Faculty Profiles - NOSE TAKERU

Information

写真a

NOSE TAKERU

Organization

Faculty of Arts and Science Division for Experimental Natural Science Professor
Promoting Organization for Future Creators （Joint Appointment）
School of Sciences Department of Chemistry（Joint Appointment）
Graduate School of Sciences Department of Chemistry（Joint Appointment）

Contact information

Tel

0928026025

Profile

○Management of KIKAN education As the Vice President of Faculty of Arts and Science, I am in charge of organizing the overall KIKAN education. As a member of the faculty, I manage the discipline subject (chemistry) and develops new subjects. ○Structure-activity relationship studies for receptor proteins and its ligands ○Development of a method for predicting the risk of environmental chemicals (environmental hormones). ○Bioactive peptide sciences, Elastin Peptides

Homepage

https://www.artsci.kyushu-u.ac.jp/~biomolchem/
Laboratory of Biomolecular Chemistry, Kyushu University

External link

Degree

Ph. D

Research History

無し

無し
無し

Research Interests・Research Keywords

Research theme：Peptide Chemistry

Keyword：Peptide Chemistry

Research period： 2024
Research theme：SAR studies for repetitive peptides

Keyword：peptide

Research period： 2013.4
Research theme：Total risk assessment system for endocrine disrupting chemicals

Keyword：endocrine disrupting chemistry, Nuclear receptor, computer modeling

Research period： 1998.4
Research theme：Structural and biological analysis for the activation mechanism of G-protein coupled receptor.

Keyword：G-protein coupled receptor

Research period： 1994.4

Awards

日本ペプチド学会奨励賞

2002.10 日本ペプチド学会「生理活性ペプチドの相互作用におけるπ性相互作用に関する研究」において、特に、アミノ酸側鎖の芳香環が関与するCH/π相互作用の詳細な解析を可能にする、一連の含フッ素フェニルアラニンをユニークな分子ツールとする研究を展開した。これにより、フェニルアラニンを構成アミノ酸とするトロンビン受容体内蔵リガンド、キモトリプシン阻害ジペプチドなどの機能構造要因の解析に成就した。
第15回井上研究奨励賞

1998.12 公益法人井上科学振興財団ヘビ毒トロンビン様酵素とトロンビン受容体に関する構造機能相関研究

Papers

Enhancement of Aggregate Formation Through Aromatic Compound Adsorption in Elastin-like Peptide (FPGVG)5 Analogs. Reviewed International journal

Keitaro Suyama, #Masayuki Murashima, @Iori Maeda, Takeru Nose

Biomacromolecules 24 ( 11 ) 5265 - 5276 2023.11 （ ISSN:1525-7797 eISSN:1526-4602 ）

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Language：English Publishing type：Research paper (scientific journal)

Elastin-like peptides (ELPs) exhibit temperature-dependent reversible self-assembly. Repetitive sequences derived from elastin, such as Val-Pro-Gly-Val-Gly (VPGVG), are essential for the self-assembly of ELPs. Previously, we developed (FPGVG)5 (F5), in which the first valine residue in the VPGVG sequence was replaced with phenylalanine, which showed strong self-aggregation ability. This suggests that interactions through the aromatic amino acid residues of ELPs could play an important role in self-assembly. In this study, we investigated the thermoresponsive behavior of F5 analogs in the presence of aromatic compounds. Turbidimetry, spectroscopy, and fluorescence measurements demonstrated that aromatic compounds interacted with F5 analogs below the transition temperature and enhanced the self-assembly ability of ELPs by stabilizing amyloid-like structures. Furthermore, quantitative high-performance liquid chromatography analyses showed that the F5 analogs could adsorb and remove hydrophobic aromatic compounds from aqueous solutions during aggregate formation. These results suggested that the F5 analogs can be applicable as scavengers of aromatic compounds.

DOI： 10.1021/acs.biomac.3c00779

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Determining the Sequence Dependency of Self-Assembly of Elastin-Like Peptides Using Short Peptide Analogues with Shuffled Repetitive Sequence Reviewed International journal

Daiki Tatsubo, Keitaro Suyama, Naoki Sakamoto, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose

Biochemistry 62 ( 17 ) 2559 - 2570 2023.8 （ ISSN:0006-2960 eISSN:1520-4995 ）

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Language：Japanese Publishing type：Research paper (scientific journal)

Synthetic elastin-like peptides (ELPs) that possess characteristic tropoelastin-derived hydrophobic repetitive sequences, such as (VPGVG)n, exhibit thermoresponsive reversible self-assembly. Although their thermoresponsive properties have been well-studied, the sequence-dependent and structural requirements for self-assembly remain ambiguous. In particular, it is still unclear whether the amino acid sequences derived from tropoelastin are necessary for self-assembly. In this study, 11 sequence-shuffled ELP analogues based on (FPGVG)5, which is a previously developed short ELP (sELP), were designed to elucidate the sequence-dependent and structural requirements for their self-assembly. Among them, eight shuffled peptides exhibited self-assembling properties, whereas the other three peptides were difficult to dissolve in water. Structural analyses revealed that the structural characteristics of the three insoluble peptides were different from those of their thermoresponsive analogues. Furthermore, the secondary structures of the peptide analogues possessing the self-assembly abilities were different from each other. These results suggest that the potential for self-assembly and water solubility of sELPs depend on the primary structure in each repeated unit. Moreover, several shuffled analogues exhibited more potent self-assembling properties than the original (FPGVG)5, indicating that shorter ELPs can be obtained using their novel motifs as repetitive units. We also observed that the presence of Pro-Gly sequence in the repeating units was advantageous in terms of peptide solubility. Although further analysis will be necessary to elucidate the molecular mechanism underlying the self-assembly of these sELPs, this study provides insights into the relationship between the amino acid sequence and the self-assembling ability of the peptides for developing new sELPs for various applications.

DOI： 10.1021/acs.biochem.3c00146

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Development of truncated elastin-like peptide analogues with improved temperature-response and self-assembling properties Reviewed International journal

Shogo Sumiyoshi, Keitaro Suyama, Naoki Tanaka, Takumi Andoh, Akihiko Nagata, Keisuke Tomohara, Suguru Taniguchi, Iori Maeda, Takeru Nose

Scientific Reports 12 ( 1 ) 19414 - 19414 2022.11 （ ISSN:2045-2322 eISSN:2045-2322 ）

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Language：Others Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Functional peptides, which are composed of proteinogenic natural amino acids, are expected to be used as biomaterials with minimal environmental impact. Synthesizing a functional peptide with a shorter amino acid sequence while retaining its function is a easy and economical strategy. Furthermore, shortening functional peptides helps to elucidate the mechanism of their functional core region. Truncated elastin-like peptides (ELPs) are peptides consisting of repetitive sequences, derived from the elastic protein tropoelastin, that show the thermosensitive formation of coacervates. In this study, to obtain shortened ELP analogues, we synthesized several (Phe-Pro-Gly-Val-Gly)n (FPGVG)n analogues with one or two amino acid residues deleted from each repeat sequence, such as the peptide analogues consisting of FPGV and/or FPG sequences. Among the novel truncated ELP analogues, the 16-mer (FPGV)4 exhibited a stronger coacervation ability than the 25-mer (FPGVG)5. These results indicated that the coacervation ability of truncated ELPs was affected by the amino acid sequence and not by the peptide chain length. Based on this finding, we prepared Cd2+-binding sequence-conjugated ELP analogue, AADAAC-(FPGV)4, and found that it could capture Cd2+. These results indicated that the 16-mer (FPGV)4 only composed of proteinogenic amino acids could be a new biomaterial with low environmental impact.

DOI： 10.1038/s41598-022-23940-0

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Other Link： https://www.nature.com/articles/s41598-022-23940-0
Metal ion scavenging activity of elastin-like peptide analogues containing a cadmium ion binding sequence Reviewed International journal

#Shogo Sumiyoshi, Keitaro Suyama, #Daiki Tatsubo, #Naoki Tanaka, Keisuke Tomohara, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

SCIENTIFIC REPORTS 12 ( 1 ) 1861 - 1861 2022.2 （ ISSN:2045-2322 ）

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal)

The development of simple and safe methods for recovering environmental pollutants, such as heavy metals, is needed for sustainable environmental management. Short elastin-like peptide (ELP) analogues conjugated with metal chelating agents are considered to be useful as metal sequestering agents as they are readily produced, environment friendly, and the metal binding domain can be selected based on any target metal of interest. Due to the temperature dependent self-assembly of ELP, the peptide-based sequestering agents can be transformed from the solution state into the particles that chelate metal ions, which can then be collected as precipitates. In this study, we developed a peptide-based sequestering agent, AADAAC-(FPGVG)4, by introducing the metal-binding sequence AADAAC on the N-terminus of a short ELP, (FPGVG)4. In turbidity measurements, AADAAC-(FPGVG)4 revealed strong self-assembling ability in the presence of metal ions such as Cd2+ and Zn2+. The results from colorimetric analysis indicated that AADAAC-(FPGVG)4 could capture Cd2+ and Zn2+. Furthermore, AADAAC-(FPGVG)4 that bound to metal ions could be readily recycled by treatment with acidic solution without compromising its metal binding affinity. The present study indicates that the fusion of the metal-binding sequence and ELP is a useful and powerful strategy to develop cost-effective heavy metal scavenging agents with low environmental impacts.

DOI： 10.1038/s41598-022-05695-w

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Simple Regulation of the Self-Assembling Ability by Multimerization of Elastin-Derived Peptide (FPGVG)n Using Nitrilotriacetic Acid as a Building Block Reviewed International journal

Suyama Keitaro, #Mawatari Mika, Tatsubo, Daiki, @Maeda Iori, Nose Takeru

ACS Omega 6 ( 8 ) 5705 - 5716 2021.2

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Authorship：Last author,　Corresponding author Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1021/acsomega.0c06140
Evaluation of the Influence of Halogenation on the Binding of Bisphenol A to the Estrogen-Related Receptor γ Reviewed

33 ( 4 ) 889 - 902 2020.4

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Halogenation of organic compounds is one the most important transformations in chemical synthesis and is used for the production of various industrial products. A variety of halogenated bisphenol analogs have recently been developed and are used as alternatives to bisphenol A (BPA), which is a raw material of polycarbonate that has adverse effects in animals. However, limited information is available on the potential toxicity of the halogenated BPA analogs. In the present study, to assess the latent toxicity of halogenated BPA analogs, we evaluated the binding and transcriptional activities of halogenated BPA analogs to the estrogen-related receptor γ(ERRÎ³), a nuclear receptor that contributes to the growth of nerves and sexual glands. Fluorinated BPA analogs demonstrated strong ERRγbinding potency, and inverse antagonistic activity, similar to BPA. X-ray crystallography and fragment molecular orbital (FMO) calculation revealed that a fluorine-substituted BPA analog could interact with several amino acid residues of ERRÎ³-LBD, strengthening the binding affinity of the analogs. The ERRγbinding affinity and transcriptional activity of the halogenated BPAs decreased with the increase in the size and number of halogen atom(s). The IC₅₀ values, determined by the competitive binding assay, correlated well with the binding energy obtained from the docking calculation, suggesting that the docking calculation could correctly estimate the ERRγbinding potency of the BPA analogs. These results confirmed that ERRγhas a ligand binding pocket that fits very well to BPA. Furthermore, this study showed that the binding affinity of the BPA analogs can be predicted by the docking calculation, indicating the importance of the calculation method in the risk assessment of halogenated compounds.

DOI： 10.1021/acs.chemrestox.9b00379
Enhancement of self-aggregation properties of linear elastin-derived short peptides by simple cyclization strong self-aggregation properties of cyclo[FPGVG]_n, consisting only of natural amino acids Reviewed International journal

Keitaro Suyama, #Daiki Tatsubo, @Wataru Iwasaki, @Masaya Miyazaki, @Yuhei Kiyota, Ichiro Takahashi, @Iori Maeda, Takeru Nose

Biomacromolecules 19 ( 8 ) 3201 - 3211 2018.6

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DOI： 10.1021/acs.biomac.8b00353
Stepwise Mechanism of Temperature-Dependent Coacervation of the Elastin-like Peptide Analogue Dimer, (C(WPGVG)₃)₂ Reviewed International journal

#Daiki Tatsubo, Keitaro Suyama, Masaya Miyazaki, @Iori Maeda, Takeru Nose

Biochemistry 57 ( 10 ) 1582 - 1590 2018.2

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DOI： 10.1021/acs.biochem.7b01144
Dimerization effects on coacervation property of an elastin-derived synthetic peptide (FPGVG)5 Reviewed International journal

Keitaro Suyama, Suguru Taniguchi, Daiki Tatsubo, Iori Maeda, Takeru Nose

Journal of Peptide Science 22 236 - 243 2016.3

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DOI： 10.1002/psc.2876
Exploration of endocrine-disrupting chemicals on estrogen receptor α by the agonist/antagonist differential-docking screening (AADS) method: 4-(1-Adamantyl)phenol as a potent endocrine disruptor candidate Reviewed International journal

2009.11

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Ammonium carboxylates in the ammonia-Ugi reaction: one-pot synthesis of α,α-disubstituted amino acid derivatives including unnatural dipeptides

Tomohara, K; Kusaba, S; Masui, M; Uchida, T; Nambu, H; Nose, T

ORGANIC & BIOMOLECULAR CHEMISTRY 22 ( 34 ) 6999 - 7005 2024.8 （ ISSN:1477-0520 eISSN:1477-0539 ）

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Language：English Publisher：Organic and Biomolecular Chemistry

Despite the remarkable developments of the Ugi reaction and its variants, the use of ammonia in the Ugi reaction has long been recognized as impractical and unsuccessful. Indeed, the ammonia-Ugi reaction often requires harsh reaction conditions, such as heating and microwave irradiation, and competes with the Passerini reaction, thereby resulting in low yields. This study describes a robust and practical ammonia-Ugi reaction protocol. Using originally prepared ammonium carboxylates in trifluoroethanol, the ammonia-Ugi reaction proceeded at room temperature in high yields and showed a broad substrate scope, thus synthesizing a variety of α,α-disubstituted amino acid derivatives, including unnatural dipeptides. The reaction required no condensing agents and proceeded without racemization of the chiral stereocenter of α-amino acids. Furthermore, using this protocol, we quickly synthesized a novel dipeptide, d-Leu-Aic-NH-CH2Ph(p-F), which exhibited a potent inhibitory activity against α-chymotrypsin with a Ki value of 0.091 μM.

DOI： 10.1039/d4ob00924j

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薬史を題材とした学部生向けの英語ライティング教材の開発 Reviewed

友原啓介, #田中尚輝, #吉田耕平, @長谷川直人, @足立伊佐雄, 野瀬健

薬学史雑誌 58 ( 2 ) 100 - 109 2023.12

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DOI： https://doi.org/10.34531/jjhp.58.2_100
Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach Reviewed International journal

Keisuke Tomohara, @Juthamart Maneenet, #Nao Ohashi, Takeru Nose, @Rintaro Fujii, @Min Jo Kim, @Sijia Sun, @Suresh Awale

Biological and Pharmaceutical Bulletin 46 ( 10 ) 1412 - 1420 2023.10

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DOI： https://doi.org/10.1248/bpb.b23-00224
Development of the efficient preparation method for thermoresponsive elastin‐like peptides using liquid‐phase synthesis combined with fragment condensation strategy Reviewed International journal

#Kohei Yoshida, Keitaro Suyama, #Shin Matsushita, @Iori Maeda, Takeru Nose

Journal of Peptide Science 29 ( 12 ) e3528 2023.6 （ ISSN:1075-2617 eISSN:1099-1387 ）

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Language：Others Publishing type：Research paper (scientific journal) Publisher：Wiley

DOI： 10.1002/psc.3528

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ポストコロナにおける大学生の生活・健康・心理の状態

梶谷康介, 岸本裕歩, 土本利架子, 長沼祥太郎, 鄭漢模, 野瀬健, 田中真理, 丸山徹, 丸野俊一

大学のメンタルヘルス 5 56 - 60 2023.3 （ ISSN:2433-2615 ）

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Language：Japanese Publisher：(NPO)全国大学メンタルヘルス学会

新型コロナウイルス感染症(COVID-19)の世界的流行は、多くの人々の生活・健康に悪影響を及ぼしており、これは大学生も例外ではない。そこで我々は2020年6月1日から6月9日にかけて、九州大学の学部生と大学院生を対象に生活・健康に関するアンケートを実施した。その結果、1.居住形態は自宅(実家)が全体の5割弱であり、特に学部1年生においては7割近くの学生が自宅であった、2.生活リズムについては概ね守られている、3.大半の学生は概ね適切な睡眠時間を確保できていた、4.全体の4割以上の学生が体調不良を訴えた、5.教員とのコミュニケーションが十分で無い学生が6割近くいる一方、友人とのコミュニケーションについては6割以上取れている、6.悩みについては勉学・将来・経済的問題が上位であった、7.悩みの相談先は大学入学前の友人、家族が多い、8.全体の4割の学生が気分の落ち込みを経験している、9.全体の4割近い学生が孤独感・孤立感を感じている、10.全体の4割近い学生が大学生活に「満足している」あるいは「まあまあ満足してる」一方、2割の学生が「やや不満」「不満」と感じている(学部1年生は4割が「やや不満」「不満」と回答)。今回のアンケート結果から、学生への支援を行うにあたり、様々な側面からのサポートが必要であることが明らかになった。コロナ禍の学生への支援はいまだに何が正解か分からないが、学生からのニーズを吸い上げ、支援のあり方を柔軟に変化させ、大学側も「ウィズコロナ」に適応することが重要である。(著者抄録)
Development of temperature-responsive short-chain peptide analogues based on elastin-like peptide FPGVG Reviewed International journal

Keitaro Suyama, #Shogo Sumiyoshi, #Naoki Tanaka, #Takumi Ando, #Akihiro Nagata, Keisuke Tomohara, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

Peptide Science 2022 141 - 142 2023.3

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Language：English Publishing type：Research paper (international conference proceedings)
Development of temperature-responsive peptides by EDTA-mediated multimerization of short (FPGVG)n chains Reviewed International journal

#Naoki, Tanaka, Keitaro Suyama, Keisuke Tomohara, @Iori Maeda, Takeru Nose

Peptide Science 2022 83 - 84 2023.3

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Branched short elastin-like peptides with temperature responsiveness obtained by EDTA-mediated multimerization Reviewed

Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, Iori Maeda, Takeru Nose

JOURNAL OF PEPTIDE SCIENCE 29 ( 2 ) e3449 2023.2 （ ISSN:1075-2617 eISSN:1099-1387 ）

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Elastin-like peptides (ELPs) exhibit a reversible phase transition, known as coacervation, triggered by temperature changes. This property makes them useful as stimuli-responsive molecular materials for various applications. Among ELPs, short peptide chain lengths have some advantages over long peptide chain lengths because short ELPs can be easily obtained by chemical synthesis, allowing the use of various amino acids, including D-type and unnatural amino acids, at any position in the sequence. Moreover, the incorporated amino acids readily affect the temperature-responsive behavior of ELPs. However, to be utilized in various applications, it is necessary to develop short ELPs and to investigate their temperature-responsive properties. To obtain further insights into the temperature-responsive behavior of the short ELPs, we investigated branched short ELP analogs composed of (FPGVG)(n) chains (n = 1 or 2, abbreviated as F1 and F2, respectively). We synthesized multimers composed of four F1 chains or two to four F2 chains using ethylenediaminetetraacetic acid (EDTA) as a central component of multimerization. Our results show that the multimers obtained exhibited coacervation in aqueous solutions whereas linear F1 or F2 did not. Furthermore, the structural features of the obtained multimers were the same as those of linear (FPGVG)(4). In this study, we demonstrated that molecules capable of coacervation can be obtained by multimerization of F1 or F2. The temperature-responsive molecules obtained using short ELPs make it possible to use them as easy-to-synthesize peptide tags to confer temperature responsiveness to various molecules, which will aid the development of temperature-responsive biomaterials with a wide variety of functions.

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High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways. Reviewed International journal

Keitaro Suyama, #Hitoshi Kesamaru, #Takashi Okubo, #Kazumi Kasatani, Keisuke Tomohara, Ayami Matsushima, Takeru Nose

Heliyon 9 ( 1 ) e13003 2023.1 （ ISSN:24058440 eISSN:2405-8440 ）

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Halogenated flame retardants comprising bisphenol A (BPA) derivatives, such as tetrabromobisphenol A (TBBPA), have been studied their adverse effects on human health. However, despite the fact that these halogenated BPAs are easily degraded in the environment, the risks to living organisms due to these degraded products have mostly been overlooked. To evaluate the potential toxicity of degraded TBBPAs and related compounds, we examined the cytotoxicity of halogenated bisphenol A derivatives possessing one to four halogen atoms in vitro. The results indicated that the degraded TBBPA derivatives exhibited strong cytotoxicity against HeLa cells than TBBPA. Interestingly, the di-halogenated BPA derivatives possessing two halogen atoms exhibited the strongest cytotoxicity among tested compounds. In addition, a lactate dehydrogenase release assay, fluorescence spectroscopy and flow cytometry results indicated that dibromo-BPA and diiodo-BPA induced both apoptotic and necrotic cell death by damaging the cell membranes of HeLa cells. Moreover, Escherichia coli growth was inhibited in the presence of dehalogenated TBBPA and related compounds. These findings suggest that halogenated BPA derivatives that leak from various flame-retardant-containing products require strict monitoring, as not only TBBPA but also its degraded products in environment can exert adverse effects to human health.

DOI： 10.1016/j.heliyon.2023.e13003

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Synthesis of natural product hybrids by the Ugi reaction in complex media containing plant extracts Reviewed International journal

Keisuke Tomohara, #Nao Ohashi, Tatsuya Uchida, Takeru Nose.

Scientific Reports 12 ( 1 ) 15568 - 15568 2022.9 （ ISSN:2045-2322 ）

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Plant extracts are rich in a wide variety of molecules with diverse biological activities. Chemical engineering of plant extracts has provided a straightforward and simultaneous synthetic route for artificial molecules derived from plant products. This study achieved the synthesis of 13 natural product-like molecules by the Ugi multicomponent reaction using plant extracts as substrates. In particular, the engineering of a mixture of plant extracts demonstrated a unique synthetic route to a series of natural product hybrids, whereby otherwise unencountered naturally occurring molecules of different origins were chemically hybridized in complex media. Even though these reactions took place in complex media containing plant extracts, the well-designed process achieved a good conversion efficiency (~ 60%), chemoselectivity, and reproducibility. Additionally, some of the Ugi adducts exhibited promising inhibitory activity toward protease.

DOI： 10.1038/s41598-022-19579-6

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Branched short elastin‐like peptides with temperature responsiveness obtained by EDTA‐mediated multimerization Reviewed International journal

e3449 2022.8

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Language：English Publishing type：Research paper (scientific journal)

Elastin-like peptides (ELPs) exhibit a reversible phase transition, known as coacerva- tion, triggered by temperature changes. This property makes them useful as stimuli- responsive molecular materials for various applications. Among ELPs, short peptide chain lengths have some advantages over long peptide chain lengths because short ELPs can be easily obtained by chemical synthesis, allowing the use of various amino acids, including D-type and unnatural amino acids, at any position in the sequence. Moreover, the incorporated amino acids readily affect the temperature-responsive behavior of ELPs. However, to be utilized in various applications, it is necessary to develop short ELPs and to investigate their temperature-responsive properties. To obtain further insights into the temperature-responsive behavior of the short ELPs, we investigated branched short ELP analogs composed of (FPGVG)n chains (n = 1 or 2, abbreviated as F1 and F2, respectively). We synthesized multimers composed of four F1 chains or two to four F2 chains using ethylenediaminetetraacetic acid (EDTA) as a central component of multimerization. Our results show that the multimers obtained exhibited coacervation in aqueous solutions whereas linear F1 or F2 did not. Furthermore, the structural features of the obtained multimers were the same as those of linear (FPGVG)4. In this study, we demonstrated that molecules capable of coacervation can be obtained by multimerization of F1 or F2. The temperature- responsive molecules obtained using short ELPs make it possible to use them as easy-to-synthesize peptide tags to confer temperature responsiveness to various molecules, which will aid the development of temperature-responsive biomaterials with a wide variety of functions.

DOI： DOI: 10.1002/psc.3449
Flexible customization of the self-assembling abilities of short elastin-like peptide Fn analogs by substituting N-terminal amino acids Reviewed International journal

Keitaro Suyama, #Marin Shimizu, @Iori Maeda, Takeru Nose

BIOPOLYMERS 113 ( 10 ) e23521 2022.7 （ ISSN:0006-3525 eISSN:1097-0282 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：WILEY

Elastin-like peptides (ELPs) are thermoresponsive biopolymers inspired by the characteristic repetitive sequences of natural elastin. As ELPs exhibit temperature-dependent reversible self-assembly, they are expected to be biocompatible thermoresponsive materials for drug delivery carriers. One of the most widely studied ELPs in this field is the repetitive pentapeptide, (VPGXG)(n). We previously reported that phenylalanine-containing ELP (Fn) analogs, in which the former Val residue of the repetitive sequence (VPGVG)(n) is replaced by Phe, show coacervation with a short chain length (n = 5). Owing to their short sequences, Fn analogs are easily modified in amino acid sequences via simple chemical synthesis, and are useful for investigating the relationship between peptide sequences and temperature responsiveness. In this study, we developed Fn analogs by replacing Phe residue(s) with other amino acids or introducing another amino acid at the N-terminus. The temperature responsiveness of the Fn analogs changed drastically with the substitution of a single Phe residue, suggesting that aromatic amino acids play an important role in their self-assembly. In addition, the self-assembling ability of Fn was enhanced by increasing the bulkiness of the N-terminal amino acids. Therefore, the N-terminal residue was considered to be important for hydrophobicity-induced intermolecular interactions between the peptides during coacervation.

DOI： 10.1002/bip.23521

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Development of temperature-responsive short-chain peptide analogues based on elastin-like peptide FPGVG Reviewed International journal

Keitaro Suyama, #Shogo Sumiyoshi, #Naoki Tanaka, #Takumi Ando, #Akihiko Nagata, Keisuke Tomohara, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

Peptide Science 2021 141 - 142 2022.3

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Development of Temperature-responsive Peptides by EDTA-mediated Multimerization of Short (FPGVG)n Chains Reviewed International journal

#Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, @Iori Maeda, Takeru Nose

Peptide Science 2021 83 - 84 2022.3

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Language：English Publishing type：Research paper (international conference proceedings)
Comparison of Changes in Student Survey Results during the Corona Pandemic

NAGANUMA Shotaro, JEONG Hanmo, NOSE Takeru

8 137 - 153 2022.2 （ ISSN:21892571 eISSN:2189258X ）

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Language：Japanese Publisher：Faculty of Arts and Science, Kyushu University

This report compared the common items in the two questionnaires on online classes conducted at Kyushu University in 2020 and 2021. The following five findings were obtained: 1) there was an overall increase in student life satisfaction between 2020 and 2021; 2) when comparing the ease of learning in online classes with face-to-face classes, there was a slight increase in the total percent of "better", "slightly better", and "almost the same" for online classes; 3) the troubles with online classes decreased from 2020 to 2021; 4) a comparison of attitudes and impressions of online classes showed that faculty members and students seemed to be adapting to online classes, whereas negative trends were also observed seemingly due to "online classes habituation"; 5) with regard to points for improvement of online classes, there was a decrease in the number of opinions pointing out problems in all question items. These results may reflect the university's sincere efforts to implement online classes over the past year. On the other hand, certain issues still persist, so we pointed out the importance of continuing to address these issues in the future if we welcome online classes even after corona pandemic.

DOI： 10.15017/4773095

CiNii Research
Direct evidence of edge-to-face CH/pi interaction for PAR-1 thrombin receptor activation Invited Reviewed International journal

Asai Daisuke, Inoue, Naoko, Sugiyama Makiko, Fujita Tsugumi, Matsuyama Yutaka, Liu, Xiaohui, Matsushima Ayami, Nose Takeru, Costa, Tommaso, Shimohigashi Yasuyuki

BIOORGANIC & MEDICINAL CHEMISTRY 51 2021.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.bmc.2021.116498
Bisphenol A derivatives act as novel coactivator-binding inhibitors for estrogen receptor β Reviewed International journal

297 ( 5 ) 101173 - 101173 2021.10

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Bisphenol A and its derivatives are recognized as endocrine disruptors based on their complex effects on estrogen receptor (ER) signaling. While the effects of bisphenol derivatives on ERα have been thoroughly evaluated, how these chemicals affect ERβ signaling is less well understood. Herein, we sought to identify novel ERβ ligands using a radioligand competitive binding assay to screen a chemical library of bisphenol derivatives. Many of the compounds identified showed intriguing dual activities as both ERα agonists and ERβ antagonists. Docking simulations of these compounds and ERβ suggested that they bound not only to the canonical binding site of ERβ but also to the coactivator binding site located on the surface of the receptor, suggesting that they act as coactivator-binding inhibitors (CBIs). Receptor-ligand binding experiments using WT and mutated ERβ support the presence of a second ligand-interaction position at the coactivator-binding site in ERβ, and direct binding experiments of ERβ and a coactivator peptide confirmed that these compounds act as CBIs. Our study is the first to propose that bisphenol derivatives act as CBIs, presenting critical insight for the future development of ER signaling-based drugs and their potential to function as endocrine disruptors.

DOI： https://doi.org/10.1016/j.jbc.2021.101173
九州大学におけるティーチング・アシスタント制度改革 : 1 年間の記録 Reviewed

鄭　漢模、長沼祥太郎、野瀬健、丸野俊一

基幹教育紀要 7 189 - 212 2021.3

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Repository Public URL： http://hdl.handle.net/2324/4363544
Role of Phe residues in elastin-like peptide (FPGVG)₅ on self-assembly properties Reviewed International journal

Keitaro Suyama, #Marin Shimizu, @Iori Maeda, Takeru Nose

Peptide Science 2020 59 - 60 2021.3

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Fractionation of water-soluble elastin from pig aorta by coacervation method Reviewed International journal

@Iori Maeda, @Suguru Taniguchi,@Yumi Moriuchi, @Naruhiko Sawa,@Asako Inoue, @Tomoyuki Usa, @Noriko Watanabe, Keitaro Suyama, Takeru Nose

Peptide Science 2020 65 - 66 2021.3

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Development of self-aggregating elastin-like peptide analogs with a metal-binding sequence Reviewed International journal

#Shogo Sumiyoshi, Keitaro Suyama, Takeru Nose

Peptide Science 2020 67 - 68 2021.3

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Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and NURR1 Reviewed International journal

#Koki Tagawa, Keitaro Suyama, Hitoshi Kesamaru, #Takahiro Masuya, Takeru Nose, Ayami Matsushima

Peptide Science 2020 123 - 124 2021.3

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Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding Reviewed International journal

16 ( 2 ) e0246583 2021.2

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We reported that bisphenol AF (BPAF) works as an agonist for estrogen receptor (ER) ERα
but as an antagonist for ERβ. Similar results were observed for bisphenol E analogs (BPEX)
such as BPE-F, BPE-Cl, and BPE-Br, each consisting of a series of a tri-halogenated
methyl group CX3 in the central alkyl moiety. It was demonstrated that the electrostatic halogen
bond based on the dispersion force of halogen atoms is a major driving force in the
activities of bifunctional ERα-agonist and ERβ-antagonist. Since the chlorine atoms present
in bisphenol C (BPC) exist in a π-π conjugated system due to the presence of an adjacent
C = C double bond, we intended to prove that BPC is also a bifunctional ERα-agonist and
ERβ-antagonist exhibiting greatly enhanced agonist/antagonist activities. BPC was evaluated
for its ability to activate ERα and ERβ in the luciferase reporter gene assay using HeLa
cells. With high receptor-binding ability to both ERs, BPC was found to be fully active for
ERα but inactive for ERβ. BPC’s definite antagonist activity in ERβ was revealed by its inhibitory
activity against 17β-estradiol. Thus, BPC is a bifunctional ERα-agonist and ERβ-antagonist. These agonist/antagonist activities were discovered to be extremely high among series of halogen-containing bisphenol compounds. This comparative structure-activity study revealed that the ascending order of ERα-agonist and ERβ-antagonist activities was BPE-F << BPE-Cl ≲ BPAF < BPE-Br << BPC. The highly intensified receptor interaction of BPC is attributable to the presence of an n-π-π-n conjugation system mediated through the >C = CCl₂ double bond.

DOI： https://doi.org/ 10.1371/journal.pone.0246583
Mechanistic Insights into a DMSO-Perturbing Inhibitory Assay of Hyaluronidase Reviewed International journal

Keisuke Tomohara, #Nao Ohashi, Takeru Nose

Biochemistry 59 ( 40 ) 3879 - 3888 2020.9

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DOI： https://doi.org/10.1021/acs.biochem.0c00594
Concentration Dependent Coacervation Property of Nonlinear Elastin-derived Peptide (FPGVG)n Analogs Reviewed International journal

Keitaro Suyama, #Mika Mawatari, #Daiki Tatsubo, @Iori Maeda, Takeru Nose

Peptide Science 2019 29 - 30 2020.3

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初年次学生向け総合的実験科目の大学間比較 Reviewed

小林良彦、野瀬健

基幹教育紀要 6 83 - 98 2020.3

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日本の大学におけるTAの実態について : 九州大学の事例を手掛かりに Reviewed

李麗花、野瀬健、丸野俊一

基幹教育紀要 6 33 - 49 2020.3

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Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
Stability of Phe-containing Elastin-like Peptides against Proteases in Digestive Organs Reviewed International journal

@Iori Maeda, @Miki Kawakami, @Suguru Taniguchi, Keitaro Suyama, Takeru Nose

Peptide Science 2019 161 - 162 2020.3

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Development of Liposome Like Nanostructures Composed of Short Amphiphilic Elastin-Like Peptides Reviewed International journal

#Naoki Sakamoto, #Daiki Tatsubo, #Keiji Sato, Keisuke Tomohara, Keitaro Suyama, @Iori Maeda, Takeru Nose.

Peptide Science 2019 113 - 114 2020.3

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Bisphenol AF Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities Reviewed

28 ( 3 ) 2020.2

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17β-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ERα and ERβ. We recently observed that CF₃-containing bisphenol AF (BPAF) works as an agonist for ERα but as an antagonist for ERβ. Similar results were also observed for the CCl₃-containing bisphenol designated as HPTE. Both BPAF and HPTE are comprised of a tri-halogenated methyl group in the central alkyl moiety of their bisphenol structures, which strongly suggests that halogens contribute directly to the agonist/antagonist dual biological functions. We conducted this study to investigate the structure-activity relationships by assessing together newly synthesized CF₃- and CBr₃-containing bisphenol E analogs (BPE-X). We first tested bisphenols for their receptor binding ability and then for their transcriptional activities. Halogen-containing bisphenols were found to be fully active for ERα, but almost completely inactive for ERβ. When we examined these bisphenols for their inhibitory activities for E2 in ERβ, we observed that they worked as distinct antagonists. The ascending order of agonist/antagonist dual biological functions was BPE-F < BPE-Cl (HPTE) ≤ BPAF < BPE-Br, demonstrating that the electrostatic halogen bonding effect is a major driving force of the bifunctional ERα agonist and ERβ antagonist activities of BPAF.

DOI： 10.1016/j.bmc.2019.115274
Early identification of promiscuous attributes of aldose reductase inhibitors using a DMSO-perturbation assay Reviewed

Keisuke Tomohara, Naoto Hasegawa, Isao Adachi, Yoshikazu Horino, Takeru Nose

Bioorganic and Medicinal Chemistry Letters 30 ( 2 ) 2020.1

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DOI： 10.1016/j.bmcl.2019.126815
Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors Reviewed

Xiaohui Liu, Hiroki Sakai, Mitsuhiro Nishigori, Keitaro Suyama, Tasuku Nawaji, Shin Ikeda, Makoto Nishigouchi, Hiroyuki Okada, Ayami Matsushima, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi

Toxicology and Applied Pharmacology 377 2019.8

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DOI： 10.1016/j.taap.2019.114610
DMSO-Perturbing Assay for Identifying Promiscuous Enzyme Inhibitors Reviewed International journal

Keisuke Tomohara, Isao Adachi, Yoshikazu Horino, Hitoshi Kesamaru, Hitoshi Abe, Keitaro Suyama, Takeru Nose

ACS Medicinal Chemistry Letters 10 ( 6 ) 923 - 928 2019.5

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DOI： 10.1021/acsmedchemlett.9b00093
Importance of Receptor Conformations in Docking Calculation-Based Risk Assessment for Endocrine Disruptors against Estrogen Receptor α Reviewed

4 ( 4 ) 6620 - 6629 2019.4

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Employment of appropriate receptor conformations as templates is essential for appropriate identification of the latent receptor binding ability of chemicals using in silico docking calculations. In this study, we performed docking calculations using a number of agonist- and antagonist-bound conformations of 83 estrogen receptor (ER) α-ligand-binding domains as templates to clarify the type of receptor conformations required for reasonable identification of endocrine disruptors. Our results showed that 17β-estradiol and diethylstilbestrol (ERα agonists) bound preferentially to the agonist conformations, whereas 4-hydroxytamoxifen and raloxifene (ERα antagonists) bound selectively to the antagonist conformations. We also observed that bisphenol A analogues, which are partial agonists, bound more moderately and preferentially to the agonist conformations as compared with the antagonist conformations. Additionally, the docking calculations were able to estimate biological agonist or antagonist activity of chemicals based on the receptor conformation selectivity. Furthermore, structural analyses of the ligand-binding domains and docking calculation utilizing C-terminal-truncated receptors indicated that the C-terminal regions of these domains were capable of discriminating agonists from nonagonists. These results suggest that both agonist- and antagonist-binding conformations of receptors are necessary to predict the binding affinity and biological activity of chemicals for docking calculation-based risk assessment. Furthermore, this in silico method can be beneficial for drug discovery because it is useful for rapid searching of ligands for receptors and preventing the side effects caused by unfavorable receptor binding.

DOI： 10.1021/acsomega.9b00050
次世代型大学教育開発センターが開催したFD の九州大学における位置づけ Reviewed

小林良彦、中世古　貴彦、野瀬　健

基幹教育紀要 5 99 - 108 2019.3

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Characterization of alpha-Chymotrypsin Inhibitors by DMSO-Perturbing Assay Reviewed International journal

Peptide Science 2018 107 - 108 2019.3

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Development of self-assembling short elastin-derived peptide analogs: linear and nonlinear (FPGVG)_n analogs Reviewed International journal

Keitaro Suyama, #Daiki Tatsubo, @Suguru Taniguchi, @Iori Maeda, and Takeru Nose

Peptide Science 2018 117 - 117 2019.3

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Structure and Function of the Elastin-like Short Peptide Analogs with Shuffled Sequences Based on (FPGVG)₅ Reviewed International journal

#Daiki Tatsubo, Keitaro Suyama, @Iori Maeda, and Takeru Nose

Peptide Science 2018 65 - 65 2019.3

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基幹教育セミナーにおける学生の意識の変容 : 4 学期制導入に伴う授業内容変更とセミナーの意義に焦点を当てて Reviewed

鎌滝晋礼, 小島健太郎, 飯嶋裕治, 内田竜也, 大河内豊, 大久保文哉, 斎藤新悟, 猿渡悦子, セビリア・アントン, 田中真理, 野瀬健, 川島啓二, 安永和央, 木村政伸

基幹教育紀要 5 57 - 74 2019.3

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Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
Effects of Salts and pH on Coacervation of Short Elastin-Like Peptide (FPGVG)₅ Reviewed International journal

#Daiki Tatsubo, #Misako Kodama, #Keiji Sato, Keitaro Suyama, @Iori Maeda, and Takeru Nose

Peptide Science 2017 62 - 63 2018.3

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基幹教育における理系ディシプリン教養系科目の受講傾向リベラルサイエンス教育開発のための状況調査 Reviewed

小林良彦、野瀬　健

基幹教育紀要 4 67 - 76 2018.3

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Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
Angiotensin I Converting Enzyme-inhibiting Peptides Purified from Elastase-degraded Elastin Prepared from Pig Aorta Reviewed International journal

@Iori Maeda, @Shohei Kai, @Suguru Taniguchi, @Asako Inoue, @Hujun Li, #Hitoshi Kesamaru, Takeru Nose

Current Enzyme Inhibition 14 67 - 74 2018.3

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2174/1573408013666170912113121
Multifunctional biological activities of water extract of housefly larvae (Musca domestica) Reviewed International journal

@Hujun Li, @Asako Inoue, @Suguru Taniguchi, @Tomohiko Yukutake, Keitaro Suyama, Takeru Nose, @Iori Maeda

PharmaNutrition 5 ( 4 ) 119 - 126 2017.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.phanu.2017.09.001
Analysis of structural requirement for coacervation property of elastin model peptide dimers Reviewed International journal

Daiki Tatsubo, Keitaro Suyama, Takeru Nose

Peptide Science 2016 13 - 14 2017.3

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Coacervation Property and Structural Analysis of Cyclic Analogs of Elastin-derived Peptide (FPGVG)_n Reviewed International journal

Keitaro Suyama, #Hitoshi Kesamaru, #Daiki Tatsubo, Takeru Nose

Peptide Science 2016 101 - 102 2017.3

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分野横断的新実験科目「実験を通して学ぶアミノ酸の科学」の開発 Reviewed

巣山慶太郎, Takeru Nose

基幹教育紀要 3 47 - 52 2017.3

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Language：Japanese Publishing type：Research paper (bulletin of university, research institution)
Investigation of water-soluble elastin as a multifunctional cosmetic material: Moisturizing and whitening effects Reviewed International journal

Asako Inoue, Tomohiro Hikima, Suguru Taniguchi, Takeru Nose, Iori Maeda

JOURNAL OF COSMETIC SCIENCE 68 1 - 13 2017.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/psc.2837
Role of individual disulfide bridges in the conformation and activity of spinoxin (α-KTx6.13), a potassium channel toxin from Heterometrus spinifer scorpion venom Reviewed International journal

山口容子, Steve Peigneur, 劉　俊驛, Shiho Uemura, Takeru Nose, Selvanayagam Nirthanan, Ponnampalam Gopalakrishnakone, Jan Tytgat, 佐藤一紀

122 31 - 38 2016.11

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DOI： 10.1016/j.toxicon.2016.09.013
Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning Reviewed International journal

Biochemistry 55 ( 21 ) 2927 - 2935 2016.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1021/acs.biochem.6b00139
Coacervation Properties and Structural Analysis of Aminobenzoyl-labeled Fluorescent Elastin-derived Peptides Reviewed International journal

Keitaro Suyama, Hitoshi Kesamaru, Daiki Tatsubo, Takeru Nose

Peptide Science 2015 293 - 294 2016.3

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新入学生の意識調査に基づく基幹教育セミナーの学習成果の検討 Reviewed

小島健太郎, TATSUYA UCHIDA, 飯嶋裕治, 緒方広明, 川島啓二, 斎藤新悟, 佐合紀親, 猿渡悦子, 田中岳, 田中真理, Takeru Nose

基幹教育紀要 2 73 - 85 2016.3

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Fluorescence Analysis Using a Molecular Probe 1,8-ANS for Elucidation of the Molecular Mechanisms Underlying Coacervation of a Tryptophan-containing Elastin derived Dimeric Peptide Reviewed International journal

Daiki Tatsubo, Keitaro Suyama, Takeru Nose

Peptide Science 2015 95 - 96 2016.3

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Development of short and highly potent self-assembling elastin-derived pentapeptide repeats containing aromatic amino acid residues Reviewed International journal

Suguru Taniguchi, Noriko Watanabe, Takeru Nose, Iori Maeda

JOURNAL OF PEPTIDE SCIENCE 22 ( 1 ) 36 - 42 2016.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1002/psc.2837
Design of Phenylalanine-Containing Elastin-Derived Peptides Exhibiting Highly Potent Self-Assembling Capability Reviewed International journal

Iori Maeda, Suguru Taniguchi, Noriko Watanabe, Asako Inoue, Yuko Yamazaki, Takeru Nose

Protein & Peptide Letters 22 ( 10 ) 939 - 939 2015.8

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DOI： 10.2174/092986652210150821170703
Structure-function relationships of spinoxin, a peptide neurotoxin from scorpion venom Reviewed International journal

Peptide Science 2014 55 - 56 2015.3

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基幹教育セミナーの実施体制について Reviewed

野瀬健, 飯嶋裕治, 小島健太郎, 佐合紀親, 斎藤伸吾,　猿渡悦子,　田中岳, 内田竜也

基幹教育紀要 1 63 - 69 2015.3

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Language：Japanese Publishing type：Research paper (bulletin of university, research institution)

DOI： 10.15017/1495422
基幹教育課題協学科目 Reviewed

Kenji Furuya, Yutaka Okochi, Atsushi Shimada, 田中岳, Takeru Nose, Shinji Yamagata

基幹教育紀要 1 63 - 69 2015.3

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Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.15017/1495422
Identification of an Elastin-derived Peptide Degrade in Human Blood After Oral Ingestion of Elastin Reviewed International journal

Iori Maeda, Suguru Taniguchi, Takeru Nose

Peptide Science 2014 305 - 306 2015.3

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Coacervation property and structural analysis of synthetic dimer peptides of aromatic amino acid containing elastin-derived peptides Reviewed International journal

Keitaro Suyama, Daiki Tatsubo, Suguru Taniguchi, Hitoshi Kesamaru, Iori Maeda, Takeru Nose

Peptide Science 2014 323 - 324 2015.3

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Coacervation Property and Secondary Structure of Synthetic Dimer Peptides of Elastin-Derived Pentapeptide Repeats Reviewed International journal

Keitaro Suyama, Suguru Taniguchi, Iori Maeda, Daiki Tatsubo, Takeru Nose

Peptide Science 2013 277 - 278 2014.3

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Coacervation Properties of Short Elastin-Derived Pentapeptide Analogues Containing Aromatic Amino Acids Reviewed International journal

Suguru Taniguchi, Noriko Watanabe, Takao Hattori, Taishi Inatomi, Asako Inoue, Yuko Yamasaki, Takeru Nose, Iori Maeda

Peptide Science 2013 433 - 434 2014.3

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Preparing of Phenylalanine Containing Elastin-Derived Pentapeptide Based Biomaterials Reviewed International journal

Asako Inoue, Suguru Taniguchi, Yuko Yamasaki, Masakazu Furuta, Takeru Nose, Iori Maeda

Peptide Science 2013 431 - 432 2014.3

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Structure-Activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs Reviewed International journal

Yumi Kuramitsu, Hirokazu Nishimura, Ryo Nakamura, Keitaro Suyama, Ayami Matsushima, Takeru Nose, Yasuyuki Shimohigashi

Peptide Science 2013 319 - 320 2014.3

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Comparison between Coacervation Property and Secondary Structure of Synthetic Peptides, Ile-containing Elastin-derived Pentapeptide Repeats Reviewed International journal

Iori Maeda, Suguru Taniguchi, Junko Ebina, Noriko Watanabe, Takao Hattori, Takeru Nose

Protein and Peptide Letters 20 ( 8 ) 905 - 910 2013.8

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DOI： 10.2174/0929866511320080007
Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities Reviewed International journal

Nishio K, Nishimura H, Suyama K, Matsushima A, Nose T, Shimohigashi

Peptide Science 2012 2013.3

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Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing Reviewed International journal

Y. Matsuyama, X. Liu, H. Nishimura, A. Matsushima, T. Nose, Y. Shimohigashi

Peptide Science 2012 2013.3

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Coacervation properties of hydrophobic elastin-derived pentapeptide analogues Reviewed International journal

Maniwa Y., Inoue A., Watanabe N., Ogino Y., Yamasaki Y., Nose T., Maeda I.

Peptide Science 2012 2013.3

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High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs Reviewed International journal

Y. Kuramitsu, H. Nishimura, R. Nakamura, K. Suyama, A. Matsushima, T. Nose, Y. Shimohigashi

Peptide Science 2012 2013.3

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Highly Potent Binding and Inverse Agonist Activity of Bisphenol A Derivatives for Retinoid-related Orphan Nuclear Receptor RORg Reviewed International journal

Mitsuhiro Nishigori, Takeru Nose, Yasuyuki Shimohigashi

Toxicol. Lett., 212 ( 2 ) 205 - 211 2012.5

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Structural Characteristics of Thr-Gly Dipeptide Repeat in the Drosophila Clock Protein PERIOD Reviewed International journal

Matsuo A, Nishimura H, Nakamura M, Koga K, Sumiyoshi M, Matsushima A, Nose T, Shimohigashi M, and Shimohigashi Y

Peptide Science 2011 2012.3

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Functional Analysis of a Histidine Residue Essential for Receptor Activation of Delta Opioid Receptor Reviewed International journal

Abe Y, Matsuo T, Nishimura H, Li J, Nose T, Costa T, and Shimohigashi Y

Peptide Science 2011 2012.3

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Receptor-binding Characteristics of Tritium-labeled Pure Antagonist Peptide for Hyperalgesic Nociceptin ORL1 Receptor Reviewed International journal

Inamine S, Nishimura H, Li J, Matsushima A, Nose T, Costa T, and Shimohigashi Y

Peptide Science 2011 2012.3

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Structural Analysis of Delta Opioid Receptor Dimer by Bivalent Deltorphin II Analogs Reviewed International journal

Ito N, Nishimura H, Matsushima A, Nose T, Costa T, and Shimohigashi Y

Peptide Science 2011 2012.3

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Effects of the Halogenation of Phe-phenyl Group of Two Consecutive Residues in endomorphin-2 on the Interaction with the μ-opioid receptors Reviewed International journal

2012.3

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The Effects of Halogenation of Phe-phenyl Group of Two Consecutive Phe Residues Present in Neuropeptide Substance P on its Specific Receptor Interaction Reviewed International journal

Nakamura R, Nishimura H, Suyama K, Nose T, and Shimohigashi Y

Peptide Science 2011 2012.3

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Structural Essentials of Hyperalgesic Nociceptin ORL1 Receptor for Ligand Binding and Receptor Activation Reviewed International journal

Nishimura H, Li J, Isozaki K, Abe Y, Inamine S, Matsushima A, Nose T, Costa T, and Shimohigashi Y

Peptide Science 2011 2012.3

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Protease-immobilized Microreactor for Rapid and Site-specific Affinity Tag Cleavage Reviewed International journal

Asanomi Y, Koga Y, Miyazaki M, Nose T, Kodama H, and Maeda H.

Peptide Science 2011 2012.3

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Fine Spatial Assembly for Construction of the Phenol Binding Pocket to Capture Bisphenol A in the Human Nuclear Receptor ERRγ Reviewed International journal

151 ( 4 ) 2012.1

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Various lines of evidence have shown that bisphenol A (BPA) acts as an endocrine disruptor that affects various hormones even at merely physiological levels. We demonstrated recently that BPA binds strongly to human nuclear receptor estrogen-related receptor γ (ERRγ), one of 48 nuclear receptors. Based on X-ray crystal analysis of the ERRγ ligand-binding domain (LBD)/BPA complex, we demonstrated that ERRγ receptor residues, Glu275 and Arg316, function as the intrinsic-binding site of the phenol–hydroxyl group of BPA. If these phenol–hydroxyl↔Glu275 and Arg316 hydrogen bonds anchor the A-benzene ring of BPA, the benzene–phenyl group of BPA would be in a pocket constructed by specific amino acid side chain structures. In the present study, by evaluating the Ala-replaced mutant receptors, we identified such a ligand-binding pocket. Leu268, Leu271, Leu309 and Tyr326, in addition to the previously reported participants Glu275 and Arg316, were found to make a receptacle pocket for the A-ring, whereas Ile279, Ile310 and Val313 were found to assist or structurally support these residues. The results revealed that each amino acid residue is an essential structural element for the strong binding of BPA to ERRγ.

DOI： 10.1093/jb/mvs008

Other Link： http://jb.oxfordjournals.org/content/151/4/403
Structural Requirements Essential for Elastin Coacervation: Favorable Spatial Arrangements of Valine Ridges on the Three-dimensional Structure of Elastin-derived Polypeptide (VPGVG)n Reviewed International journal

Maeda I., Fukumoto Y., Nose T., Shimohigashi Y., Nezu T., Terada Y., Kodama H., Kaibara K., and Okamoto K.

J. Pept. Sci. 17 ( 11 ) 2011.6

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DOI： 10.1002/psc.1394

Other Link： http://onlinelibrary.wiley.com/doi/10.1002/psc.1394/full
A Trp Residue of Opioid Receptor TM5 is Present at the Cell Membrane Interface as a Molecular Anchor for Full Activation Reviewed International journal

Nishimura H., Li J., Inokuchi N., Koikawa S., Nose T., Matsushima A., Costa T., and Shimohigashi Y.

Peptide Science 2010 2011.3

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Exploration of the Binding Site of ORL1 Nociceptin Receptor Antagonist Reviewed International journal

Inamine S, Li J, Nishimura H, Matsushima A, Nose T, Costa T, and Shimohigashi Y

Peptide Science 2010 2011.3

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The functional role of Trp present at the cell membrane interface in the opioid receptor activation Reviewed International journal

Nishimura H., Li J., Inokuchi N., Koikawa S., Matsushima A., Nose T., Costa T., Shimohigashi Y.

Peptide Science 2009 2010.3

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The agonist/antagonist differential-docking screening (AADS) method for exploration of the estrogen receptor-binding chemicals Reviewed International journal

Nose T., Tokunaga T., Shimohigashi Y.

Peptide Science 2009 2010.3

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Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis Reviewed International journal

Li J., Isozaki K., Matsushima A., Nose T., Costa T., Shimohigashi Y.

Peptide Science 2009 2010.3

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Spare Interactions of Highly Potent [Arg14,Lys15]nociceptin for Cooperative Induction of ORL1 Receptor Activation Reviewed International journal

Isozaki K., Li J., Okada K., Nishimura H., Matsushima A., Nose T., Costa T., Shimohigashi Y.

Bioorg. Med. Chem., 17 ( 23 ) 2009.12

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Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation. Reviewed International journal

Nishimura H., Li J., Isozaki K., Okada K., Matsushima A., Nose T., Costa T., Shimohigashi Y.

Bioorg. Med. Chem., 2009.8

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Essential Amino Acid Residues in the ORL1 Receptor Transmembrane Domains for Receptor Activation Reviewed International journal

Li J., Isozaki K., Nose T., Costa T., Shimohigashi Y.

Peptide Science 2008 2009.1

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The Effects of Arg→Trp and Lys →Trp Substitutions for Arg-Lys14-15 Residues in a Superagonist [Arg-Lys14-15]-Nociceptin on the ORL1 Receptor Binding and Activation Reviewed International journal

2009.1

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Molecular Mechanism of alpha-Helix Peptide That Inhibits Intermolecular Interaction of Prion Protein N-Terminal Tetrarepeaat Domain Reviewed International journal

Koga K., Nose T., Horiuchi Y., Shimohigashi Y.

Peptide Science 2008 2009.1

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Histidines as Structurally Essential Residue for the Delta Opioid Receptor Activation Reviewed International journal

Matsuo T., Abe Y., Li J., Isozaki K., Nose T., Shimohigashi Y.

Peptide Science 2008 2009.1

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Radar Chart Deviation Analysis of Prion Protein Amino Acid Composition Defines Characteristics Structural Abnomalities of the N-Terminal Octapeptide Tandem Repeat Reviewed International journal

Yokotani S., Nose T., Horiuchi Y., Matsushima A., and Shimohigashi Y.

Protein Pept. Lett., 2008.10

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Designed Modification of Partial Agonist of ORL1 Nociceptin Receptor for Conversion into Highly Potent Antagonist Reviewed International journal

Li J., Isozaki K., Okada K., Matsushima A., Nose T., Costa T., and Shimohigashi Y.

Bioorg. Med. Chem., 2008.10

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Synergistic Effect of Basic Residues at Positions 14-15 of Nociceptin on Binding Affinity and Receptor Activation Reviewed International journal

Okada K., Isozaki K., Li J., Matsushima A., Nose T., Costa T., and Shimohigashi Y.

Bioorg. Med. Chem., 2008.9

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A docking modelling rationally predicts strong binding of bisphenol A to estrogen-related receptor γ Reviewed International journal

2008.3

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Structural Profiles for Coaservation of Elastin-derived Polypeptides International journal

I. Maeda, Y. Fukumoto, T. Nose, Y. Shimohigashi, T. Nezu, Y. Terada, H. Kodama, K. Kaibara, K. Okamoto

Peptide Science 2007 2008.3

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Optimization of the N-terminal Group of Ac-RYYRIL-NH2 as ORL1 Receptor Antagonist International journal

J. Li, K. Isozaki, A. Matsushima, T. Nose, T. Costa, Y. Shimohigashi

Peptide Science 2007 2008.3

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Structural Analysis of Excitatory Neuropeptides TEP-1 and TEP-2 Isolated from the Prosobraanch Gastopod Thais clavigera International journal

Y. Horiuchi, T. Nose, Y. Abe, Y. Shimohigashi, F. Morishita

Peptide Science 2007 2008.3

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The Molecular Mechanism of ORL1 Nociceptin Receptor in Activation: Residual Essential in the Sixth Transmembrane Domain International journal

K. Isozaki, J. Li, T. Nose, T. Costa, Y. Shimohigashi

Peptide Science 2007 2008.3

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Differential Receptor Recognition by Dmt-Containing Enlephalin Dimers Cross-Linked by Phenylenediamines International journal

N. Inokuchi, K. Isozaki, Y. Tsuda, Y. Okada, S. Osada, T. Nose, T. Costa, Y. Shimohigashi

Peptide Science 2007 2008.3

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The Conformation Change-Sensing Antibodies for Retinoid-Related Orphan Receptor Family International journal

M. Nishigori, T. Nose, X. Liu, T. Tokunaga, Y. Shimohigashi

Peptide Science 2007 2008.3

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Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist Reviewed International journal

Jinglan Li, Kaname Isozaki, Kazushi Okada, Ayami Matsushima, Takeru Nose, Tommaso Costa and Yasuyuki Shimohigashia

Bioorganic and Medicinal Chemistry 2007.11

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Differential receptor binding characteristics of consecutive phenylalanines in μ-opioid specific peptide ligand endomorphin-2 Reviewed

15 ( 11 ) 3883 - 3888 2007.6

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Endogenous opioid peptides consist of a conserved amino acid residue of Phe³ and Phe⁴, although their binding modes for opioid receptors have not been elucidated in detail. Endomorphin-2, which is highly selective and specific for the μ opioid receptor, possesses two Phe residues at the consecutive positions 3 and 4. In order to clarify the role of Phe³ and Phe⁴ in binding to the μ receptor, we synthesized a series of analogs in which Phe³ and Phe⁴ were replaced by various amino acids. It was found that the aromaticity of the Phe-β-phenyl groups of Phe³ and Phe⁴ is a principal determinant of how strongly it binds to the receptor, although better molecular hydrophobicity reinforces the activity. The receptor binding subsites of Phe³ and Phe⁴ of endomorphin-2 were found to exhibit different structural requirements. The results suggest that [Trp³]endomorphin-2 (native endomorphin-1) and endomorphin-2 bind to different receptor subclasses.

DOI： 10.1016/j.bmc.2007.03.009
Residual Roles of Hydrophobic Amino Acids in the Fifth Transmembrane Domain of ORL1 Receptor in Its Activation International journal

K. Isozaki, K. Okada, S. Koikawa, T. Nose, T. Costa, and Y. Shimohigashi

Peptide Science 2006 2006.11

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Conformation Change of α-Helix Peptide for Sensing of Deactivation of Nuclear Receptor: Immunoassay Using Polyclonal Antibody Specific for the C-terminal α-Helix 12 of Estrogen-related Receptor γ (ERRγ) International journal

2006.11

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Synthesis of Pure Antagonist of ORL1 Nociceptin Receptor International journal

J. Li, K. Isozaki, K. Okada, T. Nose, T. Costa, and Y. Shimohigashi

Peptide Science 2006 2006.11

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Conformation Sensing Assay Using Polyclonal Antibody Specific for the C-terminal α-helix of Glucocorticoid Receptor and Progesterone Receptor International journal

2006.3

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Enkephalin Dimers Cross-linked by Diaminobenzene for Homodimeric Opioid Receptors Expressed in COS-7 Cells International journal

J. Funama, K. Isozaki, T. Nose, T. Coosta, and Y. Shimohigashi

Peptide Science 2005 2006.3

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Continuous Activation of the δ-opioid Receptor by Affinity Labeling International journal

2006.3

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α-Helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change in nuclear receptors International journal

2006.3

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Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina Reviewed International journal

A. Matsushima, S. Yokotani, X.H. Lui, K. Sumida, T. Honda, S. Sato, A. Kaneki, Y. Takeda, Y. Chuman, M. Ozaki, D. Asai, T. Nose, H. Onoue, Y. Ito, Y. Tominaga, Y. Shimohigashi, and M. Shimohigashi

Lett. Peptide Sci. 10 ( 5-6 ) 419 - 430 2004.5

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DOI： 10.1007/BF02442573
cDNA Cloning of the Housefly Pigment-Dispersing Factor (PDF) Precursor Protein and Its Peptide Comparison among the Insect Circadian Neuropeptides Reviewed International journal

A. Matsushima, S. Sato, Y. Chuman, Y. Takeda, S. Yokotani, T. Nose, Y. Tomioka, M. Shimohigashi, and Y. Shimohigashi

J. Peptide Sci. 10 ( 2 ) 82 - 91 2004.2

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DOI： 10.1002/psc.511
Aggregation feature of fluorine-substituted benzene rings and intermolecular C-H center dot center dot center dot F interaction: Crystal structure analyses of mono- and trifluoro-L-phenylalanines Reviewed International journal

Y. In, S. Kishima, K. Minoura, T. Nose, Y. Shimohigashi, and T. Ishida

Chem. Pharm. Bull., 51 ( 11 ) 1258 - 1263 2003.11

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DOI： 10.1248/cpb.51.1258
Site-directed affinity-labeling of delta opioid receptors by SNpys-containing enkephalin and dynorphin analogues Reviewed International journal

K. Isozaki, H. Fukahori, T. Honda, N. Shirasu, K. Okada, T. Nose, K. Sakaguchi, and Y. Shimohigashi

Lett. Peptide Sci., 10 ( 5-6 ) 511 - 522 2003.5

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DOI： 10.1007/BF02442583
Structural Requirements of Nociceptin Antagonist Ac-RYYRIK-NH2 for Receptor Binding Reviewed International journal

M. Kawano, K. Okada, T. Honda, T. Nose, K. Sakaguchi, T. Costa, and Y. Shimohigashi

J. Peptide Sci., 8 ( 10 ) 561 - 569 2002.10

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DOI： 10.1002/psc.415
Characterization, Primary Structure and Molecular Evolution of Anticoagulant Protein from Agkistrodon actus Venom Reviewed International journal

A. Tani, T. Ogawa, T. Nose, N. N. Nikandrov, M. Deshimaru, T. Chijiwa, C.-C. Chang, Y. Fukumaki, and M. Ohno

Toxicon 40 ( 6 ) 803 - 813 2002.6

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DOI： 10.1016/S0041-0101(01)00289-6
Exploration of the Role of Phenylalanine in the Thrombin Receptor Tethered-Ligand by Substitution with a Series of Trifluorophenylalanines Reviewed International journal

A. Matsushima, T. Fujita, K. Okada, N. Shirasu, T. Nose, and Y. Shimohigashi

Bull. Chem. Soc. Jpn. 73 ( 11 ) 2531 - 2538 2000.11

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DOI： 10.1246/bcsj.73.2531
The Role of Deltorphin II Phenylalanine Residue in Binding to the δ Opioid Receptor Reviewed International journal

73 ( 11 ) 2549 - 2552 2000.11

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DOI： 10.1246/bcsj.73.2549
Head-to-Tail Polymerization of Coagulin, a Clottable Protein of the Horseshoe Crab Reviewed International journal

H. Kawasaki, T. Nose, T. Muta, S. Iwanaga, Y. Shimohigashi, and S. Kawabata

J. Biol. Chem. 275 ( 45 ) 35297 - 35301 2000.11

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DOI： 10.1074/jbc.M006856200
Highly potent Nociceptin Analog Containing the Arg-Lys Triple Repeat Reviewed International journal

K. Okada, T. Sujaku, Y. Chuman, R. Nakashima, T. Nose, T. Costa, Y. Yamada, M. Yokoyama, A. Nagahisa, and Y. Shimohigashi

Biochem. Biophys. Res. Commun. 278 ( 2 ) 493 - 498 2000.11

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DOI： 10.1006/bbrc.2000.3822
Synthesis of a Complete Set of L-difluorophenylalanines, L-(F-2)Phe, as Molecular Explorers for the CH/π Interaction between Peptide Ligand and Receptor Reviewed International journal

41 ( 6 ) 923 - 927 2000.6

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DOI： 10.1016/S0040-4039(99)02191-7
Edge-to-face CH/π Interaction between Ligand Phe-phenyl and Receptor Aromatic Group in the Thrombin Receptor Activation Reviewed International journal

128 ( 2 ) 225 - 232 2000.2

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Structural Essentials of Xenoestrogen Dialkyl Phthalates to Bind to the Estrogen Receptors Reviewed International journal

D. Asai, Y. Tahara, M. Nakai, Y. Yakabe, M. Takatsuki, T. Nose, T. Shinmyozu, and Y. Shimohigashi

Toxicology Lett. 118 ( 1-2 ) 1 - 8 2000.1

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DOI： 10.1016/S0378-4274(00)00253-8
Effects of Substitution of Hydrophobic Amino Acid by Tryptophan on Receptor Binding and Biological Activity of Neuropeptide Nociceptin Reviewed International journal

K. Okada, T. Sujaku, R. Nakashima, T. Nose, Y. Yamada, M. Yokoyama, A. Nagahisa, and Y. Shimohigashi

Bull. Chem. Soc. Jpn. 72 ( 8 ) 1899 - 1904 1999.8

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DOI： 10.1246/bcsj.72.1899
In Vivo and In Vitro Evidences of Blood-Brain Barrier Transport of a Novel Cationic Arginine-Vasopressin Fragment 4-9 Analogue Reviewed International journal

S. Tanabe, Y. Shimohigashi, Y. Nakayama, T. Makino, T. Fujita, T. Nose, G. Tsujimoto, T. Yokokura, M. Naito, T. Tsuruo, and T. Terasaki

J. Pharmacol. Exp. Ther., 290 ( 2 ) 561 - 568 1999.8

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Design of Serine Protease Inhibitors with Conformation Restricted by Amino Acid Side Chain-Side Chain CH/π Interaction Reviewed International journal

51 ( 1 ) 9 - 17 1999.6

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DOI： 10.1002/(SICI)1097-0282(1999)51:1<9::AID-BIP3>3.0.CO;2-5
A novel Molecular Design of Thrombin Receptor Antagonist Reviewed International journal

T. Fujita, M. Nakajima, Y. Inoue, T. Nose, and Y. Shimohigashi

Bioorg. Med. Chem. Lett. 9 ( 10 ) 1351 - 1356 1999.5

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DOI： 10.1016/S0960-894X(99)00202-4
Design and Syntheses of para-Fluorophenylalanine Amide Derivatives as Thrombin Receptor Antagonist Reviewed International journal

T. Fujita, T. Nose, M. Nakajima, Y. Inoue, T. Costa, and Y. Shimohigashi

J. Biochem. 126 ( 1 ) 174 - 179 1999.1

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Exploration of Universal Cysteines in the Binding Site of Three Opioid Receptor Subtypes by Disulfide-Bonding Affinity Labeling with Chemically Activated Thiol-containing Dynorphin A Analogs Reviewed International journal

N. Shirasu, T. Kuromizu, H. Nakao, Y. Chuman, T. Nose, T. Costa, and Y. Shimohigashi

J. Biochem., 126 ( 1 ) 254 - 259 1999.1

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The Role of Arginine in Thrombin Receptor Tethered-Ligand Peptide in Intramolecular Receptor Binding and Self-activation Reviewed International journal

Nose, T., Satoh, Y., Fujita, T., Ohno, M., Nakajima, M., Inoue, Y., Ogino, Y., Costa, T., and Shimohigashi, Y

Bull. Chem. Soc. Jpn., 71 ( 7 ) 1661 - 1665 1998.7

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DOI： 10.1246/bcsj.71.1661
X-ray Crystal Structure of a Dipeptide-Chymotrypsin Complex in an Inhibitory Interaction Reviewed International journal

A. Kashima, Y. Inoue, S. Sugio, I. Maeda, T. Nose, and Y. Shimohigashi

Eur. J. Biochem. 255 ( 1 ) 12 - 23 1998.7

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DOI： 10.1046/j.1432-1327.1998.2550012.x
Interaction Mode of the Phe-phenyl Group of Thrombin Receptor Tethered-ligand SFLLRNP in Receptor Activation Reviewed International journal

T. Nose, T. Fujita, M. Nakajima, Y. Inoue, T. Costa, and Y. Shimohigashi

J. Biochem. 124 ( 2 ) 354 - 358 1998.2

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Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide Reviewed

Yasuyuki Shimohigashi, Ryo Hatano, Tsugumi Fujita, Rie Nakashima, Takeru Nose, Tetsujo Sujaku, Aki Saigo, Katsuhiro Shinjo, Atsushi Nagahisa

Journal of Biological Chemistry 271 ( 39 ) 23642 - 23645 1996.10

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DOI： 10.1074/jbc.271.39.23642
Chymotrypsin inhibition induced by side chain-side chain intramolecular CH/π interaction in D-Thr-L-Phe benzylamide Reviewed

119 ( 5 ) 870 - 877 1996.5

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The dipeptide benzyl amide H-D-Thr-Phe-NH-CH₂-C₆H₅ was found to inhibit chymotrypsin strongly (K(i) = 4.5 x 10^-6 M) in a competitive manner. When a series of phenyl amides H-D-Thr-Phe-NH-(CH₂)(n)-C₆H₅ (n = 0-4) were tested, inhibitory potency peaked at n = 1 (benzyl amide). Incorporation of a methyl group into the benzyl methylene resulted in formation of stereoisomers, H-D-Thr-Phe-NH-(R or S)-CH(CH₃)-C₆H₅, with considerably different inhibitory potencies. The R-isomer was as active as the benzyl amide, while the S-isomer was about 30-fold less active than the benzyl amide. Furthermore, when a fluorine atom was introduced into the para-position of the amide-benzyl group, the resulting H-D-Thr-Phe-NH-CH₂-C₆H₄(p-F) showed considerably enhanced inhibitory activity (about 5-fold, K(i) = 9.1 x 10^-7 M). In conformational analysis by 400 mHz ¹H-NMR, all dipeptides having D-Thr-Phe backbone structure showed large upheld shifts of D-Thr-βOH (shifts in ppm, 0.09-0.17), D-Thr-βCH (0.23-0.32), and D-Thr-γCH₃ (0.38-0.53), indicating the presence of shielding effects from the benzene ring. In addition, NOE enhancements between the D-Thr-γCH₃ and Phe-phenyl groups were evidenced by measurements of two-dimensional NOESY spectra and NOE difference spectra. These observations demonstrated the spatial proximity of these side chains, which is due to side chain-side chain CH/π interaction. All these results support the idea that the amide-benzyl group binds at the chymotrypsin S₁ site, while the hydrophobic core with CH/π interaction binds at the S₂ or S₁' site.
Chymotrypsin inhibitory conformation induced by amino acid side chain-side chain intramolecular CH/π interaction Reviewed

( 20 ) 2479 - 2485 1996.1

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Dipeptide amides H-D-Leu-Phe-NH-R have been found to assume a conformation induced by the CH/π interaction and to inhibit chymotrypsin strongly. A series of benzyl amide derivatives H-D-Leu-Phe-NH-[CH₂]_n-C₆H₅ (n = 0-4) have been assayed for chymotrypsin. They inhibit the enzyme in a competitive manner and the highest inhibition is achieved by the amide of n = 1 (K_i = 3.6 × 10^-6 M). The activity enhancement is dependent upon the length of methylene chain, not upon the increase in molecular hydrophobicity, indicating the presence of an optimal distance between dipeptide backbone and C-terminal phenyl group for chymotrypsin inhibition. The C-terminal phenyl group has been found to interact with chymotrypsin stereospecifically. The R-isomer of H-D-Leu-Phe-NH-CH(CH₃)-C₆H₅ is as active as the benzyl amide, while the S-isomer is about twenty-fold less active. When the fluorine atom is introduced at a para-position of the C-terminal phenyl group, the resulting dipeptide H-D-Leu-Phe-NH-CH₂-C₆H₄F-p exhibits about six-times increased inhibitory activity (K_i = 6.1 × 107 M; this dipeptide is one of the most potent chymotrypsin inhibitors to date). ¹H NMR conformational analyses of these dipeptide amide derivatives show the CH/π interaction between D-Leu-isobutyl and Phe-phenyl as a key structural element for chymotrypsin inhibition. These structural examinations strongly suggest that in the inhibitory conformation the C-terminal phenyl group fits the chymotrypsin S₁ site, while the hydrophobic core constructed by D-Leu-Phe CH/π interaction fits the chymotrypsin S₂ or S₁′ site.

DOI： 10.1039/P19960002479
Reversible affinity labeling of opioid receptors via disulfide bonding Discriminative labeling of μ and δ subtypes by chemically activated thiol-containing enkephalin analogs Reviewed

120 ( 2 ) 459 - 465 1996.1

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The 3-nitro-2-pyridinesulfenyl (Npys) group bound to a mercapto group is a highly activated electrophilic reagent, which only reacts with a free mercapto group to form a disulfide bond via the thiol-disulfide exchange reaction. We incorporated the Npys group into enkephalin analogs to affinity label μ and δ opioid receptors. When rat brain membranes were incubated with [D-Ala²,Leu(CH₂SNpys)⁵] enkephalin, and assayed for the inhibition of binding of DAGO and DSLET enkephalin analogs to opioid receptors, the number of receptors decreased sharply, depending upon the concentration of this SNpys-containing enkephalin. It was found that this enkephalin analog occupies μ receptors highly specifically (EC₅₀, = 51 nM) and almost 100 times more selectively than δ receptors. In contrast, [D-Ala²,Leu⁵] enkephalyl-Cys(Npys)⁶ attached covalently to δ receptors (EC₅₀ = 34 nM) about 150 times more selectively than to μ receptors. Although N-ethylmaleimide also inhibited the binding of DAGO and DSLET, four to six orders of magnitude higher concentrations were required as compared to SNpys-containing enkephalins. When enkephalin-bound rat membranes were treated with dithiothreitol, the loss of receptors was reversed, depending upon the concentration of and incubation time with dithiothreitol. The recovery was much faster (about 1,000 times) for δ receptors than for μ. receptors. The present results indicated that both μ and δ receptors in rat brain consist of a free mercapto group near the enkephalin binding site and that SNpys-containing enkephalins can label these mercapto groups discriminatively. The disulfide bond between [D-Ala²,Leu⁵]enkephalyl-Cys⁶ and δ receptors appears to be exposed, while that between [D-Ala²,Leu(CH₂SNpys)⁵] enkephalin and μ receptors is shielded.

DOI： 10.1093/oxfordjournals.jbchem.a021433
Different roles of two consecutive leucine residues in a receptor-tethered ligand peptide (SFLLRNP) in thrombin receptor activation Reviewed

T. Nose, Y. Shimohigashi, M. Okazaki, Y. Satoh, T. Costa, N. Shimizu, Y. Ogino, M. Ohno

Bulletin of the Chemical Society of Japan 68 ( 9 ) 2695 - 2698 1995.9

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DOI： 10.1246/bcsj.68.2695
Human thrombin receptors are insensitive to thrombin-like snake venom enzymes Reviewed International journal

Y. Shimohigashi, Takeru Nose, M. Ohno, Y. Ogino, T. Costa

Biochemistry and Molecular Biology International 35 ( 2 ) 415 - 421 1995.2

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Language：English Publishing type：Research paper (scientific journal)
Differential roles of two consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation Reviewed

Yasuyuki Shimohigashi, Takeru Nose, Mika Okazaki, Yusuke Satoh, Motonori Ohno, Tommaso Costa, Naokata Shimizu, Yoshio Ogino

Biochemical and Biophysical Research Communications 203 ( 1 ) 366 - 372 1994.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1006/bbrc.1994.2191
Structural essentials of Ser-1 in tethered peptide ligand of human thrombin receptor for phosphoinositide hydrolysis Reviewed

K. Sakaguchi, H. Kodama, Y. Ogino, T. Costa, Takeru Nose, Y. Shimohigashi

Bulletin of the Chemical Society of Japan 67 ( 6 ) 1659 - 1663 1994.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1246/bcsj.67.1659
Role of Src homology 3 domains in assembly and activation of the phagocyte NADPH oxidase Reviewed

Hideki Sumimoto, Yohko Kage, Hiroyuki Nunoi, Hiroyuki Sasaki, Takeru Nose, Yasuyuki Fukumaki, Motonori Ohno, Shigeki Minakami, Koichiro Takeshige

Proceedings of the National Academy of Sciences of the United States of America 91 ( 12 ) 5345 - 5349 1994.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1073/pnas.91.12.5345
Hairpin loop and second kringle domain are essential sites for heparin binding and biological activity of hepatocyte growth factor Reviewed

Kensaku Mizuno, Hayao Inoue, Michio Hagiya, Shin Shimizu, Takeru Nose, Yasuyuki Shimohigashi, Toshikazu Nakamura

Journal of Biological Chemistry 269 ( 2 ) 1131 - 1136 1994.1

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Language：English Publishing type：Research paper (scientific journal)
Purification and characterization of a coagulant enzyme, okinaxobin II, from Trimeresurs okinavensis (himehabu snake) venom which releases fibrinopeptides A and B Reviewed

Takeru Nose, Yasuyuki Shimohigashi, Shosaku Hattori, Hiroshi Kihara, Motonori Ohno

Toxicon 32 ( 12 ) 1509 - 1520 1994.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/0041-0101(94)90309-3
Purification, sequencing and characterization of single amino acid-substituted phospholipase A₂ isozymes from Trimeresurus Gramineus (green habu snake) venom Reviewed

Toyoka Fukagawa, Takeru Nose, Yasuyuki Shimohigashi, Tomohisa Ogawa, Naoko Oda, Kin ichi Nakashima, Chun Chang Chang, Motonori Ohno

Toxicon 31 ( 8 ) 957 - 967 1993.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/0041-0101(93)90255-H
Chymotrypsin inhibitory conformation of dipeptides constructed by side chain–side chain hydrophobic interactions Reviewed

Hiroshi Sakamoto, Yasuyuki Shimohigashi, Iori Maeda, Takeru Nose, Kin‐ichi ‐i Nakashima, Ichiro Nakamura, Tomoshisa Ogawa, Motonori Ohno, Keiichi Kawano

6 ( 2 ) 95 - 100 1993.6

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Language：English Publishing type：Research paper (scientific journal)

A complete series of configurationally isomers (L‐L, L‐D, D‐L AND D‐D) of a dipeptide Leu‐Phe benzyl ester have been synthesized and assayed for chymotrypsin. In the conformational analysis by 400 MMz ¹H NMR, the L‐D and D‐L isomers, but not hte L‐L and D‐D isomers, showed fairly large up field shifts (0.2–0.4 ppm) of Leu‐βCH₂ and γCH proton signals, indicating the presence of shielding effects from the benzene ring. In addition to distinct signal splitting of Phe‐βCH₂, the NOE enhancement observed between Leu‐δCH₃ and Phe‐phenyl groups revealed that these groups are in close proximity. These data indicated that L‐D and D‐L isomers from a hydrophobic core between side chains of adjacent Leu and Phe residues. When the dipeptides were examined for inhibition of chymotrypsin using Ac‐Try‐OEt as a substrate, the L‐L isomer showed no inhibition, itself becoming a substrate. However, the other three isomers inhibited chymotrypsin in a competitive manner, and the D‐L isomer was strongest with K_i of 2.2 × 10₋₅ M. It was found that the D‐L isomer was only slowly hydrolysed but the L(or D)‐D isomer was not. H‐D‐Phe‐L‐Leu‐OBzl with the inverse sequence of H‐D‐Leu‐L‐Pre‐OBzl inhibited chymotrypsin more strongly (K_i = 6.3 × 10⁻⁶ M). Since the free acid analogue of the D‐L isomer exhibited no inhibition, the benzyl ester moiety itself was thought to be involved in the enzyme inhibition. It is assumed that in the inhibitory conformation the ester‐benzyl group fits the S₁ site of chymotrypsin, while the side chain‐side chain complexing hydrophobic core fits the S₂ site.

DOI： 10.1002/jmr.300060207
Enhancement of thrombin receptor activation by thrombin receptor-derived heptapeptide with para-fluorophenylalanine in place of phenylalanine Reviewed

Takeru Nose, Yasuyuki Shimohigashi, Motonori Ohno, Tommaso Costa, Naokata Shimizu, Yoshio Ogino

Biochemical and Biophysical Research Communications 193 ( 2 ) 694 - 699 1993.6

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1006/bbrc.1993.1680
Occurrence of an allosteric transition in the modification of papain withl-1-acetyl-2,3-dihydropyrrolo[2,3-b]-indole-2-carboxamide Reviewed

Akinori Nagatomo, Kohta Sakai, Takeru Nose, Yasuyuki Shimohigashi, Motonori Ohno

Journal of Chromatography A 597 ( 1-2 ) 411 - 413 1992.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1016/0021-9673(92)80138-K

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Books

アクティブ・ラーナーを育む　新時代を拓く基幹教育

飯嶋裕治、谷口説男、野瀬　健編木村政伸、石井祐子、梶原健佑、武田友加（ Role： Edit）

九州大学出版 2020.4

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Language：Japanese Book type：Scholarly book

Presentations

Structure and Function of the Elastin-like Short Peptide Analogs with Shuffled Sequences Based on (FPGVG)5 International conference

#Daiki Tatsubo, Keitaro Suyama, @Iori Maeda, Takeru Nose

10th International Peptide Symposium 2018.12

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Event date： 2018.12

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Development of Self-assembling Short Elastin-derived Peptide Analogs: Linear and Nonlinear (FPGVG)n Analogs International conference

Keitaro Suyama, #Daiki Tatsubo, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

10th International Peptide Symposium 2018.12

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Event date： 2018.12

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
エストロゲン受容体α型のリガンド認識におけるLeu387残基の構造要因

野瀬健、村田聡史、下東康幸

第33回日本分子生物学会年会・第83回日本生化学会大会　合同大会(BMB2010) 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド（神戸市） Country：Japan
In Silico Screening of Endocrine Disrupting Chemicals for Estrogen Receptor: A Novel Docking Method for Estimation of Binding and Biological Activities International conference

Takeru Nose and Yasuyuki Shimohigashi

2009.5

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Event date： 2009.5

Presentation type：Oral presentation (general)

Country：Korea, Republic of
A novel sophisticated screening method to estimate the nuclear receptor activities of endocrine disrupting chemicals Invited International conference

Takeru Nose

The 4th Pukyong University-Kyushu University Joint Symposium on Sciences 2009.3

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Event date： 2009.3

Presentation type：Oral presentation (general)

Country：Japan
π (pai) Interaction Important in Molecular Recognition by Receptor Protein International conference

2006.7

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
核内受容体ヘリックス１２の構造変化に着目した化学物質リスク評価法 Invited

野瀬　健

第6回ペプチドフォーラム 2005.2

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Presentation type：Oral presentation (general)

Venue：札幌 Country：Japan
温度応答性エラスチン様ペプチド・(FPGVG)5アナログの環境中に存在する芳香族化合物への結合特性

巣山慶太郎、#村島幹征、@前田衣織、野瀬　健

第９６回日本生化学会 2024.10

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Event date： 2024.10 - 2024.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市国際会議場、マリンメッセ Country：Japan
アンモニア-Ugi反応を用いたエラスチン様ペプチドアナログの合成

@友原啓介、#草場智、#田中尚輝、野瀬健

日本薬学会第144年会 2024.3

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Event date： 2024.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：パシフィコ横浜（横浜市） Country：Japan
Regulation of self-assembly ability of short-chain elastin-like peptide (FPGVG)n-azobenzene conjugates by light irradiation

Keitaro Suyama, Iori Maeda, Takeru Nose

2024.3

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Event date： 2024.3

Language：English Presentation type：Oral presentation (general)

Country：Japan
N-保護アミノ酸アンモニウムを用いた非天然型α,α-2置換アミノ酸含有ジペプチドの合成

＃草場智、友原啓介、野瀬健

第３９回日本薬学会九州山口支部大会 2023.11

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Event date： 2023.11

Language：Japanese

Venue：第一薬科大学薬学部新館東大教室 Country：Japan
Preparation of elastic material consisting of water-soluble elastin and other biological components

@Iori Maeda, @Kouki Nakamura, @Riku Wakamatsu, @Ayako Tani, @Noriko Watanabe, Takeru Nose

2023.11

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Event date： 2023.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
Light-induced modification of self-assembly in azobenzene-conjugated short elastin-like peptides

2023.11

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Event date： 2023.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
Temperature-responsive behavior of branched molecules bearing pentapeptide units of elastin-like peptide (FPGVG)n

2023.11

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Event date： 2023.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
Synthesis of thermoresponsive elastin-like peptide analogs by peptide fragment condensation reaction using papain

2023.11

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Event date： 2023.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
立体配座固定型アミノ酸残基を含有するジペプチドのα-キモトリプシン阻害活性

#草場智, 友原啓介, 野瀬健

第９６回日本生化学会 2023.10

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Event date： 2023.10 - 2023.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市国際会議場、マリンメッセ Country：Japan
繰り返し配列からなる温度応答性エラスチン様ペプチドの可溶性担体とフラグメント縮合による調製

巣山慶太郎, #吉田耕平, #松下　伸, @前田衣織, 野瀬　健

第９６回日本生化学会 2023.10

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Event date： 2023.10 - 2023.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市国際会議場、マリンメッセ Country：Japan
短鎖エラスチン様ペプチドを用いた化学修飾が引き起こすウシ血清アルブミンの温度応答性

#宗　玲那, 巣山慶太郎, @谷口　卓, @前田衣織, 野瀬　健

第９６回日本生化学会 2023.10

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Event date： 2023.10 - 2023.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市国際会議場、マリンメッセ Country：Japan
ブタ大動脈エラスチン含有物の調製方法の検討

＠中原崇希・＠前田衣織・野瀬健・＠谷口卓

第１３回　CSJ化学フェスタ2023 2023.10

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Event date： 2023.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：タワーホール船堀（東京都江戸川区） Country：Japan
Phe含有短鎖エラスチン様ペプチドによる化学修飾がもたらすウシ血清アルブミンへの温度応答性

#宗　玲奈、巣山慶太郎、@谷口　卓、@前田衣織、野瀬　健

令和5年度日本生化学会九州支部例会 2023.6

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Event date： 2023.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：長崎大学文教キャンパス Country：Japan
短鎖エラスチン様ペプチド・(FPGVG)5アナログの可逆的自己集合に対する芳香族化合物の影響

巣山慶太郎、#村島幹征、@前田衣織、野瀬　健

令和5年度日本生化学会九州支部例会 2023.6

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Event date： 2023.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：長崎大学文教キャンパス Country：Japan
アンモニア-Ugi反応の開発および非天然型α,α-２置換アミノ酸含有ペプチドのde novo合成への応用

#草場智, 友原啓介, 野瀬健

日本薬学会第143年会 2023.3

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Event date： 2023.3 - 2023.4

Language：Japanese Presentation type：Oral presentation (general)

Venue：北海道大学 Country：Japan
Regulation of reversible self-assembly ability by substitution and deletion of amino acid residues of elastin peptide (FPGVG)n analogs

Keitaro Suyama, #Shogo Sumiyoshi, #Marin Shimizu, #Naoki Tanaka, Keisuke Tomohara, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

2023.3

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Event date： 2023.3

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
エラスチン様ペプチド・(FPGVG)5の温度依存的自己凝集に対する芳香族化合物の影響

巣山慶太郎、#村島幹征、＠前田衣織、野瀬健

第9５回日本生化学会 2022.11

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Event date： 2022.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：名古屋市名古屋国際会議場 Country：Japan
Aromatic compounds scavenging ability of thermo-responsive short elastin-like peptide (FPGVG)n analogs

Keitaro Suyama, #Masayuki Murashima, @Iori Maeda, Takeru Nose

2022.10

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Event date： 2022.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Phe含有短鎖型エラスチン様ペプチドの結合によるウシ血清アルブミンへの温度応答性の付与

＃宗玲奈, 野瀬健

第５９回化学関連支部合同九州大会 2022.7

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Event date： 2022.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市小倉北区） Country：Japan
パパインを用いた水溶液中でのエラスチン様ポリペプチド (FPGVG)n の合成

＃長田晃彦, 野瀬健

第５９回化学関連支部合同九州大会 2022.7

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Event date： 2022.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市小倉北区） Country：Japan
温度応答性ペプチド・(FPGVG)5の配列短縮による自己集合能の増強

巣山慶太郎、#住吉勝伍、#田中尚輝、#安藤拓海、#長田晃彦、友原啓介、@谷口卓、@前田衣織、野瀬　健

令和4年度日本生化学会九州支部例会 2022.6

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Event date： 2022.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
ERα-アゴニストである新世代ビスフェノールのERβ-アンタゴニスト活性の原動力はLondon分散力である

@劉暁輝，巣山慶太郎，鳥飼浩平，#松山祐昂，野瀬健，@下東美樹，下東康幸

環境化学物質３学会合同大会 2022.6

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Event date： 2022.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：富山国際会議場 Country：Japan
エストロゲン受容体に強く結合する新世代ビスフェノールの神経モデル細胞を用いた影響解析

#多田悠亮，#白根共太，#荒巻光汰，#岩本雅輝，#枡屋宇洋，#細瀬摩利，#石橋知佳，巣山慶太郎，野瀬健，松島綾美

環境化学物質３学会合同大会 2022.6

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Event date： 2022.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：富山国際会議場 Country：Japan
短鎖エラスチン由来ペプチド(FPGVG)nの多量体化による温度応答性を有する機能性分子素材の開発

巣山慶太郎、#馬渡弥佳、＠前田衣織、野瀬健

第９４回日本生化学会 2021.11

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Event date： 2021.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
Development of Temperature-responsive Short-chain Peptide Analogues Based on Elastin-like Peptide FPGVG

Keitaro Suyama, #Shogo Sumiyoshi, #Naoki Tanaka, #Takumi Ando, #Akihiko Nagata, Keisuke Tomohara, @Suguru Taniguchi, @Iori Maeda, Takeru Nose

2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Development of Temperature-responsive Peptides by EDTA-mediated Multimerization of Short (FPGVG)n Chains

#Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, @Iori Maeda, Takeru Nose

2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
ハイブリッド型天然物様Ugi付加体の一斉化学合成

友原啓介,＃大橋奈央,野瀬　健

天然薬物の開発と応用シンポジウム 2021.10

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Event date： 2021.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
エストロゲン受容体αとオーファン核内受容体Nurr1に結合する合成コアクチベータペプチドの合理的設計

＃田川幸樹、巣山慶太郎、＃袈裟丸仁志、＃枡屋宇洋、野瀬健、松島綾美

第93回日本生化学会大会 2021.9

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Event date： 2021.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
3,5-ジアルキルオキシベンジルアルコールを可溶性担体として用いた温度応答性ペプチドの合成

#吉田耕平, 野瀬　健

第５８回化学関連支部合同九州大会 2021.7

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Event date： 2021.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
EDTAを用いた短鎖(FPGVG)n多量体の合成および温度応答性

#田中尚輝, 野瀬健

第５８回化学関連支部合同九州大会 2021.7

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Event date： 2021.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
金属結合性配列を導入した短鎖エラスチン様ペプチドアナログの金属結合性

#田中尚輝、住吉勝伍、巣山慶太郎、友原啓介、@前田衣織、野瀬健

令和 3 年度日本生化学会九州支部例会 2021.6

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Event date： 2021.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
有害環境化学物質ビスフェノール C 構造に基づく新規なエストロゲン受容体阻害剤

#岩本雅輝、巣山慶太郎、野瀬健、松島綾美

令和 3 年度日本生化学会九州支部例会 2021.6

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Event date： 2021.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
薬用植物抽出物を基質としたUgi反応による天然物連結型分子の合成

友原啓介、#大橋奈央、野瀬健

日本化学会　第101春期年会（2021） 2021.3

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Event date： 2021.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
エラスチン様ペプチド(FPGVG)5のフェニルアラニン残基のチロシン置換が自己集合能と構造変化に及ぼす影響

#清水真凛、巣山慶太郎、@前田衣織、野瀬健

日本化学会九州支部秋期研究発表会 2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
天然物抽出物を基質としたUgi反応の開発

#大橋奈央、友原啓介、野瀬健

日本化学会九州支部秋期研究発表会 2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
Role of Phe residues in elastin-like peptide (FPGVG)₅ on self-assembly properties

Keitaro Suyama, #Marin Shimizu, @Iori Maeda, Takeru Nose

2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Design and synthesis of a universal coactivator peptide binding to the estrogen receptor and NURR1

#Koki Tagawa, Keitaro Suyama, Hitoshi Kesamaru, #Takahiro Masuya, Takeru Nose, Ayami Matsushima

2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Development of self-aggregating elastin-like peptide analogs with a metal-binding sequence

#Shogo Sumiyoshi, Keitaro Suyama, Takeru Nose

2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Fractionation of water-soluble elastin from pig aorta by coacervation method

@Iori Maeda, @Suguru Taniguchi, @Yumi Moriuchi, @Naruhiko Sawa, @Asako Inoue, @Tomoyuki Usa, @Noriko Watanabe, Keitaro Suyama, Takeru Nose

2020.11

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Event date： 2020.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
薬用植物エキストラクトを起点とした非天然アミノ酸誘導体の一斉合成

#大橋奈央、友原啓介、野瀬健

第117回有機合成シンポジウム2020年 2020.10

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Event date： 2020.10

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン開催 Country：Japan
九州大学のオンライン授業に関する学生アンケート（春学期）について

野瀬　健、長沼祥太郎

第12回4月からの大学等遠隔授業に化する取組状況共有サイバーシンポジウム 2020.7

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Event date： 2020.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：オンライン Country：Japan
トリハロゲン化メチル基含有ビスフェノール：ERα-アゴニスト・ERβ-アンタゴニストの二価性活性の原動力はハロゲンに働く分散力である

＠劉暁輝、巣山慶太郎、志岐潤一、鳥飼浩平、野瀬健、＠下東美樹、下東康幸

令和２年度日本生化学会九州支部例会 2020.5

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Event date： 2020.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：誌上開催 Country：Japan
温度応答性ペプチド・(FPGVG)5のフェニルアラニン残基置換による自己集合特性への影響

巣山慶太郎、#清水真凜、＠谷口　卓、＠前田衣織、野瀬　健

令和２年度日本生化学会九州支部例会 2020.5

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Event date： 2020.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：誌上開催 Country：Japan
三環系ビスフェノールを用いたエストロゲン受容体アンタゴニストの戦略的設計合成

#岩本雅輝、巣山慶太郎、野瀬健、松島綾美

令和２年度日本生化学会九州支部例会 2020.5

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Event date： 2020.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：誌上開催 Country：Japan
Development of liposome-like nanostructures composed of short amphiphilic elastin-like peptides

#Naoki Sakamoto, #Daiki Tatsubo, #Keiji Sato, Keisuke Tomohara, Keitaro Suyama, @Iori Maeda, Takeru Nose

2019.10

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Event date： 2019.10

Language：English Presentation type：Oral presentation (general)

Country：Japan
Concentration dependent coacervation property of nonlinear elastin-derived peptide (FPGVG)n analogs

Keitaro Suyama, #Mika Mawatari, #Daiki Tatsubo, @Iori Maeda, Takeru Nose

2019.10

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Event date： 2019.10

Language：English Presentation type：Oral presentation (general)

Country：Japan
Stability of Phe-containing elastin-like peptides against proteases in digestive organs

@Iori Maeda, @Miki Kawakami, @Suguru Taniguchi, Keitaro Suyama, Takeru Nose

2019.10

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Event date： 2019.10

Language：English Presentation type：Oral presentation (general)

Country：Japan
エラスチン由来ペプチド(FPGVG)5のフェニルアラニン一残基置換の自己集合能への影響

巣山慶太郎, @宮崎真佐也, @前田衣織, #清水真凛, 野瀬健

第92回日本生化学会大会 2019.9

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Event date： 2019.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：パシフィコ横浜（横浜市） Country：Japan
新世代ビスフェノールのヒト核内受容体に対する結合活性

劉暁輝, 酒井大樹, #錦織充広, 巣山慶太郎, #縄司奨, #池田伸, #西垣内誠, #岡田浩幸, 松島綾美, 野瀬健, @下東美樹, 下東康幸

第92回日本生化学会大会 2019.9

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Event date： 2019.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：パシフィコ横浜（横浜市） Country：Japan
ビスフェノールAへの位置特異的ハロゲン置換が引き起こすエストロゲン受容体αおよびβに対する異なる結合性および転写活性の変化

#袈裟丸仁志, #金子周平, #大久保貴史, #笠谷和見, 巣山慶太郎, 劉暁輝, 松島綾美, 野瀬健

第92回日本生化学会大会 2019.9

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Event date： 2019.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：パシフィコ横浜（横浜市） Country：Japan
エラスチン由来ペプチド・(FPGVG)n ニトリロ三酢酸付加アナログの自己集合特性および金属結合性の解析

巣山慶太郎、#馬渡弥佳、#田坪大来、@前田衣織、野瀬健

平成31年度日本生化学会九州支部例会 2019.6

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：長崎大学(長崎市） Country：Japan
新世代ビスフェノールのヒト核内受容体に対するリスク評価

劉暁輝、酒井大樹、#錦織充広、巣山慶太郎、#縄司奨、#池田伸、#西垣内誠、#岡田浩幸、松島綾美、野瀬健、@下東美樹、下東康幸

平成31年度日本生化学会九州支部例会 2019.6

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Event date： 2019.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：長崎大学(長崎市） Country：Japan
ビスフェノールAのハロゲン化による核内受容体PPARγに対する結合性および生理活性への影響

#大久保　貴史, #袈裟丸　仁志, @劉　暁輝, @松島　綾美, @巣山　慶太郎, @野瀬　健

日本化学会第99春季年会2019 2019.3

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Event date： 2019.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：甲南大学　岡本キャンパス Country：Japan
ビスフェノールAのハロゲン化によるHeLa細胞に対する細胞増殖活性・細胞毒性の変化

#袈裟丸仁志, #金子周平, #大久保貴史, #笠谷和見, 巣山慶太郎, 野瀬健

環境ホルモン学会 2018.12

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Event date： 2018.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：東洋大学白山キャンパス（東京都文京区） Country：Japan
Mechanistic Characterization of α-Chymotrypsin Inhibitors by DMSO-Perturbing Assay International conference

2018.12

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Event date： 2018.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：ROHM Theatre Kyoto and Miyakomesse (Kyoto） Country：Japan
エストロゲン受容体βと有害環境化学物質・ビスフェノール類縁体の新規結合様式解析と結合能評価

#枡屋宇洋、#岩本雅輝、劉暁輝、袈裟丸仁志、野瀬　健、松島綾美

第91回日本生化学会大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
ハロゲン置換ビスフェノールAアナログのHeLa細胞に対する細胞毒性

#袈裟丸仁志,# 金子周平, #大久保貴史, #笠谷和見, 巣山慶太郎, 野瀬健

第91回日本生化学会大会 2018.9

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Event date： 2018.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
DMSO 添加条件下における酵素阻害剤の活性部位特異性評価

友原啓介、＠足立伊佐雄、#袈裟丸仁志、野瀬健

平成30年度日本生化学会九州支部例会 2018.6

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Event date： 2018.6 - 2018.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：九州大学医学部百年講堂(福岡市） Country：Japan
ビスフェノール A へのハロゲン原子の導入が引き起こすエストロゲン関連受容体γ型への結合性および生物活性への影響の評価

＃袈裟丸仁志、＃金子周平、＃大久保貴史、＃笠谷和見、劉暁輝、巣山慶太郎、松島綾美、野瀬健

平成30年度日本生化学会九州支部例会 2018.6

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Event date： 2018.6 - 2018.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：九州大学医学部百年講堂(福岡市） Country：Japan
エラスチン様ペプチド(FPGVG)5の脂肪酸付加アナログを用いたリポソーム様凝集体形成

#坂本直樹, #田坪大来, 巣山慶太郎, @前田衣織, 野瀬健

第55回化学関連支部合同九州大会 2018.6

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場(北九州市） Country：Japan
ハロゲン化ビスフェノールAの核内受容体RORγに対する結合親和性のドッキング計算および結合試験による評価

#笠谷和見, #袈裟丸仁志, #金子周平, #大久保貴史, 巣山慶太郎, 劉暁輝, 松島綾美, 野瀬健

第55回化学関連支部合同九州大会 2018.6

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Event date： 2018.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場(北九州市） Country：Japan
Self-association and metal binding properties of novel trimeric analogs of elastin-derived peptide (FPGVG)n

#Mika Mawatari, #Daiki Tastubo, Keitaro Suyama, @Iori Maeda, Takeru Nose

2018.3

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Event date： 2018.3

Language：English Presentation type：Oral presentation (general)

Country：Japan
The self-assembly properties of elastin-derived (FPGVG)n peptide analogs aiming for development of basic materials as pH- and temperature-responsive hydrogels

Keitaro Suyama, #Daiki Tatsubo, Iori Maeda, Takeru Nose

2018.3

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Event date： 2018.3

Language：English Presentation type：Oral presentation (general)

Country：Japan
基幹教育におけるアクティブラーナーの育成を目指した科目開発～リベラルサイエンス科目開発の可能性～

野瀬　健

「第4回基幹教育シンポジウム」新たな教養教育の実践と課題～科目開発の実際とその評価を中心に～ 2017.12

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：九州大学西新プラザ大会議室 Country：Japan
エストロゲン受容体へのビスフェノールAの結合性および転写活性に対する芳香環ハロゲン化の影響解析

#袈裟丸仁志、#金子周平、#大久保貴史、#笠谷和見、巣山慶太郎、#枡屋宇洋、劉　暁輝、松島綾美、野瀬　健

第２０回環境ホルモン学会 2017.12

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸大学百年記念館六甲ホール（神戸市） Country：Japan
Effects of halogen substitution of bisphenol A on binding and activation property against ERα

生命科学系学会合同年次大会（第40回日本分子生物学会年会、第90回日本生化学会大会合同大会 2017.12

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド（神戸市） Country：Japan
The binding ability of newly utilized bisphenol derivatives to human estrogen receptor beta

#Takahiro Masuya, #Yuta Hazama, Xiaohui Liu, #Hitoshi Kesamaru, Takeru Nose, Ayami Matsushima

2017.12

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Event date： 2017.12

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
温度依存的自己凝集性ペプチド(FPGVG)_nの三量体合成と凝集性の解析

#馬渡弥佳,#田坪大来,巣山慶太郎,野瀬健

第54回化学関連支部合同九州大会 2017.7

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Event date： 2017.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
魚由来組織からのエラスチン精製における条件検討

@角銅宏一郎,@宇佐友行,@井上亜沙子,@谷口卓,野瀬健,@前田衣織

第54回化学関連支部合同九州大会 2017.7

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Event date： 2017.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
ビスフェノールAのハロゲン化が核内受容体PPARγへの結合性におよぼす影響

#大久保貴史,#金子周平,劉暁輝,松島綾美,#袈裟丸仁志,巣山慶太郎,野瀬健

第54回化学関連支部合同九州大会 2017.7

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Event date： 2017.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
環状合成ペプチド・Cyc-(FPGVG)n の自己集合特性の解析

巣山慶太郎、#田坪大来、#袈裟丸仁志、@前田衣織、野瀬健

平成２9年度日本生化学会九州支部例会 2017.5

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Event date： 2017.5 - 2016.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮崎大学（宮崎市） Country：Japan
エラスチン由来ペプチド(FPGVG)₅ アナログの自己集合における塩および pH の影響

#田坪大来、#児玉美佐子、巣山慶太郎、@前田衣織、野瀬健

平成２9年度日本生化学会九州支部例会 2017.5

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Event date： 2017.5 - 2016.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮崎大学（宮崎市） Country：Japan
in vitro, in silico の手法を用いたハロゲン化ビスフェノールの核内受容体 ERs, ERRγ, PPARγ に対する結合性の評価

#袈裟丸仁志、#金子周平、#大久保貴史、巣山慶太郎、劉暁輝、松島綾美、野瀬健

平成２9年度日本生化学会九州支部例会 2017.5

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Event date： 2017.5 - 2016.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：宮崎大学（宮崎市） Country：Japan
エラスチン由来ペプチド(FPGVG)nおよび(WPGVG)nの環状化アナログの凝集特性および立体構造解析

巣山慶太郎, 袈裟丸仁志, 田坪大来, 前田衣織, 野瀬健

日本化学会第９7春期年会 2017.3

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Event date： 2017.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：慶應義塾大学日吉キャンパス Country：Japan
The effects of halogenation of bisphenol A on binding affinity to nuclear receptor ERRγ

金子周平, 大久保貴史, 劉暁輝, 松島綾美, 袈裟丸仁志, 巣山慶太郎, 野瀬健

日本化学会第９7春期年会 2017.3

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Event date： 2017.3

Language：English Presentation type：Oral presentation (general)

Venue：慶應義塾大学日吉キャンパス Country：Japan
ビスフェノールAの芳香環ハロゲン置換が核内受容体ERRγへの結合性におよぼす影響の評価

袈裟丸仁志, 金子周平, 大久保貴史, 巣山慶太郎, 劉暁輝, 松島綾美, 野瀬健

環境ホルモン学会第１9回研究発表会 2016.12

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Event date： 2016.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：文部科学省研究交流センター Country：Japan
Effects of salts and pH on coacervation of short elastin-like peptide (FPGVG)₅

#Daiki Tatsubo, #Misako Kodama, #Keiji Sato, Keitaro Suyama, @Iori Maeda, Takeru Nose

2016.11

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Event date： 2016.11

Language：English Presentation type：Oral presentation (general)

Country：Japan
Coacervation Property and Structural Analysis of Cyclic Analogs of Elastin-derived Peptide (FPGVG)n

2016.10

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Event date： 2016.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Analysis of structural requirement for coacervation property of elastin model peptide dimers

2016.10

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Event date： 2016.10

Language：English Presentation type：Oral presentation (general)

Country：Japan
ハロゲン化BPAとERRγの結合における相互作用のin vitroおよびin silico解析

金子周平, 巣山慶太郎, 劉暁輝, 松島綾美, 野瀬健

第８9回日本生化学会大会合同大会 2016.9

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Event date： 2016.9 - 2014.9

Language：Japanese Presentation type：Oral presentation (general)

Venue：仙台国際センター Country：Japan
ビスフェノールAのハロゲン修飾がERRγへの結合性に及ぼす影響

金子周平, 巣山慶太郎, 袈裟丸仁志, 野瀬健

第53回化学関連支部合同九州大会 2016.7

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Event date： 2016.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場 Country：Japan
計算的手法を用いた酵素キモトリプシンのペプチド性阻害剤の分子設計における弱い相互作用の影響

袈裟丸仁志, 巣山慶太郎, 野瀬健

平成２8年度日本生化学会九州支部例会 2016.5

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Event date： 2016.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島大学 Country：Japan
ダイマー化エラスチン由来ペプチド(C(WPGVG)3)2のコアセルベーションにおける段階的な自己集合過程

田坪大来, 巣山慶太郎, 野瀬健

平成２8年度日本生化学会九州支部例会 2016.5

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Event date： 2016.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：鹿児島大学 Country：Japan
無機塩水溶液中におけるエラスチン由来ペプチド(FPGVG)nアナログのコアセルベーション特性

兒玉美佐子, 巣山慶太郎, 前田衣織, 野瀬健

日本化学会第９6春期年会 2016.3

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Event date： 2016.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：同志社大学京田辺キャンパス Country：Japan
エラスチン由来ペプチド(C(WPGVG)3)2の段階的微小凝集体形成機構

田坪大来, 巣山慶太郎, 野瀬健

日本化学会第９6春期年会 2016.3

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Event date： 2016.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：同志社大学京田辺キャンパス Country：Japan
化学物質のエストロゲン受容体αおよびβに対する結合性予測計算における受容体構造の影響

袈裟丸仁志, 巣山慶太郎, 野瀬健

日本化学会第９6春期年会 2016.3

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Event date： 2016.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：同志社大学京田辺キャンパス Country：Japan
エラスチン由来ペプチド(FPGVG)5の蛍光標識アナログの凝集特性および立体構造解析

巣山慶太郎, 袈裟丸仁志, 田坪大来, 野瀬健

日本化学会第９6春期年会 2016.3

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Event date： 2016.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：同志社大学京田辺キャンパス Country：Japan
エラスチンペプチドアナログ(FPGVG)5の自己集合特性にN末端修飾がおよぼす影響

佐藤圭治, 巣山慶太郎, 野瀬健

日本化学会第９6春期年会 2016.3

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Event date： 2016.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：同志社大学京田辺キャンパス Country：Japan
計算化学的手法を用いたエストロゲン受容体ERαおよびERβに対する化学物質の結合性および受容体活性予測における受容体構造の及ぼす影響の評価

袈裟丸仁志, 巣山慶太郎, 野瀬健

環境ホルモン学会第１７回研究発表会 2015.12

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Event date： 2015.12 - 2014.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：自治医科大学地域医療情報研修センター Country：Japan
エラスチン分解物によるアンジオテンシン変換酵素の阻害

行武公彦, 原田達郎, 甲斐捷平, 谷口卓, 野瀬健, 前田衣織

第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド Country：Japan
蛍光標識したエラスチン由来ペプチドの自己凝集および蛍光特性の解析

巣山慶太郎, 袈裟丸仁志, 田坪大来, 野瀬健

第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド Country：Japan
ドッキング計算を用いた化学物質の核内受容体結合リスク評価における鋳型構造の影響

袈裟丸仁志, 野瀬健

第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド Country：Japan
エラスチン由来ペプチドからのACE阻害ペプチドの探索

原田達郎, 甲斐捷平, 谷口卓, 野瀬健, 前田衣織

第38回日本分子生物学会年会・第88回日本生化学会大会合同大会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド Country：Japan
Identification of an elastin-derived peptide degradate in human blood after oral ingestion of elastin

2015.11

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Coacervation Properties and Structural Analysis of Aminobenzoyl-labeled Fluorescent Elastin-derived Peptides

2015.11

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Fluorescence Analysis Using a Molecular Probe 1,8-ANS for Elucidation of the Molecular Mechanisms Underlying Coacervation of a Tryptophan-containing Elastin derived Dimeric Peptide

2015.11

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Event date： 2015.11

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
エラスチン由来ペプチドのヒト3次元培養皮膚に対する効果

井上亜沙子, 引間知広, 野瀬　健, 前田衣織

第31回日本DDS学会学術集会 2015.7

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Event date： 2015.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：京王プラザホテル Country：Japan
自己集合性ペプチド(FPGVG)nアナログの無機塩水溶液中における凝集特性

兒玉美佐子, 袈裟丸仁志, 巣山慶太郎, 野瀬健

第52回化学関連支部合同九州大会 2015.6

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場 Country：Japan
自己集合性ペプチド(FPGVG)nアナログのN末端脂肪酸修飾が及ぼす凝集特性への影響

佐藤圭治, 田坪大来, 巣山慶太郎, 前田衣織, 野瀬健

第52回化学関連支部合同九州大会 2015.6

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Event date： 2015.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場 Country：Japan
アミノベンゾイル基で標識されたエラスチン由来蛍光ペプチドの物性解析

巣山慶太郎, 袈裟丸仁志, 田坪大来, 野瀬健

平成２7年度日本生化学会九州支部例会 2015.5

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Event date： 2015.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：九州大学 Country：Japan
Bioactivity and nutritional evaluation of housefly larvae International conference

Hujun Li, Asako Inoue, Suguru Taniguchi, Tomohiko Yukutake, Takeru Nose, Keitaro Suyama, Yasuharu Nakano, Ryohei Maeda, Iori Maeda

ACN2015 12th Asian Congress of Nutrition 2015.5

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Event date： 2015.5

Language：English

Country：Japan
キモトリプシンのトリペプチド阻害剤の分子設計における計算化学的手法の導入

袈裟丸仁志, 巣山慶太郎, 野瀬健

日本化学会第９５春期年会 2015.3

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Event date： 2015.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：日本大学理工学部船橋キャンパス Country：Japan
エラスチン由来ペプチド(FPGVG)nダイマーの自己集合特性および構造解析

巣山慶太郎, 谷口卓, 田坪大来, 前田衣織, 野瀬健

日本化学会第９５春期年会 2015.3

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Event date： 2015.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：日本大学理工学部船橋キャンパス Country：Japan
トリプトファンを有するエラスチン様ペプチドの自己集合特性の解析

田坪大来, 巣山慶太郎, 谷口卓, 前田衣織, 野瀬健

日本化学会第９５春期年会 2015.3

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Event date： 2015.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：日本大学理工学部船橋キャンパス Country：Japan
Inhibition of Angiotensin-converting Enzyme by Water-soluble Elastin Prepared with the Alkali Hydrolysis Method International conference

Shohei Kai, Suguru Taniguchi, Asako Inoue, Tatsuro Harada, Takeru Nose, Iori Maeda

2nd International Symposium on Applied Engineering and Sciences (SAES2014) 2014.12

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Event date： 2014.12

Language：English Presentation type：Oral presentation (general)

Country：Japan
計算化学的手法による化学物質の ERα結合性予測における受容体構造の重要性

袈裟丸仁志, 野瀬健

環境ホルモン学会第１７回研究発表会 2014.12

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Event date： 2014.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
Structure-function relationships of spinoxin, a peptide neurotoxin from scorpion venom

2014.10

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Event date： 2014.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Coacervation property and structural analysis of synthetic dimer peptides of aromatic amino acid containing elastin-derived peptides

2014.10

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Event date： 2014.10

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
Effects of Dimerization of the Synthetic Peptide (FPGVG)n on Its Coacervation Property

2014.9

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Event date： 2014.9

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
フェニルアラニンを導入したエラスチン由来ペプチドのコアセルベーション

谷口卓, 巣山慶太郎, 野瀬健, 前田衣織

日本エラスチン研究会　第11回　学術集会 2014.7

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Event date： 2014.7

Language：Japanese Presentation type：Oral presentation (general)

Venue：私学会館　（アルカディア市ヶ谷） Country：Japan
計算的手法を用いたキモトリプシンのトリペプチド性インヒビターの分子設計

袈裟丸仁志, 巣山慶太郎, 野瀬健

第５１回化学関連支部合同九州大会 2014.6

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Event date： 2014.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場 Country：Japan
エラスチン配列由来芳香族アミノ酸含有合成ペプチドの温度依存的な自己集合凝集特性の解析

田坪大来, 巣山慶太郎, 谷口卓, 前田衣織, 野瀬健

第５１回化学関連支部合同九州大会 2014.6

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Event date： 2014.6

Language：Japanese Presentation type：Oral presentation (general)

Venue：北九州国際会議場 Country：Japan
エラスチン由来ダイマーペプチドのコアセルベーション特性の解析

巣山慶太郎, 谷口　卓, 田坪大来, 前田衣織, 河野敬一, 野瀬健

平成２６年度日本生化学会九州支部例会 2014.5

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Event date： 2014.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：九州大学 Country：Japan
エラスチン由来ペプチドダイマーの自己集合特性および立体構造の解析

巣山慶太郎、野瀬　健、谷口　卓、前田衣織、河野敬一

分子・物質合成プラットフォーム平成25年度シンポジウム 2014.3

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Event date： 2014.3

Presentation type：Oral presentation (general)

Venue：筑波国際会議場（つくば市） Country：Japan
ヒト核内受容体の計算化学研究展開

野瀬健

リスクサイエンス研究フォーラム2013 2014.3

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Event date： 2014.3

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
核内受容体COUP-TFsに対する環境化学物質のスクリーニング

木村僚子、劉暁輝、松島綾美、野瀬健、下東康幸

第16回環境ホルモン学会研究発表会 2013.12

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Event date： 2013.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
核内受容体Rev-erbβに結合するリガンドのSPR法による探索

山口智裕、劉暁輝、松島綾美、野瀬健、下東康幸

第16回環境ホルモン学会研究発表会 2013.12

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Event date： 2013.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
Functionally essential amino acid residues in nociceptin:ORL1 ligand-receptor activation International conference

Hirokazu Nishimura, Jinglan Li, Kaname Isozaki, Yoshinori Abe, Shogo Inamine, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi

4th Asia-Pacific International Peptide Symposium (APIPS) 50th Japanese Peptide Symposium (JPS) 2013.11

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Event date： 2013.11

Presentation type：Oral presentation (general)

Country：Japan
Coacervation Property and Secondary Structure of Synthetic Dimer Peptides of Elastin-derived Pentapeptide Repeats International conference

Keitaro Suyama, Suguru Taniguchi, Iori Maeda, Daiki Tatsubo, Takeru Nose

4th Asia-Pacific International Peptide Symposium (APIPS) 50th Japanese Peptide Symposium (JPS) 2013.11

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Event date： 2013.11

Presentation type：Oral presentation (general)

Country：Japan
Structure-activity studies on the halogenated Phe-containing neuropeptide substance P analogs International conference

4th Asia-Pacific International Peptide Symposium (APIPS) 50th Japanese Peptide Symposium (JPS) 2013.11

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Event date： 2013.11

Presentation type：Oral presentation (general)

Country：Japan
ダイマー界面に存在するリシンクラスターが保証するヒト核内受容体ERRγの自発活性

藤山明菜、劉暁輝、松島綾美、野瀬健、下東康幸

第86回日本生化学会大会 2013.9

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Event date： 2013.9

Presentation type：Oral presentation (general)

Venue：パシフィコ横浜、横浜市 Country：Japan
エストロゲン関連受容体γ型のビスフェノールＡ特異的結合における構造要因

劉　暁輝、松島綾美、野瀬　健、下東美樹、下東康幸

第86回日本生化学会大会 2013.9

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Event date： 2013.9

Presentation type：Oral presentation (general)

Venue：パシフィコ横浜、横浜市 Country：Japan
オーファン核内受容体LRH-1はロイコトリエンに特異的結合する受容体である

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

第86回日本生化学会大会 2013.9

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Event date： 2013.9

Presentation type：Oral presentation (general)

Venue：パシフィコ横浜、横浜市 Country：Japan
Influence analyses of the expression levels and nucleotide sequences of fetal brain nuclear receptor mRNAs in mice exposed to bisphenol A

Makiko Sugiyama, Tatsuya Saito, Eriko uchimura, Ayami Matsushima, Ayaka Matsuo, Keita Koga, Masayuki Nakamura, Tasuku Nawaji, Miho Sumiyoshi, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi

2013.9

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Event date： 2013.9

Presentation type：Oral presentation (general)

Country：Japan
Three-dimensional bisphenol A docking modeling for exploration of target nuclear receptors

2013.9

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Event date： 2013.9

Presentation type：Oral presentation (general)

Country：Japan
核内受容体COUP-TF1に対する環境化学物質のSPRスクリーニング

木村僚子、劉暁輝、松島綾美、野瀬健、下東康幸

第50回化学関連支部合同九州大会 2013.7

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Event date： 2013.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
核内受容体結合試験の新規プローブの開発：蛍光標識ビスフェノールC

巣山慶太郎、劉　暁輝、松島綾美、野瀬　健、下東康幸

日本ケミカルバイオロジー学会　第8回年会 2013.6

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Event date： 2013.6

Presentation type：Oral presentation (general)

Venue：東京医科歯科大学、東京 Country：Japan
オーファン核内受容体LRH-1はロイコトリエンに特異的な受容体である

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

平成25年度日本生化学会九州支部例会 2013.5

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Event date： 2013.5

Presentation type：Oral presentation (general)

Venue：佐賀市（佐賀大学） Country：Japan
ヒト核内受容体ERRγ、CAR、PXRにおけるビスフェノールＡ結合構造の比較

松山祐昂、劉暁輝、西村裕一、松島綾美、野瀬健、下東康幸

平成25年度日本生化学会九州支部例会 2013.5

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Event date： 2013.5

Presentation type：Oral presentation (general)

Venue：佐賀市（佐賀大学） Country：Japan
核内受容体ERRγを自発活性に導くリシンクラスターのダイマー化への寄与

藤山明菜、劉暁輝、松島綾美、野瀬健、下東康幸

平成25年度日本生化学会九州支部例会 2013.5

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Event date： 2013.5

Presentation type：Oral presentation (general)

Venue：佐賀市（佐賀大学） Country：Japan
高精度NK-1 受容体結合試験系による高活性サブスタンスPアナログの検討

蔵満由美、西村裕一、中村諒、巣山慶太郎、松島綾美、野瀬健、下東康幸

平成25年度日本生化学会九州支部例会 2013.5

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Event date： 2013.5

Presentation type：Oral presentation (general)

Venue：佐賀市（佐賀大学） Country：Japan
ハロゲン含有ビスフェノールのエストロゲン受容体α型とβ型における異なる転写活性化

劉　暁輝、巣山慶太郎、志岐潤一、松島綾美、野瀬　健、下東美樹、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
ヒト核内受容体ERRγおよびCARにおけるビスフェノールA結合様式の異同

松山祐昂、劉暁輝、西村裕一、松島綾美、野瀬健、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
自発活性化型核内受容体ERRγ転写活性化を支えるダイマー形成に必須なリシンクラスター

藤山明菜、劉暁輝、松島綾美、野瀬健、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
鎮痛ペプチド・エンドモルフィン−２の構造を基盤としたアンタゴニストの設計と戦略

西尾華奈子、西村裕一、巣山慶太郎、野瀬健、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
オーファン核内受容体LRH-1はロイコトリエン受容体である

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
マウス胎仔脳・核内受容体mRNA遺伝子へのビスフェノールＡ暴露の影響

内村恵梨子、斎藤辰弥、松島綾美、杉山真季子、松尾文香、中村将行、縄司　奨、劉　暁輝、住吉美保、野瀬　健、下東美樹、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
内分泌撹乱物質探索のための受容体結合試験に用いる新規蛍光性プローブの開発

巣山慶太郎、劉　暁輝、松島綾美、野瀬　健、下東康幸

リスクサイエンス研究フォーラム2013 2013.3

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Event date： 2013.3

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
核内受容体ERRγを介したビスフェノールＡの内分泌撹乱作用の分子機構

下東康幸、劉暁輝、松島綾美、松尾文香、斎藤辰弥、内村恵梨子、中村将行、池田伸、野瀬健、下東美樹

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ビスフェノールＡ暴露マウス胎仔の脳内核内受容体mRNA遺伝子変異解析

内村恵梨子、斎藤辰弥、松島綾美、中村将行、縄司　奨、松尾文香、劉暁輝、住吉美保、野瀬　健、下東美樹、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
エストロゲン受容体α型とβ型へ異なる転写活性化を示すハロゲン含有ビスフェノール

劉　暁輝、巣山慶太郎、志岐潤一、松島綾美、野瀬　健、下東美樹、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ヒト・レチノイン受容体RARαに結合する化学物質のスクリーニング

野瀬健, #縄司　奨, 下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ヒト核内受容体ERRγおよびCARにおける異なるビスフェノールA相互作用様式

松山祐昂、劉暁輝、西村裕一、松島綾美、野瀬健、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ビスフェノールＡ受容体ERRγの転写活性化に必須なリシンクラスターを介したダイマー構造

藤山明菜、劉暁輝、松島綾美、野瀬健、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
オーファン核内受容体LRH-1に対する環境化学物質のスクリーニング

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
NBD標識ビスフェノールC：新規蛍光性プローブを用いた核内受容体結合試験系の開発

巣山慶太郎、劉暁輝、松島綾美、野瀬健、下東康幸

第15回環境ホルモン学会研究発表会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ハロゲン含有ビスフェノールのエストロゲン受容体サブタイプ特異的転写活性：α-アゴニズムおよびβ-アンタゴニズム

劉　暁輝、巣山慶太郎、松島綾美、野瀬　健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
核内受容体CAR・ビスフェノールA結合体のドッキングモデリングと結合サイトの同定

松山祐昂、劉暁輝、西村裕一、松島綾美、野瀬健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
エンドモルフィン−２はハロゲン導入によりアンタゴニストへ変化する

西尾華奈子、西村裕一、巣山慶太郎、野瀬健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
核内受容体ERRγのダイマー化インターフェイスに存在するリシンクラスター

藤山明菜、劉暁輝、松島綾美、野瀬健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
オーファン核内受容体LRH-1に対するSPRおよび結合試験によるリガンド探索

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
ビスフェノールA暴露マウスの胎仔脳核内受容体における遺伝子変異解析

内村恵梨子、斎藤辰弥、松島綾美、中村将行、縄司　奨、松尾文香、住吉美保、野瀬　健、下東美樹、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
核内受容体結合試験における蛍光プローブ・NBD標識ビスフェノールC

巣山慶太郎、劉暁輝、松島綾美、野瀬健、下東康幸

第85回日本生化学会大会 2012.12

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Event date： 2012.12

Presentation type：Oral presentation (general)

Venue：福岡国際会議場、マリンメッセ福岡（福岡市） Country：Japan
Halogenation of Phe-phenyl in Opioid Peptide Engdomorphin-2 for Invention of Antagonist International conference

Kanako Nishio, Hirokazu Nishimura, Keitaro Suyama, Ayami Matsushima, Takeru Nose, and Yasuyuki Shimohigashi

The 16th Korean Peptide and Protein Symposium 2012.11

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Event date： 2012.11

Presentation type：Oral presentation (general)

Country：Korea, Republic of
高活性サブスタンスPアナログに対する高精度NK1結合試験系

蔵満由美、西村裕一、中村　諒、巣山慶太郎、野瀬　健、下東康幸

第49回ペプチド討論会 2012.11

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Event date： 2012.11

Presentation type：Oral presentation (general)

Venue：かごしま県民交流センター（鹿児島） Country：Japan
高親和性ハロゲン化フェニルアラニン含有エンドモルフィン−２のアンタゴニスト活性

西尾華奈子、西村裕一、巣山慶太郎、松島綾美、野瀬　健、下東康幸

第49回ペプチド討論会 2012.11

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Event date： 2012.11

Presentation type：Oral presentation (general)

Venue：かごしま県民交流センター（鹿児島） Country：Japan
自発活性な核内受容体CARのビスフェノール結合ポケット：密充填ドッキングモデリング

松山祐昂、劉暁輝、西村裕一、松島綾美、野瀬健、下東康幸

第49回ペプチド討論会 2012.11

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Event date： 2012.11

Presentation type：Oral presentation (general)

Venue：かごしま県民交流センター（鹿児島） Country：Japan
オーファン核内受容体Rev-erbに対する化学物質結合性のSPR解析

山口智裕、野瀬　健、下東康幸

第49回化学関連支部合同九州大会 2012.6

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Event date： 2012.6

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
ハロゲン含有ビスフェノール類のエストロゲン受容体ERαおよびERβでのホルモン活性特性

劉暁輝、巣山慶太郎、松島綾美、野瀬健、下東康幸

平成24年度日本生化学会九州支部例会 2012.5

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Event date： 2012.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
ハロゲン化フェニルアラニンを用いた高活性エンドモルフィン−２アナログの創製

西尾華奈子、西村裕一、巣山慶太郎、野瀬　健、下東康幸

平成24年度日本生化学会九州支部例会 2012.5

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Event date： 2012.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
オーファン核内受容体LRH-1に対する高効率結合試験系の構築

佐々木彩也香、劉　暁輝、松島綾美、野瀬　健、下東康幸

平成24年度日本生化学会九州支部例会 2012.5

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Event date： 2012.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
疼痛ORL1受容体のＮ-エチルマレイミドCysラベリングによるノシセプチン結合の阻害

西村裕一、松尾文香、松島綾美、野瀬　健、Tommaso Costa、下東康幸

平成24年度日本生化学会九州支部例会 2012.5

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Event date： 2012.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
Nociceptin ORL1 Receptor Activation Requires Functionally Indefinite Receptor Amino Acid Residues International conference

Hirokazu Nishimura, Shogo Inamine, Ayami Matsushima, Takeru Nose and Yasuyuki Shimohigashi

2011.11

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Event date： 2011.11

Presentation type：Oral presentation (general)

Country：Japan
疼痛ノシセプチンORL1受容体のトリチウム標識純アンタゴニストの受容体結合特性

稲嶺翔吾、西村裕一、李　京蘭、松島綾美、野瀬　健、Tomasso Costa、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
δ-オピオイド受容体リガンド・デルトルフィンIIのダイマーによる受容体二価性構造の解析

伊藤夏希、西村裕一、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
疼痛ノシセプチン受容体ORL1のリガンド結合と受容体活性化に必須な構造要因

西村裕一、李　京蘭、磯崎　要、阿部由則、稲嶺翔吾、松島綾美、野瀬　健、Tomasso Costa、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
δオピオイド受容体の受容体活性化に必須なHis残基の機能解析

阿部由則、松尾崇史、西村裕一、李　京蘭、野瀬　健、Tommaso Costa、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
ショウジョウバエ時計タンパク質PERIODに含まれるThr-Glyリピートの構造特性

松尾文香、西村裕一、中村将行、古賀啓太、住吉美保、松島綾美、野瀬　健、下東美樹、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
エンドモルフィン-2の連続するPhe残基のフェニル基ハロゲン化によるμオピオイド受容体に対する相互作用の変化

西尾華奈子、西村裕一、巣山慶太郎、阿部由則、松島綾美、野瀬　健、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
神経ペプチド・サブスタンスPに存在するフェニルアラニン連続残基のハロゲン化が特異的受容体結合に与える影響の解析

中村　諒、西村裕一、巣山慶太郎、野瀬　健、下東康幸

第48回ペプチド討論会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：札幌コンベンションセンター、札幌市 Country：Japan
4-ヨードフェノールとヒト核内受容体ERRγとの強いハロゲン結合

松島綾美、劉　暁輝、野瀬　健、角田佳充、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
疼痛ノシセプチン受容体の純アンタゴニストのトリチウム標識標準化合物の受容体結合特性の解析

稲嶺翔吾、西村裕一、李　京蘭、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
ノシセプチン疼痛受容体における膜貫通ドメインα-ヘリックスの総Ala-スキャニング

西村裕一、李　京蘭、磯崎　要、阿部由則、稲嶺翔吾、松島綾美、野瀬　健、Tomasso Costa、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
オピオイド受容体サブタイプすべてに保存された受容体活性化に必須な第2細胞内ループのヒスチジン残基

阿部由則、松尾崇史、西村裕一、野瀬　健、Tommaso Costa、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
エストロゲン関連受容体γ型・ERRγへのビスフェノールAの結合における受容体の必須構造要因

劉　暁輝、松島綾美、中村将行、野瀬　健、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
ヒト核内受容体RORγの自発活性を抑制するインバースアゴニスト活性を示すビスフェノールA誘導体の同定

錦織充広、野瀬　健、下東康幸

第84回日本生化学会大会 2011.9

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Event date： 2011.9

Presentation type：Oral presentation (general)

Venue：国立京都国際会館（京都市） Country：Japan
SPR分子間相互作用測定によるヒト・オーファン核内受容体LRH-1の低分子リガンドの探索

佐々木彩也香、劉暁輝、松島綾美、野瀬健、下東康幸

第48回化学関連支部合同九州大会 2011.7

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Event date： 2011.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
µ-オピオイド受容体内在性リガンド・エンドモルフィン-2のC末端に連続するPhe残基の重要性

西尾華奈子、巣山慶太郎、西村裕一、松島綾美、野瀬　健、下東康幸

第48回化学関連支部合同九州大会 2011.7

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Event date： 2011.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
ヒト・レチノイン酸受容体（RAR）に結合する化学物質の探索

劉　暁輝、縄司　奨、松島綾美、野瀬　健、下東康幸

平成23年度日本生化学会九州支部例会 2011.5

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Event date： 2011.5

Presentation type：Oral presentation (general)

Venue：久留米大学医学部・筑水会館（福岡） Country：Japan
疼痛受容体アンタゴニストのトリチウム標識標準化合物の開発およびその結合特性の解析

稲嶺翔吾、西村裕一、李　京蘭、松島綾美、野瀬　健、Tommaso Costa、下東康幸

平成23年度日本生化学会九州支部例会 2011.5

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Event date： 2011.5

Presentation type：Oral presentation (general)

Venue：久留米大学医学部・筑水会館（福岡） Country：Japan
疼痛ORL1受容体膜貫通ドメインの構造機能相関解析

西村裕一、李　京蘭、磯崎　要、阿部由則、稲嶺翔吾、松島綾美、野瀬　健、Tommaso Costa、下東康幸

平成23年度日本生化学会九州支部例会 2011.5

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Event date： 2011.5

Presentation type：Oral presentation (general)

Venue：久留米大学医学部・筑水会館（福岡） Country：Japan
オピオイド受容体第2細胞内ループに保存された受容体活性化に必須なHis残基の同定

阿部由則、松尾崇史、西村裕一、野瀬　健、下東康幸

平成23年度日本生化学会九州支部例会 2011.5

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Event date： 2011.5

Presentation type：Oral presentation (general)

Venue：久留米大学医学部・筑水会館（福岡） Country：Japan
レチノイドＸ受容体（３）：γ型（RXRγ）に結合する化学物質の構造要因

西垣内誠、劉暁輝、酒井大樹、巣山慶太郎、松島綾美、野瀬健、下東康幸

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ERαアゴニストおよびERβアンタゴニストとして働く化学物質の構造要因

下東康幸、劉　暁輝、松島綾美、野瀬　健、下東美樹

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
レチノイド関連オーファン受容体RORsに特異的に結合するジ-sec-ブチルビスフェノールＡ

錦織充広、野瀬　健、下東康幸

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
レチノイドX受容体(2):β型(RXRβ)に結合する化学物質の構造要因

巣山慶太郎、劉　暁輝、酒井大樹、西垣内　誠、松島綾美、野瀬　健、下東康幸

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
レチノイド受容体に結合する化学物質の構造要因

巣山慶太郎、劉　暁輝、酒井大樹、西垣内　誠、錦織充広、縄司　奨、松島綾美、野瀬　健、下東康幸

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
ERαにおける結合性リガンドの芳香環認識構造要因・Leu-387側鎖の重要性

野瀬　健、村田聡史、下東康幸

環境ホルモン学会　第13回研究発表会 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館（東京） Country：Japan
Exploration of the binding site of ORL1 nociceptin receptor antagonist International conference

Shogo Inamine, Jinglan Li, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi

5th International Peptide Symposium 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Country：Japan
Structure-activity studies on nociceptin and its receptor ORL1 Invited International conference

Yasuyuki Shimohigashi, Hirokazu Nishimura, Jinglan Li, Nobuko Inokuchi, Sayaka Koikawa, Takeru Nose, Ayami Matsushima, Tommaso Costa

5th International Peptide Symposium 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Country：Japan
A Trp residue of opioid recetor TM5 is present at the cell membrane interface as a molecular anchor for full activation International conference

Hirokazu Nishimura, Jinglan Li, Nobuko Inokuchi, Sayaka Koikawa, Takeru Nose, Ayami Matsushima, Tommaso Costa, Yasuyuki Shimohigashi

5th International Peptide Symposium 2010.12

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Event date： 2010.12

Presentation type：Oral presentation (general)

Country：Japan
核内受容体・レチノイン受容体α型に対する化学物質の結合試験系の構築

縄司　奨、野瀬　健、酒井　大樹、錦織　充広、下東　康幸

第47回化学関連支部合同九州大会 2010.7

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Event date： 2010.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
疼痛ペプチド・ノシセプチンの純アンタゴニストMeSAC-RYYRIK-NH2の受容体結合部位

稲嶺翔吾、李　京蘭、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第47回化学関連支部合同九州大会 2010.7

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Event date： 2010.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場（北九州市） Country：Japan
オピオイド受容体δ、μ、κに共通するTM5におけるTrp残基の役割

西村裕一、李　京蘭、井口暢子、肥川紗矢香、松島綾美、野瀬　健、Tommaso Costa、下東康幸

平成22年度日本生化学会九州支部例会 2010.5

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Event date： 2010.5

Presentation type：Oral presentation (general)

Venue：鹿児島大学郡元キャンパス Country：Japan
ORL1ノシセプチン受容体のAla-スキャン変異受容体を用いた構造活性相関解析

李　京蘭、磯崎　要、松島綾美、野瀬　健、Tomasso Costa、下東康幸

平成22年度日本生化学会九州支部例会 2010.5

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Event date： 2010.5

Presentation type：Oral presentation (general)

Venue：鹿児島大学郡元キャンパス Country：Japan
女性ホルモン受容体の化学物質結合性予測計算における受容体構造の役割

野瀬　健、下東康幸

第1２回環境ホルモン学会研究発表会 2009.12

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Event date： 2009.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館、東京都 Country：Japan
核内受容体Rev-erbsに対するヘム結合性の分光学的測定

永田裕介、野瀬　健、錦織充広、下東康幸

第1２回環境ホルモン学会研究発表会 2009.12

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Event date： 2009.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館、東京都 Country：Japan
500化学物質のレチノイド関連オーファン受容体β型（RORβ）への結合性

錦織充広、野瀬　健、下東康幸

第1２回環境ホルモン学会研究発表会 2009.12

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Event date： 2009.12

Presentation type：Oral presentation (general)

Venue：東京大学山上会館、東京都 Country：Japan
ORL1 receptor Asp206 and Try207 as the binding sites of nociceptin superagonist (Arg/Lys/Trp)14 and (Arg/Lys)15 residues International conference

Nishimura Hirokazu, Li Jinglan, Isozaki Kaname, Okada Kazushi, Matsushima Ayami, Nose Takeru, Costa Tommaso, Shimohigashi Yasuyuki

3rd International peptide symposium 2009.11

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Event date： 2009.11

Presentation type：Oral presentation (general)

Country：Korea, Republic of
Intrinsic structural essentials in binding and activation of ORL1 nociceptin receptor International conference

Li Jinglan, Isozaki Kaname, Nose Takeru, Costa Tommaso, Shimohigashi Yasuyuki

3rd International peptide symposium 2009.11

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Event date： 2009.11

Presentation type：Oral presentation (general)

Country：Korea, Republic of
エストロゲン受容体結合性化学物質のアゴニスト／アンタゴニスト差ドッキング計算法による探索

野瀬　健、徳永隆俊、下東康幸

第46回ペプチド討論会 2009.11

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Event date： 2009.11

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
オピオイド受容体活性化における細胞膜表面Trp残基の役割

西村裕一、李　京蘭、井口暢子、肥川紗矢香、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第46回ペプチド討論会 2009.11

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Event date： 2009.11

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
ノシセプチン変異受容体による構造機能相関解析

李　京蘭、磯崎　要、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第46回ペプチド討論会 2009.11

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Event date： 2009.11

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
μオピオイド受容体における「膜アンカー」の構造要因

西村裕一、李　京蘭、井口暢子、肥川紗矢香、松島綾美、野瀬　健、Tommaso Costa、下東康幸

第46回化学関連支部合同九州大会 2009.7

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Event date： 2009.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
The effects of Trp-substitutions in superagonist [(Arg, Lys)]nociceptins on ORL1 receptor binding and activation International conference

Hirokazu Nishimura, Jinglan Li, Kaname Isozaki, Kazushi Okada, Ayami Matsushima, Takeru Nose, Tommaso Costa, and Yasuyuki Shimohigashi

2009.5

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Event date： 2009.5

Presentation type：Oral presentation (general)

Country：Korea, Republic of
Screening of Endocrine Disruptor for Retinoid-related Orphan Receptor β (RORβ) by the Competitive Receptor Binding Assay International conference

第19回日韓ジョイントセミナー 2009.5

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Event date： 2009.5

Presentation type：Oral presentation (general)

Venue：韓国　釜山市　BEXCO Country：Korea, Republic of
アゴニスト/アンタゴニストの差ドッキング計算による女性ホルモン受容体に対する化学物質結合性のスクリーニング

野瀬　健、下東康幸

平成21年度日本生化学会九州支部例会 2009.5

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Event date： 2009.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
ORL1受容体新規スーパーアゴニスト・Trp含有ノシセプチンの構造活性相関

西村裕一、李　京蘭、磯崎　要、岡田一志、松島綾美、野瀬　健、Tommaso Costa、下東康幸

平成21年度日本生化学会九州支部例会 2009.5

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Event date： 2009.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
複数の鋳型構造を用いるドッキング計算による化学物質の核内受容体結合性解析

野瀬　健、錦織充広、下東康幸

第11回環境ホルモン学会研究発表会 2008.12

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Event date： 2008.12

Presentation type：Oral presentation (general)

Venue：星陵会館および東京ビッグサイト、東京都 Country：Japan
プリオンタンパク質の分子間相互作用を阻害するペプチドの分子機構解析

古賀啓太、野瀬　健、堀内雄史、下東康幸

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会　(BMB2008) 2008.12

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Event date： 2008.12

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
ドッキング計算を用いた探索法により見い出された4-(1-アダマンチル)フェノールのエストロゲン受容体α型への高親和性結合

野瀬　健、徳永隆俊、下東康幸

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会　(BMB2008) 2008.12

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Event date： 2008.12

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
ノシセプチン受容体ORL1の膜貫通領域におけるリガンド結合および受容体活性化における独立した構造要因

李　京蘭、磯崎　要、野瀬　健、Tomasso Costa、下東康幸

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会　(BMB2008) 2008.12

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Event date： 2008.12

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
オピオイド受容体の第2細胞内ループおよび第6膜貫通ドメインに高く保存されるヒスチジン残基のδ-受容体における重要性

松尾崇史、磯崎要、李京蘭、阿部由則、野瀬健、下東康幸

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会　(BMB2008) 2008.12

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Event date： 2008.12

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
ORL1受容体スーパーアゴニスト・ノシセプチン誘導体Trp置換の影響

西村裕一、李　京蘭、磯崎　要、岡田一志、野瀬　健、Tommaso Costa、下東康幸

第45回ペプチド討論会 2008.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：タワーホール船堀、東京都 Country：Japan
プリオンタンパク質の分子間相互作用を阻害するN端テトラリピート結合αヘリックスペプチドの分子機構

古賀啓太、野瀬　健、堀内雄史、下東康幸

第45回ペプチド討論会 2008.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：タワーホール船堀、東京都 Country：Japan
ORL1受容体の活性化に必須な膜貫通領域アミノ酸残基

李　京蘭、磯崎　要、野瀬　健、Tommaso Costa、下東康幸

第45回ペプチド討論会 2008.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：タワーホール船堀、東京都 Country：Japan
δ-オピオイド受容体において必須であるヒスチジン

松尾崇史、阿部由則、李京蘭、磯崎要、野瀬健、下東康幸

第45回ペプチド討論会 2008.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：タワーホール船堀、東京都 Country：Japan
核内受容体RORβのリガンド結合特性の解析および新規リガンド発見へのアプローチ

錦織充広、野瀬健、下東康幸

第82回日本生化学会大会 2009.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
ドッキング計算を用いたエストロゲン受容体α型に対する化学物質結合性評価法におけるリガンド結合ポケット構造の重要性

野瀬健、下東康幸

第82回日本生化学会大会 2009.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
ノシセプチンスーパーアゴニストの受容体結合部位

李　京蘭、西村裕一、岡田一志、磯崎　要、野瀬　健、Tomasso Costa、下東康幸

第82回日本生化学会大会 2009.10

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Event date： 2008.10

Presentation type：Oral presentation (general)

Venue：神戸ポートアイランド、神戸市 Country：Japan
Prion protein structural distinctiveness characterized by octapeptide tandem repeat International conference

Yuji Horiuchi, Eriko Hattori, Satoru Yokotani, Ayami Matsushima, Takeru Nose, and Yasuyuki Shimohigashi

17th Meeting of Methods in Protein Structure Analysis (MPSA2008) 2008.8

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Event date： 2008.8

Presentation type：Oral presentation (general)

Country：Japan
オピオイド受容体グループに高く保存されるヒスチジン残基のδ−サブタイプにおける機能解析

松尾崇史、磯崎要、李京蘭、野瀬健、下東康幸

第45回化学関連支部合同九州大会 2008.7

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Event date： 2008.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
エストロゲン受容体α型のリガンド認識におけるLeu387を介した分子間相互作用の解析

村田聡史、野瀬健、劉暁輝、錦織充広、徳永隆俊、下東康幸

第45回化学関連支部合同九州大会 2008.7

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Event date： 2008.7

Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
レチノイド関連オーファン受容体 (ROR) のコンホメーション変化認識抗体

錦織充広、野瀬　健、劉　暁輝、徳永隆俊、下東康幸

平成20年度日本生化学会九州支部例会 2008.5

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Event date： 2008.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
ORL1受容体の膜貫通領域に対する構造活性相関解析

李　京蘭、磯崎　要、阿部由則、松尾崇史、野瀬　健、Tommaso Costa、下東康幸

平成20年度日本生化学会九州支部例会 2008.5

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Event date： 2008.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
オピオイド受容体グループに保存されるヒスチジン残基のδ-サブタイプにおける機能解析

松尾崇史、磯崎要、李京蘭、野瀬健、下東康幸

平成20年度日本生化学会九州支部例会 2008.5

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Event date： 2008.5

Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
フラボンおよびイソフラボン類化合物によるショウジョウバエ・エストロゲン関連受容体の転写活性化

○劉　暁輝、松島綾美、徳永隆俊、野瀬　健、冨永佳也、下東美樹、下東康幸

平成17年度日本生化学会九州支部例会 2005.5

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
アメフラシ由来神経ペプチドNdWFamideの生理活性コンホメーションにおけるNH/π 相互作用の形成

横谷　聡、松島綾美、野瀬　健、森下文浩、下東康幸

平成17年度日本生化学会九州支部例会 2005.5

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
ファージディスプレイによる核内受容体コンホメーション変化センシングモノクローナル抗体の作製

岡田浩幸、白須直人、徳永隆俊、野瀬　健、下東康幸

平成17年度日本生化学会九州支部例会 2005.5

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
オピオイド受容体タンパク質のシステイン媒介アフィニティラベリングによる持続性活性化

磯崎　要、肥川紗矢香、野瀬　健、Tommaso Costa、下東康幸

第5回蛋白質化学会年会 2005.6

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Venue：福岡市 Country：Japan
生体分子認識におけるπ系水素結合

野瀬　健

化学・材料COEに向けての研究セミナー 2005.7

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Venue：東京都・星薬科大 Country：Japan
ファージディスプレイ法による核内受容体認識モノクローナル抗体の調製

岡田浩幸、白須直人、徳永隆俊、野瀬　健、下東康幸

平成17年度化学関連支部合同九州大会 2005.7

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Venue：北九州市 Country：Japan
Simultaneous Evaluation of Binding and Hormonal Activities of Human Glucocorticoid Receptor by the Sensing Assay for Receptor Conformation Change International conference

11th Asian Chemical Congree 2005.8

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Country：Korea, Republic of
Site-directed Cysteine-mediated Affinity Labeling of the delta Opioid Receptors International conference

Kaname Isozaki, Jun-ichi Funama, Sayaka Koikawa, Hidehiko Fukahori, Kazushi Okada, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi

11th Asian Chemical Congree 2005.8

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Country：Korea, Republic of
糖質コルチコイド受容体に対する内分泌撹乱作用性のコンホメーション変化センシング抗体法による評価

岡田浩幸、徳永隆俊、白須直人、松島綾美、野瀬　健、下東康幸

環境ホルモン学会第8回研究発表会 2005.9

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Venue：東京都 Country：Japan
高感度センシング抗体によるエストロゲン受容体—化学物質系のリスク評価

徳永隆俊、渋谷あゆみ、浅井大輔、野瀬　健、中井　誠、矢可部芳州、毛利資郎、小泉　修、下東康幸

環境ホルモン学会第8回研究発表会 2005.9

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Venue：東京都 Country：Japan
受容体コンホメーション変化センシング抗体法による受容体結合能およびホルモン活性の同時評価：黄体ホルモン・プロゲステロン受容体に対する化学物質の応答解析

下東康幸、徳永隆俊、岡田浩幸、野瀬　健、中井　誠、矢可部芳州

環境ホルモン学会第8回研究発表会 2005.9

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Venue：東京都 Country：Japan
変異受容体を用いたアフィニティラベリングによるδオピオイド受容体リガンド結合部位に存在するシステイン残基の同定

磯崎　要、船間純一、肥川紗矢香、深堀英彦、野瀬　健、Tommaso Costa、下東康幸

平成17年度日本生化学会 2005.10

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Venue：神戸市 Country：Japan
Flavone and isoflavone phytoestrogens as agonist of estrogen-related receptor in the fruit fly Drosophila

2005.10

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Country：Japan
αヘリックス認識抗体による糖質コルチコイド受容体におけるリガンド依存的コンホメーション変化の識別

岡田浩幸、白須直人、徳永隆俊、松島綾美、野瀬　健、下東康幸

平成17年度日本生化学会 2005.10

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Presentation type：Symposium, workshop panel (public)

Venue：神戸市 Country：Japan
δオピオイド受容体のアフィニティラベリングによる持続的受容体活性化

磯崎　要、船間純一、野瀬　健、Tommaso Costa、下東康幸

ペプチド討論会 2005.10

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Presentation type：Oral presentation (general)

Venue：大阪府吹田市 Country：Japan
ファージディスプレイ法による核内受容体コンホメーション変化センシング抗体調製のためのα-ヘリックスペプチド

岡田浩幸、徳永隆俊、白須直人、松島綾美、野瀬　健、下東康幸

ペプチド討論会 2005.10

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Venue：大阪府吹田市 Country：Japan
コンホメーション変化センシング抗体による糖質コルチコイド受容体における化学物質の内分泌撹乱作用性評価

岡田浩幸、徳永隆俊、白須直人、松島綾美、野瀬　健、下東康幸

第52回日本臨床検査医学会・第45回日本臨床化学会合同大会 2005.11

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Venue：福岡市 Country：Japan
蛍光トレーサーを用いたB/F分離有・無両系のステロイドホルモン受容体結合試験の確立

徳永隆俊・浅井大輔・横谷　聡・野瀬　健・下東康幸

第52回日本臨床検査医学会・第45回日本臨床化学会合同大会 2005.11

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Venue：福岡市 Country：Japan
The role of aromatic amino acid residues present in the fifth transmembrane domain in activation of ORL1 nociceptin receptor

Sayaka Koikawa, Kaname Isozaki, Kazushi Okada, Jyun-ichi Funama, Takeru Nose, Tommaso Costa, and Yasuyuki Shimohigashi

2006.6

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Country：Japan
The role of aromatic amino acid residues present in the fifth transmembrane domain in activation of ORL1 nociceptin receptor

Sayaka Koikawa, Kaname Isozaki, Kazushi Okada, Jyun-ichi Funama, Takeru Nose, Tommaso Costa, and Yasuyuki Shimohigashi

2006.6

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Country：Japan
変異受容体によるORL1受容体タンパク質のリガンド結合および受容体活性化機構の解析

磯崎要、岡田一志、肥川紗矢香、野瀬健、Tommaso Costa、下東康幸

第6回日本蛋白質科学会年会 2006.7

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Venue：京都市 Country：Japan
ORL1受容体活性化における細胞膜界面上Trp208の役割

肥川紗矢香、磯崎要、岡田一志、野瀬健、Tommaso Costa、下東康幸

平成18年度日本生化学会九州支部例会 2006.7

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
Ac-RYYRIK-NH2を母体にした新規ノシセプチンアンタゴニストの設計

李　京蘭、磯崎　要、野瀬　健、Tommaso Costa,下東　康幸

平成18年度日本生化学会九州支部例会 2006.7

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
鉱質コルチコイド受容体を介した内分泌撹乱作用性評価のためのコンホメーション変化センシング抗体の作製

金森史花、岡田浩幸、野瀬　健、下東康幸

平成18年度化学関連支部合同九州大会 2006.7

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Venue：北九州市 Country：Japan
Acyl-RYYRIK-NH2　N末端アシルーアルキル基鎖長と完全アンタゴニスト活性との相関

李　京蘭、磯崎　要、野瀬　健、Tommaso Costa、下東康幸

平成18年度化学関連支部合同九州大会 2006.7

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Venue：北九州市 Country：Japan
エストロゲン関連受容体γ型（ERRγ）のコンホメーション変化センシング抗体アッセイ：ビスフェノールAの受容体応答活性

徳永隆俊・劉　暁輝・岡田浩幸・松島綾美・野瀬　健・下東康幸

環境ホルモン学会第9回研究発表会 2006.11

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Venue：東京都・星薬科大 Country：Japan
内分泌撹乱物質ビスフェノールAのエストロゲン関連受容体γ型(ERRγ）へのドッキングモデリング

野瀬　健・下東康幸

環境ホルモン学会第9回研究発表会 2006.11

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Venue：東京都・星薬科大 Country：Japan
Conformation Change of α-Helix Peptide for Sensing of Deactivation of Nuclear Receptor: Immunoassay Using Polyclonal Antibody Specific for the C-terminal α-Helix 12 of Estrogen-related Receptor γ (ERRγ) International conference

2006.11

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Venue：横浜 Country：Japan
Residual Roles of Hydrophobic Amino Acids in the Fifth Transmembrane Domain of ORL1 Receptor in Its Activation International conference

Kaname Isozaki, Kazushi Okada, Sayaka Koikawa, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi

JPS2006-PEM4 2006.11

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Presentation type：Oral presentation (general)

Country：Japan
Synthesis of Pure Antagonist of ORL1 Nociceptin Receptor International conference

Jinglan Li, Kaname isozaki, Takeru Nose,Tommaso Costa, Yasuyuki Shimohigashi

JPS2006-PEM4 2006.11

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Country：Japan
エストロゲン関連受容体γ型（ERRγ）とビスフェノールＡの結合構造解析

野瀬健、下東康幸

平成19年度日本生化学会九州支部例会 2007.5

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Venue：宮崎市 Country：Japan
コンホメーション変化センシング抗体アッセイ法によるエストロゲン関連受容体γ型（ERRγ）への化学物質の影響評価

徳永隆俊、劉　暁輝、岡田浩幸、松島綾美、野瀬　健、下東康幸

平成19年度日本生化学会九州支部例会 2007.5

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Presentation type：Oral presentation (general)

Venue：宮崎市 Country：Japan
μオピオイド受容体に対するエンケファリンダイマーリガンドを用いた構造活性相関解析

磯崎　要、井口暢子、野瀬健、津田裕子、岡田芳男、Tommaso Costa、下東康幸

平成19年度日本生化学会九州支部例会 2007.5

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Presentation type：Oral presentation (general)

Venue：宮崎市 Country：Japan
アフィニティラベリング法によるδオピオイド受容体の機能発現機構の解析

磯崎　要、野瀬健、Tommaso Costa、下東康幸

日本ケミカルバイオロジー研究会　第2回年会 2007.5

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Presentation type：Oral presentation (general)

Venue：京都大学百周年時計台記念館百周年記念ホール、京都市 Country：Japan
レチノイド関連オーファン核内受容体RORを介した内分泌撹乱作用評価試験系の構築

錦織充広、徳永隆俊、松島綾美、野瀬　健、下東康幸

第44回化学関連支部合同九州大会 2007.7

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Presentation type：Oral presentation (general)

Venue：北九州国際会議場、北九州市 Country：Japan
ノシセプチン・ORL1受容体の第6膜貫通領域アミノ酸残基による受容体活性化の分子機構

磯崎要、李　京蘭、野瀬健、Tommaso Costa、下東康幸

第44回ペプチド討論会 2007.11

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Presentation type：Oral presentation (general)

Venue：富山国際会議場、富山市 Country：Japan
イボニシ生理活性ペプチドTEP-1およびTEP-2の構造解析

堀内雄史、野瀬　健、阿部義人、下東康幸、森下文浩

第44回ペプチド討論会 2007.11

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Presentation type：Oral presentation (general)

Venue：富山国際会議場、富山市 Country：Japan
ORL1受容体のアンタゴニストとしてのAc-RYYRIK-NH2のN末端基の最適化

李京蘭、磯崎要、野瀬健、Tommaso Costa、下東康幸

第44回ペプチド討論会 2007.11

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Presentation type：Oral presentation (general)

Venue：富山国際会議場、富山市 Country：Japan
レチノイド関連オーファン受容体ファミリーのコンホメーション変化センシング抗体

錦織充広、野瀬健、劉暁輝、徳永隆俊、下東康幸

第44回ペプチド討論会 2007.11

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Presentation type：Oral presentation (general)

Venue：富山国際会議場、富山市 Country：Japan
ORL1受容体の第６膜貫通領域における受容体活性化の構造要因

磯崎要，李　京蘭，野瀬　健，Tommaso Costa，下東康幸

第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 2007.12

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Presentation type：Oral presentation (general)

Venue：パシフィコ横浜、横浜市 Country：Japan
NMR analysis of His-Trp pi-pi intermolecular interaction formed between the prion protein N-terminal octarepeats

2007.12

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Presentation type：Oral presentation (general)

Country：Japan
Synthesis of novel antagonist of ORL1 receptor

2007.12

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Presentation type：Oral presentation (general)

Country：Japan
女性ホルモン受容体ERαに対するアルキルフェノール類の結合性の予測

野瀬　健、徳永隆俊、錦織充広、下東康幸

第10回環境ホルモン学会研究発表会 2007.12

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Presentation type：Oral presentation (general)

Venue：大宮ソニックシティさいたま市 Country：Japan
化学物質の内分泌かく乱作用評価のためのコンホメーション変化センシング抗体アッセイ法：ヒト核内受容体全48種への展開

徳永隆俊、野瀬　健、劉　暁輝、岡田浩幸、岩崎　茜、金森史花、磯野裕章、錦織充広、松島綾美、下東美樹、下東康幸

第10回環境ホルモン学会研究発表会 2007.12

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Presentation type：Oral presentation (general)

Venue：大宮ソニックシティさいたま市 Country：Japan
δ-オピオイド受容体の変異体を用いたアフィニティラベリング

○磯崎　要、肥川紗矢香、深堀英彦、岡田一志、白須直人、本田　健、野瀬　健、Tommaso Costa、下東康幸

平成17年度日本生化学会九州支部例会 2005.5

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
活性化チオール基含有ダイノルフィンA誘導体によるオピオイド受容体のアフィニティーラベリング

白須直人、黒水拓也、中尾秀徳、野瀬　健、下東康幸

第35回化学関連支部合同九州大会 1998.7

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Presentation type：Oral presentation (general)

Venue：九州大学（福岡市） Country：Japan
疼痛ペプチド・ノシセプチンのアミノ酸置換による活性相関

岡田一志、中島理恵、野瀬　健、朱雀鉄城、長久　厚、下東康幸

第35回化学関連支部合同九州大会 1998.7

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Presentation type：Oral presentation (general)

Venue：九州大学（福岡市） Country：Japan
トロンビン受容体を介する血小板凝集阻害ペプチドの分子設計

森田由紀、藤田亜美、野瀬　健、下東康幸

第35回化学関連支部合同九州大会 1998.7

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Presentation type：Oral presentation (general)

Venue：福岡市 Country：Japan
トロンビン受容体リガンドペプチドのアゴニスト・アンタゴニスト構造要因

野瀬　健、藤田亜美、森田由紀、Tommaso Costa、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
ペプチドライブラリーよりのリン脂質分解酵素・ホスホリパーゼA2インヒビター

千綿　剛、森田由紀、宮本浩一郎、中島理恵、野瀬　健、佐々木茂貴、前田　稔、大野素徳、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
トロンビン受容体活性化におけるリガンドPhe-2の相互作用

藤田亜美、野瀬　健、Tommaso Costa、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
セリンプロテアーゼHis-57スタック型インヒビターの構造ー活性相関

山内泰子、池末公一、野瀬　健、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
ノシセプチンによる疼痛受容体ORL1活性化の構造要因

岡田一志、中島理恵、野瀬　健、朱雀鉄城、長久　厚、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
ダイノルフィンA誘導体によるオピオイド受容体のアフィニティーラベリング

白須直人、黒水拓也、中尾秀徳、中馬吉郎、野瀬　健、Tommaso Costa、下東康幸

第35回ペプチド化学討論会 1998.10

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Presentation type：Oral presentation (general)

Venue：佐賀大（佐賀市） Country：Japan
ヒメハブ毒腺トロンビン様酵素2種のcDNAクローニングとその分子進化

弟子丸正伸、野瀬　健、下東康幸、服巻保幸、大野素徳

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
ペプチドライブラリーよりのホスホリパーゼA2阻害剤の検索

千綿　剛、森田由紀、宮本浩一郎、中島理恵、野瀬　健、佐々木重貴、前田　稔、下東康幸

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
トロンビン受容体活性化におけるリガンド—受容体芳香族アミノ酸間のEdge-to Face CH/π相互作用

野瀬　健、藤田亜美、Tommaso Costa、下東康幸

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
トロンビン受容体アンタゴニストの構造—活性相関

野瀬　健、藤田亜美、Tommaso Costa、下東康幸

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
活性化チオール基含有ダイノルフィンA誘導体によるオピオイド受容体のアフィニティーラベリング

白須直人、黒水拓也、中尾秀徳、中馬吉郎、野瀬　健、下東康幸

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
疼痛ペプチド・ノシセプチンの2、3位Gly-Gly残基のD-アミノ酸置換による受容体結合性の変化

岡田一志、中島理恵、野瀬　健、下東康幸、朱雀鉄城、長久　厚

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
CH/π相互作用を骨格にもつセリンプロテアーゼ阻害剤の分子設計

山内泰子、池末公一、野瀬　健、下東康幸

第71回日本生化学会 1998.10

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Presentation type：Oral presentation (general)

Venue：名古屋市 Country：Japan
疼痛に関するペプチド・ノシセプチンのスーパーアゴニスト

岡田一志、中島理恵、野瀬　健、下東康幸

日本生化学会九州支部例会 1999.4

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Presentation type：Oral presentation (general)

Venue：久留米大（久留米市） Country：Japan
受容体結合におけるリガンドペプチドPhe-フェニル基の結合様式：オピオイドδ型サブタイプにおける相互作用

白須直人、本田　健、重弘大樹、岡田一志、中馬吉郎、野瀬　健、下東康幸

日本生化学会九州支部例会 1999.4

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Presentation type：Oral presentation (general)

Venue：久留米大（久留米市） Country：Japan
トロンビン受容体における含フッ素フェニルアラニンによるリガンド−受容体相互作用様式の解析

藤田亜美、松島綾美、野瀬　健、栗林　太、下東康幸

日本生化学会九州支部例会 1999.4

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Presentation type：Oral presentation (general)

Venue：久留米大（久留米市） Country：Japan
オピオイドペプチド・デルトルフィンIIおよびエンドモルフィン2の3位フェニルアラニンの受容体相互作用

本田　健、重弘大樹、白須直人、中馬吉郎、藤田亜美、野瀬　健、下東康幸

第72回日本生化学会 1999.10

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Presentation type：Oral presentation (general)

Venue：横浜市 Country：Japan
δ型受容体とリガンドペプチド４位Pheの結合様式

白須直人、本田　健、重弘大樹、岡田一志、中馬吉郎、藤田亜美、野瀬　健、下東康幸

第72回日本生化学会 1999.10

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Presentation type：Oral presentation (general)

Venue：横浜市 Country：Japan
ORL1受容体芳香族性基との相互作用増強による疼痛ペプチド・ノシセプチンの高活性化

岡田一志、中馬吉郎、中島理恵、野瀬　健、下東康幸

第72回日本生化学会 1999.10

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Presentation type：Oral presentation (general)

Venue：横浜市 Country：Japan
Structure-function studies on nociceptin and its receptor ORL1 International conference

Yasuyuki Shimohigashi, Kazushi Okada, Michiaki Kawano, Yoshiro Chuman, Takeru Nose, and Tommaso Costa

The 4th Symposium on Frontiers in Protein Chemistry and Biotechnology 2001.8

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Presentation type：Oral presentation (general)

Country：China
Structural evaluation of receptor/ligand interactions for activation of thrombin receptor International conference

Takeru Nose, Tsugumi Fujita, Tommaso Costa, and Yasuyuki Shimohigashi

The 4th Symposium on Frontiers in Protein Chemistry and Biotechnology 2001.8

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Presentation type：Oral presentation (general)

Country：China
Structure-Function Studies on Nociceptin and Its Receptor ORL1 Invited International conference

Yasuyuki Shimohihashi, Kazushi Okada, Yoshiro Chuman, Takeru Nose, and Tommaso Costa

Annual Conference on Opioid Mimetic Analgesics 2002 2002.3

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Presentation type：Oral presentation (general)

Country：Japan
Differential Receptor Interaction Modes of Aromatic Residues Phe-1 and Phe-4 in Nociceptin International conference

Kazushi Okada, Takeru Nose, Tommaso Costa, and Yasuyuki Shimohigashi

Annual Conference on Opioid Mimetic Analgesics 2002 2002.3

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Country：Japan
Molecular Modeling of Opioid Receptors Affinity-labeled by Enkephalin/Dynorphin via Disulfide Bonding International conference

Takeru Nose, Michiaki Kawano, Naoto Shirasu, and Yasuyuki Shimohigashi

Annual Conference on Opioid Mimetic Analgesics 2002 2002.3

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Country：Japan
Localization Profiles of the Precursor Protein of Circadian Rhythm Pacemaker Hormone PDF in Gryllus Brain

Takeshi Honda, Yoshiro Chuman, Ayami Matsushima, Daisuke Asai, Takeru Nose, Kazuyasu Sakaguchi, Hitoshi Onoue, Yoshiya Tominaga, Yasuyuki Shimohigashi, and Miki Shimohigashi

2002.10

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Country：Japan
Gene and peptide expressions of a circadian neuropeptide PDF in the flies International conference

Ayami Matsushima, Seiji Sato, Yukimasa Takeda, Satoru Yokotani, Daisuke Asai, Takeru Nose, Yasuyuki Shimohigashi Mamiko Ozaki, Yoshiya Tominaga, and Miki Shimohigashi

2003.9

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Country：Japan
Site-directed Affinity labeling of Free Cysteine Residues in d Opioid Receptors by SNpys-containing Enkephalin and Dynorphin Analogs International conference

Kaname Isozaki, Hidehiko Fukahori, Kazushi Okada, Naoto Shirasu, Takeshi Honda, Takeru Nose, Kazuyasu Sakaguchi & Yasuyuki Shimohigashi

International Assembly in Neurobiology (IAN 2004) 2004.3

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Country：Japan
Structure-Activity Studies of the Sea Hare Aplysia Neuropeptide H-Asn-D-Trp-Phe-NH2 and Its Analogues Containing Fluorophenylalannes International conference

Satoru Yokotani, Ayami Matsushima, Takeru Nose, Yasuyuki Shimohigashi, Fumihiro Morishita

International Assembly in Neurobiology (IAN 2004) 2004.3

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Country：Japan
内分泌撹乱化学物質の統括的リスク評価法の開発 Invited

野瀬　健、下東康幸、根津尚史

平成16年度研究助成事業成果報告会 2005.1

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Presentation type：Oral presentation (general)

Venue：東京国際フォーラム Country：Japan
蛍光7-ニトロベンゾ-2-オキサ-1,3-ジアゾール（NBD）誘導体を用いたステロイドホルモン受容体結合試験系の確立

徳永隆俊・浅井大輔・横谷　聡・吉田美由紀・野瀬　健・下東康幸

平成17年度日本生化学会九州支部例会 2005.5

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Venue：福岡市 Country：Japan

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MISC

ペプチド性GPCRリガンドの高効率構造活性相関解析研究

野瀬　健, 下東康幸

遺伝子医学 MOOK, (12), 274-282 (2012). 2012.3

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天然タンパク質から短鎖合成ペプチドへ：エラスチンペプチドの金属捕集剤への応用

巣山慶太郞, 野瀬　健

アグリバイオ 2022.8

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温度依存的に凝集するエラスチンペプチドによる食品基材の開発

野瀬健

浦上財団研究報告書 2015.3

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Language：Japanese
基幹教育セミナーの実施体制について

野瀬健, 飯嶋裕治, 小島健太郎, 佐合紀親, 斎藤新悟, 猿渡悦子, 田中岳, 内田竜也

九州大学基幹教育院 2015.3

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授業紹介　基幹教育セミナー　基幹教育セミナー科目実施班から

野瀬健

基幹教育院ニューズレター　Summer 2014 1 2014.7

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厚生労働科学研究補助金　化学物質リスク研究事業　核内受容体結合能およびホルモン活性同時測定法による化学物質リスク評価　分担研究報告　複数の鋳型を用いたドッキング計算によるリガンド結合性解析

野瀬　健

2010.3

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厚生労働科学研究補助金　化学物質リスク研究事業　核内受容体結合能およびホルモン活性同時測定法による化学物質リスク評価　分担研究報告　核内受容体RORβおよびRev-erbにおける結合競争試験

野瀬　健

2009.3

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厚生労働科学研究補助金　化学物質リスク研究事業　核内受容体結合能およびホルモン活性同時測定法による化学物質リスク評価　分担研究報告　エピトープ解析、ポリクローナル抗体の設計作製および試験

野瀬　健

2008.3

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プリオン論争に終止符？

野瀬　健

化学、60(1), 59-60 (2005). 2005.1

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ハイスループット化を指向した内分泌かく乱物質の検出法

野瀬　健

化学、58(8), 59-60 (2003). 2003.8

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ノシセプチンの構造活性相関

野瀬　健, 下東康幸

医学のあゆみ 1998.11

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Industrial property rights

Patent	Number of applications: 4	Number of registrations: 4
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Professional Memberships

日本内分泌撹乱化学物質学会
日本ペプチド学会
日本生化学会
日本化学会
American Chemical Society
環境ホルモン学会

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日本生化学会

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日本化学会

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日本内分泌撹乱化学物質学会

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日本ペプチド学会

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Committee Memberships

Councilor Domestic

2018.6 - 2023.5
日本生化学会代議員 Domestic

2017.11 - 2019.11
Councilor Domestic

2016.5 - 2023.5
Organizer Domestic

2009.3 - 2010.2
Organizer Domestic

2005.10 - 2006.9

Academic Activities

Screening of academic papers

Role(s)： Peer review

2023

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：4

Proceedings of domestic conference Number of peer-reviewed papers：2
Screening of academic papers

Role(s)： Peer review

2022

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3
Screening of academic papers

Role(s)： Peer review

2021

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：3

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：2
Screening of academic papers

Role(s)： Peer review

2020

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：2

Number of peer-reviewed articles in Japanese journals：1

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：2
Screening of academic papers

Role(s)： Peer review

2019

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：2

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：0
nternational Program Committee and Local Organizing Committee International contribution

10th International Peptide Symposium （ ROHM Theatre Kyoto and Miyakomesse (Kyoto, Japan) Japan ） 2018.12 - 2019.12

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Type：Competition, symposium, etc.

Number of participants：800
Screening of academic papers

Role(s)： Peer review

2018

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：5

Number of peer-reviewed articles in Japanese journals：0

Proceedings of International Conference Number of peer-reviewed papers：0

Proceedings of domestic conference Number of peer-reviewed papers：0
Screening of academic papers

Role(s)： Peer review

2017

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：2
座長（Chairmanship）

平成28年度日本生化学会九州支部例会（鹿児島大学、福岡市） 2016.5

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Type：Competition, symposium, etc.
Screening of academic papers

Role(s)： Peer review

2016

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Type：Peer review

Number of peer-reviewed articles in foreign language journals：1
世話人

第13回泉屋コロキウム（原鶴温泉咸生閣） 2013.9

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Type：Competition, symposium, etc.

Number of participants：67
座長（Chairmanship）

第49回ペプチド討論会（かごしま県民交流センター、鹿児島市） 2012.11

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Type：Competition, symposium, etc.
座長（Chairmanship）

平成24年度日本生化学会九州支部例会（福岡大学、福岡市） 2012.5

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Type：Competition, symposium, etc.
座長（Chairmanship）

第48回ペプチド討論会（札幌コンベンションセンター、札幌市） 2011.9

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Type：Competition, symposium, etc.
座長（Chairmanship）

第46回ペプチド討論会（北九州市） 2009.11

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Type：Competition, symposium, etc.
実行委員

第46回日本ペプチド討論会（北九州市国際会議場　北九州市） 2009.11

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Type：Competition, symposium, etc.

Number of participants：400
実行委員

第４６回化学関連支部合同大会（北九州市国際会議場　北九州市） 2009.7

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Type：Competition, symposium, etc.

Number of participants：500
実行委員

第２０回産学ユースフォーラム（北九州市国際会議場　北九州市） 2009.7

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Type：Competition, symposium, etc.

Number of participants：100
世話人 International contribution

2009.5

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Type：Competition, symposium, etc.

Number of participants：120
座長（Chairmanship）

平成21年度日本生化学会九州支部例会（福岡市） 2009.5

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Type：Competition, symposium, etc.
実行委員

第12回ペプチドフォーラム－ペプチドサイエンスの最前線－（九州工業大学若松キャンパス　北九州市） 2009.1

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Type：Competition, symposium, etc.

Number of participants：40
座長（Chairmanship）

第45回ペプチド討論会（東京都） 2008.10

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Type：Competition, symposium, etc.
座長（Chairmanship）

平成20年度日本生化学会九州支部例会（福岡市） 2008.5

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Type：Competition, symposium, etc.
世話役

第７回泉屋コロキウム（九州地区国立大学九重共同研修所） 2007.8

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Type：Competition, symposium, etc.

Number of participants：61
座長（Chairmanship）

平成19年度日本生化学会九州支部例会（宮崎市） 2007.5

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Type：Competition, symposium, etc.
幹事

平成18年度日本生化学会九州支部シンポジウム（福岡市（九州大学箱崎キャンパス）） 2006.5

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Type：Competition, symposium, etc.

Number of participants：75
幹事

平成18年度日本生化学会九州支部例会（福岡市（九州大学箱崎キャンパス）） 2006.5

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Type：Competition, symposium, etc.

Number of participants：150
Secretary-General International contribution

First Asia-Pacific International Peptide Symposium （ Fukuoka Japan ） 2004.11 - 2005.4

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Type：Competition, symposium, etc.

Number of participants：600
座長（Chairmanship）

平成15年度日本生化学会九州支部例会（熊本市） 2004.5

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Type：Competition, symposium, etc.

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Research Projects

環境水中の有害化学物質除去に資する環境調和型温度応答性ペプチド素材の設計と応用

Grant number：24K03120 2024.4 - 2028.3

科学研究費助成事業基盤研究(B)

野瀬健, 友原啓介, 前田衣織, 巣山慶太郎

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Grant type：Scientific research funding

本研究では、天然アミノ酸からなる合成ペプチド・短鎖Elastin-like polypeptides（sELP）の温度依存的可逆自己凝集能をもとに、水系から化学物質を吸着・捕集し、相分離により除去する新しい環境適応型短鎖ペプチド性分子素材を開発する。本研究では、１）sELPの温度応答性や凝集特性のアミノ酸配列依存性を解明し、凝集温度の制御を可能とする。２）安価で簡便なsELP調製方法を開発し、sELPの応用可能性を拡大する。これらにより、環境水中の化学物質の吸着（結合）、捕集機能を備えたsELPの開発を目指す。

CiNii Research
天然タンパク質資源の有効活用を目指した機能性マイクロ粒子捕集素材の開発

Grant number：20K20638 2020 - 2023

日本学術振興会科学研究費助成事業挑戦的研究（開拓）

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Authorship：Principal investigator Grant type：Scientific research funding
自己凝集性ペプチドの可逆コアセルベーションによる環境汚染物質吸着システムの開発

Grant number：19H04303 2019 - 2021

日本学術振興会科学研究費助成事業基盤研究(B)

野瀬健, 友原啓介, 巣山慶太郎

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Authorship：Principal investigator Grant type：Scientific research funding

本研究では、生分解性を持ち環境負荷が小さなタンパク質を構成するアミノ酸を原料とする温度依存的可逆自己凝集（コアセルベーション）能を有する合成ペプチドを母体として、化学物質の吸着能を有する素材を開発する。これまでの研究で開発された、低濃度かつ室温付近でコアセルベーションを起こす合成ペプチドを用いて、水中の化学物質を吸着除去可能なバイオ素材、および、それを用いる有害物質の回収システムの試作を行う。

CiNii Research
新世代ビスフェノールのシグナル毒性を増強する核内受容体協働作用機構の解明

Grant number：17H01881 2019

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
天然アミノ酸を用いた低環境負荷型イオン回収ペプチドの開発

Grant number：17K20066 2017 - 2018

日本学術振興会科学研究費助成事業挑戦的研究（萌芽）

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Authorship：Principal investigator Grant type：Scientific research funding
ビスフェノールAの化学修飾が引き起こす核内受容体結合力増強機構の解明

Grant number：15H02827 2015 - 2018

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Principal investigator Grant type：Scientific research funding
自己凝集性ペプチドを基材とした金属イオン回収材の開発

Grant number：26550068 2014 - 2015

科学研究費助成事業挑戦的萌芽研究

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Authorship：Principal investigator Grant type：Scientific research funding
温度依存的に凝集するエラスチンペプチドによる新食品基材の開発

2014

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Grant type：Donation
新世代ビスフェノールの核内受容体を介したシグナル毒性

Grant number：22221005 2010 - 2014

日本学術振興会科学研究費助成事業基盤研究(S)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
受容体アッセイ４種からなるヒト核内受容体４８種すべてに対する化学物質リスク評価スキームの構築

Grant number：003 2008 - 2010

科学研究費助成事業厚生労働科学研究費補助金 (厚生労働省)

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Authorship：Coinvestigator(s) Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
核内受容体ERRγを介したビスフェノールAの低用量効果の解明

Grant number：19201012 2007 - 2009

日本学術振興会科学研究費助成事業基盤研究(A)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
クロロベンゼン環およびブロモベンゼン環が誘起する強力な受容体結合力の解明

Grant number：17681005 2005 - 2007

科学研究費助成事業若手研究(A)

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Authorship：Principal investigator Grant type：Scientific research funding
核内受容体結合能およびホルモン活性同時測定法による化学物質リスク評価

Grant number：17011 2005 - 2007

科学研究費助成事業厚生労働科学研究費補助金 (厚生労働省)

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Authorship：Coinvestigator(s) Grant type：Competitive funding other than Grants-in-Aid for Scientific Research
コンホメーション変化センシング抗体法による環境化学物質の核内受容体のリスク評価

Grant number：16310044 2004 - 2006

日本学術振興会科学研究費助成事業基盤研究(B)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
内分泌撹乱化学物質の統括的リスク評価法の開発

2002 - 2004

産業技術研究助成事業 (経済産業省)

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Authorship：Principal investigator Grant type：Contract research

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Educational Activities

I am engaged in the education of the research guidance concerning the structure-function biochemistry for the graduate of the doctor course, master course and bachelor course. I am also taking charge of the lecture of the biochemistry and the practice of the biochemistry experiment as an education of the undergraduate students.
Teaching classes:
1)KIKAN Education;
Kikan-Education Seminar, Interdisciplinary Collaborative Learning of Social Issues Ｂ, Elementary Inorganic Chemistry
2) Undergraduate School Education;
Biological chemistry III, Biochemistry Experiment (Bachelor Course of Department of Chemistry)
3) Graduate School Education;
Biochemistry lecture III (Masters Course of Department of Chemistry)
4) Education Innovation Initiative;
Responsible for reforming the teaching assistant (TA) system.

Class subject

無機物質化学Ⅱ

2024.6 - 2024.8 Summer quarter
生物化学Ⅲ

2024.4 - 2024.9 First semester
無機物質化学Ⅰ

2024.4 - 2024.6 Spring quarter
Advanced Biological Chemistry ⅢA

2023.12 - 2024.2 Winter quarter
生物化学特論ⅢA

2023.10 - 2023.12 Fall quarter
無機物質化学Ⅱ

2023.6 - 2023.8 Summer quarter
生物化学Ⅲ

2023.4 - 2023.9 First semester
無機物質化学Ⅰ

2023.4 - 2023.6 Spring quarter
無機物質化学Ⅱ

2022.6 - 2022.8 Summer quarter
生物化学Ⅲ

2022.4 - 2022.9 First semester
無機物質化学Ⅰ

2022.4 - 2022.6 Spring quarter
生物化学特論ⅢA

2021.10 - 2021.12 Fall quarter
Advanced Biological Chemistry ⅢA

2021.10 - 2021.12 Fall quarter
無機物質化学Ⅱ

2021.6 - 2021.8 Summer quarter
無機物質化学Ⅱ

2021.6 - 2021.8 Summer quarter
基幹教育セミナー

2021.6 - 2021.8 Summer quarter
生物化学Ⅲ

2021.4 - 2021.9 First semester
無機物質化学Ⅱ

2021.4 - 2021.9 First semester
無機物質化学Ⅰ

2021.4 - 2021.9 First semester
無機物質化学Ⅰ

2021.4 - 2021.9 First semester
無機物質化学Ⅱ

2021.4 - 2021.9 First semester
無機物質化学Ⅰ

2021.4 - 2021.6 Spring quarter
無機物質化学Ⅰ

2021.4 - 2021.6 Spring quarter
課題協学科目

2020.10 - 2021.3 Second semester
無機物質化学

2020.10 - 2021.3 Second semester
基幹教育セミナー

2020.6 - 2020.8 Summer quarter
生物化学Ⅲ

2020.4 - 2020.9 First semester
無機物質化学

2019.10 - 2020.3 Second semester
Advanced Biological Chemistry Ⅲ

2019.10 - 2020.3 Second semester
生物化学特論Ⅲ

2019.10 - 2020.3 Second semester
課題協学科目

2019.10 - 2020.3 Second semester
基幹教育セミナー

2019.6 - 2019.8 Summer quarter
生物化学I

2019.4 - 2019.9 First semester
生物化学Ⅲ

2019.4 - 2019.9 First semester
無機物質化学

2018.10 - 2019.3 Second semester
基幹教育セミナー

2018.6 - 2018.8 Summer quarter
基幹教育セミナー

2018.6 - 2018.8 Summer quarter
生物化学Ⅲ

2018.4 - 2018.9 First semester
生物化学特論Ⅲ

2017.10 - 2018.3 Second semester
Advanced Biological Chemistry Ⅲ

2017.10 - 2018.3 Second semester
無機物質化学

2017.10 - 2018.3 Second semester
課題協学科目

2017.10 - 2018.3 Second semester
基幹教育セミナー

2017.6 - 2017.8 Summer quarter
生物化学Ⅲ

2017.4 - 2017.9 First semester
無機物質化学

2016.10 - 2017.3 Second semester
基幹教育セミナー

2016.4 - 2016.9 First semester
生物化学III

2016.4 - 2016.9 First semester
課題協学科目B

2016.4 - 2016.9 First semester
無機物質化学

2015.10 - 2016.3 Second semester
自然科学総合実験

2015.10 - 2016.3 Second semester
生物化学系特論III

2015.10 - 2016.3 Second semester
基幹教育セミナー

2015.4 - 2015.9 First semester
生物化学III

2015.4 - 2015.9 First semester
課題協学科目B

2015.4 - 2015.9 First semester
リスクサイエンス

2014.10 - 2015.3 Second semester
課題協学科目B

2014.10 - 2015.3 Second semester
無機物質化学

2014.10 - 2015.3 Second semester
生物化学III

2014.4 - 2014.9 First semester
基幹教育セミナー

2014.4 - 2014.9 First semester
課題協学科目B

2014.4 - 2014.9 First semester
身の回りの化学

2014.4 - 2014.9 First semester
生物化学系特論III

2013.10 - 2014.3 Second semester
リスクサイエンス

2013.10 - 2014.3 Second semester
生物化学III

2013.4 - 2013.9 First semester
リスクサイエンス

2012.10 - 2013.3 Second semester
生物化学学生実験

2012.4 - 2012.9 First semester
生物化学III

2012.4 - 2012.9 First semester
生物化学系特論III

2011.10 - 2012.3 Second semester
リスクサイエンス

2011.10 - 2012.3 Second semester
生物化学学生実験

2011.4 - 2011.9 First semester
生物化学III

2011.4 - 2011.9 First semester
リスクサイエンス

2010.10 - 2011.3 Second semester
無機物質化学

2010.10 - 2011.3 Second semester
生物化学学生実験

2010.4 - 2010.9 First semester
生物化学III

2010.4 - 2010.9 First semester
リスクサイエンス

2009.10 - 2010.3 Second semester
最先端化学

2009.10 - 2010.3 Second semester
生物化学系特論III

2009.10 - 2010.3 Second semester
無機物質化学

2009.10 - 2010.3 Second semester
生物化学学生実験

2009.4 - 2009.9 First semester
生物化学III

2009.4 - 2009.9 First semester
無機物質化学

2008.10 - 2009.3 Second semester
リスクサイエンス

2008.10 - 2009.3 Second semester
生物化学学生実験

2008.4 - 2008.9 First semester
生物化学III

2008.4 - 2008.9 First semester
生物化学系特論III

2007.10 - 2008.3 Second semester
リスクサイエンス

2007.10 - 2008.3 Second semester
最先端化学

2007.4 - 2007.9 First semester
生物化学学生実験

2007.4 - 2007.9 First semester
生物化学III

2007.4 - 2007.9 First semester
無機物質化学

2007.4 - 2007.9 First semester
生物化学III

2006.4 - 2006.9 First semester
生物化学学生実験

2006.4 - 2006.9 First semester
生物化学系特論III

2005.10 - 2006.3 Second semester
少人数ゼミナールＢ

2005.10 - 2006.3 Second semester
生物化学III

2005.4 - 2005.9 First semester
生物化学学生実験

2005.4 - 2005.9 First semester
生物化学V

2004.10 - 2005.3 Second semester
化学物質と人間環境

2004.10 - 2005.3 Second semester
基礎有機化学

2004.10 - 2005.3 Second semester
生物化学III

2004.4 - 2004.9 First semester
生物化学学生実験

2004.4 - 2004.9 First semester

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FD Participation

2024.3 Role：Moderator Title：令和５年度春季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.3 Role：Planning Title：大学教職員職能開発 FD「⽣成 AI を大学の教育・学習・業務にどのように組み込むか？ -第一弾生成 AI を使った授業デザイン支援のアイデア-」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.3 Role：Participation Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.9 Role：Participation Title：九州大学ラーニングアナリティクスセンター第2回シンポジウム「生成系AIとラーニングアナリティクスによる新たな教育学習支援の可能性」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.9 Role：Moderator Title：令和５年度夏季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.3 Role：Moderator Title：令和4年度春季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.3 Role：Planning Title：大学教職員職能開発FD「TF（ティーチング・フェロー）経験を通じて大学院生の教育能力を高める」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.3 Role：Planning Title：令和4年度春季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.12 Role：Planning Title：リベラルサイエンス教育開発FD　「環境省『ぐぐるプロジェクト』とのコラボレーションでつくる学際的な授業」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.9 Role：Planning Title：令和4年度夏季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.9 Role：Moderator Title：令和4年度夏季基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Planning Title：令和３年度基幹教育院春季ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Moderator Title：令和3年度　基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Speech Title：大学教職員職能開発FD「TA制度の未来を考える〜九州大学の実践例を参考に〜」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Moderator Title：令和３年度基幹教育院春季ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Planning Title：大学教職員職能開発FD「TA制度の未来を考える〜九州大学の実践例を参考に〜」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.9 Role：Moderator Title：令和３年度基幹教育院夏季 FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.9 Role：Moderator Title：令和３年度基幹教育院夏季 FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.9 Role：Participation Title：JST 次世代研究者挑戦的研究プログラム説明会

Organizer：University-wide
2021.9 Role：Participation Title：JST 次世代研究者挑戦的研究プログラム説明会

Organizer：University-wide
2021.6 Role：Participation Title：理系研究室の運営技術 ― ラボラトリーマネジメントという考え方 ―

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.6 Role：Participation Title：理系研究室の運営技術 ― ラボラトリーマネジメントという考え方 ―

Organizer：Undergraduate school department
2021.3 Role：Planning Title：FD講演会「九州大学オンライン授業のグッドプラクティス〜リアルタイム型授業編〜」

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.3 Role：Planning Title：FD講演会「九州大学オンライン授業のグッドプラクティス〜リアルタイム型授業編〜」

Organizer：University-wide
2021.3 Role：Planning Title：FD講演会「九州大学オンライン授業のグッドプラクティス〜オンライン授業編〜」

Organizer：University-wide
2021.3 Role：Moderator Title：オンライン授業におけるアクティブラーニングの科目の実施状況：アクティブラーニングの今後を考える

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.3 Role：Participation Title：令和２年度　基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.3 Role：Participation Title：令和２年度　基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.3 Role：Moderator Title：オンライン授業におけるアクティブラーニングの科目の実施状況：アクティブラーニングの今後を考える

Organizer：[Undergraduate school/graduate school/graduate faculty]
2020.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2020.3 Role：Participation Title：春期基幹教育院ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2020.2 Role：Participation Title：大学院理系研究室のマネジメント－風通しの良い研究室の構築に向けて－

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.9 Role：Participation Title：令和元年度基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.7 Role：Participation Title：３ポリシーに関する全学FD　～日本学術会議分野別参照基準に基づく理学部物理学科の３ポリシー～

Organizer：University-wide
2019.3 Role：Participation Title：学部・研究科等の枠を超えた学位プログラムについて

Organizer：University-wide
2019.3 Role：Speech Title：平成30年度基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.3 Role：Participation Title：３ポリシー見直し方針に関する全学FD

Organizer：University-wide
2019.2 Role：Speech Title：九州大学におけるTA制度のあり方について ―大学教育の質向上に向けて―

Organizer：University-wide
2018.12 Role：Planning Title：リベラルサイエンス教育開発FD「九州大学におけるデータサイエンス教育研究の取組」

Organizer：University-wide
2018.8 Role：Planning Title：第5回基幹教育シンポジウム「高校・大学教育における科学実験の意義と課題－実験による学びとアクティブラーナーの育成－」

Organizer：University-wide
2018.8 Role：Planning Title：リベラルサイエンス教育開発FD 「これからの教養教育・学際教育を考える～これまでの批判的検討と共に～」

Organizer：University-wide
2018.3 Role：Planning Title：FD・SD講演会「アクティブラーニングにおける学びの多様性～合理的配慮の観点からコミュニケーションが苦手な学生への対応を考える～」

Organizer：University-wide
2018.3 Role：Planning Title：カリキュラム・コーディネーター養成講座「カリキュラムデザイン・ワークショップ～学位プログラムの視点から～」

Organizer：University-wide
2018.3 Role：Moderator Title：FD講演会「理系大学院・学部の教育改革を先進事例に学ぶ」

Organizer：University-wide
2018.2 Role：Participation Title：イノベーション教育セミナー「研究活動における社会性と倫理を学ぶためのSTSステートメント」

Organizer：University-wide
2018.1 Role：Planning Title：FD・SDワークショップ「これからの授業外学習支援を考える ―九州大学附属図書館の活動事例を通して―」

Organizer：University-wide
2017.12 Role：Moderator Title：第5回全学FD「大学生の学習時間はなぜ短いのか」

Organizer：University-wide
2017.12 Role：Speech Title：第4回九州大学基幹教育シンポジウム「新たな教養教育の実践と課題～科目開発の実際とその評価を中心に～」

Organizer：University-wide
2017.10 Role：Planning Title：ライティング支援ワークショップ「ピア・サポートによるライティング支援の現状と課題～対話を通じて今後を展望する～」

Organizer：University-wide
2017.10 Role：Participation Title：物理教育ワークショップ「大学の物理教育におけるアクティブ・ラーニングへの挑戦」

Organizer：University-wide
2017.9 Role：Participation Title：九州大学アクティブラーニング教室「The ATLAS initiative：STEM教育におけるアクティブラーニングの大量採用を目指して」

Organizer：University-wide
2017.9 Role：Planning Title：PBLセミナー「PBL教育体制の構築と授業展開 ―三重大学の例をふまえて―」

Organizer：University-wide
2017.9 Role：Planning Title：夏期基幹教育院ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2017.8 Role：Planning Title：学部混合・全学一斉展開型科目開発のためのワークショップ「基幹教育セミナー」公開体験授業

Organizer：University-wide
2017.3 Role：Participation Title：FD講演会「TA制度改革と大学・大学院教育改善：広島大学を事例として」

Organizer：University-wide
2017.3 Role：Participation Title：外国学修歴・資格評価セミナー「外国学修歴・資格評価セミナー（東洋大学）への出張報告」

Organizer：University-wide
2017.3 Role：Participation Title：M2B講習会(FD)

Organizer：Undergraduate school department
2017.3 Role：Moderator Title：これからの基幹教育を考える

Organizer：University-wide
2017.3 Role：Planning Title：基幹教育院FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2017.2 Role：Participation Title：PBLワークショップ「教養教育におけるシナリオ型PBLの実践」

Organizer：University-wide
2017.2 Role：Participation Title：FD講演会「学位プログラムとカリキュラム設計 ―チューニングの方法論に学ぶ―」

Organizer：University-wide
2017.1 Role：Planning Title：文理融合型科目開発のための公開授業・ワークショップ～「課題協学科目」の実践から～

Organizer：University-wide
2017.1 Role：Participation Title：PBL講演会「PBL（problem-based learning）問題基盤型学習について」

Organizer：University-wide
2016.12 Role：Participation Title：FD研修会「3ポリシー・ガイドラインの活用とカリキュラム設計」

Organizer：University-wide
2016.9 Role：Planning Title：夏期基幹教育院ＦＤ

Organizer：[Undergraduate school/graduate school/graduate faculty]
2016.3 Role：Planning Title：基幹教育院冬期FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2016.2 Role：Participation Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2015.3 Role：Planning Title：基幹教育セミナーFD

Organizer：University-wide
2015.3 Role：Participation Title：平成26年度九州大学全学FD（キャンパスライフ・健康支援センター講演会）　　「障害学生支援におけるバリアフリー―合理的配慮をめぐって―」

Organizer：University-wide
2015.2 Role：Planning Title：基幹教育院冬期FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.8 Role：Planning Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2014.3 Role：Moderator Title：基幹教育セミナー科目実践FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2013.9 Role：Participation Title：課題協学科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2013.8 Role：Planning Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2012.3 Role：Participation Title：平成23年度九大理学府FD/HD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2011.2 Role：Participation Title：平成22年度九大理学府FD/HD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2009.3 Role：Planning Title：平成20年度九大理学部化学科FD/HD

Organizer：Undergraduate school department
2009.3 Role：Participation Title：平成20年度九大理学府FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2008.9 Role：Participation Title：平成２０年度第２回全学ＦＤ

Organizer：University-wide
2007.3 Role：Participation Title：平成18年度九大理学部化学科FD/HD講演会

Organizer：Undergraduate school department
2005.3 Role：Participation Title：平成16年度九大理学部化学科FD/HD講演会

Organizer：Undergraduate school department
2005.3 Role：Participation Title：平成16年度九大理学部FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2004.4 Role：Participation Title：平成16年度第１回全学FD

Organizer：University-wide

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Other educational activity and Special note

2022 Special Affairs
2022 Special Affairs
2013 Class Teacher
2012 Class Teacher
2011 Class Teacher
2010 Class Teacher
2009 Class Teacher
2008 Class Teacher
2007 Class Teacher
2006 Class Teacher
2004 Class Teacher

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Outline of Social Contribution and International Cooperation activities

特になし

Social Activities

２０１２年度　魁講座Ⅲ：天然物と合成物　〜薬と毒〜

山口県立徳山高等学校 2013.3

　More details

Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
APIPS-JPS2004市民フォーラム　生命（いのち）を守り、健康をつくるアミノ酸・ペプチド

日本ペプチド学会福岡国際会議場 2004.10

　More details

Audience： General,　Scientific,　Company,　Civic organization,　Governmental agency

Type：Lecture
平成16年度八幡高校訪問授業（課題研究）

福岡県立八幡高校 2004.3

　More details

Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop
平成15年度八幡高校訪問授業（課題研究）

福岡県立八幡高校 2003.3

　More details

Audience： Infants,　Schoolchildren,　Junior students,　High school students

Type：Seminar, workshop

Travel Abroad

2003.11 - 2004.1

Staying countory name 1：Italy Staying institution name 1：Istitute Superiori di Sanita