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Atsushi Takaki Last modified date：2022.11.01

Assistant Professor / Science for Biological Information, Integrative Physiology
Department of Basic Medicine
Faculty of Medical Sciences


Graduate School
Department of Physiological Sciences
Graduate School of Medical Sciences


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/atsushi-takaki
　Reseacher Profiling Tool　Kyushu University Pure
http://www.med.kyushu-u.ac.jp/physiol/main_J.html
Dept. Integrative Physiology, Graduate School of Medical Sciences .
Phone
092-642-6089
Fax
092-642-6093
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Psychosomatic Medicine, Environmental Physiology, Alternative Medicine
Total Priod of education and research career in the foreign country
00years00months
Research
Research Interests
  • Orally administered plasmalogens alleviate negative mood states and enhance mantalconcentration
    keyword : Plasmalogens, 8-OHdG
    2018.04～2019.03.
  • Developmental study of the simplified measurement kit using new 8OHdG recognition molecules
    keyword : 8-oxo-dG, assay kit
    2015.03～2021.12.
  • A new method to isolate nucleic acids in urine and/or plasma using molecular sieve made by charcoal
    keyword : molecular sieve, charcoal, nano silica
    2016.06～2019.03.
  • Development of 8-oxo dG assay kit
    keyword : 8-oxo dG
    2010.04～2017.03.
  • Scientific inspection study on maturational degree and enzyme activity quantification of the fermentation seasoning liquid
    keyword : fermented seasoning, collagenaze, lipaze
    2015.03～2016.03.
  • An induction of "KOKU" taste such as glutathione and cysteine using fermented seasoning
    keyword : fermented seasoning, glutathione
    2010.06～2010.11.
  • ANTI-OXIDANT ACTIVITY OF YOUNG GREEN BARLEY LEAVES
    keyword : Barely leaves, anit-oxidant activity, guanosine-oxidation test
    2009.12～2010.03.
  • EVALUATION OF FUNCTIONAL FOOD USING AN INDEX OF DNA OXIDATIVE DAMAGE
    keyword : Functional food, DNA oxidative damage
    2009.11～2015.03.
  • EVALUATION OF FUCOIDAN DERIVED FROM SARGASSUM HOMEN(AKAMOKU)
    keyword : Sargassum homen, Fucoidan
    2009.10～2011.03.
  • METHOD OF REINFORCING CATALYST REACTION
    keyword : Photocatalysism, Electomagnetic induction, Semiconductor catalyst
    1999.04～2010.03.
  • The usefulness evaluation of various antioxidant therapies and new development
    keyword : antioxidant therapies
    2002.04～2015.03.
  • The role that oral nuclear protein food serves as for the reinforcement of the living body protective system
    keyword : Th1/Th2, nuclear protein
    1999.04～2003.03.
  • The oxidation, antioxidant ability (usefulness evaluation as functional foods) of cereals
    keyword : whole grain cereals, oxidation, antioxidant
    2006.04～2010.03.
  • A design and effect evaluation of the Mg reduction water
    keyword : Mg reduction water
    2005.04～2010.03.
  • Design of 8-oxo-dG recognition molecules
    keyword : 8-oxo-dG, DNA damage
    2005.04～2015.03.
  • Developmental study of the simplified measurement kit using new 8OHdG recognition molecules
    keyword : 8-oxo-dG, assay kit
    2008.04～2015.03.
  • SIMPLEFIED BIOLOGICAL EVALUATION METHOD OF NATURAL AND ARTIFICIAL CHEMICALS BY USING DNA INJURY INDEZ AND APPARATUS THEREFOR
    keyword : 8OHdG, 8oxo-deoxyguanosine, Oxidative stress marker、Mutagenicity, DNA damage
    1999.04～2015.03.
Current and Past Project
  • Scientific inspection study on maturational degree and enzyme activity quantification of the fermentation seasoning liquid
  • Commercialization of brown alga extract and it's bulk powder containing fucoidan
Academic Activities
Reports
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Papers
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1. Matsuoka T, Takaki A, Ohtaki H, Shioda S., Early changes to oxidative stress levels following exposure to formaldehyde in ICR mice, J Toxicol Sci., 35(5):721-30, 2010.05.
2. Kyota Fujita, Toshihiro Seike, Noriko Yutsudo, Mizuki Ohno, Hidetaka Yamada, Hiroo Yamaguchi, Kunihiko Sakumi, Yukiko Yamakawa, Mizuho A. Kido, Atsushi Takaki, Toshihiko Katafuchi, Yoshinori Tanaka, Yusaku Nakabeppu, Mami Noda, Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-terahydropyridine mouse model of Parkinson’s disease, PLos ONE , l4(9): e7247, 2009.09.
3. A. Takaki, Q.-H. Huang, A. Somogyv?-Vigh and A. Arimura, Immobilization stress may increases plasma interleukin (IL) -6 via central and peripheral catecholamines. ., 1994, Neuroimmunomoduration, 1: 335-342, 1994.01.
Presentations
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1. Gene Expression Pattern in Hepatocytes of Oryzias latipes in Brown Algae Extract Containing Water..
2. We investigated moisturizing effect of brown algae extract containing polysaccharides in soap. We measured amount of moisture and ratio of water evaporation in the cuticle before and after immersion of the soap. In results, an addition of brown algae extract can keep the retention of water in the cuticle at least within 10 minutes after cleansing. It may be useful for the care of dry skin. .
3. It is, recently, known that hydrogen molecule inhibits pathological mechanisms of oxidative stress diseases. The study evaluated effects of hydrogen molecules on living objects by quantifying difference in gene expressions of liver cells of medaka exposed to hydrogen gas. The results showed that exposure to hydrogen gas regulated twelve gene expressions. If these gene expressions are studied more profoundly in future studies, a new therapeutic strategy applied hydrogen gas might be addressed..
4. We investigated contents of vitamins and anti-oxidative activities in terms of extracts of young green barley leaves with or without heat treatment. Though vitamin C was decomposed by dry-heat treatment (80℃, 30min), other vitamins and bio-active materials did not decrease. In addition, total anti-oxidative potent was not diminished by wet-heat treatment（90℃, 10min）as well as by dry-heat treatment. .
5. We have investigated oxidative and/or anti-oxidative roles of KEI-GYOKU-KOU using a guanosine-oxidative test to indicate mutagenic or carcinogenic risk (PCT/JP/02085). Results showed KEI-GYOKU-KOU possesses potent anti-oxidative ability against KBrO3-induced oxidation of deoxy-guanosine. .
6. We have addressed oxidative and/or anti-oxidative roles of Coix lacryma-jobi using guanosin-oxidation test which indicates the mutagenic and the carcinogenic risk (PCT/JP01/02085). In results, hot water extract of the grain with outer shell showed a potent anti-oxidative role against KBrO3 -induced oxidation of deoxyguanosine, but that without it did not. All anti-oxidative responses induced by any part of grain were diminished by a pre-incubation in the S9 mix solution. .


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