Kyushu University Academic Staff Educational and Research Activities Database
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Satoshi O Suzuki Last modified date:2020.02.14

Associate Professor / Pathobiology
Department of Basic Medicine
Faculty of Medical Sciences

Graduate School
Undergraduate School
Other Organization

Web site of Dept. of Neuropathology. .
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
Field of Specialization
Total Priod of education and research career in the foreign country
Outline Activities
Clinicopathological service: Pathological diagnosis of inside and outside biopsy and autopsy cases.
Research activity: 1) Neuropathological diagnostics 2) Developmental neuroscience 3) Oncogenesis and migration of brain tumors 4) Pathology and biology of epilepsy
Educational activity:1) Training of postgraduate researchers 2) Courses for undergraduate students
Social activity: None
Research Interests
  • Studies on metabolic states of brain tumors
    keyword : brain tumors, glucose metabolism, lipid metabolism, immunostaining
  • Studies on pathodiagnostics of brain tumors
    keyword : brain tumors, immunostaining
  • Studies on the mechanisms of infiltrative growth in gliomas.
    keyword : glioma, slice culture, viral vector, time-lapse imaging, guidance molecule,
    2002.12~2025.03A study on migratory behavior of glioma cells in the brain: I'm attempting to analyze migratory behavior of glioma cells in the brain environment with special regard to migratory scaffolds and guidance molecules. Fluorescent-labeled glioma cells are transplanted in the brain tissue. Structures and molecules serving as migratory scaffolds, as well as attractants and repellants will be investigated. The goal of the study is to establish a therapeutic strategy for blocking glioma invasion..
  • Studies on development of the central nervous system from embryonic period through adulthood
    keyword : brain, glia, neuron, progenitor, stem cell, slice culture, viral vector, time-lapse imaging
    2002.12~2008.03A study on development of the central nervous system from embryonic through adult period: I'm attmpting to follow the dynamic cell migration during brain development at various periods and regions by viral labling of the progenitors. My goal is to elucidate the relationship between cell fates and migratory patterns..
  • Intracellular mechanisms of migration of neural progenitors
    keyword : neuron, glia, progenitor, migration, microtubules, motor protein, dynein, dynactin, dynamitin, LIS1
    2002.12~2008.03Both neuronal and glial progenitors have highly motile leading processes that probe the environment. Once a migratory direction is decided, a cell translocates its cell body along the leading process. When the function of microtubule is blocked, the cell polarity is lost and nuclear translocation is inhibited. I'm attempting to clarify the intrinsic machinery for this specific migratory behavior by looking at dynamics of microtubules and microtuble associated proteins..
  • Role of astrocytes in epileptic brains
    keyword : epilepsy, astrocyte, glutamate, glutamate transpoter, ATP, purine receptor, tripartite synapse
    2002.12~2003.12Altered regulation of synaptic function by astrocytes may have a role to epileptogenesis as well as neural circuit remodeling. The goal of the study is to shed a light on astrocytic regulation of neurotransmitters such as glutamate and ATP in model animals and human surgical specimens and contribute to therapeutics of eplepsy..
Current and Past Project
  • Study on postnatal neural development and regenerative medicine in the central nervous system
  • Differentiation, proliferation and infiltration patterns of glioma stem cells in the intracerebral environment.
  • Clinicopathological evaluation of dementia in the Hisayama study.
Academic Activities
1. Satoshi O Suzuki, Peter Canoll, Understanding of neural development with special reference to glia and its relevance to neuroregeneration. in Suzuki SO and Yonemitsu Y (eds) Recent Advances in Neurogenesis, Neuroregeneration and Neuroprotection. Research Signpost, Trivandrum , Research Signpost, Trivandrum, Kerala, India , pp.1-18, 2009.01.
1. Suzuki SO and Iwaki T. Immunohistochemical markers for histopathological diagnosis of brain tumors.
2. Suzuki SO. Migration patterns of glia and glioma cells--their origins, pathways, and destinations.
1. Yamashita K, Hatae R, Hiwatashi A, Togao O, Kikuchi K, Momosaka D, Yamashita Y, Kuga D, Hata N, Yoshimoto K, Suzuki SO, Iwaki T, Iihara K, Honda H., Predicting TERT promoter mutation using MR images in patients with wild-type IDH1 glioblastoma., Diagn Interv Imaging. , 10.1016/j.diii.2019.02.010, in press, 2019.04.
2. Hamasaki H, Honda H, Suzuki SO, Shijo M, Ohara T, Hatabe Y, Okamoto T, Ninomiya T, Iwaki T., Tauopathy in basal ganglia involvement is exacerbated in a subset of patients with Alzheimer's disease: The Hisayama study., Alzheimers Dement (Amst)., 10.1016/j.dadm.2019.04.008. eCollection 2019 Dec, 11, 415-423, 2019.06.
3. Sarukawa M, Morioka T, Murakami N, Shimogawa T, Mukae N, Kuga N, Suzuki SO, Iihara K., Human tail-like cutaneous appendage with a contiguous stalk of limited dorsal myeloschisis., Childs Nerv Syst., 10.1007/s00381-019-04071-w, 35, 6, 973-978, 2018.08.
4. Tomita Y, Morioka T, Murakami N, Noguchi Y, Sato Y, Suzuki SO., Slender Stalk with Combined Features of Saccular Limited Dorsal Myeloschisis and Congenital Dermal Sinus in a Neonate., Pediatr Neurosurgery., 10.1159/000495810, 54, 2, 125-131, 2019.01.
5. Murakami N, Morioka T, Shimogawa T, Mukae N, Inoha S, Sasaguri T, Suzuki SO, Iihara K., Ependyma-Lined Canal with Surrounding Neuroglial Tissues in Lumbosacral Lipomatous Malformations: Relationship with Retained Medullary Cord., Pediatr Neurosurgery., 10.1159/000494029, 53, 6, 387-394, 2018.11.
6. Shen C, Honda H, Suzuki SO, Maeda N, Shijo M, Hamasaki H, Sasagasako N, Fujii N, Iwaki T., Dynactin is involved in Lewy body pathology., Neuropathology., 10.1111/neup.12512, 38, 6, 583-590, 2018.09.
7. Hiraoka A, Morioka T, Murakami N, Suzuki SO, Mizoguchi M., Limited dorsal myeloschisis with no extradural stalk linking to a flat skin lesion: a case report., Childs Nerv Syst., 10.1007/s00381-018-3938-z, 34, 12, 2497-2501, 2018.08.
8. Shimogawa T, Morioka T, Murakami N, Mukae N, Hashiguchi K, Suzuki SO, Iihara K., Bony and Cartilaginous Tissues in Lumbosacral Lipomas., Pediatr Neurosurgery., 10.1159/000490391, 53, 5, 305-310, 2018.07.
9. Maeda N, Honda H, Suzuki SO, Fujii N, Kira JI, Iwaki T., Mitochondrial dysfunction and altered ribostasis in hippocampal neurons with cytoplasmic inclusions of multiple system atrophy., Neuropathology., 10.1111/neup.12482, in press, 2018.07.
10. Morioka T, Suzuki SO, Murakami N, Mukae N, Shimogawa T, Haruyama H, Kira R, Iihara K., Surgical histopathology of limited dorsal myeloschisis with flat skin lesion., Childs Nerv Syst., 10.1007/s00381-018-3870-2, 35, 1, 119-128, 2018.07.
11. Yuhei Sangatsuda, Nobuhiro Hata, Satoshi O. Suzuki, Yojiro Akagi, Ryusuke Hatae, Daisuke Kuga, Koji Yoshimoto, Seiya Momosaki, Toru Iwaki, Koji Iihara, An elderly case of malignant small cell glioma with hemorrhage coexistent with a calcified pilocytic astrocytoma component in the cerebellar hemisphere, Neuropathology. , 10.1111/neup.12478, in press, 2018.05.
12. Tomohiro Okuda, Nobuhiro Hata, Satoshi O. Suzuki, Koji Yoshimoto, Koichi Arimura, Takeo Amemiya, Yojiro Akagi, Daisuke Kuga, Utako Oba, Yuhki Koga, Shouichi Ohga, Toru Iwaki, Koji Iihara, Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord, Neuropathology. , 10.1111/neup.12471, in press, 2018.04.
13. Reiji Hommyo, Satoshi O. Suzuki, Nona Abolhassani, Hideomi Hamasaki, Masahiro Shijo, Norihisa Maeda, Hiroyuki Honda, Yusaku Nakabeppu, Toru Iwaki, Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis., Neuropathology. , 10.1111/neup.12466, 38, 3, 247-259, 2018.01.
14. Yojiro Akagi, Koji Yoshimoto, Nobuhiro Hata, Daisuke Kuga, Ryusuke Hatae, Takeo Amemiya, Yuhei Sangatsuda, Satoshi O. Suzuki, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara, Reclassification of 400 consecutive glioma cases based on the revised 2016WHO classification., Brain Tumor Pathol., 10.1007/s10014-018-0313-4, 35, 2, 81-89, 2018.04.
15. Ryota Kurogi, Akira Nakamizo, Satoshi O. Suzuki, Masahiro Mizoguchi, Koji Yoshimoto, Toshiyuki Amano, Takeo Amemiya, So Takagishi, Koji Iihara, Inhibition of glioblastoma cell invasion by hsa-miR-145-5p and hsa-miR-31-5p co-overexpression in human mesenchymal stem cells., J Neurosurg. , 10.3171/2017.8.JNS1788, in press, 2018.03.
16. Hiroyuki Honda, Naokazu Sasagasako, Chang Shen, Masahiro Shijo, Hideomi Hamasaki, Satoshi O.Suzuki, Yoshio Tsuboi, Naoki Fujii, Toru Iwaki, DCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy., Parkinsonism Relat Disord., 10.1016/j.parkreldis.2018.02.038, S1353-8020(18)30090-7, 2018.02.
17. Nobuya Murakami, Takato Morioka, Takafumi Shimogawa, Kimiaki Hashiguchi, Nobutaka Mukae, Kazuyoshi Uchihashi, Satoshi O. Suzuki, Koji Iihara, Retained medullary cord extending to a sacral subcutaneous meningocele., Childs Nerv Syst., 10.1007/s00381-017-3644-2, 34, 3, 527-533, 2018.03.
18. Takato Morioka, Satoshi O Suzuki, Nobuya Murakami, Takafumi Shimogawa, Nobutaka Mukae, Satoshi Inoha, Takakazu Sasaguri, Koji Iihara, Neurosurgical pathology of limited dorsal myeloschisis., Childs Nerv Syst., 10.1007/s00381-017-3625-5, 34, 2, 293-303, 2018.02.
19. Mihori Ryorin, Takato Morioka, Nobuya Murakami, Satoshi O Suzuki, Nobuko Kawamura, Dynamic morphological changes of thrombosed lateral sinus pericranii revealed by serial magnetic resonance images., Childs Nerv Syst., 10.1007/s00381-017-3592-x, 34, 1, 143-148, 2018.01.
20. Koji Yoshimoto, Ryusuke Hatae, Satoshi O Suzuki, Nobuhiro Hata, Daisuke Kuga, Yojiro Akagi, Takeo Amamiya, Yuhei Sangetsuda, Nobutaka Mukae, Masahiro Mizoguchi, Toru Iwaki, Koji Iihara, High-resolution melting and immunohistochemical analysis efficiently detects mutually exclusive genetic alterations of adamantinomatous and papillary craniopharyngiomas., Neuropathology., doi: 10.1111/neup.12408., 38, 1, 3-10, 2018.02.
21. Koji Yoshimoto, Ryusuke Hatae, Yuhei Sangetsuda, Satoshi O Suzuki, Nobuhiro Hata, Yojiro Akagi, DAISUKE KUGA, Hideki Murata, Koji Yamashita, Osamu Togao, Hiwatashi Akio, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara, Prevalence and clinicopathological features of H3.3 G34-mutant high-grade gliomas: a retrospective study of 411 consecutive glioma cases in a single institution., Brain Tumor Pathol., doi: 10.1007/s10014-017-0287-7, in press, 2017.04.
22. Takato Morioka, Nobuya Murakami, Takafumi Shimogawa, Mukae Nobutaka, KIMIAKI HASHIGUCHI, Satoshi O Suzuki, Koji Iihara, Neurosurgical management and pathology of lumbosacral lipomas with tethered cord., Neuropathology, doi: 10.1111/neup.12382, in press, 2017.04.
23. Iwao Takeshita, Satoshi O Suzuki, Toru Iwaki, [Idiopathic Intracranial Hypotension]., Brain Nerve., doi: 10.11477/mf.1416200654, 69, 2, 143-150, 2017.02.
24. Masahiro Shijo, Hiroyuki Honda, Satoshi O Suzuki, Hideomi Hamasaki, Masao Hokama, Abolhassani Nona, Yusaku Nakabeppu, Toshiharu Ninomiya, Kitazono T, Toru Iwaki, Association of adipocyte enhancer-binding protein 1 with Alzheimer's disease pathology in human hippocampi., Brain Pathol., doi: 10.1111/bpa, in press, 2016.12.
25. Ryusuke Hatae, Nobuhiro Hata, Satoshi O Suzuki, Koji Yoshimoto, DAISUKE KUGA, Hideki Murata, Yojiro Akagi, Yuhei Sangetsuda, Toru Iwaki, Masahiro Mizoguchi, Koji Iihara, A comprehensive analysis identifies BRAF hotspot mutations associated with gliomas with peculiar epithelial morphology., Neuropathology, 10.1111/neup.12347, 37, 3, 191-199, 2017.06.
26. Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Sachiko Koyama, Satoshi O Suzuki, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Toru Iwaki, Recent Increases in Hippocampal Tau Pathology in the Aging Japanese Population: The Hisayama Study., J Alzheimers Dis., 10.3233/JAD-160521, in press, 2016.02.
27. Nobuya Murakami, Takato Morioka, Satoshi O Suzuki, Mukae Nobutaka, KIMIAKI HASHIGUCHI, Koji Iihara, Tadpole-shaped lateralized parietal atretic cephalocele associated with an ipsilateral lacrimal gland fistula and schizencephalic clefts., Childs Nerv Syst., 10.1007/s00381-016-3254-4, in press, 2016.10.
28. Hiroyuki Honda, Kosuke Matsuzono, Soichiro Fushimi, Kota Sato, Satoshi O Suzuki, Koji Abe, Toru Iwaki, C-Terminal-Deleted Prion Protein Fragment Is a Major Accumulated Component of Systemic PrP Deposits in Hereditary Prion Disease With a 2-Bp (CT) Deletion in PRNP Codon 178., J Neuropathol Exp Neurol, in press, in press, 2016.09.
29. Ryosuke Hatae, Nobuhiro Hata, Koji Yoshimoto, DAISUKE KUGA, Yojiro Akagi, Hideki Murata, Satoshi O Suzuki, Masahiro Mizoguchi, Koji Iihara, Precise Detection of IDH1/2 and BRAF Hotspot Mutations in Clinical Glioma Tissues by a Differential Calculus Analysis of High-Resolution Melting Data., PLos One, 10.1371/journal.pone.0160489, 11, 8, e0160489, 11(8):e0160489, 2016.08.
30. Takafumi Shimogawa, Takato Morioka, Hisasuke Onozawa, Satoshi O Suzuki, Ryutaro Kira, Nasal Dermal Sinus Associated with a Dumbbell-Shaped Dermoid: A Case Report., J Neurol Surg Rep., 10.1055/s-0036-1584525, in press, 2016.07.
31. Nobuya Murakami, Takato Morioka, Nobuko Kawamura, Satoshi O Suzuki, Ryutaro Kira, Venous anomaly analogous to vertical embryonic positioning of the straight sinus associated with atretic cephalocele at the suboccipital region., Childs Nerv Syst., 10.1007/s00381-016-3134-y, in press, 2016.07.
32. Shotaro Hayashida, Masaki Katsuhisa, Tomomi Yonekawa, Satoshi O Suzuki, Hiwatashi Akio, Takuya Matsushita, Mitsuru Watanabe, Ryo Yamasaki, Toshihiko Suenaga, Toru Iwaki, Hiroyuki Murai, Jun-ichi Kira, Early and Extensive Spinal White Matter Involvement in Neuromyelitis Optica., Brain Pathol, 10.1111/bpa.12386, in press, 2016.04.
33. Hiroyuki Honda, Kensuke Sasaki, Hideomi Hamasaki, Masahiro Shijo, Sachiko Koyama, Tomoyuki Ohara, Toshiharu Ninomiya, Yutaka Kiyohara, Satoshi O Suzuki, Toru Iwaki, Trends in autopsy-verified dementia prevalence over 29 years of the Hisayama study., Neuropathology, 10.1111/neup.12298, in press, 2016.02.
34. NISHIO MIKI, Keishi Sugimachi, Hiroki Goto, Jia Wang, Takumi Morikawa, Yosuke Miyachi, Yusuke Takano, Hiroki Hikasa, Tohru Itoh, Satoshi O Suzuki, Hiroki Kurihara, Shinichi Aishima, Andrew Leask, Takehiko Sasaki, Toru Nakano, Hiroshi Nishina, Yuji Nishikawa, Yoshitaka Sekido, Kazuwa Nakao, Kazuo Shin-ya, Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice., Proc Natl Acad Sci U S A, 0.1073/pnas.1517188113., 113, 1, E71-E80, 2016.01.
35. Mukae Nobutaka, Satoshi O Suzuki, Takato Morioka, Nobuya Murakami, KIMIAKI HASHIGUCHI, Hiroshi Shigeto, Ayumi Sakata, Koji Iihara, ILAE focal cortical dysplasia type IIIc in the ictal onset zone in epileptic patients with solitary meningioangiomatosis, Epileptic Disord, 10.1684/epd.2014.0695, 2014.11.
36. Nobuhiro Hata, Satoshi O Suzuki, Hideki Murata, Ryusuke Hatae, Yojiro Akagi, Yuhei Sangatsuda, TOSHIYUKI AMANO, Koji Yoshimoto, Tomoko Tahira, Masahiro Mizoguchi, Genetic Analysis of a Case of Glioblastoma with Oligodendroglial Component Arising During the Progression of Diffuse Astrocytoma, Pathol Oncol Res, 10.1007/s12253-014-9850-2, 2014.10.
37. Tomihiro Wakamiya, Satoshi O Suzuki, Hideomi Hamasaki, Hiroyuki Honda, Masahiro Mizoguchi, Koji Yoshimoto, Toru Iwaki, Elevated expression of fatty acid synthase and nuclear localization of carnitine palmitoyltransferase 1C are common among human gliomas., Neuropathology, in press, 2014.07, Fatty acid synthase (FASN) and carnitine palmitoyltransferase 1C (CPT1C), a brain-specific isoform of the CPT1 family, are upregulated in certain types of cancers, including gliomas. Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis, and its phosphorylated form inhibits lipid synthesis. We examined the expression and subcellular localization of these fatty acid metabolism-related molecules in human gliomas. We performed immunostaining of two glioma cell lines (U373MG and U87MG) and 41 surgical specimens of diffuse gliomas with various histological grades (21 with the isocitrate dehydrogenase 1(IDH1) R132H mutation and 20 without the mutation). In the cultured glioma cells, CPT1C and phosphorylated ACC (p-ACC) were mainly localized to the nuclei, whereas FASN localized to the cytoplasm. In the surgical specimens, most glioma tissues showed nuclear staining for CPT1C and p-ACC, and cytoplasmic staining for FASN, regardless of the genetic status of IDH1 and the histological grade. Therefore, elevated cytoplasmic expression of FASN and nuclear localization of CPT1C are common among human diffuse gliomas, which may be regulated by the differential phosphorylation status of ACC in the cellular compartment..
38. Shingo Tanaka, Mitsutoshi Nakada, Sumihito Nobusawa, Satoshi O Suzuki, Hemragul Sabit, Katsuyoshi Miyashita, Yutaka Hayashi, Epithelioid glioblastoma arising from pleomorphic xanthoastrocytoma with the BRAF V600E mutation., Brain Tumor Pathology, 31, 172-176, 2014.06, Pleomorphic xanthoastrocytoma (PXA) is classified by the World Health Organization as a grade II astrocytic tumor with relatively favorable prognosis among gliomas. A valine-to-glutamic acid substitution at position 600 of the serine/threonine-protein kinase BRAF (BRAF V600E) mutation, which is commonly found in PXA, has recently been detected in approximately 50 % of all epithelioid glioblastoma (GBM) cases. We herein report a case of epithelioid GBM developing at the site of a left temporal PXA 13 years after the treatment of the primary tumor. The BRAF V600E mutation was detected in both tumors. These findings suggest that epithelioid GBM may arise from a PXA with a BRAF V600E mutation.
39. Masaki Katsuhisa, Satoshi O Suzuki, Takuya Matsushita, Takeshi Matsuoka, Shihoko Imamura, Ryo Yamasaki, Makiko Suzuki, Toshihiko Suenaga, Toru Iwaki, Jun-ichi Kira, Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica., PLoS One, 10.1371/journal.pone.0072919, 8, 8, e72919, 2013.08, BACKGROUND:
Multiple sclerosis (MS) and neuromyelitis optica (NMO) occasionally have an extremely aggressive and debilitating disease course; however, its molecular basis is unknown. This study aimed to determine a relationship between connexin (Cx) pathology and disease aggressiveness in Asian patients with MS and NMO.
Samples included 11 autopsied cases with NMO and NMO spectrum disorder (NMOSD), six with MS, and 20 with other neurological diseases (OND). Methods of analysis included immunohistochemical expression of astrocytic Cx43/Cx30, oligodendrocytic Cx47/Cx32 relative to AQP4 and other astrocytic and oligodendrocytic proteins, extent of demyelination, the vasculocentric deposition of complement and immunoglobulin, and lesion staging by CD68 staining for macrophages. Lesions were classified as actively demyelinating (n=59), chronic active (n=58) and chronic inactive (n=23). Sera from 120 subjects including 30 MS, 30 NMO, 40 OND and 20 healthy controls were examined for anti-Cx43 antibody by cell-based assay. Six NMO/NMOSD and three MS cases showed preferential loss of astrocytic Cx43 beyond the demyelinated areas in actively demyelinating and chronic active lesions, where heterotypic Cx43/Cx47 astrocyte oligodendrocyte gap junctions were extensively lost. Cx43 loss was significantly associated with a rapidly progressive disease course as six of nine cases with Cx43 loss, but none of eight cases without Cx43 loss regardless of disease phenotype, died within two years after disease onset (66.7% vs. 0%, P=0.0090). Overall, five of nine cases with Cx43 loss and none of eight cases without Cx43 loss had distal oligodendrogliopathy characterized by selective myelin associated glycoprotein loss (55.6% vs. 0.0%, P=0.0296). Loss of oligodendrocytic Cx32 and Cx47 expression was observed in most active and chronic lesions from all MS and NMO/NMOSD cases. Cx43-specific antibodies were absent in NMO/NMOSD and MS patients.
These findings suggest that autoantibody-independent astrocytic Cx43 loss may relate to disease aggressiveness and distal oligodendrogliopathy in both MS and NMO..
40. Nobuya Murakami, Takato Morioka, KIMIAKI HASHIGUCHI, Takashi Yoshiura, Hiwatashi Akio, Satoshi O Suzuki, Akira Nakamizo, TOSHIYUKI AMANO, Nobuhiro Hata, Tomio Sasaki, Usefulness of three-dimensional T1-weighted spoiled gradient-recalled echo and three-dimensional heavily T2-weighted images in preoperative evaluation of spinal dysraphism., Childs Nerv Syst, 2013.05.
41. Hiroyuki Honda, Ishii R, Hamano A, Itoh K, Satoshi O Suzuki, Fushiki S, Nakagawa M, Toru Iwaki, Microsphere formation in a subtype of Creutzfeldt-Jakob disease with a V180I mutation and codon 129 MM polymorphism., Neuropathol Appl Neurobiol, 10.1111/nan.12047., 2013.03.
42. Masahiro Mizoguchi, Nobuhiro Hata, Satoshi O Suzuki, Fujioka Y, Murata H, TOSHIYUKI AMANO, Akira Nakamizo, Koji Yoshimoto, Toru Iwaki, Tomio Sasaki, Pediatric glioblastoma with oligodendroglioma component: Aggressive clinical phenotype with distinct molecular characteristics., Neuropathology, doi: 10.1111/neup.12029. , 2013.03.
43. Amran, Muhammad Yunus, Fujii, Jun, Satoshi O Suzuki, Kolling, Glynis L., Villanueva, Sharon Y. A. M., Kainuma, Mosaburo, Kobayashi, Hideyuki, Kameyama, Hideko, Yoshida, Shin-ichi, Investigation of Encephalopathy Caused by Shiga Toxin 2c-Producing Escherichia coli Infection in Mice, PLOS ONE, 10.1371/journal.pone.0058959, 8, 3, e58959, 2013.03.
44. Watanabe S, Shirogane Y, Suzuki SO, Ikegame S, Koga R, Yanagi Y., Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters., J Virol, 87, 5, 2648-59, 2013.03.
45. Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A., Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice., J Clin Invest, 122, 12, 4505-18, 2012.12.
46. Nobuya Murakami, Takato Morioka, Kimiaki Hashiguchi, Satoshi O Suzuki, Takayuki Amano, Ayumi Sakata, Toru Iwaki, Tomio Sasaki, Focal cortical dysplasia of Palmini type IIA as an epileptogenesis in patients with epilepsy associated with Sturge-Weber syndrome

, Epilepsia, in press, 2012.07.
47. Masaki K, Suzuki SO, Matsushita T, Yonekawa T, Matsuoka T, Isobe N, Motomura K, Wu XM, Tabira T, Iwaki T, Kira J., Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction., Acta Neuropathol., 123, 6, 887-900, 2012.06.
48. Satoshi O. Suzuki, Toru Iwaki, Kenji Arakawa, Hirokazu Furuya,, Naoki Fujii, Akiko Iwaki, An autopsy case of adult-onset hereditary spastic paraplegia type 2 with a novel mutation in exon 7 of the proteolipid protein 1 gene, Acta Neuropathol , 22, 6, 775-81, 2011.12.
49. Harada S, Suzuki SO, Seki Y, Nakamura S, Iwaki T. , Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation. , J Oral Pathol Med. in press., 41, 4, 354-60, 2011.10.
50. Yamashita K, Yoshiura T, Hiwatashi A, Togao O, Yoshimoto K, Suzuki SO, Kikuchi K, Mizoguchi M, Iwaki T, Honda H., Arterial spin labeling of hemangioblastoma: differentiation from metastatic brain tumors based on quantitative blood flow measurement.

Neuroradiology. , Neuroradiology. in press, 2011.11.
51. Nakamizo A, Akagi Y, Amano T, Suzuki SO, Otsuka R, Abe Y, Yoshimoto K, Iwaki T, Sasaki T., Donor-derived adult T-cell leukaemia., Lancet. , 377, 9771, 1124, 2011.03.
52. Matsuoka T, Suzuki SO, Toshihiko Suenaga, Iwaki T, Kira JI., Reappraisal of Aquaporin-4 Astrocytopathy in Asian Neuromyelitis
Optica and Multiple Sclerosis Patients, Brain Pathology, in press, 2010.12.
53. Rina Torisu, Satoshi O. Suzuki, Kenta Masui, Koji Yoshimoto, Masahiro Mizoguchi, Makoto Hashizume, Peter Canoll, James E. Goldman, Tomio Sasaki, Toru Iwaki, Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth and anaplastic transformation of gliomas in an in vivo serial transplantation model, Brain Tumor Pathology, 28, 1, 33-42, 28(1):33-42., 2011.02.
54. Masui K, Suzuki SO, Hashiguchi K, Morioka T, Yoshiura T, Sasaki T, Iwaki T., Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood: A case report and reappraisal of the glial component in archival FCD cases., Neuropathology, in press, 2010.12.
55. Matsuoka T, Suzuki SO, Iwaki T, Tabira T, Ordinario AT, Kira JI., Aquaporin-4 astrocytopathy in Baló's disease., Acta Neuropathol, 120, 5, 651-60, 2010 Nov;120(5):651-60, 2010.11.
56. Kenta Masui, Satoshi O. Suzuki, Rina Torisu, James E. Goldman, Peter Canoll, Toru Iwaki, Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation , Glia , 58, 9, 1050-1065, 2010.07.
57. Masui K, Suzuki SO, Kondo A, Iwaki T., A 6-YEAR-OLD GIRL WITH AN EXTRA-AXIAL MASS IN THE MIDDLE CRANIAL FOSSA, Brain Pathol., 20, 269–272, 2010.01.
58. Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K., Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice., Nat Cell Biol. , 11, 8, 958-966, 2009.08.
59. Assanah MC, Bruce JN, Suzuki SO, Chen A, Goldman JE, Canoll P., PDGF stimulates the massive expansion of glial progenitors in the neonatal forebrain., Glia, 57, 16, 1835-1847, 2009.12.
60. Seki Y, Suzuki SO, Nakamura S, Iwaki T., Degenerative and protective reactions of the rat trigeminal motor nucleus after removal of the masseter and temporal muscles., J Oral Pathol Med. , 38, 10, 777-784, 2009.11.
61. Sasaki T, Shono T, Hashiguchi K, Yoshida F, Suzuki SO., Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery. , J Neurosurg, 110, 4, 648-655, 2009.04.
62. Kuga D, Mizoguchi M, Guan Y, Hata N, Yoshimoto K, Shono T, Suzuki SO, Kukita Y, Tahira T, Nagata S, Sasaki T, Hayashi K., Prevalence of copy number neutral LOH in glioblastomas revealed by genome-wide analysis of laser-microdissected tissues. , Neuro Oncol, 10:995-1003, 2008.08.
63. Shono T, Yokoyama N, Uesaka T, Kuroda J, Takeya R, Yamasaki T, Amano T, Mizoguchi M, Suzuki SO, Niiro H, Miyamoto K, Akashi K, Iwaki T, Sumimoto H, Sasaki T. , Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival. , Int J Cancer. 2008;123:787-92., 123:787-92., 2008.08.
64. Masui K, Mawatari SY, Suzuki SO, Iwaki T., Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells., Brain Tumor Pathol., 25(1):1-7, 2008.04.
65. Takase KI, Shigeto H, Suzuki SO, Kikuchi H, Ohyagi Y, Kira JI., Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia., Epilepsia, 49, 6, 997-1010, 2008.03.
66. Suzuki SO, McKenney RJ, Mawatari SY, Mizuguchi M, Mikami A, Iwaki T, Goldman JE, Canoll P,Vallee RB. , Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation., Acta Neuropatholgica, 113(5):591-9, 2007.05.
67. Farin A, Suzuki SO, Weiker M, Goldman JE, Bruce JN, Canoll P, Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis., Glia, 2006;53:799-808, 2006.06.
68. Tanaka Y, Miyamoto S, Suzuki SO, Oki E, Yagi H, Sonoda K, Yamazaki A, Mizushima H, Maehara Y, Mekada E, Nakano H:., Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer., Clin. Cancer. Res., 10.1158/1078-0432.CCR-04-1426, 11, 13, 4783-4792, 11: 4783-4789, 2005, 2005.01.
69. Suzuki SO and Iwaki T, Dynamic analysis of glioma cells: looking into "movement phenotypes"., Neuropathology, 10.1111/j.1440-1789.2005.00626.x, 25, 3, 254-262, 25:254-62, 2005, 2005.01.
70. Matsumoto K, Suzuki SO, Fukui M, Iwaki T, Accumulation of MDM2 in pleomorphic xanthoastrocytomas., Pathol. Int., 10.1111/j.1440-1827.2004.01637.x, 54, 6, 387-391, 54:387-391, 2004, 2004.01.
71. Furuta A, Noda M, Suzuki SO, Goto Y, Kanahori Y, Rothstein J.D., Iwaki T., Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in Kainic acid-induced rat epilepsy, American Journal of Pathology, 10.1016/S0002-9440(10)63705-4, 163, 2, 779-787, 163(2):779-787, 2003.08.
72. Suzuki SO, Goldman JE., Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration., J Neurosci, 23, 10, 4240-4250, 23(10):4240-50., 2003.05.
73. Suzuki OS, Kitai R, Llena J, Lee CS, Goldman EJ, Shafit-Zagardo B., MAP-2e, a novel MAP-2 isoform, is expressed in Gliomas and delineates tumor architecture and patterns of infiltration., J Nuropath and Exp Neurol, 61(5):403-412, 2002, 2002.05.
74. Miyagi, Y., Suzuki, S.O., Iwaki, T., Shima, F., Ishido, K., Araki, T. and Kamikaseda, K., Pleomorphic xanthoastrocytoma with predominantly exophytic growth: case report, Surg Neurol, 10.1016/S0090-3019(01)00565-1, 56, 5, 330-332, 56(5):330-2., 2001.11.
75. Nakayama H, Suzuki S, Hikino S, Tezuka J, Hara T., Multiple cerebral arteriovenous fistulas and malformations in the neonate., Pediatr Neurol, 10.1016/S0887-8994(01)00308-3, 25, 3, 236-238, 25(3):236-8, 2001.09.
76. Miyagi, Y., Suzuki S.O., Iwaki T., Ishido K., Araki T. and Kamikaseda K., Magnetic resonance appearance of multiple intracranial epidermoid cysts: intrathecal seeding of the cysts?, J Neurosurg, 92(4):711-4., 2000.04.
1. Hiroyuki Honda, Chang Shen, Satoshi O Suzuki, Naokazu Sasagasako, Toru Iwaki, Dynactin is involved in Lewy body pathology, The 19th International Congress of Neuropathology, 2018.09.
2. Reiji Honmyo, Satoshi O Suzuki, Nona Abolhassani, Hideomi Hamasaki, Masahiro Shijo, Norihisa Maeda, Hiroyuki Honda, Yusaku Nakabeppu, Toru Iwaki, Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis, The 19th International Congress of Neuropathology, 2018.09.
3. Shinichirou Mori, Akihiro Watanabe, Masahiro Shijo, Hiroyuki Honda, Satoshi O Suzuki, Naokazu Sasagasako, Toru Iwaki, An autopsy case of SPG11 with peculiar p62-immunopositive intracytoplasmic inclusions, The 19th International Congress of Neuropathology, 2018.09.
4. Masahiro Shijo, Masaki Tachibana, Tetsuro Ago, Takanari Kitazono, Hiroyuki Honda, Satoshi O Suzuki, Toru Iwaki, Upregulation of annexin A1 in reactive astrocytes at the boundaries of human brain infarcts, The 19th International Congress of Neuropathology, 2018.09.
5. Hideomi Hamasaki, Hiroyuki Honda, Tsuyoshi Okamoto, Satoshi O Suzuki, Toshiharu Ninomiya, Toru Iwaki, Putaminal tau pathology in the aging Japanese population: The Hisayama study, The 19th International Congress of Neuropathology, 2018.09.
6. Nobuhiro Hata, Masahiro Mizoguchi, Yojiro Akagi, Satoshi O. Suzuki, Daisuke Kuga, Takeo Amemiya, Ryusuke Hatae, Koji Yoshimoto, Toru Iwaki, Koji Iihara, The correlation between 1p 19q and TERT promoter mutation status in IDH-mutant gliomas􏱽􏲨 􏲩􏱴􏱹􏲨􏱽􏱵􏲩􏲢􏱲 􏱷􏱶􏱷􏲢􏱲􏱺􏱹 􏲩􏱷􏱾􏲢􏱶􏱲􏱷􏱲􏱹 􏱶􏱾􏲢, 第36回日本脳腫瘍病理学会, 2018.09.
7. 鈴木 諭, 北川 玲華, 岩城 徹, Anti-tumor effects of metformin against malignant glioma􏱟􏱲􏱹􏲢􏲪􏱹􏱸􏲩􏱽􏱵 􏱴􏲨􏲨􏱴􏱻􏱹􏱺 􏱽􏲨 􏲩􏱴􏱹􏲨􏱽􏱵􏲩􏲢􏱲 􏱷􏱶􏱷􏲢􏱲􏱺􏱹 􏲩􏱷􏱾􏲢􏱶􏱲􏱷􏱲􏱹 􏱶􏱾􏲢, 第35回日本脳腫瘍病理学会, 2018.09.
8. An autopsy case of rheumatoid arthritis and other autoimmune diseases complicated by cerebral amyloid angiopathy-related inflammation.
9. Two biopsy cases of meningioangiomatosis..
10. 23 year old man with progressive behavioral changes and motor dysfunction over a 6 - month time course
Satoshi O. Suzuki and Toru Iwaki.
11. Suzuki SO, Torisu R, Iwaki T. In vitro characterization of sphere-forming glioma "stem" cells-what is the stemness? The VIIIth European Meeting Glial Cells in Health and Disease (London) , September 6, 2007.
12. Suzuki SO, Torisu R, Mori M, Matsumoto K, Mizoguchi M, Masui K, Mawatari S, Sasaki T, Iwaki T. Looking for immunohistochemical markers for gliomatosis cerebri. The 48th Annual Meeting of the Japanese Society of Neuropathology (Tokyo), May 30, 2007.
13. Seki Y, Suzuki SO, Iwaki T. Histopathological study on degenerative and regenerative changes of the trigeminal motor nucleus after removal of the maseter muscles. The 48th Annual Meeting of the Japanese Society of Neuropathology (Tokyo), May 30, 2007.
14. Masui K, Onaka S, Matsumoto K, Shono T, Mizoguchi M, Kondo A, Suzuki SO, Sasaki T, Iwaki T. A case of atypical meningioma associated with reactive hyperplasia of meningeal melanocytes. The 48th Annual Meeting of the Japanese Society of Neuropathology (Tokyo), May 30, 2007.
15. Expression of LIS1, cytoplasmic dynein, dynactin, NudE, NudEL, and NudC in human primary neuroectodermal tumors.
16. Pathology of medulloblastoma.
17. Extent of tumor cell invasion in an autopsy case of glioblastoma evaluated by MAP-2e immunostaining.
18. Glioma Cell Migration and Proliferation on Host Brain Vasculature: A Dynamic Analysis.
19. Histological markers for evaluation of the invasion front in biopsied glioma samples..
20. N-myc downregulated gene 1 (NDRG1) is expressed in developing neural cells in the postnatal brain.
21. Immunohistochemimal analysis on LIS1 expression in astrocyic tumors.
  • Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells.,Brain Tumor Pathol.,25(1):1-7,2008.
Educational Activities
Undergraduate courses: Lectures on Brain tumor pathology and development of the nervous system, research course in the free quarter periods

Postgraduate courses: Supervision of doctor course students
Professional and Outreach Activities
Peer-review of scientific articles
Member of the board of trustees of the Japanes Society of Neuropathology
Member of the board of trustees of the Japan Society of Brain Tumor Pathology
Maintenance of the web site of the laboratory.