Updated on 2025/09/04

Information

 

写真a

 
KUBOTA RYO
 
Organization
Faculty of Engineering Department of Applied Chemistry Professor
School of Engineering （Concurrent）
Graduate School of Engineering （Concurrent）
Title
Professor

Research Areas

  • Nanotechnology/Materials / Structural organic chemistry and physical organic chemistry

  • Nanotechnology/Materials / Polymer materials

Awards

  • ヤングサイエンティスト講演賞

    2023.7   高分子学会関西支部   超分子–高分子複合ヒドロゲルのその場構造観察と機能開拓

    窪田 亮

Papers

  • A minimalist design approach to simple coacervates from low-molecular-weight components Invited Reviewed International journal

    Ryou Kubota

    Polymer Journal   57 ( 8 )   815 - 829   2025.5   （ ISSN:0032-3896 eISSN:1349-0540 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Polymer Journal  

    Coacervates are condensed, liquid-like assemblies formed through liquid–liquid phase separation via associative interactions among molecular components. Owing to their membraneless nature, coacervates exhibit unique dynamic features, such as coalescence and molecular sequestration, thus serving as promising platforms for drug delivery and the regulation of biological events. In this Focus Review, representative examples of simple coacervates composed of phase-separating low-molecular-weight molecules (LMWMs) are highlighted. This review provides a minimalist design strategy for LMWM-based simple coacervates based on surfactants and peptides and summarizes their unique functions, including stimulus-responsive structural transformations. The sophisticated design of these droplets is expected to enable a wide range of applications, including studies on the origins of life, the development of artificial cells, intracellular and in vivo protein delivery, biosensing, and molecular computing.

    DOI： 10.1038/s41428-025-01037-5

    Web of Science

    Scopus

  • Emergence of Dynamic Instability by Hybridizing Synthetic Self-Assembled Dipeptide Fibers with Surfactant Micelles Reviewed International journal

    Shogo Torigoe, Kazutoshi Nagao, Ryou Kubota, Itaru Hamachi

    Journal of the American Chemical Society   146 ( 9 )   5799 - 5805   2024.2   （ ISSN:00027863 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Journal of the American Chemical Society  

    Supramolecular chemistry currently faces the challenge of controlling nonequilibrium dynamics such as the dynamic instability of microtubules. In this study, we explored the emergence of dynamic instability through the hybridization of peptide-type supramolecular nanofibers with surfactant micelles. Using real-time confocal imaging, we discovered that the addition of micelles to nanofibers induced the simultaneous but asynchronous growth and shrinkage of nanofibers during which the total number of fibers decreased monotonically. This dynamic phenomenon unexpectedly persisted for 6 days and was driven not by chemical reactions but by noncovalent supramolecular interactions between peptide-type nanofibers and surfactant micelles. This study demonstrates a strategy for inducing autonomous supramolecular dynamics, which will open up possibilities for developing soft materials applicable to biomedicine and soft robotics.

    DOI： 10.1021/jacs.3c14565

    Scopus

  • Cell‐Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non‐/Out‐of‐Equilibrium Dynamic Systems Reviewed International journal

    Ryou Kubota, Itaru Hamachi

    Advanced Science   11 ( 8 )   2024.2

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Advanced Science  

    Living cells are complex, nonequilibrium supramolecular systems capable of independently and/or cooperatively integrating multiple bio-supramolecules to execute intricate physiological functions that cannot be accomplished by individual biomolecules. These biological design strategies offer valuable insights for the development of synthetic supramolecular systems with spatially controlled hierarchical structures, which, importantly, exhibit cell-like responses and functions. The next grand challenge in supramolecular chemistry is to control the organization of multiple types of supramolecules in a single system, thus integrating the functions of these supramolecules in an orthogonal and/or cooperative manner. In this perspective, the recent progress in constructing multicomponent supramolecular soft materials through the hybridization of supramolecules, such as self-assembled nanofibers/gels and coacervates, with other functional molecules, including polymer gels and enzymes is highlighted. Moreover, results show that these materials exhibit bioinspired responses to stimuli, such as bidirectional rheological responses of supramolecular double-network hydrogels, temporal stimulus pattern-dependent responses of synthetic coacervates, and 3D hydrogel patterning in response to reaction–diffusion processes are presented. Autonomous active soft materials with cell-like responses and spatially controlled structures hold promise for diverse applications, including soft robotics with directional motion, point-of-care disease diagnosis, and tissue regeneration.

    DOI： 10.1002/advs.202306830

    Scopus

  • Supramolecular–Polymer Composite Hydrogels: From <i>In Situ</i> Network Observation to Functional Properties Reviewed International journal

    Ryou Kubota

    Bulletin of the Chemical Society of Japan   96 ( 8 )   802 - 812   2023.8   （ ISSN:0009-2673 eISSN:1348-0634 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：The Chemical Society of Japan  

    Living cells and organisms are composed of numerous biomolecules and control their concentrations and spatial distribution in a spatiotemporal manner to exhibit intricate biological functions. Inspired by the extracellular matrix, synthetic multi-network hydrogels have attracted attention due to their remarkable properties like extremely high toughness. This account summarizes our research progress on one emerging class of the multi-network hydrogels, supramolecularpolymer composite hydrogel. Composite hydrogels can rationally integrate stimulus response of supramolecular gels and stiffness of polymer gels. Super-resolution microscopy visualizes four types of network patterns at the µm scale: an orthogonal and three interactive networks, which may influence the viscoelastic properties of composite hydrogels. We found a kind of composite hydrogel that shows autonomous network remodeling, enabling fracture-induced 3D gel patterning. Furthermore, we demonstrated that supramolecularpolymer composite hydrogels are applicable as a matrix for controlled release of protein biopharmaceuticals in response to antibodies through incorporation of functional molecules such as enzymes and their inhibitors. Supramolecularpolymer composite hydrogels hold promise as the next-generation smart and responsive soft materials for biomedical applications, including tissue engineering and regenerative medicine.

    DOI： 10.1246/bcsj.20230129

    Scopus

  • Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time Reviewed International journal

    Ryou Kubota, Taro Hiroi, Yuriki Ikuta, Yuchong Liu, Itaru Hamachi

    Journal of the American Chemical Society   145 ( 33 )   18316 - 18328   2023.8   （ ISSN:0002-7863 eISSN:1520-5126 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    Coacervates, which are formed by liquid-liquid phase separation, have been extensively explored as models for synthetic cells and membraneless organelles, so their in-depth structural analysis is crucial. However, both the inner structure dynamics and formation mechanism of coacervates remain elusive. Herein, we demonstrate real-time confocal observation of a three-dimensional sponge-like network in a dipeptide-based coacervate. In situ generation of the dipeptide allowed us to capture the emergence of the sponge-like network via unprecedented membrane folding of vesicle-shaped intermediates. We also visualized dynamic fluctuation of the network, including reversible engagement/disengagement of cross-links and a stochastic network kissing event. Photoinduced transient formation of a multiphase coacervate was achieved with a thermally responsive phase transition. Our findings expand the fundamental understanding of synthetic coacervates and provide opportunities to manipulate their physicochemical properties by engineering the inner network for potential applications in development of artificial cells and life-like material fabrication.

    DOI： 10.1021/jacs.3c03793

    Scopus

  • Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions Reviewed International journal

    Keisuke Nakamura, Ryou Kubota, Takuma Aoyama, Kenji Urayama, Itaru Hamachi

    Nature Communications   14 ( 1 )   2023.3   （ eISSN:2041-1723 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    Synthetic composite hydrogels comprising supramolecular fibers and covalent polymers have attracted considerable attention because their properties are similar to biological connective tissues. However, an in-depth analysis of the network structures has not been performed. In this study, we discovered the composite network can be categorized into four distinct patterns regarding morphology and colocalization of the components using in situ, real-time confocal imaging. Time-lapse imaging of the network formation process reveals that the patterns are governed by two factors, the order of the network formation and the interactions between the two different fibers. Additionally, the imaging studies revealed a unique composite hydrogel undergoing dynamic network remodeling on the scale of a hundred micrometers to more than one millimeter. Such dynamic properties allow for fracture-induced artificial patterning of a network three dimensionally. This study introduces a valuable guideline to the design of hierarchical composite soft materials.

    DOI： 10.1038/s41467-023-37412-0

    Scopus

    Other Link： https://www.nature.com/articles/s41467-023-37412-0

  • Temporal Stimulus Patterns Drive Differentiation of a Synthetic Dipeptide-Based Coacervate Reviewed International journal

    Ryou Kubota, Shogo Torigoe, Itaru Hamachi

    Journal of the American Chemical Society   144 ( 33 )   15155 - 15164   2022.8   （ ISSN:0002-7863 eISSN:1520-5126 ）

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    Authorship：Lead author,　Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society (ACS)  

    The fate of living cells often depends on their processing of temporally modulated information, such as the frequency and duration of various signals. Synthetic stimulus-responsive systems have been intensely studied for >50 years, but it is still challenging for chemists to create artificial systems that can decode dynamically oscillating stimuli and alter the systems’ properties/functions because of the lack of sophisticated reaction networks that are comparable with biological signal transduction. Here, we report morphological differentiation of synthetic dipeptide-based coacervates in response to temporally distinct patterns of the light pulse. We designed a simple cationic diphenylalanine peptide derivative to enable the formation of coacervates. The coacervates concentrated an anionic methacrylate monomer and a photoinitiator, which provided a unique reaction environment and facilitated light-triggered radical polymerization-even in air. Pulsed light irradiation at 9.0 Hz (but not at 0.5 Hz) afforded anionic polymers. This dependence on the light pulse patterns is attributable to the competition of reactive radical intermediates between the methacrylate monomer and molecular oxygen. The temporal pulse pattern-dependent polymer formation enabled the coacervates to differentiate in terms of morphology and internal viscosity, with an ultrasensitive switch-like mode. Our achievements will facilitate the rational design of smart supramolecular soft materials and are insightful regarding the synthesis of sophisticated chemical cells.

    DOI： 10.1021/jacs.2c05101

    Scopus

  • Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue Reviewed International journal

    Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura, Hiroshi Nonaka, Seiya Mizuno, Satoru Takahashi, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka

    Nature Communications   13 ( 1 )   3167 - 3167   2022.6

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Nature Communications  

    Direct activation of cell-surface receptors is highly desirable for elucidating their physiological roles. A potential approach for cell-type-specific activation of a receptor subtype is chemogenetics, in which both point mutagenesis of the receptors and designed ligands are used. However, ligand-binding properties are affected in most cases. Here, we developed a chemogenetic method for direct activation of metabotropic glutamate receptor 1 (mGlu1), which plays essential roles in cerebellar functions in the brain. Our screening identified a mGlu1 mutant, mGlu1(N264H), that was activated directly by palladium complexes. A palladium complex showing low cytotoxicity successfully activated mGlu1 in mGlu1(N264H) knock-in mice, revealing that activation of endogenous mGlu1 is sufficient to evoke the critical cellular mechanism of synaptic plasticity, a basis of motor learning in the cerebellum. Moreover, cell-type-specific activation of mGlu1 was demonstrated successfully using adeno-associated viruses in mice, which shows the potential utility of this chemogenetics for clarifying the physiological roles of mGlu1 in a cell-type-specific manner.

    DOI： 10.1038/s41467-022-30828-0

    Scopus

    PubMed

  • Temporal stimulus patterns drive differentiation of a synthetic coacervate Reviewed International journal

    Ryou Kubota and Shogo Torigoe and Itaru Hamachi

    2022.4

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：American Chemical Society ({ACS})  

    DOI： 10.26434/chemrxiv-2022-bp028

  • Shape-selective one-step synthesis of branched gold nanoparticles on the crystal surface of redox-active Pd-II-macrocycles Reviewed International journal

    Yutaro Yamashita, Shohei Tashiro, Yoshiki Ishii, Takayuki Uchihashi, Nobuyuki Matsushita, Ryou Kubota, Mitsuhiko Shionoya

    Dalton Transactions   51 ( 4 )   1318 - 1324   2021.12   （ ISSN:1477-9226 eISSN:1477-9234 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Royal Society of Chemistry ({RSC})  

    The synthesis of branched gold nanoparticles (AuNPs) with shape- and size-specific optical properties requires effective control of the particle formation mechanism using appropriate reducing agents and protective agents that prevent particle aggregation in solution. In this context, the heterogeneous synthesis of AuNPs using solid surfaces of graphene oxides and metal–organic frameworks has attracted much attention. These materials are characterized by their ability to immobilize and stabilize the particles grown on the surface without the need for additional protective agents. However, the shape- and size-selective synthesis of AuNPs using solid surfaces remains challenging. Herein, we report the shape-selective one-step synthesis of monodisperse branched AuNPs using a metal–macrocycle framework (MMF), a porous molecular crystal of PdII3-tris(phenylenediamine) macrocycle. Konpeito-Shaped branched AuNPs with uniform size were obtained on the surface of MMF by mixing HAuCl<inf>4</inf>·4H<inf>2</inf>O, l-ascorbic acid and MMF microcrystals. Spectroscopic and microscopic observations confirmed that MMF promoted the reduction of gold by its reductive activity as well as acted as a solid support to electrostatically immobilize the pseudo-seed particles for further growth on the crystal surface. In addition, the MMF also served as a substrate for in situ high-speed AFM imaging due to the effective immobilization of AuNPs on the surface, allowing direct visualization of the particle growth. Since the chemical structural features of MMF allow the growth of branched AuNPs via pseudo-seeding, this approach would provide new synthetic methods for obtaining a variety of gold nanostructures.

    DOI： 10.1039/d1dt03973c

    Web of Science

    Scopus

  • Phototriggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-Sorting Double Network Hydrogel Reviewed

    Keisuke Nakamura, Wataru Tanaka, Kei Sada, Ryou Kubota, Takuma Aoyama, Kenji Urayama,Itaru Hamachi

    Journal of the American Chemical Society   143   19532 - 19541   2021.11

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/jacs.1c09172

  • Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies Invited Reviewed

    Ryou Kubota, Wataru Tanaka, Itaru Hamachi

    Chemical Reviews   121 ( 22 )   14281 - 12347   2021.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/acs.chemrev.0c01334

  • In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation Reviewed

    Ryou Kubota, Shogo Torigoe, Shuang Liu, Itaru Hamachi

    Chemistry Letters   49 ( 11 )   1319 - 1323   2020.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1246/cl.200513

  • Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers Reviewed

    Ryou Kubota, Kazutoshi Nagao, Wataru Tanaka, Ryotaro Matsumura, Takuma Aoyama, Kenji Urayama, Itaru Hamachi

    Nature Communications   11   4100   2020.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41467-020-17984-x

  • Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems Reviewed

    Hajime Shigemitsu*, Ryou Kubota*, Keisuke Nakamura, Tomonobu Matsuzaki, Saori Minami, Kenji Urayama, Itaru Hamachi

    Nature Communications   11   3859   2020.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41467-020-17698-0

  • Force generation by a propagating wave of supramolecular nanofibers Reviewed

    Ryou Kubota, Masahiro Makuta, Ryo Suzuki, Masatoshi Ichikawa, Motomu Tanaka, Itaru Hamachi

    Nature Communications   11   3541   2020.7

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41467-020-17394-z

  • Face-selective adsorption of a prochiral compound on the chiral pore-surface of a metal–macrocycle framework (MMF) directed towards stereoselective reactions Reviewed

    Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

    Faraday Discussions   225   197 - 209   2020.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/D0FD00019A

  • Core-shell metal-macrocycle framework (MMF): spatially selective dye inclusion through core-to-shell anisotropic transport along crystalline 1D-channels connected by epitaxial growth Reviewed

    Shohei Tashiro, Shinya Mitsui, David W. Burke, Ryou Kubota, Nobuyuki Matsushita, Mitsuhiko Shionoya

    CrystEngComm   22   1306 - 1309   2020.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/D0CE00120A

  • The power of confocal scanning laser microscopy in supramolecular chemistry: in situ real-time imaging of stimuli-responsive multicomponent supramolecular hydrogels Reviewed

    Ryou Kubota, Keisuke Nakamura, Shogo Torigoe, Itaru Hamachi

    ChemistryOpen   9 ( 1 )   67 - 79   2020.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1002/open.201900328

  • pH Nanosensor Using Electronic Spins in Diamond Reviewed

    Takahiro Fujisaku, Ryotaro Tanabe, Shinobu Onoda, Ryou Kubota, Takuya F. Segawa, Frederick T.-K. So, Takeshi Ohshima, Itaru Hamachi, Masahiro Shirakawa, Ryuji Igarashi

    ACS Nano   13 ( 10 )   11726 - 11732   2019.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/acsnano.9b05342

  • On-cell coordination chemistry: chemogenetic activation of membrane-bound glutamate receptors in living cells

    Ryou Kubota, Shigeki Kiyonaka, Itaru Hamachi

    Methods in Enzymology   622   411 - 430   2019.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1016/bs.mie.2019.02.033

  • Post-assembly fabrication of a functional multicomponent supramolecular hydrogel based on a self-sorting double network Reviewed

    Wataru Tanaka, Hajime Shigemitsu, Takahiro Fujisaku, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi

    Journal of the American Chemical Society   141 ( 12 )   4997 - 5004   2019.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/jacs.9b00715

  • Rational synthesis of benzimidazole[3]arenes by CuII catalyzed post-macrocyclization transformation Reviewed

    Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

    Chemical Science   9   7614 - 7619   2018.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/C8SC03086C

  • Chemogenetic approach using Ni(II) complex–agonist conjugates allows selective activation of class A G-protein-coupled receptors Reviewed

    Ryou Kubota, Wataru Nomura, Takuma Iwakasa, Kento Ojima, Shigeki Kiyonaka, Itaru Hamachi

    ACS Central Science   4 ( 9 )   1211 - 1221   2018.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/acscentsci.8b00390

  • Imaging-based study on control factors over self-sorting of supramolecular nanofibers formed from peptide- and lipid-type hydrogelators Invited Reviewed

    Ryou Kubota, Shuang Liu, Hajime Shigemitsu, Keisuke Nakamura, Wataru Tanaka, Masato Ikeda, Itaru Hamachi

    Bioconjugate Chemistry   29 ( 6 )   2058 - 2067   2018.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/acs.bioconjchem.8b00260

  • An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks Reviewed

    Hajime Shigemitsu, Takashiro Fujisaku, Wataru Tanaka, Ryou Kubota, Saori Minami, Kenji Urayama, Itaru Hamachi

    Nature Nanotechnology   13   165 - 172   2018.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/s41565-017-0026-6

  • Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells Reviewed

    Shigeki, Kiyonaka, Ryou Kubota, Yukiko Michibata, Masayoshi Sakakura, Hideo Takahashi, Tomohiro Numata, Ryuji Inoue, Michisuke Yuzaki, Itaru Hamachi

    Nature Chemistry   8   958 - 967   2016.6

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/nchem.2554

  • Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions Reviewed

    Shohei Tashiro, Hirotaka Yonezawa, Ryou Kubota, Tsutomu Umeki, Mitsuhiko Shionoya

    Chemical Communications   52   7657 - 7660   2016.4

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/C6CC02621D

  • In situ real-time imaging of self-sorted supramolecular nanofibres Reviewed

    Shoji Onogi, Hajime Shigemitsu, Tatsuyuki Yoshii, Tatsuya Tanida, Masato Ikeda, Ryou Kubota, Itaru Hamachi

    Nature Chemistry   8   743 - 752   2016.3

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/nchem.2526

  • Chiral Metal-Macrocycle Frameworks: supramolecular chirality induction and helicity inversion of the helical metal-macrocyclic structures Reviewed

    Ryou Kubota, Shohei Tashiro, Mitsuhiko Shionoya

    Chemical Science   7   2217 - 2221   2016.1

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/C5SC04570C

  • Protein recognition using synthetic small-molecular binders toward optical sensing in vitro and in live cells Invited Reviewed

    Ryou Kubota, Itaru Hamachi

    Chemical Society Reviews   44   4454 - 4471   2015.3

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/C4CS00381K

  • In situ X-ray snapshot analysis of transient molecular adsorption in a crystalline channel Reviewed

    Ryou Kubota, Shohei Tashiro, Motoo Shiro, Mitsuhiko Shionoya

    Nature Chemistry   6   913 - 918   2014.8

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1038/nchem.2044

  • Simultaneous arrangement of up to three different molecules on the pore surface of metal-macrocycle framework (MMF): cooperation and competition Reviewed

    Shohei Tashiro, Tsutomu Umeki, Ryou Kubota, Mitsuhiko Shionoya

    Angewandte Chemie International Edition   53 ( 32 )   8310 - 8315   2014.5

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1002/anie.201404179

  • Palladium- or proton-induced submicro spherical aggregation of macrocyclic amphiphiles in aqueous soluiton Reviewed

    Shohei Tashiro, Ryou Kubota, Minori Kawagoe, Mitsuhiko Shionoya

    Dalton Transactions   42   15915 - 15918   2013.8

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1039/C3DT51827B

  • Non-covalent surface modification of metal-macrocycle framework with mono-substituted benzenes Reviewed

    Ryou Kubota, Shohei Tashiro, Tsutomu Umeki, Mitsuhiko Shionoya

    Supramolecular Chemistry   24 ( 12 )   867 - 877   2012.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1080/10610278.2012.733394

  • Metal-macrocycle framework (MMF): supramolecular nano-channel surfaces with shape sorting capability Reviewed

    Shohei Tashiro, Ryou Kubota, Mitsuhiko Shionoya

    Journal of the American Chemical Society   134 ( 5 )   2461 - 2464   2011.12

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： https://doi.org/10.1021/ja209422m

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