記述言語：英語   出版者・発行元：Journal of Psychiatric Research  

Despite recent studies suggesting an important association of hoarder disorder (HD) and attention-deficit/hyperactive disorder (ADHD), no neuroimaging study has investigated the differences between patients with HD comorbid with ADHD and those without ADHD. This study investigated the regional spontaneous activity and functional connectivity in HD, focusing on the comorbidity with ADHD. Resting-state functional magnetic resonance imaging (MRI) data were obtained from 24 patients with HD and 31 healthy individuals. We investigated the group differences using the fractional amplitude of low-frequency fluctuation (fALFF). The altered regions in the fALFF were used as seeds in a functional connectivity analysis where we conducted group comparisons among the three groups: healthy controls (HCs), HD with ADHD (HD +ADHD), and HD without ADHD (HD -ADHD). Compared to HCs, patients with HD had a reduced fALFF in the right inferior frontal gyrus (IFG). Functional connectivity analysis revealed that patients with HD + ADHD had reduced functional connectivity between the IFG and dorsolateral prefrontal cortex (DLPFC) compared to HCs, while the HD -ADHD group was intermediate level between HD +ADHD and HCs groups. In conclusion, patients with HD have altered spontaneous activity of the IFG. Additionally, patients with HD + ADHD had significantly reduced functional connectivity between the IFG and the DLPFC. Our findings suggest the potential need to distinguish between subgroups of HD+ADHD to identify novel neurobiological models of HD that could guide future therapeutic strategies.

DOI： 10.1016/j.jpsychires.2025.03.055

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PubMed

記述言語：英語   出版者・発行元：Psychiatry Research Neuroimaging  

Obsessive-compulsive disorder (OCD) is characterized by structural alteration within white matter tissues of cortico-striato-thalamo-cortical, temporal and occipital circuits. However, the presence of microstructural changes in the white matter tracts of unaffected first-degree relatives of patients with OCD as a vulnerability marker remains unclear. Therefore, here, diffusion-tensor magnetic resonance imaging (DTI) data were obtained from 29 first-degree relatives of patients with OCD and 59 healthy controls. We investigated the group differences in FA using whole-brain analysis (DTI analysis). For additional regions of interest (ROI) analysis, we focused on the posterior thalamic radiation and sagittal stratum, shown in recent meta-analysis of patients with OCD. In both whole-brain and ROI analyses, using a strict statistical threshold (family-wise error rate [FWE] corrected p<.05 for whole-brain analyses, and p<.0125 (0.05/4) with Bonferroni correction for ROI analyses), we found no significant group differences in FA. Subtle reductions were observed in the anterior corona radiata, forceps minor, cingulum bundle, and corpus callosum only when a lenient statistical was applied (FWE corrected p<.20). These findings suggest that alterations in the white matter microstructure of first-degree relatives, as potential vulnerability markers for OCD, are likely subtle.

DOI： 10.1016/j.pscychresns.2024.111884

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PubMed

記述言語：英語   出版者・発行元：Frontiers in Psychiatry  

Background: Hoarding disorder (HD) is characterized by cognitive control impairments and abnormal brain activity in the insula and anterior cingulate cortex (ACC) during disposal of personal items or certain executive function tasks. However, whether there are any changes in resting-state functional connectivity of the insula and ACC remains unclear. Methods: A total of 55 subjects, including 24 patients with HD and 31 healthy controls (HCs), participated in the study. We acquired resting-state functional magnetic resonance imaging data and examined group differences in functional connectivity from the insula and ACC in whole-brain voxels. Results: In patients with HD, functional connectivity was significantly lower between the right insula and right inferior frontal gyrus (IFG) and left superior temporal gyrus (STG) compared to HCs. There was no correlation between these connectivities and HD symptoms. Conclusions: Although the clinical implication is uncertain, our results suggest that patients with HD have resting-state functional alterations between the insula and IFG and STG, corresponding with the results of previous fMRI studies. These findings provide new insight into the neurobiological basis of HD.

DOI： 10.3389/fpsyt.2024.1399062

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PubMed

記述言語：英語   出版者・発行元：Psychiatry Research Neuroimaging  

Recent evidence suggests that broad brain regions, not limited to the fronto-striato-thalamo-cortical circuit, play an important role in motor response inhibition. However, it is still unclear which specific key brain region is responsible for impaired motor response inhibition observed in obsessive-compulsive disorder (OCD). We calculated the fractional amplitude of low-frequency fluctuations (fALFF) and measured response inhibition ability using the stop-signal task in 41 medication-free patients with OCD and 49 healthy control (HC) participants. We explored the brain region that shows different association between the fALFF and the ability of motor response inhibition. Significant differences in fALFF associated with the ability of motor response inhibition were identified in dorsal posterior cingulate cortex (PCC). There was a positive correlation between increased fALFF in the dorsal PCC and impaired motor response inhibition in OCD. In the HC group, there was a negative correlation between the two variables. Our results suggest that the magnitude of resting-state blood oxygen level-dependent oscillation of the dorsal PCC is a key brain region for the underlying mechanisms of impaired motor response inhibition in OCD. Future studies should examine whether this characteristic of dorsal PCC affects other large-scale networks responsible for motor response inhibition of OCD.

DOI： 10.1016/j.pscychresns.2023.111669

Scopus

PubMed

記述言語：日本語   出版者・発行元：(公財)メンタルヘルス岡本記念財団  

2019年4月から2022年3月に九州大学病院精神科神経科を受診した、ためこみ症(Hoarding disorder:HD)患者で、研究に参加協力が可能な患者にHD発症前のライフイベントについて調査した。対象者を募り、同意を得た上で詳細な生育環境・生活環境について面接による調査を行った。さらにSocial Readjustment Rating Scale(SRRS)を用いて、ためこみ症発症前に認めたライフイベントを網羅的に調査した。対象となった患者は21名(男性6名、女性15名、平均年齢45.6±11.1歳、発症平均年齢19.9±8.38歳)、併存症はADHD 13名、気分障害12名(大うつ病性障害11名、双極性1型障害1名)などであった。発症前のライフイベントに関する調査では、分離に合致するライフイベントを認めた割合は21名中18名であった。発症前のネガティブなライフイベントとしての「児童青年期のライフイベント」と所有物への信念としての「感傷的な価値」間にのみ有意な関連が認められた。

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語  

記述言語：日本語   出版者・発行元：(公財)メンタルヘルス岡本記念財団  

記述言語：日本語   出版者・発行元：(公財)メンタルヘルス岡本記念財団  

記述言語：日本語   出版者・発行元：日本認知療法・認知行動療法学会  

記述言語：日本語   出版者・発行元：(株)メディカルレビュー社  

ためこみ症は疾患としての認知度が低く,多くの患者は医療化していない。ためこみとは「所有物の実際の価値と関係なく廃棄が困難で,散らかりが持続する状態」を指し,所有物の価値への信念と自分自身への信念が相互に影響することでためこみが維持される。ためこみ症の病態を理解し,知識として一般化することは予防や治療介入にもつながり,重要である。(著者抄録)

記述言語：日本語   出版者・発行元：(株)星和書店  

ためこみ症はためこみを主症状として,所有物の価値とは関係なく廃棄が困難となり,過剰な収集や整理不能による散らかりが持続する状態を指す。ためこみ症は有用性・感傷的価値・審美的価値といった《所有物への信念》が介在した肯定的な感情反応によって廃棄が負の弱化,収集が正の強化を受け,自尊心・責任感・記憶に関する《自己への信念》が介在した否定的な感情によって廃棄が正の弱化,収集が負の強化を受けることで,ためこみが強固に維持される。《所有物への信念》はこだわり,《自己への信念》はとらわれに繋がっており,ためこみ症は「もの」へのとらわれとこだわりの両側面が影響することが特徴的である。ためこみ症はいまだ認知度が低く,多くの患者は疾患だと認識しておらず,周囲からも否定的な評価を受けている。ためこみ症への病態理解を深めることは治療関係の構築にも繋がり,その後の治療を後押しする。(著者抄録)