2026/08/26 更新

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写真a

ハギハラ　ヨウタ
萩原 遥太
HAGIHARA YOTA
所属
医学研究院 基礎医学部門 助教
医学部 医学科（併任）
職名
助教

論文

  • Subcellularly Resolved 3D Translatome in Mouse Oocytes and Early Embryos.

    Ren J, Furniss S, Zhou C, Zhou H, Hagihara Y, Wang X, Zhang Y

    bioRxiv : the preprint server for biology   2026年8月

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    記述言語：英語  

    DOI： 10.64898/2026.07.31.742119

    PubMed

  • Precise modulation of BRG1 levels reveals features of mSWI/SNF dosage sensitivity 査読 国際誌

    Hagihara Y., Zhang C., Zhang Y.

    Nature Genetics   57 ( 9 )   2250 - 2263   2025年9月   （ ISSN:10614036 ）

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Nature Genetics  

    Mammalian switch/sucrose nonfermentable (mSWI/SNF) complex regulates chromatin accessibility and frequently shows alterations due to mutation in cancer and neurological diseases. Inadequate expression of mSWI/SNF in heterozygous mice can lead to developmental defects, indicating dosage-sensitive effects of mSWI/SNF. However, how its dosage affects function has remained unclear. Using a targeted protein degradation system, we investigated its dosage-sensitive effects by precisely controlling protein levels of BRG1, the ATPase subunit of the mSWI/SNF complex. We found that binding of BRG1 to chromatin exhibited a linear response to the BRG1 protein level. Although chromatin accessibility at most promoters and insulators was largely unaffected by BRG1 depletion, 44% of enhancers, including 84% of defined superenhancers, showed reduced accessibility. Notably, half of the BRG1-regulated enhancers, particularly superenhancers, exhibited a buffered response to BRG1 loss. Consistently, transcription exhibited a predominantly buffered response to changes in BRG1 levels. Collectively, our findings demonstrate a genomic feature-specific response to BRG1 dosage, shedding light on the dosage-sensitive effects of mSWI/SNF complex defects in cancer and other diseases.

    DOI： 10.1038/s41588-025-02305-z

    Scopus

  • Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells 査読 国際誌

    Yota Hagihara and Satoshi Asada and Takahiro Maeda and Toru Nakano and Shinpei Yamaguchi

    PLOS Genetics   17 ( 6 )   e1009646   2021年6月

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Public Library of Science ({PLoS})  

    DOI： 10.1371/journal.pgen.1009646

  • Primordial germ cell‐specific expression of eGFP in transgenic chickens 査読 国際誌

    Yota Hagihara and Yuya Okuzaki and Kazuma Matsubayashi and Hidenori Kaneoka and Takayuki Suzuki and Shinji Iijima and Ken-ichi Nishijima

    genesis   58 ( 8 )   2020年8月   （ ISSN:1526-954X ）

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    担当区分：筆頭著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

    DOI： 10.1002/dvg.23388

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