| 照屋 輝一郎（てるや きいちろう） | データ更新日：2024.01.26 |
助教 ／
農学研究院
生命機能科学部門
システム生物工学
| 1. | Takeki Hamasakia, Taichi Kashiwagi, Takaaki Komatsua, Shigeru Kabayama, Noboru Nakamichi, Kiichiro Teruya, Sanetaka Shirahata, A new colorimetric method for determining antioxidant levels using 3,5-dibromo-4- nitrosobenzene sulfonate (DBNBS)., MethodsX, 10.1016/j.mex.2022.101797, 9, 2022.07. |
| 2. | Mizuki Ogawa, Miyako Udono, Kiichiro Teruya, Norihisa Uehara, Yoshinori Katakura, Exosomes Derived from Fisetin-Treated Keratinocytes Mediate Hair Growth Promotion, Nutrients, 10.3390/nu13062087, 13, 6, 2021.06, Enhanced telomerase reverse transcriptase (TERT) levels in dermal keratinocytes can serve as a novel target for hair growth promotion. Previously, we identified fisetin using a system for screening food components that can activate the TERT promoter in HaCaT cells (keratinocytes). In the present study, we aimed to clarify the molecular basis of fisetin-induced hair growth promotion in mice. To this end, the dorsal skin of mice was treated with fisetin, and hair growth was evaluated 12 days after treatment. Histochemical analyses of fisetin-treated skin samples and HaCaT cells were performed to observe the effects of fisetin. The results showed that fisetin activated HaCaT cells by regulating the expression of various genes related to epidermogenesis, cell proliferation, hair follicle regulation, and hair cycle regulation. In addition, fisetin induced the secretion of exosomes from HaCaT cells, which activated β-catenin and mitochondria in hair follicle stem cells (HFSCs) and induced their proliferation. Moreover, these results revealed the existence of exosomes as the molecular basis of keratinocyte-HFSC interaction and showed that fisetin, along with its effects on keratinocytes, caused exosome secretion, thereby activating HFSCs. This is the first study to show that keratinocyte-derived exosomes can activate HFSCs and consequently induce hair growth.. |
| 3. | Kiichiro Teruya, Yoshihiro Kusumoto, Hiroshi Eto, Noboru Nakamichi, Sanetaka Shirahata, Selective suppression of cell growth and programmed cell death-ligand 1 expression in HT1080 fibrosarcoma cells by low molecular weight fucoidan extract, Marine Drugs, 10.3390/md17070421, 17, 7, 17(7)421, 2019.07, [URL], Low molecular weight fucoidan extract (LMF), prepared by an abalone glycosidase digestion of a crude fucoidan extracted from Cladosiphon novae-caledoniae Kylin, exhibits various biological activities, including anticancer effect. Various cancers express programmed cell death-ligand 1 (PD-L1), which is known to play a significant role in evasion of the host immune surveillance system. PD-L1 is also expressed in many types of normal cells for self-protection. Previous research has revealed that selective inhibition of PD-L1 expressed in cancer cells is critical for successful cancer eradication. In the present study, we analyzed whether LMF could regulate PD-L1 expression in HT1080 fibrosarcoma cells. Our results demonstrated that LMF suppressed PD-L1/PD-L2 expression and the growth of HT1080 cancer cells and had no effect on the growth of normal TIG-1 cells. Thus, LMF differentially regulates PD-L1 expression in normal and cancer cells and could serve as an alternative complementary agent for treatment of cancers with high PD-L1 expression.. |
| 4. | Hidenori Takahashi, Mitsuhiko Kawaguchi, Kunihiro Kitamura, Seiji Narumiya, Munenori Kawamura, Isamu Tengan, Shinji Nishimoto, Yasuo Hanamure, Yasuo Majima, Shuichi Tsubura, Kiichiro Teruya, Sanetaka Shirahata, An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients, Integrative Cancer Therapies, 10.1177/1534735417692097, 17, 2, 282-291, 2018.06. |
| 5. | Takeki Hamasaki, Gakuro Harada, Noboru Nakamichi, Shirgeru Kabayama, Kiichiro Teruya, Bunshi Fugetsu, Wei Gong, Ichiro Sakata, Sanetaka Shirahata, Electrochemically reduced water exerts superior reactive oxygen species scavenging activity in HT1080 cells than the equivalent level of hydrogen-dissolved water, PLOS ONE, 10.1371/journal.pone.0171192, 12, 2, 2017.02. |
| 6. | Taichi Kashiwagi, Hanxu Yan, Takeki Hamasaki, Tomoya Kinjo, Noboru Nakamichi, Kiichiro Teruya, Shigeru Kabayama, Sanetaka Shirahata, Electrochemically reduced water protects neural cells from oxidative damage., Oxidative Medicine and Cellular Longevity, 10.1155/2014/869121, 2014, 2014.10. |
| 7. | Takeki Hamasaki, Noboru Nakamichi, Kiichiro Teruya, Sanetaka Shirahata, Removal Efficiency of Radioactive Cesium and Iodine Ions by a Flow-Type Apparatus Designed for Electrochemically Reduced Water Production., PLOS ONE, 10.1371/journal.pone.0102218, 9, 7, 2014.07. |
| 8. | Kosuke Tomimatsu, Shin-ei Matsumoto, Hayato Tanaka, Makiko Yamashita, Hidekazu Nakanishi, Kiichiro Teruya, Saiko Kazuno, Tomoya Kinjo, Takeki Hamasaki, Ken-ichi Kusumoto, Shigeru Kabayama, Yoshinori Katakura, Sanetaka Shirahata, A rapid screening and production method using a novel mammalian cell display to isolate human monoclonal antibodies., Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2013.10.007, 2013.10. |
| 9. | Hidekazu Nakanishi, Takeki Hamasaki, Kiichiro Teruya, Noboru Nakamichi, Sanetaka Shirahata, Tomoya Kinjo, Hanxu Yan, Shigeru Kabayama, Low concentration platinum nanoparticles effectively scavenge reactive oxygen species in rat skeletal L6 cells., Nano Biomedicine And Engineering, 10.5101/nbe.v5i2.p76-85., 5, 2, 76-85, 2013.06. |
| 10. | Kiichiro Teruya, Yuki Myojin-Maekawa, Fumio Shimamoto, Hiromitsu Watanabe, Noboru Nakamichi, Koichiro Tokumaru, Sennosuke Tokumaru, Sanetaka Shirahata, Protective effects of the fermented milk Kefir on X-ray irradiation-induced intestinal damage in B6C3F1 mice., Biological and Pharmaceutical Bulletin, 10.1248/bpb.b12-00709, 36, 3, 352-359, 2013.03. |
| 11. | Zhongyuan Zhang, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata, Induction of Apoptosis by Low-Molecular-Weight Fucoidan through Calcium- and Caspase-Dependent Mitochondrial Pathways in MDA-MB-231 Breast Cancer Cells, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 10.1271/bbb.120631, 77, 2, 235-242, 2013.02. |
| 12. | Zhongyuan Zhang, Kiichiro Teruya, Toshihiro Yoshida, Hiroshi Eto, Sanetaka Shirahata, Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells, Marine Drugs, 10.3390/md11010081, 9, 11, 81-98, 2013.01. |
| 13. | Tomoya Kinjo, Jun Ye, Hanxu Yan, Takeki Hamasaki, Hidekazu Nakanishi, Kazuko Toh, Noboru Nakamichi, Shigeru Kabayama, Kiichiro Teruya, Sanetaka Shirahata, Suppressive effects of electrochemically reduced water on matrix metalloproteinase-2 activities and in vitro invasion of human fibrosarcoma HT1080 cells, CYTOTECHNOLOGY, 10.1007/s10616-012-9469-7, 64, 3, 357-371, 2012.05. |
| 14. | Sanetaka Shirahata, Takeki Hamasaki, Kiichiro Teruya, Advanced research on the health benefit of reduced water., Trends in Food Science and Technology, 23, 124-131, 2012.02. |
| 15. | Yupin Li, Takeki Hamasaki, Kiichiro Teruya, Noboru Nakamichi, Zbigniew Gadek, Taichi Kashiwagi, Hanxu Yan, Tomoya Kinjo, Takaaki Komatsu, Yoshitoki Ishii, Sanetaka Shirahata, Suppressive effects of natural reduced waters on alloxan-induced apoptosis and type 1 diabetes mellitus., Cytotechnology, 10.1007/s10616-011-9414-1, 64, 281-297, 2011.12. |
| 16. | Zhongyuan Zhang, Kiichiro Teruya, Hiroshi Eto, Sanetaka Shirahata, Fucoidan extract induces apoptosis in MCF-7 cells via a mechanism involving the ros-dependent JNK activation and mitochondria-mediated pathways., PLoS One., 6, 11, e27441, 2011.11. |
| 17. | Hanxu Yan, Tomoya Kinjo, Huaize Tian, Takeki Hamasaki, Kiichiro Teruya, Shigeru Kabayama, Sanetaka Shirahata, Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water-participation of pt nanoparticles., Biosci. Biotech. Biochem., 75, 1295-1299, 2011.07. |
| 18. | Keishi Kadooka, Asuka Imahayashi, Ayaka Koiso, Makiko Yamashita, Kiichiro Teruya, Takashi Matsumoto, Takanori Hasegawa, Fumiki Morimatsu, Yoshinori Katakura, Establishment of a novel method of screening anti-Allergic lactic acid bacteria., Biosci. Biotech. Biochem., 75, 1016-1018, 2011.05. |
| 19. | Yupin Li, Takeki Hamasaki, Noboru Nakamichi, Taichi Kashiwagi,, Takaaki Komatsu, Jun Ye, Kiichiro Teruya, Masumi Abe, Hanxu Yan, Tomoya Kinjo, Shigeru Kabayama, Munenori Kawamura, Sanetaka Shirahata, Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus, Cytotechnology, 63, 2, 119-131, 2011.04. |
| 20. | Yan, H., Tian, H., Kinjo, T., Hamasaki, T., Tomimatsu, K., Nakamichi, N., Teruya, K., Kabayama, S., Shirahata, S. , Extension of the lifespan of Caenorhabditis elegans by the use of electrolyzed reduced water., Biosci. Biotechnol. Biochem., 74, 10, 2011-2015, 2010.10. |
| 21. | Fujiki, T., Tsuji, A., Matsumoto, S.E., Yamashita, M., Teruya, K., Shirahata, S., Katakura, Y. , Generation of a human anti-tumor necrosis factor-α monoclonal antibody by in vitro immunization with a multiple antigen peptide., Biosci. Biotechnol. Biochem., 74, 9, 1836-1840 , 2010.09. |
| 22. | Tomimatsu, K., Matsumoto, S., Yamashita, M., Teruya, K., Katakura, Y., Kabayama, Shirahata, S. , Production of human monoclonal antibodies against FcεRIα by a method combining in vitro immunization with phage display, Biosci. Biotechnol. Biochem., 73, 7, 1465-1469, 2009.07. |
| 23. | Matsumoto, S., Yamashita, M., Katakura, Y., Aiba, Y., Tomimatsu, K., Kabayama, S., Teruya, K., Shirahata, S. , A rapid and efficient strategy to generate antigen-specific human monoclonal antibody by in vitro immunization and the phage display method, J. Immunol. Methods., 31, 19-26, 2008.03. |
| 24. | Jung, Y.-S., Matsumoto, S., Katakura, Y., Yamashita, M., Tomimatsu, K., Kabayama, S., Teruya, K., Shirahata, S. , Generation of human monoclonal antibodies against Propionibacterium acnes by applying the phage display method to human peripheral blood mononuclear cells immunized in vitro, Cytotechnology, in press, 2008.02. |
| 25. | Ye, J., Li, Y., Hamasaki, T., Nakamichi, N., Komatsu, T., Kashiwagi, T., Teruya, K., Nishikawa, R., Kawahara, T., Osada, K., Toh, K., Abe, M., Tian, H., Kabayama, S., Otsubo, K., Morisawa, S., Katakura, Y., Shirahata, S. , Inhibitory effect of electrolyzed reduced water on tumor angiogenesis, Biol. Pharm. Bull., 31, 19-26, 2008.01. |
| 26. | Tamura, T., Tomimatsu, K., Katakura, Y., Yamashita, M., Matsumoto, S. E., Aiba, Y., Jung, Y. S., Abe, Y., Fujiki, T., Teruya, K., Shirahata, S. , Anti-peptide antibody production elicited by in vitro immunization of human peripheral blood mononuclear cells, Biosci. Biotechnol. Biochem., 71, 2871-2875, 2007.12. |
| 27. | Ye, J., Li, Y., Hamasaki, T., Nakamichi, N., Kawahara, T., Osada, K., Teruya, K., Kato, Y., Toh, K., Abe, M., Katakura, Y., Noguchi, K., Shirahata, S. , Catalyser-21, a mineral water derived from leaf soil, inhibits tumor cell invasion and angiogenesis, Cytotechnology, 55, 61-70, 2007.12. |
| 28. | Yamashita, M., Katakura, Y., Aiba, Y., Matsumoto, S. E., Morihara, K., Teruya, K., Ichikawa, A., Shirahata, S. , Involvement of IL-10 in the suppression of antibody production by in vitro immunized peripheral blood mononuclear cells, Cytotechnology, 55, 71-77, 2007.12. |
| 29. | Jung, Y.-S., Matsumoto, S., Yamashita, M., Tomimatsu, K., Teruya, K., Katakura, Y., Shirahata, S. , Propionibacterium acnes acts as an adjuvant in in vitro immunization of human peripheral blood mononuclear cells, Biosci. Biotechnol. Biochem., 71, 1963-1969, 2007.08. |
| 30. | Shin-ei Matsumoto, Makiko Yamashita, Yoshinori Katakura, Eri Noguchi, Yoshihiro Aiba, Akira Ichikawa, Kiichiro Teruya, Sanetaka Shirahata, In vitro immunization can elicit the expansion of diverse repertoire of B cells from peripheral blood mononuclear cells, Cytotechnology, 52, 227-233 , 2006.11. |
| 31. | Yoshihiro Aiba, Makiko Yamashita, Yoshinori Katakura, Yuki Furukawa, Shin-Ei Matsumoto, Kousuke Tomimatsu, Kiichiro Teruya, Sanetaka Shirahata, Identification of Genes Involved in the Suppression of Antibody Production from Human Peripheral Blood Lymphocytes, Biosci. Biotechnol. Biochem., 70, 966-970, 2006.04. |
| 32. | Yuko Kato, Masaya Ohta, Kyouhei Kamei, Hisanobu Wakita, Takeshi Kawahara, Yuuichiro Yamano, Takeki Hamasaki, Kiichiro Teruya, Kazuhiro Osada, Ryuhei Nishikawa, Katsumi Noguchi, Sanetaka Shirahata, Structure Analysis of Complex Carbohydrate Exhibiting IL-12 Inducing Activity Derived from Mineral Water in Natural Leaf Soil, BUNSEKI KAGAKU, 10.2116/bunsekikagaku.54.391, 54, 5, 391-397, 54, 391-397, 2005.05. |
| 33. | Kiichiro Teruya, Yoshihito Daimon, Xiao-Yan Dong, Yoshinori Katakura, Takumi Miura, Akira Ichikawa, Tsukasa Fujiki, Makiko Yamashita, Tetsuya Mori, Hideya Ohashi, Sanetaka Shirahata, An Approach to Further Enhance the Cellular Productivity of Exogenous Protein Hyper-producing Chinese Hamster Ovary (CHO) Cells, Cytotechnology, 10.1007/s10616-005-3765-4, 47, 1-3, 29-36, 47, 29-36, 2005.01. |
| 34. | Ryuhei Nishikawa, Kiichiro Teruya, Yoshinori Katakura, Kazuhiro Osada, Takeki Hamasaki, Taichi Kashiwagi, Takaaki Komatsu, Yuping Li, Jun& Ye, Akira Ichikawa, Kazumichi Otsubo, Shinkatsu Morisawa, Qianghua Xu, Sanetaka Shirahata, Electrolyzed Reduced Water Supplemented with Platinum Nanoparticles Suppresses Promotion of Two-stage Cell Transformation, Cytotechnology, 10.1007/s10616-005-3759-2, 47, 1-3, 97-105, 47, 97-105, 2005.01. |
| 35. | Jun Ye, Yuping Li, Kiichiro Teruya, Yoshinori Katakura, Akira Ichikawa, Hiroshi Eto, Mutsutaka Hosoi, Masako Hosoi, Shinji Nishimoto, Sanetaka Shirahata, Enzyme-digested Fucoidan Extracts Derived from Seaweed Mozuku of Cladosiphon novae-caledoniaekylin Inhibit Invasion and Angiogenesis of Tumor Cells, Cytotechnology, 10.1007/s10616-005-3761-8, 47, 1-3, 117-126, 47, 117-126, 2005.01. |
本データベースの内容を無断転載することを禁止します。