Kyushu University Academic Staff Educational and Research Activities Database
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Chikako Kiyohara Last modified date:2022.05.16

Lecturer / Department of Environmental Health and Socio-Medical Sciences
Center for Cohort Studies
Faculty of Medical Sciences

Graduate School
Undergraduate School
Other Organization

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Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
Outline of research
1) Molecular epidemiology of lung diseases
2) Study on atopic desease and bacterial community in the gastrointestinal tract
3) Molecular epidemiology on systemic lupus erythematosus
4) Molecular epidemiology of attention deficit hyperactivity disorder in school children

Outline of education
Faculty of medicine; Public Health , Core Seminar
Master Course of Medical Biochmistry; Medicine, Medical treatment and Community IV
Docter Course of Medical Sciences; Epidemiologic Reseach

Committee of Building Council
Research Interests
  • Genome epidemiology of chronic respiratory diseases
    keyword : Idiopathic Pulmonary Fibrosis
  • Genome epidemioly of lung cancer
    keyword : polymorphism, drug-metabolism, DNA excision repair, inflammation
    1994.04Genome epidemioly of lung cancer.
  • Epidemiology of systemic lupus erythematosus
    keyword : genetic polymorphisms TNF drug-metabolizing enzyme
    2004.04Epidemiology of SLE.
  • Molecular epidemiology of atopic disease
    keyword : atopic dermatitis genetic polymorphism, gene-environment interaction
    2007.04~2010.03Molecular epidemiology of atopic disease.
  • Epidemiology of attention deficit hyperactivity disorder
    keyword : maternal smoking, dopamine-related genes
    2004.04~2018.03Epidemiology of ADHD.
  • Epidemiology of Parkinson's disease
    keyword : smoking, genetic polymorphism
    2007.04~2016.03Epidemiology of ADHD.
Current and Past Project
  • The primary goals of the project are:

    To study the association between genetic polymorphisms and cancer
    To investigate the association and interaction between polymorphisms
    To determine geographic and ethnic prevalence of the polymorphisms
    To create a data base for future studies on metabolic genes and molecular epidemiology of cancer
    To facilitate collaboration between scientists from different countries
  • The International Lung Cancer Consortium (ILCCO) is an international group of lung cancer researchers, established in 2004 with the aim of sharing comparable data from ongoing lung cancer case-control and cohort studies. Questionnaire data from a total of 26000 case-control pairs, and the biological samples from the majority of the subjects would be available. These studies are from different geographical areas and ethnicities. The overall objectives are to achieve greater power, especially for subgroup analyses, reduce duplication of research effort, replicate novel findings, and afford substantial cost savings through large collaborative efforts.

    Working groups were formed to oversee research areas that were considered a priority for the consortium, including: (i) Genetic susceptibility, (ii) Young onset and family history, (iii) Never smokers, (iv) Rare histology, (v) somatic mutation, (vi) Statistics and the others. Please see Working Groups for the complete list of current working groups.
Academic Activities
1. Kiyohara C, Ohno Y., Sex differences in lung cancer susceptibility: a review. , Gend Med., 7(5):381-401., 2010.10.
2. Kiyohara C*, Yoshimasu K, Takayama K, Nakanishi Y, Lung cancer susceptibility: are we on our way to identifying a high-risk group? , Future Oncol, 3: 617-627, 2007.12.
1. Kawasaki S, Kiyohara C, Karashima Y, Yamaura K., Blood pressure management after reperfusion in living-donor kidney transplantation., Transplant Proc., 10.1016, 52, 10, 3009-3016, 2020.12.
2. Kiyohara C, Takayama K, Nakanishi Y. , Lung cancer risk and genetic polymorphisms in DNA repair pathways: a meta-analysis., J Nucleic Acids, 2010, 701760, 2010.10.
3. Kiyohara C, Horiuchi T, Miyake Y, Takayama K, Nakanishi Y., Cigarette smoking, TP53 Arg72Pro, TP53BP1 Asp353Glu and the risk of lung cancer in a Japanese population., Oncol Rep., 23, 5, 1361-1368, 2010.05.
4. Truong T, Sauter W, McKay JD, Hosgood HD 3rd, Gallagher C, Amos CI, Spitz M, Muscat J, Lazarus P, Illig T, Wichmann HE, Bickeböller H, Risch A, Dienemann H, Zhang ZF, Naeim BP, Yang P, Zienolddiny S, Haugen A, Le Marchand L, Hong YC, Kim JH, Duell EJ, Andrew AS, Kiyohara C, Shen H, Matsuo K, Suzuki T, Seow A, Ng DP, Lan Q, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Constantinescu V, Bencko V, Foretova L, Janout V, Caporaso NE, Albanes D, Thun M, Landi MT, Trubicka J, Lener M, Lubinski J; EPIC-lung, Wang Y, Chabrier A, Boffetta P, Brennan P, Hung RJ., International Lung Cancer Consortium: coordinated association study of 10 potential lung cancer susceptibility variants., Carcinogenesis, 31, 4, 625-633, 2010.04.
5. Kiyohara C, Yoshimasu K., Association between major depressive disorder and a functional polymorphism of the 5-hydroxytryptamine (serotonin) transporter gene: a meta-analysis., Psychiatr Genet., 20, 2, 49-58, 2010.04.
6. Kiyohara C, Horiuchi T, Takayama K, Nakanishi Y., IL1B rs1143634 polymorphism, cigarette smoking, alcohol use, and lung cancer risk in a Japanese population., J Thorac Oncol., 5, 3, 299-304, 2010.03.
7. Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H; Kyushu Sapporo SLE (KYSS) Study Group., Cigarette smoking, STAT4 and TNFRSF1B polymorphisms, and systemic lupus erythematosus in a Japanese population.
, J Rheumatol. , 36, 10, 2095-2203, 2009.10.
8. Kiyohara C, Washio M, Horiuchi T, Tada Y, Asami T, Ide S , Takahashi H, Kobashi G and the Kyushu Sapporo SLE (KYSS) Study Group., Cigarette smoking, N-acetyltransferase 2 polymorphism and systemic lupus erythematosus in a Japanese population. , Lupus, 18(7):630-638., 2009.06.
9. Matsusue A, Kiyohara C,Tanaka K, Sasaki S, Miyake Y, ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children., Clin Biochem, 42(6): 477-483., 2009.04.
10. Hung RJ, Christiani DC, Risch A, Popanda O, Haugen A, Zienolddiny S, Benhamou S, Bouchardy C, Lan Q, Spitz MR, Wichmann HE, LeMarchand L, Vineis P, Matullo G, Kiyohara C, Zhang ZF, Pezeshki B, Harris C, Mechanic L, Seow A, Ng DP, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Caporaso N, Chen C, Duell EJ, Goodman G, Field JK, Houlston RS, Hong YC, Landi MT, Lazarus P, Muscat J, McLaughlin J, Schwartz AG, Shen H, Stucker I, Tajima K, Matsuo K, Thun M, Yang P, Wiencke J, Andrew AS, Monnier S, Boffetta P, Brennan P., International lung cancer consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways., Cancer Epidemiol Biomarkers Prev. , 17(11):3081-9., 2008.11.
11. Ozawa M, Washio M, Kiyohara C., Factors related to starting and continuing smoking among senior high school boys in Fukuoka, Japan., Asian Pac J Cancer Prev. , 9(2):239-45.
, 2008.05.
12. Lee KM, Kang D, Clapper ML, Ingelman-Sundberg M, Ono-Kihara M, Kiyohara C, Min S, Lan Q, Le Marchand L, Lin P, Lung ML, Pinarbasi H, Pisani P, Srivatanakul P, Seow A, Sugimura H, Tokudome S, Yokota J, Taioli E., CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations., Cancer Epidemiol Biomarkers Prev. , 17(5):1120-6., 2008.05.
13. Kiyohara C, Wakai K, Mikami H, Sido K, Ando M, Ohno Y, Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women., Int J Cancer, 10.1002/ijc.11355, 107, 1, 139-144, 107: 139-144, 2003.01.
Educational Activities
Faculty of Medicine; Public Health (the fourth and the sixth years)
Faculty of Medicine; Core Seminar (the first years)
Master Course of Medical Biochmistry; Medicine, Medical statistics (16/16)
Medical statistics (16/16)
Other Educational Activities
  • 2011.08.
  • 2010.04.
  • 2009.04.