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Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Physiological Anthropology  

INTRODUCTION: The degrees of subjective intoxication (SI) and vigilance impairment following alcohol consumption vary among individuals. This variability may reflect both metabolic enzyme genotypes and drinking behavior. The purpose of this study was to examine the integrated associations among alcohol-metabolizing enzyme genotypes, drinking tendency, and acute alcohol-induced changes in breath alcohol concentration (BrAC), SI, and vigilance performance. METHODS: Alcohol (0.5 g/kg body weight) was orally administered to 93 healthy adults. BrAC, SI, and the Psychomotor Vigilance Task (PVT) were measured at multiple time points between 0 and 100 min. Repeated-measures ANOVA was performed with time as the within-subject factor and alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes as between-subject factors. Additionally, using structural equation modeling (SEM), we examined how BrAC, SI, and PVT lapse rates were jointly related to genotypes and the Alcohol Use Disorders Identification Test-Consumption (AUDIT-C) score. RESULTS: For BrAC and SI, a significant ALDH2 × time interaction was observed. ALDH2*1/*1 participants had lower BrAC than ALDH2*1/*2 participants. Regarding PVT performance, the main effect of time was observed, but no significant main effects or interactions involving genotypes were found. Additionally, results from SEM showed that, in the 40-min model, BrAC positively predicted SI and lapse rate, and AUDIT-C negatively predicted SI but not lapse rate. ALDH2 genotype positively predicted AUDIT-C and negatively predicted BrAC; ALDH2 genotype also showed a significant direct negative path to SI but not on lapse rate. In the 100-min model, BrAC positively predicted SI but not lapse rate, and AUDIT-C negatively predicted SI but not lapse rate. CONCLUSION: ALDH2 genotype contributed to variability in BrAC and SI but not PVT performance. In the 40-min SEM model, higher AUDIT-C predicted lower SI despite no association with BrAC or PVT lapse rate. This pattern suggests a discrepancy between self-reported intoxication and PVT performance. These findings may inform risk communication and intervention strategies to reduce alcohol-related accidents and improve health education. TRIAL REGISTRATION: UMIN Clinical Trials Registry (UMIN-CTR), UMIN000055964, registered on 2024-10-28.

DOI： 10.1186/s40101-026-00434-w

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Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of Physiological Anthropology  

Background: Previous studies have reported that the sense of “self” is associated with specific brain regions and neural network activities. In addition, the mirror system, which functions when executing or observing an action, might contribute to differentiating the self from others and form the basis of the sense of self as a fundamental physical representation. This study investigated whether differences in mu suppression, an indicator of mirror system activity, reflect cognitions related to self-other discrimination. Methods: The participants were 30 of healthy college students. The participants observed short video clips of hand movements performed by themselves or actors from two perspectives (i.e., first-person and third-person). The electroencephalogram (EEG) mu rhythm (8–13 Hz) was measured during video observation as an index of mirror neuron system activity. EEG activity related to self-detection was analyzed using participants’ hand movements as self-relevant stimuli. Results: The results showed that mu suppression in the 8–13-Hz range exhibited perspective-dependent responses to self/other stimuli. There was a significant self-oriented mu suppression response in the first-person perspective. However, the study found no significant response orientation in the third-person perspective. The results suggest that mirror system activity may involve self-other discrimination differently depending on the perspective. Conclusions: In summary, this study examined the mirror system’s activity for self and others using the EEG’s mu suppression. As a result, it was suggested that differences in self and others or perspectives may influence mu suppression.

DOI： 10.1186/s40101-024-00369-0

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DOI： 10.20718/jjpa.26.3_63

DOI： 10.1096/fasebj.2021.35.S1.05454

DOI： https://doi.org/10.1111/opo.12809

Event date： 2025.12

Language：Japanese   Presentation type：Public lecture, seminar, tutorial, course, or other speech  

Venue：京都  

Event date： 2026.9

Presentation type：Poster presentation  

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Event date： 2026.9

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Event date： 2026.4

Presentation type：Poster presentation  

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Event date： 2025.12

Language：Japanese   Presentation type：Poster presentation  

Venue：東京  

Language：Japanese   Publisher：日本生理心理学会  

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