Updated on 2026/06/25

Information

 

写真a

 
KAWANO TAKAHITO
 
Organization
Faculty of Medical Sciences Department of Advanced Medical Initiatives Associate Professor
Center for Advanced Medical Open Innovation （Concurrent）
Title
Associate Professor
External link

Research Areas

  • Life Science / Biomaterials

Degree

  • 博士（工学） （ 2008.3 Kyushu University ）

Research History

  •  Faculty of Medical Sciences Department of Advanced Medical Initiatives  Associate Professor 

    2026.2 - Present

  • Kyushu University 九州大学先端医療オープンイノベーションセンター Specially Appointed Lecturer 

    2023.10 - 2026.1

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    Country：Japan

  • 日本レドックス株式会社

    2023.4 - 2023.9

  • Kyushu University 先端医療オープンイノベーションセンター Specially Appointed Lecturer 

    2020.4 - 2023.3

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    Country：Japan

  • Kyushu University 先端医療イノベーションセンター Specially Appointed Assistant Professor 

    2017.4 - 2020.3

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    Country：Japan

  • Kyushu University 先端融合医療レドックスナビ研究拠点 Specially Appointed Assistant Professor 

    2012.4 - 2017.4

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    Country：Japan

  • Tohoku University WPI-AIMR Research Assistant 

    2010.1 - 2012.3

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    Country：Japan

  • Kyushu University 先導物質化学研究所 part-time researcher 

    2008.4 - 2010.1

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    Country：Japan

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Education

  • Kyushu University   システム生命科学府   システム生命科学専攻

    2005.4 - 2008.3

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    Country：Japan

  • Nagasaki University   生産科学研究科   物質工学専攻

    2003.4 - 2005.3

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    Country：Japan

  • Nagasaki University   工学部   応用化学科

    2000.4 - 2003.3

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    Country：Japan

Research Interests・Research Keywords

  • Research theme： Inflammation control with nanopharmaceuticals

    Keyword： 炎症、ナノキャリア、サイトカイン

    Research period： 2026.2 - Present

  • Research theme： Development of an early cancer diagnosis system

    Keyword： リキッドバイオプシー、バイオマーカー

    Research period： 2026.2 - Present

Papers

  • Distinct Composition-dependent Biodistribution Patterns of Phospholipid Liposomes(タイトル和訳中) Reviewed

    Kawano Takahito, Kang Jeong-Hun, Murata Masaharu

    Journal of Oleo Science   75 ( 1 )   45 - 50   2026.1   （ ISSN:1345-8957 ）

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    Language：English   Publisher：(公社)日本油化学会  

  • Phospholipids and their metabolites as diagnostic biomarkers of human diseases. Reviewed International journal

    Jeong-Hun Kang, Riki Toita, Takahito Kawano, Masaharu Murata, Arihiro Kano

    Progress in lipid research   99   101340 - 101340   2025.7   （ ISSN:0163-7827 eISSN:1873-2194 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Progress in Lipid Research  

    Phospholipids that occur predominantly in the plasma membrane of mammalian cells are phosphatidylcholine (PC), phosphatidylserine (PS), phosphatidylethanolamine (PE), sphingomyelin (SM), and phosphatidylinositol (or phosphoinositide; PI). These membrane phospholipids are a promising source of disease-related biomarkers. Phospholipids and their metabolites are altered by the type of disease or disease progression. Metabolomics has shown that increased or decreased levels of altered phospholipids and their metabolites can be useful indicators for the diagnosis of various human diseases. In this review, we discuss the utility of the five major membrane phospholipids (PC, PS, PE, and SM, and PI) and their metabolites as diagnostic biomarkers of human diseases.

    DOI： 10.1016/j.plipres.2025.101340

    Web of Science

    Scopus

    PubMed

  • Evaluation of the redox alteration in Duchenne muscular dystrophy model mice using in vivo DNP-MRI Reviewed

    Hinako Eto, Masaharu Murata, Takahito Kawano, Yoko Tachibana, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo, Fuminori Hyodo

    npj Imaging   2 ( 1 )   52   2024.12   （ eISSN:2948-197X ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Duchenne muscular dystrophy (DMD) is a genetic muscular disease and is the most common type of muscular dystrophy in Japan. Noninvasive magnetic resonance imaging (MRI) can be used for follow-up evaluation of myositis and muscular dystrophy, including DMD and inflammation is evaluated based on the increased muscle water as evaluated by T2-weighted MR images. However, in MDM, the redox status has not been evaluated non-invasively during the disease progression. We assessed the inflammation via the redox status in experimental animal disease models using in vivo dynamic nuclear polarization MRI (DNP-MRI) with a redox probe. The current study aimed to evaluate the skeletal muscle of mdx mice, a DMD model, in which muscle fiber necrosis, inflammation, and muscle regeneration were chronically repeated. Results showed that the reduction rate of Carbamoyl-PROXYL (CmP), one of the redox probes, radicals in mdx mice increased compared with that in normal mice. In vitro, more mitochondria or macrophages enhanced the radical form decay reaction by reducing CmP. Due to muscle fiber damage, the mdx mice had a lower mitochondrial concentration in the gastrocnemius muscle than the normal mice. However, the in vivo DNP-MRI results strongly reflected the increased reduction of CmP radicals by macrophages. In conclusion, in vivo DNP-MRI, a noninvasive imaging method is useful for locally evaluating skeletal muscle inflammation.

    DOI： 10.1038/s44303-024-00058-8

    Scopus

    PubMed

    Other Link： https://www.nature.com/articles/s44303-024-00058-8

  • Vascular calcification and cellular signaling pathways as potential therapeutic targets. Reviewed International journal

    Jeong-Hun Kang, Takahito Kawano, Masaharu Murata, Riki Toita

    Life sciences   336   122309 - 122309   2024.1   （ ISSN:0024-3205 eISSN:1879-0631 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Life Sciences  

    Increased vascular calcification (VC) is observed in patients with cardiovascular diseases such as atherosclerosis, diabetes, and chronic kidney disease. VC is divided into three types according to its location: intimal, medial, and valvular. Various cellular signaling pathways are associated with VC, including the Wnt, mitogen-activated protein kinase, phosphatidylinositol-3 kinase/Akt, cyclic nucleotide-dependent protein kinase, protein kinase C, calcium/calmodulin-dependent kinase II, adenosine monophosphate-activated protein kinase/mammalian target of rapamycin, Ras homologous GTPase, apoptosis, Notch, and cytokine signaling pathways. In this review, we discuss the literature concerning the key cellular signaling pathways associated with VC and their role as potential therapeutic targets. Inhibitors to these pathways represent good candidates for use as potential therapeutic agents for the prevention and treatment of VC.

    DOI： 10.1016/j.lfs.2023.122309

    Web of Science

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    PubMed

  • ヘモグロビン分析のための包括的画像処理法および腹腔鏡システム統合への応用(Comprehensive Image-processing Technique for Hemoglobin Analysis and Applications in Laparoscopic System Integration) Reviewed

    Chiba Toru, Obara Yoshimi, Oguri Susumu, Kawano Takahito, Akahoshi Tomohiko, Murata Masaharu

    Advanced Biomedical Engineering   13   389 - 400   2024

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    Language：English   Publisher：(公社)日本生体医工学会  

    血液濃度と酸素飽和度を測定するため、3バンド光学フィルターを用いたスペクトル画像法に腹腔鏡を組み合わせた。フィルターにて、血液濃度と酸素飽和度の波長を赤-緑-青色のバンドに相関させ、視覚化した。マウスを用いてテストした結果、アーチファクトも遅延もなく、リアルタイムの情報を得ることができた。

  • Comprehensive Image-processing Technique for Hemoglobin Analysis and Applications in Laparoscopic System Integration Reviewed

    CHIBA Toru, OBARA Yoshimi, OGURI Susumu, KAWANO Takahito, AKAHOSHI Tomohiko, MURATA Masaharu

    Advanced Biomedical Engineering   13 ( 0 )   389 - 400   2024   （ ISSN:2187-5219 eISSN:21875219 ）

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    Language：English   Publisher：Japanese Society for Medical and Biological Engineering  

    <p>Surgical cameras and endoscopes provide important imaging information about a patient's anatomy and pathology, but most of the data are limited to 2D textured representations of visible tissue surfaces. Conversely, research is progressing in the information acquisition field by using spectrum data to obtain more detailed disease diagnostic support information. Spectroscopic information reflects the chemical and physical information of substances. Research is expanding from conventional single-point spectroscopic information to acquisition of two-dimensional spectroscopic information, called hyperspectral data. However, this type of information typically takes a relatively long time to acquire and analyze, which has limited its practical use. Particularly, compensation for the continuous motions of the camera and tissue occurring during acquisition of numerous images as well as the analysis time slow delivery of real-time information. Due to these disadvantages, the use of analyzed hyperspectral data information in medicine has been limited to the research stage. This study aimed to use this system to visualize blood phantoms and biological information from small animals. We developed a 3-band spectral imaging method for measuring relative blood concentration and oxygen saturation, and modified white light images. Real-time information display is possible by limiting the target information and speeding up image acquisition and processing. We also developed an existing red-green-blue (RGB) wavelength-band digital imaging system, in which an optical filter is used to limit the wavelength range to effectively capture the spectral changes associated with oxygen saturation and concentration. Since the three-wavelength information is in the wavelength range of the RGB channels of the image sensor, single-frame data capture was achieved. An analytical method for 3-band spectral data was also developed, which contributed to fast image processing. Further development of this technology can eliminate the disadvantages associated with conventional spectroscopic imaging and analysis. Consequently, we expect that it will contribute to practical use of spectral information in the medical field. The method developed in this study can be applied to general purpose cameras and is highly practical as a display technology for diagnostic support information.</p>

    DOI： 10.14326/abe.13.389

    Web of Science

    Scopus

    CiNii Research

  • Protein Kinase C (PKC) Isozymes as Diagnostic and Prognostic Biomarkers and Therapeutic Targets for Cancer Reviewed

    Takahito Kawano, Junichi Inokuchi, Masatoshi Eto, Masaharu Murata, Jeong-Hun Kang

    Cancers   14 ( 21 )   5425 - 5425   2022.11   （ ISSN:2072-6694 eISSN:2072-6694 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：MDPI AG  

    Protein kinase C (PKC) is a large family of calcium- and phospholipid-dependent serine/threonine kinases that consists of at least 11 isozymes. Based on their structural characteristics and mode of activation, the PKC family is classified into three subfamilies: conventional or classic (cPKCs; α, βI, βII, and γ), novel or non-classic (nPKCs; δ, ε, η, and θ), and atypical (aPKCs; ζ, ι, and λ) (PKCλ is the mouse homolog of PKCι) PKC isozymes. PKC isozymes play important roles in proliferation, differentiation, survival, migration, invasion, apoptosis, and anticancer drug resistance in cancer cells. Several studies have shown a positive relationship between PKC isozymes and poor disease-free survival, poor survival following anticancer drug treatment, and increased recurrence. Furthermore, a higher level of PKC activation has been reported in cancer tissues compared to that in normal tissues. These data suggest that PKC isozymes represent potential diagnostic and prognostic biomarkers and therapeutic targets for cancer. This review summarizes the current knowledge and discusses the potential of PKC isozymes as biomarkers in the diagnosis, prognosis, and treatment of cancers.

    DOI： 10.3390/cancers14215425

    Web of Science

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    PubMed

  • Activated protein kinase C-alpha as a simple test for urothelial cancer screening. Reviewed

    Inokuchi, J; Murata, M; Kawano, T; Kang, JH; Kinoshita, F; Matsumoto, T; Monji, K; Kashiwagi, E; Takeuchi, A; Shiota, M; Eto, M

    JOURNAL OF CLINICAL ONCOLOGY   40 ( 16 )   E16552 - E16552   2022.6   （ ISSN:0732-183X eISSN:1527-7755 ）

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Books

  • Non-viral Gene Therapy

    Kawano, T., Niidome, T.（Role：Joint authorEvaluation by southern blot hybridization of DNA administered with a gene carrier to organs）

Presentations

MISC

  • アポトーシスメカニズムを利用したリポソーム組成物及び炎症性疾患用治療剤

    姜貞勲, 河野喬仁, 村田正治, 戸井田力

    日本分子生物学会年会プログラム・要旨集(Web)   47th   2024

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  • Development of macrophage phenotype-regulated liposomes and suppression of cytokine storm

    河野喬仁, 戸井田力, 楢原佐由子, 兵藤文紀, 赤星朋比古, KANG J-H, 村田正治

    日本DDS学会学術集会プログラム予稿集   40th (CD-ROM)   2024

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  • The utility of activated PKC-alpha as a novel urine biomarker for urothelial cancer regardless of tumor grade

    猪口淳一, 河野喬仁, 村田正治, 姜貞勲, 後藤駿介, 松元崇, 門司恵介, 塩田真己, 江藤正俊, 江藤正俊

    日本泌尿器科学会総会(Web)   110th   2023

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  • Application of apoptotic mechanism-based nanomedicine to prevention and treatment of inflammatory diseases

    KANG Jeong-Hun, 河野喬仁, 村田正治, 戸井田力

    日本分子生物学会年会プログラム・要旨集(Web)   46th   2023

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  • PSリポソームによるマクロファージ機能変換と炎症性疾患の治療

    河野喬仁, 戸井田力, 楢原佐由子, 兵藤文紀, 赤星朋比古, 姜貞勲, 村田正治

    日本DDS学会学術集会プログラム予稿集   39th   2023

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  • In vitro reaction analysis method using DNP-MRI equipped with an incubating environment

    江藤比奈子, 長沼辰弥, 田村千尋, 河野喬仁, 水田幸恵, 兵藤文紀, 兵藤文紀, 村田正治

    電子スピンサイエンス学会年会講演要旨集   61st (CD-ROM)   2022

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  • Web Dictionary of Medical Engineering, Volume.1 Reviewed

    相川 慎也, 芦原 貴司, 天野 晃, 有末 伊織, 安藤 譲二, 伊井 仁志, 出江 紳一, 伊東 保志, 稲田 慎, 井上 雅仁, 今井 健, 岩下 篤司, 上村 和紀, 内野 詠一郎, 宇野 友貴, 江村 拓人, 大内田 研宙, 大城 理, 太田 淳, 太田 岳, 大谷 智仁, 大家 渓, 岡 崇史, 岡崎 哲三, 岡本 和也, 岡山 慶太, 小倉 正恒, 小山 大介, 海住 太郎, 片山 統裕, 勝田 稔三, 加藤 雄樹, 加納 慎一郎, 鎌倉 令, 亀田 成司, 河添 悦昌, 河野 喬仁, 紀ノ定 保臣, 木村 映善, 木村 真之, 粂 直人, 藏富 壮留, 黒田 知宏, 小島 諒介, 小西 有人, 此内 緑, 小林 哲生, 坂田 泰史, 朔 啓太, 篠原 一彦, 白記 達也, 代田 悠一郎, 杉山 治, 鈴木 隆文, 鈴木 英夫, 外海 洋平, 高橋 宏和, 田代 洋行, 田村 寛, 寺澤 靖雄, 飛松 省三, 戸伏 倫之, 中沢 一雄, 中村 大輔, 西川 拓也, 西本 伸志, 野村 泰伸, 羽山 陽介, 原口 亮, 日比野 浩, 平木 秀輔, 平野 諒司, 深山 理, 稲岡 秀検, 堀江 亮太, 松村 泰志, 松本 繁巳, 溝手 勇, 向井 正和, 牟田口 淳, 門司 恵介, 百瀬 桂子, 八木 哲也, 柳原 一照, 山口 陽平, 山田 直生, 山本 希美子, 湯本 真人, 横田 慎一郎, 吉原 博幸, 江藤 正俊, 川田 徹, 紀ノ岡 正博, 杉町 勝, 中島 一樹, 成瀬 恵治, 橋爪 誠, 平田 雅之, 福岡 豊, 不二門 尚, 村田 正治, 守本 祐司, 横澤 宏一, 吉田 正樹, 和田 成生

    Transactions of Japanese Society for Medical and Biological Engineering   Dictionary.1   1 - 603   2022   （ ISSN:1347-443X eISSN:1881-4379 ）

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    Language：Japanese   Publisher：Japanese Society for Medical and Biological Engineering  

    DOI： 10.11239/jsmbe.dictionary.1.1

    CiNii Research

    Other Link： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H04496/

  • Application of a protein kinase Cα (PKCα)-specific peptide substrate to development of cancer diagnostic tool

    KANG Jeong-Hun, 河野喬仁, 村田正治, 猪口淳一, 江藤正俊, 江藤正俊

    日本分子生物学会年会プログラム・要旨集(Web)   45th   2022

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Industrial property rights

Patent   Number of applications: 5   Number of registrations: 0
Utility model   Number of applications: 0   Number of registrations: 0
Design   Number of applications: 0   Number of registrations: 0
Trademark   Number of applications: 0   Number of registrations: 0

Professional Memberships

  • 日本DDS学会

Research Projects

  • Ultra-sensitive imaging and therapy of pancreatic cancer using multifunctional nanocarriers

    Grant number：25K03467  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    村田 正治, 大内田 研宙, 河野 喬仁

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    Grant type：Scientific research funding

    膵がんは極めて予後不良であり、がん免疫療法が保険収載された現在においても、早期発見こそが予後を改善する最も有効な手段に変わりはない。本研究では独自のプロテインナノケージ技術を用いて、膵がんの超高感度MRイメージングとそのがん微小環境を形成するマクロファージ（TAM）を標的とする薬物輸送を同時に達成する診断・治療システムを開発する。本研究は医工連携のもと、ナノカプセル型MRI造影剤の「超高感度化」、「膵がん特異性」、そして「治療薬の内包と放出」を実現することで飛躍的な高機能化を実現する。

    CiNii Research

  • Ultrasensitive imaging of pancreatic cancer using multimodal nanocarriers and regulation of the cancer microenvironment

    Grant number：23K25209  2024.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (B)

    MURATA MASAHARU

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    Grant type：Scientific research funding

    Pancreatic cancer has an extremely poor prognosis, and even now that cancer immunotherapy is covered by insurance, early detection remains the most effective means to improve prognosis. In this study, we aimed to develop a diagnostic and therapeutic system that simultaneously achieves ultra-sensitive MR imaging of pancreatic cancer and drug delivery targeting macrophages that form the cancer microenvironment (tumor-associated macrophages, TAM) using nanotechnology.

    CiNii Research

  • Development and investigation of clinical utility of simple sensor device for novel urinary cancer biomarkers detection

    Grant number：23K11898  2023.4 - 2026.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    猪口 淳一, 村田 正治, 姜 貞勲, 河野 喬仁, 松元 崇

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    Grant type：Scientific research funding

    尿路上皮癌は尿路上皮から発生する悪性腫瘍で、有用な血液腫瘍マーカーがない一方で、尿を用いたスクリーニング検査法の開発が行われてきました。しかし、その多くは偽陽性率が高く、特異度が非常に高い尿細胞診以外は実臨床においてあまり利用されていません。我々はこれまでに、感度、特異度が高い尿路上皮癌に対する新たなバイオマーカーを開発しました。本研究では、この新規バイオマーカーを検出する安価で簡便な検査法を開発し、その有効性を評価します。

    CiNii Research

  • Development of cell signal-responsive contrast agent for diagnosis of NASH

    Grant number：21K18325  2021.7 - 2024.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Challenging Research (Pioneering)

    Murata Masaharu

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    Grant type：Scientific research funding

    In this study, we designed and constructed a functionalized contrast agent that specifically reacts to inflammasomes and can modify its signal according to its activity. Protein-based nanostructures were used as a platform. In preliminary experiments, the nanostructures were extremely stable in blood and remained stable for at least one week without being degraded by blood enzymes. Furthermore, after administration to mice, various biochemical parameters were measured by the JSCC standard method, and no acute toxicity due to the nanostructures was observed. In addition, the structural changes of the nanostructures allowed quantitative and real-time observation of inflammasomes as an intracellular inflammatory response.

    CiNii Research

  • Measurement of molecular pathogenesis of pancreatic cancer using cell function detection MRI contrast agents

    Grant number：21K12685  2021 - 2023

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    Kawano Takahito

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    Authorship：Principal investigator  Grant type：Scientific research funding

    While MRI has the advantages of spatial resolution and non-invasiveness, it has a disadvantage in terms of sensitivity to detect disease sites. In this study, we aimed to improve the accuracy and sensitivity of MRI diagnosis and to develop a new highly sensitive MRI nanocontrast agent that enables functional and metabolic imaging of pathological conditions, rather than simply using MRI as a morphological diagnostic method. Using dynamic nuclear polarization (DNP) based on metabolic imaging, we confirmed whether pancreatic cancer can be detected by DNP-MRI imaging of pancreatic cancer mice. The results showed that nitroxyl radical signals and attenuation were predominant around the pancreatic cancer tissue, and metabolic imaging in pancreatic cancer was possible.

    CiNii Research

  • 癌微小環境を可視化する高感度MRIナノ造影剤の開発

    Grant number：18K12079  2018 - 2020

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 癌特異的タンパク質ナノ造影剤による病態の機能イメージング

    Grant number：15K16333  2015 - 2017

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • タンパク質ナノカプセルを用いたMRIナノ造影剤の構築と機能診断

    Grant number：25750176  2013 - 2015

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Young Scientists (B)

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    Authorship：Principal investigator  Grant type：Scientific research funding

  • 腫瘤径5mmの超早期膵がんの描出を可能にするインテリジェント型機能化造影剤

    Grant number：19H04470 

    河野 喬仁, 大内田 研宙, 村田 正治

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    Grant type：Scientific research funding

    膵がんは極めて不良であり、早期発見こそが予後を改善する唯一の手段となっている。MRIは組織分解能に優れ、また様々な角度から撮像できることから膵がんの画像診断法として用いられているが、80％以上の5年生存率が期待できる腫瘍径1cm以下のがん部を描出するには、感度も特異性も決定的に不足している。
    本研究では独自のプロテインケージ技術を用いて、直径12nmのナノカプセル型機能化造影剤を分子設計する。そのサイズと剛直性、表面へのアンテナ分子の呈示（分子標的化）、そして細胞シグナルによる構造変化などを制御することによって、膵がんに対する「超高感度化」、「膵がん特異性」、そして「疾患応答性」を付与する。

    CiNii Research

  • 尿中PKCαを標的とした新規尿路上皮がん診断システムの開発

    Grant number：19K09692 

    姜 貞勲, 今田 憲二郎, 河野 喬仁, 猪口 淳一, 村田 正治

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    Grant type：Scientific research funding

    尿路上皮癌は尿路上皮から発生する悪性腫瘍で、有用な血液腫瘍マーカーがない一方で、尿を用いたスクリーニング検査法の開発が行われてきました。しかし、その多くは偽陽性率が高く、特異度が非常に高い尿細胞診以外は実臨床においてあまり利用されていません。そこで、本研究ではより感度、特異度が高く、かつ簡便な尿路上皮癌に対する検査法として、新たなバイオマーカーを標的として測定法、診断システムの開発を行い、さらに臨床サンプルを用いてこれら診断システムの有効性を評価します。

    CiNii Research

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