017.10 

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    Event date: 2017.10

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:札幌   Country:Japan  

  • 消化器がん症例の様々な臨床的局面における血中ctDNA突然変異検出の意義

    三森功士

    第26回日本がん転移学会  2017.7 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 消化器癌におけるctDNA検出の臨床的意義と臨床応用にむけての提言

    三森功士

    第72回日本消化器外科学会  2017.7 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  • プロパゲルマニウム(SK-818)の骨髄由来細胞制御機構による癌転移巣増殖制御について Invited

    三森 功士

    第38回日本炎症・再生医学会  2017.7 

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    Event date: 2017.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • 大腸がんの進化と転移再発を決める選択圧について Invited

    三森 功士

    昭和大学横浜北部病院 2017年消化器センター軽井沢セミナー  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:軽井沢   Country:Japan  

  • がん治療における革新的変化を踏まえた最先端技術,新たな開発戦略の現状と今後の方向性

    三森功士

    第23回抗悪性腫瘍薬開発フォーラム  2017.6 

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    Event date: 2017.6

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:東京   Country:Japan  

  • 大腸がんのゲノム解析による新たな発がん・がん進展モデルの提唱

    三森 功士

    第26回泌尿器科分子・細胞研究会  2017.3 

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    Event date: 2017.3

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大分   Country:Japan  

  • 大腸がんのゲノム・エピゲノムレベルの進化と多様性の解明 Invited

    三森 功士

    エピジェネティック療法研究会  2017.2 

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    Language:Japanese  

    Country:Japan  

  • 日本人食道癌致死率逓減のための分子遺伝学的特徴と超早期診断の実現

    三森 功士

    第35回日本口腔腫瘍学会  2017.1 

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    Event date: 2017.1

    Language:Japanese  

    Venue:福岡   Country:Japan  

  • 大腸癌のゲノム進化にみる自然選択説と中立進化説〜固形がん原発巣の一腫瘍内多様性について〜 Invited

    三森 功士

    九州胆・膵癌治療フォーラム  2017.1 

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    Event date: 2017.1

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • 大腸がんにおける多様性創出機構の解明 Invited

    三森 功士

    金沢大学がん進展制御研究所セミナー  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:金沢   Country:Japan  

  • 大腸がん原発巣の進化において多様性を生じるストレス・選択圧について Invited

    三森 功士

    第11回臨床ストレス応答学会  2016.11 

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    Event date: 2016.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:山口   Country:Japan  

  • マイクロRNAを活用した近未来がん診療

    三森 功士

    第14回日本臨床腫瘍学会  2016.7 

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    Event date: 2016.7

    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:神戸   Country:Japan  

  • がん幹細胞および幹細胞ニッチを制御する分子標的治療の確立を目指して Invited

    三森 功士

    第14回日本臨床腫瘍学会  2016.7 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:神戸   Country:Japan  

  • 乳がん根治術後の転移再発予防への挑戦〜がん転移ニッチの増殖制御をめざして〜

    三森 功士

    第25回日本がん転移学会学術集会  2016.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:米子   Country:Japan  

  • Proposal of new tactics to overcome resistance to molecular target therapy provoked heterogenetiy.

    2016.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • Proposal of new tactics to overcome resistance to molecular target therapy provoked heterogenetiy.

    2016.7 

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    Language:English   Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 大腸癌原発巣から転移巣へのゲノム・エピレベルの進化

    三森 功士, 新井田 厚司, 内 龍太郎, 高橋 佑典, 森 正樹, 宮野 悟

    第24回日本がん転移学会学術集会  2015.7 

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    Language:Japanese   Presentation type:Symposium, workshop panel (public)  

    Venue:大阪   Country:Japan  

  • PLS3 Expression in Circulating Blood Is a Good Marker for Colon Cancer Recurrence. International conference

    Ninth AACR-JCA Joint Conference  2013.2 

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    Event date: 2013.2

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 臨床応用実現にむけて『食道発癌および癌進展機構解明へのアプローチ』

    三森 功士

    第20回 日本消化器関連学会  2012.10 

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    Event date: 2012.10

    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Venue:神戸   Country:Japan  

  • Non-coding RNA, a pivotal role for carcinogenesis and cancer progression

    2012.9 

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    Event date: 2012.9

    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

  • Carcinogenesis associated SNP at 8q24 determines global CNA with poor prognosis in CRC cases International conference

    Koshi Mimori, Yasushi Takatsuno, Ken Yamamoto, Hiroshi Inoue, Masaki Mori

    2012.6 

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    Event date: 2012.6

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 遺伝学的因子および疫学環境因子から構築した大腸癌患者および食道癌患者のハイリスク者検出法の確立

    三森功士、田中文明、主藤朝也、柴田浩平

    第112回日本外科学会  2012.4 

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    Event date: 2012.4

    Venue:ホテルニューオータニ幕張   Country:Japan  

    わが国における消化器癌患者数および死亡率は増加傾向にある。癌死を改善する最善の策は早期診断・早期治療であるが、個別に発癌リスクが正確に予測できれば、リスクに応じた検査や治療を行うことが可能になる。われわれは特に罹患率が最も高い大腸癌と悪性度が最も高い食道癌を対象に、遺伝学的因子(遺伝子多型)と環境疫学因子とについて、それぞれの発癌リスクを明らかにした。

    1)大腸癌:全国9機関の研究協力体制のもと全3609例(症例群1511例、対照群2098例)を集積し、大腸発癌に関するゲノムワイド関連研究(GWAS)および144項目に及ぶアンケート解析を実施した。10p14に4つの多型を同定し危険率1.27 (1.16-1.39) (p=9.31E-08)であった。また疫学因子では高頻度肉食、20歳時BMI、糖尿病が危険因子でありツナ食、ビタミン剤内服が防御因子であった。10p14危険多型と糖尿病との有意な交互作用(2倍, p<0.01)を認めた。

    2)食道癌:全例2200例(症例群1100例、対照群1100例)を集積し食道発癌関連GWAS解析および生活習慣アンケートを実施した。多型解析の結果、アルコール代謝に重要な役割を果たすADH1B, ALDH2遺伝子多型がそれぞれオッズ比4.08 (P 値4.4E-40) 、オッズ比4.13 (P値10E-76) と食道癌患者と健常者の間に著しい差を示した。これらが飲酒と関係する遺伝子であること、また喫煙が食道癌発症に関与するために、これらの遺伝子多型と飲酒・喫煙との交互作用を検討した。その結果、これら4つの因子を全て有する場合、全く有しないヒトと比較して、食道癌発症の危険率は146倍高いことを示した。

     食道癌患者には生活習慣および遺伝子多型が危険因子は非危険因子に比べて100倍以上高いリスクを示す集団が存在し、大腸癌に関してはリスクの合計により3.6倍以上のリスクを有する集団が存在した。ハイリスク群として今後頻回の検診が必要であることを明らかにした。

  • Clinical Significance of mir-144-ZFX Axis in Isolated Tumor Cells in Bone Marrow in Gastric Cancer Cases. International conference

    65th Annual Cancer Synposium, SSO  2012.3 

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    Event date: 2012.3

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 大腸癌原発巣癌細胞における発現遺伝子プロファイルとCGH プロファイルを用いた8q24多型関連発癌および癌進展機構の解明

    三森功士、高角康志、井上 裕、田中文明、柴田浩平、杉原 健一、森 正樹

    第66回日本消化器外科学会  2011.7 

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    Event date: 2011.7 - 2012.7

    Presentation type:Symposium, workshop panel (public)  

    Venue:名古屋国際会議場   Country:Japan  

    【目的】8q24多型genotypeと実際の臨床検体におけるMYC発現との関連を明らかにした報告はない。本多型がMYCを介してDNA複製を促進して発癌に寄与するのであれば、大腸癌進展・予後にも寄与することが推察される。本研究では、8q24多型のgenotypeの臨床的意義を明らかにするとともに大腸癌ゲノムコピー数変異との関係をDukes病期別に調べ、大腸癌進展との関連を明らかにする。さらに多型と関連する機能性遺伝子群を(発現モジュール抽出)EEM解析法で明らかにする。
    【対象と方法】1)大腸癌157症例原発巣よりgenomic DNAとtotal RNAを抽出し、それそれCGHアレイと発現アレイを実施した。2)遺伝子多型情報を有する102例については最も重要な遺伝子多型locus 8q24について、その発癌機構を解明するため、そのgenotypeとCGHアレイ、あるいは発現アレイprofileとをした。また、既知のMSI,p53,K-ras,B-rafのstatusについても解析を行った。
    【結果】1)大腸癌原発巣における大腸癌細胞におけるMYC発現は8q24多型のgenotypeと有意に相関しており、Tuupananenらの報告を実際の臨床癌細胞において再現した。2)大腸癌原発巣において、rs6983267(8q24)多型はrisk alleleを有する大腸癌症例は、Dukes分類においても高度進展症例群において有意に多かった。3)上述した多型と大腸癌進展との関連が、MYCに起因する結果であることを確認するために、大腸癌ゲノムコピー数変異と多型との関係をDukes分類別に解析した。その結果、リスクアリルを有する症例群のゲノムコピー数変化(増減の絶対値)は、非リスクアリルを有する症例群にくらべて、大腸癌進展に伴い(Dukes ABからCDになるに伴い)、その変化が有意に大きいことを明らかにした。4)EEM解析の結果、細胞機能関連遺伝子群(IPAFUNCモジュール)では8q24多型とDNA複製関連遺伝子群とが相関することを明らかにし、癌関連遺伝子群(NevinsSigUDモジュール)ではMYC関連遺伝子群が極めて有意に相関していることを明らかにした。
    【結論と考察】8q24多型と相関するMYC発現がその関連分子群すべての遺伝子群の発現と相関していることをEEM解析にて明らかにした。すなわち、多型と相関するMYCを介したDNA複製が大腸癌進展に関与することをスーパーコンピュータ解析で証明された。大腸癌のゲノムのクラスター分類は、ゲノム変異の乏しいグループ1(MIN)とダイナミックな変異を示すグループ2(CIN)に分かれた。CINをきたす要因として8q24多型にともなうMYC発現増加が関連する傾向を示したが有意差はない。大腸癌は遺伝子的要因に加え環境要因も複雑に絡む多因子疾患であり、ひとつずつ丁寧に解明することにより生命予後の改善に寄与したい。

  • 大腸癌と食道癌の遺伝子多型の臨床的意義

    三森功士、田中文明、柴田浩平

    '11消化器病大会  2011.6 

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    Event date: 2011.6

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

    1)大腸癌:全国9機関の研究協力体制を確立し、アンケート、血液サンプル(全3609例:症例群1511例、対照群2098例)を集積。解析を実施した。全ゲノム相関解析による大腸癌発症関連遺伝子多型の探索を行いスクリーニング(GWAS)を実施した結果10p14に4つの多型を同定した。このうち最も有意であったgenotypeはアリル頻度差6%、オッズ比1.27(1.16-1.39)、p値は9.31E-08であった。また大腸がんの症例対照研究の結果、高頻度肉食、20歳時BMI、糖尿病が危険因子。ツナ食、ビタミン剤内服が防御因子であった。10p14危険多型と糖尿病との有意な交互作用(2倍, p<0.01)を明らかにした。一方、既知の多型8q24についても、上記邦人症例においてオッズ比1.16倍(1.06-1.27)、p値0.0015と有意な大腸発癌関連多型であることを証明し、同多型は予後因子となりうることを証明した。また8q24非危険多型集団は糖尿病により有意に発癌リスクが高まることを示した。

    2)食道癌:食道癌の生活習慣アンケートおよび多型解析用の血液を(全例2200例:症例群1100例、対照群1100例)を集積した。多型解析の結果、アルコール代謝に重要な役割を果たすADH1B, ALDH2遺伝子多型がそれぞれオッズ比4.08, P 値4.4E-40 、オッズ比4.13, P値10E-76 と食道癌患者と健常者の間に著しい差を示した。これらが飲酒と関係する遺伝子であること、また喫煙が食道癌発症に関与するために、これらの遺伝子多型と飲酒・喫煙との交互作用を検討した。その結果、これら4つの因子を全て有する場合、全く有しないヒトと比較して、食道癌発症の危険率は146倍高いことを示した。

     以上の様に食道癌では生活習慣および遺伝子多型が危険因子は非危険因子に比べて100倍以上大きな示した一方で、大腸癌は多型あるいは疫学因子における危険因子がそれぞれ2倍未満であり、大腸発癌が多因子疾患であることを改めて大規模症例研究で明らかにした。

  • EMT Induction by a gene Determines Poorer Prognosis in CRC Cases International conference

    Mimori K, Yokobori T, Ishii H, Iwatsuki M, Eguchi H, Klaus Pantel and Mori M

    7th Int'l Simposium of Minimal Residual Cancer  2010.9 

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    Event date: 2010.7

    Presentation type:Oral presentation (general)  

    Country:Greece  

  • 臨床応用にむけた消化器癌の真の転移・再発予測因子の同定について

    三森功士、深川剛生、横堀武彦、岩槻政晃、飯沼久恵、田原光一郎、笹子 三津留、森 正樹

    第64回日本消化器外科学会  2009.7 

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    Event date: 2010.7

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 大腸癌におけるEMTを制御し造腫瘍能と多分化能を有する遺伝子の臨床的意義と機能解析

    三森功士、横堀武彦、岩槻政晃、石丸神矢、秋吉清百合、永原 誠、石井秀始、森 正樹

    第18回日本がん転移学会総会  2009.7 

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    Event date: 2010.7

    Presentation type:Symposium, workshop panel (public)  

    Country:Japan  

  • 食道癌症例のエキソーム解析および発現遺伝子解析による発癌・癌進展機構の解明 Invited

    三森 功士

    日本癌学会  2013.9 

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    Language:Japanese   Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Japan  

    食道進行癌は治療抵抗性で予後不良である。治療成績向上のためには食道癌の発生、進展に関わる因子を総合的かつ俯瞰的に明らかにすることが重要である。
    1)GWASと疫学因子解析:われわれは食道癌1071名の患者と2762名の対照者について遺伝子多型および環境要因を同時に解析することにより食道発癌危険因子を明らかにした。(1)GWASの結果:ADH1B (4q23)およびALDH2 (12q24.12)というアルコール・アルデヒド代謝経路の遺伝子多型が食道癌の易罹患性に深く関わることが示された。(2)飲酒と喫煙は食道癌発症関与し、交互作用を有する;飲酒・喫煙・ADH1B・ALDH2全てにおいて危険がある場合、一つも無い場合に比べて357倍食道癌に罹患しやすいことを明らかにした。
    2)エキソーム解析: われわれは上記食道癌症例のうち代表的散発性食道癌59例の原発巣および健常組織よりLMDを用いて目的細胞のgenomic DNAおよびRNAを採取後、次世代シークエンサー NGS (Hiseq 2000 platforms)および発現アレイを用いた解析を実施した。depthの平均は94,4、10,837個のnon-synonymous変異をcodingまたはsplice siteに認めた。このうち7004個がmissense変異、226個がshort insertion/deletionであった。TP53を筆頭に、頭頸部癌で既知のNOTCH1遺伝子などに高頻度に変異を認めた。また、変異のスペクトラムを調べたところ3つのパターンにクラスタリングされ、特に遺伝子多型から推察されるアルコール代謝能のレベルと3つのクラスターとの間に関連が認められた。食道癌において飲酒とゲノム変異との関連を示す最初の解析結果となった。

  • 家族性食道癌責任領域17q25.1に注目した新規食道癌の原因遺伝子同定へのアプローチ Invited

    三森 功士

    第19回日本家族性腫瘍学会  2013.11 

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    Language:Japanese   Presentation type:Oral presentation (invited, special)  

    Country:Japan  

    掌蹠の過角化を主症状とする遺伝性掌蹠角化症の中で高率に食道扁平上皮癌を発症するTylosisという亜型が報告されている。Tylosisは常染色体優性遺伝を示すが、この家系では65歳までに罹患者の95%が食道扁平上皮癌を発症する。連鎖解析では本疾患の原因遺伝子が17q25.1上に存在することが示唆されTylosis Oesophageal Cancer (TOC) locusと命名されている。
     われわれは、散発性食道癌においてTOC領域に高頻度のLOHが認められることから、食道扁平上皮癌の原因遺伝子がこの領域に存在する可能性を報告した(Gastroenterology Iwaya et al., 1998.)。1990年代後半から近年までの間にさらに詳細な連鎖解析がなされ、TOC locusは1cM(モルガン)から50-500 kbの領域に狭められた。この領域内に存在する多くの遺伝子の解析がTylosisあるいは散発性食道癌患者を対象に行われてきた(Hum Mol Genet Kelsell DP et al.,1996, Hum Genet McRonald FE, 2006)。Tylosis家系からの解析ではCYGB遺伝子のメチル化(Hum Genet McRonald FE, 2006)やごく最近ではRHBDF2遺伝子の変異が報告されている(Am J Hum Genet, Blaydon DC et al., 2012)。散発性食道癌における解析ではEVPL遺伝子の低頻度の変異(5%)が見られたが (Oncol Rep, Iwaya et al.,2005)、他に食道扁平上皮癌に特異的な変異は同定できていなかった。現段階ではTylosis/食道扁平上皮癌の原因遺伝子その発癌メカニズムは明らかになっていない。
     上述の歴史的経緯を踏まえた上で、17q25.1上に存在することが期待される散発性食道癌あるいは家族性食道癌においても原因となる遺伝子を明らかにするために研究を行った。
     われわれは散発性食道癌60例について、原発巣および健常組織よりLMDを用いて目的細胞のみ採取した上で、次世代シークエンサーを用いた解析(RNA SeqおよびExome解析)を試み、候補遺伝子についてはin vitro, in vivoで確認した。
     RNA-seq解析では、食道癌組織で正常粘膜に比しEVPLとST6GALNAC1遺伝子の有意な発現低下が見られた。特に、ST6GALNAC1では腫瘍特異的な変異は低頻度であり、さらにメチル化による不活化の可能性が示唆された。さらに、Exome解析で17q25.1 TOC locus上の変異についてのデータを採取し、現在鋭意解析中である。
     日本では本症例の遺伝性掌蹠角化症の様な他の併存疾患なく明確に食道癌のみの家族性発症の報告はない。したがって、本発表では、併発疾患を有する食道癌症例で明らかにされている責任ゲノム領域から調べた食道癌の原因遺伝子同定への軌跡について述べる。

  • Clinical significance of u-PAR gene expression in peripheral blood and bone marrow in breast cancer cases International conference

    KoshiMimori, Akemi Kataoka, Norikazu Masuda, Takehiko Yokobori, Masaaki Iwatsuki, Shinji Ohno, Masaki Mori

    61th Society of SurgicalOncology  2008.3 

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    Country:United States  

    Introduction To predict the cancer recurrence, the evaluation of isolated tumor cells (ITC) in the peripheral blood (PB) or bone marrow (BM) by using epithelial cell markers such as CEA or cytokeratins (CK) would be useful. On the other hand, the significance of the expression of cancer related genes such as urokinase type plasminogen activator receptor (u-PAR) in PB or BM has not been clarified.
    Patients and Methods 1) We examined ITC in PB and BM from 744 cases of breast cancer (and 29 non-malignant patients as a negative control) by the quantitative real-time RT-PCR with CEA, CK-19, and CK-7. The ITC positive was determined when each one of the three genes was expressed. 2) The expressions of u-PAR in PB and BM were examined by real time RT-PCR. 3) We combined data of u-PAR and CK in comparison with each gene. 4) Serum CEA and CA15-3 levels in 298 of 744 cases were measured to compare with the u-PAR or CK status.
    Results 1) The positive result was recognized in 262 (35.4%) cases in PB, and these showed poorer disease free survival than 482 negative cases (p<0.05). 2) The 169 cases of u-PAR (+) BM showed significantly poorer disease free survival and overall survival than 575 cases of u-PAR (-) BM (p<0001 and p <0.0001, respectively). In PB, a significant difference was also observed between 309 cases of u-PAR (+) and 435 cases of u-PAR (-) (p<0.0001). 3) As for the combination of u-PAR and CK in BM, u-PAR (+)/CK(+) showed the highest recurrence rate, however, u-PAR status alone was adequate to predict recurrence in comparison with the combined data. 4) The hazard ratio for prediction of recurrence are significantly higher in u-PAR (p<0.0001; HR 0.0519) than serum CEA or CA15-3 level (not significant).
    Conclusion We found that the significance of u-PAR was much greater than the ITC alone. This means that the tumor-host reactions (one of those parameters may be the u-PAR) would be very important to predict the cancer recurrence rather than the existence of cancer cells in the circulating system, and would be much more reliable than the established serum tumor markers preoperatively.

  • A large-scale study of MT1MMP as a marker for isolated tumor cells in peripheral blood and bone marrow in gastric cancer cases International conference

    Mimori K, Fukagawa T, Kosaka Y, Ishikawa K, Etoh T, Sasako M and Mori M

    60th Society of Surgical Oncology  2007.3 

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    Country:United States  

    Introduction: This report examines the clinical outcomes of cancer patients after 12 post-operative years to determine the prognostic value of CEA mRNA in peripheral blood (PB) (Mori M., JCO 1997). In addition, a novel ITC marker, identified by microarray analysis, was validated with 959 cases of gastric cancer (GC) by Taqman RT-PCR.
    Patients and methods: 1) The clinical outcomes of 102 cases were reinvestigated and compared to evaluate CEA expression in PB. 2) Metastatic-related genes present in bone marrow (BM) were identified by cDNA microarray analysis of total RNA from the whole blood of four metastatic and four non-metastatic cases. Among the up-regulated genes in the metastatic cases, MT1MMP was chosen for further analysis. 3) MT1MMP expression was validated by Taqman RT-PCR using the PB and BM from 959 cases of GC.
    Results: 1) Among 102 cases, 12 that were CEA (-) showed novel distant metastasis; however, the incidence of CEA in PB was not associated with OS and DFS. 2) Expression levels of MT1MMP were up-regulated in metastases. MT1MMP1 localizes to the cell surface to regulate tumor invasion, and is expressed from cancer cells and/or interstitial cells via cell-cell interactions. 3) The positive rate of GC cases with MT1MMP expression in PB was larger in 13 (72%) cases with distant metastasis than in 296 (31%) cases without distant metastasis (p=0.0002). Five (27.8%) cases with distant metastasis showed a higher incidence of MT1MMP (+) in BM compared with 71 (7.3%) cases without distant metastasis. Furthermore, 3 (25%) cases with recurrence were MT1MMP (+) in BM, while 73 (7.5%) cases without recurrence were MT1MMP (-) in BM, a significant association (p=0.020).
    Conclusion: Based on the long follow-up period, we conclude that presence of the epithelial marker CEA in PB cannot be used as a prognostic or recurrent marker for GC. This large-scale study revealed that MT1MMP expression could be an effective predictor of clinical outcome in GC cases. In GC, metastasis from primary cancer tissues may require cancer cells with high metastatic potential and/or circumstances, such as MT1MMP expression in PB or BM.

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Professional Memberships

  • 日本消化器外科学会

  • 日本臨床腫瘍学会

  • 日本癌学会

  • 日本癌治療学会

  • 日本消化器癌発生学会

  • 日本がん転移学会

  • 日本外科学会

  • Society of Surgical Oncology

  • 日本がん転移学会

  • 日本大腸肛門病学会

  • 日本再生医療学会

  • 日本乳癌学会

  • 日本臨床外科学会

  • 日本がん分子標的治療学会

  • American Association for Cancer Research

  • 日本胃癌学会

  • 日本食道学会

  • 日本癌病態治療研究会

  • 日本分子生物学会

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Committee Memberships

  • 日本外科学会   遠隔手術実施推進委員   Domestic

    2024.5 - 2026.4   

  • 日本外科学会   専門医認定/予備試験委員   Domestic

    2024.5 - 2026.4   

  • 日本癌治療学会   財務委員   Domestic

    2024.2 - 2026.5   

  • 日本癌治療学会   社会連携・PAL委員   Foreign country

    2024.2 - 2026.5   

  • Executive head   Domestic

    2023.11 - 2025.10   

  • 日本消化器外科学会   学会賞選考委員、専門医制度委員、評議員選出委員、消化器外科専門医テキスト制作委員、テキスト制作実務委員   Domestic

    2023.9 - 2025.8   

  • 日本消化器外科学会   英文誌運営委員長   Domestic

    2023.9 - 2025.8   

  • Councilor   Domestic

    2023.8 - 2025.7   

  • Executive   Domestic

    2021.10 - 2023.9   

  • The European Liquid Biopsy Society   Project Partner   Foreign country

    2020.12 - 2025.12   

  • 日本外科学会   代議員   Domestic

    2018.6   

  • Executive   Domestic

    2018.6 - 2015.4   

  • 日本外科学会   専門医認定・予備試験委員   Domestic

    2018.4 - 2020.3   

  • 日本外科学会   英文誌編集委員会   Domestic

    2018.4 - 2020.3   

  • 日本消化器外科学会   教育委員会委員   Domestic

    2017.9 - 2019.8   

  • Councilor   Domestic

    2015.5 - 2020.4   

  • 日本消化器外科学会   消化器外科専門医試験作成委員会委員   Domestic

    2011.7 - 2018.6   

  • 日本癌病態治療研究会   世話人   Domestic

    2011.6 - 2018.6   

  • 日本外科学会   外科専門医試験問題検討委員会   Domestic

    2011.4 - 2018.6   

  • 日本がん転移学会   研究奨励賞選考委員会委員   Domestic

    2011.4 - 2018.6   

  • Councilor   Domestic

    2010.6 - 2018.6   

  • 日本胃癌学会   プログラム委員   Domestic

    2010.5 - 2018.6   

  • Councilor   Domestic

    2010.4 - 2018.6   

  • 日本消化器癌発生学会   会則委員会委員   Domestic

    2010.4 - 2018.6   

  • Councilor   Domestic

    2003.4 - 2018.6   

▼display all

Academic Activities

  • 司会

    第124回日本外科学会  ( 名古屋 ) 2024.4

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    Type:Competition, symposium, etc. 

  • 金沢大学がん進展制御研究所共同研究運営協議会委員

    Role(s): Review, evaluation

    金沢大学がん進展制御研究所  2024.4 - 2026.3

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    Type:Scientific advice/Review 

  • プログラムオフィサー

    Role(s): Review, evaluation

    国立研究開発法人日本医療研究開発機構  2024.4 - 2026.3

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    Type:Scientific advice/Review 

  • AMED課題評価委員

    Role(s): Review, evaluation

    国立研究開発法人日本医療研究開発機構  2024.1 - 2025.3

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    Type:Scientific advice/Review 

  • 科学技術調査員

    Role(s): Review, evaluation

    国立研究開発法人日本医療研究開発機構  2024.1 - 2024.3

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    Type:Scientific advice/Review 

  • Screening of academic papers

    Role(s): Peer review

    2024

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 司会

    第34回日本消化器癌発生学会  ( 群馬 ) 2023.11

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    Type:Competition, symposium, etc. 

  • 座長

    第21回日本消化器外科学会大会  ( 神戸 ) 2023.11

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    Type:Competition, symposium, etc. 

  • 座長

    第61回日本癌治療学会  ( 横浜 ) 2023.10

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    Type:Competition, symposium, etc. 

  • 創発的研究支援事業アドバイザー

    Role(s): Review, evaluation

    国立研究開発法人日本医療研究開発機構  2023.10 - 2024.9

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    Type:Scientific advice/Review 

  • 座長 International contribution

    第82回日本癌学会  ( 横浜 ) 2023.9

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    Type:Competition, symposium, etc. 

  • 日本消化器外科学会 英文誌運営委員会

    2023.9 - 2025.8

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    Type:Academic society, research group, etc. 

  • 座長

    慢性便秘症を考える会  ( 大分 ) 2023.7

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    Type:Competition, symposium, etc. 

  • 座長

    第32回日本がん転移学会学術集会  ( 仙台 ) 2023.7

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    Type:Competition, symposium, etc. 

  • 司会

    第78回日本消化器外科学会学術総会  ( 函館 ) 2023.7

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    Type:Competition, symposium, etc. 

  • 座長

    第27回日本がん分子標的治療学会  ( 佐賀 ) 2023.6

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    Type:Competition, symposium, etc. 

  • 司会

    第123回日本外科学会  ( 東京 ) 2023.4

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    Type:Competition, symposium, etc. 

  • 令和6年度審査・評価第二部会専門委員

    Role(s): Review, evaluation

    独立行政法人日本学術振興会  2023.4 - 2024.3

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    Type:Scientific advice/Review 

  • 座長

    第7回Liquid Biopsy研究会  ( 東京 ) 2023.1

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2023

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 座長

    第33回日本消化器癌発生学会  ( 東京 ) 2022.11

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    Type:Competition, symposium, etc. 

  • 独立行政法人日本学術振興会 科学研究費委員会専門委員

    Role(s): Review, evaluation

    独立行政法人日本学術振興会  2022.11 - 2023.10

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    Type:Scientific advice/Review 

  • 司会

    第60回日本癌治療学会  ( 神戸 ) 2022.10

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    Type:Competition, symposium, etc. 

  • 座長

    第81回日本癌学会学術総会  ( 横浜 ) 2022.9 - 2022.10

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    Type:Competition, symposium, etc. 

  • 座長

    第77回日本消化器外科学会総会  ( 横浜 ) 2022.7

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    Type:Competition, symposium, etc. 

  • 座長

    第31回日本がん転移学会  ( 京都 ) 2022.7

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    Type:Competition, symposium, etc. 

  • 群馬大学未来先端研究機関

    Role(s): Review, evaluation

    群馬大学未来先端研究機関  2022.7 - 2023.3

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    Type:Scientific advice/Review 

  • 日本癌学会喫煙対策委員会

    Role(s): Review, evaluation

    日本癌学会  2022.7

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    Type:Scientific advice/Review 

  • モデレーター

    第26回がん分子標的治療学会  ( 京都 ) 2022.6 - 2022.7

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    Type:Competition, symposium, etc. 

  • 座長

    第31回日本癌病態治療研究会  2022.6

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    Type:Competition, symposium, etc. 

  • 座長

    第43回癌免疫外科研究会  ( 京都 ) 2022.5

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    Type:Competition, symposium, etc. 

  • 司会

    第122回日本外科学会定期学術集会  ( 熊本 ) 2022.4

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    Type:Competition, symposium, etc. 

  • 熊本大学病院研究活性化プロジェクト審査員

    Role(s): Review, evaluation

    熊本大学  2022.3 - 2023.3

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    Type:Scientific advice/Review 

  • 金沢大学がん進展制御研究所共同研究運営協議会委員

    Role(s): Review, evaluation

    金沢大学  2022.3 - 2023.3

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    Type:Scientific advice/Review 

  • Screening of academic papers

    Role(s): Peer review

    2022

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 司会

    第32回日本消化器癌発生学会総会  2021.11

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    Type:Competition, symposium, etc. 

  • 座長

    第27回外科侵襲とサイトカイン研究会  2021.10

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    Type:Competition, symposium, etc. 

  • 司会

    第40回日本分子腫瘍マーカー研究会  2021.9

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    Type:Competition, symposium, etc. 

  • 消化器外科学会

    2021.9 - 2023.6

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    Type:Academic society, research group, etc. 

  • 座長

    第30回日本がん転移学会学術集会・総会  2021.7

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    Type:Competition, symposium, etc. 

  • モデレーター

    第25回日本がん分子標的治療学会  2021.5

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    Type:Competition, symposium, etc. 

  • 司会

    第121回日本外科学会定期学術集会  2021.4

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    Type:Competition, symposium, etc. 

  • 司会

    第18回日本臨床腫瘍学会  2021.2

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    Type:Competition, symposium, etc. 

  • 座長

    第5回Liquid Biopsy研究会  2021.1

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    Type:Competition, symposium, etc. 

  • 座長

    第16回TRワークショップ  2021.1

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    Type:Competition, symposium, etc. 

  • 座長

    第75回日本消化器外科学会総会  2020.12

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    Type:Competition, symposium, etc. 

  • 座長

    第31回日本消化器癌発生学会  2020.11

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    Type:Competition, symposium, etc. 

  • 座長

    第82回日本臨床外科学会  2020.10

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    Type:Competition, symposium, etc. 

  • 司会

    第58回日本癌治療学会  2020.10

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    Type:Competition, symposium, etc. 

  • 座長

    第79回日本癌学会学術集会  2020.10

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    Type:Competition, symposium, etc. 

  • 座長

    第40回 日本分子腫瘍マーカー研究会  2020.9

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    Type:Competition, symposium, etc. 

  • 司会

    第120回日本外科学会定期学術集会  2020.8

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    Type:Competition, symposium, etc. 

  • 司会

    第41回癌免疫外科研究会  ( 大阪 ) 2020.7

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    Type:Competition, symposium, etc. 

  • 卓越研究員候補者選考委員会書面審査員及び国際事業委員会書面審査員・書面評価員

    Role(s): Review, evaluation

    日本学術振興会  2020.7 - 2021.6

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    Type:Scientific advice/Review 

  • 特別研究員等審査会専門委員

    Role(s): Review, evaluation

    日本学術振興会  2020.7 - 2021.6

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    Type:Scientific advice/Review 

  • Screening of academic papers

    Role(s): Peer review

    2020

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • オーガナイザー

    第42回日本分子生物学会  ( 福岡 ) 2019.12

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    Type:Competition, symposium, etc. 

  • 司会

    第30回日本消化器癌発生学会  ( 横浜 ) 2019.11

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    Type:Competition, symposium, etc. 

  • English Session 座長

    第78回日本癌学会  ( 京都 ) 2019.9

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    Type:Competition, symposium, etc. 

  • 座長

    第78回日本癌学会  ( 京都 ) 2019.9

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    Type:Competition, symposium, etc. 

  • 司会

    第74回日本消化器外科学会総会  ( 東京 ) 2019.7

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    Type:Competition, symposium, etc. 

  • 司会

    第28回日本癌病態治療研究会  ( 川越 ) 2019.6

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    Type:Competition, symposium, etc. 

  • 司会

    第73回日本食道学会  ( 福岡 ) 2019.6

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    Type:Competition, symposium, etc. 

  • 司会

    第40回癌免疫外科研究会  ( 金沢 ) 2019.5

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    Type:Competition, symposium, etc. 

  • 司会

    第119回日本外科学会定期学術集会  ( 大阪 ) 2019.4

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    Type:Competition, symposium, etc. 

  • 座長

    第29回日本消化器癌発生学会  ( 東京 ) 2018.11

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    Type:Competition, symposium, etc. 

  • 座長 International contribution

    第77回日本癌学会学術総会  ( 大阪 ) 2018.9

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    Type:Competition, symposium, etc. 

  • 司会

    第73回日本消化器外科学会総会  ( 鹿児島 ) 2018.7

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    Type:Competition, symposium, etc. 

  • 司会

    第27回日本病態治療研究会  ( 千葉 ) 2018.5 - 2018.6

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    Type:Competition, symposium, etc. 

  • 司会

    第118回日本外科学会定期学術集会  ( 東京 ) 2018.4

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    Type:Competition, symposium, etc. 

  • 日本外科学会英文誌編集委員会

    2018.4 - 2020.3

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    Type:Academic society, research group, etc. 

  • 座長

    第1回「別府がん若手研究者の勉強会」  ( 別府市 ) 2017.10

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    Type:Competition, symposium, etc. 

    Number of participants:60

  • 座長

    JDDW2017  ( 福岡 ) 2017.10

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    Type:Competition, symposium, etc. 

  • 座長

    第76回日本癌学会学術総会  ( 横浜 ) 2017.9

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    Type:Competition, symposium, etc. 

  • 座長

    第26回日本がん転移学会  ( 大阪 ) 2017.7

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    Type:Competition, symposium, etc. 

  • 座長

    第72回日本消化器外科学会  ( 金沢 ) 2017.7

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    Type:Competition, symposium, etc. 

  • 司会

    第87回大腸癌研究会  ( 四日市 ) 2017.7

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    Type:Competition, symposium, etc. 

  • 座長

    第21回日本がん分子標的治療学会  ( 福岡 ) 2017.6

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    Type:Competition, symposium, etc. 

  • 座長

    第27回日本サイトメトリー学会  ( 神戸 ) 2017.6 - 2018.6

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    Type:Competition, symposium, etc. 

  • 司会

    第26回日本癌病態治療研究会  ( 横浜 ) 2017.6

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    Type:Competition, symposium, etc. 

  • 司会

    第38回癌免疫外科研究会  ( 倉敷 ) 2017.5

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    Type:Competition, symposium, etc. 

  • 司会

    第117回日本外科学会  ( 横浜 ) 2017.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第89回日本胃癌学会  ( 広島 ) 2017.3

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    Type:Competition, symposium, etc. 

  • Screening of academic papers

    Role(s): Peer review

    2017

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    Type:Peer review 

    Number of peer-reviewed articles in foreign language journals:20

  • 司会(Moderator)

    第7回癌・炎症と抗酸化研究会(CIA研究会)  ( 大分 ) 2016.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第78回日本臨床外科学会  ( 東京 ) 2016.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 神戸 ) 2016.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 京都 ) 2016.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第75回日本癌学会学術集会  ( 横浜 ) 2016.10

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    Type:Competition, symposium, etc. 

  • 司会(Moderator)

    第27回日本消化器癌発生学会  ( 鹿児島 ) 2016.9

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    Type:Competition, symposium, etc. 

  • 次世代がん研究シーズ戦略的育成プログラム 事後評価委員会委員

    Role(s): Review, evaluation

    国立研究開発法人 日本医療研究開発機構  2016.9 - 2017.3

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第20回日本がん免疫学会  ( 大阪 ) 2016.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第26回日本サイトメトリー学会学術集会  ( 福岡 ) 2016.7

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    Type:Competition, symposium, etc. 

  • 司会(Moderator)

    第25回日本癌病態治療研究会  ( 千葉 ) 2016.6

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    Type:Competition, symposium, etc. 

  • 司会(Moderator)

    第116回日本外科学会  ( 大阪 ) 2016.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第26回日本消化器癌発生学会総会  ( 米子 ) 2015.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    JDDW2015  ( 東京 ) 2015.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第74回日本癌学会学術総会  ( 名古屋 ) 2015.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第35回日本分子腫瘍マーカー研究会  2015.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第24回日本がん転移学会学術集会  ( 大阪 ) 2015.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第70回日本消化器外科学会  ( 浜松 ) 2015.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第36回癌免疫外科研究回  ( 奄美大島 ) 2015.5

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    Type:Competition, symposium, etc. 

  • 次世代がん研究シーズ戦略的育成プログラム課題プログラムオフィサー

    Role(s): Review, evaluation

    国立研究開発法人日本医療研究開発機構  2015.4 - 2016.3

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第21回外科侵襲とサイトカイン研究会  ( 徳島 ) 2014.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第25回日本消化器癌発生学会総会  ( 福岡 ) 2014.11 - 2015.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第73回日本癌学会学術集会  ( 横浜 ) 2014.9 - 2015.9

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    Type:Competition, symposium, etc. 

  • サテライトシンポジスト

    第16回SNNS研究会  ( 鹿児島 ) 2014.9

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第52回日本癌治療学会学術集会  ( 横浜 ) 2014.8 - 2015.8

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第23回日本がん転移学会  ( 金沢 ) 2014.7 - 2015.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第23回日本癌病態治療研究会  ( 岐阜 ) 2014.6 - 2015.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第35回癌免疫外科研究会  ( 大阪 ) 2014.5 - 2015.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第114回日本外科学会定期学術集会  ( 京都 ) 2014.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第21回日本がん転移学会学術集会・総会  ( 広島 ) 2013.7

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第16回日本がん分子標的治療学会  ( 福岡 ) 2013.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第74回日本臨床外科学会総会  ( 東京 ) 2012.11 - 2012.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第71回日本癌学会学術総会  ( 札幌 ) 2012.9

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    Type:Competition, symposium, etc. 

  • 文部科学省 研究振興局 学術研究助成課  学術調査官

    Role(s): Review, evaluation

    文部科学省  2012.8 - 2014.7

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第112回日本外科学会  ( 千葉 ) 2012.4

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第70回日本癌学会  2011.10

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第51回日本消化器病学会  ( 京都国際会議場 ) 2009.10

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    2008.12 - 2010.11

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第66 回日本癌学会学術総会  2007.10 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第62回日本消化器外科学会  ( 東京大学大学院消化管外科学・上西紀夫教授・京王プラザホテル ) 2007.7 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本癌学会  ( 福岡 ) 2004.10 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    日本消化器外科学会  ( 鹿児島 ) 2004.7 - Present

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    Type:Competition, symposium, etc. 

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Research Projects

  • ヒトiPS技術を応用したヒト肝硬変モデルの構築と肝硬変の革新的治療法の開発

    Grant number:24K02523  2024 - 2028

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 空間的シングルセル解析による食道がん免疫寛容機構の解明とオミクスアプローチ

    Grant number:24K10384  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 前転移ニッチ構成細胞を標的にした大腸がん根治術後再発予防法の確立

    Grant number:24K11766  2024 - 2026

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 手術支援ロボットを用いた遠隔手術の実現に向けた実証研究

    Grant number:24hsa422001h0003  2024

    科学研究費助成事業  AMED 高度遠隔医療ネットワーク実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • オールジャパン体制による食道がん等消化器難治がんの全ゲノム配列データ及び臨床情報の収集・解析と創薬開発・全ゲノム医療基盤構築

    2023.4 - 2023.6

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    Authorship:Coinvestigator(s) 

  • 細胞内外エフェクターに対する大腸がん細胞の適応システムの包括的解析と新規免疫療法の開発

    Grant number:24jm0210108s0202  2023 - 2027

    科学研究費助成事業  AMED 医療分野国際科学技術共同研究開発推進事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • オールジャパン体制による食道がん等消化器難治がんの全ゲノム配列データ及び臨床情報による先端的創薬開発・全ゲノム医療基盤構築

    2023 - 2026

    科学研究費助成事業  AMED革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • メチル化ctDNAによる大腸がん根治術後再発早期診断の実装的モニタリング法の開発

    Grant number:23K06765  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 膵がん微小環境を構築する細胞社会において免疫寛容に寄与するがん代謝機構の解明

    Grant number:23K08215  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 転写産物のロングリード・シーケンスによる食道癌化学放射線療法抵抗性獲得機構の解明

    Grant number:23K07066  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 陥凹型早期癌のオルガノイドを用いた大腸癌浸潤・転移の再現と機序解明

    2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 空間的シングルセル解析による大腸腺腫から発がん過程に於ける免疫寛容獲得機構の解明

    Grant number:23K08074  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 時・空間的シングルセル解析による膵がん細胞の悪性度獲得機構の解明と治療標的の同定

    Grant number:22K08894  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • VISIUMによる乳がん転移阻害剤プロパゲルマニウムによる免疫能賦活化誘導機構の解明

    Grant number:23K06698  2023 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 個別化デジタルPCRによる超高感度腫瘍由来循環DNAモニタリング

    Grant number:23ck0106825h0001  2023 - 2025

    科学研究費助成事業  AMED革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 肝がんの分化規定遺伝子の同定と革新的治療法の開発(

    2022 - 2025

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 大腸がん細胞と共局在により悪性度と免疫寛容を獲得するがん微小環境の解明

    Grant number:22H02903  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 空間的シングルセル解析による大腸がん転移巣を形成するがん微小環境の解明

    2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 固形癌における抗腫瘍薬の薬剤耐性を改善するグルタミン代謝抑制化合物の開発

    Grant number:22K09006  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • タイプ別胃癌の誘因と発癌・進展における分子機序および免疫応答メカニズムの解明

    2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 空間的遺伝子発現解析を用いた食道癌CRT抵抗性に関わる免疫微小環境の検討

    Grant number:22K07774  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 肝内胆管癌多層オミックス解析と機械学習によるリポジショニング薬の同定

    Grant number:22K08826  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 難治性がんにおけるエピジェネティックな多様性・環境適応創生機構の解明に基づく新たな治療法開発

    2022 - 2024

    科学研究費助成事業  AMED次世代がん医療加速化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 膵がん組織内の腫瘍含有率を、デジタルPCRを用いたKRAS等変異アリル頻度から推定する研究

    2021.12 - 2023.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 遺伝子の臨床検体による層別化能の検証

    2021.8 - 2022.3

    共同研究

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    Authorship:Coinvestigator(s)  Grant type:Other funds from industry-academia collaboration

  • 大腸がんのハイリスク症例選別および早期発見における包括的 miRNA profileを用いたモニタリングシステムの構築と消化器癌における免疫チェックポイント阻害薬(ICI)抵抗性機構の解明

    2021.4 - 2026.3

    共同研究

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    Authorship:Principal investigator  Grant type:Other funds from industry-academia collaboration

  • 難治性消化器がんの前がん病変特異的な活性化エンハンサー領域/遺伝子の可視化と創薬標的となる特異的ゲノム変異の同定

    2021.4 - 2026.3

    九州大学 

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    Authorship:Principal investigator 

  • オールジャパン体制による食道がん等消化器難治がんの全ゲノム配列データ及び臨床情報の収集・解析と創薬開発・全ゲノム医療基盤構築

    Grant number:21ck0106690s0201  2021 - 2023

    科学研究費助成事業  AMED革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 難治がん特異的エピゲノム変異を標的にしたctDNA検出法の確立

    2020.6 - 2022.3

    九州大学 

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    Authorship:Principal investigator 

  • 大腸がん微小転移巣形成機構の理解による新規予防治療戦略の確立

    2020.4 - 2022.3

    金沢大学がん進展制御研究所 

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    Authorship:Coinvestigator(s) 

  • 国際共同研究に資する大規模日本人がんゲノム・オミックス・臨床データ統合解析とゲノム医療推進に向けた知識基盤構築

    2020.4 - 2022.3

    国立研究開発法人国立がん研究センター 研究所 

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    Authorship:Coinvestigator(s) 

  • 大腸がん微小転移巣形成機構の理解による新規予防治療戦略の確立

    2020 - 2023

    科学研究費助成事業  日本医療研究開発機構 革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 多領域シークエンスと進化シミュレーションによる大腸がん腫瘍内ダイバーシティの解明

    Grant number:20H05039  2020 - 2022

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究(研究領域提案型)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 国際共同研究に資する大規模日本人がんゲノム・オミックス・臨床データ統合解析とゲノム医療推進に向けた知識基盤構築

    Grant number:23ck0106800h0001  2020 - 2022

    科学研究費助成事業  日本医療研究開発機構 革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 難治がん特異的エピゲノム変異を標的にしたctDNA検出法の確立

    Grant number:20cm0106475h0001  2020 - 2021

    科学研究費助成事業  AMED次世代がん医療創生研究事業

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 公益財団法人武田科学振興財団 特定研究助成

    2020

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    Grant type:Donation

  • 大腸がん細胞の多段階悪性化が制御する微小環境形成ネットワーク機構の解明と新規予防治療戦略の確立

    2019.4 - 2022.3

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    Authorship:Coinvestigator(s) 

    本研究開発課題では、マウスモデルおよびヒト検体を用いた解析により、遺伝子変異の蓄積に基づく大腸がん細胞の悪性化機構を明らかにし、悪性化がん細胞による微小環境制御機構と、がん細胞と微小環境のネットワークが誘導するがん悪性化機構を解明する。それにより、ネットワーク関連因子を標的とする新規大腸がん予防・治療戦略を確立する。その目標達成のため、大腸がんの(1)多段階悪性化機構、(2)悪性化に伴う微小環境形成、(3)微小環境制御の分子機構、(4)免疫反応・抵抗性誘導、の4項目の研究を推進する。

  • 大腸初期病変から進行がんへの真の進化様式解明と治療法の確立

    Grant number:19H03715  2019 - 2021

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 公益財団法人鈴木謙三記念医科学応用研究財団 令和元年度調査研究助成

    2019

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    Grant type:Donation

  • 創薬標的分子の確かさを検証するツール物質の探索

    2018 - 2020

    科学研究費助成事業  AIP-PRISM

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 『大腸がん細胞の多段階悪性化が制御する微小環境形成ネットワーク機構の解明と新規予防治療戦略の確立』

    2017 - 2020

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 大腸がん症例の制御性T細胞の血液中バイオマーカーになるmicroRNAの同定

    Grant number:17K19608  2017 - 2018

    日本学術振興会  科学研究費助成事業  挑戦的研究(萌芽)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 微小環境多様性に連動する難治がんの分子遺伝学的多様性創成機構の解明と新たながん治療法・予測医療技術の開発

    2016.5 - 2022.3

    東京大学 

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    Authorship:Coinvestigator(s) 

  • 微少環境多様性に連動する難治がんの分子遺伝学的多様性創成機構の解明と新たながん治療法・予測医療技術の開発

    2016 - 2022

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 次世代がん医療創生研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 大規模ゲノム医療体制の確立と知識データベースの構築

    2016 - 2019

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 臨床ゲノム情報統合データベース整備事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 大腸がんの遺伝学的不均一性発生様式の生体時空間にわたるシステム的統合理解

    Grant number:16H01576  2016 - 2017

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 第30回ノバルティス研究奨励金 

    2016

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    Grant type:Donation

  • 公益財団法人 高松宮妃癌研究基金学術賞

    2016

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    Grant type:Donation

  • 公益財団法人細胞化学研究財団 国際交流助成

    2016

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    Grant type:Donation

  • トリプルネガティブ乳がんの転移後増殖をターゲットにした新規抗がん剤の開発

    2015.8 - 2016.3

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    Authorship:Principal investigator 

  • 食道癌の時空間的オミックス解析による進化と多様性の解明

    Grant number:15H04921  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 医師主導型治験『トリプルネガティブ乳がんの転移後増殖をターゲットとした新規抗がん剤の開発』

    2015 - 2017

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 新日本先進医療研究財団助成金

    2015

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    Grant type:Donation

  • 臨床検体の三次元的複層分子解析によるがん多様性創出機構の実証的解明とその克服に向けた臨床応用研究

    2014.4 - 2016.3

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    Authorship:Coinvestigator(s) 

  • 体液中マイクロRNA測定技術基盤開発

    2014.4 - 2016.3

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    Authorship:Coinvestigator(s) 

  • 『体液中マイクロRNA測定技術基盤開発』

    2014 - 2018

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 次世代治療・診断実現のための創薬基盤技術開発事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 『臨床検体の三次元的複層分子解析によるがん多様性創出機構の実証的解明とその克服に向けた臨床応用研究』

    2014 - 2016

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 膵癌症例の術後転移再発抑制を目差した慢性肝炎治療薬3−オキシゲルミルプロピオン酸重合体を用いた臨床治験に関する研究

    2014 - 2016

    科学研究費助成事業  国立研究開発法人日本医療研究開発機構 革新的がん医療実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 大腸前癌細胞において共役する異なる染色体由来の分子を標的とした治療法の確立

    Grant number:26670608  2014 - 2015

    科学研究費助成事業  挑戦的萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 公益財団法人安田記念医学財団 癌研究助成/食道癌全エキソン解析の結果による血中遊離DNA突然変異検出の臨床的意義

    2013

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    Grant type:Donation

  • 癌の再発・転移に関与するnon-coding RNAの同定とその機序解明

    2011.4 - 2014.3

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    Authorship:Principal investigator 

    これまでに大腸癌および胃癌症例の原発巣および骨髄を各分画(骨髄:癌細胞分画/単球分画/CD45分画/全血分画、原発巣癌細胞、転移巣癌細胞)に分け、RNAを抽出し、microRNAマイクロアレイ, mRNA マイクロアレイを行う系の確立を行った。現在のところ、大腸癌15例胃癌5例程度であるが、microRNA-遺伝子間におけるネットワーク、および癌細胞—ニッチ細胞間での連絡についての解析を進めている。
     われわれの目的は消化器癌の転移・再発のマーカーを明らかするには循環血液あるいは骨髄液中に癌細胞を検出することを目的とするのではなく、「癌細胞側因子」と「宿主側因子」とにおいて転移再発と明確な関連を有する因子を求めることにある。両面からの俯瞰的研究により、真の予測マーカーを求める。特に多くの遺伝子を一度に抑制しうるファインチューナーとしての役割を担うmicroRNAを含むnon coding RNAは、発現の臨床的意義が注目され、ncRNA-遺伝子pathwayの同定と機能解析が急がれる。
     若手研究S助成の際、各施設毎に倫理委員会を通過した後、消化器癌患者の骨髄と末梢血液の集積を開始した。骨髄は4つの分画(癌細胞分画、マクロファージ分画、CD45陽性分画、全血)に分けて、microRNAマイクロアレイおよび遺伝子マイクロアレイを施行する。転移陽性症例特異的miRについてはマーカーとしての意義を明らかにすることはもちろんのこと、標的遺伝子pathwayを決め、機能解析をすすめさらに絞り込めるマーカーを求める。
    <大腸癌症例>これまでに15例の症例に対して骨髄穿刺、末梢血採取を行った。Preliminaryに実施したDukes B,C8例のアレイを実施しいくつかの有力なmicroRNAを同定した。現在データの集計中である。

  • 革新的新規治療法開発 のための基盤創出-消 化器癌幹細胞と宿主細 胞の再プログラム-

    2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 17q25.1 領域の全転 写産物解析による食道 癌原因遺伝子の同定

    Grant number:23591937  2011 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 食道癌放射線治療成績 向上のための放射線感 受性制御micro RNAと遺伝子の解明

    2011 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • スーパーコンピュー ターを用いた大腸発 癌関連全因子の統合 的解析による発癌機 構の解明

    Grant number:23134505  2011 - 2012

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 癌の再発・転移に関与するnon-coding RNAの同定とその機序解明

    Grant number:LS094  2010 - 2013

    科学研究費助成事業  最先端・次世代研究支援プログラム助成

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    Authorship:Principal investigator  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 大規模症例における消化器癌転移メカニズムの網羅的・統合的解析

    Grant number:21249070  2009 - 2013

    日本学術振興会  科学研究費助成事業  基盤研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • マイクロRNAを介した消化器癌転移カスケードの解明

    Grant number:21679006  2009 - 2013

    科学研究費助成事業  若手研究(S)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 固形癌転移におけるmicroRNA profileの決定および重要なmiRNAの同定

    2008.7

    九州大学生体防御医学研究所外科(日本) 

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    Authorship:Principal investigator 

    消化器癌の転移・再発の成立においては、癌幹細胞と宿主側細胞とが転移形成に必須の新たな「転移巣社会」を形成すると推察されるため、両面から俯瞰的研究により転移再発機構を解明し、診断・治療の標的を求めることが重要である。このため、われわれは、平成17年度-19年度にわたり、『胃癌および大腸癌の骨髄・末梢血・リンパ節中における転移形成能を有する遊離癌細胞(Isolated Tumor Cell, ITC)の検出とその臨床応用に関する研究(九州大学 森 正樹 班長)』班を組織して、胃癌および大腸癌の転移機構の解明と真のマーカー同定のための研究を行ってきた。特に、癌細胞側の因子として、ごく最近注目されている「癌幹細胞」について、消化器癌からの分離同定を鋭意進めている。また骨髄中および末梢血液中に存在する癌細胞(各々disseminating tumor cell;DTCおよびcirculating tumor cell; CTC)をpan-CK抗体にて検出し、panCK陽性症例について原発巣のmicroarray解析を進めている。一方、宿主側因子としては、腹膜播種転移陽性胃癌患者の骨髄液と非転移胃癌患者の骨髄液よりtotal RNAを抽出し比較のためにmicroarrayを行い転移・再発を来す消化器癌症例において特異的に発現する遺伝子群を明らかにした。特に骨髄中造血幹細胞に存在することが報告された既知の遺伝子群についてその発現の臨床的意義を明らかにし報告した(Br J Cancer 2007, Clin Cancer Res 2008, Ann Surg Oncol 2008, Clin Cancer Res 2008)。
     したがって、新たな分子標的治療の真のマーカーを世界に先駆けて同定することと、多数の症例を用いて検証し確信をえることは、転移・再発機構を解明のみではなく、転移再発の診断、治療を行う上で極めて重要である。ごく最近、数十塩基のタンパク質をコードしていないRNAが,microRNA(miRNA)として働き,遺伝子発現調節をしていることが明らかになってきた。Weinbergらは原発巣におけるmiR10bが転移を制御することを明らかにしたが、消化器癌骨髄中において存在するmicro RNAと転移・予後との関係については明らかにされていない。

  • オハイオ癌研究所 カルロクローチェ研究室における特別講演および第61回米国腫瘍外科学会における発表について

    2008

    がん特定領域研究国際学術研究交流委員会

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    Authorship:Principal investigator  Grant type:Contract research

  • FHIT関連分子機構解明による食道発癌ハイリスク症例検出法の確立

    2008

    第35回かなえ医薬振興財団研究助成金

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    Authorship:Principal investigator  Grant type:Contract research

  • 癌患者の骨髄・末血中における遺伝子発現解析よりみた転移機構の解明

    Grant number:19390336  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • かなえ医薬振興財団研究奨励

    2007

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    Grant type:Donation

  • 慢性炎症により生じる消化器癌幹細胞を標的とした治療法の開発

    Grant number:18015039  2006 - 2007

    科学研究費助成事業  特定領域研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 悪臭を伴う進行皮膚露出乳癌に対する消臭および抗腫瘍治療の開発

    Grant number:16659337  2004 - 2005

    科学研究費助成事業  萌芽研究

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 癌治療の障壁となる癌の多様性の遺伝学的解明

    Grant number:16390381  2004 - 2005

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 膵癌症例に対する癌抑制遺伝子FHITによる遺伝子治療

    2004

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    Grant type:Donation

  • 癌抑制遺伝子FHITのカスケード解析と癌遺伝子治療法の確立

    Grant number:15390379  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 癌の外科治療を困難にしている癌細胞の多様性をひきおこす遺伝子群の解明

    Grant number:14370358  2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • p27制御因子Skp2の消化器癌・乳癌における臨床的意義

    Grant number:14570149  2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • DNA MicroarrayおよびLaser Microdissectionを用いた癌抑制遺伝子FHITの癌化と癌進展における役割の解明

    2002

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    Grant type:Donation

  • 上原研究奨励賞

    2002

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    Grant type:Donation

  • 「癌における微小転移(micrometastasis)の診断及び治療適応に関する研究」班

    2001 - 2004

    科学研究費助成事業  厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Competitive funding other than Grants-in-Aid for Scientific Research

  • 新しいタイプの癌抑制遺伝子であるFHIT遺伝子の機能解析と癌遺伝子治療への展開

    Grant number:134470239  2001 - 2002

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

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Educational Activities

  • Annual lectures for graduate students in Kyushu University.
    Contributing to the completion of degrees among the department's medical staff.

Class subject

  • 臨床腫瘍学の基本

    2020.4 - 2020.9   First semester

  • 臨床腫瘍学の基本

    2019.4 - 2019.9   First semester

  • 臨床腫瘍学の基本

    2018.4 - 2018.9   First semester

  • 臨床腫瘍医の基本

    2015.4 - 2015.9   First semester

  • 臨床腫瘍医の基本

    2013.4 - 2013.9   First semester

  • 臨床腫瘍医の基本原則と心理社会的側面

    2012.4 - 2012.9   First semester

  • 分子生物学

    2008.4 - 2008.9   First semester

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Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2019  立命館アジア太平洋大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:秋期セメスター 9月~1月 免疫学一般

  • 2018  立命館アジア太平洋大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:秋期セメスター 9月~1月 免疫学一般

  • 2017  立命館アジア太平洋大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:秋期セメスター 9月~1月 免疫学一般

  • 2016  立命館アジア太平洋大学  Classification:Part-time lecturer  Domestic/International Classification:Japan 

    Semester, Day Time or Duration:秋期セメスター 9月~1月 免疫学一般

Other educational activity and Special note

  • 2008  Class Teacher 

Outline of Social Contribution and International Cooperation activities

  • 2012-13: 28 Small Lectures in community centers in Beppu city

    2016.11.14 The 1st Remote Lecture for Ritsumeikan Asia Pacific University(APU)   “a real and vivid information” by native foreign doctors coming from abroad. The first communicator was Dr. Mohamed who gave a great talk entitled “Health issues, morbidity and mortality in Egypt”. We have learned and moved actual life of people in Egypt from what he insisted in his talk rather than the general knowledge of Egypt. This communication was really significant one for us. We have six intercollegiate meetings

Social Activities

  • 九大別府病院における治療の最前線

    九州大学病院別府病院  九州大学病院別府病院  2024.5

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 東部地域医療構想調整会議委員

    2024

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    東部地域医療構想調整会議委員

  • タイトル「がんの最新の情報」

    別府市自治体  別府市内公民館  2017.12

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 大腸癌、胃癌、乳癌に関する講演と健診の啓蒙活動

    別府市自治体  別府市内公民館  2017.9

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • がんにならないための10か条

    由布市地域保健委員会  湯布院福祉センター 大会議室   2015.7

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 2012年6月から別府市各自治会において、大腸癌、胃癌、乳癌に関する講演と健診の啓蒙活動

    別府市各自治体  別府市内公民館等  2015.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 2012年6月から別府市各自治会において、大腸癌、胃癌、乳癌に関する講演と健診の啓蒙活動

    別府市各自治会  別府市内公民館等  2014.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 2012年6月から別府市各自治会において、大腸癌、胃癌、乳癌に関する講演と健診の啓蒙活動

    別府市各自治会  別府市内公民館等  2013.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 2012年6月から別府市各自治会において、大腸癌、胃癌、乳癌に関する講演と健診の啓蒙活動

    別府市各自治会  別府市の各公民館等  2012.6

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

  • 別府市医師会理事

    2011

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    別府市医師会理事

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Media Coverage

  • 眺望を生かした理想の医療環境が実現 Newspaper, magazine

    九州医事新報社  2024.4

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    眺望を生かした理想の医療環境が実現

  • 質の高い医療提供を目指す Newspaper, magazine

    大分合同新聞  2024.1

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    質の高い医療提供を目指す

  • がん患者の遺伝子情報活用し継続支援 別府市スマートライフシティ計画初会合 「先進的な取り組み 有用性実証しよう」 Newspaper, magazine

    大分合同新聞  2017.11

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    がん患者の遺伝子情報活用し継続支援 別府市スマートライフシティ計画初会合
    「先進的な取り組み 有用性実証しよう」

  • かん患者の遺伝子情報活用 医療機関連携し治療 別府で実証実験 Newspaper, magazine

    大分合同新聞  2017.9

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    かん患者の遺伝子情報活用 医療機関連携し治療
    別府で実証実験

  • 九大病院別府病院、大分大、東大などの研究チーム スキルス胃がんの進行早める「播種」 原因遺伝子を特定 白血病治療薬が有効 Newspaper, magazine

    大分合同新聞  2016.3

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    九大病院別府病院、大分大、東大などの研究チーム
    スキルス胃がんの進行早める「播種」
    原因遺伝子を特定 白血病治療薬が有効

  • 九大病院別府病院と東大、阪大のチーム 大腸がんの進化メカニズム解明 多様な遺伝子変異で発症 進行暮らせる治療に応用へ Newspaper, magazine

    大分合同新聞  2016.3

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    九大病院別府病院と東大、阪大のチーム 大腸がんの進化メカニズム解明
    多様な遺伝子変異で発症 進行暮らせる治療に応用へ

  • 大腸がん進化過程を一部解明 九大病院別府病院と東大、阪大のチーム 治療への応用期待 スパコン「京」使い再現 Newspaper, magazine

    大分合同新聞  2016.2

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    大腸がん進化過程を一部解明
    九大病院別府病院と東大、阪大のチーム
    治療への応用期待 スパコン「京」使い再現

  • 県内の医療2015年 被ばく線量 ネットで管理 乳がん細胞光らせ可視化 Newspaper, magazine

    大分合同新聞  2015.12

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    県内の医療2015年
    被ばく線量 ネットで管理 乳がん細胞光らせ可視化

  • 「蛍光イメージ試薬による術中迅速微小乳がん検出の出現」論文の件 TV or radio program

    OBS  2015.7

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    「蛍光イメージ試薬による術中迅速微小乳がん検出の出現」論文の件

  • 乳がん細胞を可視化 Newspaper, magazine

    大分合同新聞  2015.7

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    乳がん細胞を可視化

  • 大分から成果 世界へ 乳がん細胞可視化で Newspaper, magazine

    大分合同新聞  2015.7

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    大分から成果 世界へ
    乳がん細胞可視化で

  • 「温泉浸かって高血圧予防」 別府市など調べ Newspaper, magazine

    産経新聞  2015.4

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    「温泉浸かって高血圧予防」
    別府市など調べ

  • 温泉と健康アンケート 九大病院が最終報告まとめる 助成の高血圧・喘息を予防 塩化物泉がうつ病防ぐ効果も Newspaper, magazine

    今日新聞  2015.3

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    温泉と健康アンケート 九大病院が最終報告まとめる
    助成の高血圧・喘息を予防
    塩化物泉がうつ病防ぐ効果も

  • がん進行 数式で予測 東大や九大、遺伝子異常に着目 転移防ぐ治療に道 Newspaper, magazine

    日本経済新聞  2014.3

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    がん進行 数式で予測
    東大や九大、遺伝子異常に着目 転移防ぐ治療に道

  • 大腸がんについて TV or radio program

    テレビ大分  2013.4

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    大腸がんについて

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Travel Abroad

  • 2023.5

    Staying countory name 1:Germany   Staying institution name 1:ISMRC

  • 2019.3

    Staying countory name 1:United States   Staying institution name 1:Ohio State University

  • 2013.3

    Staying countory name 1:United States   Staying institution name 1:MD Anderson

  • 2013.3

    Staying countory name 1:United States   Staying institution name 1:NIH

  • 2012.3

    Staying countory name 1:United States   Staying institution name 1:The Ohio State University College of Medicine

  • 2012.3

    Staying countory name 1:United States   Staying institution name 1:MD Anderson

  • 2011.3

    Staying countory name 1:United States   Staying institution name 1:The Ohio State University College of Medicine

  • 2011.3

    Staying countory name 1:United States   Staying institution name 1:MD Anderson

  • 2009.10

    Staying countory name 1:United States   Staying institution name 1:MDアンダーソン

  • 2005.2

    Staying countory name 1:Germany   Staying institution name 1:ハンブルグ大学

  • Staying countory name 1:United States   Staying institution name 1:オハイオ州立がんセンター

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Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Breast and Endocrine Surgery

  • Biology / Medicine, Dentistry and Pharmacy / Surgical Clinical Medicine / Gastrointestinal Surgery

Clinician qualification

  • 不明

    The Japan Society of Coloproctology

  • Preceptor

    The Japanese Society of Gastroenterological Surgery

  • Preceptor

    Japan Surgical Society(JSS)

  • Certifying physician

    Japanese Breast Cancer Society

  • 不明

    日本癌治療学会

  • 不明

    日本臨床外科学会

  • Certifying physician

    日本乳癌学会

  • corresponding member

    Society of Surgical Oncology

  • 評議員

    日本がん転移学会

  • 評議員

    日本消化器癌発生学会

  • 評議員

    日本癌学会

  • 不明

    日本胃癌学会

  • 不明

    日本食道学会

  • 不明

    日本臨床腫瘍学会

  • 不明

    日本癌病態治療研究会

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Year of medical license acquisition

  • 1991

Notable Clinical Activities

  • 別府市医師会理事に着任。医師会関係者との連携を密にしていきながら、別府市と九州大学との関係をさらに緊密にしていくべく鋭意努力をしております。とくに別府市が行う医療体系システム「ゆけむりネットワーク」は、現在市内の基幹病院で組織されておりますが、当院は残念ながらはいっておりません。近い将来的にこのシステムに組み込んでいただけるように努力をしていっております。  消化器外科では2010年から積極的に鏡視下手術を施行し、最近の半年では胃癌および大腸癌適応症例の9割以上に鏡視下手術を実施した。また、ヘルニア、直腸脱等の非癌症例に対しても積極的に導入している。さらに、乳腺外科においても当院における最新の放射線照射機器と医師スタッフの充実もあり、乳房温存手術を可能な限り行っている。  その他、地域に根差した基幹病院としての外科診療とトランスレーショナル・リサーチによる最先端医療の展開を両立させたいと考えています。近隣の基幹病院のみならず全国的にみても、標準治療を終えた高度進行癌患者いわゆる癌難民については、あまり積極的ではない傾向があり社会問題にもなっている。別府地区において最新の放射線照射機器と放射線治療専門医を有するのは当院のみであることから、別府病院の強みを生かした診療が重要であると考える。われわれは低侵襲手術患者のみならず、進行癌患者も集中的に集めることにより、「癌の治療に専心した診療科」として高度進行癌患者を対象に、サルベージ手術あるいは放射線照射を含めた集学的治療を再考するシステムを構築したいと考えている。外科治療、放射線治療、抗癌剤治療、免疫療法などの集学的療法に加えて緩和医療を含め、癌難民を救済することも別府地区において重要であり、現在推進中であります。 全別府市民を対象に、各自治体をまわり講演活動をおこない、医療・健康への啓蒙活動をおこなっている。また、近年、乳癌症例の数が多く、毎週金曜日に手術枠を増やして対応している。