Updated on 2025/01/27

Information

 

写真a

 
WONG WILLY
 
Organization
Faculty of Information Science and Electrical Engineering Department of Informatics Professor
Title
Professor
Contact information
メールアドレス
Tel
0928023805‬

Research Areas

  • Informatics / Perceptual information processing

  • Life Science / Neuroscience-general

  • Informatics / Life, health and medical informatics

Research History

  • Professor, Faculty of Information Science and Electrical Engineering Department of Informatics, Kyushu University

    2024.9 - Present

  • Professor, Dept. of Electrical and Computer Engineering, University of Toronto, Canada

    2020.7 - 2024.8

  • Associate Professor, Dept. of Electrical and Computer Engineering, University of Toronto, Canada

    2006.7 - 2020.7

  • Assistant Professor, Dept. of Electrical and Computer Engineering, University of Toronto, Canada

    2000.10 - 2006.7

  • Postdoctoral Fellow, Technical University of Eindhoven, The Netherlands

    1999.4 - 2000.9

  • NSERC Postdoctoral Fellow, University of Cambridge, U.K.

    1998.4 - 1999.3

  • JSPS Postdoctoral Fellow, Toyama Prefectural University, Japan

    1997.4 - 1998.3

▼display all

Education

  • Doctor's Course, Dept. of Physics, University of Toronto, Canada

    1993.9 - 1996.12

  • Master's Course, Dept. of Physics, University of Toronto, Canada

    1992.9 - 1993.9

  • Dept. of Physics, University of Toronto, Canada

    1988.9 - 1992.5

Research Interests・Research Keywords

  • Research theme:Vision

    Keyword:Vision

    Research period: 2024

  • Research theme:Theoretical neuroscience

    Keyword:Theoretical neuroscience

    Research period: 2024

  • Research theme:Neuroengineering

    Keyword:Neuroengineering

    Research period: 2024

  • Research theme:Machine learning

    Keyword:Machine learning

    Research period: 2024

  • Research theme:Audition

    Keyword:Audition

    Research period: 2024

Papers

  • Virtual Reality Portable Perimetry and Home Monitoring of Glaucoma: Retention and Compliance Over a 2-year Period

    Runjie B. Shi, Leo Y. Li-Han, Irfan Kherani, Graham E. Trope, Yvonne M. Buys, Willy Wong, Moshe Eizenman

    Ophthalmology Science   100639 - 100639   2024.10   ISSN:2666-9145

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Elsevier BV  

    DOI: 10.1016/j.xops.2024.100639

  • TORONTO: A Trial-Oriented Multi-Dimensional Psychometric Testing Algorithm

    R. Shi, M. Eizenman, Y. Li, W. Wong

    Journal of Vision   2024.7

  • Auditory temporal discrimination from the perspective of gap

    S. Mori, H. Cho, W. Wong

    Timing and Time Perception   2024.4

  • Improving the robustness of the Sequentially Optimized Reconstruction Strategy (SORS) for visual field testing

    Runjie Bill Shi, Moshe Eizenman, Yan Li, Willy Wong

    PLOS ONE   2024.4

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0301419

  • Using Fused Data from Perimetry and Optical Coherence Tomography to Improve the Detection of Visual Field Progression in Glaucoma

    Leo Yan Li-Han, Moshe Eizenman, Runjie Bill Shi, Yvonne M. Buys, Graham E. Trope, Willy Wong

    Bioengineering   2024.3

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/bioengineering11030250

  • A Fundamental Inequality Governing the Rate Coding Response of Sensory Neurons

    Wong, W.

    Biological Cybernetics   117 ( 4-5 )   2023.8   ISSN:1432-0770

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00422-023-00971-y

    Scopus

  • A Data-Driven Model for Simulating Longitudinal Visual Field Tests in Glaucoma

    Li, Y., Eizenman, M., Shi, R.B., Buys, Y.M., Trope, G.E., Wong, W.

    Translational Vision Science and Technology   12 ( 6 )   2023.6   ISSN:2164-2591

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1167/tvst.12.6.27

    Scopus

  • Modelling the visual response to an OUReP retinal prosthesis with photoelectric dye coupled to polyethylene film

    Yamashita, K., Sundaram, P., Uchida, T., Matsuo, T., Wong, W.

    Journal of Neural Engineering   18 ( 4 )   045006 - 045006   2021.8   ISSN:1741-2552

     More details

    Publishing type:Research paper (scientific journal)   Publisher:{IOP} Publishing  

    DOI: 10.1088/1741-2552/abf892

    Scopus

  • On the rate coding response of peripheral sensory neurons

    Wong, W.

    Biological Cybernetics   114 ( 6 )   2020.12   ISSN:1432-0770

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s00422-020-00848-4

    Scopus

  • Consilience in the Peripheral Sensory Adaptation Response

    Willy Wong

    Frontiers in Human Neuroscience   15   2020.2   ISSN:1662-5161

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1101/2020.02.17.953448

    Scopus

    PubMed

  • Use of Machine Learning for Predicting Escitalopram Treatment Outcome From Electroencephalography Recordings in Adult Patients With Depression

    Zhdanov, A., Atluri, S., Wong, W., Vaghei, Y., Daskalakis, Z.J., Blumberger, D.M., Frey, B.N., Giacobbe, P., Lam, R.W., Milev, R., Mueller, D.J., Turecki, G., Parikh, S.V., Rotzinger, S., Soares, C.N., Brenner, C.A., Vila-Rodriguez, F., McAndrews, M.P., Kleffner, K., Alonso-Prieto, E., Arnott, S.R., Foster, J.A., Strother, S.C., Uher, R., Kennedy, S.H., Farzan, F.

    JAMA Network Open   3 ( 1 )   2020.1   ISSN:2574-3805

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamanetworkopen.2019.18377

    Scopus

  • Auditory gap detection: psychometric functions and insights into the underlying neural activity

    Mori, S., Kikuchi, Y., Hirose, N., Lepage, H., Wong, W.

    Biological Cybernetics   112 ( 6 )   575 - 584   2018.12   ISSN:1432-0770

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1007/s00422-018-0786-6

    Scopus

  • Magnetic seizure therapy reduces suicidal ideation and produces neuroplasticity in treatment-resistant depression

    Sun, Y., Blumberger, D.M., Mulsant, B.H., Rajji, T.K., Fitzgerald, P.B., Barr, M.S., Downar, J., Wong, W., Farzan, F., Daskalakis, Z.J.

    Translational Psychiatry   8 ( 1 )   2018.11   ISSN:2158-3188

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:title>Abstract</jats:title><jats:p>Therapeutic seizures may work for treatment-resistant depression (TRD) by producing neuroplasticity. We evaluated whether magnetic seizure therapy (MST) produces changes in suicidal ideation and neuroplasticity as indexed through transcranial magnetic stimulation and electroencephalography (TMS-EEG) of the dorsolateral prefrontal cortex (DLPFC). Twenty-three patients with TRD were treated with MST. Changes in suicidal ideation was assessed through the Scale for Suicidal Ideation (SSI). Before and after the treatment course, neuroplasticity in excitatory and inhibitory circuits was assessed with TMS-EEG measures of cortical-evoked activity (CEA) and long-interval cortical inhibition (LICI) from the left DLPFC, and the left motor cortex as a control condition. As in our previous report, the relationship between TMS-EEG measures and suicidal ideation was examined with the SSI. Results show that 44.4% of patients experienced resolution of suicidal ideation. Based on DLPFC assessment, MST produced significant CEA increase over the frontal central electrodes (cluster <jats:italic>p</jats:italic> &lt; 0.05), but did not change LICI on a group level. MST also reduced the SSI scores (<jats:italic>p</jats:italic> &lt; 0.005) and the amount of reduction correlated with the decrease in LICI over the right frontal central electrodes (cluster <jats:italic>p</jats:italic> &lt; 0.05; rho = 0.73 for Cz). LICI change identified patients who were resolved of suicidal ideation with 90% sensitivity and 88% specificity (AUC = 0.9, <jats:italic>p</jats:italic> = 0.004). There was no significant finding with motor cortex assessment. Overall, MST produced significant rates of resolution of suicidal ideation. MST also produced neuroplasticity in the frontal cortex, likely through long-term potentiation (LTP)-like mechanisms. The largest reduction in suicidal ideation was demonstrated in patients showing concomitant decreases in cortical inhibition—a mechanism linked to enhanced LTP-like plasticity. These findings provide insights into the mechanisms through which patients experience resolution of suicidal ideation following seizure treatments in depression.</jats:p>

    DOI: 10.1038/s41398-018-0302-8

    Scopus

  • Real time hearing enhancement in crowded social environments with noise gating

    Wang, B., Wong, W.

    Speech Communication   99   2018.5   ISSN:0167-6393

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.specom.2018.03.010

    Scopus

  • Selective modulation of brain network dynamics by seizure therapy in treatment-resistant depression

    Atluri, S., Wong, W., Moreno, S., Blumberger, D.M., Daskalakis, Z.J., Farzan, F.

    NeuroImage: Clinical   20   2018   ISSN:2213-1582

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.nicl.2018.10.015

    Scopus

  • Reconstruction of reaching movement trajectories using electrocorticographic signals in humans

    Talakoub, O., Marquez-Chin, C., Popovic, M.R., Navarro, J., Fonoff, E.T., Hamani, C., Wong, W.

    PLoS ONE   12 ( 9 )   2017.9   ISSN:1932-6203

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Public Library of Science ({PLoS})  

    DOI: 10.1371/journal.pone.0182542

    Scopus

  • Standardization of electroencephalography for multi-site, multi-platform and multi-investigator studies: Insights from the canadian biomarker integration network in depression

    Farzan, F., Atluri, S., Frehlich, M., Dhami, P., Kleffner, K., Price, R., Lam, R.W., Frey, B.N., Milev, R., Ravindran, A., McAndrews, M.P., Wong, W., Blumberger, D., Daskalakis, Z.J., Vila-Rodriguez, F., Alonso, E., Brenner, C.A., Liotti, M., Dharsee, M., Arnott, S.R., Evans, K.R., Rotzinger, S., Kennedy, S.H.

    Scientific Reports   7 ( 1 )   2017.8   ISSN:2045-2322

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:title>Abstract</jats:title><jats:p>Subsequent to global initiatives in mapping the human brain and investigations of neurobiological markers for brain disorders, the number of multi-site studies involving the collection and sharing of large volumes of brain data, including electroencephalography (EEG), has been increasing. Among the complexities of conducting multi-site studies and increasing the shelf life of biological data beyond the original study are <jats:italic>timely</jats:italic> standardization and documentation of relevant study parameters. We present the insights gained and guidelines established within the EEG working group of the Canadian Biomarker Integration Network in Depression (CAN-BIND). CAN-BIND is a multi-site, multi-investigator, and multi-project network supported by the Ontario Brain Institute with access to Brain-CODE, an informatics platform that hosts a multitude of biological data across a growing list of brain pathologies. We describe our approaches and insights on documenting and standardizing parameters across the study design, data collection, monitoring, analysis, integration, knowledge-translation, and data archiving phases of CAN-BIND projects. We introduce a custom-built EEG toolbox to track data preprocessing with open-access for the scientific community. We also evaluate the impact of variation in equipment setup on the accuracy of acquired data. Collectively, this work is intended to inspire establishing comprehensive and standardized guidelines for multi-site studies.</jats:p>

    DOI: 10.1038/s41598-017-07613-x

    Scopus

  • Time-course of coherence in the human basal ganglia during voluntary movements

    Talakoub, O., Neagu, B., Udupa, K., Tsang, E., Chen, R., Popovic, M.R., Wong, W.

    Scientific Reports   6 ( 1 )   2016.12   ISSN:2045-2322

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    <jats:title>Abstract</jats:title><jats:p>We are interested in characterizing how brain networks interact and communicate with each other during voluntary movements. We recorded electrical activities from the globus pallidus pars interna (GPi), subthalamic nucleus (STN) and the motor cortex during voluntary wrist movements. Seven patients with dystonia and six patients with Parkinson’s disease underwent bilateral deep brain stimulation (DBS) electrode placement. Local field potentials from the DBS electrodes and scalp EEG from the electrodes placed over the motor cortices were recorded while the patients performed externally triggered and self-initiated movements. The coherence calculated between the motor cortex and STN or GPi was found to be coupled to its power in both the beta and the gamma bands. The association of coherence with power suggests that a coupling in neural activity between the basal ganglia and the motor cortex is required for the execution of voluntary movements. Finally, we propose a mathematical model involving coupled neural oscillators which provides a possible explanation for how inter-regional coupling takes place.</jats:p>

    DOI: 10.1038/srep34930

    Scopus

  • TMSEEG: A MATLAB-based graphical user interface for processing electrophysiological signals during transcranial magnetic stimulation

    Atluri, S., Frehlich, M., Mei, Y., Dominguez, L.G., Rogasch, N.C., Wong, W., Daskalakis, Z.J., Farzan, F.

    Frontiers in Neural Circuits   10 ( OCT )   2016.10   ISSN:1662-5110

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.3389/fncir.2016.00078

    Scopus

  • Indicators for remission of suicidal ideation followingmagnetic seizure therapy in patients with treatment-resistant depression

    Sun, Y., Farzan, F., Mulsant, B.H., Rajji, T.K., Fitzgerald, P.B., Barr, M.S., Downar, J., Wong, W., Blumberger, D.M., Daskalakis, Z.J.

    JAMA Psychiatry   73 ( 4 )   2016.4   ISSN:2168-622X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1001/jamapsychiatry.2015.3097

    Scopus

  • Deep brain stimulation modulates gamma oscillations and theta-gamma coupling in treatment resistant depression

    Sun, Y., Giacobbe, P., Tang, C.W., Barr, M.S., Rajji, T., Kennedy, S.H., Fitzgerald, P.B., Lozano, A.M., Wong, W., Daskalakis, Z.J.

    Brain Stimulation   8 ( 6 )   2015.11   ISSN:1876-4754

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.brs.2015.06.010

    Scopus

  • Advances in modern mental chronometry

    Medina, J.M., Wong, W., D{\'i}az, J.A., Colonius, H.

    Frontiers in Human Neuroscience   9 ( MAY )   2015.5   ISSN:1662-5161

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Frontiers in Human Neuroscience  

    DOI: 10.3389/fnhum.2015.00256

    Scopus

  • Temporal alignment of electrocorticographic recordings for upper limb movement

    Talakoub, O., Popovic, M.R., Navaro, J., Hamani, C., Fonoff, E.T., Wong, W.

    Frontiers in Neuroscience   9 ( JAN )   2015.1   ISSN:1662-453X

     More details

    Publishing type:Research paper (scientific journal)   Publisher:Frontiers Media {SA}  

    DOI: 10.3389/fnins.2014.00431

    Scopus

  • A novel method for removal of deep brain stimulation artifact from electroencephalography

    Sun, Y., Farzan, F., Dominguez, L.G., Barr, M.S., Giacobbe, P., Lozano, A.M., Wong, W., Daskalakis, Z.J.

    Journal of Neuroscience Methods   237   33 - 40   2014.11   ISSN:1872-678X

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/j.jneumeth.2014.09.002

    Scopus

  • BayMiR: Inferring evidence for endogenous miRNA-induced gene repression from mRNA expression profiles

    Radfar, H., Wong, W., Morris, Q.

    BMC Genomics   14 ( 1 )   2013.12   ISSN:1471-2164

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:title>Abstract</jats:title>
    <jats:sec>
    <jats:title>Background</jats:title>
    <jats:p>Popular miRNA target prediction techniques use sequence features to determine the functional miRNA target sites. These techniques commonly ignore the cellular conditions in which miRNAs interact with their targets in vivo. Gene expression data are rich resources that can complement sequence features to take into account the context dependency of miRNAs.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>We introduce BayMiR, a new computational method, that predicts the functionality of potential miRNA target sites using the activity level of the miRNAs inferred from genome-wide mRNA expression profiles. We also found that mRNA expression variation can be used as another predictor of functional miRNA targets. We benchmarked BayMiR, the expression variation, Cometa, and the TargetScan “context scores” on two tasks: predicting independently validated miRNA targets and predicting the decrease in mRNA abundance in miRNA overexpression assays. BayMiR performed better than all other methods in both benchmarks and, surprisingly, the variation index performed better than Cometa and some individual determinants of the TargetScan context scores. Furthermore, BayMiR predicted miRNA target sets are more consistently annotated with GO and KEGG terms than similar sized random subsets of genes with conserved miRNA seed regions. BayMiR gives higher scores to target sites residing near the poly(A) tail which strongly favors mRNA degradation using poly(A) shortening. Our work also suggests that modeling multiplicative interactions among miRNAs is important to predict endogenous mRNA targets.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>We develop a new computational method for predicting the target mRNAs of miRNAs. BayMiR applies a large number of mRNA expression profiles and successfully identifies the mRNA targets and miRNA activities without using miRNA expression data. The BayMiR package is publicly available and can be readily applied to any mRNA expression data sets.</jats:p>
    </jats:sec>

    DOI: 10.1186/1471-2164-14-592

    Scopus

  • Gaze patterns and audiovisual speech enhancement

    Yi, A., Wong, W., Eizenman, M.

    Journal of Speech, Language, and Hearing Research   56 ( 2 )   471 - 480   2013.4   ISSN:1092-4388

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:American Speech Language Hearing Association  

    <jats:sec>
    <jats:title>Purpose</jats:title>
    <jats:p>In this study, the authors sought to quantify the relationships between speech intelligibility (perception) and gaze patterns under different auditory–visual conditions.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Method</jats:title>
    <jats:p>Eleven subjects listened to low-context sentences spoken by a single talker while viewing the face of one or more talkers on a computer display. Subjects either maintained their gaze at a specific distance (0°, 2.5°, 5°, 10°, and 15°) from the center of the talker's mouth (CTM) or moved their eyes freely on the computer display. Eye movements were monitored with an eye-tracking system, and speech intelligibility was evaluated by the mean percentage of correctly perceived words.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Results</jats:title>
    <jats:p>With a single talker and a fixed point of gaze, speech intelligibility was similar for all fixations within 10° of the CTM. With visual cues from two talker faces and a speech signal from one of the talkers, speech intelligibility was similar to that of a single talker for fixations within 2.5° of the CTM. With natural viewing of a single talker, gaze strategy changed with speech-signal-to-noise ratio (SNR). For low speech-SNR, a strategy that brought the point of gaze directly to within 2.5° of the CTM was used in approximately 80% of trials, whereas in high speech-SNR it was used in only approximately 50% of trials.</jats:p>
    </jats:sec>
    <jats:sec>
    <jats:title>Conclusions</jats:title>
    <jats:p>With natural viewing of a single talker and high speech-SNR, subjects can shift their gaze between points on the talker's face without compromising speech intelligibility. With low-speech SNR, subjects change their gaze patterns to fixate primarily on points that are in close proximity to the talker's mouth. The latter strategy is essential to optimize speech intelligibility in situations where there are simultaneous visual cues from multiple talkers (i.e., when some of the visual cues are distracters).</jats:p>
    </jats:sec>

    DOI: 10.1044/1092-4388(2012/10-0288)

    Scopus

  • Computational prediction of intronic microRNA targets using host gene expression reveals novel regulatory mechanisms

    Radfar, M.H., Wong, W., Morris, Q.

    PLoS ONE   6 ( 6 )   2011.6   ISSN:1932-6203

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0019312

    Scopus

  • Noise exposure of musicians of a ballet orchestra

    Qian, C.L., Behar, A., Wong, W.

    Noise and Health   13 ( 50 )   2011   ISSN:1463-1741

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.4103/1463-1741.74002

    Scopus

  • Approximating the time-frequency representation of biosignals with chirplets

    Wong, W., Talakoub, O., Cui, J.

    Eurasip Journal on Advances in Signal Processing   2010 ( 1 )   2010.12   ISSN:1687-6172

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Springer Science and Business Media {LLC}  

    DOI: 10.1155/2010/857685

    Scopus

  • Reliability of long-interval cortical inhibition in healthy human subjects: A TMS-EEG study

    Farzan, F., Barr, M.S., Levinson, A.J., Chen, R., Wong, W., Fitzgerald, P.B., Daskalakis, Z.J.

    Journal of Neurophysiology   104 ( 3 )   2010.9   ISSN:0022-3077

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p> Cortical inhibition (CI) is measured by transcranial magnetic stimulation (TMS) combined with electromyography (EMG) through long-interval CI (LICI) and cortical silent period (CSP) paradigms. Recently, we illustrated that LICI can be measured from the dorsolateral prefrontal cortex (DLPFC) through combined TMS with electroencephalography (EEG). We further demonstrated that LICI had different effects on cortical oscillations in the DLPFC compared with motor cortex. The purpose of this study was to establish the validity and reliability of TMS–EEG indices of CI and to replicate our previous findings in an extended sample. The validity of TMS–EEG was examined by evaluating its relationship to standard EMG measures of LICI and the CSP in the left motor cortex in 36 and 16 subjects, respectively. Test–retest reliability was examined in 14 subjects who returned for a repeat session within 7 days of the first session. LICI was applied to the left DLPFC in 30 subjects to compare LICI in the DLPFC with that in the motor cortex. In the motor cortex, EEG measures of LICI correlated with EMG measures of LICI and CSP. All indices of LICI showed high test–retest reliability in motor cortex and DLPFC. Gamma and beta oscillations were significantly inhibited in the DLPFC but not in the motor cortex, confirming previous findings in an extended sample. These findings demonstrate that indexing LICI through TMS combined with EEG is a valid and reliable method to evaluate inhibition from motor and prefrontal regions. </jats:p>

    DOI: 10.1152/jn.00279.2010

    Scopus

  • Coronal view ultrasound imaging of movement in different segments of the tongue during paced recital: Findings from four normal speakers and a speaker with partial glossectomy

    Bressmann, T., Flowers, H., Wong, W., Irish, J.C.

    Clinical Linguistics and Phonetics   24 ( 8 )   2010.8   ISSN:0269-9206

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3109/02699201003687309

    Scopus

  • Evidence for gamma inhibition deficits in the dorsolateral prefrontal cortex of patients with schizophrenia

    Farzan, F., Barr, M.S., Levinson, A.J., Chen, R., Wong, W., Fitzgerald, P.B., Daskalakis, Z.J.

    Brain   133 ( 5 )   2010.5   ISSN:1460-2156

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1093/brain/awq046

    Scopus

  • Suppression of γ-oscillations in the dorsolateral prefrontal cortex following long interval cortical inhibition: A TMS-EEG study

    Farzan, F., Barr, M.S., Wong, W., Chen, R., Fitzgerald, P.B., Daskalakis, Z.J.

    Neuropsychopharmacology   34 ( 6 )   2009.5   ISSN:0893-133X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/npp.2008.211

    Scopus

  • Visual evoked potential analysis using adaptive chirplet transform

    Cui, J., Wong, W.

    Advanced Biosignal Processing   2009   ISBN:9783540895053

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/978-3-540-89506-0_11

    Scopus

  • A linear model of acoustic-to-facial mapping: Model parameters, data set size, and generalization across speakers

    Craig, M.S., Van Lieshout, P., Wong, W.

    Journal of the Acoustical Society of America   124 ( 5 )   2008.11   ISSN:0001-4966

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>The relationship between acoustic and visual speech is important for understanding speech perception, but it also forms the basis behind a type of facial animator, which can predict facial motion during speech given an acoustic input. This relationship was examined by revisiting a linear transformation model of audio-visual speech production. A mathematical model is constructed whereby the visual aspect of speech is reproduced from the acoustic signal via a linear transformation. Unlike previous studies in this area, this paper will address specific aspects of the model as related to the effects of window size for acoustic framing and the critical size of the training set. On average, facial motion is predicted with a correlation of 0.70 to the recorded motion, when the model is trained and then tested on the same subject. This is comparable to previous studies using either similar or different model approaches. Using a model trained on other subjects and then applying it to a new subject resulted in a prediction correlation of 0.65. Furthermore, acoustic windows of 100ms and a data set of approximately 40 sentences are required for maximum predictability. The results are interpreted in terms of the underlying assumptions of the model.</jats:p>

    DOI: 10.1121/1.2982369

    Scopus

  • Low‐level audiovisual synchrony: Experiments and model

    SHEENA LUU, WILLY WONG, HAFIZ NOORDIN

    Japanese Psychological Research   2008.11   ISSN:0021-5368

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p><jats:bold>Abstract: </jats:bold> We have carried out experiments to explore the effect of prior knowledge and expectation on the detection of audiovisual synchrony. By expanding on earlier methodologies, we have shown that the perception of synchrony is not affected by prior knowledge of lag type (i.e., visual signal precedes audio signal or vice versa). This result suggests that higher‐level cognitive processes like expectation do not play a significant role in synchrony perception. We also introduce here a systems‐level model based on cross‐correlation that is compatible with both the observations of our experiments and with the observations of other studies.</jats:p>

    DOI: 10.1111/j.1468-5884.2008.00377.x

  • Investigation of short-term changes in visual evoked potentials with windowed adaptive chirplet transform

    Cui, J., Wong, W.

    IEEE Transactions on Biomedical Engineering   55 ( 4 )   2008.4   ISSN:0018-9294

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1109/TBME.2008.918439

    Scopus

  • Noise exposure of opera musicians

    MacDonald, E.N., Behar, A., Wong, W., Kunov, H.

    Canadian Acoustics - Acoustique Canadienne   36 ( 4 )   2008   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • The ANSI standard S12. 68-2007 method of estimating effective a-weighted sound pressure levels when hearing protectors are worn: A canadian perspective

    Voix, J., Behar, A., Wong, W.

    Canadian Acoustics - Acoustique Canadienne   36 ( 3 )   2008   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • Suitability of a UV-based video recording system for the analysis of small facial motions during speech

    Craig, M., van Lieshout, P., Wong, W.

    Speech Communication   49 ( 9 )   2007.9   ISSN:0167-6393

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.specom.2007.04.011

    Scopus

  • Recognition of temporal patterns: From engineering to psychology and back again

    Wong, W.

    Canadian Journal of Experimental Psychology   61 ( 2 )   2007.6   ISSN:1196-1961

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1037/cjep2007016

    Scopus

  • Risk of hearing loss in orchestra musicians: Review of the literature

    Behar, A., Wong, W., Kunov, H.

    Medical Problems of Performing Artists   21 ( 4 )   2006.12   ISSN:0885-1158

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>We reviewed 13 papers on noise exposure of orchestral musicians and found that the question of whether orchestra musicians are overexposed does not appear to have a clear answer. To find relevant papers, we researched three databases (Scholar, Scopos, and Medline), which yielded 6,
    9, and 17 papers, respectively (including duplicates). A number of papers in the reviewed literature lacked basic descriptions concerning such issues as measurement technique and instrumentation. Rough data and calculation details were often not provided so that the conclusions could not be
    checked easily. The most serious problem was the estimated time that musicians performed in the orchestra. This information is crucial for the calculation of the normalized noise exposure levels (L<jats:sub>EX</jats:sub>), and is especially important as orchestra players do not perform year-round nor
    are they exposed to the same noise levels while performing different pieces of music.</jats:p>

    DOI: 10.21091/mppa.2006.4035

    Scopus

  • The adaptive chirplet transform and visual evoked potentials

    Cui, J., Wong, W.

    IEEE Transactions on Biomedical Engineering   53 ( 7 )   1378 - 1384   2006.7   ISSN:0018-9294

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Institute of Electrical and Electronics Engineers ({IEEE})  

    DOI: 10.1109/TBME.2006.873700

    Scopus

  • Recording human evoked potentials that follow the pitch contour of a natural vowel

    Dajani, H.R., Purcell, D., Wong, W., Kunov, H., Picton, T.W.

    IEEE Transactions on Biomedical Engineering   52 ( 9 )   1614 - 1618   2005.9   ISSN:0018-9294

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Institute of Electrical and Electronics Engineers ({IEEE})  

    DOI: 10.1109/TBME.2005.851499

    Scopus

  • Musicians' noise exposure in orchestra pit

    Lee, J., Behar, A., Kunov, H., Wong, W.

    Applied Acoustics   66 ( 8 )   2005.8   ISSN:0003-682X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.apacoust.2004.11.009

    Scopus

  • Fine structure spectrography and its application in speech

    Dajani, H.R., Wong, W., Kunov, H.

    Journal of the Acoustical Society of America   117 ( 6 )   2005.6   ISSN:0001-4966

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>A filterbank-based algorithm for time-varying spectral analysis is proposed. The algorithm, which is an enhanced realization of the conventional spectrogram, consists of hundreds or thousands of highly overlapping wideband filter/detector stages, followed by a peak detector that probes the filter/detector outputs at very short time intervals. Analysis with synthetic modulated signals illustrates how the proposed method demodulates these signals. The resulting spectrogram-like display, referred to as a “fine structure spectrogram,” shows the fine structure of the modulations in substantially higher detail than is possible with conventional spectrograms. Error evaluation is performed as a function of various parameters of a single- and two-component synthetic modulated signal, and of parameters of the analysis system. In speech, the fine structure spectrogram can detect small frequency and amplitude modulations in the formants. It also appears to identify additional significant time-frequency components in speech that are not detected by other methods, making it potentially useful in speech processing applications.</jats:p>

    DOI: 10.1121/1.1896365

    Scopus

  • Time-frequency analysis of visual evoked potentials using chirplet transform

    J. Cui, W. Wong, S. Mann

    Electronics Letters   2005   ISSN:0013-5194

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1049/el:20056712

  • A stochastic model for the detection of coherent motion

    Lee, J., Wong, W.

    Biological Cybernetics   91 ( 5 )   2004.11   ISSN:0340-1200

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s00422-004-0516-0

    Scopus

  • Noise Exposure of Music Teachers

    Behar, A., MacDonald, E., Lee, J., Cui, J., Kunov, H., Wong, W.

    Journal of Occupational and Environmental Hygiene   1 ( 4 )   2004.4   ISSN:1545-9624

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1080/15459620490432178

    Scopus

  • Quantifying Frequency Dependence of Auditory Search

    Shuji Mori, Willy Wong

    Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science   2004   ISSN:1345-3475

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.2114/jpa.23.303

  • Insertion loss testing of active noise reduction headsets using acoustic fixture

    Cui, J., Behar, A., Wong, W., Kunov, H.

    Applied Acoustics   64 ( 10 )   2003.10   ISSN:0003-682X

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0003-682X(03)00067-7

    Scopus

  • Noise exposure of opera orchestra players

    Lee, J., Behar, A., Kunov, H., Wong, W.

    Canadian Acoustics - Acoustique Canadienne   31 ( 3 )   2003   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • A model cochlear partition involving longitudinal elasticity

    Jaffer, T.S.A., Kunov, H., Wong, W.

    Journal of the Acoustical Society of America   112 ( 2 )   2002.8   ISSN:0001-4966

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>This paper addresses the issue of longitudinal stiffness within the cochlea. A one-dimensional model of the cochlear partition is presented in which the resonant sections are coupled by longitudinal elastic elements. These elements functionally represent the aggregate mechanical effect of the connective tissue that spans the length of the organ of Corti. With the plate-like morphology of the cochlear partition in mind, the contribution of longitudinal elasticity to partition dynamics is appreciable, though weak and nonlinear. If the elasticity is considered Hookian then the nonlinearity takes a cubic form. Numerical solutions are presented that demonstrate the compressive nature of the partial differential nonlinear equations and their ability to produce realistic cubic distortion product otoacoustic emissions. Within the framework of this model, some speculations can be made regarding the dynamical function of the phalangeal processes, the sharpness of active cochlear mechanics, and the propogation of pathology along the partition.</jats:p>

    DOI: 10.1121/1.1496078

    Scopus

  • Mathematical Studies of the Information in the Stimulus-Response Matrix

    Sagi, E., Wong, W., Norwich, K.H.

    Journal of Mathematical Psychology   45 ( 1 )   2001.2   ISSN:0022-2496

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1006/jmps.1999.1296

    Scopus

  • Signal processing for a visual hearing aid

    McDonald, E., Kunov, H., Wong, W.

    Canadian Acoustics - Acoustique Canadienne   29 ( 4 )   2001   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • The elastic structure of the cochlear partition

    Jaffer, T.S.A., Kunov, H., Wong, W.

    Canadian Acoustics - Acoustique Canadienne   29 ( 4 )   2001   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • Structure and correlation in the detection of melodic sequences

    Lee, J., Leung, F., Satkunasingham, J., Wong, W., Wong, W.

    Canadian Acoustics - Acoustique Canadienne   29 ( 3 )   2001   ISSN:0711-6659

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • The tissue distribution of tumor necrosis factor-α in rats: A compartmental model

    Keith, M., Norwich, K.H., Wong, W., Jeejeebhoy, K.N.

    Metabolism: Clinical and Experimental   49 ( 10 )   2000.10   ISSN:0026-0495

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1053/meta.2000.9525

    Scopus

  • Tunes and templates

    Wong, W., Barlow, H.

    Nature   404 ( 6781 )   2000.4   ISSN:0028-0836

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/35010196

    Scopus

  • The magical 'wave' seven plus or minus two?

    Wong, W., Mori, S.

    Journal of the Acoustical Society of America   104 ( 1 )   1998.7   ISSN:0001-4966

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>The idea of the magical number seven has been with us for over 40 years now. During this time, it has been studied extensively by both psychologists and other sensory scientists. One might be skeptical about any new results and ask “What more possibly can we say about this topic?” However, in this paper, an attempt is made to refine the interpretation of the magical number by demonstrating that it is not so much a number, but actually a “wave.” That is, independent of both experimental fluctuations and statistical bias, the magical number takes on a continuum of possible values. This prediction, made theoretically, is supported by existing experimental data. While this prediction does not amount to any significant change to the understanding of the magical number, it may however provide a criterion to judge the acceptability of any theory that purports to explain the magical number phenomenon.</jats:p>

    DOI: 10.1121/1.423296

    Scopus

  • A conceptual approach to the magical number 7

    Wong, W., Mori, S.

    Biological Cybernetics   78 ( 5 )   1998.6   ISSN:0340-1200

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s004220050442

    Scopus

  • Range as a factor determining the information of loudness judgments: Overcoming small sample bias.

    Kenneth H. Norwich, Willy Wong, Elad Sagi

    Canadian Journal of Experimental Psychology / Revue canadienne de psychologie expérimentale   1998.6   ISSN:1878-7290

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1037/h0087281

  • Simulation of human sensory performance

    Wong, W., Norwich, K.H.

    BioSystems   43 ( 3 )   1997.8   ISSN:0303-2647

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/S0303-2647(97)00040-3

    Scopus

  • Unification of psychophysical phenomena: The complete form of Fechner's law

    Norwich, K.H., Wong, W.

    Perception and Psychophysics   59 ( 6 )   1997.1   ISSN:0031-5117

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.3758/BF03205509

    Scopus

  • Sensory function in extraterrestrial beings

    Norwich, K.H., Wong, W.

    Annales de la Fondation Louis de Broglie   22 ( 2 )   1997   ISSN:0182-4295

     More details

    Publishing type:Research paper (scientific journal)  

    Scopus

  • Erratum: Obtaining equal loudness contours from Weber fractions (Journal of the Acoustical Society of America (1995) 97 (3761-3767))

    Wong, W., Norwich, K.H.

    Journal of the Acoustical Society of America   99 ( 5 )   1996   ISSN:0001-4966

     More details

    Publishing type:Research paper (scientific journal)  

    DOI: 10.1121/1.415225

    Scopus

  • Obtaining equal loudness contours from Weber fractions

    Wong, W., Norwich, K.H.

    Journal of the Acoustical Society of America   97 ( 6 )   1995.6   ISSN:0001-4966

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    <jats:p>An empirical equation from Riesz’s classic study on difference thresholds is treated in a new manner. Reformulating the expression for the Weber fraction allows one to account for the shape of the loudness function at different frequencies. Furthermore, the emerging loudness function unifies both the commonly used power and logarithmic laws of sensation. In principle, equal loudness contours can be derived from Riesz’s data. While the derived contours are imperfect, the theoretical method provides a basis for further experimental work.</jats:p>

    DOI: 10.1121/1.412391

    Scopus

  • A universal model of single-unit sensory receptor action

    Norwich, K.H., Wong, W.

    Mathematical Biosciences   125 ( 1 )   83 - 108   1995.1   ISSN:0025-5564

     More details

    Language:English   Publishing type:Research paper (scientific journal)   Publisher:Elsevier {BV}  

    DOI: 10.1016/0025-5564(94)00024-T

    Scopus

  • Density fluctuation in Brownian motion and its significance in olfaction

    Aebersold, B., Norwich, K.H., Wong, W.

    Mathematical and Computer Modelling   18 ( 5 )   1993.9   ISSN:0895-7177

     More details

    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/0895-7177(93)90130-Q

    Scopus

▼display all

Books

  • Advances in Modern Mental Chronometry

    Medina, José M, Wong, Willy, Diaz, José A, Colonius, Hans( Role: Joint editor)

    Frontiers Media SA.  2015.5    ISBN:9782889195664

  • "Visual Evoked Potential Analysis Using Adaptive Chirplet Transform" in Advanced biosignal processing

    Cui, Jie, Wong, Willy( Role: Joint author)

    Springer  2009    ISBN:9783540895053

     More details

    Total pages:xvi, 378 p.   Language:English  

    CiNii Books

  • Fechner day 2007 : proceedings of the 23rd annual meeting of the international society for psychophysics Tokyo, Japan

    Mori, Shuji, Miyaoka, Tetsu, Wong, Willy( Role: Joint editor)

    Kijima Printing  2007 

     More details

    Total pages:xii, 532 p.   Language:English  

    CiNii Books

Presentations

  • Trial-oriented reconstruction on tree optimization (TORONTO): A data-driven method for fast and precise estimation of visual fields

    Runjie Bill Shi, Yan Li, Moshe Eizenman, Willy Wong

    Association for Research in Vision and Ophthalmology  2023.5 

     More details

    Event date: 2023.5

  • Use of spatial filters for improved detection of glaucomatous visual field progression

    Yan Li, Runjie Bill Shi, Willy Wong, Yvonne Buys, Graham E Trope, Moshe Eizenman

    Association for Research in Vision and Ophthalmology  2022.5 

  • Novel home monitoring of visual fields with the Toronto portable perimeter

    R. Shi, R. Saha, Y. Li, W. Wong, Y. Buys, G. Trope, M. Eizenman

    Association for Research in Vision and Ophthalmology  2021.5 

  • From gap detection to gap discrimination: Experiments and extension of mathematical model

    Shuji Mori, Cho Hyunsoo, Wong Willy

    Acoustical Society of Japan  2023.3 

  • An inequality governing the peripheral auditory activity

    Shuji Mori, Willy Wong

    Acoustical Society of Japan  2022.9 

  • A universal theory of the sensory response requiring no free parameters

    Willy Wong

    American Physical Society  2023.3 

  • A universal law of sensory adaptation

    Willy Wong

    Bernstein Conference  2000.10 

▼display all