Faculty Profiles - ITOH TAICHI

Information

写真a

ITOH TAICHI

Organization

Faculty of Arts and Science Division for Experimental Natural Science Associate Professor
Graduate School of Systems Life Sciences Department of Systems Life Sciences（Concurrent）

Contact information

Tel

0928025840

Profile

Comprehensive analysis of the sleep regulation

Homepage

https://www.artsci.kyushu-u.ac.jp/~chronobiology/
研究室ホームページ

External link

Research Areas

Life Science / Genetics
Life Science / Neuroscience-general
Life Science / Animal physiological chemistry, physiology and behavioral biology
Life Science / Molecular biology

Degree

Doctor of Science （ 2012.3 Kyushu University ）

Research History

Kyushu University Faculty of Arts and Science Division for Experimental Natural Science Associate Professor

2023.4
Kyushu University 基幹教育院　自然科学実験系部門 Assistant Professor

2017.4 - 2023.3
Kyushu University 理学研究院生物科学部門 Assistant Professor

2015.9 - 2017.3
Northwestern University Neurobiology Academic Researcher

2012.4 - 2015.8

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Country：United States

Education

Kyushu University システム生命科学府

2009.4 - 2012.3
Kyushu University 理学府生物科学専攻

2007.4 - 2009.3
Kyushu University 理学部生物学科

2003.4 - 2007.3

Research Interests・Research Keywords

Research theme： The evolution of sleep

Keyword： The evolution of sleep

Research period： 2025
Research theme： The origin of sleep

Keyword： The origin of sleep

Research period： 2025
Research theme： Sleep

Keyword： Sleep

Research period： 2025
Research theme： Circadian rhythm

Keyword： Circadian rhythm

Research period： 2025
Research theme： Clock genes

Keyword： Clock genes

Research period： 2025
Research theme： Circadian clock

Keyword： Circadian clock

Research period： 2025
Research theme： Hydra

Keyword： Hydra

Research period： 2025
Research theme： Drosophila

Keyword： Drosophila

Research period： 2025
Research theme： Behavioral analysis of Hydra

Keyword： Hydra, Nerve nets, clock genes

Research period： 2018.4
Research theme： Identifying new clock genes in Drosophila

Keyword： Clock genes Drosophila melanogaster

Research period： 2007.4

Awards

特に優れた業績による奨学金返還免除（全額）

2009.5 日本学生支援機構

Papers

Effect of temperature cycles on the sleep-like state in Hydra vulgaris Reviewed

Aya Sato, Manabu Sekiguchi, Koga Nakada, Taishi Yoshii, Taichi Q. Itoh

Zoological Letters 11 ( 1 ) 2 2025.1 （ ISSN:2056-306X eISSN:2056-306X ）

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Authorship：Last author,　Corresponding author Language：English Publishing type：Research paper (scientific journal) Publisher：Springer Science and Business Media LLC

Abstract

Background

Sleep is a conserved physiological phenomenon across species. It is mainly controlled by two processes: a circadian clock that regulates the timing of sleep and a homeostat that regulates the sleep drive. Even cnidarians, such as Hydra and jellyfish, which lack a brain, display sleep-like states. However, the manner in which environmental cues affect sleep-like states in these organisms remains unknown. In the present study, we investigated the effects of light and temperature cycles on the sleep-like state in Hydra vulgaris.

Results

Our findings indicate that Hydra responds to temperature cycles with a difference of up to 5° C, resulting in decreased sleep duration under light conditions and increased sleep duration in dark conditions. Furthermore, our results reveal that Hydra prioritizes temperature changes over light as an environmental cue. Additionally, our body resection experiments show tissue-specific responsiveness in the generation ofthe sleep-like state under different environmental cues. Specifically, the upper body can generate the sleep-like state in response to a single environmental cue. In contrast, the lower body did not respond to 12-h light–dark cycles at a constant temperature.

Conclusions

These findings indicate that both light and temperature influence the regulation of the sleep-like state in Hydra. Moreover, these observations highlight the existence of distinct regulatory mechanisms that govern patterns of the sleep-like state in brainless organisms, suggesting the potential involvement of specific regions for responsiveness of environmental cues for regulation of the sleep-like state.

DOI： 10.1186/s40851-025-00248-1

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Other Link： https://link.springer.com/article/10.1186/s40851-025-00248-1/fulltext.html
Symbiont specificity differs among green hydra strains Reviewed International journal

Ryo Miyokawa, Maki Hanada, Yumiko Togawa, Taichi Q. Itoh, Yoshitaka Kobayakawa, Junko Kusumi

Royal Society Open Science 9 ( 10 ) 220789 2022.10 （ ISSN:2054-5703 eISSN:2054-5703 ）

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Language：English Publishing type：Research paper (scientific journal) Publisher：The Royal Society

The symbiotic hydra Hydra viridissima has a stable symbiotic relationship with the green alga Chlorella . This hydra appears to cospeciate with the symbiotic alga, and some strains are known to have strain-specific host/symbiont combinations. To investigate the mechanism of the specificity between host and symbiont, we explored the effect of the removal or exchange of symbionts in two distantly related H. viridissima strains (K10 and M9). In the K10 strain, severe morphological and behavioural changes were found in symbiont-removed and symbiont-exchanged polyps. Interestingly, both polyps showed a similar gene expression pattern. The gene ontology (GO) enrichment analysis revealed that the removal or exchange of symbionts caused the downregulation of genes involved in the electron transport chain and the upregulation of genes involved in translation in the K10 strain. On the other hand, symbiont-removed and symbiont-exchanged M9 polyps showed modest changes in their morphology and behaviour compared with the K10 strain. Furthermore, the patterns of the gene expression changes in the M9 strain were quite different between the symbiont-removed and symbiont-exchanged polyps. Our results suggested that the regulation of energy balance is one of the crucial mechanisms for maintaining symbiotic relationships in green hydra, and this mechanism differs between the strains.

DOI： 10.1098/rsos.220789

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Other Link： https://royalsocietypublishing.org/doi/full-xml/10.1098/rsos.220789
period Translation as a Core Mechanism Controlling Temperature Compensation in an Animal Circadian Clock International journal

Taichi Q. Itoh, Evrim Yildirim, Satya Surabhi, Rosemary Braun, Ravi Allada

bioRxiv 2022.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.1101/2022.02.21.481387
A sleep-like state in Hydra unravels conserved sleep mechanisms during the evolutionary development of the central nervous system Reviewed

Hiroyuki J. Kanaya, Sungeon Park, Ji-hyung Kim, Junko Kusumi, Sofian Krenenou, Etsuko Sawatari, Aya Sato, Jongbin Lee, Hyunwoo Bang, Yoshitaka Kobayakawa, Chunghun Lim, Taichi Q. Itoh

Science Advances 6 ( 41 ) eabb9415 - eabb9415 2020.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1126/sciadv.abb9415
Hydra vulgaris exhibits day-night variation in behavior and gene expression levels Reviewed

Hiroyuki J. Kanaya, Yoshitaka Kobayakawa, Taichi Q. Itoh

Zoological Letters 5 ( 1 ) 2019.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40851-019-0127-1
Mated Drosophila melanogaster females consume more amino acids during the dark phase Reviewed

Shun Uchizono, Yumi Tabuki, Natsumi Kawaguchi, Teiichi Tanimura, Taichi Q. Itoh

PLOS ONE 12 ( 2 ) e0172886 - e0172886 2017.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0172886
Membrane-bound transporter controls the circadian transcription of clock genes in Drosophila Reviewed

Taichi Q. Itoh, Teiichi Tanimura, Akira Matsumoto

Genes to Cells 16 ( 12 ) 1159 - 1167 2011.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1365-2443.2011.01559.x
Self-assembly cloning: a rapid construction method for recombinant molecules from multiple fragments Reviewed

Akira Matsumoto, Taichi Q. Itoh

BioTechniques 51 ( 1 ) 55 - 56 2011.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2144/000113705
Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature

Nishimura Haruka, Mohamed Z. Elhussiny, Ouchi Yoshimitsu, Haraguchi Shogo, Itoh Q. Taichi, Elizabeth R. Gilbert, Mark A. Cline, Nishimura Shotaro, Hosaka Z. Yoshinao, Takahashi Eiki, John F. Cockrem, Bungo Takashi, Vishwajit S. Chowdhury

Neuropeptides 107 102459 2024.10 （ ISSN:01434179 eISSN:15322785 ）

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Language：English Publisher：Elsevier

High ambient temperatures (HT) can increase diencephalic neuropeptide Y (NPY) expression, and central injection of NPY attenuates heat stress responses while inducing an antioxidative state in the chick spleen. However, there is a lack of knowledge about NPY receptor expression, and its regulation by HT, in the chick spleen. In the current study, male chicks were used to measure the expression of NPY receptors in the spleen and other immune organs under acute (30 vs. 40 ± 1°C for 3 h) or chronic (30 vs. 40 ± 1°C for 3 h/day for 3 days) exposure to HT and in response to central injection of NPY (47 pmol, 188 pmol, or 1 nmol). We found that NPY-Y4 receptor mRNA was expressed in the spleen, but not in other immune organs studied. Immunofluorescence staining revealed that NPY-Y4 receptors were localized in the splenic pulp. Furthermore, NPY-Y4 receptor mRNA increased in the chick spleen under both acute and chronic exposure to HT. Central NPY at two dose levels (47 and 188 pmol) and a higher dose (1 nmol) did not increase splenic NPY-Y4 receptor mRNA expression or splenic epinephrine under HT (35 ± 1°C), and significantly increased 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations under HT (40 ± 1°C). In conclusion, increased expression of NPY-Y4 receptor mRNA in the spleen under HT suggest that Y4 receptor may play physiological roles in response to HT in male chicks.

CiNii Research
The Trissin/TrissinR signaling pathway in the circadian network regulates evening activity in Drosophila melanogaster under constant dark conditions Reviewed International journal

Manabu Sekiguchi, Shun Katoh, Tatsuya Yokosako, Aika Saito, Momoka Sakai, Ayumi Fukuda, Taichi Q. Itoh, Taishi Yoshii

Biochemical and Biophysical Research Communications 704 149705 2024.4 （ ISSN:0006-291X eISSN:1090-2104 ）

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Language：Others Publishing type：Research paper (scientific journal) Publisher：Biochemical and Biophysical Research Communications

The circadian clock in Drosophila is governed by a neural network comprising approximately 150 neurons, known as clock neurons, which are intricately interconnected by various neurotransmitters. The neuropeptides that play functional roles in these clock neurons have been identified; however, the roles of some neuropeptides, such as Trissin, remain unclear. Trissin is expressed in lateral dorsal clock neurons (LNds), while its receptor, TrissinR, is expressed in dorsal neuron 1 (DN1) and LNds. In this study, we investigated the role of the Trissin/TrissinR signaling pathway within the circadian network in Drosophila melanogaster. Analysis involving our newly generated antibody against the Trissin precursor revealed that Trissin expression in the LNds cycles in a circadian manner. Behavioral analysis further demonstrated that flies with Trissin or TrissinR knockout or knockdown showed delayed evening activity offset under constant darkness conditions. Notably, this observed delay in evening activity offset in Trissin<sup>RNAi</sup> flies was restored via the additional knockdown of Ion transport peptide (ITP), indicating that the Trissin/TrissinR signaling pathway transmits information via ITP. Therefore, this pathway may be a key regulator of the timing of evening activity offset termination, orchestrating its effects in collaboration with the neuropeptide, ITP.

DOI： 10.1016/j.bbrc.2024.149705

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Symbiont specificity differs among green hydra strains Reviewed International journal

Ryo Miyokawa, Maki Hanada, Yumiko Togawa, Taichi Q Itoh, Yoshitaka Kobayakawa, Junko Kusumi

Royal Society Open Science 2022.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： https://doi.org/10.1098/rsos.220789
<i>period</i> Translation as a Core Mechanism Controlling Temperature Compensation in an Animal Circadian Clock International coauthorship International journal

Taichi Q. Itoh, Evrim Yildirim, Satya Surabhi, Rosemary Braun, Ravi Allada

bioRxiv 2022.2

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Authorship：Lead author Language：English Publishing type：Research paper (scientific journal) Publisher：Cold Spring Harbor Laboratory

<title>Abstract</title>The most enigmatic of the canonical properties of circadian clocks is temperature compensation where circadian period length is stable across a wide temperature range despite the temperature dependence of most biochemical reactions. While the core mechanisms of circadian clocks have been well described, the molecular mechanisms of temperature compensation are poorly understood especially in animals. A major gap is the lack of temperature compensation mutants that do not themselves unambiguously affect the temperature dependence of the encoded protein. Here we show that null alleles of two genes encoding components of a complex important for translation of the core clock component <italic>period</italic> in circadian pacemaker neurons robustly alter the temperature dependence of circadian behavioral period length. These changes are accompanied by parallel temperature dependent changes in oscillations of the PER protein and are consistent with the model that these translation factors mediate the temperature-dependence of PER translation. Consistent with findings from modeling studies, we find that translation of the key negative feedback factor PER plays an instrumental role in temperature compensation.

DOI： 10.1101/2022.02.21.481387

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連載ユニークな実験動物を用いた医学研究･Vol.14 脳のないヒドラを用いた睡眠研究

伊藤太一

医学のあゆみ 280 ( 4 ) 318 - 323 2022.1 （ ISSN:00392359 ）

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Publisher：医歯薬出版

DOI： 10.32118/ayu28004318

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Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila Reviewed International coauthorship International journal

Bart van Alphen, Samuel Stewart, Marta Iwanaszko, Fangke Xu, Keyin Li, Sydney Rozenfeld, Anujaianthi Ramakrishnan, Taichi Q. Itoh, Shiju Sisobhan, Zuoheng Qin, Bridget C. Lear, Ravi Allada

PLOS Biology 2022.1

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Language：Japanese Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pbio.3001456

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Immature symbiotic system between horizontally transmitted green algae and brown hydra. Reviewed International journal

Ryo Miyokawa, Hiroyuki J Kanaya, Taichi Q Itoh, Yoshitaka Kobayakawa, Junko Kusumi

Scientific reports 11 ( 1 ) 2921 - 2921 2021.2

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1038/s41598-021-82489-6
Glial immune-related pathways as mediators of closed head TBI effects on behavior in Drosophila

Bart van Alphen, Samuel Stewart, Marta Iwanaszko, Fangke Xu, Eugenie Bang, Sydney Rozenfeld, Anujaianthi Ramakrishnan, Taichi Q. Itoh, Rosemary I. Braun, Ravi Allada

BioRxiv 2018.9

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Language：English

DOI： 10.1101/422535
cryptochrome genes form an oscillatory loop independent of the per/tim loop in the circadian clockwork of the cricket Gryllus bimaculatus Reviewed

Atsushi Tokuoka, Taichi Q. Itoh, Shinryo Hori, Outa Uryu, Yoshiki Danbara, Motoki Nose, Tetsuya Bando, Teiichi Tanimura, Kenji Tomioka

Zoological Letters 3 ( 1 ) 2017.12

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1186/s40851-017-0066-7
Deciphering the Genes for Taste Receptors for Fructose in Drosophila. Reviewed International journal

Shun Uchizono, Taichi Q Itoh, Haein Kim, Naoki Hamada, Jae Young Kwon, Teiichi Tanimura

Molecules and cells 40 ( 10 ) 731 - 736 2017.10

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.14348/molcells.2017.0016
Self-assembly cloning: a rapid construction method for recombinant molecules from multiple fragments Reviewed

Akira Matsumoto, Taichi Q. Itoh

BioTechniques 62 ( 1 ) xxi - xxi 2017.1

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.2144/000114507
C-Terminal Binding Protein (CtBP) Activates the Expression of E-Box Clock Genes with CLOCK/CYCLE in Drosophila Reviewed

Taichi Q. Itoh, Akira Matsumoto, Teiichi Tanimura

PLoS ONE 8 ( 4 ) e63113 - e63113 2013.4

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1371/journal.pone.0063113
Genome-wide RNA interference screening for the clock-related gene of ATP-binding cassette transporters in Drosophila melanogaster (Diptera: Drosophilidae) Reviewed

Taichi Q. Itoh, Akira Matsumoto

Applied Entomology and Zoology 47 ( 2 ) 79 - 86 2012.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s13355-012-0091-0
bHLH-ORANGE family genes regulate the expression of E-box clock genes in Drosophila Reviewed

Taichi Q. Itoh, Teiichi Tanimura, Akira Matsumoto

Applied Entomology and Zoology 46 ( 3 ) 391 - 397 2011.8

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1007/s13355-011-0052-z
Point mutations in domain II of the voltage-gated sodium channel gene in deltamethrin-resistant Aedes aegypti (Diptera: Culicidae) Reviewed

Raweewan Srisawat, Narumon Komalamisra, Yuki Eshita, Mingqi Zheng, Katsushige Ono, Taichi Q. Itoh, Akira Matsumoto, Songsak Petmitr, Yupha Rongsriyam

Applied Entomology and Zoology 45 ( 2 ) 275 - 282 2010.5

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1303/aez.2010.275
Period Gene of Bactrocera cucurbitae (Diptera: Tephritidae) Among Strains with Different Mating Times and Sterile Insect Technique Reviewed

Akira Matsumoto, Yui Ohta, Taichi Q. Itoh, Sachiyo Sanada-Morimura, Takashi Matsuyama, Taro Fuchikawa, Tehchi Tanimura, Takahisa Miyatake

ANNALS OF THE ENTOMOLOGICAL SOCIETY OF AMERICA 101 ( 6 ) 1121 - 1130 2008.11

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1603/0013-8746-101.6.1121
A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock. Reviewed International journal

Akira Matsumoto, Maki Ukai-Tadenuma, Rikuhiro G Yamada, Jerry Houl, Kenichiro D Uno, Takeya Kasukawa, Brigitte Dauwalder, Taichi Q Itoh, Kuniaki Takahashi, Ryu Ueda, Paul E Hardin, Teiichi Tanimura, Hiroki R Ueda

Genes & development 21 ( 13 ) 1687 - 700 2007.7

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Language：English Publishing type：Research paper (scientific journal)

DOI： 10.1101/gad.1552207

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Books

Self Assembly (SA)-cloning: A rapid construction method for recombinant molecules from multiple fragments.

Taichi Q. Itoh, Akira Matsumoto（Role：Joint author）

BioTechniques Protocol Guide 2012 2011.12

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Language：English Book type：Scholarly book

Presentations

睡眠の根源的要素の理解に向けて - 分析化学の導入 - Invited

伊藤太一

OIST 進化生物学(Evolutionary Biology)と分析化学のSHINKA (仲間) ワークショップ 2024.12

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Event date： 2024.12

Language：Japanese Presentation type：Symposium, workshop panel (public)

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単純な構造から生じる睡眠制御の理解に向けて. Invited

伊藤太一

生理学研究所研究会極限環境適応 2024 2024.11

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Event date： 2024.11

Language：Japanese

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刺胞動物の睡眠現象とその有用性について Invited

伊藤太一

第六回三融会・武田神経科学シンポジウム 2024.5

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Event date： 2024.5

Language：Japanese Presentation type：Oral presentation (general)

Venue：東京 Country：Japan
睡眠の進化と生理学的意義：下等生物（ヒドラ）から哺乳類まで. Invited

伊藤太一

第101回日本生理学会大会 2024.3

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Event date： 2024.3

Language：English Presentation type：Symposium, workshop panel (public)

Venue：北九州 Country：Japan
脳の起源と睡眠の起源の関係 Invited

伊藤太一

日本発達神経科学会第12回学術集会 2023.11

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Event date： 2023.11 - 2024.11

Language：Japanese Presentation type：Oral presentation (general)

Venue：福岡 Country：Japan
Hydra sleep without a brain Invited International conference

T.Q. Itoh

The 45th Annual Meeting of Japanese Society of Sleep Research / The 30th Annual Meeting of Japanese Society for Chronobiology 2023.9

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Event date： 2023.9 - 2023.10

Language：English Presentation type：Symposium, workshop panel (public)

Venue：横浜 Country：Japan
脳のない生物の睡眠様式ーヒドラをモデルとしてー Invited

伊藤太一

第93回日本動物学会早稲田大会 2022.9

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Event date： 2022.9

Language：Japanese Presentation type：Symposium, workshop panel (public)

Venue：東京 Country：Japan
Circadian and sleep behavior in clockless and brainless animal Hydra. Invited International conference

T.Q. Itoh

The 2nd Korean Biological Rhythm Society Symposium 2021.2

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Language：English

Country：Other
A sleep-like state in Hydra unravels conserved sleep mechanisms. Invited International conference

T.Q. Itoh

SLEEP 2021, the 35th annual meeting of the APSS 2021.6

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Language：English

Country：Other

A sleep-like state in Hydra unravels conserved sleep mechanisms.
ヒドラを用いた睡眠制御効果を有する天然化合物のスクリーニング

木本朝彩、伊藤太一

第47回日本分子生物学会年会 2024.11

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Event date： 2024.11

Language：Japanese Presentation type：Poster presentation
単細胞生物における睡眠評価のための行動定量化手法の開発

中田航芽、野下浩司、伊藤太一

日本動物学会第95回長崎大会 2024.9

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Event date： 2024.9

Language：Japanese Presentation type：Oral presentation (general)
Wnt/β-カテニンシグナル伝達経路によるヒドラの光依存的な睡眠制御

濱上翔梧、佐藤文、金谷啓之、中田航芽、伊藤太一

日本動物学会第95回長崎大会 2024.9

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Event date： 2024.9

Language：Japanese Presentation type：Oral presentation (general)
ヒドラにおける睡眠覚醒サイクルの環境変化に対する応答

関口学、佐藤文、中田航芽、吉井大志、伊藤太一

日本動物学会第95回長崎大会 2024.9

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Event date： 2024.9

Language：Japanese Presentation type：Oral presentation (general)
Zinc acts as an evolutionarily conserved sleep driver International conference

Geunha Choi, Terézia K. Geisseová, Aya Sato, Junko Kusumi, Taichi Q. Itoh, and Chunghun Lim

Korean Drosophila Society 2023.6

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Event date： 2023.6

Language：English

Venue：Korea Country：Korea, Republic of
The effects of environmental factors on sleep in Hydra vulgaris.

佐藤文, 伊藤太一

第29回日本時間生物学会学術大会 2022.12

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Event date： 2022.12

Language：Japanese Presentation type：Poster presentation

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刺胞動物ヒドラの時計と睡眠

金谷啓之, Sungeon Park, Ji-hyung Kim, 楠見淳子, Sofian Krenenou, 猿渡悦子, 佐藤文, Jongbin Lee, Hyunwoo Bang, 小早川義尚, Chunghun Lim, 伊藤太一

第27回日本時間生物学会学術大会 2020.9

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Event date： 2020.9

Language：Japanese

Venue：オンライン Country：Japan
共生ブラウンヒドラにおける遺伝子発現と共生体獲得様式の関係

御代川涼、金谷啓之、伊藤太一、小早川義尚、楠見淳子

日本動物学会第91回大会 2020.9

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Event date： 2020.9

Language：Japanese

Country：Japan
刺胞動物ヒドラにおける睡眠制御の分子的基盤

金谷啓之, 猿渡悦子, 佐藤文, 小早川義尚, 伊藤太一

第42回日本分子生物学会年会 2019.12

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Event date： 2019.12

Language：Japanese

Country：Other
刺胞動物ヒドラにおける睡眠様状態の発見

伊藤太一, 金谷啓之, 猿渡悦子, 佐藤文, 小早川義尚

日本動物学会第90回大阪大会 2019.9

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Event date： 2019.9

Language：Japanese

Country：Japan
Hydra vulgaris exhibits a sleep-like state induced by melatonin Invited International conference

Taichi Q. Itoh

Symposium on insect chronobiology 2019.2

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Event date： 2019.2

Language：English Presentation type：Oral presentation (general)

Country：Japan
Analysis of primitive sleep-wake cycle in hydra

Kanaya H.J., Kobayakawa Y., Itoh T.Q.

第25回日本時間生物学会 2018.10

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Event date： 2018.10

Language：Japanese

Country：Japan
ヒドラにおける睡眠・覚醒サイクルの解析

金谷啓之, 小早川義尚, 伊藤太一

第25回日本時間生物学会学術大会 2018.10

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Event date： 2018.10

Language：Japanese

Country：Other
ショウジョウバエ歩行活動に対する加齢の影響

松本顕, 伊藤太一

第24回日本時間生物学会学術大会 2017.10

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Event date： 2017.10

Language：Japanese

Country：Other

ショウジョウバエ歩行活動に対する加齢の影響
ショウジョウバエ概日リズムの制御メカニズム Invited

伊藤太一

三学会(日本動物・植物・生態学会)合同福岡県例会 2015.12

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Event date： 2015.12

Language：Japanese Presentation type：Oral presentation (general)

Country：Japan
ウリミバエPERによるキイロショウジョウバエper0;tim0の周期性の回復

松本顕, 伊藤太一, 伊藤太一

第20回日本時間生物学会学術大会 2013.10

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Event date： 2013.10

Language：Japanese

Country：Other

ウリミバエPERによるキイロショウジョウバエper0;tim0の周期性の回復
ABCトランスポーターによるショウジョウバエ概日時計の制御

伊藤太一, 谷村禎一, 松本顕

第18回日本時間生物学会学術大会 2011.11

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ABCトランスポーターによるショウジョウバエ概日時計の制御
時計遺伝子clockwork orangeはホモダイマーで機能する

伊藤太一, 谷村禎一, 松本顕

第33回日本分子生物学会年会・第83回日本生化学会大会合同大会 2010.12

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PAP peptide coded in pdf gene is necessary to persist the circadian locomotor rhythm in insect. International conference

M. Shimohigashi, T.Q. Itoh, T. Honda, H. Tsuzuki, M. Saito, K, Koga K, Takahashi A. Matsushima, R. Ueda, T. Tanimura, H. Nakagawa, A. Matsumoto, Y. Shimohigashi

3rd Asia-Pacific International Peptide Symposium (APIPS 2009) 2009.11

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PAP peptide coded in pdf gene is necessary to persist the circadian locomotor rhythm in insect.
環境ホルモン・ビスフェノールA暴露によるショウジョウバエの行動リズム変異

下東美樹, 府本優, 伊藤太一, LIU Xiaohui, 松島綾美, 谷村禎一, MEINERTZHAGEN Ian A., 中川裕之, 松本顕, 下東康幸

環境ホルモン学会第11回研究発表会 2008.12

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環境ホルモン・ビスフェノールA暴露によるショウジョウバエの行動リズム変異
bHLH-ORANGEファミリー遺伝子による時計遺伝子の発現調節

伊藤太一, 高橋邦明, 鵜飼(蓼沼)麿貴, 上田泰己, 上田龍, 谷村禎一, 松本顕

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008.12

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bHLH‐ORANGEファミリー遺伝子による時計遺伝子の発現調節
ショウジョウバエを実験モデルとした環境ホルモン・ビスフェノールAの継代試験

下東美樹, 府本優, 伊藤太一, 堤俊博, LIU Xiaohui, 松島綾美, 谷村禎一, MEINERTZHAGEN Ian A., 松本顕, 下東康幸

第31回日本分子生物学会年会・第81回日本生化学会大会合同大会 2008.12

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ショウジョウバエを実験モデルとした環境ホルモン・ビスフェノールAの継代試験
bHLH-ORANGEファミリー遺伝子による時計遺伝子の発現調節

伊藤太一, 高橋邦明, 鵜飼(蓼沼)磨貴, 上田泰己, 上田龍, 谷村禎一, 松本顕

第15回日本時間生物学会学術大会 2008.10

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bHLH‐ORANGEファミリー遺伝子による時計遺伝子の発現調節
ショウジョウバエ歩行活動リズムの形成にペプチドPAPが必須である

松本顕, 伊藤太一, 齋藤緑, 古賀啓太, 高橋邦明, 松島綾美, 上田龍, 谷村禎一, 下東康幸, 中川裕之, 下東美樹

第15回日本時間生物学会学術大会 2008.10

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ショウジョウバエ歩行活動リズムの形成にペプチドPAPが必須である
CWO negatively regulates circadian transcription with bHLH-ORANGE family genes International conference

Taichi Q. Itoh, Kuniaki Takahashi, Maki Ukai-Tadenuma, Hiroki R. Ueda, Ryu Ueda, Teiichi Tanimura, Akira Matsumoto

The 12th European Drosophila Neurobiology Conference (Neurofly 2008) 2008.9

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Event date： 2008.9

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CWO negatively regulates circadian transcription with bHLH-ORANGE family genes
A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock International conference

Rikuhiro Yamada, Akira Matsumoto, Maki T. Ukai, Jerry Houl, Kenichiro Uno, Takeya Kasukawa, Brigitte Dauwalder, Taichi Itoh, Paul Hardin, Teiichi Tanimura, Hiroki Ueda

NEUROSCIENCE RESEARCH 2008.1

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A functional genomics strategy reveals half-type ABC transporters regulate circadian rhythm in Drosophila International conference

T.Q. Itoh, K. Takahashi, R. Ueda, T. Tanimura, A. Matsumoto

International Symposium “Comprehensive understanding of diverse biological timing mechanism” 2007.11

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A functional genomics strategy reveals half-type ABC transporters regulate circadian rhythm in Drosophila
E23 controls Drosophila circadian rhythm to modulate the clock gene vrille expression through a molting steroid hormone response. Neurobiology of Drosophila. International conference

T.Q. Itoh, T. Tanimura, A. Matsumoto

Neurobiology of Drosophila 2011.10

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E23 controls Drosophila circadian rhythm to modulate the clock gene vrille expression through a molting steroid hormone response. Neurobiology of Drosophila.
A membrane-bound transporter controls the circadian transcription of clock genes in Drosophila. International Symposium “Designing the circadian clock International conference

T.Q. Itoh, T. Tanimura, A. Matsumoto

Designing the circadian clock 2011.11

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A membrane-bound transporter controls the circadian transcription of clock genes in Drosophila. International Symposium “Designing the circadian clock
ショウジョウバエ時計遺伝子発現に対するCtBPの作用

松本顕, 伊藤太一

第19回日本時間生物学会学術大会 2012.9

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Biochronicity Applications to Neurodegenerative Disease: Amyotrophic Lateral Sclerosis and Ataxin2. Invited International conference

T.Q. Itoh, A. Hutchison, F. Xu, K. White, A. Dinner, R. Allada

DARPA Biochronicity Program Midpoint Review 2014.1

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Biochronicity Applications to Neurodegenerative Disease: Amyotrophic Lateral Sclerosis and Ataxin2.
Molecular Pathways Linking Circadian Clocks and Neurodegeneration Diseases. International conference

F. Xu, T.Q. Itoh, E. Kula-Eversole, A Hutchison, P. Jiang, K. White, A. Dinner, R. Allada

Cold Spring Harbor Asia Conferences, Biological Rhythms 2015.10

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Molecular Pathways Linking Circadian Clocks and Neurodegeneration Diseases.
Circadian Clocks Modulate Huntington’s Disease via Stress Response Pathways. International conference

F. Xu, T.Q. Itoh, E. Kula-Eversole, A. Hutchison, K. White, A. Dinner, R. Allada

Society for Research on Biological Rhythms meeting. 2016.5

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Circadian Clocks Modulate Huntington’s Disease via Stress Response Pathways.
Gr64a–f genes contribute to the variation of fructose sensitivity in natural population of Drosophila melanogaster

内園駿, 伊藤太一, 谷村禎一

第12回日本ショウジョウバエ研究会(JDRC12) 2016.9

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Gr64a–f genes contribute to the variation of fructose sensitivity in natural population of Drosophila melanogaster
Diurnal changing in feeding amount of amino acids in Drosophila melanogaster

伊藤太一, 内園駿, 田吹由美, 川口夏海, 谷村禎一

第12回日本ショウジョウバエ研究会(JDRC12) 2016.9

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Diurnal changing in consumption of amino acids in Drosophila melanogaster

田吹由美, 内園駿, 川口夏海, 谷村禎一, 伊藤太一

第23回日本時間生物学会学術大会 2016.10

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Diurnal changing in consumption of amino acids in Drosophila melanogaster
Polymorphic sugar taste sensitivity in a natural population of Drosophila melanogaster

内園駿, 伊藤太一, 谷村禎一

第87回日本動物学会年会 2016.11

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刺胞動物ヒドラにおける進化的に保存された睡眠メカニズム

金谷啓之, Sungeon Park, Ji-hyung Kim, 楠見淳子, Sofian Krenenou, 猿渡悦子, 佐藤文, Jongbin Lee, Hyunwoo Bang, 小早川義尚, Chunghun Lim, 伊藤太一

生理学研究所研究会「細胞システム理解のためのシグナル応答原理解明の最前線」 2020.9

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刺胞動物ヒドラと共生緑藻の細胞内共生における相互作用

御代川涼, 伊藤太一, 小早川義尚, 楠見淳子

日本植物学会第85回大会 2021.9

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ヒドラを用いた睡眠制御化合物の探索

佐藤文, 金谷啓之, 伊藤太一

第92回日本動物学会オンライン米子大会 2021.9

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MISC

刺胞動物を用いた概日リズム・睡眠研究 Reviewed

金谷啓之、伊藤太一

日本時間生物学会学会誌 2022.11

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ヒドラが解き明かす睡眠の進化的起源

金谷啓之、伊藤太一

実験医学, 羊土社 2022.6

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脳のないヒドラを用いた睡眠研究--睡眠現象をよりシンプルに理解する

伊藤太一

医学のあゆみ 2022.1

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行動睡眠メカニズム研究のモデルとしてのヒドラの有用性

伊藤太一

バイオインダストリー協会(JBA)「バイオサイエンスとインダストリー(B&I)」 2021.5

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動物はいつから眠るようになったのか？ – 脳のないヒドラから睡眠の起源を探る

佐藤文, 金谷啓之, 伊藤太一

academist Journal 2020.12

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Genetics of Circadian Rhythms Reviewed

Tomas S. Andreani, Taichi Q. Itoh, Evrim Yildirim, Dae-Sung Hwangbo, Ravi Allada

2015.12

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Genetics of Circadian Rhythms

DOI： 10.1016/j.jsmc.2015.08.007
ショウジョウバエを用いた概日測時機構解析の40年-第2部ショウジョウバエ再び-

伊藤太一, 松本顕

時間生物学 2013.10

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ショウジョウバエを用いた概日測時機構解析の40年―第2部ショウジョウバエ再び―
ショウジョウバエを用いた概日測時機構解析の40年-第1部ショウジョウバエは再びとべるか?-

伊藤太一, 松本顕

時間生物学 2013.6

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ショウジョウバエを用いた概日測時機構解析の40年―第1部ショウジョウバエは再びとべるか?―
刺胞動物を用いた概日リズム・睡眠研究 Invited Reviewed

金谷啓之, 伊藤太一

時間生物学 28 ( 2 ) 87 - 93 2022.11

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【睡眠医学-眠りの分子・神経基盤を解明し、睡眠異常へ介入する】ヒドラが解き明かす睡眠の進化的起源

金谷啓之, 伊藤太一

実験医学 40 ( 11 ) 1724 - 1729 2022.7 （ ISSN:0288-5514 ）

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睡眠は動物において普遍的にみられる現象である。哺乳類はもちろんのこと、ショウジョウバエや線虫も睡眠をとる。近年の研究により、睡眠の起源は中枢神経系をもたない刺胞動物まで遡ることが明らかになった。われわれは、刺胞動物の一種であるヒドラをモデルに据え、睡眠の進化的起源を探る研究を展開している。ヒドラには、可逆的な行動静止、反応性の低下、睡眠恒常性を伴った睡眠様状態が存在し、さらにはその制御因子が他の生物と共通していることがわかった。ヒドラを用いた睡眠研究は、「生物はなぜ眠るのか」という問いに答える一助となるだろう。(著者抄録)
Hydra unravels the origin of sleep Invited

金谷啓之, 伊藤太一

実験医学 40 ( 11 ) 1724 - 1729 2022.6

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ユニークな実験動物を用いた医学研究(Vol.14)　脳のないヒドラを用いた睡眠研究　睡眠現象をよりシンプルに理解する

伊藤太一

医学のあゆみ 280 ( 4 ) 318 - 323 2022.1 （ ISSN:0039-2359 ）

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睡眠研究はヒトやマウスなどの哺乳類を対象として発展してきたが、近年ではショウジョウバエや線虫などの無脊椎動物をモデル生物として用いた研究も盛んになっている。その理由のひとつに、睡眠制御における分子機構の進化的保存性の高さがあげられる。ならば、より下等な動物をモデル系として睡眠研究に導入することができれば、その分子機構の解明に貢献し、さらには睡眠現象の起源にまで迫ることができるかもしれない。筆者らは最近、進化的に脳を獲得する以前の動物群である刺胞動物のヒドラにも睡眠現象が存在していることを発見した。また、その分子機構が高等動物との間で進化的に保存されていることも明らかにした。ヒドラの持つ実験動物としてのさまざまな特徴をいかすことで、睡眠研究に新知見をもたらす新たなモデル系を確立する道がひらけたといえる。(著者抄録)
Ataxin-2: A versatile posttranscriptional regulator and its implication in neural function. Reviewed

Jongbo Lee, Minjong Kim, Taichi Q Itoh, Chunghun Lim

Wiley interdisciplinary reviews. RNA 2018.11

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Ataxin-2 (ATXN2) is a eukaryotic RNA-binding protein that is conserved from yeast to human. Genetic expansion of a poly-glutamine tract in human ATXN2 has been implicated in several neurodegenerative diseases, likely acting through gain-of-function effects. Emerging evidence, however, suggests that ATXN2 plays more direct roles in neural function via specific molecular and cellular pathways. ATXN2 and its associated protein complex control distinct steps in posttranscriptional gene expression, including poly-A tailing, RNA stabilization, microRNA-dependent gene silencing, and translational activation. Specific RNA substrates have been identified for the functions of ATXN2 in aspects of neural physiology, such as circadian rhythms and olfactory habituation. Genetic models of ATXN2 loss-of-function have further revealed its significance in stress-induced cytoplasmic granules, mechanistic target of rapamycin signaling, and cellular metabolism, all of which are crucial for neural homeostasis. Accordingly, we propose that molecular evolution has been selecting the ATXN2 protein complex as an important trans-acting module for the posttranscriptional control of diverse neural functions. This explains how ATXN2 intimately interacts with various neurodegenerative disease genes, and suggests that loss-of-function effects of ATXN2 could be therapeutic targets for ATXN2-related neurological disorders. This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

DOI： 10.1002/wrna.1488
アミノ酸はいつ必要？ – ショウジョウバエのメスは交尾後の夜にアミノ酸を多く摂取する

内園駿, 伊藤太一

academist Journal 2017.3

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アメリカNorthwestern大学でのポスドク生活

伊藤太一

時間生物学 2016.11

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Professional Memberships

日本比較生理生化学会

2021.5 - Present

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THE ZOOLOGICAL SOCIETY OF JAPAN

2010.4 - Present

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THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

2008.8 - Present

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JAPANESE SOCIETY FOR CHRONOBIOLOGY

2008.8 - Present

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Committee Memberships

日本時間生物学会 Councilor Domestic

2017.4 - 2029.3

Research Projects

動物に普遍的な睡眠制御因子の網羅的検索とその作用機序の同定

Grant number：25K02311 2025.4 - 2029.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

伊藤太一, 小野大輔

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本研究では、脳構造をもたない刺胞動物ヒドラをモデルに、進化的に保存された睡眠制御因子およびその分子機序の解明を目指す。化合物ライブラリーを用いた表現型スクリーニングにより、睡眠に影響を及ぼす候補化合物を同定し、さらにオミクス解析により睡眠様状態に特異的な分子群を網羅的に抽出する。加えて、ヒドラで同定された因子の作用機序や睡眠制御機構がショウジョウバエおよびマウスといった異なる進化段階の動物でも再現されるかを検証し、その機能の進化的保存性を評価することで、睡眠制御に共通する普遍的な分子基盤の解明を目指す。

CiNii Research
睡眠ステージの進化的起源の解明

2024.8 - 2025.7

公益信託成茂動物科学振興基金令和6年度研究助成

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新規スクリーニング法による睡眠改善効果を有する天然化合物の探索

2024 - 2026

加藤記念研究助成

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刺胞動物をモデルとした睡眠制御因子の網羅的同定

2022 - 2027

武田科学振興財団ライフサイエンス研究助成

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なぜメスはオスよりも寿命が長いのか？

Grant number：22K11886 2022 - 2024

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

松本綾子, 松本顕, 伊藤太一

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ヒトを含めた多くの生物でメスはオスよりも長寿である。本研究では、寿命の性差の原因遺伝子を同定する。実験には、寿命が短く、短期間で結果が得られるショウジョウバエを用いる。まず、老齢群および若齢群の脳での遺伝子発現を、雌雄で網羅的に比較する。加齢により性特異的に発現変化する遺伝子群を対象に、バイオインフォ解析で、それらの調節領域内のコンセンサス配列を探索し、その配列に結合する調節因子を同定する。これらメス長寿化マスターキー遺伝子候補について、生体内での機能解析を行い、加齢の進行や寿命への影響を検証する。

CiNii Research
Sleep study in nerve-free Hydra

Grant number：22K19313 2022 - 2023

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Challenging Research(Exploratory)

伊藤太一, 楠見淳子, 松本顕

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近年我々のグループは刺胞動物のヒドラが眠っていることを分子レベルで実証し、これにより、睡眠の起源は動物が脳を獲得するよりも古いことが示された。そこで、次の問いとして、『神経系は睡眠に必須なのか』を検証する。ヒドラでは薬剤処理によって神経系を喪失させることが可能である。この全く動けない『寝たきり』状態のヒドラが眠っているのかどうかを分子レベルで判定し、睡眠には神経系が必須要素なのかどうかを判断する。これは、これまで当然と考えられてきた「睡眠は神経系が担う」という通説に挑む研究である。

CiNii Research
ヒドラ睡眠制御アトラスの構築

2022 - 2023

日揮実吉奨学会研究助成

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ヒドラにおける睡眠量の雌雄差とオルニチン作用機序の関係性の解明

2022 - 2023

稲盛財団研究助成

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脳を持たないヒドラで探る眠りの起源と変遷

Grant number：23K21322 2021.4 - 2025.3

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

伊藤太一, 楠見淳子, 吉井大志, 寺本孝行

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睡眠は高等脊椎動物で普遍的に見られる生理現象であるが、その起源と進化的変遷は解明されていない。そこで、本研究ではヒドラの睡眠制御機序を分子レベルと細胞レベルで解析し、これらを統合してヒドラの睡眠制御の全容の理解を目指す。本研究の結果と他の動物種で得られている知見を比較することで、睡眠の起源と進化的変遷が解明できると期待される。

CiNii Research
脳を持たないヒドラで探る眠りの起源と変遷

Grant number：21H02527 2021 - 2024

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)

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Epigenetic control of age-induced circadian oscillations and its adaptive effects on fitness

Grant number：21K19277 2021 - 2022

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Challenging Research(Exploratory)

Matsumoto Akira

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Authorship：Coinvestigator(s) Grant type：Scientific research funding

The final goal of this study is to elucidate the expression mechanism of the late-life cycler, which begins to show a clear circadian oscillation with aging in the Drosophila brain. First, we analyzed changes of genome modification by aging using ATAC-seq analysis. We also performed bioinformatic analyses, clustering, upstream analysis, and KEGG analysis, of gene expression profiles in young and old flies. In conclusion, we identified one GATA factor, whose expression is induced with age, as one of candidates of the master genes for late-life cycler, as well as two transcription factors related to the GATA factor.

CiNii Research
睡眠制御における進化発生学的解析

2021 - 2022

Japan Society for the Promotion of Science Bilateral program

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Authorship：Principal investigator Grant type：Joint research
新規表現型スクリーニング法による睡眠制御化合物の探索

2020 - 2022

住友財団基礎科学研究助成

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Authorship：Principal investigator Grant type：Contract research
脳および時計遺伝子非依存的な睡眠制御メカニズムの解明

2019

2019年度QRプログラム

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
概日リズム温度補償性の新規制御因子の解析

Grant number：18K14749 2018 - 2020

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Early-Career Scientists

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Authorship：Principal investigator Grant type：Scientific research funding
散在神経系のヒドラを用いた睡眠の起源の解明

2018 - 2020

住友財団基礎科学研究助成

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Authorship：Principal investigator Grant type：Contract research
Hydra vulgaris exhibits day-night variation in behavioral and gene expression levels

2018

九州大学研究活動基礎支援制度平成30年度「外国語校閲経費支援」

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
Mated Drosophila melanogaster females consume more amino acids during the dark phase

2017

九州大学研究活動基礎支援制度平成28年度「外国語校閲経費支援」

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
加齢に伴う睡眠相の断片化に関わる神経回路網と分子メカニズムの同定

Grant number：16K07444 2016 - 2019

Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)

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Authorship：Coinvestigator(s) Grant type：Scientific research funding
筋萎縮性側索硬化症(ALS)の原因遺伝子であるRNA結合タンパク質のターゲット検索

2016

平成28年度QRプログラム

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Authorship：Principal investigator Grant type：On-campus funds, funds, etc.
膜輸送体ABCトランスポーターによる概日リズム制御機構の行動分子遺伝学的解析

2009 - 2011

Japan Society for the Promotion of Science Research Fellowships for Young Scientists

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Authorship：Principal investigator Grant type：Joint research

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Class subject

生物科学Ⅱ

2025.10 - 2025.12 Fall quarter
学術アプローチ科目

2025.10 - 2025.12 Fall quarter
生命の科学Ａ

2025.6 - 2025.8 Summer quarter
基幹教育セミナー

2025.6 - 2025.8 Summer quarter
生命の科学Ａ

2025.4 - 2025.6 Spring quarter
課題協学科目

2024.10 - 2025.3 Second semester
Basic BiologyⅡ

2024.10 - 2024.12 Fall quarter
生物科学Ⅱ

2024.10 - 2024.12 Fall quarter
基幹教育セミナー

2024.6 - 2024.8 Summer quarter
生命の科学Ａ

2024.6 - 2024.8 Summer quarter
生命の科学Ａ

2024.4 - 2024.6 Spring quarter
課題協学科目

2023.10 - 2024.3 Second semester
基幹教育セミナー

2023.6 - 2023.8 Summer quarter
生命の科学Ａ

2023.6 - 2023.8 Summer quarter
基幹教育セミナー

2023.6 - 2023.8 Summer quarter
自然科学総合実験

2023.4 - 2023.6 Spring quarter
生命の科学Ａ

2023.4 - 2023.6 Spring quarter
基礎科学実習

2022.12 - 2023.2 Winter quarter
基礎科学実習

2022.12 - 2023.2 Winter quarter
自然科学総合実験

2022.10 - 2022.12 Fall quarter
自然科学総合実験

2022.10 - 2022.12 Fall quarter
基幹教育セミナー

2022.6 - 2022.8 Summer quarter
自然科学総合実験

2022.4 - 2022.6 Spring quarter
自然科学総合実験

2022.4 - 2022.6 Spring quarter
基礎科学実習

2021.12 - 2022.2 Winter quarter
基礎科学実習

2021.12 - 2022.2 Winter quarter
自然科学総合実験

2021.10 - 2021.12 Fall quarter
自然科学総合実験

2021.10 - 2021.12 Fall quarter
自然科学総合実験（発展）

2021.6 - 2021.8 Summer quarter
基幹教育セミナー

2021.6 - 2021.8 Summer quarter
自然科学総合実験（基礎）

2021.4 - 2021.6 Spring quarter
自然科学総合実験（発展）

2020.12 - 2021.2 Winter quarter
自然科学総合実験（基礎）

2020.10 - 2020.12 Fall quarter
基幹教育セミナー

2020.6 - 2020.8 Summer quarter
自然科学総合実験（発展）

2020.6 - 2020.8 Summer quarter
自然科学総合実験（基礎）

2020.4 - 2020.6 Spring quarter
自然科学総合実験（発展）

2019.12 - 2020.2 Winter quarter
自然科学総合実験（発展）

2019.12 - 2020.2 Winter quarter
自然科学総合実験（基礎）

2019.10 - 2019.12 Fall quarter
自然科学総合実験（基礎）

2019.10 - 2019.12 Fall quarter
自然科学総合実験（基礎）

2019.10 - 2019.12 Fall quarter
基幹教育セミナー

2019.6 - 2019.8 Summer quarter
自然科学総合実験（発展）

2019.6 - 2019.8 Summer quarter
自然科学総合実験（発展）

2019.6 - 2019.8 Summer quarter
自然科学総合実験（発展）

2019.6 - 2019.8 Summer quarter
自然科学総合実験（基礎）

2019.4 - 2019.6 Spring quarter
自然科学総合実験（基礎）

2019.4 - 2019.6 Spring quarter
自然科学総合実験（基礎）

2019.4 - 2019.6 Spring quarter
自然科学総合実験（発展）

2018.12 - 2019.2 Winter quarter
自然科学総合実験（基礎）

2018.10 - 2018.12 Fall quarter
基幹教育セミナー

2018.6 - 2018.8 Summer quarter
自然科学総合実験（発展）

2018.6 - 2018.8 Summer quarter
自然科学総合実験（発展）

2018.6 - 2018.8 Summer quarter
自然科学総合実験（発展）

2018.6 - 2018.8 Summer quarter
自然科学総合実験（基礎）

2018.4 - 2018.6 Spring quarter
自然科学総合実験（基礎）

2018.4 - 2018.6 Spring quarter
自然科学総合実験（基礎）

2018.4 - 2018.6 Spring quarter
自然科学総合実験（発展）

2017.12 - 2018.2 Winter quarter
自然科学総合実験（基礎）

2017.10 - 2017.12 Fall quarter
自然科学総合実験（発展）

2017.6 - 2017.8 Summer quarter
基幹教育セミナー

2017.6 - 2017.8 Summer quarter
自然科学総合実験（発展）

2017.6 - 2017.8 Summer quarter
自然科学総合実験

2017.4 - 2017.9 First semester
自然科学総合実験（基礎）

2017.4 - 2017.6 Spring quarter
自然科学総合実験（基礎）

2017.4 - 2017.6 Spring quarter
動物生理学

2016.4 - 2016.9 First semester
自然科学総合実験

2016.4 - 2016.9 First semester
応用細胞機能学実験

2016.4 - 2016.9 First semester
生物学演習I

2015.10 - 2016.3 Second semester

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FD Participation

2025.5 Role：Participation Title：学術アプローチ科目FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2025.5 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2025.3 Role：Participation Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2025.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.5 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.5 Role：Participation Title：課題協学FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2024.3 Role：Participation Title：自殺防止メンタルヘルス研修会

Organizer：University-wide
2024.3 Role：Participation Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.9 Role：Participation Title：課題協学FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.5 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.5 Role：Participation Title：課題協学FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2023.3 Role：Participation Title：基幹教育ガイダンスFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.5 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2022.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.5 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2021.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2020.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2020.6 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.11 Role：Participation Title：メンタルヘルス講演会

Organizer：University-wide
2019.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.4 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2019.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.4 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2018.3 Role：Participation Title：基幹教育院春季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2017.9 Role：Participation Title：基幹教育院夏季FD

Organizer：[Undergraduate school/graduate school/graduate faculty]
2017.4 Role：Participation Title：基幹教育セミナーFD

Organizer：[Undergraduate school/graduate school/graduate faculty]

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Other educational activity and Special note

2025 Class Teacher システム生命科学府学生相談教員
2025 Class Teacher １年次クラス担任（薬学部臨床薬学科）
2024 Class Teacher １年次クラス担任（薬学部臨床薬学科）
2024 Class Teacher システム生命科学府学生相談教員
2023 Class Teacher １年次クラス担任（薬学部臨床薬学科）

Social Activities

長野県諏訪清陵高等学校へのヒドラ提供

2024
大分県立大分舞鶴高等学校へのショウジョウバエ変異体の譲渡

2019

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大分県立大分舞鶴高等学校へのショウジョウバエ変異体の譲渡
平成２９年度グローバルサイエンスキャンパス「世界に羽ばたく未来創成科学者育成プロジェクト（FC-SP）」における高校生への実験指導

2017

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平成２９年度グローバルサイエンスキャンパス「世界に羽ばたく未来創成科学者育成プロジェクト（FC-SP）」における高校生への実験指導
福岡県立糸島農業高校へのショウジョウバエ変異体の譲渡および解説

2017

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福岡県立糸島農業高校へのショウジョウバエ変異体の譲渡および解説
福岡県立戸畑高等学校生物部の研究室訪問および研究紹介

2017

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福岡県立戸畑高等学校生物部の研究室訪問および研究紹介
福岡県研修　産業・理科教育教員派遣研修員の研究指導

2016

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福岡県研修　産業・理科教育教員派遣研修員の研究指導

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Media Coverage

『ガリレオX』にて研究内容の紹介とインタビュー TV or radio program

BSフジ 2024.4

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『ガリレオX』にて研究内容の紹介とインタビュー
私たちはなぜ眠るのか？最新科学が照らし出す未知の領域 TV or radio program

BSフジガリレオX 2024.4

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researchmap
究極の謎!?“動物の睡眠”徹底解明SP TV or radio program

NHK サイエンスZERO 2023.9

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researchmap
サイエンスZEROにて研究内容の紹介とインタビュー TV or radio program

NHK 2023.9

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サイエンスZEROにて研究内容の紹介とインタビュー
睡眠 TV or radio program

日本テレビカズレーザーと学ぶ。 2023.7

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researchmap
『カズレーザーと学ぶ』　にて研究紹介. TV or radio program

日本テレビ 2023.7

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『カズレーザーと学ぶ』　にて研究紹介.
Which Creature Was the First to Take a Nap? Internet

Springer Nature Scientific American 2023.6

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researchmap
研究紹介とコメントの掲載

Scientific American 2023.6

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研究紹介とコメントの掲載
研究内容の紹介とコメントの掲載 Newspaper, magazine

日本経済新聞 2023.6

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研究内容の紹介とコメントの掲載
睡眠の悩み、原始動物にヒント？クモも夢見る可能性 Newspaper, magazine

日本経済新聞 2023.5

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Author：Other

researchmap
『【新感覚!教育バラエティ】とつげき!ちきゅうの研究室「らぶラボきゅ〜」脳がないのに眠る生き物がいるってホント！？睡眠のフシギ』にて子供向けに研究内容紹介など

Youtube 2021.12

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『【新感覚!教育バラエティ】とつげき!ちきゅうの研究室「らぶラボきゅ〜」脳がないのに眠る生き物がいるってホント！？睡眠のフシギ』にて子供向けに研究内容紹介など
Science誌にて研究内容のハイライトとインタビューの紹介 THE SIMPLEST OF SLUMBERS Evidence from evolutionarily ancient creatures is revealing that sleep is not just for the brain Newspaper, magazine

Science 2021.10

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Science誌にて研究内容のハイライトとインタビューの紹介
THE SIMPLEST OF SLUMBERS Evidence from evolutionarily ancient creatures is revealing that sleep is not just for the brain
脳がないのにクラゲは眠る！「睡眠」の常識を変える最新研究を紹介

Yahoo ニュース 2021.5

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脳がないのにクラゲは眠る！「睡眠」の常識を変える最新研究を紹介
チコちゃんに叱られる!　放送回なぜ生き物は眠るの？にて研究紹介 TV or radio program

NHK 2021.4

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チコちゃんに叱られる!　放送回なぜ生き物は眠るの？にて研究紹介
FOCUS：脳を持たない生物も眠る Newspaper, magazine

科学雑誌Newton 2021.1

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FOCUS：脳を持たない生物も眠る
Hail Hydra! It Seems That Even Brainless Animals Need Sleep

Forbes 2021.1

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Hail Hydra! It Seems That Even Brainless Animals Need Sleep
Sleep evolved before brains did, study finds

msn マイクロソフトニュース 2021.1

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Sleep evolved before brains did, study finds
Did Sleep Precede the Brain?

labroots 2021.1

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Did Sleep Precede the Brain?
Which came first, sleep or the brain?

EurekAlert! 2021.1

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Which came first, sleep or the brain?
動物はいつから眠るようになったのか？ – 脳のないヒドラから睡眠の起源を探る

Academist Journal 2020.12

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動物はいつから眠るようになったのか？ – 脳のないヒドラから睡眠の起源を探る
脳がなくても眠れる!? Newspaper, magazine

山形新聞など各地方紙 2020.11

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脳がなくても眠れる!?
The Sleep of the Hydra

Science and Philosophy 2020.10

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The Sleep of the Hydra
脳がない動物ヒドラに睡眠が存在

LINE NEWS 2020.10

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脳がない動物ヒドラに睡眠が存在
アミノ酸はいつ必要？ – ショウジョウバエのメスは交尾後の夜にアミノ酸を多く摂取する

2016.3

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アミノ酸はいつ必要？ – ショウジョウバエのメスは交尾後の夜にアミノ酸を多く摂取する

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Acceptance of Foreign Researchers, etc.

Hong Kong University of Science and Technology

Acceptance period： 2024.4 - 2024.7 （Period）：1 month or more
AgroParisTech

Acceptance period： 2019.9 - 2020.8

Nationality：France

Travel Abroad

2019.12

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2018.8

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2017.9

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2016.10

Staying countory name 1：Korea, Republic of Staying institution name 1：GIST
2016.10

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2016.4

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2015.12

Staying countory name 1：Korea, Republic of Staying institution name 1：KAIST
2015.12

Staying countory name 1：Korea, Republic of Staying institution name 1：UNIST
2012.4 - 2015.8

Staying countory name 1：United States Staying institution name 1：Northwestern University

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