Updated on 2025/06/18

写真a

 
NAKAMURA KEIJI
 
Organization
Kyushu University Hospital Center for the Study of Global Infection Assistant Professor
School of Medicine Department of Medicine(Concurrent)
Title
Assistant Professor
Profile
グローバル感染症センター・総合診療科として外来を2回/週(渡航外来、総合診療科外来)、病棟業務として、研修医・レジデントの指導、リスクマネージャーを行っている。また、2024年4月よりグローバル感染症センター併任としてICT/AST活動を行っている。教育研究については、学生に対する診療・感染対策指導、レクチャーを行っている。研究については、感染症をメインに行って行っている。定期的に学会発表や論文作成を行っている。

Research Areas

  • Life Science / Infectious disease medicine

Research History

  • Kyushu University Kyushu University Hospital Center for the Study of Global Infection / General Internal Medicine  Assistant Professor 

    2024.4 - Present

  • Kyushu University General Internal Medicine Assistant Professor 

    2021.4 - Present

Education

  • Yamaguchi University   医学部   医学科

    2006.4 - 2012.3

Research Interests・Research Keywords

  • Research theme: Clinical research in the field of infectious diseases

    Keyword: infectious diseases, COVID-19, bloodstream infection

    Research period: 2022.10

Papers

  • Clinical and virological features of SARS-CoV-2 Omicron variant-infected immunocompromised patients receiving immunosuppressive medications Reviewed

    Keiji Nakamura, Takeyuki Goto, Kenichiro Shiraishi, Akiko Yonekawa, Yoshihiro Eriguchi, Koichi Akashi, Nobuyuki Shimono, Yong Chong

    BMC infectious diseases   2024.7

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    Authorship:Lead author   Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12879-024-09633-1

  • Clinical outcomes and epidemiological characteristics of bacteremia in the older Japanese population. International journal

    Keiji Nakamura, Kayoko Hayakawa, Shinya Tsuzuki, Satoshi Ide, Hidetoshi Nomoto, Takato Nakamoto, Gen Yamada, Kei Yamamoto, Norio Ohmagari

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2023.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    BACKGROUND: The characteristics and clinical consequences of bacteremia in older people, who are highly susceptible to infections, need to be clarified. This study aimed to determine the epidemiological characteristics, prognosis, and predictors of 7-day mortality in patients with community-acquired (CA), healthcare-associated (HCA), and hospital-onset (HO) bacteremia in older adults aged ≥65 years. METHODS: Patients aged ≥65 years with positive blood cultures between April 1, 2015, and March 31, 2018, were divided into three groups: pre-old (65-74 years), old (75-89 years), and super-old (≥90 years). Characteristics based on medical exposure, including CA, HCA, and HO, were also compared and factors related to mortality were identified. RESULTS: Overall, 1716 episodes of bacteremia were identified in 1415 patients. Of the 1211 episodes without contamination, 32.8%, 54.3%, and 12.9% occurred in pre-old, old, and super-old patients. Central line-associated bloodstream infections were more common in pre-old patients and urinary tract infections in the old and super-old. The 7-day mortality rates in the pre-old, old, and super-old groups were 7.4%, 5.8%, and 14.2% (P = 0.002), respectively. Multivariable logistic regression showed that super-old age (adjusted odds ratio, aOR: 2.09 [1.13-3.88], P = 0.019) and HO bacteremia (aOR: 1.97 [1.18-3.28], P = 0.010) were independent risk factors for 7-day mortality. Infectious disease consultation had a protective effect on 7-day mortality (aOR: 0.59 [0.35-0.99], P = 0.047). CONCLUSIONS: The epidemiology of bacteremia differs among older people; thus, they should not be treated as a single entity. A careful approach is needed for the optimal management of bacteremia in these vulnerable patients.

    DOI: 10.1016/j.jiac.2023.06.015

  • Environmental surface and air contamination in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patient rooms by disease severity. International journal

    Keiji Nakamura, Shinichiro Morioka, Satoshi Kutsuna, Shun Iida, Tadaki Suzuki, Noriko Kinoshita, Tetsuya Suzuki, Yuko Sugiki, Ayako Okuhama, Kohei Kanda, Yuji Wakimoto, Mugen Ujiie, Kei Yamamoto, Masahiro Ishikane, Yuki Moriyama, Masayuki Ota, Takato Nakamoto, Satoshi Ide, Hidetoshi Nomoto, Yutaro Akiyama, Yusuke Miyazato, Kayoko Hayakawa, Sho Saito, Norio Ohmagari

    Infection prevention in practice   2 ( 4 )   100098 - 100098   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    Background: The coronavirus disease 2019 (COVID-19) continues to spread around the world. In addition to community-acquired infections, nosocomial infections are also a major social concern. The likelihood of environmental contamination and transmission of the virus based on disease severity is unknown. Methods: We collected nasopharyngeal, environmental and air samples from patients with COVID-19 admitted to the National Centre for Global Health and Medicine between January 29th and February 29th, 2020. The patients were classified by severity of disease. The collected samples were tested using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time reverse transcription polymerase chain reaction (real-time RT-PCR). Results: SARS-CoV-2 was not detected in a subset of 11 air samples. Of the 141 environmental samples collected from three patient bays and two single rooms, four samples tested positive for SARS-CoV-2 by real-time RT-PCR. Detections were made on the surface of a stethoscope used in the care of a patient with severe disease, on the intubation tube of a patient classified as critical (and on ventilator management), and on the surface of a gown worn by the nurse providing care. Conclusions: Regardless of the patients' disease severity, SARS-CoV-2 was detected on very few environmental surfaces. However, detection of SARS-CoV-2 on stethoscopes used in the care of multiple patients and on the surface of gowns worn by clinical staff indicates that medical devices may be linked to the spread of infection.

    DOI: 10.1016/j.infpip.2020.100098

  • Clinical performance testing of the automated haematology analyzer XN-31 prototype using whole blood samples from patients with imported malaria in Japan Invited Reviewed International journal

    Kanako Komaki-Yasuda, Satoshi Kutsuna, Miki Kawaguchi, Mina Kamei, Kinya Uchihashi, Keiji Nakamura, Takato Nakamoto, Norio Ohmagari, Shigeyuki Kano

    Malaria Journal   2022.6

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

  • Direct hemoperfusion using a polymyxin B-immobilized polystyrene column for COVID-19. International journal

    Daisuke Katagiri, Masahiro Ishikane, Yusuke Asai, Shinyu Izumi, Jin Takasaki, Hiyori Katsuoka, Isao Kondo, Satoshi Ide, Keiji Nakamura, Takato Nakamoto, Hidetoshi Nomoto, Yutaro Akiyama, Yusuke Miyazato, Tetsuya Suzuki, Noriko Kinoshita, Tatsunori Ogawa, Tomiteru Togano, Manabu Suzuki, Masao Hashimoto, Keita Sakamoto, Yusaku Kusaba, Takashi Katsuno, Takashi Fukaya, Masayuki Hojo, Masaya Sugiyama, Masashi Mizokami, Tatsuya Okamoto, Akio Kimura, Eisei Noiri, Norio Ohmagari, Fumihiko Hinoshita, Haruhito Sugiyama

    Journal of clinical apheresis   36 ( 3 )   313 - 321   2021.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    OBJECTIVE: To evaluate the efficacy and safety of direct hemoperfusion using a polymyxin B-immobilized polystyrene column (PMX-DHP) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pneumonia patients. METHODS: This study was a case series conducted at a designated infectious diseases hospital. Twelve SARS-CoV-2-positive patients with partial pressure of arterial oxygen/percentage of inspired oxygen (P/F) ratio < 300 were treated with PMX-DHP on two consecutive days each during hospitalization. We defined day 1 as the first day when PMX-DHP was performed. PMX-DHP efficacy was assessed on days 7 and 14 after the first treatment based on eight categories. Subsequently, improvement in P/F ratio and urinary biomarkers on days 4 and 8, malfunctions, and ventilator and extracorporeal membrane oxygenation avoidance rates were also evaluated. RESULTS: On day 14 after the first treatment, disease severity decreased in 58.3% of the patients. P/F ratio increased while urine β2-microglobulin decreased on days 4 and 8. Cytokine measurement pre- and post-PMX-DHP revealed decreased levels of interleukin-6 and the factors involved in vascular endothelial injury, including vascular endothelial growth factor. Twenty-two PMX-DHPs were performed, of which seven and five PMX-DHPs led to increased inlet pressure and membrane coagulation, respectively. When the membranes coagulated, the circuitry needed to be reconfigured. Circuit problems were usually observed when D-dimer and fibrin degradation product levels were high before PMX-DHP. CONCLUSIONS: Future studies are expected to determine the therapeutic effect of PMX-DHP on COVID-19. Because of the relatively high risk of circuit coagulation, coagulation capacity should be assessed beforehand.

    DOI: 10.1002/jca.21861

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Books

  • グローバル感染症マニュアル 改定第2版

    Role:Contributor急性下痢症)

    南江堂  2024.12 

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    Language:Japanese   Book type:Textbook, survey, introduction

  • 発熱性好中球減少症(FN)診療ガイドライン 改訂第3版

    Role:Contributor)

    南江堂  2024.2 

  • 【診療力を上げる! 症例問題集】(第5章)感染症 症例問題 3日前からの咽頭痛,2日前からの発熱・鼻汁を主訴に受診した41歳男性

    中村 啓二, 石金 正裕

    内科  2019.4 

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    Responsible for pages:Vol.123, No.4, pp.741-743   Language:Japanese  

Presentations

  • がん薬物療法を行う患者における帯状疱疹ワクチンの必要性と問題点 Invited

    中村 啓二, @高田 徹

    第21回 臨床腫瘍学会  2024.2 

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    Event date: 2024.2

    Language:Japanese  

    Country:Japan  

  • 固形臓器移植及び造血幹細胞移植 患者における SARS-CoV-2 PCR Ct 値の変化

    中村啓二, 後藤健志, 白石研一郎, 谷 直樹, 米川晶子, 池崎裕昭, 髙山耕治,村田昌之, 鄭 湧, 下野信行

    第93回日本感染症学会西日本地方会  2023.11 

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    Event date: 2023.11

    Language:Japanese  

    Country:Japan  

  • Clinical outcomes and epidemiological characteristics of bacteremia in the older population of Japan

    Keiji Nakamura, Kayoko Hayakawa, MD, PhD, Shinya Tsuzuki, MD, MSc, Satoshi Ide, Hidetoshi Nomoto, Takato Nakamoto, Gen Yamada, Kei Yamamoto, Norio Ohmagari, MD, MSc, PhD

    ID week 2021  2021.10 

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    Event date: 2021.10

    Language:English   Presentation type:Oral presentation (general)  

    Country:United States  

  • 30年以上経過して活性化したMycobacterium tuberculosis var. BCGによる左腋窩リンパ節炎の慢性肉芽腫症成人例

    中村 啓二, 中本 貴人, 木下 典子, 高崎 仁, 忽那 賢志, 早川 佳代子, 大楠 清文, 大曲 貴夫

    第95回日本感染症学会学術講演会  2021.4 

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    Event date: 2021.4

    Language:Japanese   Presentation type:Oral presentation (general)  

    Country:Japan  

  • 持ち込みタオルからBacillus cereus菌血症を発症し医療者を介して水平感染が疑われた症例の検討

    中村啓二、鎗水彰、居原毅、澤山泰典、石丸敏之

    第90回日本感染症学会学術講演会  2016.4 

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    Event date: 2016.4

    Language:Japanese   Presentation type:Poster presentation  

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MISC

  • Bloodstream infections in the elderly Japanese population: Current reality and countermeasures Reviewed

    Keiji Nakamura, Kayoko Hayakawa, Shinya Tsuzuki, Norio Ohmagari

    Global Health & Medicine   2024;6 ( 1 )   90 - 92   2024.2

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    Authorship:Lead author   Language:English   Publishing type:Rapid communication, short report, research note, etc. (scientific journal)  

    DOI: 10.35772/ghm.2023.01109

  • Infection with capsular genotype K1-ST23 hypervirulent Klebsiella pneumoniae isolates in Japan after a stay in East Asia: Two cases and a literature review.

    Keiji Nakamura, Hidetoshi Nomoto, Sohei Harada, Masahiro Suzuki, Keina Yomono, Ritsuko Yokochi, Noboru Hagino, Takato Nakamoto, Yuki Moriyama, Kei Yamamoto, Satoshi Kutsuna, Norio Ohmagari

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   2021.10

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    Language:English  

    Disseminated community-acquired infections caused by the hypervirulent Klebsiella pneumoniae (hvKp) among relatively healthy individuals in East Asia have been reported in recent years. Isolate of the capsular genotype K1, belonging to sequence type (ST) 23, is the most common causative agent of this disease. We experienced two cases of K1-ST23 infection with a travel history in East Asia, and hvKp infection was diagnosed after entering or returning to Japan. Case 1 was a 45-year-old Myanmar seaman with a history of ischemic heart disease who developed a fever on board and was transported to Japan via Shanghai and Taiwan. He had multiple disseminated lesions due to K. pneumoniae; other symptoms included liver abscess, intraocular inflammation, intraventricular thrombosis, brain abscess, and bloodstream infection. Along with antimicrobial treatment, drainage of liver abscesses and surgery for intraocular inflammation and intraventricular thrombosis were required. The patient was discharged 93 days after admission, with little improvement in the visual acuity. Case 2: A 29-year-old Japanese man with no underlying disease developed a prostate abscess and bloodstream infection caused by K. pneumoniae after a trip to Korea. However, he improved only with antimicrobial treatment. K. pneumoniae in both cases were identified to have the rmpA gene, with capsular genotypes K1 and ST23. Further, both cases were considered to have been infected with hvKp during their stay in East Asia. In conclusion, it is important to suspect disseminated disease and perform a systemic search, taking into account that hvKp may be present in cases of Klebsiella infection acquired from East Asia.

    DOI: 10.1016/j.jiac.2021.05.011

  • COVID-19 can suddenly become severe: a case series from Tokyo, Japan.

    Keiji Nakamura, Satoshi Ide, Sho Saito, Noriko Kinoshita, Satoshi Kutsuna, Yuki Moriyama, Tetsuya Suzuki, Masayuki Ota, Hidetoshi Nomoto, Tetsuya Mizoue, Masayuki Hojo, Jin Takasaki, Yusuke Asai, Mari Terada, Yutaro Akiyama, Yusuke Miyazato, Takato Nakamoto, Yuji Wakimoto, Mugen Ujiie, Kei Yamamoto, Masahiro Ishikane, Shinichiro Morioka, Kayoko Hayakawa, Haruhito Sugiyama, Norio Ohmagari

    Global health & medicine   2020.6

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    Language:English  

    Since the initial report of coronavirus disease (COVID-19) from the City of Wuhan, China in December 2019, there have been multiple cases globally. Reported here are 11 cases of COVID-19 at this hospital; all of the patients in question presented with relative bradycardia. The severity of the disease was classified into four grades. Of the patients studied, 3 with mild COVID-19 and 3 with moderate COVID-19 improved spontaneously. Lopinavir/ ritonavir was administered to 3 patients with severe COVID-19 and 2 with critical COVID-19. Both patients with critical COVID-19 required mechanical ventilation and extracorporeal membrane oxygenation. Both patients with critical COVID-19 had a higher fever that persisted for longer than patients with milder COVID-19. The respiratory status of patients with critical COVID-19 worsened rapidly 7 days after the onset of symptoms. Relative bradycardia may be useful in distinguishing between COVID-19 and bacterial community-acquired pneumonia. In patients who have had a fever for > 7 days, the condition might worsen suddenly.

    DOI: 10.35772/ghm.2020.01054

  • A case of severe COVID-19 with pulmonary thromboembolism related to heparin-induced thrombocytopenia during prophylactic anticoagulation therapy Reviewed

    Kosaku Sasaki, Masayuki Murata, Keiji Nakamura, Yuji Matsumoto, Yuko Nakashima, Sho Yamasaki, Azusa Ota, Satoshi Hiramine, Koji Takayama, Hiroaki Ikezaki, Kazuhiro Toyoda, Eiichi Ogawa, Nobuyuki Shimono

    Journal of Infection and Chemotherapy   2022.8

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    Language:Japanese  

  • Positive Ratio of Polymerase Chain Reaction (PCR) and Validity of Pre-Screening Criteria at an Outpatient Screening Center during the Early Phase of the COVID-19 Epidemic in Japan.

    Satoshi Ide, Kayoko Hayakawa, Kei Yamamoto, Shinya Tsuzuki, Junko Tanuma, Kaori Ohara, Gen Yamada, Ayako Okuhama, Kohei Kanda, Tetsuya Suzuki, Yutaro Akiyama, Yusuke Miyazato, Keiji Nakamura, Hidetoshi Nomoto, Takato Nakamoto, Mugen Ujiie, Sho Saito, Shinichiro Morioka, Masahiro Ishikane, Noriko Kinoshita, Satoshi Kutsuna, Keiko Tanaka, Norio Ohmagari

    Japanese journal of infectious diseases   2021.9

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    Language:English  

    Despite the increase in COVID-19 cases globally, the number of cases in Japan has been relatively low, and an explosive surge in the prevalence has not occurred. In March 2020, the Ministry of Health, Labour and Welfare (MHLW) in Japan recommended the original criteria for polymerase chain reaction (PCR) testing, although there was a lack of evidence for appropriate targets for COVID-19 testing. This study aimed to evaluate the COVID-19 positive ratio and pre-screening criteria in Tokyo immediately after the insurance-covered SARS-CoV-2 PCR testing became available in Japan. We subjected 277 individuals with mild symptoms in metropolitan Tokyo (positive: 9.0&#37;) from March 9 to 29, 2020, to SARS-CoV-2 PCR testing. The results revealed that 25 (9.0&#37;) of them were PCR-positive. The sensitivity and specificity of the MHLW criteria were 100&#37; and 10.7&#37;, respectively. When the criteria excluded nonspecific symptoms, fatigue, and dyspnea, the sensitivity slightly decreased to 92&#37;, and the specificity increased to 22.2&#37;. The specificity was highest when the fever criterion was ≥37.5°C for ≥4 days, and exposure/travel history, including age and underlying comorbidities, was considered. Our findings suggest that the MHLW criteria, including the symptoms and exposure/travel history, may be useful for COVID-19 pre-screening.

    DOI: 10.7883/yoken.JJID.2020.813

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Professional Memberships

  • 日本内科学会

  • 日本感染症学会

  • 日本環境感染学会

Educational Activities

  • 医学部医学科4, 5, 6年生の臨床実習や講義、感染対策指導、医学部医学科学生のOSCEの指導を担当している。

Class subject

  • クリニカルクラークシップ

    2024.4 - 2025.3   Full year

  • 臨床実習

    2024.4 - 2025.3   Full year

  • 臨床実習1

    2023.4 - 2024.3   Full year

  • クリニカルクラークシップ

    2023.4 - 2023.9   First semester

  • 臨床実習1

    2022.4 - 2023.3   Full year

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Clinical Internal Medicine / Collagen Disease, Allergy, Infectious Disease Internal Medicine

Clinician qualification

  • Preceptor

    The Japanese Association for Infectious Diseases

  • Specialist

    The Japanese Association for Infectious Diseases

  • Specialist

    The Japanese Society of Internal Medicine(JSIM)

Year of medical license acquisition

  • 2012

Notable Clinical Activities

  • 院内の感染対策、感染症患者診療を行っている。COVID-19患者やCOVID-19後の後遺症外来診療を行っている。