Updated on 2024/11/28

Information

 

写真a

 
OUSAKA NAOKI
 
Organization
Research Center for Negative Emissions Technologies Ubiquitous CO2 Research Division Associate Professor
Title
Associate Professor
Contact information
メールアドレス
Tel
0928026871

Degree

  • Doctor of Engineering

Papers

  • Redox-triggered Reversible Switching between Dynamic and Quasi-static α-Helical Peptides. Reviewed International coauthorship International journal

    Ousaka N, MacLachlan MJ, Akine S

    Chemistry (Weinheim an der Bergstrasse, Germany)   30 ( 56 )   e202402704   2024.7   ISSN:0947-6539 eISSN:1521-3765

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    Authorship:Lead author, Corresponding author   Language:English   Publishing type:Research paper (scientific journal)   Publisher:Chemistry - A European Journal  

    We report the reversible transformation between a singly stapled dynamic α-helical peptide and a doubly stapled quasi-static one through redox-triggered dithiol/disulfide conversions of a stapling moiety. This process allows the rate of interconversion between the right-handed (P) and left-handed (M) α-helices to be altered by a factor of approximately 103 before and after the transformation. An as-obtained doubly stapled α-helical peptide, which is composed of an achiral peptide having an l-valine carboxylic acid residue at the C-terminus, a disulfide-based reversible staple, and a biphenyl-based fixed staple, adopts an (M)-rich form as a kinetically trapped state. The (M)-rich helix was subsequently transformed into the thermodynamically stable (P)-rich form in 1,1,2,2-tetrachloroethane with the half-life time (t1/2) of approximately 44 days at 25 °C. Reduction of the doubly stapled peptide with tri-n-butylphosphine in tetrahydrofuran/water (10/1, v/v) produced the corresponding singly stapled dynamic α-helical peptide bearing two thiol groups at the side chains, which underwent solvent-induced reversible helicity inversion. The resulting dithiol of the singly stapled peptide could be reoxidized to form the original doubly stapled form using 4,4’-dithiodipyridine. Furthermore, the P/M interconversion of a doubly stapled peptide with two flexible hydrocarbon-based staples is considerably more rapid than that with more rigid staples.

    DOI: 10.1002/chem.202402704

    Web of Science

    Scopus

    PubMed

  • Separation of enantiomers of chiral fullerene derivatives through enantioselective encapsulation within an adaptable helical cavity of syndiotactic poly(methyl methacrylate) with helicity memory Reviewed

    Daisuke Taura, Akiko Minami, Fumihiko Mamiya, Naoki Ousaka, Kenichiro Itami, Eiji Yashima

    Chirality   36 ( 4 )   2024.4

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chir.23663

  • Stapling strategy for slowing helicity interconversion of α-helical peptides and isolating chiral auxiliary-free one-handed forms Reviewed

    14 ( 1 )   6834   2023.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    Abstract

    In nature, α-helical peptides adopt right-handed conformations that are dictated by L-amino acids. Isolating one-handed α-helical peptides composed of only achiral components remains a significant challenge. Here, this goal is achieved by optical resolution of the corresponding racemic (quasi-)static α-helical peptide with double stapling, which effectively freezes the interconversion between the right-handed (P)- and left-handed (M)-α-helices. An as-obtained doubly stapled analogue having an unprotected L-valine residue at the C-terminus transforms from a kinetically trapped (M)-α-helix to a thermodynamically stable (P)-α-helix upon heating. In contrast, the corresponding singly stapled α-helical peptide undergoes an acid/base-triggered and solvent-induced reversible inversion of its preferred helicity within minutes. The interconversion rates of the singly and doubly stapled α-helical peptide foldamers are approximately 106 and 1012 times slower, respectively, than that of a non-stapled dynamic helical peptide. Therefore, the enantiopure doubly-stapled (quasi-)static α-helical peptide would retain its optical activity for several years at 25 °C.

    DOI: 10.1038/s41467-023-42493-y

  • Supramolecular Helical Assemblies of Dirhodium(II) Paddlewheels with 1,4-Diazabicyclo[2.2.2]octane: A Remarkable Substituent Effect on the Helical Sense Preference and Amplification of the Helical Handedness Excess of Metallo-Supramolecular Helical Polymers Reviewed

    Shogo Okuda, Naoki Ousaka, Takuya Iwata, Riku Ishida, Akio Urushima, Nozomu Suzuki, Shusaku Nagano, Tomoyuki Ikai, Eiji Yashima

    Journal of the American Chemical Society   144 ( 6 )   2775 - 2792   2022.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.1c12652

  • Encapsulation of Aromatic Guests in the Bisporphyrin Cavity of a Double-Stranded Spiroborate Helicate: Thermodynamic and Kinetic Studies and the Encapsulation Mechanism Reviewed

    Naoki Ousaka, Shinya Yamamoto, Hiroki Iida, Takuya Iwata, Shingo Ito, Rafael Souza, Yuh Hijikata, Stephan Irle, Eiji Yashima

    The Journal of Organic Chemistry   86 ( 15 )   10501 - 10516   2021.8

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.joc.1c01155

  • Water-Mediated Reversible Control of Three-State Double-Stranded Titanium(IV) Helicates Reviewed

    Naoki Ousaka, Manabu Itakura, Akira Nagasaka, Masaki Ito, Tomonari Hattori, Daisuke Taura, Tomoyuki Ikai, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   143 ( 11 )   4346 - 4358   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.0c13351

  • One-Pot Nonisocyanate Synthesis of Sequence-Controlled Poly(hydroxy urethane)s from a Bis(six-membered cyclic carbonate) and Two Different Diamines Reviewed

    Naoki Ousaka, Takeshi Endo

    MACROMOLECULES   54 ( 5 )   2059 - 2067   2021.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acs.macromol.1c00045

  • Stimuli-responsive Molecular Springs Based on Single-and Multi-stranded Helical Structures Invited Reviewed

    Naoki Ousaka, Eiji Yashima

    CHEMISTRY LETTERS   50 ( 2 )   320 - 330   2021.2

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    Language:English  

    DOI: 10.1246/cl.200737

  • Helix-Sense-Selective Encapsulation of Helical Poly(lactic acid)s within a Helical Cavity of Syndiotactic Poly(methyl methacrylate) with Helicity Memory Reviewed

    Tomoyuki Ikai, Satoshi Kawabata, Fumihiko Mamiya, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   142 ( 52 )   21913 - 21925   2020.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.0c11204

  • Remote-controlled regio- and diastereodifferentiating photodimerization of a dynamic helical peptide-bound 2-substituted anthracene Reviewed

    Daisuke Taura, Akio Urushima, Yusuke Sugioka, Naoki Ousaka, Eiji Yashima

    CHEMICAL COMMUNICATIONS   56 ( 87 )   13433 - 13436   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0cc06164f

  • Chiral Guest-induced Catalytic Deracemization of a Spiroborate-based Double-stranded Helicate Bearing a Bisporphyrin Unit with Acids Reviewed

    Masaki Ito, Tomoyuki Ikai, Shinya Yamamoto, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    CHEMISTRY LETTERS   49 ( 9 )   1030 - 1033   2020.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.200352

  • Inside Back Cover: Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines (Angew. Chem. Int. Ed. 19/2020)

    59 ( 19 )   7620 - 7620   2020.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.202004586

  • Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines

    132 ( 19 )   7548 - 7556   2020.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ange.201916103

  • Enantiodifferentiating Photodimerization of a 2,6-Disubstituted Anthracene Assisted by Supramolecular Double-Helix Formation with Chiral Amines Reviewed

    Akio Urushima, Daisuke Taura, Makoto Tanaka, Naomichi Horimoto, Junki Tanabe, Naoki Ousaka, Tadashi Mori, Eiji Yashima

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   59 ( 19 )   7478 - 7486   2020.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201916103

  • Innenrücktitelbild: Enantiodifferentiating Photodimerization of a 2,6‐Disubstituted Anthracene Assisted by Supramolecular Double‐Helix Formation with Chiral Amines (Angew. Chem. 19/2020)

    132 ( 19 )   7695 - 7695   2020.5

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ange.202004586

  • Complementary double-stranded helical oligomers bearing achiral bifunctional groups that catalyze asymmetric aldol reaction Reviewed

    Daisuke Taura, Kouhei Shimomura, Naoki Ousaka, Eiji Yashima

    CHIRALITY   32 ( 3 )   254 - 264   2020.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/chir.23169

  • Fluorescent molecular spring that visualizes the extension and contraction motions of a double-stranded helicate bearing terminal pyrene units triggered by release and binding of alkali metal ions Reviewed

    Daisuke Taura, Kaori Shimizu, Chiaki Yokota, Riho Ikeda, Yoshimasa Suzuki, Hiroki Iida, Naoki Ousaka, Eiji Yashima

    CHEMICAL COMMUNICATIONS   55 ( 80 )   12084 - 12087   2019.10

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c9cc06126f

  • Water-mediated deracemization of a bisporphyrin helicate assisted by diastereoselective encapsulation of chiral guests Reviewed

    Naoki Ousaka, Shinya Yamamoto, Hiroki Iida, Takuya Iwata, Shingo Ito, Yuh Hijikata, Stephan Irle, Eiji Yashima

    NATURE COMMUNICATIONS   10   2019.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41467-019-09443-z

  • Spiroborate-Based Double-Stranded Helicates: Meso-to-Racemo Isomerization and Ion-Triggered Springlike Motion of the Racemo-Helicate Reviewed

    Naoki Ousaka, Kaori Shimizu, Yoshimasa Suzuki, Takuya Iwata, Manabu Itakura, Daisuke Taura, Hiroki Iida, Yoshio Furusho, Tadashi Mori, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   140 ( 49 )   17027 - 17039   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.8b08268

  • Spiroborate-Based Double-Stranded Helicates: Meso-to-Racemo Isomerization and Ion-Triggered Springlike Motion of the Racemo-Helicate Reviewed

    Naoki Ousaka, Kaori Shimizu, Yoshimasa Suzuki, Takuya Iwata, Manabu Itakura, Daisuke Taura, Hiroki Iida, Yoshio Furusho, Tadashi Mori, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   140 ( 49 )   17027 - 17039   2018.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.8b08268

  • Tug-of-War in a Dynamic Helical Peptide: Solvent-Induced Helix-Helix Transition of a Lactam-Bridged Peptide Composed of Point- and Axial Chiralities Remote from Each Other Reviewed

    Akio Urushima, Naoki Ousaka, Eiji Yashima

    CHEMISTRY-AN ASIAN JOURNAL   13 ( 21 )   3150 - 3154   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201801111

  • Tug-of-War in a Dynamic Helical Peptide: Solvent-Induced Helix-Helix Transition of a Lactam-Bridged Peptide Composed of Point- and Axial Chiralities Remote from Each Other Reviewed

    Akio Urushima, Naoki Ousaka, Eiji Yashima

    CHEMISTRY-AN ASIAN JOURNAL   13 ( 21 )   3150 - 3154   2018.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201801111

  • Allosteric regulation of metal-binding sites inside an optically-active helical foldamer and its tubular assemblies Reviewed

    Satoshi Kawabata, Naoki Ousaka, Eiji Yashima

    CHEMICAL COMMUNICATIONS   54 ( 19 )   2417 - 2420   2018.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c8cc00728d

  • Chirality Control and Its Memory at Microphase-Separated Interface of Self-Assembled Chiral Block Copolymers for Nanostructured Chiral Materials Reviewed

    Ming-Chia Li, Naoki Ousaka, Hsiao-Fang Wang, Eiji Yashima, Rong-Ming Ho

    ACS MACRO LETTERS   6 ( 9 )   980 - 986   2017.9

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    DOI: 10.1021/acsmacrolett.7b00493

  • Chirality Control and Its Memory at Microphase-Separated Interface of Self-Assembled Chiral Block Copolymers for Nanostructured Chiral Materials Reviewed

    Ming-Chia Li, Naoki Ousaka, Hsiao-Fang Wang, Eiji Yashima, Rong-Ming Ho

    ACS MACRO LETTERS   6 ( 9 )   980 - 986   2017.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acsmacrolett.7b00493

  • Alkali Metal Ion-enhanced Threading of a Perylenediimide-ound Polymer Chain through a Double-stranded Spiroborate Helicate with a Bisporphyrin Unit Reviewed

    Naoki Ousaka, Shinya Yamamoto, Naoki Hayashi, Ming-Chia Li, Rong-Ming Ho, Eiji Yashima

    CHEMISTRY LETTERS   46 ( 7 )   970 - 972   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.170271

  • Alkali Metal Ion-enhanced Threading of a Perylenediimide-ound Polymer Chain through a Double-stranded Spiroborate Helicate with a Bisporphyrin Unit Reviewed

    Naoki Ousaka, Shinya Yamamoto, Naoki Hayashi, Ming-Chia Li, Rong-Ming Ho, Eiji Yashima

    CHEMISTRY LETTERS   46 ( 7 )   970 - 972   2017.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1246/cl.170271

  • Development of Helical Oligomers and Polymers Capable of Extension and Contraction Motions Invited Reviewed

    Naoki Ousaka, Eiji Yashima

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   75 ( 5 )   466 - 475   2017.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.5059/yukigoseikyokaishi.75.466

  • Chiral Template-Directed Regio-, Diastereo-, and Enantioselective Photodimerization of an Anthracene Derivative Assisted by Complementary Amidinium-Carboxylate Salt Bridge Formation Reviewed

    Junki Tanabe, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   139 ( 21 )   7388 - 7398   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b03317

  • Development of Helical Oligomers and Polymers Capable of Extension and Contraction Motions Invited Reviewed

    Naoki Ousaka, Eiji Yashima

    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN   75 ( 5 )   466 - 475   2017.5

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.5059/yukigoseikyokaishi.75.466

  • Chiral Template-Directed Regio-, Diastereo-, and Enantioselective Photodimerization of an Anthracene Derivative Assisted by Complementary Amidinium-Carboxylate Salt Bridge Formation Reviewed

    Junki Tanabe, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   139 ( 21 )   7388 - 7398   2017.5

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.7b03317

  • Double-Stranded Helical Oligomers Covalently Bridged by Rotary Cyclic Boronate Esters Reviewed

    Hiroki Iida, Kenji Ohmura, Ryuta Noda, Soichiro Iwahana, Hiroshi Katagiri, Naoki Ousaka, Taku Hayashi, Yuh Hijikata, Stephan Irle, Eiji Yashima

    CHEMISTRY-AN ASIAN JOURNAL   12 ( 8 )   927 - 935   2017.4

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    DOI: 10.1002/asia.201700162

  • Double-Stranded Helical Oligomers Covalently Bridged by Rotary Cyclic Boronate Esters Reviewed

    Hiroki Iida, Kenji Ohmura, Ryuta Noda, Soichiro Iwahana, Hiroshi Katagiri, Naoki Ousaka, Taku Hayashi, Yuh Hijikata, Stephan Irle, Eiji Yashima

    CHEMISTRY-AN ASIAN JOURNAL   12 ( 8 )   927 - 935   2017.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201700162

  • "Helix-in-Helix" Superstructure Formation through Encapsulation of Fullerene-Bound Helical Peptides within a Helical Poly(methyl methacrylate) Cavity Reviewed

    Naoki Ousaka, Fumihiko Mamiya, Yoshiaki Iwata, Katsuyuki Nishimura, Eiji Yashima

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   56 ( 3 )   791 - 795   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201611349

  • "Helix-in-Helix" Superstructure Formation through Encapsulation of Fullerene-Bound Helical Peptides within a Helical Poly(methyl methacrylate) Cavity Reviewed

    Naoki Ousaka, Fumihiko Mamiya, Yoshiaki Iwata, Katsuyuki Nishimura, Eiji Yashima

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   56 ( 3 )   791 - 795   2017.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201611349

  • Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions Reviewed

    Eiji Yashima, Naoki Ousaka, Daisuke Taura, Kouhei Shimomura, Tomoyuki Ikai, Katsuhiro Maeda

    CHEMICAL REVIEWS   116 ( 22 )   13752 - 13990   2016.11

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    Language:English  

    DOI: 10.1021/acs.chemrev.6b00354

  • Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions Reviewed

    Eiji Yashima, Naoki Ousaka, Daisuke Taura, Kouhei Shimomura, Tomoyuki Ikai, Katsuhiro Maeda

    CHEMICAL REVIEWS   116 ( 22 )   13752 - 13990   2016.11

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    DOI: 10.1021/acs.chemrev.6b00354

  • Construction of Covalent Organic Nanotubes by Light-Induced Cross-Linking of Diacetylene-Based Helical Polymers Reviewed

    Kaho Maeda, Liu Hong, Taishi Nishihara, Yusuke Nakanishi, Yuhei Miyauchi, Ryo Kitaura, Naoki Ousaka, Eiji Yashima, Hideto Ito, Kenithiro Itami

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   138 ( 34 )   11001 - 11008   2016.8

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    DOI: 10.1021/jacs.6b05582

  • Construction of Covalent Organic Nanotubes by Light-Induced Cross-Linking of Diacetylene-Based Helical Polymers Reviewed

    Kaho Maeda, Liu Hong, Taishi Nishihara, Yusuke Nakanishi, Yuhei Miyauchi, Ryo Kitaura, Naoki Ousaka, Eiji Yashima, Hideto Ito, Kenithiro Itami

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   138 ( 34 )   11001 - 11008   2016.8

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    DOI: 10.1021/jacs.6b05582

  • Cobalt(II)-Salen-Linked Complementary Double-Stranded Helical Catalysts for Asymmetric Nitro-Aldol Reaction Reviewed

    Daisuke Taura, Shogo Hioki, Junki Tanabe, Naoki Ousaka, Eiji Yashima

    ACS CATALYSIS   6 ( 7 )   4685 - 4689   2016.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/acscatal.6b01627

  • Cobalt(II)-Salen-Linked Complementary Double-Stranded Helical Catalysts for Asymmetric Nitro-Aldol Reaction Reviewed

    Daisuke Taura, Shogo Hioki, Junki Tanabe, Naoki Ousaka, Eiji Yashima

    ACS CATALYSIS   6 ( 7 )   4685 - 4689   2016.7

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    DOI: 10.1021/acscatal.6b01627

  • Allosteric Regulation of Unidirectional Spring-like Motion of Double-Stranded Helicates Reviewed

    Yoshimasa Suzuki, Taiki Nakamura, Hiroki Iida, Naoki Ousaka, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   138 ( 14 )   4852 - 4859   2016.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/jacs.6b00787

  • Allosteric Regulation of Unidirectional Spring-like Motion of Double-Stranded Helicates Reviewed

    Yoshimasa Suzuki, Taiki Nakamura, Hiroki Iida, Naoki Ousaka, Eiji Yashima

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   138 ( 14 )   4852 - 4859   2016.4

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    DOI: 10.1021/jacs.6b00787

  • Control of Conformation and Chirality of Nonplanar pi-Conjugated Diporphyrins Using Substituents and Axial Ligands Reviewed

    Satoru Ito, Satoru Hiroto, Naoki Ousaka, Eiji Yashima, Hiroshi Shinokubo

    CHEMISTRY-AN ASIAN JOURNAL   11 ( 6 )   936 - 942   2016.3

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    DOI: 10.1002/asia.201600105

  • Control of Conformation and Chirality of Nonplanar pi-Conjugated Diporphyrins Using Substituents and Axial Ligands Reviewed

    Satoru Ito, Satoru Hiroto, Naoki Ousaka, Eiji Yashima, Hiroshi Shinokubo

    CHEMISTRY-AN ASIAN JOURNAL   11 ( 6 )   936 - 942   2016.3

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/asia.201600105

  • Remote Control of the Planar Chirality in Peptide-Bound Metallomacrocycles and Dynamic-to-Static Planar Chirality Control Triggered by Solvent-Induced 3(10)-to-alpha-Helix Transitions Reviewed

    Fumihiko Mamiya, Naoki Ousaka, Eiji Yashima

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   54 ( 48 )   14442 - 14446   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201507918

  • Remote Control of the Planar Chirality in Peptide-Bound Metallomacrocycles and Dynamic-to-Static Planar Chirality Control Triggered by Solvent-Induced 3(10)-to-alpha-Helix Transitions Reviewed

    Fumihiko Mamiya, Naoki Ousaka, Eiji Yashima

    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION   54 ( 48 )   14442 - 14446   2015.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/anie.201507918

  • Chirality- and sequence-selective successive self-sorting via specific homo- and complementary-duplex formations Reviewed

    Wataru Makiguchi, Junki Tanabe, Hidekazu Yamada, Hiroki Iida, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    NATURE COMMUNICATIONS   6   2015.6

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/ncomms8236

  • Chirality- and sequence-selective successive self-sorting via specific homo- and complementary-duplex formations Reviewed

    Wataru Makiguchi, Junki Tanabe, Hidekazu Yamada, Hiroki Iida, Daisuke Taura, Naoki Ousaka, Eiji Yashima

    NATURE COMMUNICATIONS   6   2015.6

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    DOI: 10.1038/ncomms8236

  • Remarkable Enhancement of Stability and Helix-sense Excess of Oligo(phenylene ethynylene) Foldamers Assisted by Linking with Achiral (Metallo)salen Tethers and Their Application to Asymmetric Catalysis Reviewed

    Naoki Ousaka, Tomoko Yamaguchi, Eiji Yashima

    CHEMISTRY LETTERS   43 ( 4 )   512 - 514   2014.4

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    DOI: 10.1246/cl.131168

  • Remarkable Enhancement of Stability and Helix-sense Excess of Oligo(phenylene ethynylene) Foldamers Assisted by Linking with Achiral (Metallo)salen Tethers and Their Application to Asymmetric Catalysis Reviewed

    Naoki Ousaka, Tomoko Yamaguchi, Eiji Yashima

    CHEMISTRY LETTERS   43 ( 4 )   512 - 514   2014.4

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    DOI: 10.1246/cl.131168

  • High-Fidelity Stereochemical Memory in a (Fe4L4)-L-II Tetrahedral Capsule Reviewed

    Ana M. Castilla, Naoki Ousaka, Rana A. Bilbeisi, Elisa Valeri, Tanya K. Ronson, Jonathan R. Nitschke

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   135 ( 47 )   17999 - 18006   2013.11

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    DOI: 10.1021/ja410117q

  • High-Fidelity Stereochemical Memory in a (Fe4L4)-L-II Tetrahedral Capsule Reviewed

    Ana M. Castilla, Naoki Ousaka, Rana A. Bilbeisi, Elisa Valeri, Tanya K. Ronson, Jonathan R. Nitschke

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   135 ( 47 )   17999 - 18006   2013.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja410117q

  • Anion-Driven Reversible Switching of Metal-Centered Stereoisomers in Metallopeptides Reviewed

    Naoki Ousaka, Yuki Takeyama, Eiji Yashima

    CHEMISTRY-A EUROPEAN JOURNAL   19 ( 15 )   4680 - 4685   2013.4

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    DOI: 10.1002/chem.201300361

  • Anion-Driven Reversible Switching of Metal-Centered Stereoisomers in Metallopeptides Reviewed

    Naoki Ousaka, Yuki Takeyama, Eiji Yashima

    CHEMISTRY-A EUROPEAN JOURNAL   19 ( 15 )   4680 - 4685   2013.4

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    DOI: 10.1002/chem.201300361

  • Efficient Long-Range Stereochemical Communication and Cooperative Effects in Self-Assembled Fe4L6 Cages Reviewed

    Naoki Ousaka, Sergio Grunder, Ana M. Castilla, Adam C. Whalley, J. Fraser Stoddart, Jonathan R. Nitschke

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   134 ( 37 )   15528 - 15537   2012.9

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    DOI: 10.1021/ja306615d

  • Efficient Long-Range Stereochemical Communication and Cooperative Effects in Self-Assembled Fe4L6 Cages Reviewed

    Naoki Ousaka, Sergio Grunder, Ana M. Castilla, Adam C. Whalley, J. Fraser Stoddart, Jonathan R. Nitschke

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   134 ( 37 )   15528 - 15537   2012.9

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    DOI: 10.1021/ja306615d

  • Chiral information harvesting in dendritic metallopeptides

    Naoki Ousaka, Yuki Takeyama, Hiroki Iida, Eiji Yashima

    NATURE CHEMISTRY   3 ( 11 )   856 - 861   2011.11

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    DOI: 10.1038/NCHEM.1146

  • Chiral information harvesting in dendritic metallopeptides

    Naoki Ousaka, Yuki Takeyama, Hiroki Iida, Eiji Yashima

    NATURE CHEMISTRY   3 ( 11 )   856 - 861   2011.11

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    DOI: 10.1038/NCHEM.1146

  • Total Helical-Sense Bias of an Achiral Peptide Main Chain Induced by a Chiral Side-Chain Bridge Reviewed

    Naoki Ousaka, Tomohiro Sato, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   131 ( 11 )   3820 - +   2009.3

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    DOI: 10.1021/ja8091714

  • Total Helical-Sense Bias of an Achiral Peptide Main Chain Induced by a Chiral Side-Chain Bridge Reviewed

    Naoki Ousaka, Tomohiro Sato, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   131 ( 11 )   3820 - +   2009.3

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    DOI: 10.1021/ja8091714

  • Transfer of Noncovalent Chiral Information along an Optically Inactive Helical Peptide Chain: Allosteric Control of Asymmetry of the C-Terminal Site by External Molecule that Binds to the N-Terminal Site Reviewed

    Naoki Ousaka, Yoshihito Inai

    JOURNAL OF ORGANIC CHEMISTRY   74 ( 4 )   1429 - 1439   2009.2

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    DOI: 10.1021/jo801686m

  • Transfer of Noncovalent Chiral Information along an Optically Inactive Helical Peptide Chain: Allosteric Control of Asymmetry of the C-Terminal Site by External Molecule that Binds to the N-Terminal Site Reviewed

    Naoki Ousaka, Yoshihito Inai

    JOURNAL OF ORGANIC CHEMISTRY   74 ( 4 )   1429 - 1439   2009.2

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    DOI: 10.1021/jo801686m

  • Chain-terminus triggered chiral memory in an optically inactive 3(10)-helical peptide Reviewed

    Naoki Ousaka, Yoshihito Inai, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 37 )   12266 - +   2008.9

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    DOI: 10.1021/ja805647k

  • Chain-terminus triggered chiral memory in an optically inactive 3(10)-helical peptide Reviewed

    Naoki Ousaka, Yoshihito Inai, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 37 )   12266 - +   2008.9

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    DOI: 10.1021/ja805647k

  • Intramolecular crosslinking of an optically inactive 3(10)-helical peptide: Stabilization of structure and helix sense Reviewed

    Naoki Ousaka, Tomohiro Sato, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 2 )   463 - +   2008.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/ja077857h

  • Intramolecular crosslinking of an optically inactive 3(10)-helical peptide: Stabilization of structure and helix sense Reviewed

    Naoki Ousaka, Tomohiro Sato, Reiko Kuroda

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   130 ( 2 )   463 - +   2008.1

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    DOI: 10.1021/ja077857h

  • Induction of a heterochiral helix through the covalent chiral domino effect originating in the "Schellman motif" Reviewed

    Naoki Ousaka, Yoshihito Inai

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   128 ( 46 )   14736 - 14737   2006.11

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    DOI: 10.1021/ja063873n

  • Induction of a heterochiral helix through the covalent chiral domino effect originating in the "Schellman motif" Reviewed

    Naoki Ousaka, Yoshihito Inai

    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY   128 ( 46 )   14736 - 14737   2006.11

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    DOI: 10.1021/ja063873n

  • Chiral interaction in peptide molecules: Effects of chiral peptide species on helix-sense induction in an N-terminal-free achiral peptide Reviewed

    Yoshihito Inai, Naoki Ousaka, Yasuhiro Ookouchi

    BIOPOLYMERS   82 ( 5 )   471 - 481   2006.8

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    DOI: 10.1002/bip.20491

  • Chiral interaction in peptide molecules: Effects of chiral peptide species on helix-sense induction in an N-terminal-free achiral peptide Reviewed

    Yoshihito Inai, Naoki Ousaka, Yasuhiro Ookouchi

    BIOPOLYMERS   82 ( 5 )   471 - 481   2006.8

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    DOI: 10.1002/bip.20491

  • Mechanism for the Noncovalent Chiral Domino Effect:  New Paradigm for the Chiral Role of the N-Terminal Segment in a 310-Helix Reviewed

    125 ( 27 )   8151 - 8162   2003.6

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    DOI: 10.1021/ja035040s

  • Mechanism for the Noncovalent Chiral Domino Effect:  New Paradigm for the Chiral Role of the N-Terminal Segment in a 310-Helix Reviewed

    125 ( 27 )   8151 - 8162   2003.6

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    DOI: 10.1021/ja035040s

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Presentations

  • ジスルフィドステープルの酸化還元を駆動力としたα-ヘリカルペプチドの可逆的な静的/動的らせん変換

    逢坂 直樹, Mark J MacLachlan, 秋根 茂久

    日本化学会第104春季年会  2024.3 

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    Event date: 2024.3

    Language:Japanese  

    Country:Other  

  • ジスルフィドステープルの酸化還元を駆動力としたα-ヘリカルペプチドの可逆的な静的/動的らせん変換

    逢坂 直樹, Mark J MacLachlan, 秋根 茂久

    日本化学会第104春季年会  2024.3 

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    Event date: 2024.3

    Language:Japanese  

    Country:Other  

  • ステープル化による動的および静的なα-ヘリカルペプチドの設計と合成

    逢坂直樹, Mark J. MacLachla, 秋根茂久

    第33回基礎有機化学討論会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Country:Other  

  • ステープル化による動的および静的なα-ヘリカルペプチドの設計と合成

    逢坂直樹, Mark J. MacLachla, 秋根茂久

    第33回基礎有機化学討論会  2023.9 

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    Event date: 2023.9

    Language:Japanese  

    Country:Other  

  • ステープル化したα-ヘリカルペプチドの合成と動的性質

    逢坂 直樹, Mark J. MacLachlan, 秋根 茂久

    日本化学会第103春季年会  2023.3 

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    Country:Other  

  • 分子内架橋法を用いた動的および静的なα-ヘリカルペプチドの設計と合成

    逢坂 直樹, Mark J. MacLachlan, 秋根茂久

    第72回高分子討論会  2023.9 

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    Country:Other  

  • ステープル化したα-ヘリカルペプチドの合成と動的性質

    逢坂 直樹, Mark J. MacLachlan, 秋根 茂久

    日本化学会第103春季年会  2023.3 

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    Language:Japanese  

    Country:Other  

  • 分子内架橋法を用いた動的および静的なα-ヘリカルペプチドの設計と合成

    逢坂 直樹, Mark J. MacLachlan, 秋根茂久

    第72回高分子討論会  2023.9 

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    Country:Other  

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MISC

  • Inside Cover: Control of Conformation and Chirality of Nonplanar π‐Conjugated Diporphyrins Using Substituents and Axial Ligands (Chem. Asian J. 6/2016)

    Chemistry – An Asian Journal   2016.3

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    Language:Others  

    DOI: 10.1002/asia.201600225

  • Inside Cover: Control of Conformation and Chirality of Nonplanar π‐Conjugated Diporphyrins Using Substituents and Axial Ligands (Chem. Asian J. 6/2016)

    Chemistry – An Asian Journal   2016.3

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    Language:Others  

    DOI: 10.1002/asia.201600225

  • 人工らせん高分子の設計と機能発現 : 最近の進歩

    逢坂 直樹, 八島 栄次

    高分子   2013.9

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  • 人工らせん高分子の設計と機能発現 : 最近の進歩

    逢坂 直樹, 八島 栄次

    高分子   2013.9

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Professional Memberships

  • 日本化学会

  • 高分子学会

  • 日本化学会

  • 高分子学会

Research Projects

  • キラル情報の長距離伝播と増幅能を有する超分子らせんペプチドの創製と応用

    Grant number:22K05220  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • キラル情報の長距離伝播と増幅能を有する超分子らせんペプチドの創製と応用

    Grant number:22K05220  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 記憶力を有するラセン高分子の創成と究極機能の開拓

    Grant number:18H05209  2018 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 記憶力を有するラセン高分子の創成と究極機能の開拓

    Grant number:18H05209  2018 - 2022

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ラセン空孔をキラル包接場に利用した超分子ラセン複合体の創成と応用

    Grant number:18H03916  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ラセン空孔をキラル包接場に利用した超分子ラセン複合体の創成と応用

    Grant number:18H03916  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 不斉ナノ空間を有する超分子型不斉反応場の創製

    Grant number:18H04251  2018 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 不斉ナノ空間を有する超分子型不斉反応場の創製

    Grant number:18H04251  2018 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 協奏的な不斉情報伝達と階層的な不斉増幅を利用したキラル超分子の創製と応用

    Grant number:17K14470  2017 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 協奏的な不斉情報伝達と階層的な不斉増幅を利用したキラル超分子の創製と応用

    Grant number:17K14470  2017 - 2018

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 動的面不斉を有する超分子型不斉触媒の創製

    Grant number:16H01016  2016 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 動的面不斉を有する超分子型不斉触媒の創製

    Grant number:16H01016  2016 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 階層的なキラル情報伝達システムの創製と応用

    Grant number:26810047  2014 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 階層的なキラル情報伝達システムの創製と応用

    Grant number:26810047  2014 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ラセン構造からなるナノ空間の精密制御を基盤とする革新的キラル材料の創製

    Grant number:25220804  2013 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ラセン構造からなるナノ空間の精密制御を基盤とする革新的キラル材料の創製

    Grant number:25220804  2013 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 人工らせんペプチドを用いた二重らせん構造の構築と不斉触媒への応用

    Grant number:10J02692  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 人工らせんペプチドを用いた二重らせん構造の構築と不斉触媒への応用

    Grant number:10J02692  2010 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

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