HORAI NAOTO
Organization
Center for Advanced Medical Open Innovation Professor
Title
Professor
Contact information
Profile
がん免疫共同研究のマネジメント
創薬に関する教育
ARO橋渡研究推進部門との連携
External link
Degree
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Ph.D.
Research History
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株式会社 新日本科学
株式会社 新日本科学
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岐阜薬科大学 特任准教授
Research Interests・Research Keywords
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Research theme：Drug development and research in cancer immunology
Keyword：non-clinical studies, cancer immunology
Research period： 2019.4 - 2022.3
Papers
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Healing of two-wall intra-bony defects treated with a novel EMD-liquid-A pre-clinical study in monkeys. Invited Reviewed International journal
Shirakata Y, Miron RJ, Shinohara Y, Nakamura T, Sena K, Horai N, Bosshardt DD, Noguchi K, Sculean A
J Clin Periodontol. 2017.12
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Movement of retinal vessels toward the optic nerve head after increasing intraocular pressure in monkey eyes with experimental glaucoma. Invited Reviewed International journal
Kuroda A, Enomoto N, Ishida K, Shimazawa M, Noguchi T, Horai N, Onoe H, Hara H, Tomita G
Exp Eye Res. 2017.9
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Relationship between Elevated Intraocular Pressure and Divided Peripapillary Sector Retinal Nerve Fiber Layer Thickness in a Cynomolgus Monkey Laser-Induced Ocular Hypertension Model. Invited Reviewed International journal
Noguchi T, Shimazawa M, Hamaguchi K, Araki T, Horai N, Hara H
Ophthalmic Res. 2017.6
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Effects of EMD liquid (Osteogain) on periodontal healing in class III furcation defects in monkeys. Invited Reviewed International journal
Shirakata Y, Miron RJ, Nakamura T, Sena K, Shinohara Y, Horai N, Bosshardt DD, Noguchi K, Sculean A
J Clin Periodontol. 2017.3
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Chemically Modified Interleukin-6 Aptamer Inhibits Development of Collagen-Induced Arthritis in Cynomolgus Monkeys. Invited Reviewed International journal
Hirota M, Murakami I, Ishikawa Y, Suzuki T, Sumida S, Ibaragi S, Kasai H, Horai N, Drolet DW, Gupta S, Janjic N, Schneider DJ
Nucleic Acid Ther. 2016.2
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Joint Degradation in a Monkey Model of Collagen-Induced Arthritis: Role of Cathepsin K Based on Biochemical Markers and Histological Evaluation. Invited Reviewed International journal
Tanaka M, Yamada H, Nishikawa S, Mori H, Ochi Y, Horai N, Li M, Amizuka N
Int J Rheumatol. 2016.1
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Muscle wasting associated with pathologic change is a risk factor for the exacerbation of joint swelling in collagen-induced arthritis in cynomolgus monkeys. Invited Reviewed International journal
Horai N, Nagaoka T, Higuchi I, Kasai H, Yoshioka T, Umekita Y, Fukuzaki K, Nagata R, Miyata A, Abeyama K
BMC Musculoskelet Disord. 2013.7
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Tocilizumab, a humanized anti-interleukin-6 receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-induced hepcidin production. Invited Reviewed International journal
Hashizume M, Uchiyama Y, Horai N, Tomosugi N, Mihara M
Rheumatol Int. 2010.5
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Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis. Invited Reviewed International journal
Hamada T, Torikai M, Kuwazuru A, Tanaka M, Horai N, Fukuda T, Yamada S, Nagayama S, Hashiguchi K, Sunahara N, Fukuzaki K, Nagata R, Komiya S, Maruyama I, Fukuda T, Abeyama K
Arthritis Rheum. 2008.9
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Dysregulation of trace element composition in ovariectomized cynomolgus monkey bones. Invited Reviewed International journal
Yamada G, Nakamura S, Fukuzaki K, Izumi H, Horai N, Nagata R, Minami T, Tohno Y, Suzuki K, Haraguchi R, Miyado K, Toyoda T, Izpisua-Belmonte JC, Maruyama I, Kitajima I
Cell Mol Biol. 1998.12
Presentations
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大動物における各種イメージングを用いた非臨床研究への応用、安全性評価研究会；大阪，2018（招待講演）
寳来直人
2020.1
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成獣/幼若‐成人/小児のトランスレーショナル骨成長、第42回 日本毒性学会学術年回；金沢，2015（シンポジウム）
寳来直人
2020.1
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サルを用いた疾患病態解明および創薬研究の最前線、第90回 日本薬理学会年会；長崎，2018（シンポジウム）
寳来直人
2020.1
MISC
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非臨床試験における各種イメージングモダリティの有用性
寳来直人、杉山大介
毒性質問箱 第21号 2019.11
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DXA及びMRIを用いた霊長類における筋肉量測定
寳来 直人, 角崎 英志
日薬理誌 2018.9
Professional Memberships
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日本毒性学会、日本薬理学会
Research Projects
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がん免疫に関する共同研究
2019.5
Authorship：Principal investigator
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がん免疫に関する共同研究
2019.4 - 2021.3
共同研究
Authorship：Principal investigator Grant type：Other funds from industry-academia collaboration
Class subject
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Japan medical innovation program（JMIP） 分担
2019.10 - 2020.3 Second semester
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Translational Science & Medicine Training Program（TSMTP） 分担
2019.4 - 2019.9 First semester
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「医療イノベーション-未来の医療を一緒に作ろう-」 分担
2019.4 - 2019.9 First semester
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次世代アントレプレナー育成プログラム「EDGE-NEXT」 分担
2019.4 - 2019.9 First semester
Media Coverage
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（４月18日 28面） 九州大学は同大の先端融合医療創成センターに新日本科学との共同研究部門を設置した。がん免疫に関する橋渡し研究を推進する。 Newspaper, magazine
日刊工業新聞 2019.5