ATARASHI NAOKO
Organization
Faculty of Medical Sciences Department of Basic Medicine Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
External link
Research Areas
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Life Science / Bacteriology
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Life Science / Immunology
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Life Science / Cell biology
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Life Science / Molecular biology
Degree
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博士（医学） （ 2010.3 Osaka University ）
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修士（理学） （ 2006.3 Kyushu University ）
Research History
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国立研究開発法人 理化学研究所 生命医科学研究センター テクニカルスタッフI
2015.7 - 2025.3
Country：Japan
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日本学術振興会 特別研究員 PD
2011.4 - 2015.6
Country：Japan
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The University of Tokyo 医学系研究科 特任研究員
2010.4 - 2011.3
Country：Japan
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日本学術振興会 特別研究員 DC2
2008.4 - 2010.3
Education
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Osaka University 大学院医学系研究科 予防環境医学専攻
2006.4 - 2010.3
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Kyushu University 大学院システム生命科学府 システム生命科学専攻
2004.4 - 2006.3
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Kyushu University 理学部 生物学科
2000.4 - 2004.3
Research Interests・Research Keywords
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Research theme： Identification and Functional Analysis of Gut Bacteria Contributing to the Suppression of Enterohemorrhagic Escherichia coli O157 Infection
Keyword： O157, 腸内細菌叢, O157感染症モデルマウス
Research period： 2025.4 - Present
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Research theme： Elucidation of the Functional Roles of Apoptosis and Organelle Morphological Changes During Dendritic Cell Maturation
Keyword： 樹状細胞、オルガネラ、アポトーシス
Research period： 2011.4 - 2015.6
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Research theme： Elucidation of Molecular Mechanisms in the Late Stage of Autophagosome Formation
Keyword： オートファジー, PI3K, 脱リン酸化酵素, MTMR3
Research period： 2006.4 - 2010.3
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Research theme： Elucidation of Molecular Mechanisms Regulating Mitochondrial Morphological Changes During Cell Cycle Progression
Keyword： ミトコンドリア, 形態変化, Drp1, 細胞周期, リン酸化
Research period： 2003.4 - 2006.3
Papers
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Changes in the intestinal microbiota of Japanese children during the first 3.5 years of life Reviewed
Tsuruoka Y, Kato T, Watanabe M, Taguchi-Atarashi N, Ohno H, Mori C, Sakurai K.
Sci Rep. 14 ( 1 ) 29302 2024.12
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Food antigens suppress small intestinal tumorigenesis. Reviewed International journal
Sasaki T, Ota Y, Takikawa Y, Terrooatea T, Kanaya T, Takahashi M, Taguchi-Atarashi N, Tachibana N, Yabukami H, Surh CD, Minoda A, Kim KS, Ohno H.
Front Immunol. 15 1373766 2024.9
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Association of the Maternal Gut Microbiota/Metabolome with Cord Blood CCL17. Reviewed International journal
Tanabe H, Sakurai K, Nakanishi Y, Kato T, Kawasaki Y, Nakano T, Yamaide F, Taguchi-Atarashi N, Shiko Y, Takashima I, Watanabe M, Ochiai S, Ohno H, Fukuoka H, Shimojo N, Mori C.
Nutrients. 13 ( 8 ) 2837 2021.8
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Corrigendum to "Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort" [World Allergy Organ J 12/10 (2019) 100065]. Reviewed International journal
Tanabe H, Sakurai K, Kato T, Kawasaki Y, Nakano T, Yamaide F, Taguchi-Atarashi N, Watanabe M, Ochiai S, Ohno H, Fukuoka H, Shimojo N, Mori C.
World Allergy Organ J. 14 ( 1 ) 100507 2021.1
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Gut microorganisms act together to exacerbate inflammation in spinal cords. Reviewed International journal
Miyauchi E, Kim SW, Suda W, Kawasumi M, Onawa S, Taguchi-Atarashi N, Morita H, Taylor TD, Hattori M, Ohno H.
Nature. 585 ( 7823 ) 102 - 106 2020.8
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Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA. Reviewed International journal
Satoh-Takayama N, Kato T, Motomura Y, Kageyama T, Taguchi-Atarashi N, Kinoshita-Daitoku R, Kuroda E, Di Santo JP, Mimuro H, Moro K, Ohno H.
Immunity. 52 ( 4 ) 635 - 649 2020.4
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Association between gut microbiota composition and glycoalbumin level during pregnancy in Japanese women: Pilot study from Chiba Study of Mother and Child Health Reviewed International journal
Sakurai K, Kato T, Tanabe H, Taguchi-Atarashi N, Sato Y, Eguchi A, Watanabe M, Ohno H, Mori C.
J Diabetes Investig. 11 ( 3 ) 699 - 706 2019.12
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Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort. Reviewed International journal
Tanabe H, Sakurai K, Kato T, Kawasaki Y, Nakano T, Yamaide F, Taguchi-Atarashi N, Watanabe M, Ochiai S, Ohno H, Fukuoka H, Shimojo N, Mori C.
World Allergy Organ J. 12 ( 10 ) 100065 2019.12
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Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice. Reviewed International journal
Yanai H, Chiba S, Hangai S, Kometani K, Inoue A, Kimura Y, Abe T, Kiyonari H, Nishio J, Taguchi-Atarashi N, Mizushima Y, Negishi H, Grosschedl R, Taniguchi T.
Proc Natl Acad Sci U S A. 115 ( 20 ) 5253 - 5258 2018.5
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Beneficial innate signaling interference for antibacterial responses by a Toll-like receptor-mediated enhancement of the MKP-IRF3 axis. Reviewed International journal
Negishi H, Matsuki K, Endo N, Sarashina H, Miki S, Matsuda A, Fukazawa K, Taguchi-Atarashi N, Ikushima H, Yanai H, Nishio J, Honda K, Fujioka Y, Ohba Y, Noda T, Taniguchi S, Nishida E, Zhang Y, Chi H, Flavell RA, Taniguchi T.
Proc Natl Acad Sci U S A. 110 ( 49 ) 19884 - 19889 2013.12
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Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction. Reviewed International journal
Negishi H, Miki S, Sarashina H, Taguchi-Atarashi N, Nakajima A, Matsuki K, Endo N, Yanai H, Nishio J, Honda K, Taniguchi T.
Proc Natl Acad Sci U S A. 109 ( 51 ) 21016 - 21021 2012.12
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Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Reviewed International journal
Taguchi-Atarashi N, Hamasaki M, Matsunaga K, Omori H, Ktistakis NT, Yoshimori T, Noda T.
Traffic. 11 ( 4 ) 468 - 478 2010.4
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Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Reviewed International journal
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K.
Nat Cell Biol. 11 ( 8 ) 958 - 966 2009.8
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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. Reviewed International journal
Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K.
J Biol Chem. 282 ( 15 ) 11521 - 11529 2007.4
MISC
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Regulation of membrane biogenesis in autophagy via PI3P dynamics. Reviewed
Noda T, Matsunaga K, Taguchi-Atarashi N, Yoshimori T.
Semin Cell Dev Biol. 21 ( 7 ) 671 - 676 2010.9
Research Projects
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腸管出血性大腸菌O157の感染抑制に寄与する腸内細菌の単離・同定
Grant number：25K23826 2025.7 - 2027.3
Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up
新 奈緒子
Grant type：Scientific research funding
腸管出血性大腸菌O157の感染による食中毒は、溶血性尿毒症症候群（HUS）など深刻な合併症を発症するリスクの高い感染症である。このため、感染初期段階において積極的かつ有効な治療を施すことが重要であるが、現在の治療は主に対処療法に依存しており、積極的な治療法の開発は急務である。
今回申請者は、ヒトとマウスからO157の感染抑制に寄与する腸内細菌の単離・同定を計画している。本研究の遂行により、どの腸内細菌がどのようなメカニズムで感染を抑制するのか解明することで、O157感染症の新規治療法や治療薬、予防法の開発を目指す。 -
樹状細胞成熟過程におけるアポトーシスやオルガネラ形態変化の役割 研究課題
Grant number：11J05380 2011.4 - 2015.6
日本学術振興会(JSPS) 科学研究費助成事業 特別研究員奨励費 (PD)
Authorship：Principal investigator Grant type：Scientific research funding
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オートファゴソーム形成後期課程における分子機構の解析 研究課題
Grant number： 08J03321 2008.4 - 2010.3
日本学術振興会(JSPS) 科学研究費助成事業 特別研究員奨励費 (DC2)
Authorship：Principal investigator Grant type：Scientific research funding
Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.
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2025 国立研究開発法人 理化学研究所 Domestic/International Classification:Japan