Kyushu University Academic Staff Educational and Research Activities Database
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Toshiyuki Sasaguri Last modified date:2021.07.19

Professor / Science for Biological Information
Department of Basic Medicine
Faculty of Medical Sciences

Graduate School
Undergraduate School

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Internet site of the Research Ethics Committee Network Fukuoka (RecNet Fukuoka) .
Internet site of the Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University .
Academic Degree
medical doctor
Field of Specialization
pharmacology, clinical pharmacology, internal medicine, research ethics
Research Interests
  • The pharmacological action mechanisms of Dictyostelium differentiation-inducing factor-1 (DIF-1)
    keyword : differentiation-inducing factor-1, cancer, proliferation, differentiation, migration, infiltration, metastasis, MDH2, AMPK, mTORC1
  • Anti-tumor effect of pharmacological inhibitors of the Wnt/β-catenin signal transduction system and its clinical application.
    keyword : differentiation-inducing factors, non-steroidal anti-inflammatory drugs, celecoxib, Wnt/β-catenin signaling pathway, glycogen synthase kinase(GSK)-3, T cell factors (TCF)
  • Effect of GSK-3 activators on cardiac hypertrophy and heart failure and its clinical applications.
    keyword : cardiomyopathy, hypertensive cardiac hypertrophy, heart failure, celecoxib, dimethylcelecoxib
  • Effect of GSK-3 inhibitors on bone diseases and its application to regeneration.
    keyword : GSK-3 inhibitors, lithium, bone injury, bone regeneration
  • Influence of genetic polymorphisms on the pharmacokinetics and pharmacological effects of drugs targeting cardiovascular and other systems.
    keyword : pharmacogenomics, genetic polymorphisms, β-adrenergic receptor antagonists, organic nitrates, diuretics, caffeine
  • Relation between mechanical stresses and vascular disorders
    keyword : mechanical stress, shear stress, stretch stimulation, vascular endothelial cells, vascular smooth muscle cells
  • Pharmacological regulation of myofibroblasts in the wound healing process.
    keyword : myofibroblast, wound healing, staurosporine
  • Research on the pharmacological actions and the clinical application of prostaglandin J2 family
    keyword : prostaglandin D2, prostaglandin D2, vascular smooth muscle, cell proliferation, cell cycle
Academic Activities
1. Takahashi-Yanaga, F. & Sasaguri, T., Drug Development Targeting the Glycogen Synthase Kinase-3beta (GSK-3beta)-Mediated Signal Transduction Pathway: Inhibitors of the Wnt/beta-Catenin Signaling Pathway as Novel Anticancer Drugs., J. Pharmacol. Sci. 109(2), 179-183, 2009.02.
2. Takahashi-Yanaga, F., Sasaguri, T., GSK-3β regulates cyclin D1 expression: A new target for chemotherapy, Cell Signal., 2007.01.
3. Takahashi-Yanaga, F., Sasaguri, T., The Wnt/β-catenin signaling pathway as a target in drug discovery, J. Pharmacol. Sci., 2007.01.
4. Sasaguri, T., Miwa, Y., Prostaglandin J2 family and the cardiovascular system, Current Vascular Pharmacology 2, 103-114, 2004.01.
1. Seto-Tetsuo F, Arioka M, Miura K, Inoue T, Igawa K, Tomooka K, Takahashi-Yanaga F, Sasaguri T., DIF-1 inhibits growth and metastasis of triple-negative breast cancer through AMPK-mediated inhibition of the mTORC1-S6K signaling pathway., Oncogene, 2021.07.
2. Yamamoto M, Takahashi-Yanaga F, Arioka M, Igawa K, Tomooka K, Yamaura K, Sasaguri T., Cardiac and renal protective effects of 2,5-dimethylcelecoxib in angiotensin II and high-salt-induced hypertension model mice., J Hypertens, 10.1097, 39, 5, 892-903, 2021.05.
3. Ohta Y, Kamide K, Hanada H, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Tomohiro Katsuya T, Sugimoto K, Rakugi H, Oukura T, Higaki J, Matsuura H, Shinagawa T, Miwa Y, Sasaguri T, Igase M, Miki T, Takeda K, Higashiura K, Shimamoto K, Katabuchi R, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Iwashima Y, Yoshihara F, Horio T, Nakamura S, Nakahama H, Miyata T, Kawano Y., Genetic factors associated with elevation of uric acid after treatment with thiazide-like diuretic in patients with essential hypertension., Hypertens Res, 43, 3, 220-226, 2020.03.
4. Yoshihara T, Zaitsu M, Kubota S, Arima H, Sasaguri T., Pool walking may improve renal function by suppressing the renin-angiotensin-aldosterone system in healthy pregnant women., Sci Rep, 10, 1, 2891-2891, 2020.01.
5. Tetsuo F, Arioka M, Miura K, Kai M, Kubo M, Igawa K, Tomooka K, Takahashi-Yanaga F, Nishimura F, Sasaguri T., DIF-1 suppresses cyclin D1-induced cell proliferation of MCF-7 breast cancer cells by inhibiting S6K-mediated STAT3 synthesis., Cancer Sci, 110, 12, 3761-3772, 2019.12.
6. Morishige S, Takahashi-Yanaga F, Ishikane S, Arioka M, Igawa K, Kuroo A, Tomooka K, Shiose A, Sasaguri T., 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation., Biochem Pharmacol, in press, 2019.06.
7. Yoshihara T, Zaitsu M, Shiraishi F, Arima H, Takahashi-Yanaga F, Arioka M, Kajioka S, Sasaguri T., Influence of genetic polymorphisms and habitual caffeine intake on the changes in blood pressure, pulse rate, and calculation speed after caffeine intake: A prospective, double blind, randomized trial in healthy volunteers., J Pharmacol Sci, 139, 3, 209-214, 2019.03.
8. Hayamizu K, Morimoto S, Nonaka M, Hoka S, Sasaguri T., Cardiotonic actions of quercetin and its metabolite tamarixetin through a digitalis-like enhancement of Ca2+ transients., Arch Biochem Biophys, 637, 40-47, 2018.01.
9. Arioka M, Takahashi-Yanaga F, Tatsumoto N, Sasaguri T. , Inorganic phosphate-induced impairment of osteoclast cell-cell fusion by the inhibition of AP-1-mediated DC-STAMP expression., Biochem Biophys Res Commun, 493, 1, 9-13, 2017.11.
10. Arioka M, Takahashi-Yanaga F, Kubo M, Igawa K, Tomooka K, Sasaguri T., Anti-tumor effects of differentiation-inducing factor-1 in malignant melanoma: GSK-3-mediated inhibition of cell proliferation and GSK-3-independent suppression of cell migration and invasion., Biochem Pharmacol, 138, 31-48, 2017.08.
11. Nagano A, Arioka M, Takahashi-Yanaga F, Matsuzaki E, Sasaguri T., Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes., J Pharmacol Sci, 133, 1, 18-24, 2017.01.
12. Fujita A, Takahashi-Yanaga F, Morimoto S, Yoshihara T, Arioka M, Igawa K, Tomooka K, Hoka S, Sasaguri T., 2,5-Dimethylcelecoxib prevents pressure-induced left ventricular remodeling through activation of GSK-3., Hypertens Res, 40, 2, 130-139, 2017.02.
13. Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T., Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway., Cancer Sci, 108, 1, 108-115, 2017.01.
14. Tatsumoto N, Arioka M, Yamada S, Takahashi-Yanaga F, Tokumoto M, Tsuruya K, Kitazono T, Sasaguri T., Inhibition of GSK-3β increases trabecular bone volume but not cortical bone volume in adenine-induced uremic mice with severe hyperparathyroidism., Physiol Rep, 2016.11.
15. Noma T, Takahashi-Yanaga F, Arioka M , Mori Y, Sasaguri T., Inhibition of GSK-3 reduces prostaglandin E2 production by decreasing the expression levels of COX-2 and mPGES-1 in monocyte/macrophage lineage cells., Biochem Pharmacol, 116, 120-129, 2016.09.
16. Mohamed R, Morimoto S, Ibrahim I, Zhan DY, Du CK, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T., GSK3β heterozygous knockout is cardioprotective in a knock-in mouse model of familial dilated cardiomyopathy., Am J Physiol Heart Circ Physiol, 310, 11, H1808-H1815, 2016.06.
17. Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T., Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo., J Pharmacol Sci, 127, 4, 446-455, 2015.04.
18. Nonaka M, Morimoto S, Murayama T, Kurebayashi N, Li L, Wang YY, Arioka M, Yoshihara T, Takahashi-Yanaga F, Sasaguri T., Stage-dependent benefits and risks of pimobendan in genetic dilated cardiomyopathy mice with progressive heart failure., Br J Pharmacol, 172, 9, 2369-2382, 2015.05.
19. Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Hirata M, Mori Y, Sasaguri T., Acceleration of bone regeneration by local application of lithium: Wnt signal-mediated osteoblastogenesis and Wnt signal-independent suppression of osteoclastogenesis., Biochem Pharmacol, 90, 4, 397-405, 2014.08.
20. Takahashi-Yanaga F, Yoshihara T, Jingushi K, Igawa K, Tomooka K, Watanabe Y, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Sasaguri T., DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice., Biochem Pharmacol, 89, 3, 340-348, 2014.06.
21. Kamide K, Asayama K, Katsuya T, Ohkubo T, Hirose T, Inoue R, Metoki H, Kikuya M, Obara T, Hanada H, Thijs L, Kuznetsova T, Noguchi Y,Sugimoto K, Ohishi M, Morimoto S, Nakahashi T, Takiuchi S, Ishimitsu T, Tsuchihashi T, Soma M, Higaki J, Matsuura H, Shinagawa T, Sasaguri T, Miki T, Takeda K, Shimamoto K, Ueno M, Hosomi N, Kato J, Komai N, Kojima S, Sase K, Miyata T, Tomoike H, Kawano Y, Ogihara T, Rakugi H, Staessen JA, Imai Y; GEANE study group; HOMED-BP study group, Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study., Pharmacogenomics, 14, 14, 1709-1721, 2013.11.
22. Arioka M, Takahashi-Yanaga F, Sasaki M, Yoshihara T, Morimoto S, Takashima A, Mori Y, Sasaguri T., Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in GSK-3β+/- mice., Biochem Biophys Res Commun, 440, 4, 677-682, 2013.11.
23. Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T,; The Comfort Investigators., Impact of antihypertensive medication adherence on blood pressure control in hypertension: the COMFORT study., QJM, 106, 10, 909-914, 2013.10.
24. Jingushi K, Nakamura T, Takahashi-Yanaga F, Matsuzaki E, Watanabe Y, Yoshihara T, Morimoto S, Sasaguri T., Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines, J Pharmacol Sci, 121, 2, 103-109, 2013.02.
25. Kajioka S, Takahashi-Yanaga F, Shahab N, Onimaru M, Matsuda M, Takahashi R, Asano H, Morita H, Morimoto S, Yonemitsu Y, Hayashi M, Seki N, Sasaguri T, Hirata M, Nakayama S, Naito S., Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction, Sci Rep, 2, 979, 2012.02.
26. Li L, Morimoto S, Take S, Zhan D-Y, Du, C-K, Wang, Y-Y, Fan X-L, Yoshihara T, Takahashi-Yanaga F, Katafuchi T, Sasaguri T., Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure, J Mol Cell Cardiol, 53, 6, 760-767, 2012.12.
27. Matsumura, K., Arima, H., Tominaga, M., Ohtsubo, T., Sasaguri, T., Fujii, K., Fukuhara, M., Uezono, K., Morinaga, Y., Ohta, Y., Otonari, T., Kawasaki, J., Kato, I., Tsuchihashi, T. for the COMFORT Investigators, Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?, Circ J, 76, 6, 1415-1422, 2012.06.
28. Jingushi, K., Takahashi-Yanaga, F., Yoshihara, T., Shiraishi, F., Watanabe, Y., Hirata, M., Morimoto, S., & Sasaguri, T., DIF-1 Inhibits the Wnt/β-catenin Signaling Pathway by Inhibiting TCF7L2 Expression in Colon Cancer Cell Lines., Biochem Pharmacol, 83, 1, 47-56, 2012.01.
29. Sakata, S., Yoshihara, T., Arima, H., Shiraishi, F., Oniki, H., Takahashi-Yanaga, F., Matsumura, K., & Sasaguri, T., Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial., BMJ Open, 2011.07.
30. Fan, X., Takahashi-Yanaga, F., Morimoto, S., Zhan, D.-Y., Igawa, K., Tomooka, K., & Sasaguri, T., Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited DCM mouse model., J. Pharmacol. Exp. Ther., 2011.07.
31. Sasaguri, T., Shiraishi, F., Yoshihara, T., Takahashi-Yanaga, F., & Morimoto, S., β1-adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects., J. Pharmacol. Sci., 115, 4, 490-499, 2011.04.
32. Miwa, Y., Tsuchihashi, T., Ohta, Y., Tominaga, M., Kawano, Y., Sasaguri, T., Ueno, M., & Matsuoka, H., Antiproteinuric effect of cilnidipine in hypertensive japanese treated with renin-angiotensin-system inhibitors - A multicenter, open, randomized trial using 24-hour urine collection., Clin. Exp. Hypertens., 32, 6, 400-405, 2010.12.
33. Yoshihara, T., Takahashi-Yanaga, F., Shiraishi, F., Morimoto, S., Watanabe, Y., Hirata, M., Hoka, S., & Sasaguri, T., Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/beta-catenin signaling pathway., Mol. Cancer, 9, 1, 245, 2010.07.
34. Tadano, N., Du C.-K., Yumoto, F., Morimoto, S., Ohta, M., Xie, M.-F., Nagata, K., Zhan, D.-Y., Lu, Q.-W., Miwa, Y., Takahashi-Yanaga, F., Tanokura, M., Ohtsuki, I., & Sasaguri, T., Biological actions of green tea catechins on cardiac troponin C., Br. J. Pharmacol., 161, 5, 1034-1043, 2010.05.
35. Wang, Y.-Y., Morimoto, S., Du, C.-K., Lu, Q.-W., Zhan, D.-Y., Tsutsumi, T., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. , Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy., Cardiovasc. Res., 2010.03.
36. Matsuda, T., Takahashi-Yanaga, F., Yoshihara, T., Maenaka, K., Watanabe, Y., Miwa, Y., Morimoto, S., Kubohara, Y., Hirata, M., & Sasaguri, T., Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity., J. Pharmacol. Sci., 112, 3, 320-326, 2009.03.
37. Ohmine, T., Miwa, Y., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., & Sasaguri, T., The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells., Hypertens Res, 32, 8, 690-699, 2009.08.
38. Zhan, D.-Y., Morimoto, S., Du, C.-K., Wang, Y.-Y., Lu, Q.-W., Tanaka, A., Ide, T., Miwa, Y., Takahashi-Yanaga, F., & Sasaguri, T. , Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation., Cardiovasc Res, 84, 1, 67-71, 2009.01.
39. Yao, H., Takashima, Y., Mori, T., Uchino, A., Hashimoto, M., Yuzuriha, T., Miwa, Y., & Sasaguri, T., Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study., Hypertens Res, 32, 7, 586-590, 2009.07.
40. Tadano, N., Morimoto, S., Takahashi-Yanaga, F., Miwa, Y., Ohtsuki, I., & Sasaguri, T., Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament., J. Pharmacol. Sci., 109(3), 456-458, 2009.06.
41. Tanaka, R., Miwa, Y., Mou, K., Tomikawa, M., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., Wake, N., & Sasaguri, T., Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. , Biochem. Biophys. Res. Commun., 378(4), 851-856, 2009.01.
42. Miwa, Y., Oda, H., Shiina, Y., Shikata, K., Tsushima, M., Nakano, S., Maruyama, T., Kyotani, S., Eguchi, N., Urade, Y., Takahashi-Yanaga, F., Morimoto, S., & Sasaguri, T., Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects., Hypertens Res., 31(10), 1931-1939, 2008.10.
43. Takahashi-Yanaga, F., Yoshihara, T., Jingushi, K., Miwa, Y., Morimoto, S., Hirata, M., & Sasaguri, T., Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells., Biochem. Biophys. Res. Commun., 377(4), 1185-1190, 2008.04.
44. Ohmine, T., Miwa, Y., Yao, H., Yuzuriha, T., Takashima, Y., Uchino, A., Takahashi-Yanaga, F., Morimoto, S., Maehara, Y., Sasaguri, T., Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects, Hypertens. Res., 31(1), 75-81, 2008.01.
45. Du, C.-K., Morimoto, S., Nishii, K., Minakami, R., Ohta, M., Tadano, N., Lu, Q.-W., Wang, Y.-Y., Zhan, D.-Y., Mochizuki, M., Kita, S., Miwa, Y., Takahashi-Yanaga, F., Iwamoto, T., Ohtsuki, I., Sasaguri, T., Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation, Circ. Res., 101(2), 185-194, 2007.07.