Kyushu University Academic Staff Educational and Research Activities Database
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Takeshi Uchiumi Last modified date:2022.06.21

Professor / Department of Health Sciences,
Department of Health Sciences
Faculty of Medical Sciences

Graduate School
Undergraduate School

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 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Medical Doctor 
Country of degree conferring institution (Overseas)
Field of Specialization
Biochemistry, Molecular Biology、Clinical chemistry、Clinical Chemistry and Laboratory Medicine
Total Priod of education and research career in the foreign country
Research Interests
  • Physiological function analysis of mitochondrial protein ABCB10
    keyword : mitochondria transporter
  • New molecular mechnism of the functional interaction between mitochondria and lysosome
    keyword : mitochondria, lysosome, NAD, functional interaction
  • New approch for measurement of clinical chemistry

    keyword : Clinical chemistry
  • Mitochondria and cancer
    keyword : mitochondria
  • Functional analysis of mitochondrial protein p32
    keyword : p32 , mitochondria , translation
  • Cross talk between cytoplasm and mitochndria translation
    keyword : mitochondria translation
  • Mitochondria related gene and Cancer
    keyword : Mitochondria , tumor, translation, replication, siRNA
  • Multifunction of YB-1 gene response to stress- cross-talk to translation, transcription and repair
    keyword : YB-1, translation, transcription, repair
Academic Activities
1. Yagi, M., Toshima, T., Amamoto, R., Do, Y., Hirai, H., Setoyama, D., Kang, D. & Uchiumi, T.,, Mitochondrial translation deficiency impairs NAD+-mediated lysosomal acidification, EMBO Journal, 40, 8, e105268., 2021.04.
2. 内海 健, Mutation and functional analysis of ABCC2/multidrug resistance protein 2 in a Japanese patient with Dubin-Johnson syndrome., Hepatol. Research, 43, 569-575, 2013.02.
3. Fukuda, T., Ashizuka, M., Nakamura, T., Shibahara,K., Maeda, K., Izumi, I., Kohno, K., Kuwano, M.,and Uchiumi,T.,, Characterization of 5'untranslated region of YB-1 mRNA and plausible regulation of translation., Nucleic Acid Res, 2004.01.
4. Kuwano, M., Uchiumi, T., Hayakawa, H., Ono, M., Wada, M., Izumi, H., and Kohno, K, The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies., Cancer Sci, 10.1111/j.1349-7006.2003.tb01344.x, 94, 1, 9-14, 94: 9-14, 2003.01.
5. Kohno K, Izumi H, Uchiumi T, Ashizuka M, and Kuwano M, The pleiotropic functions of the Y-box-binding protein, YB-1, Bioessays, 10.1002/bies.10300, 25, 7, 691-698, 25: 691-698, 2003.01.
6. Ashizuka, M., Fukuda, T., Nakamura, T., Shirasuna, K., Iwai, K., Izumi, H., Kohno, K., Kuwano, M., and Uchiumi, T., Novel translational control through an iron-responsive element by interaction of multifunctional protein YB-1 and IRP2., Mol Cell Biol, 10.1128/MCB.22.18.6375-6383.2002, 22, 18, 6375-6383, 22: 6375-6383, 2002.01.
7. Hashimoto K.,Uchiumi T., Konno T., Ebihara T., Nakamura T., Wada M., Sakisaka S., Maniwa F., Amachi T., Ueda K., and Kuwano M., Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome., Hepatology, 10.1053/jhep.2002.36368, 36, 5, 1236-1245, 36:1236-1245, 2002.01.
8. Haga, S., Hinoshita, E., Ikezaki, K., Fukui, M., Scheffer, G. L., Uchiumi, T. and Kuwano, M., Involvement of the multidrug resistance protein 3 in drug sensitivity and its expression in human glioma., Jpn. J. Cancer Res, 92, 2, 211-219, 92: 211-219, 2001.01.
9. Hinoshita, E., Taguchi, K., Inokuchi, A., Uchiumi, T., Kinukawa, N., Shimada, M., Tsuneyoshi, M., Sugimachi, K. and Kuwano, M., Decreased expression of an ATP-binding cassette transporter, MRP2, in human livers with hepatitis C virus infection., J. Hepatology, 10.1016/S0168-8278(01)00216-1, 35, 6, 765-773, 35,765-773, 2001.01.
10. Inokuchi, A., Hinoshita, E., Wada, M., Iwamoto, Y., Kohno, K., Kuwano, M. and Uchiumi, T., Enhanced expression of Human Multidrug resistance protein 3 by bile salt in human enterocytes: a transcriptional control of plausible bile acid transporter., J. Biol. Chem., 10.1074/jbc.M104612200, 276, 50, 46822-46829, 276: 46822-46829, 2001.01.
11. Hinoshita, E., Uchiumi, T., Taguchi, K., Kinukawa, N., Tsuneyoshi, M., Maehara, Y., Sugimachi, K. and Kuwano, M., Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas., Clin Cancer Res, 6, 6, 2401-2407, 6:2401-2407, 2000.01.
12. Kawabe, T., Chen, Z., Wada, M., Uchiumi, T., Ono, M., Akiyama, S. and Kuwano, M., Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2)., FEBS Lett., 10.1016/S0014-5793(99)00979-5, 456, 2, 327-331, 456: 327-331, 1999.01.
13. Tanaka,T., Uchiumi,T., Hinoshita,E., Inokuchi,A., Toh,S., Wada,M., Takano,H., Kohno,K., and Kuwano,M., The human multispecific resistance protein2 gene : functional characterization of 5'-flanking region and expression in hepatic cells., Hepatology, 30: 1507-1512, 1999.01.
14. Uchiumi, T., Hinoshita, E., Haga, S., Nakamura, T., Tanaka, T., Toh, S., Furukawa, M., Kawabe, T., Wada, M., Kagotani, K., Okumura, K., Kohno, K., Akiyama, S. and Kuwano, M., Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport., Biochem. Biophys. Res. Commun, 10.1006/bbrc.1998.9546, 252, 1, 103-110, 252: 103-110, 1998.01.
15. Uchiumi, T., Longo, D. and Ferris, D, Cell cycle regulation of PLK promoter., J. Bio. Chem, 272,9166-9174, 1997.01.
1. 内海 健, KANG DONGCHON, 八木美佳子, Cardiomyocyte Specific Deletion of p32/C1qbp Causes Mitochondrial Cardiomyopathy, EuroMit, 2014.06.
2. 内海 健, p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA binding ability, ミトコンドリア学会, 2013.11.
Membership in Academic Society
  • American Association of Cancer Research
  • Japanease Cancer Association
Educational Activities
As an undergraduate education, I am in charge of lectures for 1st grade, 2nd grade and 3rd grade of health science. Clinical Chemistry I, Clinical Chemistry II, General Management,
He teaches basic research to fourth-year undergraduate students.
As for graduate school education, 3 doctoral students from the Faculty of Medicine and 4 master's graduate students are all engaged in research activities.