記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：International Journal of Obesity  

Background: Sympathetic activation of brown adipose tissue (BAT) thermogenesis can ameliorate obesity and related metabolic abnormalities. However, crucial subtypes of the β-adrenergic receptor (AR), as well as effects of its genetic variants on functions of BAT, remains unclear in humans. We conducted association analyses of genes encoding β-ARs and BAT activity in human adults. Methods: Single nucleotide polymorphisms (SNPs) in β1-, β2-, and β3-AR genes (ADRB1, ADRB2, and ADRB3) were tested for the association with BAT activity under mild cold exposure (19 °C, 2 h) in 399 healthy Japanese adults. BAT activity was measured using fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT). To validate the results, we assessed the effects of SNPs in the two independent populations comprising 277 healthy East Asian adults using near-infrared time-resolved spectroscopy (NIRTRS) or infrared thermography (IRT). Effects of SNPs on physiological responses to intensive cold exposure were tested in 42 healthy Japanese adult males using an artificial climate chamber. Results: We found a significant association between a functional SNP (rs1042718) in ADRB2 and BAT activity assessed with FDG-PET/CT (p < 0.001). This SNP also showed an association with cold-induced thermogenesis in the population subset. Furthermore, the association was replicated in the two other independent populations; BAT activity was evaluated by NIRTRS or IRT (p < 0.05). This SNP did not show associations with oxygen consumption and cold-induced thermogenesis under intensive cold exposure, suggesting the irrelevance of shivering thermogenesis. The SNPs of ADRB1 and ADRB3 were not associated with these BAT-related traits. Conclusions: The present study supports the importance of β2-AR in the sympathetic regulation of BAT thermogenesis in humans. The present collection of DNA samples is the largest to which information on the donor’s BAT activity has been assigned and can serve as a reference for further in-depth understanding of human BAT function. (Figure presented.)

DOI： 10.1038/s41366-024-01522-6

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PubMed

担当区分：筆頭著者   記述言語：日本語   掲載種別：研究論文（大学，研究機関等紀要）  

記述言語：日本語   出版者・発行元：日本計算機統計学会  

避難所生活を想像させる教育的介入によって, 避難所への注意反応が変化するのかを検討した. 具体的には, タブレットを用いて避難所生活を想像させる条件と他者と対話しながら避難所生活を想像させる条件を実施し, その介入前後に避難所画像を呈示し, その際のP3a及びP3bを検討した. その結果, 「介入前」よりも「介入後」の方が有意に大きいP3a振幅が得られた. これは介入したことにより避難所画像が被験者にとって重要な刺激となり, 注意資源をより多く割り当てたためであると考えられる. さらに, 避難所に対する注意反応の個人差を検討するために, P3a及びP3bと共感特性との相関関係を調べた. その結果, 認知的共感性が高い人ほど他者と対話しながら避難所生活を想像させると, P3a振幅が大きくなることを示した. このことから, 共感性が高い人にとっては, 他者と対話しながら避難所生活を想像するという教育的介入は, 避難所への注意の誘因となることが示唆された.

DOI： 10.20551/jscswabun.37.2_99

CiNii Research

担当区分：筆頭著者,　最終著者,　責任著者   記述言語：英語   出版者・発行元：Scientific Reports  

Correction to: Scientific Reports, published online 04 August 2023 The original version of this Article contained an error in Figure 2 where the data for Aldosterone (pg/mL) was incorrect. The original Figure 2 and accompanying legend appear below. (Figure presented.) Individual changes in blood components and cytokines. Each color corresponds to an individual subject. After HH, aldosterone and cortisol are significantly decreased (p < 0.05) and WBC count, IL-6 and IL-8 are significantly increased (p < 0.05). The original Article has been corrected.

DOI： 10.1038/s41598-023-40794-2

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PubMed

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Scientific Reports  

When lowlanders are exposed to environments inducing hypobaric hypoxia (HH) such as high mountains, hemodynamic changes occur to maintain oxygen levels in the body. However, changes to other physiological functions under such conditions have yet to be clarified. This study investigated changes in endocrine, inflammatory and immune parameters and individual differences during acute HH exposure using a climatic chamber (75 min of exposure to conditions mimicking 3500 m) in healthy lowlanders. Aldosterone and cortisol were significantly decreased and interleukin (IL)-6, IL-8 and white blood cell (WBC) counts were significantly increased after HH. Lower peripheral oxygen saturation (SpO2) was associated with higher IL-6 and WBC counts, and higher IL-8 was associated with higher cortisol. These findings suggest that endocrine, inflammatory and immune responses are evoked even with a short 75-min exposure to HH and individuals with lower SpO2 seemed to show more pronounced responses. Our results provide basic data for understanding the physiological responses and interactions of homeostatic systems during acute HH.

DOI： 10.1038/s41598-023-39894-w

Web of Science

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PubMed

開催年月日： 2025年10月

会議種別：口頭発表（一般）  

開催年月日： 2025年5月

会議種別：口頭発表（一般）  

開催年月日： 2025年5月

会議種別：ポスター発表  

開催年月日： 2024年6月

会議種別：ポスター発表  

開催年月日： 2024年6月

会議種別：口頭発表（一般）  

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