The role of cullin 5-containing ubiquitin ligases. Reviewed International journal

Okumura F, Joo-Okumura A, Nakatsukasa K, Kamura T

Cell Division   2016.3

Regulation of cellular functions by Elongin BC based E3 ubiquitin ligase. Reviewed

Okumura F, Okumura A, Nakatsukasa K, Kamura T

Seikagaku   85 ( 2 )   76 - 88   2013.3

Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation. Reviewed International journal

Okumura F, Okumura AJ, Uematsu K, Hatakeyama S, Zhang DE, Kamura T

Journal of Biological Chemistry   288 ( 4 )   2839 - 2847   2013.1

PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Reviewed International journal

Shia WJ, Okumura Joo A, Yan M, Sarkeshik A, Lo MC, Matsuura S, Zhao X, Nimer SD, Yates JR, Zhang DE

Blood   119 ( 21 )   4953 - 4962   2012.5

TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells. Reviewed International journal

Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S

Biochimica et Biophysica Acta   1813 ( 10 )   1784 - 1792   2011.10

The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Reviewed International journal

Suizu F, Hiramuki Y, Okumura F, Matsuda M, Okumura Joo A, Hirata N, Narita M, Kohno T, Yokota J, Bohgaki M, Obuse C, Hatakeyama S, Obata T, Noguchi M

Dev Cell   17 ( 6 )   800 - 810   2009.12

AML1/ETO Oncoprotein is directed to AML1 binding regions and co-localizes with AML1 and HEB on its targets. Reviewed International journal

Gardini A, Cesaroni M, Luzi L, Okumura Joo A, Biggs JR, Minardi SP, Venturini E, Zhang DE, Pelicci PG, Alcalay M

PLoS Genet   4 ( 11 )   e1000275   2008.11

Inability of RUNX1/AML1 to breach AML1-ETO block of embryonic stem cell definitive hematopoiesis. Invited Reviewed International journal

Peterson LF, Lo MC, Okumura Joo A, and Zhang DE

Blood Cells Mol Dis   39 ( 3 )   321 - 328   2007.11

Expression of AML/Runx and ETO/MTG family members during hematopoietic differentiation of embryonic stem cells. Reviewed International journal

Okumura Joo A, Peterson LF, Lo MC, Zhang DE

Exp Hematol   35 ( 6 )   978 - 998   2007.6

Involvement of a Novel Q-SNARE, D12, in Quality Control of the Endomembrane System. Reviewed International journal

Okumura Joo A, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, Nagao K, Nishikawa M, Yoshimura A, Wada I

J Biol Chem   281 ( 7 )   4495 - 4506   2006.2

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. Reviewed International journal

Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A

J Exp Med   199 ( 2 )   1701 - 1707   2004.6

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression. Reviewed International journal

Joo A, Aburatani H, Morii E, Iba H, Yoshimura A

Oncogene   23 ( 3 )   726 - 734   2004.1

STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. Reviewed International journal

Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A

J Biol Chem   278 ( 13 )   11182 - 11189   2003.3

CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation. Reviewed International journal

Endo T, Sasaki A, Minoguchi M, Joo A, Yoshimura A

J.Biochem (Tokyo)   133 ( 1 )   109 - 113   2003.1

Control mechanism of JAK/STAT signal :transduction pathway. Reviewed International journal

Yamada S, Shiono S, Joo A, Yoshimura A

FEBS Lett   534 ( 1-3 )   190 - 196   2003.1

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): implications for schizophrenia. Reviewed International journal

Tani A, Kikuta R, Itoh K, Joo A, Shibata H, Ninomiya H, Tashiro N, and Fukumaki Y

Schizophr Res   58 ( 1 )   83 - 86   2002.11

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia. Reviewed International journal

Shibata H, Joo A, Fujii Y, Tani A, Makino C, Hirata N, Kikuta R, Ninomuya H, Tashiro N, Fukumaki Y

Psychiatr Genet   11 ( 3 )   139 - 144   2001.9

Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): analysis of association with schizophrenia. Reviewed International journal

Joo A, Shibata H, Ninomiya H, Kawasaki H, Tashiro N, Fukumaki Y

Mol Psychiatry   2   186 - 192   2001.3

Regulation of protein translation by ISG15-modified PKR.

2013.12 

Activation of double-stranded RNA-activated protein kinase (PKR) by interferon stimulated gene 15 (ISG15) modification down-regulates cap structuredependent translation.

Fumihiko Okumura, Akiko Okumura, Shigetsugu Hatakeyama, Zhang Dong-Er, Takumi Kamura

2012.12 

TRIM8 regulates Nanog via Hsp90β-medicated nuclear translocation of STAT3 in embryonic stem cells.

奥村 文彦、奥村 晶子、松本 雅記、中山 敬一、嘉村 巧、畠山 鎮次

第34回日本分子生物学会年会  2011.12 

ユビキチンリガーゼASB7によるDDA3の発現制御は、適切な紡錘体形成と染色体分配に必要である Invited

奥村 文彦、植松 桂司、外海 駿輔、奥村(城尾) 晶子、Alemayehu Dawit、錦見 昭彦、福井 宣規、中務 邦雄、嘉村 巧

2017.12 

ユビキチンリガーゼASB7 によるDDA3 の発現制御 は適切な紡錘体形成と染色体分配に必要である

奥村 文彦、植松 桂司、外海 駿輔、奥村（城尾） 晶子、Dawit Hailu Alemayehu、錦見 昭彦、福井 宣規、中務 邦雄、嘉村 巧

日本薬学会第138年会  2018.3 

ユビキチンリガーゼSPSB4はEphB2を介した細胞間反発運動を抑制する

奥村 文彦、奥村（城尾） 晶子、小原 圭介、Alexander Petersen、錦見 昭彦、福井 宣規、 中務 邦雄、嘉村 巧

第41回日本分子生物学会年会  2018.11 

ガン発症におけるRUNXタンパク質の機能解析

2005.4 - 2020.3

九州大学(日本) 

STAT3と共役して形質転換を誘導する新規増殖因子granulinの機能解析

2005 - 2006

日本学術振興会  特別研究員

転写因子 AML１ の造血系における機能および白血病誘発機序の解明

Grant number：平成16年度  2005

科学研究費助成事業  持田記念医学薬学振興財団　留学補助金

癌細胞におけるSTAT3の活性化機構と共役因子の同定

2003 - 2004

日本学術振興会  特別研究員