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Yuzo Ninomiya Last modified date:2020.07.30

Post-doctoral Fellow / Oral Biological Sciences

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Research and Development Center for Five-Sense Devices, Kyushu University .
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Oral Physiology
Total Priod of education and research career in the foreign country
Outline Activities
Outline of research:
Receptor and transduction mechanisms of oral sensory system and its Physiological function
Research projects:
1. Moleculargenetic basis for taste receptor and transduction mechanisms by using genetic variants in mice.
2. Selective synaptic connection between taste cell and axon and its relation to receptor expression.
3. Regeneration and differentiation of taste cells: channel re-expression after cuting taste axons.
4. Mechanisms for occurrence of effects of taste modifiers; gurmarin and strogin.
5. Molecular basis for sweet taste modification by leptin.
6. Neural mechanisms for salivary-protein induction by food.
7. Induction of digestive duice and hormones and physiologically active factors by oral sensory system.
Research Interests
  • Taste signaling mechanisms for the regulation of food intake
    keyword : Dentistry, Signaling mechanism, Neuroscience, Cell,Tissue, Taste
  • Taste signaling mechanisms for the regulation of food intake: approaches to establishment for taste health science
    keyword : Dentistry, Signaling mechanism, Neuroscience, Cell, Tissue, Taste
  • Modulation of cellular, neural and behavioral responses by modal shifts of taste cell sensor signaling
    keyword : Taste receptor, Cell sensor, Energy sensor, homeostasis
Academic Activities
1. Nakamura Y., Sanematsu K, Ohta R., Shirosaki S, Koyano K, Nonaka K, Shigemura N, Ninomiya Y, Diurnal variation of human sweet taste recognition thresholds is correlated with plasma leptin levels, Diabetes, 57; 2661-2665, 2008.10.
2. Talavera K, Yasumatsu K, Yoshida R, Margolskee RF, Voets T, Ninomiya Y, Nilius B, The taste transduction channel TRPM5 is a locus for bitter-sweet taste interactions, The FASEB journal, 22:1343-1355, 2008.05.
3. Shigemura N, Nakao K, Yasuo T, Murata Y, Yasumatsu K, Nakashima A, Katsukawa H, Sako N, Ninomiya Y, Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin, Biochemical and Biophysical Research Communications, 367:356-363, 2008.03.
4. Shigemura N, Ohkuri T, Sadamitsu C, Yasumatsu K, Yoshida R, Beauchamp GK, Bachmanov AA, Ninomiya Y, Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha subunit in mice, American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 294:R66-R75, 2008.01.
5. Hisatsune C, Yasumatsu K, Takahashi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K, Abnormal taste perception in mice lacking the type 3 inositol 1, 4, 5-triphosphate receptor, Journal of Biological Chemistry, 282:37225-37231, 2007.12.
6. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, Daly K, Maillet EL, Ninomiya Y, Mosinger B, Shirazi-Beechey SP, T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1, Proceedings of the National Academy of Sciences of the United States of America, 2007.09.
7. Yasumatsu K, Kusuhara Y, Shigemura N, Ninomiya Y, Recovery of two independent sweet taste systems during regeneration of the mouse chorda tympani nerve after nerve crush, European Journal of Neuroscience, 26:1521-1529, 2007.09.
8. Kalavera K., Ninomiya Y., Winkel C., Voets T., Nilius B, Influence of temperature on taste perception, Cellular Molecular Life Science, 64:377-381, 2007.04.
9. Yoshida R, Yasumatsu K, Shigemura N, *Ninomiya Y, Coding channels for taste perception: information transmission from taste cells to
gustatory nerve fibers
, Archives of Histology and Cytology, 69:233-242, 2006.12.
10. Yoshida R, Shigemura N, Sanematsu K, Yasumatsu K, Ishizuka S, *Ninomiya Y, Taste responsiveness of fungiform taste cells with action potentials, Journal of Neurophysiology, 96:3088-3095, 2006.12.
11. Ohkuri T, Yasumatsu K, Shigemura N, Yoshida R, *Ninomiya Y., Amiloride inhibition on NaCl responses of the chorda tympani nerve in two 129
substrains of mice, 129P3/J and 129X1/SvJ
, Chemical Senses, 31:565-572, 2006.05.
12. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Perez CA, Shigemura N, Yoshida R, Mosinger B Jr, Glendinning JI, Ninomiya Y, Margolskee RF , Trpm5 null mice respond to bitter, sweet, and umami compounds., Chemical Senses, 31:253-264, 2006.04.
13. *Talavera K., Yasumatsu K., Voet T., Droogmans G., Shigemura N., Ninomiya Y., Margolskee RF., and Nilius B., Heat-acivation of the taste channel TRPM5 underlies thermal sensitivity to sweet., Nature, 438:1022-1025, 2005.12.
14. Shigemura N, Ohta R, Kusakabe Y, Miura H, Hino A, Koyano K, Nakashima K, Ninomiya Y, Leptin modulates behavioral responses to sweet substances by influencing peripheral taste structure, Endocrinology, 10.1210/en.2003-0602, 145, 2, 839-847, 145:839-847, 2004.01.
15. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, Jiang P, Ninomiya Y, Margolskee RF, Detection of sweet and umami taste in the absence of taste receptor T1r3, Science, 10.1126/science.1087155, 301, 5634, 850-853, 301:850-853, 2003.01.
16. Yasumatsu K, Katsukawa H, Sasamoto K, Ninomiya Y, Recovery of amiloride-sensitive neural coding during regeneration of the gustatory nerve: Behavioral-neural correlation of salt taste discrimination, J. Neuroscience, 23, 10, 4362-4368, 23:4362-4368, 2003.01.
17. Murata Y, Nakashima K, Yamada A, Shigemura N, Sasamoto K, Ninomiya Y., Gurmarin suppression of licking responses to sweetener-quinine mixtures in C57BL mice, Chemical Senses, 10.1093/chemse/28.3.237, 28, 3, 237-243, 28:237-243, 2003.01.
18. Ohta R., Shigemura N., Sasamoto K., Koyano K. and Ninomiya Y., Conditioned taste aversion learning in leptin-receptor-deficient db/db mice, Nurobiology of Learning and Memory, 10.1016/S1074-7427(03)00046-7, 80, 2, 105-112, 80: 105-112, 2003.01.
19. Ninomiya, Y., Shigemura, N., Ohta, R., Yasumatsu, K., Sugimoto, K., Nakashima, K. and Lindemann, B., Leptin and sweet taste, Vitam. Horm. : 221- (Review), 10.1016/S0083-6729(02)64007-5, 64, 221-248, Vol.248,pp.64, 2002.01.
20. Miura H, Kusakabe, Y, Sugiyama, C, Kawamatsu, M, Ninomiya, Y, Motoyama, J and Hino, A, Shh and Ptc are associated with taste bud maintenance in the adult mouse, Mech. Dev., 10.1016/S0925-4773(01)00414-2, 106, 1-2, 143-145, Vol.106,pp.143-145, 2001.01.
21. Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Molecular genetic identification of a candidate receptor gene for sweet taste, BBRC, 10.1006/bbrc.2001.4760, 283, 1, 236-242, Vol.283,pp.236-242, 2001.01.
22. Kawai, K., Sugimoto, K., Nakashima, K., Miura, H. and Ninomiya, Y., Leptin as a modulator of sweet taste sensitivities in mice, Proc. Natl. Acad. Sci. USA, 10.1073/pnas.190066697, 97, 20, 11044-11049, Vol.97,pp.11044-11049, 2000.01.
23. Ninomiya Y, Nakashima K, Fukuda A, Nishino H, Sugimura T, Hino A, Danilova V, Responses to umami substances in taste bud cells innervated by the chorda tympani and glossopharyngeal nerves, J. Nutr., Vol.130: 950-953, 2000.01.
24. Ninomiya, Y., Imoto, T. and Sugimura, T., Sweet taste responses of mouse chorda tympani neurons: existence of gurmarin-sensitive and -insensitive receptor components, J. Neurophysiol., Vol.81,pp.3087-3091, 1999.01.
25. Ming, D., Ninomiya, Y. and Margolskee, R., Blocking taste receptor activation of gustducin inhibits gustatory responses to bitter compounds, Proc. Natl. Acad. Sci. USA, Vol.97,pp.9903-9908, 1999.01.
26. Katsukawa, H. and Ninomiya, Y., Capsaicin induces cystatin-S-like substances in submandibular saliva of the rat, J. Dent. Res., Vol.78,pp.1609-1616, 1999.01.
27. Nakashima, K. and Ninomiya, Y., The transduction for sweet taste of saccharin may involve both inositol 1-5-triphosphate and cAMP pathways in the fungiform taste buds in C57BL mice., Cell. Physiol. Biochem., Vol.9,No.4,pp.90-98, 1999.01.
28. Katsukawa, H., Imoto, T. and Ninomiya, Y., Induction of salivary gurmarin-binding proteins in rats fed gymnema containing diets, Chem. Senses, Vol.24,pp.387-392, 1999.01.
29. Nakashima, K. and Ninomiya, Y., Increase in inositol 1-5-triphosphate levels of the fungiform papilla in response to saccharin and bitter substances in mice., Cell. Physiol. Biochem., Vol.8,No.4,pp.224-230, 1998.01.
30. Ninomiya, Y., Imoto, T., Yatabe, A., Kawamura, S., Nakashima, K. and Katsukawa, H., Enhanced responses of the chorda tympani nerve to nonsugar sweeteners in the diabetic db/db mice, Am. J. Physiol., 274:R1324-R1330, 1998.01.
31. Kim M, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A, Regional expression patterns of taste receptors and gustducin in the mouse tongue, BBRC, 312:500-506.
1. Yuzo Ninomiya, Neural & molecular mechanisms of taste reception, transduction & modulation: A sweet (taste) story that began with simple Mendel's law, AChemS, 2012.04.
  • selected from recent outstanding researches in taste molecular biology field.
Educational Activities
Graduate School of Dental Sciences:
1. lectures and practical cources for oral neuroscience
2. Electrophysiological experiments

Faculty of Dentistry:
1. Physiology
2. Oral Physiology
Professional and Outreach Activities
Collaborative works:
1. 1999-2003 [Taste modifiers, Diet-inducing salivary proteins] with Rotte Co. Ltd.
2. 2004- [Circadian control on plasma levels of hormone and physiologically active compounds by mastication].