Kyushu University Academic Staff Educational and Research Activities Database
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Takayoshi Yamaza Last modified date:2019.12.07

Associate Professor / Oral Biological Sciences
Department of Dental Science
Faculty of Dental Science

Graduate School
Undergraduate School
Other Organization

Academic Degree
Field of Specialization
Anatomy, Stem Cell Biology
Outline Activities
1. Human mesenchymal stem cell-based translational research in regenerative medicine and dental medicine
2. Origin, phenotypes and kinetics of mesenchymal stem cells
3. Function of mesenchymal stem cells in bone and mineral metabolism and osteoimmunology
4. Mechanism of osteclastic bone resorption
5. Function of junctional epithelium in gingiva
6. Lecture of Anatomy for dental school students
7. Practical Lecture of Anatomy for dental school students
Research Interests
  • Functional Characterization of Mesenchymal Stem Cells in Bone Metabolism and Osteoimmunology
    keyword : Bone Metabolism, Osteoimmunology, Mesenchymal Stem Cells
    2009.04Interaction of mesenchymal stem cells with bone metabolism and osteoimmunology.
  • Origin, Characterization and Kinetics of Mesenchymal Stem Cells
    keyword : Mesenchymal Stem Cells, Origin, Characterization, Kinetics
    2009.04Relationship and interaction of origin, characterization and knetics of mesencymal stem cells in bone marrow and dental tissue (dental pulp and periodontal ligamnet etc.) with the niche..
  • Translational Research of Human Mesenchymal Stem Cells in Regenerative Medicine
    keyword : Regeneration in Dental Medicine, Stem Cells in Translational Research
    2009.04Translational research in Dental Medical Regenerative Medicine applied by mesenchymalstem cells derived from bone marrow and dental tissues.
Academic Activities
1. Soichiro Sonoda, Erika Tomoda, Yosuke Tanaka, Takayoshi Yamaza, Properties and possibilities of human dental pulp-derived stem cells. , SciMedCentral, 2(2):1012, 2015.07.
2. Sonoyama W, Yamaza T, Gronthos S, Shi S. , Chaptor 8. Multipotent Stem Cells in Dental Pulp. In Culture of Human Stem Cells (Ed Stacey GN, Freshney RI, Auerbach JM) , Wiley, pp. 187-206. , 2007.07.
1. Yamaza T, Akiyama K, Shi S., Is aspirin treatment an appropriate intervention for osteoporosis? , 3(6):499-502., 2008.12.
2. Miura M, Miura Y, Sonoyama W, Yamaza T, Gronthos S, Shi S. , Bone marrow-derived mesenchymal stem cells for regenerative medicine in craniofacial region. , Oral Diseases, 12(6):514-522., 2006.11.
3. Goto T, Yamaza T, Tanaka T. , Cathepsins in the osteoclast., 551-558, 52(6):551-558. , 2003.12.
4. T. Goto, M. A. Kido, T. Yamaza, and T. Tanaka., Substance P and substance P receptors in bone and gingival tissues, Medical Electron Microscopy, 34(2):77-85., 2001.06.
1. Tanaka Y, Sonoda S, Yamaza H, Murata S, Nishida K, Kyumoto-Nakamura Y, Uehara N, Nonaka K, Kukita T, Yamaza T., Acetylsalicylic Acid Treatment and Suppressive Regulation of AKT Accelerate Odontogenic Differentiation of Stem Cells from the Apical Papilla, Journal of Endodontology, 45(5):591-598, 2019.05.
2. Taguchi T, Yanagi Y, Yoshimaru K, Zhang XY, Matsuura T, Nakayama K, Kobayashi E, Yamaza H, Nonaka K, Ohga S, Yamaza T., Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery., Surgery Today, 49(4):316-322, 2019.04.
3. Fujiyoshi J, Yamaza H, Sonoda S, Yuniartha R, Ihara K, Nonaka K, Taguchi T, Ohga S, Yamaza T., Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson's disease., Scientific Reports, 9(1):1535, 2019.02.
4. Yamaza H, Sonoda S, Nonaka K, Kukita T, Yamaza T., Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth., Stem Cell Res Ther, 9(1):303, 2018.11.
5. Tanaka Y, Sonoda S, Yamaza H, Murata S, Nishida K, Hama S, Kyumoto-Nakamura Y, Uehara N, Nonaka K, Kukita T, Yamaza T., Suppression of AKT-mTOR signal pathway enhances osteogenic/dentinogenic capacity of stem cells from apical papilla., Stem Cell Res Ther, 9(1):334, 2018.11.
6. Soichiro Sonoda, Mei YF, Atsuta I, Danjo A, Haruyoshi Yamaza, Sion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza, Exogenous nitric oxide stimulates the odontogenic differentiation of rat dental pulp stem cells., Scientific Reports, 8:3419., 2018.02.
7. Haruyoshi Yamaza, Erika Tomoda, Soichiro Sonoda, Kazuaki Nonaka, Toshio Kukita, Takayoshi Yamaza, Bilirubin reversibly affects cell death and odontogenic capacity in stem cells from human exfoliated deciduous teeth., Oral Diseases, 2018.01.
8. Ma L, Aijima R, Hoshino Y, Yamaza H, Tomoda E, Tanaka Y, Sonoda S, Song G, Zhao W, Nonaka K, Shi S, Yamaza T. , Transplantation of mesenchymal stem cells ameliorates secondary osteoporosis through interleukin-17-impaired functions of recipient bone marrow mesenchymal stem cells in MRL/lpr mice., PLoS One, 6:104, 2015.04.
9. Kondo Ryosuke, ATSUTA IKIRU, AYUKAWA Yasunori, Yamaza Takayoshi, Yuri Matsuura, Furuhashi A, Yoshihiro Tsukiyama, koyano kiyoshi, Therapeutic interaction of systemically-administered mesenchymal stem cells with peri-implant mucosa., PLoS ONE, 9(3): e90681., 2014.03.
10. Chen C, Akiyama K, Yamaza T, You YO, Xu X, Li B. Gronthos S, Jin Y, Zao Y, Shi S. , Telomerase Governs Immunomodulatory Properties of Mesenchymal Stem Cells by Regulating Fas Ligand Expression., EMBO Molecular Medicine, 2014.01.
11. Qin H, Qu C, Yamaza T,Yang R, Lin X, Duan XY, Akiyama K, Liu Y, Zhang Q, Chen C, Chen Y, Qi HH, Feng XH, Le AD, Shi S. , Ossifying Fibroma Tumor Stem Cells Are Maintained by Epigenetic Regulation of a TSP1/TGF-β/SMAD3 Autocrine Loop., Cell Stem Cell, 13(5):577-589., 2013.11.
12. Yusuke Makino, Haruyoshi Yamaza, Kentaro Akiyama, Yoshihiro Hoshino, Kazuaki Nonaka, Yoshihiro Terada, Toshio Kukita, Songtao Shi, Takayoshi Yamaza, Immune therapeutic potential of stem cells from human supernumerary teeth., J Dental Research, 92(7):609-615, 2013.07.
13. Ma L, Makino Y, Yamaza H, Akiyama K, Hoshino Y, Song G, Kukita T, Nonaka K, Shi S, Yamaza T., Cryopreserved dental pulp tissues of exfoliated deciduous teeth is a feasible stem cell resource for regenerative medicine., PLoS One, 7(12):e51777, 2012.12.
14. Akiyama A, You YO, Yamaza T, Chen C, Tang L,Jin Y, Chen XD, Gronthos S, Shi S., Characterization of bone marrow derived mesenchymal stem cells in suspension, Stem Cell Research and Therapy, 3: 40, 2012.10.
15. Wang D, Akiyama K, Zhang H, Yamaza T, Li X, Feng X, Wang H, Hua B, Liu B, Xu HJ, Chen WJ, Shi S and Sun L., Double allogenic mesenchymal stem cells transplantations could not enhance therapeutic effect compared with single transplantation in systemic lupus erythematosus. , Clinical and Developmental Immunology, 2012.07.
16. Akiyama K, Chen C, Wang D, Xu X, Qu C, Yamaza T, Cai T, Chen W, Sun L, Shi S. , Mesenchymal-stem-cell-induced immunoregulatyion involves Fas-ligand-/Fas-mediated T cell apoptosis. , Cell Stem Cell, 10:544-555., 2012.04.
17. Yamaza T, Ren G, Akiyama K, Chen C, Shi Y, Shi S. , Mouse Mandible Contains Distinctive Mesenchymal Stem Cells. , Journal of Dental Research, 90(3):317-324, 2011.03.
18. Parsa S, Kuremoto K, Seidel K, Tabatabai R, MacKenzie B, Yamaza T, Akiyama K, Branch J, Koh CJ, Al Alam D, Klein, OD, Bellusci S., Signaling by FGFR2b controls the regenerative capacity of adult mouse incisors., Development, 137(22):3743-3752., 2010.11.
19. Alongi, DJ, Yamaza T, Song Y, Fouad AF, Romberg EE, Shi S, Tuan RS, Huang GT. , Stem/progenitor cells from inflamed human dental pulp retain tissue regeneration potential., Regenerative Medicine, 5(4):617-631., 2010.05.
20. Kikuiri T, Kim I, Yamaza T, Akiyama K, Zhang Q, Li Y, Chen C, Chen W, Wang S, Le AD, Shi S., Cell-based immunotherapy with mesenchymal stem cells cures bisphosphonate-related osteonerosis of the jaw-like disease in mice., Journal of Bone and Mineral Research, 25(7):1668-1679., 2010.05.
21. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, Bringas Jr. P, Nonaka K, Chai Y., TGF-β mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue–tissue interactions during tongue morphogenesis., Developmental Biology, 341(1):186-195., 2010.05.
22. Yamaza T, Akiyama K, Chen C, Liu Y, Shi Y, Gronthos S, Wang S, Shi S. , Immunomodulatory properties of stem cells from human exfoliated deciduous teeth. , Stem Cell Research and Therapy, 1:5, 2010.04.
23. Huang G, Yamaza T, Shea LD, Djouad F, Kuhn NZ, Tuan R, Shi S., Stem/progenitor Cell-Mediated De Novo Regeneration of Dental Pulp with Newly Deposited Continuous Layer of Dentin in an In Vivo Model., Tissue Engineering Part A. , 16(2):605-615., 2010.02.
24. Feng F, Akiyama K, Liu Y, Yamaza T, Wang TM, Chen JH, Wang BB, Huang G, Wang S, Shi S. , Utility of PDL Progenitors for in vivo Tissue Regeneration: A Report of 3 Cases. , Oral Diseases, 16, 20-28, 16(1):20-28., 2010.01.
25. Zhang Q, Yamaza T, Kelly AP, Shi S, Wang S, Brown J, Wang L, French SW, Shi S, Le AD., Tumor-like stem cells derived from human keloid are governed by the inflammatory niche driven by IL-17/IL-6 axis. , PLoS One, 4(11):e7798.
, 2009.11.
26. Fan Z, Yamaza T, Lee JS, Wang S, Shi S, Wang CY. , BCOR regulates mesenchymal stem cell function by epigenetic mechanisms: a case study of a rare human genetic disorder OFCD. , Nature Cell Biology, 11(8):1002-1009., 2009.08.
27. Sun L, Akiyama K, Zhang H, Yamaza T, Hou Y, Zhao S, Xu T, Le A, Shi S. , Mesenchymal stem cell transplantation reserves multi-organ dysfunction in systemic lupus erythematousus mice and human. , Stem Cells, 27(6):1421-1432., 2009.06.
28. Chung IH, Yamaza T, Zhao H, Choung PH, Shi S, Chai Y. , Stem Cell Property of Post-Migratory Cranial Neural Crest Cells and Their Utility in Alveolar Bone Regeneration and Tooth Development. , Stem Cells, 27(4):866-877., 2009.04.
29. Yamaza T, Miura Y, Akiyama K, Bi Y, Sonoyama W, Gronthos S, Chen W, Le A, Shi S. , Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice. , Blood, 113(11):2595-2604., 2009.03.
30. Yamaza T, Kido MA, Wang B, Danjo A, Shimohira D, Murata N, Yoshinari M, Tanaka T., Distribution of substance P and neurokinin-1 receptors in the peri-implant epithelium around titanium dental implants in rats. , Cell and Tissue Research, 335(2):407-415., 2009.02.
31. Yamaza T, Miura Y, Bi Y, Liu Y, Akiyama K, Sonoyama W, Patel V, Gutkind S, Young M, Gronthos S, Le A, Wang CY, Chen WJ, Shi S. , Pharmacologic Stem Cell Based Intervention as a New Approach to Osteoporosis Treatment in Rodents. , PLoS ONE, 3(7):e2615., 2008.07.
32. Seo BM, Sonoyama W, Yamaza T, Coppe C, Kikuiri T, Akiyama K, Lee JS, Shi S. , SHED Repair Critical-Size Calvarial Defects in Mice. , Oral Diseases, 14(5):428–434., 2008.07.
33. Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, Huang GT. , Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. , Journal of Endodontics, 34(2):166-171., 2008.02.
34. Danjo A, Yamaza T, Kido MA, Shimohira D, Tsukuba T, Kagiya T, Yamashita Y, Nishijima K, Masuko S, Goto M, Tanaka T. , Cystatin C stimulates the differentiation of mouse osteoblastic cells and bone formation. , Biochemical and Biophysical Research Communication, 360(1):199-204., 2007.08.
35. Sonoyama W, Seo BM, Yamaza T, and Shi S. , Human Hertwig's Epithelial Root Sheath Cells Play Crucial Roles in Cementum Formation. , Journal of Dental Research, 86(7):594-599., 2007.07.
36. Fang D, Seo BM, Liu Y, Sonoyama W, Yamaza T, Zhang C, Wang S, Shi S. , Transplantation of Mesenchymal Stem Cells is an Optimal Approach for Plastic Surgery. , Stem Cells, 25(4):1021-1028., 2007.04.
37. Mei YF, Yamaza T, Atsuta I, Danjo A, Yamashita Y, Kido MA, Goto M, Akamine A, Tanaka T. , Sequential expression of endothelial nitric oxide synthase, inducible nitric oxide synthase, and nitrotyrosine in odontoblasts and pulp cells during dentin repair after tooth preparation in rat molars. , Cell and Tissue Research, 328(1):117-127., 2007.04.
38. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo B-M, Zhang C, Liu H, Gronthos S, Wang C-Y, Wang S, and Shi S. , Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. , PLoS ONE, 1:e79., 2006.12.
39. Atsuta I, Yamaza T, Yoshinari M, Goto T, Kido MA, Kagiya T, Mino S, Shimono M, Tanaka T. , Ultrastructural localization of laminin-5 (gamma2 chain) in the rat peri-implant oral mucosa around a titanium-dental implant by immuno-electron microscopy.. , Biomaterials, 10.1016/j.biomaterials.2005.03.046, 26, 32, 6280-6287, 26(32):6280-6287., 2005.11.
40. Atsuta I, Yamaza T, Yoshinari M, Mino S, Goto T, Kido MA, Terada Y, Tanaka T., Changes in the distribution of laminin-5 during peri-implant epithelium formation after immediate titanium implantation in rats. , Biomaterials, 10.1016/j.biomaterials.2004.05.033, 26, 14, 1751-1760, 26(14):1751-1760. , 2005.05.
41. Yamaza T, Mino S, Atsuta I, Danjo A, Kagiya T, Nishijima K, Zang JQ, Kido MA, Tanaka T. , Localization of the Endogenous Cysteine Proteinase Inhibitor, Cystatin C, and the Cysteine Proteinase, Cathepsin B, to the Junctional Epithelium in Rat Gingiva. , Acta Histochemica et Cytochemica, 10.1267/ahc.38.121, 38, 2, 121-129, 38(2):121-129., 2005.03.
42. Hirata M, Yamaza T, Mei YF, Akamine A. , Expression of osteocalcin and Jun D in the early period during reactionary dentin formation after tooth preparation in rat molars., Cell and Tissue Research, 10.1007/s00441-004-1035-y, 319, 3, 455-465, 319(3):455-465., 2005.03.
43. Kajiwara H, Yamaza T, Yoshinari M, Goto T, Iyama S, Atsuta I, Kido MA, Tanaka T. , The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats., Biomaterials, 10.1016/j.biomaterials.2004.02.072, 26, 6, 581-587, 26(6):581-587. , 2005.02.
44. Yamaza T, Masuda KF, Atsuta I, Nishijima K, Kido MA, Tanaka T., Oxidative stress-induced DNA damage in the synovial cells of the temporomandibular joint in the rat. , Journal of Dental Research, 83, 8, 619-624, 83(8):619-624., 2004.08.
45. Yamaza T, Masuda KF, Tsukiyama Y, Nishijima K, Murakami R, Kido MA, Koyano K, and Tanaka T., NF-kB Activation and iNOS Expression in the Synovial Membrane of Rat Temporomandibular Joints after Induced Synovitis, Journal of Dental Research, 82, 3, 183-188, 82(3):183-188., 2003.03.
46. Ikeda H, Shiraiwa M, Yamaza T, Yoshinari M, Kido MA, Ayukawa Y, Inoue T, Koyano K, Tanaka T. , Difference in the penetration of horseradish peroxidase tracer as a foreign substance into the peri-implant epithelium or junctional epithelium of rat gingivae., Clinical Oral Implants Research, 13(3):243-251., 2002.06.
47. Masuda KF, Yamaza T, Tsukiyama Y, Murakami R, Nishijima K, Kido MA, Koyano K, Tanaka T. , Distribution of Inducible Nitric Oxide Synthase, Interleukin-1b and Interleukin-1 Receptor in the Temporomandibular Joint of Normal Rats., Acta Histochemica et Cytochemica, 10.1267/ahc.35.11, 35, 1, 11-21, 35(1):11-21., 2002.01.
48. Yamaza T, Tsuji Y, Goto T, Kido MA, Nishijima K, Moroi R, Akamine A, Tanaka T. , Comparison in localization between cystatin C and cathepsin K in osteoclasts and other cells in mouse tibia epiphysis by immunolight and immunoelectron microscopy., Bone, 10.1016/S8756-3282(01)00466-5, 29, 1, 42-53, 29(1):42-53., 2001.07.
49. Tsuji Y, Yamaza T, Kido MA, Goto T, Nakata S, Akamine A, Nakasima A, Tanaka T. , Expression of cathepsin K mRNA and protein in odontoblasts after experimental tooth movement in the mouse maxilla by in situ hybridization and immunoelectron microscopy., Cell and Tissue Research, 303, 3, 359-369, 303(3):359-369., 2001.03.
50. Goto T, Yamaza T, Kido MA, Takana T. , Substance P activates osteoclast formation and osteoclastic bone resorption through the neurokinin-1 receptor., Acta Histochemica et Cytochemica, 10.1267/ahc.34.31, 34, 1, 31-38, 34(1):31-38., 2001.02.
51. Ikeda H, Yamaza T, Yoshinari M, Ohsaki Y, Ayukawa Y, Kido MA, Inoue T, Shimono M, Koyano K, Tanaka T. , Ultrastructual and immunoelectron microscopic studies of the peri-implant epithelium-implant (Ti-6Al-4V) interface of rat maxilla., Journal of Periodontology, 10.1902/jop.2000.71.6.961, 71, 6, 961-973, 71(6):961-973., 2000.06.
52. Kido MA, Yamaza T, Goto T, Tanaka T. , Immunocytochemical localization of substance P neurokinin-1 receptors in rat gingival tissue., Cell and Tissue Research, 10.1007/s004410051349, 297, 2, 213-222, 297(2):213-222., 1999.08.
53. Yamaza T, Goto T, Kamiya T, Kobayashi Y, Sakai H, Tanaka T. , Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur., Bone, 10.1016/S8756-3282(98)00138-0, 23, 6, 499-509, 23(6):499-509, 1998.12.
54. Goto T, Yamaza T, Kido MA, Tanaka T. , Light- and electron-microcopic study of thedistribution of axons containing substance P and the localization of neurokinin-1 receptor in bone., Cell and Tissue Research, 10.1007/s004410051100, 293, 1, 87-93, 293(1):87-93., 1998.07.
55. Yamaza T, Kido MA, Kiyoshima T, Nishimura Y, Himeno M, Tanaka T., A fluid-phase endocytotic capacity and intracellular degradation of a foreign protein (horseradish peroxidase) by lysosomal cystein proteinases in the rat junctional epithelium., Journal of Periodontal Research, 10.1111/j.1600-0765.1997.tb00575.x, 32, 8, 651-660, 32(8):651-660., 1997.11.
56. Moroi R, Yamaza T, Nishiura T, Nishimura Y, Terada Y, Abe K, Himeno M, Tanaka T., Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo., Archives of Oral Biology, 40(4):931-940., 1997.04.
57. Moroi R, Yamaza T, Ayukawa Y, Kiyoshima T, Ohsaki Y, Nishimura Y, Terada Y, Himeno M, Tanaka T, Changes in the immunocytochemical localization of cathepsin L and type I collagen in rat osteoclasts treated with E-64., Acta Histochemica et Cytochemica, 28, 6, 523-531, 28(6):523-531., 1995.12.
1. Ma Lan, Yamaza Haruyoshi, Akiyama Kentaro, Song Guangtai, Kukita Toshio, Shi Songtao, Nonaka Kazuaki, Yamaza Takayoshi, Long Term Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Utilize for a Feasible Stem Cell Resource for Regenerative Medicine
, Gordon Reserch Conference, Biomaterials and tissue engineering, 2012.07.
Membership in Academic Society
  • Japanese Association of Denal Research
  • International association of Dental research
  • Utility of PDL progenitors for in vivo tissue regeneration: a report of 3 cases.
    F Feng, K Akiyama, Y Liu, T Yamaza, T-M Wang, J-H Chen, BB Wang, G T-J Huang, S Wang, S Shi.
Educational Activities
1. Lecture of Human Anatomy to undergraduate dental students
2. Practical Lecture of Human Anatomy to undergraduate dental students
3. Lecture of Human Oral Anatomy to undergraduate dental students
4. Practical Lecture of Human Oral Anatomy to undergraduate dental students
5. Lecture of Human Development to undergraduate dental students
6. Early exposure to undergraduate dental students
7. Research exposure to undergraduate dental students
8. Scientific instruction to graduate students
9. Scientific instruction to undergraduate students
Other Educational Activities
  • 2010.10.