Updated on 2025/08/19

Information

 

写真a

 
LERKSAIPHENG PAKAWIT
 
Organization
Faculty of Pharmaceutical Sciences Department of Chemo-Pharmaceutical Sciences Assistant Professor
School of Pharmaceutical Sciences Department of General Pharmaceutical Sciences（Concurrent）
Title
Assistant Professor
Contact information
メールアドレス
Tel
092-642-6624
Homepage

Research Areas

  • Life Science / Pathological biochemistry

Degree

  • Ph.D. (Pharmacology) （ 2024.5 Mahidol University ）

Research History

  • Kyushu University  Assistant Professor 

    2024.12 - Present

    　 More details

    Country：Japan

Education

  • Mahidol University   Pharmacology   Doctor of Philosophy in Pharmacology (International Program)

    2020.1 - 2024.5

    　 More details

    Country：Thailand

  • Mahidol University   Pharmacology   Master of Science in Pharmacology (International Program)

    2017.8 - 2019.11

    　 More details

    Country：Thailand

Research Interests・Research Keywords

  • Research theme： Proposed methods for predicting and preventing complications in thalassemia using clinical patients and animal models

    Keyword： Thalassemia, Iron overload, Lipid peroxidation, Lipid radicals, Oxidized cholesteryl esters, Oxidized lipoproteins

    Research period： 2024.12 - Present

Papers

  • Lipid radicals and oxidized cholesteryl esters in low- and high-density lipoproteins in patients with β-thalassemia: Effects of iron overload and iron chelation therapy Reviewed

    Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Luechapudiporn R, Yamada KI, Morales NP

    Free Radical Biology and Medicine   224   618 - 629   2024.11

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    Iron overload results in lipid peroxidation (LPO) and the oxidative modification of circulating lipoproteins, which contributes to cardiovascular complications in patients with β-thalassemia. Investigating LPO may provide opportunities for the development of novel therapeutic strategies; however, the chemical pathways underlying iron overload-induced LPO in β-thalassemia lipoproteins remain unclear. In this study, we identified various species of lipid radicals (L•), the key mediators of LPO, and oxidized cholesteryl esters (oxCE) derived from the in vitro oxidation of major core lipids, cholesteryl linoleate (CE18:2) and cholesteryl arachidonate (CE20:4); the levels of these radical products in low-density lipoproteins (LDL) and high-density lipoproteins (HDL) were measured and compared between β-thalassemia patients and healthy subjects by using a specific fluorescent probe for L• with a liquid chromatography-tandem mass spectrometric method. Our results demonstrated that iron overload substantially decreased the levels of CE18:2 and CE20:4 substrates and α-tocopherol, resulting in higher levels of full-length and short-chain truncated L• and oxCE products. In particular, CE epoxyallyl radicals (•CE-O) were observed in the lipoproteins of β-thalassemia, revealing the pathological roles of iron overload in the progression of LPO. In addition, we found that intermission for two weeks of iron chelators can increase the production of these oxidized products; therefore, suggesting the beneficial effects of iron chelators in preventing LPO progression. In conclusion, our findings partly revealed the primary chemical pathway by which the LPO of circulating lipoproteins is influenced by iron overload and affected by iron chelation therapy. Moreover, we found that •CE + O shows potential as a sensitive biomarker for monitoring LPO in individuals with β-thalassemia.

    DOI： 10.1016/j.freeradbiomed.2024.09.026

  • Kinetics of lipid radical formation in lipoproteins from β-thalassemia: Implication of cholesteryl esters and α-tocopherol Reviewed International coauthorship

    Lerksaipheng P, Paiboonsukwong K, Sanvarinda P, Leuchapudiporn R, Yamada KI, Morales NP

    Biomedicine & Pharmacotherapy   154 ( 113624 )   2022.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.biopha.2022.113624

Presentations

  • 酸化リン脂質受容GPCRの同定と機能解析

    小櫻英翔、上野亮哉、岩本竜弥、加藤俊治、仲川清隆、森本和志、阿部真紗美、Lerksaipheng Pakawit、Jutanom Mirinthorn、山田健一

    R7年度日本生化学会九州支部会　  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：宮崎   Country：Japan  

  • 核内受容体を活性化する酸化リン脂質の探索

    小副川理、森本和志、小櫻英翔、Lerksaipheng Pakawit、阿部真紗美、Jutanom Mirinthorn、山田健一

    R7年度日本生化学会九州支部会　  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：宮崎   Country：Japan  

  • リソソームにおける脂質過酸化を起点としたフェロトーシス実行機構と膜修復過程の解析

    福山翔太、斎元祐真、陣内優佳、森本和志、阿部真紗美、Pakawit Lerksaipheng、唐澤悟、平山祐、Jutanom Mirinthorn、山田健一

    R7年度日本生化学会九州支部会　  2025.6 

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    Event date： 2025.6

    Language：Japanese   Presentation type：Poster presentation  

    Venue：宮崎   Country：Japan  

Professional Memberships

Research Projects

Educational Activities

  • - Proposed methods for predicting and preventing complications in thalassemia using clinical patients and animal models (December 2024 - Present)
    - Identification of lipid radicals derived from iron overload-induced LDL and HDL oxidation in β-thalassemia (January 2020 - May 2024)
    - Investigation of lipid radicals derived from LDL and HDL oxidation in β-thalassemia (2017 August - 2019 November)

Class subject

  • 専門英語

    2025.1   Fall quarter

FD Participation

  • 2025.4   Role：Participation   Title：令和７年度第１回全学FD（新任教員の研修）

    Organizer：University-wide

Teaching Student Awards

  • 優秀ポスター賞

    Year and month of award：2025.6

    Classification of award-winning students：Doctoral student   Name of award-winning student：小櫻　英翔

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    酸化リン脂質受容GPCRの同定と機能解析

  • 優秀ポスター賞

    Year and month of award：2025.6

    Classification of award-winning students：Postgraduate student   Name of award-winning student：福山　翔太

    　 More details

    リソソームにおける脂質過酸化を起点としたフェロトーシス実行機構と膜修復過程の解析

Acceptance of Foreign Researchers, etc.

  • Khon Kaen University

    Acceptance period： 2025.6 - 2025.9   （Period）：1 month or more

    Nationality：Thailand

    Business entity：Ministry of education

  • Mahidol University

    Acceptance period： 2025.5 - 2025.8   （Period）：1 month or more

    Nationality：Thailand

  • Mahidol University

    Acceptance period： 2025.5 - 2025.8   （Period）：1 month or more

    Nationality：Thailand