Evaluation of appropriate conditions for Oncomine DxTT testing of FFPE specimens for driver gene alterations in non-small cell lung cancer Invited Reviewed International journal

Eiji Iwama, Hidetaka Yamamoto, Fumihiko Okubo, Kayo Ijichi, Ritsu Ibusuki, Yoshimasa Shiaraishi, Yasuto Yoneshima, Kentaro Tanaka, Yoshinao Oda, Isamu Okamoto

Thorac Cancer   2023.8

Tumor Microenvironment Landscape of NSCLC Reveals Resistance Mechanisms for Programmed Death-Ligand 1 Blockade After Chemoradiotherapy: A Multicenter Prospective Biomarker Study (WJOG11518L:SUBMARINE) Reviewed International journal

Koji Haratani, Atsushi Nakamura, Nobuaki Mamesaya, Shigeki Mitsuoka, Yasuto Yoneshima, Ryota Saito, Junko Tanizaki, Yasuhito Fujisaka, Akito Hata, Kosuke Tsuruno, Tomohiro Sakamoto, Shunsuke Teraoka, Masahide Oki, Hiroshi Watanabe, Yuki Sato, Yusuke Nakano, Tomoyuki Otani, Kazuko Sakai, Shuta Tomida, Yasutaka Chiba, Akihiko Ito, Kazuto Nishio, Nobuyuki Yamamoto, Kazuhiko Nakagawa, Hidetoshi Hayashi

Journal Thoracic Oncology   2023.8

Carboplatin and irinotecan (CI) vs. carboplatin and etoposide (CE) for the treatment of extended-stage small-cell lung cancer in an elderly population: A phase II/III randomized control trial Reviewed International journal

Tsuneo Shimokawa, Hiroaki Okamoto, Ryunosuke Machida, Yuki Misumi, Yukio Hosomi, Yasuto Yoneshima, Hiroshi Tanaka, Kyoichi Okishio, Junichi Simizu, Koichi Goto, Hiroaki Akamatsu, Kaoru Kubota, Kazuhiko Nakagawa, Hidehito Horinouchi, Masahiko Ando, Tomoko Kataoka, Yuichiro Ohe

Lung Cancer   2023.7

TROPION-Lung08: phase III study of datopotamab deruxtecan plus pembrolizumab as first-line therapy for advanced NSCLC Reviewed International journal

Benjamin P Levy, Enriqueta Felip, Martin Reck, James Ch Yang, Federico Cappuzzo, Yasuto Yoneshima, Caicun Zhou, Siddhartha Rawat, Jingdong Xie, Priyanka Basak, Lu Xu, Jacob Sands

Future Oncology   2023.7

Regulation of PD-L1 expression in non-small cell lung cancer by interleukin-1β Reviewed International journal

2023.6

Gumarontinib in patients with non-small-cell lung cancer harbouring MET exon 14 skipping mutations: a multicentre, single-arm, open-label, phase 1b/2 trial Reviewed International journal

Yongfeng Yu, Jianya Zhou, Xingya Li, Koichi Goto, Xuhong Min, Kazumi Nishino, Jiuwei Cui, Lin Wu, Jun Sakakibara, Yongqian Shu, Xiaorong Dong, Lu Li, Yasuto Yoneshima, Chengzhi Zhou, Xiaoling Li, Yiping Zhang, Dingzhi Huang, Aimin Zang, Wei Zhang, Xiuwen Wang, Li Zhang, Chong Bai, Jian Fang, Lejie Cao, Yanqiu Zhao, Yan Yu, Meiqi Shi, Diansheng Zhong, Fugen Li, Meng Li, Qiuxia Wu, Jun Zhou, Minghui Sun, Shun Lu

2023.4

Immunostimulatory oncolytic activity of coxsackievirus A11 in human malignant pleural mesothelioma Reviewed International journal

Okamura Koji, Inoue Hiroyuki, Tanaka Kentaro Ikematsu Yuki, Furukawa Rie Ota Keiichi, Yoneshima Yasuto, Iwama Eiji, Okamoto Isamu

CANCER SCIENCE   114 ( 3 )   1095 - 1107   2023.3

Sotorasib versus docetaxel for previously treated non-small-cell lung cancer with KRASG12C mutation: a randomised, open-label, phase 3 trial Reviewed International journal

Lancet   2023.2

Nab-Paclitaxel for Previously Treated Advanced Non-Small Cell Lung Cancer: Analysis of Safety and Efficacy for Patients With Renal Impairment Reviewed International journal

@Yasuto Yoneshima, Satoshi Morita, Masahiko Ando, Atsushi Nakamura, Shunichiro Iwasawa, Hiroshige Yoshioka, Yasuhiro Goto, Masafumi Takeshita, Toshiyuki Harada, Katsuya Hirano, Tetsuya Oguri, Masashi Kondo, Satoru Miura, Yukio Hosomi, Terufumi Kato, Toshio Kubo, @Junji Kishimoto, Nobuyuki Yamamoto, @Yoichi Nakanishi, @Isamu Okamoto

CLINICAL LUNG CANCER   23 ( 7 )   585 - 592   2022.11

Association of thyroid transcription factor-1 (TTF-1) expression with efficacy of PD-1/PD-L1 inhibitors plus pemetrexed and platinum chemotherapy in advanced non-squamous non-small cell lung cancer Reviewed International journal

#Ritsu Ibusuki, @Yasuto Yoneshima, @Mikiko Hashisako, Norikazu Matsuo, Taishi Harada, Yuko Tsuchiya-Kawano, @Junji Kishimoto, @Keiichi Ota, @Yoshimasa Shiraishi, @Eiji Iwama, @Kentaro Tanaka, @Yoshinao Oda, @Isamu Okamoto

TRANSLATIONAL LUNG CANCER RESEARCH   2022.9

Quantification of HER family dimers by proximity ligation assay and its clinical evaluation in non-small cell lung cancer patients treated with osimertinibRenpeng Liu 1, Keiichi Ota 2, Eiji Iwama 1, Yasuto Yoneshima 1, Kentaro Tanaka 1, Hiroyuki Inoue 3, Tetsuzo Tagawa 4, Yoshinao Oda 5, Masaki Mori 4, Yoichi Nakanishi 6, Isamu Okamoto Reviewed International journal

#Renpeng Liu, @Keiichi Ota, @Eiji Iwama, @Yasuto Yoneshima, @Kentaro Tanaka, @Hiroyuki Inoue, @Tetsuzo Tagawa, @Yoshinao Oda, @Masaki Mori, @Yoichi Nakanishi, @Isamu Okamoto

Lung Cancer   158   156 - 161   2022.6

A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study Reviewed International journal

Kazuki Takada 1, Mototsugu Shimokawa 2 3, Shinkichi Takamori 4, Shinichiro Shimamatsu 5, Fumihiko Hirai 5, Tetsuzo Tagawa 6, Tatsuro Okamoto 7, Motoharu Hamatake 5, Yuko Tsuchiya-Kawano 8, Kohei Otsubo 8, Koji Inoue 8, Yasuto Yoneshima 9, Kentaro Tanaka 9, Isamu Okamoto 9, Yoichi Nakanishi 8, Masaki Mori 6

BMC Cancer   22 ( 1 )   503   2022.6

A propensity score-matched analysis of the impact of statin therapy on the outcomes of patients with non-small-cell lung cancer receiving anti-PD-1 monotherapy: a multicenter retrospective study Reviewed International journal

Kazuki Takada, Mototsugu Shimokawa, Shinkichi Takamori, Shinichiro Shimamatsu, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Motoharu Hamatake, Yuko Tsuchiya-Kawano, Kohei Otsubo, Koji Inoue, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Yoichi Nakanishi, Masaki Mori

BMC Cancer   22 ( 1 )   503   2022.6

Randomized phase II study of osimertinib plus bevacizumab versus osimertinib for untreated patients with non-squamous non-small cell lung cancer harboring EGFR mutations; WJOG9717L study Reviewed International journal

Hirotsugu Kenmotsu, Kazushige Wakuda, Keita Mori, Terufumi Kato, Shunichi Sugawara, Keisuke Kirita, @Yasuto Yoneshima, Koichi Azuma, Kazumi Nishino, Shunsuke Teraoka, Takehito Shukuya, Ken Masuda, Hidetoshi Hayashi, Ryo Toyozawa, Satoru Miura, Daichi Fujimoto, Kazuhiko Nakagawa, Nobuyuki Yamamoto, Toshiaki Takahashi

Journal of Thoracic Oncology   2022.5

Phase 3 Trial Comparing Nanoparticle Albumin-Bound Paclitaxel With Docetaxel for Previously Treated Advanced NSCLC Reviewed International journal

@Yasuto Yoneshima, Satoshi Morita, Masahiko Ando, Atsushi Nakamura, Shunichiro Iwasawa, Hiroshige Yoshioka, Yasuhiro Goto, Masafumi Takeshita, Toshiyuki Harada, Katsuya Hirano, Tetsuya Oguri, Masashi Kondo, Satoru Miura, Yukio Hosomi, Terufumi Kato, Toshio Kubo, @Junji Kishimoto, Nobuyuki Yamamoto, @Yoichi Nakanishi, @Isamu Okamoto

Journal of Thoracic Oncology   16 ( 9 )   1523 - 1532   2021.9

Clinical impact of probiotics on the efficacy of anti-PD-1 monotherapy in patients with nonsmall cell lung cancer: A multicenter retrospective survival analysis study with inverse probability of treatment weighting Reviewed International journal

Kazuki Takada, Mototsugu Shimokawa, Shinkichi Takamori, Shinichiro Shimamatsu, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Motoharu Hamatake, Yuko Tsuchiya-Kawano, Kohei Otsubo, Koji Inoue, @Yasuto Yoneshima, @Kentaro Tanaka, @Isamu Okamoto, @Yoichi Nakanishi, @Masaki Mori

International Journal of Cancer   149 ( 2 )   473 - 482   2021.7

HTLV-1 seropositive patients with lung cancer treated with PD-1 inhibitors Invited Reviewed International journal

Y@asuto Yoneshima, @Koji Kato, @Haruna Minami, @Munehiko Ikeda, @Hiroyuki Watanabe, @Goichi Yoshimoto, @Toshihiro Miyamoto, @Koichi Akashi, @Yoichi Nakanishi, @Isamu Okamoto

Cancer Sci.   2021.6

Paired analysis of tumor mutation burden for lung adenocarcinoma and associated idiopathic pulmonary fibrosis Reviewed International journal

@Yasuto Yoneshima, @Eiji Iwama, Shingo Matsumoto, Taichi Matsubara, Testuzo Tagawa, @Keiichi Ota, @Kentaro Tanaka, Mitsuhiro Takenoyama, Tatsuro Okamoto, Koichi Goto, @Masaki Mori, @Isamu Okamoto

Scientific Reports   11 ( 1 )   12732   2021.6

Prognostic impact of primary cancer adjoining emphysematous bullae in non-small cell lung cancer patients treated with immune checkpoint inhibitors Reviewed International journal

Shinkichi Takamori, Kazuki Takada, Mototsugu Shimokawa, Mikako Jinnnouchi, Taichi Matsubara, Naoki Haratake, Naoko Miura, Ryo Toyozawa, Masafumi Yamaguchi, Mitsuhiro Takenoyama, @Yasuto Yoneshima, @Kentaro Tanaka, @Isamu Okamoto, Tetsuzo Tagawa, @Masaki Mori

Cancer Immunology, Immunotherapy   70 ( 6 )   1745 - 1753   2021.6

Increased plasma levels of damage-associated molecular patterns during systemic anticancer therapy in patients with advanced lung cancer Invited Reviewed International journal

@Hiroyuki Inoue, #Hirono Tsutsumi, @Kentaro Tanaka, @Eiji Iwama, @Yoshimasa Shiraishi, #Aiko Hirayama, #Takayuki Nakanishi, #Hiroyuki Ando, #Maako Nakajima, #Seiji Shinozaki, #Hiroaki Ogata, #Kazuyasu Uryu, #Koji Okamura, #Shinichi Kimura, #Tomohiro Ogawa, @Keiichi Ota, @Yasuto Yoneshima, @Naoki Hamada, @Yoichi Nakanishi, @Isamu Okamoto

TRANSLATIONAL LUNG CANCER RESEARCH   10 ( 6 )   2475 - 2486   2021.6

Cytotoxic chemotherapeutic agents and the EGFR-TKI osimertinib induce calreticulin exposure in non-small cell lung cancer Reviewed International journal

#Rie Furukawa, @Hiroyuki Inoue, @Yasuto Yoneshima, #Hirono Tsutsumi, #Eiji Iwama, @Yuki Ikematsu, #Nobuhisa Ando, @Yoshimasa Shiraishi, @Keiichi Ota, @Kentaro Tanaka, @Yoichi Nakanishi, @Isamu Okamoto 1

Lung Cancer   155   144 - 150   2021.5

Clinical utility of pretreatment Glasgow prognostic score in non-small-cell lung cancer patients treated with immune checkpoint inhibitors Reviewed International journal

Shinkichi Takamori, Kazuki Takada, Mototsugu Shimokawa, Taichi Matsubara, Takatoshi Fujishita, Kensaku Ito, Ryo Toyozawa, Masafumi Yamaguchi, Tatsuro Okamoto, @Yasuto Yoneshima, @Kentaro Tanaka, @Isamu Okamoto, Tetsuzo Tagawa, @Masaki Mori

Lung Cancer   152   27 - 33   2021.2

Neural stem cell-specific ITPA deficiency causes neural depolarization and epilepsy Invited Reviewed International journal

@Yuichiro Koga, @Daisuke Tsuchimoto, Yoshinori Hayashi, @Nona Abolhassani, @Yasuto Yoneshima, @Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, @Yusaku Nakabeppu

JCI Insight.   2020.11

Multiclonality and Radiosensitivity of Granulocyte-colony Stimulating Factor-Producing Lung Adenocarcinoma Positive for an Activating EGFR Mutation Invited Reviewed International journal

Hirono Tsutsumi, Yasuto Yoneshima, Keiichi Ota, Kohei Otsubo, Eiji Iwama, Hiroyuki Inoue, Kentaro Tanaka, Yoichi Nakanishi, Isamu Okamoto

Clinical Lung Cancer   21 ( 1 )   e21 - e24   2020.1

Safety and efficacy of PD-1 inhibitors in non–small cell lung cancer patients positive for antinuclear antibodies Reviewed

130   5 - 9   2019.4

Association of nephrotoxicity during platinum-etoposide doublet therapy with UGT1A1 polymorphisms in small cell lung cancer patients Reviewed

Satoshi Anai, Eiji Iwama, Yasuto Yoneshima, Kohei Otsubo, Kentaro Tanaka, Yoichi Nakanishi, Isamu Okamoto

Lung Cancer   126   156 - 161   2018.12

PD-L1 expression in lung adenocarcinoma harboring EGFR mutations or ALK rearrangements Reviewed

Yasuto Yoneshima, Kayo Ijichi, Satoshi Anai, Keiichi Ota, Kohei Otsubo, Eiji Iwama, Kentaro Tanaka, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

Lung Cancer   118   36 - 40   2018.4

Association of preoperative serum CRP with PD-L1 expression in 508 patients with non-small cell lung cancer A comprehensive analysis of systemic inflammatory markers Reviewed

Takaki Akamine, Kazuki Takada, Gouji Toyokawa, Fumihiko Kinoshita, Taichi Matsubara, Yuka Kozuma, Naoki Haratake, Shinkichi Takamori, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Yasuto Yoneshima, Isamu Okamoto, Mototsugu Shimokawa, Yoshinao Oda, Yoichi Nakanishi, Yoshihiko Maehara

Surgical Oncology   27 ( 1 )   88 - 94   2018.3

Two cases of late-onset secondary adrenal insufficiency after discontinuation of nivolumab Reviewed

Kohei Otsubo, K. Nakatomi, R. Furukawa, K. Ashida, Yasuto Yoneshima, Yoichi Nakanishi, Isamu Okamoto

Annals of Oncology   28 ( 12 )   3106 - 3107   2017.12

Marked response to pembrolizumab in a patient with pulmonary pleomorphic carcinoma highly positive for PD-L1 Reviewed

Yuki Ikematsu, Yasuto Yoneshima, Kayo Ijichi, Kentaro Tanaka, Taishi Harada, Yoshinao Oda, Yoichi Nakanishi, Isamu Okamoto

Lung Cancer   112   230 - 231   2017.10

Treatment Rationale and Design for J-AXEL A Randomized Phase 3 Study Comparing Nab-Paclitaxel With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer Reviewed

18 ( 1 )   100 - 103   2017.1

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells Reviewed

Yasuto Yoneshima, Nona Abolhassani, Teruaki Iyama, Sakumi Kunihiko, Naoko Shiomi, Masahiko Mori, Tadahiro Shiomi, Tetsuo Noda, Daisuke Tsuchimoto, Yusaku Nakabeppu

Scientific reports   6   2016.9

Successful treatment with alectinib after crizotinib-induced esophageal ulceration Reviewed

Yasuto Yoneshima, Isamu Okamoto, Tomotsugu Takano, Aimi Enokizu, Eiji Iwama, Taishi Harada, Koichi Takayama, Yoichi Nakanishi

Lung Cancer   88 ( 3 )   349 - 351   2015.6

Infected complex renal cysts during crizotinib therapy in a patient with non-small cell lung cancer positive for ALK rearrangement Reviewed

Yasuto Yoneshima, Isamu Okamoto, Masako Arimura-Omori, Shinichi Kimura, Noriko Hidaka-Fujimoto, Eiji Iwama, Taishi Harada, Koichi Takayama, Yoichi Nakanishi

Investigational New Drugs   33 ( 2 )   510 - 512   2015.4

Carboplatin plus paclitaxel in the successful treatment of advanced inflammatory myofibroblastic tumor Reviewed

Naoki Kubo, Taishi Harada, Satoshi Anai, Kohei Otsubo, Yasuto Yoneshima, Kayo Ijichi, Takaomi Koga, Koichi Takayama, Yoichi Nakanishi

Internal Medicine   51 ( 17 )   2399 - 2401   2012.10

Fosfomycin inhibits NF-κB activation in U-937 and Jurkat cells Reviewed

21 ( 6 )   589 - 592   2003.6

既治療NSCLCに対するnab-パクリタキセルの第3相試験（J-AXEL）：腎機能別サブグループ解析

@米嶋康臣、森田智視、安藤昌彦、中村敦、吉岡弘鎮、近藤征史、三浦理、細見幸生、加藤晃史、久保寿夫、岸本淳司、山本信之、@中西洋一、@岡本勇

第62回日本肺癌学会学術集会  2021.11 

実臨床での免疫チェックポイント阻害薬の免疫関連有害事象予測因子とその対策 Invited

@米嶋康臣

第87回日本呼吸器学会九州支部秋季学術講演会  2021.10 

進行非小細胞肺癌の治療におけるnab-パクリタキセルの役割 Invited

@米嶋康臣

第113回日本肺癌学会関西支部学術集会  2021.2 

Phase III study comparing nab-paclitaxel with docetaxel in patients with previously treated advanced non-small-cell lung cancer International conference

Atsushi Nakamura,@Yasuto Yoneshima, Satoshi Morita, Masahiko Ando, Shunichiro Iwasawa, Hiroshige Yoshioka, Yasuhiro Goto, Masafumi Takeshita, Toshiyuki Harada, Katsuya Hirano, Tetsuya Oguri, Masashi Kondo, Satoru Miura, Yukio Hosomi, Terufumi Kato, Toshio Kubo, @Junji Kishimoto, Nobuyuki Yamamoto, @Yoichi Nakanishi, @Isamu Okamoto

2020 World Conference on Lung Cancer  2021.1 

既治療の進行・再発非小細胞肺癌に対するドセタキセルとnab-パクリタキセルのランダム化比較第III相試験（J-AXEL）

@米嶋康臣、森田智視、安藤昌彦、中村敦、吉岡弘鎮、近藤征史、三浦理、細見幸生、加藤晃史、久保寿夫、@岸本淳司、山本信之、@中西洋一、@岡本勇

第61回日本肺癌学会学術集会  2020.11 

免疫チェックポイント分子リガンドを制御するmiRNAを用いたバイオマーカー開発

Grant number：21K15553  2021 - 2023

日本学術振興会  科学研究費助成事業  若手研究

学術研究支援（奨学寄附金）/特発性肺線維症合併非小細胞肺癌における線維性肺組織および腫瘍組織のTMB測定法を用いたペア解析

2021

Specialist

The Japanese Society of Internal Medicine（JSIM）

Specialist

The Japanese Respiratory Society

Preceptor

The Japanese Respiratory Society