| 1. |
Gondo M, Kawai K, Moriguchi Y, Hiwatashi A, Takakura S, Yoshihara K, Morita C, Yamashita M, Eto S, Sudo N., Effects of integrated hospital treatment on the default mode, salience, and frontal-parietal networks in anorexia nervosa: A longitudinal resting-state functional magnetic resonance imaging study., PLoS One., 10.1371/journal.pone.0283318., 18(5):e0283318., 2023.05. |
| 2. |
Nohara N, Yamanaka Y, Matsuoka M, Yamazaki T, Kawai K, Takakura S, Sudo N, Ando T, Matsuyama Y, Byrne S, Dalle Grave R, Cooper Z, Yoshiuchi K., A multi-center, randomized, parallel-group study to compare the efficacy of enhanced cognitive behavior therapy (CBT-E) with treatment as usual (TAU) for anorexia nervosa: study protocol., Biopsychosoc Med., 10.1186/s13030-023-00277-2., 17(1):20., 2023.05. |
| 3. |
Nishihara T, Yoshihara K, Ohashi A, Kuroiwa M, Sudo N., Differences in the presentation of COVID-19-related psychosocial stress and general psychological distress and the relation between the number of care days and these symptoms among Japanese ward staff working exclusively with COVID-19 and support staff., Biopsychosoc Med., 10.1186/s13030-023-00272-7., 17(1):17., 2023.04. |
| 4. |
Saito T, Shibata M, Hirabayashi N, Honda T, Morisaki Y, Anno K, Sudo N, Hosoi M, Ninomiya T., Family dysfunction is associated with chronic pain in a community-dwelling Japanese population: The Hisayama study., Eur J Pain., 10.1002/ejp.2076., 4, 518-529, 2023.04. |
| 5. |
Nishihara T, Yoshihara K, Ohashi A, Kuroiwa M, Sudo N., Occupational stress, psychological distress, physical symptoms, and their interrelationships among frontline nurses caring for COVID-19 patients in Japan., Medicine (Baltimore)., 10.1097/MD.0000000000031687., 101(48):e31687, 2022.12. |
| 6. |
Yokoyama H, Nozaki T, Nishihara T, Sawamoto R, Komaki G, Sudo N., Factors associated with the improvement of body image dissatisfaction of female patients with overweight and obesity during cognitive behavioral therapy., Front Psychiatry., 10.3389/fpsyt.2022.1025946., 13:1025946, 2022.10. |
| 7. |
Yamashita M, Kawai K, Toda K, Aso C, Suematsu T, Yokoyama H, Hata T, Takakura S, Sudo N., Cardiopulmonary exercise testing for patients with anorexia nervosa: a case-control study., Eat Weight Disord., 10.1007/s40519-022-01492-6., 8, 3553-3560, 2022.12. |
| 8. |
Otonari J, Ikezaki H, Furusyo N, Sudo N., Do neuroticism and extraversion personality traits influence disease-specific risk factors for mortality from cancer and cardiovascular disease in a Japanese population?, Journal of Psychosomatic Research, 10.1016/j.jpsychores.2021.110422, 144, 110422, 2021.05. |
| 9. |
Miyata N, Hata T,Takakura S, Yoshihara K, Morita C, Mikami K, Nomoto K, Miyazak Ki, Tsuji H, Sudo N., Metabolomics profile of Japanese female patients with restricting-type anorexia nervosa., Physiology and Behavior, 10.1016/j.physbeh.2020.113204., 228, 113204, 2021.01. |
| 10. |
Kimura-Todani T, Hata T, Miyata N, Takakura S, Yoshihara K, Xue Ting Zhang, Asano Y, Altanzul Altaisaikhan, Tsukahara T, Sudo N., Dietary delivery of acetate to the colon using acylated starches as a carrier exerts anxiolytic effects in mice, Physiology and Behavior, 10.1016/j.physbeh.2020.113004, 223, 113004-113004, 2020.09, Recently, short-chain fatty acids (SCFA) have been shown to play an important role in mediating the gut-brain interaction and thereby participate in the patho-physiological process of stress-related disorders. In the current study, we examined whether SCFA generated in the lower gut affects host metabolic and behavioral characteristics. To determine this, we used special diets containing acylated starches that can reach the colon without being absorbed in the upper gastrointestinal tract of male mice. The delivery of SCFA to the colon using this method induced a substantial increase in acetate, butyrate, and propionate in the cecum. Moreover, the diets containing acylated starches also decreased microbial diversity in the cecum, concomitant with a significant impact on microbial composition. In marble-burying (MB) tests, the mice that consumed diets containing acetylated starches showed a decrease in anxiety-like behavior compared with the mice that consumed diets containing either butyrylated or propionylated starches. Cecal acetate contents were significantly associated with anxiety-like behaviors when evaluated by elevated plus-maze and MB tests. Collectively, these results indicate that gut acetate elevation of a dietary origin may exert anxiolytic effects on behavioral phenotypes of the host.. |
| 11. |
Shimizu M, Kawai K, Yamashita M, Shoji M, Takakura S, Hata T, Nakashima M,Tatsushima K, Tanaka K, Sudo N., Correction to Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa: a case control study, BioPsychoSocial Medicine, 10.1186/s13030-020-00192-w, 14, 18, 2020.08, [This corrects the article DOI: 10.1186/s13030-020-00186-8.].. |
| 12. |
Horie T, Hiraide M, Takakura S, Hata T, Sudo N, Yoshiuchi k., Development of a new Japanese version of the Clinical Impairment Assessment Questionnaire, BioPsychoSocial Medicine, 10.1186/s13030-020-00194-8, 14, 19-19, 2020.08, Background: The Clinical Impairment Assessment questionnaire (CIA) is used to measure the severity of psychosocial impairment in patients with eating disorders. The purpose of the present study was to develop a new Japanese version of the CIA (CIA-J) and to evaluate its reliability and validity. Methods: We translated the sixteen items of the CIA into Japanese, back-translated them into English, and had them verified by a native English speaking professional editor. Participants were 152 Japanese-speaking patients (30.4 ± 10.6 years) under treatment for eating disorders and 173 healthy controls (29.5 ± 8.3 years). In addition to the CIA-J, the participants were asked to answer the Eating Attitudes Test (EAT26), The Positive and Negative Affect Schedule (PANAS), and the Hospital Anxiety and Depression Scale (HADS). We performed confirmatory factor analyses to evaluate the factor structure, calculated the Cronbach's alphas of the CIA-J to assess the reliability, and calculated the correlation coefficients between the CIA-J score and those of EAT26, PANAS, and HADS to assess concurrent validity. We also used a Kruskal-Wallis test followed by Steel-Dwass test to compare the scores of the subtypes of eating disorders and the healthy control group. Results: A three-factor structure was obtained, similar to the original version. The Cronbach's alphas of both the global and subscale scores of the CIA-J were high. The CIA-J had significant positive correlations with the EAT26, the negative affect subscale of the PANAS, and the HADS. The global and subscale scores for all subtypes of eating disorders were significantly higher than those of the healthy control group. Conclusions: The CIA-J was determined to be reliable and valid for assessing the severity of psychosocial impairment in patients with eating disorders.. |
| 13. |
Shibata M, Ninomiya T, Anno K,Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Parenting style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment in adulthood A case-control study, Medicine, 10.1097/MD.0000000000021230, 99, 29, e21230, 2020.07, The aim of this study is to investigate the relation between parenting style and chronic pain and the patients' need for psychosomatic treatment in adulthood.We compared 4 combinations of 2 parenting style subscales, high and low care and overprotection, among the following 4 age- and sex-matched groups: community-dwelling subjects without chronic pain (n = 100), community-dwelling subjects with chronic pain (n = 100), outpatients with chronic pain (n = 50), and inpatients with chronic pain (n = 50). Parenting style was assessed for both the mother and father by use of the Parental Bonding Instrument questionnaire. The parenting style associated with the worst outcome was defined as both low care and high overprotection, as reported in previous studies.The frequency of reported adverse parenting style was significantly higher among chronic pain patients than community-dwelling subjects without chronic pain (all P |
| 14. |
Shimizu M, Kawai K, Yamashita M, Shoji M, Takakura S, Hata T, Nakashima M, Tatsushima K, Tanaka K,Sudo N., Very long chain fatty acids are an important marker of nutritional status in patients with anorexia nervosa a case control study, BioPsychoSocial Medicine, 10.1186/s13030-020-00186-8, 14, 1, 2020.07. |
| 15. |
Ohara C, Sekiguch Ai, Takakura S, Endo Y, Tamura N, Kikuchi H, Maruo K, Sugawara N, Hatano K, Kawanishi H, Funaba M, Sugawara A, Nohara N, Kawa Ki, Fukudo S, Sudo N, Zafra Cooper, Yoshiuchi K, Ando T., Effectiveness of enhanced cognitive behavior therapy for bulimia nervosa in Japan A randomized controlled trial protocol, BioPsychoSocial Medicine, 10.1186/s13030-020-0174-z, 14, 1, 2-2, 2020.02, Background: The effectiveness of psychotherapeutic interventions for eating disorders (EDs) is widely studied in Europe, North America, and Australia/New Zealand. However, few controlled studies and no randomized controlled trials (RCTs) have been conducted in Japan despite the relatively high prevalence of EDs in the Japanese population. The aim of this study is to evaluate the effect of enhanced cognitive behavior therapy (CBT-E), an evidence-supported ED-focused form of cognitive behavior therapy (CBT), for the treatment of bulimia nervosa (BN) in Japan. Methods/design: This multicenter RCT will compare CBT-E with treatment as usual (TAU), which is widely used in Japan. A group of 140 adult outpatients with a Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis of BN, ≥18 years of age, a body mass index (BMI) > 17.5 and |
| 16. |
Takakura S, Suzuyama Aso C, Sudo N, et al., Physical and psychological aspects of anorexia nervosa based on duration of illness: a cross-sectional study., BIOPSYCHOSOCIAL MEDICINE, 13, 32, 2019.12. |
| 17. |
Takakura S, Oka Ｔ, Sudo N., Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome An explorative pilot study, BioPsychoSocial Medicine, 10.1186/s13030-019-0171-2, 13, 1, 2019.12. |
| 18. |
Takakura S, Suzuyama Aso C, Toda K, Hata T, Yamashita M,Sudo N., Physical and psychological aspects of anorexia nervosa based on duration of illness A cross-sectional study, BioPsychoSocial Medicine, 10.1186/s13030-019-0173-0, 13, 1, 2019.12. |
| 19. |
Nishihara T, Nozaki T, Sawamoto R, Komaki G, Miyata N, Hosoi M, Sudo N., Effects of Weight Loss on Sweet Taste Preference and Palatability following Cognitive Behavioral Therapy for Women with Obesity, Obesity Facts, 10.1159/000502236, 12, 5, 529-542, 2019.10. |
| 20. |
Hata T,Miyata N,Takakura S, Yoshihara K,Asano Y, Kimura-Todani T, Yamashita M, Xue Ting Zhang, Watanabe N, Mikami K, Koga Y,Sudo N., The Gut Microbiome Derived from Anorexia Nervosa Patients Impairs Weight Gain and Behavioral Performance in Female Mice, Endocrinology, 10.1210/en.2019-00408, 160, 10, 2441-2452, 2019.08. |
| 21. |
Sudo N., Biogenic Amines Signals Between Commensal Microbiota and Gut Physiology, Frontiers in Endocrinology, 10.3389/fendo.2019.00504, 10, 504, 2019.07. |
| 22. |
Furukawa T, Nakano H, Yoshihara K, Sudo N., Predictors of objectively measured snoring in a working population, Sleep and Biological Rhythms, 17, 3, 349-354, 2019.04. |
| 23. |
Sudo N., Role of gut microbiota in brain function and stress-related pathology, Bioscience of Microbiota, Food and Health, 10.12938/bmfh.19-006, 38, 3, 75-80, 2019.03. |
| 24. |
Hiramoto T, Yoshihara K, Asano Y, Sudo N., Protective Role of the Hepatic Vagus Nerve against Liver Metastasis in Mice, NeuroImmunoModulation, 10.1159/000487483, 24, 6, 341-347, 2018.05, OBJECTIVE(S): Although accumulating evidence has shown that the autonomic nervous system is involved in liver pathology, its role in regulating cancer development remains unclear. The purpose of this study was to elucidate its detailed mechanisms. METHODS: A mouse model of liver metastasis of colorectal cancer was used. To elucidate the potential mechanisms involved, we examined the effect of selective hepatic vagotomy on the survival rate and liver-to-body weight. We further evaluated the possible involvement of the hepatic sympathetic nerve fibers in this model. RESULTS: The mortality rate and the liver-to-body weight ratio after cancer inoculation were significantly higher in the vagotomized mice than in the sham-operated mice. The vagotomized mice exhibited a transient decrease in hepatic norepinephrine levels following cancer inoculation. Interestingly, the vagotomy-induced exacerbation of liver metastasis was attenuated by supplementary norepinephrine or phenylephrine, a selective α1-adrenoceptor agonist, but not by clonidine, a selective α2-adrenoceptor agonist. CONCLUSION: Collectively, these results suggest that the hepatic vagus nerve may play a protective role against liver metastasis. Hepatic sympathetic nerves may also be involved as a protective efferent loop, possibly acting through the α1-adrenoceptor.. |
| 25. |
Oka T, Tanahashi T, Sudo N, Battuvshin Lkhagvasuren,Yamada Y., Changes in fatigue, autonomic functions, and blood biomarkers due to sitting isometric yoga in patients with chronic fatigue syndrome, BioPsychoSocial Medicine, 10.1186/s13030-018-0123-2, 12, 1, 2018.04. |
| 26. |
Ohgidani M, A. Kato T, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, Iwaki R, Sagata N, Hashimoto R, Inoue K, Sudo N, Kanba S., Fibromyalgia and microglial TNF-α Translational research using human blood induced microglia-like cells, Scientific reports, 10.1038/s41598-017-11506-4, 7, 1, 2017.12. |
| 27. |
Hata T, Asano Y, Yoshihara K, Kimura-Todani T, Miyata N, Xue Ting Zhang, Takakura S, Aiba Y, Koga Y, Sudo N., Regulation of gut luminal serotonin by commensal microbiota in mice, PloS one, 10.1371/journal.pone.0180745, 12, 7, e0180745, 2017.07, Gut lumen serotonin (5-hydroxytryptamine: 5-HT) contributes to several gastrointestinal functions such as peristaltic reflexes. 5-HT is released from enterochromaffin (EC) cells in response to a number of stimuli, including signals from the gut microbiota. However, the specific mechanism by which the gut microbiota regulates 5-HT levels in the gut lumen has not yet been clarified. Our previous work with gnotobiotic mice showed that free catecholamines can be produced by the deconjugation of conjugated catecholamines; hence, we speculated that deconjugation by bacterial enzymes may be one of the mechanisms whereby gut microbes can produce free 5-HT in the gut lumen. In this study, we tested this hypothesis using germ-free (GF) mice and gnotobiotic mice recolonized with specific pathogen-free (SPF) fecal flora (EX-GF). The 5-HT levels in the lumens of the cecum and colon were significantly lower in the GF mice than in the EX-GF mice. Moreover, these levels were rapidly increased, within only 3 days after exposure to SPF microbiota. The majority of 5-HT was in an unconjugated, free form in the EX-GF mice, whereas approximately 50% of the 5-HT was found in the conjugated form in the GF mice. These results further support the current view that the gut microbiota plays a crucial role in promoting the production of biologically active, free 5-HT. The deconjugation of glucuronide-conjugated 5-HT by bacterial enzymes is likely one of the mechanisms contributing to free 5-HT production in the gut lumen.. |
| 28. |
Sawamoto R, Nozaki T, Nishihara T,Furukawa T, Hata , Komaki G, Sudo N., Predictors of successful long-term weight loss maintenance A two-year follow-up, BioPsychoSocial Medicine, 10.1186/s13030-017-0099-3, 11, 1, 2017.06. |
| 29. |
Sudo N., Cross-talk between immune system and brain, Japanese Journal of Allergology, 6, 3, 147-152, 2017.05. |
| 30. |
Kawai K, Nakashima M, Kojima M, Yamashita S, Takakura S, Shimizu M, Kubo C, Sudo N., Ghrelin activation and neuropeptide Y elevation in response to medium chain triglyceride administration in anorexia nervosa patients, Clinical Nutrition ESPEN, 10.1016/j.clnesp.2016.10.001, 17, 100-104, 2017.02. |
| 31. |
Michelle G. Rooks, Patrick Veiga, Analise Z. Reeve, Sydney Lavoie, Yasuda K, Asano Y, Yoshihara K, Michaud M, Leslie Wardwell-Scott, Carey Ann Gallini, Jonathan N. Glickman, Sudo N, Curtis Huttenhower, Cammie F. Lesser, Wendy S. Garretta, QseC inhibition as an antivirulence approach for colitis-associated bacteria, Proceedings of the National Academy of Sciences of the United States of America, 10.1073/pnas.1612836114, 114, 1, 142-147, 2017.01. |
| 32. |
Koga Y, Tokunaga S, Nagano J, Sato F, Konishi K, Tochio T, Murakam Yi, Masumoto N, Tezuka J, Sudo N, Kubo C, Shibata R., Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants, Pediatric Research, 10.1038/pr.2016.167, 80, 6, 844-851, 2016.12, BACKGROUND: Although Faecalibacterium prausnitzii is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear. METHODS: The counts of F. prausnitzii in the feces were examined by real-time polymerase chain reaction (PCR). Fecal samples were obtained from 65 atopic dermatitis (AD) infants who participated in a randomized controlled clinical trial to investigate the therapeutic effect of kestose, the smallest fructooligosaccharide. RESULTS: Although the F. prausnitzii count was undetectable level in most 0- to 1-y-old infants, the count reached a level comparable to that in adults in 2- to 5-y-old infants. The bacterial number increased about 10-fold by oral administration of kestose every day for 12 wk in the younger infants, but not so much in the older infants. This bacterial increase was significantly correlated with an improvement in the AD symptoms in the older infants. CONCLUSION: The F. prausnitzii population in the intestine reaches a level comparable to that in adult at approximately 2 y of age. Kestose efficiently stimulates the growth of this bacterium in the intestine, which might lead to an improvement in AD symptoms in infants.. |
| 33. |
Hayaki C, Anno K, Shibata M, Iwaki R, Kawata H, Sudo N, Hosoi M., Family dysfunction A comparison of chronic widespread pain and chronic localized pain, Medicine (United States), 10.1097/MD.0000000000005495, 95, 49, e5495, 2016.12. |
| 34. |
Furukawa T, Nakano H, Yoshihara K, Sudo N., The relationship between snoring sound intensity and morning blood pressure in workers, Journal of Clinical Sleep Medicine, 10.5664/jcsm.6340, 12, 12, 1601-1606, 2016.12, STUDY OBJECTIVES: This study aimed to determine the consequences of snoring independent of obstructive sleep apnea (OSA) and hypothesized that snoring sound intensity, as assessed by mean tracheal sound (TS) energy (Leq), is related to morning blood pressure (BP). METHODS: A home-based TS monitoring study was performed for two nights on 191 workers in Japan using an IC recorder. Leq and the respiratory disturbance index (RDI) were calculated from the TS data. RDI was used as a marker of OSA severity. Systolic and diastolic BP measurements in the evening and morning (eSBP/eDBP and mSBP/mDBP, respectively) were done before and after TS recording. The data of the second night were analyzed. RESULTS: Leq was significantly related to both mSBP and mDBP (r = 0.32, p |
| 35. |
Hirabayashi N,Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T., Association between diabetes and hippocampal atrophy in Elderly Japanese The Hisayama study, Diabetes care, 10.2337/dc15-2800, 39, 9, 1543-1549, 2016.09, OBJECTIVE: To investigate the association between diabetes and brain or hippocampal atrophy in an elderly population. RESEARCH DESIGN AND METHODS: A total of 1,238 community-dwelling Japanese subjects aged ≥65 years underwent brain MRI scans and a comprehensive health examination in 2012. Total brain volume (TBV), intracranial volume (ICV), and hippocampal volume (HV) were measured using MRI scans for each subject. We examined the associations between diabetes-related parameters and the ratios of TBV to ICV (an indicator of global brain atrophy), HV to ICV (an indicator of hippocampal atrophy), and HV to TBV (an indicator of hippocampal atrophy beyond global brain atrophy) after adjustment for other potential confounders. RESULTS: The multivariable-adjusted mean values of the TBV-to-ICV, HV-to-ICV, and HV-to-TBV ratios were significantly lower in the subjects with diabetes compared with those without diabetes (77.6% vs. 78.2% for the TBV-to-ICV ratio, 0.513% vs. 0.529% for the HV-to-ICV ratio, and 0.660% vs. 0.676% for the HV-to-TBV ratio; all P |
| 36. |
Sawamoto R, Nagano J, Kajiwara E, Sonoda J, Hiramoto T,Sudo N., Inhibition of emotional needs and emotional wellbeing predict disease progression of chronic hepatitis C patients An 8-year prospective study, BioPsychoSocial Medicine, 10.1186/s13030-016-0075-3, 10, 1, 24-24, 2016.07, BACKGROUND: The role of psycosocial factors in the disease progression of chronic hepatitis C (CHC) patients remains unclear. The aim of the present study was to prospectively evaluate the prognostic value of behavioral patterns and the quality of life (QOL) of patients with CHC. METHODS: Two hundred and forty Japanese CHC patients (mean age 62.4 years) were assessed for behavioral patterns (Stress Inventory), QOL (Functional Assessment of Chronic Illness Therapy-Spiritual), and known prognostic factors at baseline then followed for a maximum of 8 years for disease progression, defined as either the first diagnosis of hepatocellular carcinoma (HCC) or hepatitis-related death. RESULTS: Forty-nine events occurred during the study period (46 newly diagnosed HCC cases, three hepatitis-related deaths). In a Cox proportional hazard model including known prognostic factors and treatment-related factors as time-dependent variables, behavioral patterns associated with inhibition of emotional needs (hazard ratio (HR): 1.35; 95 % confidence interval (CI): 1.02-1.77; p = 0.036) and QOL, representing emotional wellbeing (HR 0.60; 95 % CI 0.37-0.98; p = 0.041), were each associated with the risk of disease progression. CONCLUSION: Psychosocial factors such as behavioral patterns relevant to the inhibition of emotional needs and emotional wellbeing independently affect the clinical course of patients with CHC.. |
| 37. |
Yoshihara K, C. Tanabe H, Kawamichi H, Koike T, Yamazaki M, Sudo N, Sadato N., Neural correlates of fear-induced sympathetic response associated with the peripheral temperature change rate, NeuroImage, 10.1016/j.neuroimage.2016.04.040, 134, 522-531, 2016.07, Activation of the sympathetic nervous system is essential for coping with environmental stressors such as fearful stimuli. Recent human imaging studies demonstrated that activity in some cortical regions, such as the anterior cingulate cortex (ACC) and anterior insula cortex (aIC), is related to sympathetic activity. However, little is known about the functional brain connectivity related to sympathetic response to fearful stimuli. The participants were 32 healthy, right-handed volunteers. Functional magnetic resonance imaging (fMRI) was used to examine brain activity when watching horror and control movies. Fingertip temperature was taken during the scanning as a measure of sympathetic response. The movies were watched a second time, and the degree of fear (9-point Likert-type scale) was evaluated every three seconds. The brain activity of the ACC, bilateral aIC, and bilateral anterior prefrontal cortex (aPFC) was correlated with the change rate of fingertip temperature, with or without fearful stimuli. Functional connectivity analysis revealed significantly greater positive functional connectivity between the amygdala and the ACC and between the amygdala and the aIC when watching the horror movie than when watching the control movie. Whole-brain psycho-physiological interaction (PPI) analysis revealed that the functional connectivity between the left amygdala and the ACC was modulated according to the fear rating. Our results indicate that the increased functional connectivity between the left amygdala and the ACC represents a sympathetic response to fearful stimuli.. |
| 38. |
Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood The Hisayama Study, BMC Psychiatry, 10.1186/s12888-016-0926-2, 16, 1, 2016.07. |
| 39. |
Sawamoto R, Nozaki T,Furukawa T, Tanahashi T, Morita C, Hata T, Nakashima M, Komaki G, Sudo N.
, A change in objective sleep duration is associated with a change in the serum adiponectin level of women with overweight or obesity undergoing weight loss intervention, Obesity Science and Practice, 10.1002/osp4.32, 2, 2, 180-188, 2016.06. |
| 40. |
Sudo N., Effects of gut microbiota on stress response and behavioral phenotype of the host, Brain and Nerve, 68, 6, 595-605, 2016.06. |
| 41. |
Sudo N., The Hypothalamic-Pituitary-Adrenal Axis and Gut Microbiota
A Target for Dietary Intervention?, The Gut-Brain Axis Dietary, Probiotic, and Prebiotic Interventions on the Microbiota, 10.1016/B978-0-12-802304-4.00013-X, 293-304, 2016.06. |
| 42. |
Sawamoto R, Nozaki T, Furukawa T, Tanahashi T, Morita C, Hata T, Komaki G, Sudo N., Predictors of dropout by female obese patients treated with a group cognitive behavioral therapy to promote weight loss, Obesity Facts, 10.1159/000442761, 9, 1, 29-38, 2016.03. |
| 43. |
Morita C, Tsuji H, Hata T, Gondo M, Takakura S, Kawa Ki,Yoshihara K, Ogata K, Nomoto K, Miyazaki K, Sudo N., Gut Dysbiosis in Patients with Anorexia Nervosa, PloS one, 10.1371/journal.pone.0145274, 10, 12, e0145274, 2015.12. |
| 44. |
Takakura S, Yokoyama H, Suzuyama C,Tatsushima K, Yamashita M, Gondou M, Morita C, Hata T, Takii M, Kawai K, Sudo N., Three cases of appendicitis with anorexia nervosa under inpatient care, Journal of Eating Disorders, 10.1186/s40337-015-0076-9, 3, 1, 2015.11. |
| 45. |
Chijiwa T,Oka T, Battuvshin Lkhagvasuren, Yoshihara K, Sudo N., Prior chronic stress induces persistent polyI C-induced allodynia and depressive-like behavior in rats: Possible involvement of glucocorticoids and microglia, Physiology and Behavior, 10.1016/j.physbeh.2015.04.050, 147, 264-273, 2015.08, When animals suffer from viral infections, they develop a set of symptoms known as the "sickness response." Recent studies suggest that psychological stress can modulate the sickness response. However, it remains uncertain whether acute and chronic psychosocial stresses have the same effect on viral infection-induced sickness responses. To address this question, we compared changes in polyI:C-induced sickness responses, such as fever, change of body weight and food intake, mechanical allodynia, and depressive-like behavior, in rats that had been pre-exposed to single and repeated social defeat stresses. Intraperitoneal injection of polyI:C induced a maximal fever of 38.0°C 3h after injection. Rats exposed to prior social defeat stress exhibited blunted febrile responses, which were more pronounced in the repeated stress group. Furthermore, only the repeated stress group showed late-onset and prolonged mechanical allodynia lasting until 8days after injection in the von Frey test and prolonged immobility time in the forced swim test 9days post-injection. To assess the role of glucocorticoids and microglia in the delayed and persistent development of these sickness responses in rats exposed to repeated stress, we investigated the effect of pretreatment with RU486, a glucocorticoid receptor antagonist, and minocycline, an inhibitor of microglial activation, on polyI:C-induced allodynia and depressive-like behavior. Pretreatment with either drug inhibited both the delayed allodynia and depressive-like behavior. The present study demonstrates that repeated, but not single, social defeat stress followed by systemic polyI:C administration induced prolonged allodynia and depressive-like behavior in rats. Our results show that even though a single-event psychosocial stress does not have any effect by itself, animals may develop persistent allodynia and depressive-like behavior when they suffer from an infectious disease if they are pre-exposed to repeated or chronic psychosocial stress. Furthermore, this study suggests that stress-induced corticosterone and microglial activation play a pivotal role in this phenomenon.. |
| 46. |
Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population The Hisayama Study, BMC Psychiatry, 10.1186/s12888-015-0574-y, 15, 1, 2015.07, However, the relationship. |
| 47. |
Sudo N., Brain-gut axis and gut microbiota Possible role of gut microbiota in childhood mental health and diseases, Journal of Pediatric Biochemistry, 10.1055/s-0035-1564579, 5, 2, 77-80, 2015.06. |
| 48. |
Nagano J, Sudo N, Nagaoka S, Yukioka M, Kondo M., Life events, emotional responsiveness, and the functional prognosis of patients with rheumatoid arthritis, BioPsychoSocial Medicine, 10.1186/s13030-015-0043-3, 9, 1, 15-15, 2015.06, BACKGROUND: Stressors may differently affect human physiological systems according to the host properties relevant to psycho-behavioral processes that the stressors invoke. In a Japanese multicenter cohort study of patients with rheumatoid arthritis (RA), we examined if major life events differently contribute to the patients' functional prognosis according to their ability to identify emotions as manifest feelings when encountering the events (emotional responsiveness). METHODS: 460 patients with RA completed a self-administered baseline questionnaire about psychosocial factors including emotional responsiveness. Two years later, they checked on a list of positive/negative personal events that happened during the two-year study period. Rheumatologists evaluated their functional status at baseline and follow-up using the ACR classification system. RESULTS: In a multiple logistic regression model that included baseline demographic, disease activity/severity-related, therapeutic, and socioeconomic factors as covariates, none of the counts of positive, negative, or all life events was associated with the functional status at follow-up. In the subgroup with poor emotional responsiveness, however, these life event counts were all associated with a poorer functional prognosis (odds ratio of ACR class 3-4 vs. 1-2 associated with one increment in the all life-event count = 2.39, 95 % confidence interval = 1.27-4.48, p = .007), while no such relationship was evident for the rest of the patients. CONCLUSIONS: Major life events, whether positive or negative in nature, may have an impact on the disease course of patients with RA when the patient has poor emotional responsiveness to the event(s).. |
| 49. |
Oka T, Tanahashi T, Chijiwa T, Battuvshin Lkhagvasuren, Sudo N, Oka K., Isometric yoga improves the fatigue and pain of patients with chronic fatigue syndrome who are resistant to conventional therapy A randomized, controlled trial, BioPsychoSocial Medicine, 10.1186/s13030-014-0027-8, 8, 1, 2014.12. |
| 50. |
Sawamoto R, Nozaki T, Furukawa T, Tanahashi T, Morita C , Hata T, Komaki G, Sudo N., Higher sleep fragmentation predicts a lower magnitude of weight loss in overweight and obese women participating in a weight-loss intervention, Nutrition and Diabetes, 10.1038/nutd.2014.41, 4, e144, 2014.10. |
| 51. |
Battuvshin Lkhagvasuren, Tanaka H, Sudo N, Kubo C, Oka T., Characteristics of the orthostatic cardiovascular response in adolescent patients with psychogenic fever, Psychotherapy and Psychosomatics, 10.1159/000360999, 83, 5, 318-319, 2014.08. |
| 52. |
Nozaki T, Sawamoto R, Sudo N., [Cognitive behavioral treatment of obesity--psychosomatic approach of lifestyle modification], Fukuoka igaku zasshi = Hukuoka acta medica, 105, 7, 139-147, 2014.07. |
| 53. |
B. Lkhagvasuren,Oka T, Nakamura Y, Hayashi H, Sudo N,Nakamura K., Distribution of Fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment, Neuroscience, 10.1016/j.neuroscience.2014.04.047, 272, 34-57, 2014.07. |
| 54. |
Sudo N., Microbiome, HPA axis and production of endocrine hormones in the gut, Advances in experimental medicine and biology, 10.1007/978-1-4939-0897-4_8, 817, 177-194, 2014.06. |
| 55. |
Shibata M, Ninomiya T, Mark P. Jensen, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T,Imada Y, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Alexithymia is associated with greater risk of chronic pain and negative affect and with lower life satisfaction in a general population The Hisayama study, PloS one, 10.1371/journal.pone.0090984, 9, 3, e90984, 2014.03, INTRODUCTION: Chronic pain is a significant health problem worldwide, with a prevalence in the general population of approximately 40%. Alexithymia -- the personality trait of having difficulties with emotional awareness and self-regulation -- has been reported to contribute to an increased risk of several chronic diseases and health conditions, and limited research indicates a potential role for alexithymia in the development and maintenance of chronic pain. However, no study has yet examined the associations between alexithymia and chronic pain in the general population. METHODS: We administered measures assessing alexithymia, pain, disability, anxiety, depression, and life satisfaction to 927 adults in Hisayama, Japan. We classified the participants into four groups (low-normal alexithymia, middle-normal alexithymia, high-normal alexithymia, and alexithymic) based on their responses to the alexithymia measure. We calculated the risk estimates for the criterion measures by a logistic regression analysis. RESULTS: Controlling for demographic variables, the odds ratio (OR) for having chronic pain was significantly higher in the high-normal (OR: 1.49, 95% CI: 1.07-2.09) and alexithymic groups (OR: 2.56, 95% CI: 1.47-4.45) compared to the low-normal group. Approximately 40% of the participants belonged to these two high-risk groups. In the subanalyses of the 439 participants with chronic pain, the levels of pain intensity, disability, depression, and anxiety were significantly increased and the degree of life satisfaction was decreased with elevating alexithymia categories. CONCLUSIONS: The findings demonstrate that, in the general population, higher levels of alexithymia are associated with a higher risk of having chronic pain. The early identification and treatment of alexithymia and negative affect may be beneficial in preventing chronic pain and reducing the clinical and economic burdens of chronic pain. Further research is needed to determine if this association is due to a causal effect of alexithymia on the prevalence and severity of chronic pain.. |
| 56. |
Kawai K, Yamashita M, Komaki G, Shimizu M, Nakashima M, Etou S, Takakura S, Takii M, Kubo C, Sudo N., The outcome of treatment for anorexia nervosa inpatients who required urgent hospitalization, BioPsychoSocial Medicine, 10.1186/1751-0759-8-20, 8, 1, 2014.03. |
| 57. |
Yoshihara K, Hiramoto T,Oka T, Kubo C, Sudo N., Effect of 12 weeks of yoga training on the somatization, psychological symptoms, and stress-related biomarkers of healthy women, BioPsychoSocial Medicine, 10.1186/1751-0759-8-1, 8, 1, 1-1, 2014.01, BACKGROUND: Previous studies have shown that the practice of yoga reduces perceived stress and negative feelings and that it improves psychological symptoms. Our previous study also suggested that long-term yoga training improves stress-related psychological symptoms such as anxiety and anger. However, little is known about the beneficial effects of yoga practice on somatization, the most common stress-related physical symptoms, and stress-related biomarkers. We performed a prospective, single arm study to examine the beneficial effects of 12 weeks of yoga training on somatization, psychological symptoms, and stress-related biomarkers. METHODS: We recruited healthy women who had no experience with yoga. The data of 24 participants who were followed during 12 weeks of yoga training were analyzed. Somatization and psychological symptoms were assessed before and after 12 weeks of yoga training using the Profile of Mood State (POMS) and the Symptom Checklist-90-Revised (SCL-90-R) questionnaires. Urinary 8-hydroxydeoxyguanosine (8-OHdG), biopyrrin, and cortisol levels were measured as stress-related biomarkers. The Wilcoxon signed-rank test was used to compare the stress-related biomarkers and the scores of questionnaires before and after 12 weeks of yoga training. RESULTS: After 12 weeks of yoga training, all negative subscale scores (tension-anxiety, depression, anger-hostility, fatigue, and confusion) from the POMS and somatization, anxiety, depression, and hostility from the SCL-90-R were significantly decreased compared with those before starting yoga training. Contrary to our expectation, the urinary 8-OHdG concentration after 12 weeks of yoga training showed a significant increase compared with that before starting yoga training. No significant changes were observed in the levels of urinary biopyrrin and cortisol after the 12 weeks of yoga training. CONCLUSIONS: Yoga training has the potential to reduce the somatization score and the scores related to mental health indicators, such as anxiety, depression, anger, and fatigue. The present findings suggest that yoga can improve somatization and mental health status and has implications for the prevention of psychosomatic symptoms in healthy women. TRIAL REGISTRATION: University Hospital Medical Information Network (UMIN CTR) UMIN000007868.. |
| 58. |
Sawamoto R, Nozaki T, Furukawa T,Tanahashi T, Morita C,Hata T,Komaki G, Sudo N., Higher sleep fragmentation predicts a lower magnitude of weight loss in overweight and obese women participating in a weight-loss intervention, Nutrition and Diabetes, 10.1038/nutd.2014.41, 4, 10, 2014.01. |
| 59. |
Sudo N., Regulation of host stress response by gut microbiota, Skin Research, 12, SUPPL. 20, 37-41, 2013.10. |
| 60. |
Takii M, Uchigata Y, Kishimoto J, Okada A, Matsumoto M,Morita C, Hata T, Nozak Ti,Kawai K,Sudo N., The reliability and validity of a newly developed scale for measuring a negative cognition towards diabetes, Journal of the Japan Diabetes Society, 56, 8, 560-569, 2013.08. |
| 61. |
Nishino R, Mikami K, Takahashi H, Tomonaga S, Hiramoto T, Aiba Y, Koga Y, Sudo N., Commensal microbiota modulate murine behaviors in a strictly contamination-free environment confirmed by culture-based methods, Neurogastroenterology and Motility, 10.1111/nmo.12110, 25, 6, 521-e371, 2013.06. |
| 62. |
Battuvshin Lkhagvasuren,Masuno T, Kanemitsu Y, Sudo N, Kubo C, Oka T., Increased prevalence of postural orthostatic tachycardia syndrome in psychogenic fever patients, Psychotherapy and Psychosomatics, 10.1159/000345171, 82, 4, 269-270, 2013.06. |
| 63. |
Makino S, Mark P. Jensen, Arimura T, Obata T, Anno K,Iwaki R, Kubo C, Sudo N, Hosoi M., Alexithymia and chronic pain The role of negative affectivity, Clinical Journal of Pain, 10.1097/AJP.0b013e3182579c63, 29, 4, 354-361, 2013.04. |
| 64. |
Peng Z, Hiramoto T, Asano Y, Kubo C, Sudo N., Chronic psychological stress exaggerates the compound 48/80-induced scratching behavior of mice, Pharmacology Biochemistry and Behavior, 10.1016/j.pbb.2013.02.014, 105, 173-176, 2013.04. |
| 65. |
Oka T, Kanemitsu Y, Sudo N, Hayashi H, Oka K., Psychological stress contributed to the development of low-grade fever in a patient with chronic fatigue syndrome A case report, BioPsychoSocial Medicine, 10.1186/1751-0759-7-7, 7, 1, 2013.03. |
| 66. |
Asano Y,Hiramoto T, Nishino R, Aiba Y, Kimura T, Yoshihara K, Koga Y, Sudo N., Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice, American Journal of Physiology - Gastrointestinal and Liver Physiology, 10.1152/ajpgi.00341.2012, 303, 11, G1288-G1295, 2012.12. |
| 67. |
Sudo N., Role of microbiome in regulating the HPA axis and its relevance to allergy., Chemical immunology and allergy, 98, 163-175, 2012.12. |
| 68. |
Gondo M, Moriguchi Y, Kodama N, Sato N, Sudo N, Kubo C, Komaki G., Daily physical complaints and hippocampal function An fMRI study of pain modulation by anxiety, NeuroImage, 10.1016/j.neuroimage.2012.07.025, 63, 3, 1011-1019, 2012.11, Pain is a popular physical complaint in human. It is known that experimental anxiety modulates pain processing through hippocampal amplification, whereas it is not known whether a similar experimental reaction is related to daily physical complaints known as 'somatization'. The purpose of this study is to investigate the neural correlates of pain modulation induced by anxiety, particularly in the hippocampus, and how individual differences in this neural reaction relate to somatization. We measured neural response to noxious electrical stimulations, as well as the response to the preceding visual anticipatory cues (which induced low anxiety or high anxiety), by functional magnetic resonance imaging (fMRI). Individual daily physical symptoms were assessed by using the somatization subscale of the Symptom Checklist 90 revised (SCL-90-R). Correlation coefficients between the neural activations and the somatization scores were calculated. We found that manifestation of daily physical symptoms was related to smaller differences in hippocampus activation between high and low anxiety states, suggesting that the ability of the hippocampus to distinguish anxiety states was weakened by the chronic condition that caused the daily physical symptoms. The proper inhibition of neural activation in low anxiety states in the hippocampus and the anterior insula was observed to occur in companionship with lower daily physical complaints. These findings indicate that anxiety's alteration of the network that includes the hippocampus and that is associated with pain modulation underlies the manifestation of somatization.. |
| 69. |
Sudo N., Role of microbiome in regulating the HPA axis and its relevance to allergy., Chem Immunol Allerg, 98, 163-75, 2012.06. |
| 70. |
Iwaki R, Arimura T, Mark P. Jensen, Nakamura T, Yamashiro K, Makino S, Obata T, Sudo N, Kubo C, Hosoi M., Global Catastrophizing vs Catastrophizing Subdomains Assessment and Associations with Patient Functioning, Pain Medicine (United States), 10.1111/j.1526-4637.2012.01353.x, 13, 5, 677-687, 2012.05. |
| 71. |
Tanahashi T, Nagano J, Yamaguchi Y, Kubo C, Sudo N., Factors that predict adherence to continuous positive airway pressure treatment in obstructive sleep apnea patients A prospective study in Japan, Sleep and Biological Rhythms, 10.1111/j.1479-8425.2011.00533.x, 10, 2, 126-135, 2012.04, As adherence to continuous positive airway pressure (CPAP) therapy is crucial in the successful management of obstructive sleep apnea (OSA), identification of the many factors that affect adherence is important. To identify these factors among OSA patients in Japan, a nation with a unique health insurance system, complete sets of data were collected from 101 patients who had undergone overnight diagnostic polysomnography and 6 months of therapy, and the data were subjected to univariate and multivariate analysis. The data included patient responses to sets of questionnaires containing items regarding a variety of factors that the patients had completed before undergoing overnight polysomnography for CPAP titration and initiating use of a treatment device. At the end of the treatment period, the participants were classified into 1 of 3 (non-adherence, poor adherence, and good adherence) CPAP adherence groups for analysis of differences among them. Multiple regression analysis of the variables identified as significant by univariate analysis (adjusted R2= 0.370) indicated that CPAP adherence is positively associated with relatively high sleep efficiency at the time of titration (P |
| 72. |
Arimura T, Hosoi M, Tsukiyama Y, Yoshida T, Fujiwara D, Tanaka M, Tamura R, Nakashima Y, Sudo N, Kubo C., Pain Questionnaire Development Focusing on Cross-Cultural Equivalence to the Original Questionnaire The Japanese Version of the Short-Form McGill Pain Questionnaire, Pain Medicine, 10.1111/j.1526-4637.2012.01333.x, 13, 4, 541-551, 2012.04. |
| 73. |
Amemiya N, Taki Mi, Hata T, Morita C, Takakura S, Oshikiri K,Urabe H, Tokunaga S, Nozaki T, Kawai K, Sudo N, Kubo C., The outcome of Japanese anorexia nervosa patients treated with an inpatient therapy in an internal medicine unit, Eating and Weight Disorders, 10.3275/8034, 17, 1, e1-e8, 2012.03. |
| 74. |
Furukawa T, Sudo N., [Health consequences of snoring and obstructive sleep apnea]., Fukuoka igaku zasshi = Hukuoka acta medica, 103, 1, 1-11, 2012.01. |
| 75. |
Kawai K,Yamashita S, Yamanaka T, Gondo M, Morita C, Nozaki T, Takakura S, Hata T, Yamada Y, Matsubayashi S, Takii M, Kubo C,Sudo N., The longitudinal BMI pattern and body composition of patients with anorexia nervosa who require urgent hospitalization A case control study, BioPsychoSocial Medicine, 5, 14(1)-14(8), 2011.12. |
| 76. |
Battuvshin L, Nakamura Y, Oka T, Sudo N, Nakamura K., Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region, European Journal of Neuroscience, 10.1111/j.1460-9568.2011.07863.x, 34, 9, 1442-1452, 2011.11. |
| 77. |
Yoshihara K, Hiramoto T, Sudo N, Kubo C., Profile of mood states and stress-related biochemical indices in long-term yoga practitioners, BioPsychoSocial Medicine, 10.1186/1751-0759-5-6, 5, 1, 6-6, 2011.06, BACKGROUND: Previous studies have shown the short-term or intermediate-term practice of yoga to be useful for ameliorating several mental disorders and psychosomatic disorders. However, little is known about the long-term influences of yoga on the mental state or stress-related biochemical indices. If yoga training has a stress-reduction effect and also improves an individual's mental states for a long time, long-term yoga practitioners may have a better mental state and lower stress-related biochemical indices in comparison to non-experienced participants. This study simultaneously examined the differences in mental states and urinary stress-related biochemical indices between long-term yoga practitioners and non-experienced participants. METHODS: The participants were 38 healthy females with more than 2 years of experience with yoga (long-term yoga group) and 37 age-matched healthy females who had not participated in yoga (control group). Their mental states were assessed using the Profile of Mood States (POMS) questionnaire. The level of cortisol, 8-hydroxydeoxyguanosine (8-OHdG) and biopyrrin in urine were used as stress-related biochemical indices. RESULTS: The average self-rated mental disturbance, tension-anxiety, anger-hostility, and fatigue scores of the long-term yoga group were lower than those of the control group. There was a trend toward a higher vigor score in the long-term yoga group than that in the control group. There were no significant differences in the scores for depression and confusion in the POMS between the two groups. The urine 8-OHdG concentration showed a trend toward to being lower in the long-term yoga group in comparison to the control group. There were no significant differences in the levels of urine biopyrrin or cortisol. CONCLUSIONS: The present findings suggest that long-term yoga training can reduce the scores related to mental health indicators such as self-rated anxiety, anger, and fatigue.. |
| 78. |
Takii M, Uchigata Y, Kishimoto J, Morita C, Hata T, Nozaki T, Kawai K, Iwamoto Y, Sudo N,Kubo C., The relationship between the age of onset of type 1 diabetes and the subsequent development of a severe eating disorder by female patients, Pediatric Diabetes, 10.1111/j.1399-5448.2010.00708.x, 12, 4 PART 2, 396-401, 2011.06. |
| 79. |
Arimura C, Nozaki T, Takakura S,Kawai K, Takii M, Sudo N, Kubo C., Predictors of menstrual resumption by patients with anorexia nervosa, Eating and Weight Disorders, 10.3275/7039, 15, 4, e226-e233, 2010.12. |
| 80. |
Nagano J, Kakuta C, Motomura C, Odajima H, Sudo N, Nishima S, Kubo C.
, The parenting attitudes and the stress of mothers predict the asthmatic severity of their children A prospective study, BioPsychoSocial Medicine, 10.1186/1751-0759-4-12, 4, 2010.11. |
| 81. |
Furukawa T, Nakano H, Hirayama K, Tanahashi T, Yoshihara K, Sudo N, Kubo C, Nishima S., Relationship between snoring sound intensity and daytime blood pressure, Sleep and Biological Rhythms, 10.1111/j.1479-8425.2010.00455.x, 8, 4, 245-253, 2010.10. |
| 82. |
Forsythe P, Sudo N, Dinan T, Taylor VH, Bienenstock J, Mood and gut feelings, Brain Behav Immun., 24, 1, 9-16, 2010.01. |
| 83. |
Sudo N., Microbiota and brain-gut axis, Fukuoka igaku zasshi = Hukuoka acta medica, 100, 9, 298-304, 2009.09. |
| 84. |
Sudo N., [Functional somatic syndromes in the treatment of allergic diseases and their related disorders]., Nippon rinsho. Japanese journal of clinical medicine, 67, 9, 1755-1758, 2009.09. |
| 85. |
Tanaka F, Nakano H, Sudo N, Kubo C.
, Relationship between the body position-specific apnea-hypopnea index and subjective sleepiness, Respiration, 10.1159/000208727, 78, 2, 185-190, 2009.07. |
| 86. |
Mikami K, Takahashi H, Kimura M, Isozaki M, Izuchi K, Shibata R, Sudo N, Matsumoto H, Koga Y., Influence of maternal bifidobacteria on the establishment of bifidobacteria colonizing the gut in infants, Pediatric Research, 10.1203/PDR.0b013e31819ed7a8, 65, 6, 669-674, 2009.06. |
| 87. |
Hiramoto T, Chida Y, Sonoda J, Yoshihara K,Sudo K,Kubo C., The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor., Gastroenterology, 10.1053/j.gastro.2008.03.005, 134, 7, 2122-31, 134(7):2122-31, 2008.06. |
| 88. |
Chida Y, Steptoe A, Hirakawa N, Sudo N, Kubo C., The effects of psychological intervention on atopic dermatitis A systematic review and meta-analysis, International Archives of Allergy and Immunology, 10.1159/000101940, 144, 1, 1-9, 2007.08. |
| 89. |
Chida Y, Sudo N, Sonoda J, Hiramoto T, Kubo C., Early-life psychological stress exacerbates adult mouse asthma via the hypothalamus-pituitary-adrenal axis., Am J Respir Crit Care Med., 75(4):316-22, 2007.02. |
| 90. |
Sudo N., Stress and gut microbiota Does postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response?, International Congress Series, 10.1016/j.ics.2005.12.019, 1287, 350-354, 2006.04. |
| 91. |
Nagano J, Ichinose Y, Asoh H, Ikeda J, Ohshima A, Sudo N, Kubo C., A prospective Japanese study of the association between personality and the progression of lung cancer., Intern Med, 10.2169/internalmedicine.45.1453, 45, 2, 57-63, 45(2):57-63, 2006.02, Objective To examine predictive values for the effect of the "Type 1" (hopeless and emotion-suppressive, cancer prone), "Type 4" (autonomous, healthy), and "Type 5" (rational/ antiemotional, cancer prone) personalities proposed by Grossarth-Maticek on the prognosis of lung cancer patients.Methods 68 lung cancer patients were scored on the Types 1, 4, and 5 personality scales of the Short Interpersonal Reactions Inventory and were followed until the date of death or were censored at a maximum of 5.7 years after entry.Results The stage at diagnosis tended to be higher in patients with a high Type 1 or a low Type 4 score. A univariate Cox proportional hazards model showed that a high tendency toward Type 1 or Type 5 was related to an increased hazard of death. Adjustment for age, performance status, and stage, however, attenuated the relation to Type 1, leaving only Type 5 as a significantly related personality factor.Conclusion A high Type 5 tendency may predict poor survival in lung cancer patients, whereas Types 1 and 4 may not be independent predictors.. |
| 92. |
Chida Y, Sudo N, Mori J, Kubo C., Social isolation stress impairs passive avoidance learning in senescence-accelerated mouse (SAM)., Brain Res, 2006.01. |
| 93. |
Chida Y, Sudo N, Kubo C., Does stress exacerbate liver diseases?, Journal of Gastroenterology and Hepatology (Australia), 10.1111/j.1440-1746.2006.04110.x, 21, 1 PART2, 202-208, 2006.01. |
| 94. |
Sonoda J, Chida Y, Sudo N, Kubo C., Social disruption stress exacerbates alpha-galactosylceramide-induced hepatitis in mice., Neuroimmunomodulation, 10.1159/000091131, 12, 6, 375-379, 12(6):375-9, 2005.12. |
| 95. |
Chida Y, Sudo N, Takaki A, Kubo C., The hepatic sympathetic nerve plays a critical role in preventing Fas induced liver injury in mice., Gut, 10.1136/gut.2004.058818, 54, 7, 994-1002, 2005.07. |
| 96. |
Chida Y, Sudo N, Kubo C., Psychological stress impairs hepatic blood flow via central CRF receptors in mice., Life Sci, 10.1016/j.lfs.2004.08.032, 76, 15, 1707-1712, 76(15):1707-12, 2005.02. |
| 97. |
Chida Y, Sudo N, Kubo C., Social isolation stress exacerbates autoimmune disease in MRL/lpr mice, Journal of Neuroimmunology, 10.1016/j.jneuroim.2004.09.002, 158, 1-2, 138-144, 158:138-44, 2005.01. |
| 98. |
Chida Y, Sudo N, Motomura Y, Kubo C., Electric foot-shock stress drives TNF-α production in the liver of IL-6-deficient mice, NeuroImmunoModulation, 10.1159/000080153, 11, 6, 419-424, 2004.11. |
| 99. |
Sudo N, Aiba Y, Oyama N, Yu XN, Matsunaga M, Koga Y, Kubo C., Dietary nucleic acid and intestinal microbiota synergistically promote a shift in the Th1/Th2 balance toward Th1-skewed immunity, International Archives of Allergy and Immunology, 10.1159/000080655, 135, 2, 132-135, 135:132-135, 2004, 2004.10. |
| 100. |
Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu XN, Kubo C, Koga Y., Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system fo stress response in mice., Journal of Physiology (London), 10.1113/jphysiol.2004.063388, 558, 1, 263-275, 558, 263-275, 2004.07. |
| 101. |
Chida Y, Sudo N, Sonoda J, Sogawa H, Kubo C., Electric foot-shock stress-induced excerbation of alpha-galactosylceramide-triggered apoptosis in the mouse liver., Hepatology, 10.1002/hep.20158, 39, 4, 1131-1140, 39, 1131-1140, 2004.03. |
| 102. |
Nagano J, Nagase S, Sudo N, Kubo C., Psychosocial Stress, Personality, and the Severity of Chronic Hepatitis C, Psychosomatics, 10.1176/appi.psy.45.2.100, 45, 2, 100-106, 2004.03, This cross-sectional study examined the association between the severity of chronic hepatitis C and the type 1 personality, which has been shown by Grossarth-Maticek to be strongly related to the incidence of cancer and mortality. Sixty-nine patients with chronic hepatitis C completed the Stress Inventory, a self-report questionnaire to measure psychosocial stress and personality, and were classified into three groups according to hepatitis severity: group A, chronic hepatitis C with a normal serum alanine aminotransferase level; group B, chronic hepatitis C with an elevated alanine aminotransferase level; and group C, liver cirrhosis. Each of four scales related to the type 1 personality-low sense of control, object dependence of loss, unfulfilled need for acceptance, and altruism-was significantly and positively associated with hepatitis severity. The type 1 score, calculated as the average of these scales, was also strongly related to hepatitis severity (p |
| 103. |
Hirayama K, Sudo N, Sueyasu M, Sonoda J, Chida Y, Oishi R, Kubo C, Endogenous glucocorticoids inhibit scratching behavior induced by the administration of compound 48/80 in mice, European Journal of Pharmacology, 10.1016/j.ejphar.2003.09.003, 481, 1, 59-65, 481 (1): 59-65, 2003.11. |
| 104. |
Sudo N, Yu XN, Aiba Y, Oyama N, Sonoda J, Koga Y, Kubo C, An oral introduction of intestinal bacteria prevents the development of a long-term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice, Clinical and Experimental Allergy, 10.1046/j.1365-2222.2002.01430.x, 32, 7, 1112-1116, 32 (7): 1112-1116, 2002.07. |
| 105. |
Sudo N, Oyama N, Yu XN, Kubo C, Restraint stress-induced elevation of endogenous glucocorticoids decreases Peyer's patch cell numbers via mechanisms that are either dependent or independent on apoptotic cell death, Neuroimmunomodulation, 10.1159/000059391, 9, 6, 333-339, 9 (6): 333-339, 2001.12. |
| 106. |
Sudo N, X. N. Yu, Kubo C., Dehydroepiandrosterone attenuates the spontaneous elevation of serum IgE level in NC/Nga mice, Immunology Letters, 10.1016/S0165-2478(01)00285-1, 79, 3, 177-179, 2001.12. |
| 107. |
Nagano J, Sudo N, Kubo C, Kono S., Lung cancer, myocardial infarction, and the Grossarth-Maticek personality types a case-control study in Fukuoka, Japan., Journal of Epidemiology, 10.2188/jea.11.281, 11, 6, 281-287, 2001.11, Grossarth-Maticek and colleagues have shown, in their prospective studies, a strong relationship of their personality types, Types 1 and 2, to cancer and coronary heart disease (CHD), respectively. Relevant information is limited from replication studies, and little is known about psychosocial factors in relation to cancer or CHD in Japan. Subjects included 95 cases of lung cancer (LC), 94 cases of myocardial infarction (Ml) and 596 controls. The controls were men and women who visited a clinic for a health checkup. The Grossarth-Maticek personality types, Types 1 to 6, were assessed using the Short Interpersonal Reactions Inventory. The distributions of the 6 personality types were compared between the case and control groups, adjusting for sex and age class. The relation of each of the 6 types to LC and Ml were examined in terms of odds ratio, using a logistic regression model controlling for age, sex, job status, education level, and smoking status. As regards the distribution analysis, Types 1 and 2 in the LC and Ml groups each were not more prevalent than the controls, respectively. High score of the Type 1 scale was associated with a statistically nonsignificant decrease in LC risk. Ml risk was significantly, positively associated with the Type 2 and 5 scales, and unexpectedly, positively related to the Type 3 scale. The present findings partly supported the Grossarth-Maticek theory, but there remain some conflicting issues to be confirmed in future studies.. |
| 108. |
Yu XN, Komaki G, Sudo N, Kubo C, Central and peripheral catecholamines regulate the exercise-induced elevation of plasma interleukin 6 in rats, Life Sciences, 10.1016/S0024-3205(01)01107-9, 69, 2, 167-174, 69 (2): 167-174, 2001.06. |
| 109. |
Nukina H, Sudo N, Aiba Y, Oyama N, Koga Y, Kubo C., Restraint stress elevates the plasma interleukin-6 levels in germ-free mice, Journal of Neuroimmunology, 10.1016/S0165-5728(01)00260-0, 115, 1-2, 46-52, 2001.04. |
| 110. |
Oyama N, Sudo N, Sogawa H, Kubo C, Antibiotic use during infancy promotes a shift in the T(H)1/T(H)2 balance toward T(H)2-dominant immunity in mice, Journal of Allergy and Clinical Immunology, 10.1067/mai.2001.111142, 107, 1, 153-159, 107 (1): 153-159, 2001.01. |
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Sudo N, Aiba Y, Takaki A, Tanaka K, Yu XN, Oyama N, Koga Y, Kubo C, Dietary nucleic acids promote a shift in Th1/Th2 balance toward Th1-dominant immunity, Clinical and Experimental Allergy, 30, 7, 979-987, 2000.07. |
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Nukina H, Sudo N, Komaki G, Yu XN, Mine K, Kubo C, The restraint stress-induced elevation in plasma interleukin-6 negatively regulates the plasma TNF-alpha level, Neuroimmunomodulation, 10.1159/000026352, 5, 6, 323-327, 5 (6): 323-327, 1998.11. |
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Fukui Y, Sudo N, Yu XN, Nukina H, Sogawa H, Kubo C, The restraint stress-induced reduction in lymphocyte cell number in lymphoid organs correlates with the suppression of in vivo antibody production, Journal of Neuroimmunology, 10.1016/S0165-5728(97)00126-4, 79, 2, 211-217, 79 (2): 211-217, 1997.11. |
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Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y., The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction, Journal of Immunology, 159, 4, 1739-1745, 159 (4): 1739-1745, 1997.08. |
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Sudo N, Yu XN, Sogawa H, Kubo C, Restraint stress causes tissue-specific changes in the immune cell distribution, Neuroimmunomodulation, 4, 3, 113-119, 1997.05. |
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Sudo N, Sogawa H, Komaki G, Kubo C, The serotonin-induced elevation of intracellular Ca2+ in human platelets is enhanced by total fasting, Biological Psychiatry, 10.1016/S0006-3223(96)00499-4, 41, 5, 618-620, 41 (5): 618-620, 1997.03. |
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Sudo N, Tanaka K, Koga Y, Okumura Y, Kubo C, Nomoto K, Extracellular ATP activates mast cells via a mechanism that is different from the activation induced by the cross-linking of Fc receptors, Journal of Immunology, 156, 10, 3970-3979, 156 (10): 3970-3979, 1996.05. |
