Kyushu University Academic Staff Educational and Research Activities Database
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Takayoshi Yamaza Last modified date:2022.06.24

Professor / Oral Biological Sciences
Department of Dental Science
Faculty of Dental Science


Graduate School
Undergraduate School
Other Organization
Other


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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/takayoshi-yamaza
 Reseacher Profiling Tool Kyushu University Pure
Phone
092-642-6305
Fax
092-642-6304
Academic Degree
PhD
Country of degree conferring institution (Overseas)
No
Field of Specialization
Anatomy, Oral Anatomy, Histology,Oral Histology, Embryology, Stem Cell Biology
Total Priod of education and research career in the foreign country
03years08months
Outline Activities
1. Human stem cell-based translational research in regenerative medicine and dental medicine
2. Origin, phenotypes and kinetics of stem cells
3. Function of stem cells in bone and mineral metabolism and osteoimmunology
4. Lecture and Practice of Anatomy for dental school students
5. Lecture and Practice of Oral Anatomy for dental school students
6. Lecture and Practice of Tooth Anatomy for dental school students
7. Lecture of Human Development for dental school students
8. Lecture and Practice of Oral Histology for dental school students
9. Early exposure to undergraduate dental students
10. Research exposure to undergraduate dental students
11. Scientific instruction to graduate students
12. Scientific instruction to undergraduate students
Research
Research Interests
  • Origin, Characterization and Kinetics of Stem Cells
    keyword : Stem Cells, Origin, Characterization, Kinetics
    2009.04Relationship and interaction of origin, characterization and knetics of mesencymal stem cells in bone marrow and dental tissue (dental pulp and periodontal ligamnet etc.) with the niche..
  • Translational Research of HumanStem Cells in Regenerative Medicine
    keyword : Regeneration in Dental Medicine, Stem Cells in Translational Research
    2009.04Translational research in Dental Medical Regenerative Medicine applied by mesenchymalstem cells derived from bone marrow and dental tissues.
  • Functional Characterization of Stem Cells in Bone Metabolism and Osteoimmunology
    keyword : Bone Metabolism, Osteoimmunology, Mesenchymal Stem Cells
    2009.04Interaction of mesenchymal stem cells with bone metabolism and osteoimmunology.
Academic Activities
Books
1. Soichiro Sonoda, Erika Tomoda, Yosuke Tanaka, Takayoshi Yamaza, Properties and possibilities of human dental pulp-derived stem cells. , SciMedCentral, 2(2):1012, 2015.07.
2. Sonoyama W, Yamaza T, Gronthos S, Shi S. , Chaptor 8. Multipotent Stem Cells in Dental Pulp. In Culture of Human Stem Cells (Ed Stacey GN, Freshney RI, Auerbach JM) , Wiley, pp. 187-206. , 2007.07.
Reports
1. Sonoda, S. & Yamaza, T., A New Target of Dental Pulp-Derived Stem Cell-Based Therapy on Recipient Bone Marrow Niche in Systemic Lupus Erythematosus, International journal of molecular sciences., 23, 7, 3479., 2022.04.
2. Yamaza T, Akiyama K, Shi S., Is aspirin treatment an appropriate intervention for osteoporosis? , 3(6):499-502., 2008.12.
3. Miura M, Miura Y, Sonoyama W, Yamaza T, Gronthos S, Shi S. , Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region. , Oral Diseases, 12(6):514-522., 2006.11.
4. Goto T, Yamaza T, Tanaka T. , Cathepsins in the osteoclast., 551-558, 52(6):551-558. , 2003.12.
5. T. Goto, M. A. Kido, T. Yamaza, and T. Tanaka., Substance P and substance P receptors in bone and gingival tissues, Medical Electron Microscopy, 34(2):77-85., 2001.06.
Papers
1. Dental pulp stem cells as a therapy for congenital entero-neuropathy Yoshimaru, K., Yamaza, T., Kajioka, S., Sonoda, S., Yanagi, Y., Matsuura, T., Yoshizumi, J., Oda, Y., Iwata, N., Takai, C., Nakayama, S. & Taguchi, T., Dental pulp stem cells as a therapy for congenital entero-neuropathy, Scientific Reports, 12, 1, 6990., 2022.12.
2. Sonoda, Soichiro; Yoshimaru, Koichiro; Yamaza, Haruyoshi; Yuniartha, Ratih; Matsuura, Toshiharu; Yamauchi-Tomoda, Erika; Murata, Sara; Nishida, Kento; Oda, Yoshinao; Ohga, Shouichi; Tajiri, Tasturo; Taguchi, Tomoaki; Yamaza, Takayoshi, Biliary atresia-specific deciduous pulp stem cells feature biliary deficiency, STEM CELL RESEARCH & THERAPY, 10.1186/s13287-021-02652-8, 12, 1, 2021.11.
3. Yuniartha, R., Yamaza, T., Sonoda, S., Yoshimaru, K., Matsuura, T., Yamaza, H., Oda, Y., Ohga, S. & Taguchi, T.,, Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells, Stem Cell Research and Therapy. , 12, 1, 57, 2021.01.
4. Soichiro Sonoda, Sara Murata, Hiroki Kato, Fouad Zakaria, Yukari Kyumoto-Nakamura, Norihisa Uehara, Haruyoshi Yamaza, Toshio Kukita, Takayoshi Yamaza, Targeting of Deciduous Tooth Pulp Stem Cell-Derived Extracellular Vesicles on Telomerase-Mediated Stem Cell Niche and Immune Regulation in Systemic Lupus Erythematosus, The Journal of Immunology, doi: 10.4049/jimmunol.2001312, In press, 2020.07, Systemic transplantation of stem cells from human exfoliated deciduous teeth (SHED) is used to treat systemic lupus erythematosus (SLE)-like disorders in MRL/lpr mice. However, the mechanisms underlying the SHED-based therapy remain unclear. In this study, we hypothesized that trophic factors within SHED-releasing extracellular vesicles (SHED-EVs) ameliorate the SLE-like phenotypes in MRL/lpr mice. SHED-EVs were isolated from the culture supernatant of SHED. SHED-EVs were treated with or without RNase and systemically administered to MRL/lpr mice. Subsequently, recipient bone marrow mesenchymal stem cells (BMMSCs) isolated from SHED-EV-administered MRL/lpr mice were examined for the in vitro and in vivo activity of hematopoietic niche formation and immunoregulation. Furthermore, the recipient BMMSCs were secondarily transplanted into MRL/lpr mice. The systemic SHED-EV infusion ameliorated the SLE-like phenotypes in MRL/lpr mice and improved the functions of recipient BMMSCs by rescuing Tert mRNA-associated telomerase activity, hematopoietic niche formation, and immunoregulation. The secondary transplantation of recipient BMMSCs recovered the immune condition and renal functions of MRL/lpr mice. The RNase treatment depleted RNAs, such as microRNAs, within SHED-EVs, and the RNA-depleted SHED-EVs attenuated the benefits of SHED-EVs in MRL/lpr mice. Collectively, our findings suggest that SHED-secreted RNAs, such as microRNAs, play a crucial role in treating SLE by targeting the telomerase activity of recipient BMMSCs..
5. Ratih Yuniarthe, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi, Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells, Stem Cell Research and Therapy, 10.1186/s13287-020-02113-8., 12, 1, 2020.01, Background: Stem cells from human exfoliated deciduous teeth (SHED) have been reported to show the in vivo and in vitro hepatic differentiation, SHED-Heps; however, the cholangiogenic potency of SHED-Heps remains unclear. Here, we hypothesized that SHED-Heps contribute to the regeneration of intrahepatic bile duct system in chronic fibrotic liver.

Methods: SHED were induced into SHED-Heps under cytokine stimulation. SHED-Heps were intrasplenically transplanted into chronically CCl4-treated liver fibrosis model mice, followed by the analysis of donor integration and hepatobiliary metabolism in vivo. Immunohistochemical assay was examined for the regeneration of intrahepatic bile duct system in the recipient liver. Furthermore, SHED-Heps were induced under the stimulation of tumor necrosis factor alpha (TNFA).

Results: The intrasplenic transplantation of SHED-Heps into CCl4-treated mice showed that donor SHED-Heps behaved as human hepatocyte paraffin 1- and human albumin-expressing hepatocyte-like cells in situ and ameliorated CCl4-induced liver fibrosis. Of interest, the integrated SHED-Heps not only expressed biliary canaliculi ATP-binding cassette transporters including ABCB1, ABCB11, and ABCC2, but also recruited human keratin 19- (KRT19-) and KRT17-positive cells, which are considered donor-derived cholangiocytes, regenerating the intrahepatic bile duct system in the recipient liver. Furthermore, the stimulation of TNFA induced SHED-Heps into KRT7- and SRY-box 9-positive cells.

Conclusions: Collectively, our findings demonstrate that infused SHED-Heps showed cholangiogenic ability under the stimulation of TNFA in CCl4-damaged livers, resulting in the regeneration of biliary canaliculi and interlobular bile ducts in chronic fibrotic liver. Thus, the present findings suggest that SHED-Heps may be a novel source for the treatment of cholangiopathy..
6. Soichiro Sonoda1, Sara Murata, Kento Nishida, Hiroki Kato, Norihisa Uehara, Yukari N. Kyumoto, Haruyoshi Yamaza, Ichiro Takahashi, Toshio Kukita, Takayoshi Yamaza, Extracellular vesicles from deciduous pulp stem cells recover bone loss by regulating telomerase activity in an osteoporosis mouse model, Stem cell research and therapy, 10.1186/s13287-020-01630-w., 11, 1, 296, 2020.07.
Presentations
1. Ma Lan, Yamaza Haruyoshi, Akiyama Kentaro, Song Guangtai, Kukita Toshio, Shi Songtao, Nonaka Kazuaki, Yamaza Takayoshi, Long Term Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Utilize for a Feasible Stem Cell Resource for Regenerative Medicine
, Gordon Reserch Conference, Biomaterials and tissue engineering, 2012.07.
Membership in Academic Society
  • Japanese Association of Denal Research
  • International association of Dental research
Awards
  • Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases.
    F Feng, K Akiyama, Y Liu, T Yamaza, T-M Wang, J-H Chen, BB Wang, G T-J Huang, S Wang, S Shi.
Educational
Educational Activities
1. Lecture and Practice of Human Anatomy to undergraduate dental students
2. Lecture and Practice of Human Oral Anatomy to undergraduate dental students
3. Lecture and Practice of Human Tooth Anatomy to undergraduate dental students
4. Lecture of Human Development to undergraduate dental students
5. Lecture and Practice of Human Oral Histology to undergraduate dental students
6. Early exposure to undergraduate dental students
7. Research exposure to undergraduate dental students
8. Scientific instruction to graduate students
9. Scientific instruction to undergraduate students
Other Educational Activities
  • 2010.10.