


Toshio Kukita | Last modified date:2020.07.06 |

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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/toshio-kukita
Reseacher Profiling Tool Kyushu University Pure
Phone
092-642-6300
Fax
092-642-6304
Academic Degree
Doctor of Dental Science (Kyushu University)
Country of degree conferring institution (Overseas)
No
Field of Specialization
Anatomy, Bone Cell Biology, Immunology, Oral Histology & Embryology
Total Priod of education and research career in the foreign country
02years02months
Outline Activities
Bone is a dynamic tissue in which continuous cycles of bone degradation (bone resorption) and bone formation occur at the surface of the bone. This biological process is known as Bone Remodeling. It is quite important to keep the balance between the amount of bone formation mediated by osteoblasts and that of bone resorption performed by osteoclasts in maintenance of healthy bone. Once we lose this balance, we suffer from the metabolic bone diseases, e.g. osteoporosis. Molecular mechanism of the bone remodeling is not fully understood. It is postulated that bone resorbing osteoclasts play a central role in Bone Remodeling. In other words, osteoclasts are required for the subsequent bone formation in the normal bone remodeling process. To know the detailed molecular mechanism of bone remodeling, we are focusing on searching unique cell surface molecules expressed on cell surface of osteoclasts and their precursors, which are involved in the regulatory process of bone remodeling. Furthermore, we are now focusing on the specific regulation of pathological bone destruction without affecting normal bone remodeling. For this purpose, we are extensively investigating the difference in the normal osteoclasts and pathologically activated osteoclasts (PAOC) in molecular level. It will be possible to regulate only the pathological bone destruction without affecting normal bone remodeling which is essential for keeping bone health.
Through these studies, it should be possible to regulate bone remodeling process in a highly specific manner. These studies provide abundant seeds creating novel medicine suitable for metabolic bone diseases and inflammatory bone destruction accompanying rheumatoid arthritis and periodontal disease.
The following are the list of studies currently performed in our laboratory.
1) Searching and identification of PAOC-specific cell surface molecules: Specific regulation of inflammatory bone destruction through PAPC-specific molecules.
2) Identification of cell surface molecule involved in membrane fusion among osteoclast precursors (one of the important steps in osteoclastogenesis): Regulation of osteoclastogenesis through this regulatory molecule.
3) Molecular basis of the coupling of osteoclasts and osteoblasts
4) Regulation of bone remodeling through osteoblast-specific cell surface molecules
5) Regulation of inflammatory bone destruction by mesenchymal stem cells
6) Regulation of bone metabolism through key molecules involved in the inert immunity
7) Regulation of bone remodeling by membrane tunneling nanotubes
8) Mechanism of bone metastasis of tumors
9) Regeneration of dentin: immunological approach
Through these studies, it should be possible to regulate bone remodeling process in a highly specific manner. These studies provide abundant seeds creating novel medicine suitable for metabolic bone diseases and inflammatory bone destruction accompanying rheumatoid arthritis and periodontal disease.
The following are the list of studies currently performed in our laboratory.
1) Searching and identification of PAOC-specific cell surface molecules: Specific regulation of inflammatory bone destruction through PAPC-specific molecules.
2) Identification of cell surface molecule involved in membrane fusion among osteoclast precursors (one of the important steps in osteoclastogenesis): Regulation of osteoclastogenesis through this regulatory molecule.
3) Molecular basis of the coupling of osteoclasts and osteoblasts
4) Regulation of bone remodeling through osteoblast-specific cell surface molecules
5) Regulation of inflammatory bone destruction by mesenchymal stem cells
6) Regulation of bone metabolism through key molecules involved in the inert immunity
7) Regulation of bone remodeling by membrane tunneling nanotubes
8) Mechanism of bone metastasis of tumors
9) Regeneration of dentin: immunological approach
Research
Research Interests
Membership in Academic Society
- Specific & Powerful Regulation of Pathological Bone Destruction which does not affect normal bone remodeling: Development of a Novel Strategy of the Next Generation
keyword : pathological bone destruction, osteoclast, bone marrow, stem cell
2012.04~2021.03. - 1)Molecular Mechanism of Osteoclast Differentiation and Activation 2)Specific Regulation of Inflammatory Bone Destruction 3)Mechanism of Hard Tissue Regeneration
keyword : osteoclast. bone remodeling, hard tissue regeneration, regulation, tissue stem cell, monoclonal antibody
2008.04~2013.03.
Reports
Papers
Presentations
- International Bone and Minaral Society (IBMS)
- Molecular Biology Society of Japan
- Japanese Society of Bone and Mineral Metabolism
- Japanese Association for Oral Biology
- Japanese Association of Anatomists
Educational
Educational Activities
Oral Histology (Lecture): I am teaching students of Faculty of Dental Science in Kyushu University details about histology of tooth tissues and periodontal tissues involving enamel, dentin, cementum, pulp, gingiva and periodontal ligament as well as the histology of oral mucous membrane and salivary gland. I always doing efforts to explain histology from the aspect of developmental biology, in other words, I explain how each tissue structures seen in oral tissues were formed during morphogenesis of the human body.
Oral Cell Biology (Lecture): I introduce research world to students of Faculty of Dental Science in Kyushu University. After showing the overview of cell growth and differentiation as well as recent development in regenerative medicine, I explain bone metabolism especially about osteoclast cell biology.
Practice in histology: I teach students of Faculty of Dental Science in Kyushu University about histology of the digestive tissues involving esophagus, stomach, small intestine, large intestine, liver and pancreas.
Basic Biology II(Lecture): As the lecture of Basic Biology II to students of Kyushu University, I pick up some topics in the current life science (regenerative medicine, cancer specific medicine et al.) and explain each topic with illustrating basic knowledges in biology.
Oral Histology (Kyushu Dental College): I teach overview of bone metabolism to students of Kyushu Dental College.
Since 1999 President of Ice Hockey Club of Kyushu University
Other Educational Activities
Oral Cell Biology (Lecture): I introduce research world to students of Faculty of Dental Science in Kyushu University. After showing the overview of cell growth and differentiation as well as recent development in regenerative medicine, I explain bone metabolism especially about osteoclast cell biology.
Practice in histology: I teach students of Faculty of Dental Science in Kyushu University about histology of the digestive tissues involving esophagus, stomach, small intestine, large intestine, liver and pancreas.
Basic Biology II(Lecture): As the lecture of Basic Biology II to students of Kyushu University, I pick up some topics in the current life science (regenerative medicine, cancer specific medicine et al.) and explain each topic with illustrating basic knowledges in biology.
Oral Histology (Kyushu Dental College): I teach overview of bone metabolism to students of Kyushu Dental College.
Since 1999 President of Ice Hockey Club of Kyushu University
- 2009.11, Kyudai Festival Special Lecture: As a special event in the festival of Kyushu University, based on the selection by students in Ito campus, I was invited by students as a special speaker of the Special Lecture entitled "Bone and Regenerative Medicine: Tooth, Bone and Regenerative Medicine"..
- 2002.11.
Social
Professional and Outreach Activities
2003-: Collaborative research with Sankyo Co.Ltd. on bone metanolism.
2002: Lecture on bone metabolism and regenerative medicine to high school students
of Sainan Gakuin High School, Fukuoka. (Delivery Service of University Lectures programmed by Sainan Gakuin High School)
2001: Collaborative research with Teijin Co.Ltd. (Dr. Ishizuka) on vitamin D antagonists.
2000-: Collaborative research with Kumamoto Flour Milling Company Co.Ltd. on food materials promoting bone health.
1900-1903: Collaborative research with Idemitsu Kosan Co.Ltd. on development of bone metabolism..
2002: Lecture on bone metabolism and regenerative medicine to high school students
of Sainan Gakuin High School, Fukuoka. (Delivery Service of University Lectures programmed by Sainan Gakuin High School)
2001: Collaborative research with Teijin Co.Ltd. (Dr. Ishizuka) on vitamin D antagonists.
2000-: Collaborative research with Kumamoto Flour Milling Company Co.Ltd. on food materials promoting bone health.
1900-1903: Collaborative research with Idemitsu Kosan Co.Ltd. on development of bone metabolism..


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