Updated on 2026/06/04

Information

 

写真a

 
NODA TAKAHIRO
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
Homepage
External link

Research Areas

  • Life Science / Neuroscience-general

Degree

  • Information Science and Technology （ 2012.9 The University of Tokyo ）

Research History

  • Kyushu University  Assistant Professor 

    2024.7 - 2025.6

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    Country：Japan

  • Johannes Gutenberg University Mainz, University Medical Center Institute of Physiology Academic Researcher 

    2018.5 - 2024.6

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    Country：Germany

  • Technical University Munich Institute of Neuroscience Academic Researcher 

    2014.4 - 2018.4

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    Country：Germany

  • The University of Tokyo  Academic Researcher 

    2012.10 - 2014.3

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    Country：Japan

  • The University of Tokyo 先端科学技術研究センター Academic Researcher 

    2009.4 - 2012.3

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    Country：Japan

  • Kyushu University Faculty of Medical Sciences Assistant Professor 

    2024.7 - Present

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    Country：Japan

  • Johannes Gutenberg University of Mainz Institute of Physiology, Univercity Medical Center ポスドク研究員 

    2018.5 - Present

  • University of Maryland Neural Systems Laboratory Academic Researcher 

    2012.10 - 2012.12

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    Country：United States

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Education

  • The University of Tokyo     情報理工学系研究科

    2009.4 - 2012.9

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    Country：Japan

  • The University of Tokyo     情報理工学系研究科

    2007.4 - 2009.3

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    Country：Japan

  • The University of Tokyo   工学部  

    2003.4 - 2007.3

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    Country：Japan

Research Interests・Research Keywords

  • Research theme： Homeostasis of representational map in the neocortex

    Keyword： auditory cortex, sound representation, two-photon imaging, representational drift

    Research period： 2018.5 - 2024.12

Awards

  • 論文奨励賞

    2013.9   電気学会　電子・情報・システム部門大会  

Papers

  • Homeostasis of a representational map in the neocortex

    [Takahiro Noda,Eike Kienle,Jens-Bastian Eppler,Dominik F. Aschauer,Matthias Kaschube,Yonatan Loewenstein,Simon Rumpel]

    Nature Neuroscience   2025.6

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    Authorship：Lead author  

    加齢や神経変性による神経細胞の喪失にもかかわらず、大脳皮質の感覚処理は驚くほど安定している。本研究ではマウス聴覚野を対象に、神経細胞除去後も表現地図が回復する仕組みを示し、抑制性ニューロンの喪失が回復を妨げることを明らかにした。

  • Homeostasis of a representational map in the neocortex Reviewed

    Takahiro Noda, Eike Kienle, Jens-Bastian Eppler, Dominik F. Aschauer, Matthias Kaschube, Yonatan Loewenstein, Simon Rumpel

    Nature Neuroscience   2025.6   （ ISSN:1097-6256 eISSN:1546-1726 ）

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Cortical function, including sensory processing, is surprisingly resilient to neuron loss during aging and neurodegeneration. In this Article, we used the mouse auditory cortex to investigate how homeostatic mechanisms protect the representational map of sounds after neuron loss. We combined two-photon calcium imaging with targeted microablation of 30–40 sound-responsive neurons in layer 2/3. Microablation led to a temporary disturbance of the representational map, but it recovered in the following days. Recovery was primarily driven by neurons that were initially unresponsive to sounds but gained responsiveness and strengthened the network’s correlation structure. By contrast, selective microablation of inhibitory neurons caused prolonged disturbance, characterized by destabilized sound responses. Our results link individual neuron tuning and plasticity to the stability of the population-level representational map, highlighting homeostatic mechanisms that safeguard sensory processing in the neocortex.

    DOI： 10.1038/s41593-025-01982-7

    Other Link： https://www.nature.com/articles/s41593-025-01982-7

  • Representational maps in the brain: concepts, approaches, and applications.

    [Takahiro Noda,Dominik F Aschauer,Anna R Chambers,Johannes P-H Seiler,Simon Rumpel]

    Frontiers in cellular neuroscience   2024

  • Representational maps in the brain: concepts, approaches, and applications. Reviewed International journal

    Takahiro Noda, Dominik F Aschauer, Anna R Chambers, Johannes P-H Seiler, Simon Rumpel

    Frontiers in cellular neuroscience   18   1366200 - 1366200   2024

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Neural systems have evolved to process sensory stimuli in a way that allows for efficient and adaptive behavior in a complex environment. Recent technological advances enable us to investigate sensory processing in animal models by simultaneously recording the activity of large populations of neurons with single-cell resolution, yielding high-dimensional datasets. In this review, we discuss concepts and approaches for assessing the population-level representation of sensory stimuli in the form of a representational map. In such a map, not only are the identities of stimuli distinctly represented, but their relational similarity is also mapped onto the space of neuronal activity. We highlight example studies in which the structure of representational maps in the brain are estimated from recordings in humans as well as animals and compare their methodological approaches. Finally, we integrate these aspects and provide an outlook for how the concept of representational maps could be applied to various fields in basic and clinical neuroscience.

    DOI： 10.3389/fncel.2024.1366200

    PubMed

  • Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.

    [Takahiro Noda,Hirokazu Takahashi]

    Cerebral cortex   2023.11

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    Authorship：Lead author  

  • Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat. Reviewed International journal

    Takahiro Noda, Hirokazu Takahashi

    Cerebral cortex (New York, N.Y. : 1991)   2023.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    The awake cortex is characterized by a higher level of ongoing spontaneous activity, but it has a better detectability of weak sensory inputs than the anesthetized cortex. However, the computational mechanism underlying this paradoxical nature of awake neuronal activity remains to be elucidated. Here, we propose a hypothetical stochastic resonance, which improves the signal-to-noise ratio (SNR) of weak sensory inputs through nonlinear relations between ongoing spontaneous activities and sensory-evoked activities. Prestimulus and tone-evoked activities were investigated via in vivo extracellular recording with a dense microelectrode array covering the entire auditory cortex in rats in both awake and anesthetized states. We found that tone-evoked activities increased supralinearly with the prestimulus activity level in the awake state and that the SNR of weak stimulus representation was optimized at an intermediate level of prestimulus ongoing activity. Furthermore, the temporally intermittent firing pattern, but not the trial-by-trial reliability or the fluctuation of local field potential, was identified as a relevant factor for SNR improvement. Since ongoing activity differs among neurons, hypothetical stochastic resonance or "sparse network stochastic resonance" might offer beneficial SNR improvement at the single-neuron level, which is compatible with the sparse representation in the sensory cortex.

    DOI： 10.1093/cercor/bhad428

    PubMed

  • In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution.

    [Carsten H Tischbirek,Takahiro Noda,Manabu Tohmi,Antje Birkner,Israel Nelken,Arthur Konnerth]

    Cell reports   2019.4

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    Authorship：Lead author  

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Presentations

Professional Memberships

  • 日本神経科学学会

    2012.4 - Present

Committee Memberships

  • Frontiers in Cognition   Review Editor   Foreign country

    2023.4 - Present   

  • Frontiers in Cognition   Review Editor  

    2023.4 - Present   

Research Projects

Class subject

Media Coverage

  • Brain Adapts to Neuron Loss Through Rapid Rewiring Internet

    neurosciencenews.com  2025.6

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    Author：Other 

  • Resilient cortical maps Newspaper, magazine

    Nature Neuroscience  2025.6

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    Author：Other 

  • Brain Adapts to Neuron Loss Through Rapid Rewiring Internet

    neurosciencenews.com  2025.6

  • Resilient cortical maps Newspaper, magazine

    Nature Neuroscience  News & Views  2025.6

  • Cerebral cortex networks rapidly reorganize to compensate for lost neurons Internet

    Raw News  2025.6

Travel Abroad

  • 2023.3

    Staying countory name 1：Canada   Staying institution name 1：COSYNE2023 committee in Montreal