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Takao Shimazoe Last modified date：2022.06.28

Associate Professor / Clinical Pharmacy
Department of Pharmaceutical Health Care and Sciences
Faculty of Pharmaceutical Sciences


Graduate School
Department of Clinical Pharmacy
Graduate School of Pharmaceutical Sciences
Undergraduate School
Department of General Pharmaceutical Sciences
School of Pharmaceutical Sciences
Department of Clinical Pharmacy
School of Pharmaceutical Sciences
Other Organization
Other
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Administration Post
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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/takao-shimazoe
　Reseacher Profiling Tool　Kyushu University Pure
http://www.http://ikuyaku.phar.kyushu-u.ac.jp
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Phone
092-642-6949
Fax
092-642-6949
Academic Degree
Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Pharmacology, Clinical Pharmacy
Total Priod of education and research career in the foreign country
00years06months
Outline Activities
Management of Clinical Pharmacy and Pharmaceutical Care Center.
System construction of Clinical Pharmacy Course.
Cooperation with other organization on long-term practice.
Publication in English and Japanese journal and presentation in overseas and Japanese conferences.
Director of The Health and Medical Science Association
Councilor of Shoshisha Foundation for student and graduate student scholarship
Delegate, councillor and educator of The Japanese Pharmacological Society
Delegate of Medical and Pharmaceutical Society for WAKAN-YAKU
Councillor of Japanese Society for chronobiology
Councillor of The Japanese society of Neuropsychopharmacology
Director of Fukuoka Pharmaceutical Association
Vice President of Fukuoka City Clinical Practice Center
Lecture on drugs and health.
Research
Research Interests
  • Study on prevention and treatment of chemotherapy-induced peripheral neuropathy.
    keyword : chemotherapy, peripheral neuropathy
    2017.01～2025.04.
  • Study for reduction of leftover drugs, Setsuyaku Bag Campaign
    keyword : Setsuyaku Bag, adoherence, leftover drugs
    2012.06～2027.05.
  • Research on importance of diet, Oriental medicine and supplement for prevention and progression of lifestyle-related diseases (diabetes mellitus and cancer)
    keyword : cancer, DM, diet, Oriental medicine, supplement
    2005.02Rple of daily food, Oriental medicine and suppliment on prevention and inhibition of developmet of cancer and doabetes.
  • Research on the role of the suprachiasmatic nucleus on circadian rhythm
    keyword : SCN, circadian rhythm
    1995.04Research on circadian rhythms.
Academic Activities
Books
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1. Cause of diseases and drug treatment with illustration.
Reports
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Papers
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1. Naohiro Iwata, MOSABURO KAINUMA, Kobayashi D, toshio kubota, Naoko Sugawara, Aiko Uchida, Sahoko Ozono, Yuki Yamamuro, Norihiro Furusyo, Koso Ueda, Eiichi Tahara, Takao Shimazoe, The Relation between Hepatotoxicity and the Total Coumarin Intake from Traditional Japanese Medicines Containing Cinnamon Bark, Front Pharmacol, 10.3389/fphar.2016.00174, 7, 214, 2016.05, Cinnamon bark is commonly used in traditional Japanese herbal medicines (Kampo medicines). The coumarin contained in cinnamon is known to be hepatotoxic, and a tolerable daily intake (TDI) of 0.1 mg/kg/day, has been quantified and used in Europe to insure safety. Risk assessments for hepatotoxicity by the cinnamon contained in foods have been reported. However, no such assessment of cinnamon bark has been reported and the coumarin content of Kampo medicines derived from cinnamon bark is not yet known. To assess the risk for hepatotoxicity by Kampo medicines, we evaluated the daily coumarin intake of patients who were prescribed Kampo medicines and investigated the relation between hepatotoxicity and the coumarin intake. The clinical data of 129 outpatients (18 male and 111 female, median age 58 years) who had been prescribed keishibukuryogankayokuinin (TJ-125) between April 2008 and March 2013 was retrospectively investigated. Concurrent Kampo medicines and liver function were also surveyed. In addition to TJ-125, the patients took some of the other 32 Kampo preparations and 22 decoctions that include cinnamon bark. The coumarin content of these Kampo medicines was determined by high performance liquid chromatography (HPLC). TJ-125 had the highest daily content of coumarin (5.63 mg/day), calculated from the daily cinnamon bark dosage reported in the information leaflet inserted in each package of Kampo medicine. The coumarin content in 1g cinnamon bark decoction was 3.0 mg. The daily coumarin intake of the patients was 0.113 (0.049-0.541) mg/kg/day, with 98 patients (76.0%) exceeding the TDI. Twenty-three patients had an abnormal change in liver function test value, but no significant difference was found in the incidence of abnormal change between the group consuming less than the TDI value (6/31, 19.4%) and the group consuming equal to or greater than the TDI value (17/98, 17.3%). In addition, no abnormal change related to cinnamon bark was found for individual patients. This paper was done to assess the risk of hepatotoxicity by the coumarin contained in Kampo medicines and to clarify whether or not the Kampo preparations in general use that contain cinnamon bark may be safely used in clinical practice..
2. Kaori Koyanagi, toshio kubota, Kobayashi D, Taro Kihara, Takeo Yoshida, Takamasa Miisho, Takao Shimazoe, Yoshiko Sakamoto, Jyunichi Takaki, Takashi Seo, Tomoko Miura, Prescription Factors Associated with Medication Non-adherence in Japan Assessed from Leftover Drugs in the SETSUYAKU-BAG Campaign: Focus on Oral Antidiabetic Drugs, Front Pharmacol, 10.3389/fphar.2016.00212. eCollection 2016., 20, 212, 2016.07, Abstract
BACKGROUND:
Medication adherence has an important influence on health outcomes in patients with chronic diseases. However, few studies have been performed in Japan to determine factors related to medication non-adherence.
OBJECTIVE:
The aim of this study was to identify prescription factors related to medication non-adherence by investigating patient characteristics, all prescriptions, and prescriptions for oral antidiabetic drugs (OADs).
METHODS:
A retrospective cross-sectional survey of prescription data about implementation of dosing regimen was performed at community pharmacies engaged in appropriate use of leftover drugs. We evaluated the amount of drugs originally prescribed and the reduced amount after use of leftover drugs, and then calculated prescription reduction ratio (PRR). We analyzed prescription factors contributing to non-adherence based on the PRR.
RESULTS:
Prescription information for 1207 patients was reviewed, revealing that patients were non-adherent to 58% of prescriptions. Lack of a drug copayment, fewer concurrent drugs, and drugs not in single-dose packaging were associated with non-adherence. Among the 1207 patients, 234 prescriptions for diabetes and 452 OAD formulations were included. Forty-seven percent of prescriptions and 29% of the formulations were non-adherent. A higher dosing frequency and preprandial administration were associated with non-adherence. Among the OADs, adherence was lower for α-glucosidase inhibitors and biguanides than for sulfonylureas.
CONCLUSIONS:
Several factors related to patient characteristics, general drug prescriptions, and OAD prescriptions were associated with non-adherence. Further consideration will be needed to improve adherence to medication in Japan. Health care providers should perform more careful monitoring of adherence in patients with the factors identified by this study..
3. Takao Shimazoe, Sachiko Nakamura, Kenji Kobayashi, Shigenori Watanabe, Kyoko Miyasaka, Akira Kono, Akihiro Funakoshi, Role of 5-HT1B receptors in entrainment disorder of Otsuka Long Evans Tokushima Fatty (OLETF) rats, Neuroscience, 10.1016/j.neuroscience.2003.08.024, 123, 1, 201-205, 123, 201-205, 2004.01.
4. Shimazoe T, Morita M, Ogiwara S, Kojiya T, Goto J, Kamakura M, Moriya T, Shinohara K, Takiguchi S, Kono A, Miyasaka K, Funakoshi A, Ikeda M., Cholecystokinin-A receptors regulate photic input pathways to the circadian clock., FASEB Journal, VOL. 22, 1479-1490, 2008.05.
Presentations
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1. Takao Shimazoe, Study on tracing reports from pharmacists to doctors in Japan, The 21st Asian Conference on Clinical Pharmacy, 2022.02.
2. Takao Shimazoe, Collaboration Between Academia and Community Pharmacy Association in Setsuyaku-Bag Campaign of Japan, 2021.07.
3. Takao Shimazoe, Assessment of tracing reports from pharmacists to doctors
in Fukuoka city of Japan
, The 19th Asian Conference on Clinical Pharmacy, 2019.06, We started a new project named Evidence COnstruction by pharmacists Working Group (ECO-WG) last year. In Japan we use tracing reports for the cooperation between pharmacists and doctors. In the tracing reports pharmacists write various contents about patients. However, the influence of the reports are not yet clarified. In ECO-WG, therefore, we assessed the influence of tracing reports from community pharmacists to doctors. At first, we categorized the reported items into 10 factors ,and then, analyzed them. As a result of it, prescription proposal was shown in 23% of the tracing reports. Medication situation and drug request from patients were significantly connected to prescription proposal. We found that medication situation was most important. Prescription proposal was induced by problem of medication situation, possibility of side effects, interaction of drugs and so on. The contents of prescription proposal were support of administration (one dose package, change of dosage forms, application, etc), adjustment (decrease, increase, withdrawal) of drugs, change of drugs. Forty cases from 61 kinds of prescription proposal from pharmacists (65.6%) were adopted by doctors. Then, we fpund that doctors are easu to accept prescription proposal in case that pharmacists proposed it by life style, drug request from patients, leftover drugs. These results suggest that tracing reports from pharmacists to doctors will be able to contribute to the patient treatment..
4. Shimazoe T, Kubota T, Kobayashi D, Kawashiri T, Kihara T, Takaki J, Koyanagi K, Nakashiba T, Kawanami M, Tsuzuki K, Nagatomi S, Tanaka T, Assessment of non-adherence factors using original score sheets in SETSUYAKU-BAG Campaign of Japan, FIP, 2018.09.
5. Takao Shimazoe, Setsuyaku Bag Campaign ~from regulation of leftover drugs to improvement of QOL~, Asian Conference on Clinical Pharmacy 2017, 2017.07, 福岡市薬剤師会、大分市薬剤師会との共同研究である節薬バッグ運動の経緯と成果につて発表した。.
6. Takao Shimazoe, Improvement of adherence and QOL in Setsuyaku Bag Campaign, The 16th Asian Conference on Clinical Pharmacy, 2016.07.
7. Takao Shimazoe, Advancement of the campaign on regulation of leftover drugs for outpatients called "Setsuyaku Bag Campaign" in Fukuoka of Japan, The 15th Asian Conference on Clinical Pharmacy, 2015.11, Our campaign named "Setsuyaku Bag Campaign2 developed more and more. From now, we will focus on the improvement of QOL in patients..
8. 島添 隆雄, Advancement of the campaign on regulation of leftover drugs for outpatients called "Setsuyaku Bag Campaign" in Fukuoka of Japan, The 15th Asian Conference on Clinical Pharmacy, 2015.06, 福岡市薬剤師会との共同事業「節薬バッグ運動」の展開についてPlenary lectureを行った。.
9. 島添 隆雄, Expansion of campaign on regulation of leftover drugs for outpatients, The 14th Asian Conference on Clinical Pharmacy, 2014.11, 福岡市薬剤師会との共同事業「節薬バッグ運動」を福岡市医療件に拡大し、データを解析した。その結果、１枚の処方せんあたり２割が削減できることが明らかになった。.
10. Takao Shimazoe, Study on Left Drugs of Patients to Raise Adherence in Community Pharmacy
, 2013.09, In Japan, increase of medical expenses produces many economical deficits. Therefore, the reduction is a critical issue for us. However, patients sometimes forget or stop taking medicines. Confirmation of leftover drugs by pharmacists is required to get patient education fee by revision of the law. Some reports suggest that more than 40 % of prescribed drugs are kept in patient’s home. When such leftover drugs are reconsidered, it will produce much economical merit. Therefore, if pharmacists regulate prescription by suggestion to doctors, significant reduction of medical deficits will be also possible. Fukuoka Pharmaceutical Association started the trial of campaign for reduction of leftover drugs (Setsuyaku Bag Campaign) to citizens with our department in Kyushu University for 3 months in this winter. This campaign is as follows. Pharmacists distributed convenient bags named Setsuyaku Bags to the patients. The patients put leftover drugs in, and brought them to the community pharmacies. The pharmacists checked them, and conducted prescription question to the doctors. Then, the doctors changed prescriptions. The pharmacists recorded the details in the cheksheets and sent them to us. We assessed them from various points of view. Thirty-one community pharmacies of Fukuoka city joined in this trial. Total number of patients was 252. Saved amount was 839,665 Japanese yen (1,000 US$). The amount estimates 300,000,000,000 Japanese yen when it spreads to all of Japan. These results suggest that control of prescription by pharmacists can contribute to saving of medical fees. Moreover, such a try will connect to mutual understanding within patients, doctors and pharmacists as team-based medicine. It will connect to proper prescription and proper use in near future. In this spring, this campaign was spread to all of Fukuoka city. I will also present the results in ACCP 2013..
11. Takao Shimazoe, New Epoch of Clinical Pharmacy Education from Students to Pharmacists in Japan, The 12th Asian Conference on Clinical Pharmacy, 2012.07, The skill of physical assessment will be indispensable for pharmacists both in hospital and community pharmacy.
Multidisciplinary care (team based care) will be more and more important in near future .
.
12. Commit our dream of multidisciplinary care to health care system students.
13. Effect of caffeine on glucose metabolism and inflammatory marker level for moderate obese people.
14. Education of a pharmacist who will have splendid faculty to be a leader of them.
15. アマクリン細胞コレシストキニンA受容体を介した体内時計入力における網膜信号プロセス.
Membership in Academic Society
  • Medical and Pharmaceutical Society for WAKAN-YAKU
  • Health and Medical Science Association
  • The Japan Society for Oriental Medicine
  • Japanese Pharmaceutical Association
  • Japanese Society of Pharmaceutical Health Care and Sciences
Awards
  • We got excellent award in BI Pharmacist Award 2014.
Educational
Educational Activities
Research support and Education of graduate students and students in Department of Clinical Pharmacy and Pharmaceutical care
Lecture for students and graduate students.
Education for pharmaceutical practice of students.
Planning and enforcement of hospital and drug store visiting as early exposure.
Education for pure-practice.
Responsible person on OSCE.
CBT member
Social
Professional and Outreach Activities
A board member of Asian Conference on Clinical Pharmacy
Attendance in 2 day meeting and Pharmaceutical Care Symposium of Fukuoka Pharmaceutical Association as a chairman.


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