Updated on 2026/05/19

Information

 

写真a

 
OKA KAORI
 
Organization
Faculty of Medical Sciences Department of Stem Cell Biology and Medicine Assistant Professor
Title
Assistant Professor
External link

Research Areas

  • Life Science / Animal life science

Degree

  • 博士（生命科学） （ 2015.3 Hokkaido University ）

Research History

  • Kyushu University 大学院医学研究院 長寿幹細胞医学分野 Assistant Professor 

    2025.10 - Present

  • Kumamoto University Faculty of Life Sciences Department of Aging and Longevity Research Assistant Professor 

    2023.4 - 2025.9

  • Kumamoto University 大学院生命科学研究部 老化・健康長寿学講座 Specially Appointed Assistant Professor 

    2022.4 - 2023.3

  • Kumamoto University 大学院生命科学研究部 老化・健康長寿学講座 日本学術振興会特別研究員 

    2019.4 - 2022.3

Education

  • Hokkaido University   大学院生命科学院  

    2012.4 - 2015.3

  • Hokkaido University   大学院生命科学院  

    2010.4 - 2012.3

  • Hokkaido University   理学部   生物科学科

    2006.4 - 2010.3

Research Interests・Research Keywords

  • Research theme： Analysis of anti-aging and anti-disease mechanisms using healthy aging species

    Keyword： ハダカデバネズミ、長寿動物、がん耐性、老化耐性

    Research period： 2015.4 - Present

Awards

  • 令和6年度 熊本大学女性研究者奨励賞

    2025.3   熊本大学  

  • SfE Journal Awards 2022

    2022.11   Society for Endocrinology   Diversification of mineralocorticoid receptor genes in a subterranean rodent, the naked mole-rat

    Kaori Oka, Hidemasa Bono, Asato Kuroiwa, Shusuke Fujioka, Atsushi Shimizu, Yoshinao Katsu, Kyoko Miura

Papers

  • Establishment of primary and immortalized fibroblasts reveals resistance to cytotoxic agents and loss of necroptosis-inducing ability in long-lived Damaraland mole-rats Reviewed

    Yusuke Suzuki, Kanta Yamaguchi, Kaitlyn N. Lewis Hardell, Kurumi Ota, Taira Kamikado, Yoshimi Kawamura, Rochelle Buffenstein, Kaori Oka, Kyoko Miura

    GeroScience   47 ( 1 )   1381 - 1396   2025.2   （ ISSN:2509-2715 eISSN:2509-2723 ）

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    Authorship：Corresponding author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Springer Science and Business Media LLC  

    Abstract

    The Damaraland mole-rat (DMR; Fukomys damarensis) is a long-lived (~ 20 years) Bathyergid rodent that diverged 26 million years ago from its close relative, the naked mole-rat (NMR). While the properties of NMR cultured fibroblasts have been extensively studied and have revealed several unusual features of this cancer-resistant, long-lived species, comparative DMR studies are extremely limited. We optimized conditions for successfully culturing primary DMR skin fibroblasts and also established immortalized DMR cells using simian virus 40 early region expression. Like NMRs, DMR fibroblasts are more resistant than mice to various cytotoxins including heavy metals, DNA-damaging agents, oxidative stressors, and proteasome inhibitors. DMR genome sequencing analyses revealed the presence of premature stop codons in the master regulator genes of necroptosis, an inflammatory programmed cell death—receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL), although these mutations have different locations to those found in the NMR. DMR cells, like NMR cells, did not show significantly increased cell death in response to necroptosis induction. Our data suggest that both Bathyergid species require species-specific cell culture conditions for optimized growth, display similar resistance to cytotoxins, and show loss-of-function mutations abrogating the ability to employ necroptosis. These shared traits may contribute to their evolved adaptations to their subterranean lifestyle and prolonged longevity. These convergent insights and valuable resource may be pertinent to biomedical research.

    DOI： 10.1007/s11357-024-01420-9

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    Other Link： https://link.springer.com/article/10.1007/s11357-024-01420-9/fulltext.html

  • The Naked Mole-Rat as a Model for Healthy Aging Invited Reviewed

    Kaori Oka, Masanori Yamakawa, Yoshimi Kawamura, Nobuyuki Kutsukake, Kyoko Miura

    Annual Review of Animal Biosciences   11 ( 1 )   207 - 226   2023   （ ISSN:2165-8102 eISSN:2165-8110 ）

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Annual Reviews  

    Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and resistance to age-related functional decline/diseases. Specifically, they do not display increased mortality with age, maintain several physiological functions until nearly the end of their lifetime, and rarely develop cancer and Alzheimer's disease. NMRs live in a hypoxic environment in underground colonies in East Africa and are highly tolerant of hypoxia. These unique characteristics of NMRs have attracted considerable interest from zoological and biomedical researchers. This review summarizes previous studies of the ecology, hypoxia tolerance, longevity/delayed aging, and cancer resistance of NMRs and discusses possible mechanisms contributing to their healthy aging. In addition, we discuss current issues and future perspectives to fully elucidate the mechanisms underlying delayed aging and resistance to age-related diseases in NMRs.

    Expected final online publication date for the Annual Review of Animal Biosciences, Volume 11 is February 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

    DOI： 10.1146/annurev-animal-050322-074744

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  • Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats. Reviewed International journal

    Kaori Oka, Shusuke Fujioka, Yoshimi Kawamura, Yoshihiro Komohara, Takeshi Chujo, Koki Sekiguchi, Yuki Yamamura, Yuki Oiwa, Natsuko Omamiuda-Ishikawa, Shohei Komaki, Yoichi Sutoh, Satoko Sakurai, Kazuhito Tomizawa, Hidemasa Bono, Atsushi Shimizu, Kimi Araki, Takuya Yamamoto, Yasuhiro Yamada, Hiroyuki Oshiumi, Kyoko Miura

    Communications biology   5 ( 1 )   287 - 287   2022.3   （ eISSN:2399-3642 ）

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Communications Biology  

    Naked mole-rats (NMRs) have a very low spontaneous carcinogenesis rate, which has prompted studies on the responsible mechanisms to provide clues for human cancer prevention. However, it remains unknown whether and how NMR tissues respond to experimental carcinogenesis induction. Here, we show that NMRs exhibit extraordinary resistance against potent chemical carcinogenesis induction through a dampened inflammatory response. Although carcinogenic insults damaged skin cells of both NMRs and mice, NMR skin showed markedly lower immune cell infiltration. NMRs harbour loss-of-function mutations in RIPK3 and MLKL genes, which are essential for necroptosis, a type of necrotic cell death that activates strong inflammation. In mice, disruption of Ripk3 reduced immune cell infiltration and delayed carcinogenesis. Therefore, necroptosis deficiency may serve as a cancer resistance mechanism via attenuating the inflammatory response in NMRs. Our study sheds light on the importance of a dampened inflammatory response as a non-cell-autonomous cancer resistance mechanism in NMRs.

    DOI： 10.1038/s42003-022-03241-y

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  • Genome assembly and annotation of the naked mole rat Heterocephalus glaber reared in Japan. Reviewed International journal

    Kouhei Toga, Kaori Oka, Hiroyuki Tanaka, Takehiko Itoh, Atsushi Toyoda, Hidemasa Bono, Kyoko Miura

    Scientific data   13 ( 1 )   2026.3   （ eISSN:2052-4463 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Scientific Data  

    The naked mole rat (NMR, Heterocephalus glaber) is a eusocial rodent that is native to northeastern Africa. NMRs exhibit extraordinary traits such as longevity, resistance to age-related decline, and remarkable hypoxia tolerance. Although the reference genome of this species has been determined because of its unique characteristics, the significance or role of intraspecific genomic variations remains unknown. In this study, we used PacBio long-read sequencing to generate a genome assembly of NMR reared in Japan. The assembled genome is 2.56 Gb. Benchmarking Universal Single-Copy Orthologs (BUSCO) revealed high completeness (95.2%). BRAKER3 estimated 26,714 protein-coding genes, and we successfully added functional annotations for 26,232 protein-coding genes using the functional annotation workflow. We identified 417 gene models that were previously undetectable in the reference genome of this species. We also identified structural and amino acid sequence variations between our assembly and the reference genome, suggesting the presence of intraspecific genomic variations. This new genomic resource could help uncover the molecular mechanisms underlying the behavioral and physiological traits of NMR.

    DOI： 10.1038/s41597-026-06996-9

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  • Diversity and stability of the gut microbiome of naked mole-rat (Heterocephalus glaber), the longest-lived rodent

    Amir Rakhimov, Noriko Yasuda-Yoshihara, Masanori Arita, Kazuhiro Okumura, Yoshimi Kawamura, Kaori Oka, Hiroshi Mori, Yuichi Wakabayashi, Yoshifumi Baba, Hideo Baba, Kyoko Miura

    2026.2

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  • Spontaneous histiocytic sarcoma with peritoneal dissemination in a Damaraland mole-rat ( <i>Fukomys damarensis</i> ): The first spontaneous tumor in this species Reviewed

    Yusuke Sakai, Koki Sekiguchi, Yusuke Suzuki, Mika Kobe, Kaori Oka, Masanori Yamakawa, Yoshimi Kawamura, Rochelle Buffenstein, Kyoko Miura

    Veterinary Pathology   62 ( 6 )   1069 - 1073   2025.11   （ ISSN:0300-9858 eISSN:1544-2217 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：SAGE Publications  

    An 11-year-old, Damaraland mole-rat queen died after several months of abdominal distension with no other clinical signs, and a necropsy was performed. Grossly, numerous red-white, smooth masses, ranging from a few millimeters to 1 cm in diameter, were widely scattered across the surfaces of the diaphragm, mesentery, and peritoneum. The pulmonary hilar, mediastinal, mesenteric, and renal lymph nodes were enlarged. Histologically, the masses and the enlarged lymph nodes consisted of atypical cells with abundant eosinophilic cytoplasm and large, eccentrically positioned nuclei. Multinucleated giant cells were often intermixed with these cells. Based on the positive immunolabeling of macrophage markers IBA1 and CD163, the lack of detectable pathogens, and the prominent dissemination of these cells, these lesions were diagnosed as histiocytic sarcoma. This is the first case of histiocytic sarcoma and the first case of a spontaneous tumor in a Damaraland mole-rat, a burgeoning non-traditional animal model of longevity and purported cancer resistance.

    DOI： 10.1177/03009858251349124

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    Other Link： https://journals.sagepub.com/doi/full-xml/10.1177/03009858251349124

  • Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats. Reviewed International journal

    Yoshimi Kawamura, Kaori Oka, Takashi Semba, Mayuko Takamori, Yuki Sugiura, Riyo Yamasaki, Yusuke Suzuki, Takeshi Chujo, Mari Nagase, Yuki Oiwa, Shusuke Fujioka, Sayuri Homma, Yuki Yamamura, Shingo Miyawaki, Minoru Narita, Takaichi Fukuda, Yusuke Sakai, Takatsugu Ishimoto, Kazuhito Tomizawa, Makoto Suematsu, Takuya Yamamoto, Hidemasa Bono, Hideyuki Okano, Kyoko Miura

    The EMBO journal   42 ( 16 )   e111133   2023.8   （ ISSN:0261-4189 eISSN:1460-2075 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：EMBO Journal  

    Naked mole-rats (NMRs) have exceptional longevity and are resistant to age-related physiological decline and diseases. Given the role of cellular senescence in aging, we postulated that NMRs possess unidentified species-specific mechanisms to prevent senescent cell accumulation. Here, we show that upon induction of cellular senescence, NMR fibroblasts underwent delayed and progressive cell death that required activation of the INK4a-retinoblastoma protein (RB) pathway (termed "INK4a-RB cell death"), a phenomenon not observed in mouse fibroblasts. Naked mole-rat fibroblasts uniquely accumulated serotonin and were inherently vulnerable to hydrogen peroxide (H2 O2 ). After activation of the INK4a-RB pathway, NMR fibroblasts increased monoamine oxidase levels, leading to serotonin oxidization and H2 O2 production, which resulted in increased intracellular oxidative damage and cell death activation. In the NMR lung, induction of cellular senescence caused delayed, progressive cell death mediated by monoamine oxidase activation, thereby preventing senescent cell accumulation, consistent with in vitro results. The present findings indicate that INK4a-RB cell death likely functions as a natural senolytic mechanism in NMRs, providing an evolutionary rationale for senescent cell removal as a strategy to resist aging.

    DOI： 10.15252/embj.2022111133

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  • Carcinogenesis resistance in the longest-lived rodent, the naked mole-rat. Reviewed International journal

    Yuki Yamamura, Yoshimi Kawamura, Kaori Oka, Kyoko Miura

    Cancer science   113 ( 12 )   4030 - 4036   2022.12   （ ISSN:1347-9032 eISSN:1349-7006 ）

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    Language：English   Publishing type：Research paper (scientific journal)   Publisher：Cancer Science  

    Certain mammalian species are resistant to cancer, and a better understanding of how this cancer resistance arises could provide valuable insights for basic cancer research. Recent technological innovations in molecular biology have allowed the study of cancer-resistant mammals, despite the fact that they are not the classical model animals, which are easily studied using genetic approaches. Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodent, with a maximum lifespan of more than 37 years, and almost never show spontaneous carcinogenesis. NMRs are currently attracting much attention from aging and cancer researchers, and published studies on NMR have continued to increase over the past decade. Cancer development occurs via multiple steps and involves many biological processes. Recent research on the NMR as a model for cancer resistance suggests that they possess various unique carcinogenesis-resistance mechanisms, including efficient DNA repair pathways, cell-autonomous resistance to transformation, and dampened inflammatory response. Here, we summarize the molecular mechanisms of carcinogenesis-resistance in NMR, which have been uncovered over the past two decades, and discuss future perspectives.

    DOI： 10.1111/cas.15570

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Presentations

  • 日本で飼育するハダカデバネズミのゲノム解読

    栂浩平, 岡香織, 坊農秀雅, 三浦恭子

    第48回 日本分子生物学会年会  2025 

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    Event date： 2025.12

  • ハダカデバネズミの健康長寿メカニズムの探求 Invited

    岡香織

    第11回北大部局横断シンポジウム  2025.10 

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    Event date： 2025.10

    Presentation type：Symposium, workshop panel (nominated)  

  • 最長寿齧歯類ハダカデバネズミにおける 加齢性疾患耐性メカニズムの探求 Invited

    岡香織, 三浦恭子

    第45回 阿蘇シンポジウム  2025.8 

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    Event date： 2025.8

    Presentation type：Symposium, workshop panel (nominated)  

  • Different mechanisms for in vivo cancer resistance in long-lived rodents, naked mole-rats and Damaraland mole-rats

    Kaori Oka

    THE 53rd NAITO CONFERENCE ON Germ Cell Biology: Uncovering Mysteries of Continuity and Discontinuity  2025.7 

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    Event date： 2025.7

    Presentation type：Poster presentation  

  • 健康長寿モデル動物ハダカデバネズミにおける人工授精法の確立と出産率の向上

    奥村果林, 鈴木悠介, 岡香織, 河村佳見, 三浦恭子

    第72回 日本実験動物学会総会  2025 

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    Event date： 2025.5

  • 長寿齧歯類ハダカデバネズミ・ダマラランドデバネズミにおける 発がん耐性機構の解析

    岡 香織

    JSIR次世代リーダー育成スクール 2025  2025.5 

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    Event date： 2025.5

    Presentation type：Oral presentation (general)  

  • がん化耐性動物ハダカデバネズミにおけるがん遺伝子HRASV12導入による脳腫瘍形成

    中村一輝, 河村佳見, 大西伸幸, 藤原章雄, 菰原義弘, 佐谷秀行, 岡香織, 三浦恭子

    第48回 日本分子生物学会年会  2025.12 

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    Event date： 2025

  • 長寿齧歯類ダマラランドデバネズミから樹立した皮膚線維芽細胞はハダカデバネズミ細胞と類似した細胞死耐性を持つ

    鈴木悠介, 山口侃太, Kaitlyn N. Lewis Hardell, 太田胡桃, 上門平, 河村佳見, Rochelle Buffenstein, 岡香織, 三浦恭子

    第48回 日本分子生物学会年会  2025.12 

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    Event date： 2025

  • 長寿動物ダマラランドデバネズミにおける加齢性変化の解析

    太田胡桃, 坂井祐介, 関口功記, 鈴木裕介, 大貫永輝, 神田美幸, 奥原啓輔, 坊農秀雅, 岡香織, 三浦恭子

    第48回 日本分子生物学会年会  2025.12 

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    Event date： 2025

  • 老化耐性齧歯類ハダカデバネズミにおける皮膚色変化を規定する要因と白色化メカニズムの解析

    中本万貴, 山崎理予, 河村佳見, 岡香織, 三浦恭子

    第48回 日本分子生物学会年会  2025.12 

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    Event date： 2025

  • ダマラランドデバネズミにおける化学発がん誘導耐性の検討

    関口功記, 岡香織, 長瀬茉莉, 佐野優衣, 中本万貴, 太田胡桃, 河辺美加, 尾上奈穂, 井上奈南, 三川翔夢, 坂井祐介, 櫻井智子, 藤原章雄, 河村佳見, 山本拓也, Rochelle Buffenstein, 菰原義弘, 三浦恭子

    第48回 日本分子生物学会年会  2025.12 

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    Event date： 2025

  • Unique regulation of cell death in the naked mole-rat, a long-lived cancer-resistant rodent Invited

    Kaori Oka

    BIOMORA24 Unique biology of mole-rats from husbandry to biomedical applications  2024.11 

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    Event date： 2024.11

    Presentation type：Oral presentation (invited, special)  

  • ハダカデバネズミ特異的に高発現している遺 伝子 のスクリーニングによる長寿化遺伝子の探索

    太田 胡桃, 関口 功記, 鈴木 悠介, 岡 香織, 河村 佳見, 中條 岳志, 中村 輝, 小幡 史明, 山本 拓也, 三浦恭子

    日本動物学会第95回長崎大会  2024.9 

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    Event date： 2024.9

    Presentation type：Oral presentation (general)  

  • 長寿齧歯類ダマラランドデバネズミ皮膚線維芽細胞の樹立と細胞死応答の解析

    鈴木 悠介, 山口 侃太, 上門 平, 関口 功記, 河村 佳見, 岡 香織, 三浦 恭子

    日本動物学会第95回長崎大会  2024.9 

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    Event date： 2024.9

    Presentation type：Oral presentation (general)  

  • 長寿・がん耐性齧歯類における細胞死制御とがん耐性との連関 Invited

    岡香織

    2023年度 先端モデル動物支援プラットフォーム 成果発表会  2024.2 

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    Event date： 2024.2

    Presentation type：Symposium, workshop panel (nominated)  

  • Unique regulation of cell death in long‐lived cancer‐resistant rodents Invited

    岡香織

    日本進化学会第25回沖縄大会  2023.9 

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    Event date： 2023.8 - 2023.9

    Presentation type：Symposium, workshop panel (nominated)  

  • Establishment of skin fibroblasts and analysis of cell death response in Damaraland mole-rats

    鈴木悠介, 山口侃太, 上門平, 河村佳見, 岡香織, 三浦恭子

    第45回 日本分子生物学会年会  2022.12 

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    Event date： 2022

  • 老化・がん化耐性齧歯類ハダカデバネズミ〜不思議な動物をモデル動物に〜 Invited

    岡香織

    第47回日本比較内分泌学会大会及びシンポジウム 九州大会  2023.11 

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    Presentation type：Oral presentation (invited, special)  

  • 老化の解明～動物モデルが拓く健康長寿への挑戦～　老化耐性齧歯類ハダカデバネズミにおけるINK4a-RB経路を介した細胞死誘導機構

    河村 佳見, 岡 香織, 三浦 恭子

    日本獣医学会学術集会講演要旨集  2024.8  (公社)日本獣医学会

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    Language：Japanese  

  • 最長寿齧歯類ハダカデバネズミの新規モデル動物としての可能性

    河村 佳見, 岡 香織, 三浦 恭子

    日本内分泌学会雑誌  2025.5  (一社)日本内分泌学会

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    Language：Japanese  

  • 最長寿齧歯類ハダカデバネズミにおける抗加齢・抗疾患メカニズム Invited

    岡香織, 河村佳見, 三浦恭子

    第25回 日本抗加齢医学会総会  2025.6 

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    Presentation type：Oral presentation (invited, special)  

  • 人工授精法の確立はハダカデバネズミにおける出産率を改善する(Establishment of an artificial insemination method improves the birth rate in the naked mole-rat)

    Okumura Karin, Suzuki Yusuke, Oka Kaori, Kawamura Yoshimi, Miura Kyoko

    Experimental Animals  2025  (公社)日本実験動物学会

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    Language：English  

  • Analysis of the mechanisms of cancer resistance in two species of African mole-rats, naked mole-rat and Damaraland mole-rat

    岡香織, 関口功記, 三浦恭子

    第46回日本分子生物学会年会  2023.12 

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    Presentation type：Symposium, workshop panel (nominated)  

  • エイジングの種多様性～寿命はどうやって決まるのか?～　最長寿齧歯類ハダカデバネズミにおける抗加齢・抗疾患メカニズム

    岡 香織, 河村 佳見, 三浦 恭子

    日本抗加齢医学会総会プログラム・抄録集  2025.5  (一社)日本抗加齢医学会

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    Language：Japanese  

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MISC

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Professional Memberships

  • 分子生物学会

  • 炎症再生医学会

Other

  • 【河合塾 みらいぶっく】がんになりにくい！ ハダカデバネズミは健康ご長寿さん

    2025.10

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    https://miraibook.jp/researcher/k25644

  • 北大部局横断シンポジウム 特別ワークショップ

    2025.10

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    https://www.youtube.com/watch?v=NGuV48QNWXk

Research Projects

  • 最長寿・がん化耐性齧歯類ハダカデバネズミにおいて過度の炎症を防ぐメカニズムの解明

    2026.3

    公益財団法人小林財団  研究助成 

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    Authorship：Principal investigator 

  • 健康長寿モデル動物ハダカデバネズミにおける肺線維症耐性メカニズムの解明

    2025.12

    公益財団法人内藤記念科学振興財団  女性研究者研究助成金 

  • 健康長寿モデル動物ハダカデバネズミにおける皮膚色制御メカニズムの解明

    2025.11

    公益財団法人コーセーコスメトロジー研究財団  コスメトロジー研究助成 

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    Authorship：Principal investigator 

  • 健康長寿齧歯類ハダカデバネズミに高発現する塩基修飾酵素による長寿化メカニズム

    Grant number：25K09477  2025.4 - 2028.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Scientific Research (C)

    岡 香織

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    Grant type：Scientific research funding

    ハダカデバネズミは最大寿命40年の最長寿齧歯類で、老化関連疾患の発症がほぼみられないため、健康長寿モデル動物として注目されている。我々は、ハダカデバネズミ特異的に高発現する遺伝子のスクリーニングから、長寿化遺伝子として2種類の塩基修飾酵素を同定した。本研究では、これらの遺伝子がどのようなメカニズムで長寿化に寄与しているかを明らかにし、新たな核酸修飾による寿命・老化制御の分子機構を提示することで、将来的な新規の健康長寿法開発につなげることを目指す。

    CiNii Research

  • がん耐性哺乳類に共通するミスセンス変異遺伝子の役割の解明

    Grant number：22K15024  2022.4 - 2025.3

    Grants-in-Aid for Scientific Research  Grant-in-Aid for Early-Career Scientists

    岡 香織

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    Grant type：Scientific research funding

    がんはヒトや家庭動物には頻発するが、ハダカデバネズミやアフリカゾウなど一部の動物種においては非常に稀である。なぜ種によって、がんの発生頻度は異なるのだろうか。本研究では、申請者が見出した「がん耐性哺乳類に共通したミスセンス変異」に着目し、このアミノ酸変異がどのような機能を有するか、また、がん防御と関連しているのかを明らかにする。これにより、がん耐性動物種共通の耐性メカニズムを解明し、将来的にがんの革新的予防法・治療法開発につなげることを目指す。

    CiNii Research

  • 老化・がん化耐性齧歯類ハダカデバネズミにおける特異な免疫システムの解明

    Grant number：19J00641 

    岡 香織

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    Grant type：Scientific research funding

    免疫システムの適切な制御は生体内外の異物に応答し恒常性を維持するために重要であり、免疫機能の量的・質的な変化は老化や疾患と密接に結びついている。申請者は最近、老化・がん化に対して著しい耐性をもつ最長寿齧歯類であるハダカデバネズミで、免疫システムが特殊化している可能性を見出した。本研究では、ハダカデバネズミと他種の免疫応答の違いを規定するメカニズムを明らかにし、疾患耐性・長寿化を実現する生体防御機構の本態を解明することを目指す。

    CiNii Research

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Teaching Student Awards

  • MBSJ Poster Award

    Year and month of award：2025.12

    Classification of award-winning students：Doctoral student   Name of award-winning student：鈴木悠介

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    指導学生が学会ポスター賞を受賞した