Papers

1.	Kiichiro Teruya, Yoshihiro Kusumoto, Hiroshi Eto, Noboru Nakamichi, Sanetaka Shirahata, Selective suppression of cell growth and programmed cell death-ligand 1 expression in HT1080 fibrosarcoma cells by low molecular weight fucoidan extract, Marine Drugs, 10.3390/md17070421, 17, 7, 17(7)421, 2019.07, Low molecular weight fucoidan extract (LMF), prepared by an abalone glycosidase digestion of a crude fucoidan extracted from Cladosiphon novae-caledoniae Kylin, exhibits various biological activities, including anticancer effect. Various cancers express programmed cell death-ligand 1 (PD-L1), which is known to play a significant role in evasion of the host immune surveillance system. PD-L1 is also expressed in many types of normal cells for self-protection. Previous research has revealed that selective inhibition of PD-L1 expressed in cancer cells is critical for successful cancer eradication. In the present study, we analyzed whether LMF could regulate PD-L1 expression in HT1080 fibrosarcoma cells. Our results demonstrated that LMF suppressed PD-L1/PD-L2 expression and the growth of HT1080 cancer cells and had no effect on the growth of normal TIG-1 cells. Thus, LMF differentially regulates PD-L1 expression in normal and cancer cells and could serve as an alternative complementary agent for treatment of cancers with high PD-L1 expression..
2.	Kiichiro Teruya, Yuki Myojin-Maekawa, Fumio Shimamoto, Hiromitsu Watanabe, Noboru Nakamichi, Koichiro Tokumaru, Sennosuke Tokumaru, Sanetaka Shirahata, Protective effects of the fermented milk Kefir on X-ray irradiation-induced intestinal damage in B6C3F1 mice., Biological and Pharmaceutical Bulletin, 10.1248/bpb.b12-00709, 36, 3, 352-359, 2013.03.
3.	Zhongyuan Zhang, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata, Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1271/bbb.120631, 77, 2, 235-242, 2013.02.
4.	Zhongyuan Zhang, Kiichiro Teruya, Toshihiro Yoshida, Hiroshi Eto, Sanetaka Shirahata, Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells, Marine Drugs, 10.3390/md11010081, 9, 11, 81-98, 2013.01.
5.	Zhongyuan Zhang, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata, Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ros-dependent JNK activation and mitochondria-mediated pathways., PLoS One., 6, 11, e27441, 2011.11.
6.	Kiichiro Teruya, Yoshihito Daimon, Xiao-Yan Dong, Yoshinori Katakura, Takumi Miura, Akira Ichikawa, Tsukasa Fujiki, Makiko Yamashita, Tetsuya Mori, Hideya Ohashi, Sanetaka Shirahata, An Approach to Further Enhance the Cellular Productivity of Exogenous Protein Hyper-producing Chinese Hamster Ovary (CHO) Cells, Cytotechnology, 10.1007/s10616-005-3765-4, 47, 1-3, 29-36, 47, 29-36, 2005.01.
7.	Ryuhei Nishikawa, Kiichiro Teruya, Yoshinori Katakura, Kazuhiro Osada, Takeki Hamasaki, Taichi Kashiwagi, Takaaki Komatsu, Yuping Li, Jun& Ye, Akira Ichikawa, Kazumichi Otsubo, Shinkatsu Morisawa, Qianghua Xu, Sanetaka Shirahata, Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation, Cytotechnology, 10.1007/s10616-005-3759-2, 47, 1-3, 97-105, 47, 97-105, 2005.01.
8.	Jun Ye, Yuping Li, Kiichiro Teruya, Yoshinori Katakura, Akira Ichikawa, Hiroshi Eto, Mutsutaka Hosoi, Masako Hosoi, Shinji Nishimoto, Sanetaka Shirahata, Enzyme-digested Fucoidan Extracts Derived from Seaweed Mozuku of Cladosiphon novae-caledoniaekylin Inhibit Invasion and Angiogenesis of Tumor Cells, Cytotechnology, 10.1007/s10616-005-3761-8, 47, 1-3, 117-126, 47, 117-126, 2005.01.

Presentations

1.	Yoshihiro Kusumoto, Shingo Kajisa, Hiroshi Eto, Toshihiro Yoshida, Sanetaka Shirahata, Kiichiro Teruya, Combined Use of Enzymatically Digested Low-Molecular Weight Fucoidan Extract and Anti-Cancer Drugs Enhances Their Anti-Cancer Effects., The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology, 2016.11.
2.	Yuko Ishibashi, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata, Enzymatically digested low-molecular weight fucoidan suppresses the growth of cancer cells., The 27th Annual and International Meeting of the Japanese Association for Animal Cell Technology, 2014.11.
3.	Ririko Goto, Kiichiro Teruya, Hiroshi Eto, Toshihiro Yoshida, Sanetaka Shirahata, Combined use of enzymatically digested low-molecular weight fucoidan extract and an anti-cancer drug enhance their anti-tumor effects., The 27th Annual and International Meeting of the Japanese Association for Animal Cell Technology, 2014.11.
4.	Kiichiro Teruya, Sanetaka Shirahata, Cancer Cell-Specific Apoptosis Induction and Alteration of Cell Surface Sugar Chain Structures by Low Molecular Weight Fucoidan Extract. , The 27th Annual and International Meeting of the Japanese Association for Animal Cell Technology, 2014.11.
5.	Kiichiro Teruya, Takeki Hamasaki, Zhongyuan Zhang, Hiroshi Eto, Sanetaka Shirahata, Cancer Cell-specific Apoptosis Induction and Alteration of Cell Surface Sugar Chain Structures by Low Molecular Weight Fucoidan Extract., IUFoST 2014, 17th World Congress of Food Science and Technology, 2014.08.

[Graduate School]
Seminar of Cellular Regulation Technology (1997-2010)
Advanced in Systems Biological Chemistry (2010-)
Project research in Systems Biology (2010-)
Advanced in Cellular Function Technology (2016-)
Basic Cellular Regulation Technology (2016)

[Undergraduate School ]
Basic Biology (2008-2014)
Molecular Cell Biology (2015-)
Laboratory Course of Analytical Chemistry (2009-2017)
Laboratory Work of Basic Microbiology (2012-)
Laboratory Work of Food Chemistry (2012-2017)
Laboratory Work of Physical Chemistry (2018-)
Physical Chemistry (2014-)
G30 Food Science (2015-)

[Common University's education]
Core Seminar (2008)
Natural Science Experiments　(2015-2016, 2018, ２０２０)