Updated on 2026/06/29

Information

 

写真a

 
SOMA MIKA
 
Organization
Faculty of Medical Sciences Department of Basic Medicine Assistant Professor
School of Medicine Department of Medicine（Concurrent）
Title
Assistant Professor
External link

Research Areas

  • Life Science / Psychiatry

Degree

  • 博士 (学術) （ 2017.3 The University of Tokyo ）

Research History

  •  Faculty of Medical Sciences Department of Basic Medicine  Assistant Professor 

    2025.11 - Present

  • Kyushu University 大学院医学研究院 生体制御学講座 神経解剖学分野 Academic Researcher 

    2025.10

  • Nippon Medical School 大学院 医学研究科 解剖学・神経生物学分野 Academic Researcher 

    2023.4 - 2025.9

  • Nihon University 文理学部 生命科学科 Research Assistant 

    2021.4 - 2023.3

  • Nihon University 文理学部 自然科学研究所 Academic Researcher 

    2020.4 - 2021.3

  • Teikyo University 薬学部 認知神経科学講座 Research Assistant 

    2017.6 - 2020.3

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Education

  • The University of Tokyo   総合文化研究科 広域科学専攻 博士課程   生命環境科学系

    2014.4 - 2017.3

  • The University of Tokyo   総合文化研究科 広域科学専攻 修士課程   生命環境科学系

    2012.4 - 2014.3

  • The University of Tokyo   薬学部   薬科学科

    2008.4 - 2012.3

  • Hitotsubashi University   経済学部  

    2004.4

Research Interests・Research Keywords

  • Research theme： Pathogenesis of male climacteric disorder

    Keyword： 男性更年期障害, 海馬, シナプス

    Research period： 2025.10 - Present

  • Research theme： Effects of estrogen on schizophrenia

    Keyword： 統合失調症, エストロゲン, 海馬, シナプス

    Research period： 2025.10 - Present

Papers

  • Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity Invited Reviewed

    Suguru Kawato, Yasushi Hojo, Mika Soma, Shigeo Horie, Minoru Saito and Mari Ogiue-Ikeda

    Frontiers in Cellular Neuroscience   19   2026.1

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fncel.2025.1695565.

  • Optimized selection of specific antibodies against rodent ESR1 proteins and their application for immunohistochemistry and dual immunohistofluorescence with the specific anti-ESR2 antibody PPZ0506. Reviewed International journal

    Mika Soma, Masahiro Morishita, Shimpei Higo, Kenta Sekiya, Hirotaka Ishii

    Histochemistry and cell biology   164 ( 1 )   4 - 4   2026.1   （ ISSN:0948-6143 eISSN:1432-119X ）

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)   Publisher：Histochemistry and Cell Biology  

    The development of immunohistochemical and immunohistofluorescence assays is essential for investigating the tissue and cellular distribution of target proteins. In this study, we identify specific anti-ESR1 antibodies against rodent ESR1 proteins and evaluate their applicability for immunohistochemistry and dual immunohistofluorescence with the specific anti-ESR2 antibody PPZ0506. We assessed the specificity and cross-reactivity of six commercially available anti-ESR1 antibodies (Clones MC-20, C1355, E115, H4624, SP1, and F-10) against mouse and rat ESR1 proteins using immunoblotting and immunocytofluorescence assays. Among them, MC-20, C1355, E115, and H4624 exhibited specific immunoreactivity to mouse and rat ESR1 proteins. These four antibodies were subsequently applied to paraffin-embedded ovarian and uterine sections from mice and rats. Heat-induced antigen retrieval and an appropriate antibody dilution were required to obtain specific and adequate signals. MC-20 and E115 were suitable for immunohistochemical detection of ESR1 proteins, while C1355 was effective for uterine tissue staining. H4624 showed utility only in mouse tissues. Furthermore, rabbit-derived MC-20 and E115 antibodies were successfully employed in dual immunohistofluorescence assays with the mouse monoclonal PPZ0506 antibody, enabling simultaneous visualization of ESR1 and ESR2 proteins in paraffin-embedded ovarian sections. Notably, little cellular co-localization of ESR1 and ESR2 proteins was observed in mouse and rat ovarian sections. These findings provide a validated set of antibodies for ESR1 immunohistochemical detection and demonstrate their compatibility with ESR2 co-labeling, facilitating detailed analysis of estrogen receptor distribution in rodent tissues.

    DOI： 10.1007/s00418-025-02454-6

    Web of Science

    Scopus

    PubMed

  • Perinatal Exposure of Bisphenol A Differently Affects Dendritic Spines of Male and Female Grown-Up Adult Hippocampal Neurons Reviewed

    Suguru Kawato, Mari Ogiue-Ikeda, Mika Soma, Hinako Yoshino, Toshihiro Kominami, Minoru Saito, Shuji Aou and Yasushi Hojo

    Frontiers in Neuroscience   15 ( 712261 )   2021.9

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fnins.2021.712261.

  • Ingested d-Aspartate Facilitates the Functional Connectivity and Modifies Dendritic Spine Morphology in Rat Hippocampus Reviewed

    Akihiko Kitamura, Yasushi Hojo, Muneki Ikeda, Sachise Karakawa, Tomomi Kuwahara, Jonghyuk Kim, Mika Soma, Suguru Kawato and Tomokazu Tsurugizawa

    Cerebral Cortex   29 ( 6 )   2499 - 2508   2019.6

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/cercor/bhy120.

  • Src Kinase Dependent Rapid Non-genomic Modulation of Hippocampal Spinogenesis Induced by Androgen and Estrogen Reviewed

    Mika Soma, Jonghyuk Kim, Asami Kato and Suguru Kawato

    Frontiers in Neuroscience   12 ( 282 )   2018.5

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fnins.2018.00282.

  • Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid Reviewed

    Murakami G, Hojo Y, Kato A, Komatsuzaki Y, Horie S, Soma M, Kim J, Kawato S.

    Journal of Neuroendocrinology   30 ( 2 )   2018.2

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    Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/jne.12561.

  • Dysbindin-1, a schizophrenia-related protein, interacts with HDAC3 Reviewed

    Mika Soma, Min Wang, Satoshi Suo, Shoichi Ishiura

    Neuroscience Letters   582   120 - 124   2014.10

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    Authorship：Lead author   Language：English   Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.neulet.2014.08.046.

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Presentations

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MISC

Professional Memberships

  • 日本解剖学会

    2024.9 - Present

  • 日本抗加齢医学会

    2018.1 - Present

  • 日本神経科学学会

    2017.6 - Present

Research Projects

  • 脳海馬が合成する男性・女性ホルモンによる神経シナプスの急性的制御機構

    Grant number：23K14304  2023.4 - 2026.3

    日本学術振興会  科学研究費助成事業  若手研究

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    Authorship：Principal investigator 

Class subject

  • 肉眼解剖学

    2025.9 - Present   Second semester

  • 神経解剖学

    2025.9 - Present   Second semester

FD Participation

  • 2026.4   Role：Participation   Title：令和８年度　第１回全学FD（新任教員FDの研修）

    Organizer：University-wide