Kyushu University Academic Staff Educational and Research Activities Database
List of Papers
Kenji Hamase Last modified date:2024.03.08

Professor / Department of Chemo-Pharmaceutical Sciences / Faculty of Pharmaceutical Sciences


Papers
1. Yuri NAGATA, Takeyuki AKITA, Aogu FURUSHO, Chiharu ISHII, Masashi MITA, Kenji HAMASE, Design of novel mixed-mode columns for analysis of amino acids derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole and the evaluation of retention properties, Chromatography, 10.15583/jpchrom.2023.006, 44, 83-87, 2023.04.
2. Chiharu ISHII, Rin MORINAGA, Miho TAKAHASHI, Masashi MITA, Takeyuki AKITA, Kenji HAMASE, Development of a three-dimensional HPLC system for acidic amino acid enantiomers and determination of their amounts in mice lacking D-aspartic acid oxidase activity, Journal of Pharmaceutical and Biomedical Analysis Open, 10.1016/j.jpbao.2023.100004, 1, 100004, 2023.01.
3. Yusuke GONDA, Akina MATSUDA, Kenichiro ADACHI, Chiharu ISHII, Masataka SUZUKI, Akina OSAKI, Masashi MITA, Naoto NISHIZAKI, Yoshiyuki OHTOMO, Toshiaki SHIMIZU, Masato YASUI, Kenji HAMASE, Jumpei SASABE, Mammals sustain amino acid homochirality against chiral conversion by symbiotic microbes, Proceedings of the National Academy of Sciences of the United States of America, 10.1073/pnas.2300817120, 120, e2300817120, 2023.03, Mammals exhibit systemic homochirality of amino acids in L-configurations. While ribosomal protein synthesis requires rigorous chiral selection for L-amino acids, both endogenous and microbial enzymes convert diverse L-amino acids to D-configurations in mammals. However, it is not clear how mammals manage such diverse D-enantiomers. Here, we show that mammals sustain systemic stereo dominance of L-amino acids through both enzymatic degradation and excretion of D-amino acids. Multidimensional high performance liquidchromatography analyses revealed that in blood, humans and mice maintain D-amino acids at less than several percent of the corresponding L-enantiomers, while D-amino acids comprise ten to fifty percent of the L-enantiomers in urine and feces. Germ-free experiments showed that vast majority of D-amino acids, except for D-serine, detected in mice are of microbial origin. Experiments involving mice that lack enzymatic activity to catabolize D-amino acids showed that catabolism is central to the elimination of diverse microbial D-amino acids, whereas excretion into urine is of minor importance under physiological conditions. Such active regulation of amino acid homochirality depends on maternal catabolism during the prenatal period, which switches developmentally to juvenile catabolism along with the growth of symbiotic microbes after birth. Thus, microbial symbiosis largely disturbs homochirality of amino acids in mice, whereas active host catabolism of microbial D-amino acids maintains systemic predominance of L-amino acids. Our findings provide fundamental insight into how the chiral balance of amino acids is governed in mammals and further expand the understanding of interdomain molecular homeostasis in host-microbial symbiosis..
4. Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Ryuichi KONNO, Kenji HAMASE, Chiral amino acid analysis in the plasma of B6DAO-/- mice lacking D-amino acid oxidase activity, Chromatography, 10.15583/jpchrom.2023.002, 44, 39-43, 2023.02.
5. Akina OSAKI, Marie AOYAMA, Masashi MITA, Kenji HAMASE, Masato YASUI, Jumpei SASABE, Endogenous D-serine exists in the mammalian brain independent of synthesis by serine racemase, Biochemical and Biophysical Research Communications, 10.1016/j.bbrc.2022.12.037, 641, 186-191, 2022.12.
6. Hiroshi NARAOKA, Yoshinori TAKANO, Jason P. DWORKIN, Yasuhiro OBA, Kenji HAMASE, Aogu FURUSHO, Nanako O. OGAWA, Minako HASHIGUCHI, Kazuhiko FUKUSHIMA, Dan AOKI, Philippe Schmitt-KOPPLIN, José C. APONTE, Eric T. PARKER, Daniel P. GLAVIN, Hannah L. McLAIN, Jamie E. ELSILA, Heather V. GRAHAM, John M. EILER, Francois-Regis Orthous-DAUNAY, Cédric WOLTERS, Junko ISA, Véronique VUITTON, Roland THISSEN, Saburo SAKAI, Toshihiro YOSHIMURA, Toshiki KOGA, Naohiko OHKOUCHI, Yoshito CHIKARAISHI, Haruna SUGAHARA, Hajime MITA, Yoshihiro FURUKAWA, Norbert HERTKORN, Alexander RUF, Hisayoshi YURIMOTO, Tomoki NAKAMURA, Takaaki NOGUCHI, Ryuji OKAZAKI, Hikaru YABUTA, Kanako SAKAMOTO, Shogo TACHIBANA, Harold C. CONNOLLY, Jr., Dante S. LAURETTA, Masanao ABE, Toru YADA, Masahiro NISHIMURA, Kasumi YOGATA, Aiko NAKATO, Miwa YOSHITAKE, Ayako SUZUKI, Akiko MIYAZAKI, Shizuho FURUYA, Kentaro HATAKEDA, Hiromichi SOEJIMA, Yuya HITOMI, Kazuya KUMAGAI, Tomohiro USUI, Tasuku HAYASHI, Daiki YAMAMOTO, Ryota FUKAI, Kohei KITAZATO, Seiji SUGITA, Noriyuki NAMIKI, Masahiko ARAKAWA, Hitoshi IKEDA, Masateru ISHIGURO, Naru HIRATA, Koji WADA, Yoshiaki ISHIHARA, Rina NOGUCHI, Tomokatsu MOROTA, Naoya SAKATANI, Koji MATSUMOTO, Hiroki SENSHU, Rie HONDA, Eri TATSUMI, Yasuhiro YOKOTA, Chikatoshi HONDA, Tatsuhiro MICHIKAMI, Moe MATSUOKA, Akira MIURA, Hirotomo NODA, Tetsuya YAMADA, Keisuke YOSHIHARA, Kosuke KAWAHARA, Masanobu OZAKI, Yu-ichi IIJIMA, Hajime YANO, Masahiko HAYAKAWA, Takahiro IWATA, Ryudo TSUKIZAKI, Hirotaka SAWADA, Satoshi HOSODA, Kazunori OGAWA, Chisato OKAMOTO, Naoyuki HIRATA, Kei SHIRAI, Yuri SHIMAKI, Manabu YAMADA, Tatsuaki OKADA, Yukio YAMAMOTO, Hiroshi TAKEUCHI, Atsushi FUJII, Yuto TAKEI, Kento YOSHIKAWA, Yuya MIMASU, Go ONO, Naoko OGAWA, Shota KIKUCHI, Satoru NAKAZAWA, Fuyuto TERUI, Satoshi TANAKA, Takanao SAIKI, Makoto YOSHIKAWA, Sei-ichiro WATANABE, Yuichi TSUDA, Soluble organic molecules in samples of the carbonaceous asteroid (162173) Ryugu, Science,, 10.1126/science.abn9033, 379, eabn9033, 2023.02, The Hayabusa2 spacecraft collected samples from the surface of the carbonaceous near-Earth asteroid (162173) Ryugu and brought them to Earth. The samples were expected to contain organic molecules, which record processes that occurred in the early Solar System. We analyzed organic molecules extracted from the Ryugu surface samples. We identified a variety of molecules containing the atoms CHNOS, formed by methylation, hydration, hydroxylation, and sulfurization reactions. Amino acids, aliphatic amines, carboxylic acids, polycyclic aromatic hydrocarbons, and nitrogen-heterocyclic compounds were detected, which had properties consistent with an abiotic origin. These compounds likely arose from an aqueous reaction on Ryugu’s parent body and are similar to the organics in Ivuna-type meteorites. These molecules can survive on the surfaces of asteroids and be transported throughout the Solar System..
7. Yusuke NAKADE, Yasunori IWATA, Norihiko SAKAI, Masashi MITA, Maiko NAKANE, Kenji HAMASE, Wataru SUDA, Tadashi TOYAMA, Shinji KITAJIMA, Akinori HARA, Miho SHIMIZU, Chikako OGUSHI, Kengo FURUICHI, Yoshitaka KOSHINO, Hidetoshi MORITA, Masahira HATTORI, Takashi WADA, Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus, Scientific Reports, 10.1038/s41598-022-26175-1, 12, 21773, 2022.12.
8. Yutaka KONYA, Yoshihiro IZUMI, Kenji HAMASE, Takeshi BAMBA, Ultrafast simultaneous chiral analysis of native amino acid enantiomers using supercritical fluid chromatography/tandem mass spectrometry, Journal of Chromatography A, 10.1016/j.chroma.2022.463305, 1677, 463305, 2022.07.
9. Yusuke GONDA, Chiharu ISHII, Masashi MITA, Naoto NISHIZAKI, Yoshiyuki OHTOMO, Kenji HAMASE, Toshiaki SHIMIZU, Jumpei SASABE, Astrocytic D-amino acid oxidase degrades D-serine in the hindbrain, FEBS Letters, 10.1002/1873-3468.14417, 596, 2889-2897, 2022.06.
10. Hsin-Miao TSAI, Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE Kenji HAMASE, Two-dimensional chiral HPLC analysis of lactate, hydroxybutyrates and malate in human plasma, Chromatography, 10.15583/jpchrom.2022.011, 43, 119-126, 2022.10.
11. Takako HAYASHI, Kenji HAMASE, Simultaneous determination of seven β2-agonists in livestock products using an LC-MS/MS system, Chromatography, 10.15583/jpchrom.2022.005, 43, 101-109, 2022.07.
12. Chiharu ISHII, Noburo TAKIZAWA, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Ryuichi KONNO, Kenji HAMASE, Off-line two-dimensional LC-MS/MS determination of tryptophan enantiomers in mammalian urine and alteration of their amounts in D-amino acid oxidase deficient mice, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2022.114919, 219, 114919, 2022.06.
13. Mai OYAIDE, Chiharu ISHII, Akira FUJII, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Kenji HAMASE, Enantioselective determination of hydroxy amino acids in Japanese traditional amber rice vinegars, Chromatography, 10.15583/jpchrom.2022.006, 43, 59-65, 2022.05.
14. Mai OYAIDE, Aogu FURUSHO, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development of an off-line heart cutting two-dimensional HPLC system for enantioselective analysis of serine, threonine and allo-threonine in human physiological fluids, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2022.114807, 217, 114807, 2022.04.
15. Yasunori IWATA, Yusuke NAKADE, Shinji KITAJIMA, Shiori YONEDA-NAKAGAWA, Megumi OSHIMA, Norihiko SAKAI, Hisayuki OGURA, Koichi SATO, Tadashi TOYAMA, Yuta YAMAMURA, Taro MIYAGAWA, Hiroka YAMAZAKI, Akinori HARA, Miho SHIMIZU, Kengo FURUICHI, Masashi MITA, Kenji HAMASE, Tomohiro TANAKA, Motohiro NISHIDA, Wataru MURAMATSU, Hisashi YAMAMOTO, Shigeyuki SHICHINO, Satoshi UEHA, Kouji MATSUSHIMA, Takashi WADA, Protective effect of D-alanine against acute kidney injury, American Journal of Physiology, Renal Physiology, 10.1152/ajprenal.00198.2021, 322, F667-F679, 2022.04.
16. Siew Hwei YAP, Cheng Siang LEE, Aogu FURUSHO, Chiharu ISHII, Syahirah SHAHARUDIN, Nurul Syuhada ZULHAIMI, Adeeba KAMARULZAMAN, Shahrul Bahyah KAMARUZZAMAN, Masashi MITA, Kok Hoong LEONG, Kenji HAMASE, Reena RAJASURIAR, Plasma D-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV, AIDS, 10.1097/QAD.0000000000003207, 36, 911-921, 2022.01.
17. Masataka SUZUKI, Ryoko SHIMIZU-HIROTA, Masashi MITA, Kenji HAMASE, Jumpei SASABE, Chiral resolution of plasma amino acids reveals enantiomer-selective associations with organ functions, Amino Acids, 10.1007/s00726-022-03140-w, 54, 421-432, 2022.02.
18. Aogu FURUSHO, Karina Akemy IKEJIRI, Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Tomomi IDE, Kenji HAMASE, Two-dimensional high-performance liquid chromatographic determination of chiral amino acids in food samples and human physiological fluids using fluorescence derivatization with 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole, Chromatography, 10.15583/jpchrom.2021.020, 43, 29-35, 2022.01.
19. Chinatsu SHINOZAKI, Keita KOHNO, Mitsunori SHIROISHI, Daisuke TAKAHASHI, Yu YOSHIKAWA, Yoshito ABE, Kenji HAMASE, Makoto NAKAKIDO, Kohei TSUMOTO,Kazuhide INOUE, Makoto TSUDA, Tadashi UEDA, Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions, Scientific Reports, 10.1038/s41598-021-03784-w, 12, 131, 2022.01.
20. Chin-Ling HSIEH, Chiharu ISHII, Takeyuki AKITA, Akira FUJII, Kazunori HASHIGUCHI, Masanobu NAGANO, Masashi MITA, Jen-Ai LEE, Kenji HAMASE, Chiral analysis of lactate in various food samples including Japanese traditional amber rice vinegar and the developmental changes during fermentation processes, Chromatography, 10.15583/jpchrom.2021.017, 42, 151-158, 2021.10.
21. Takako HAYASHI, Kenji HAMASE, Determination of clenbuterol in various edible parts of livestock products by LC-MS/MS and LC-MS/MS/MS methods, Chromatography, 10.15583/jpchrom.2020.021, 42, 43-48, 2021.01.
22. Masataka SUZUKI, Tomohisa SUJINO, Sayako CHIBA, Yosuke HARADA, Motohito GOTO, Riichi TAKAHASHI, Masashi MITA, Kenji HAMASE, Takanori KANAI, Mamoru ITO, Matthew K.WALDOR, Masato YASUI, Jumpei SASABE, Host-microbe cross-talk governs amino acid chirality to regulate survival and differentiation of B cells, Science Advances, 10.1126/sciadv.abd6480, 7, eabd6480, 2021.01.
23. Chin-Ling HSIEH, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Development of a selective three-dimensional HPLC system for enantiomer discriminated analysis of lactate and 3-hydroxybutyrate in human plasma and urine, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2020.113871, 195, 113871, 2020.12.
24. Yuta KOHRO, Tsuyoshi MATSUDA, Kohei YOSHIHARA, Keita KOHNO, Keisuke KOGA, Ryuichi KATSURAGI, Takaaki OKA, Ryoichi TASHIMA, Sho MUNETA, Takuya YAMANE, Shota OKADA, Kazuya MOMOKINO, Aogu FURUSHO, Kenji HAMASE, Takumi OTI, Hirotaka SAKAMOTO, Kenichiro HAYASHIDA, Ryosuke KOBAYASHI, Takuro HORII, Izuho HATADA, Hidetoshi TOZAKI-SAITOH, Katsuhiko MIKOSHIBA, Verdon TAYLOR, Kazuhide INOUE, Makoto TSUDA, Spinal astrocytes in superficial laminae gate brainstem descending control of mechanosensory hypersensitivity, Nature Neuroscience, 10.1038/s41593-020-00713-4, 23, 11, 1376-1387, 2020.10.
25. Sui-Wen HSIAO, Chiharu ISHII, Aogu FURUSHO, Chin-Ling HSIEH, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tadashi OKAMURA, Ryuichi KONNO, Tomomi IDE, Ching-Kuo LEE, Kenji HAMASE, Determination of phenylalanine enantiomers in the plasma and urine of mammals and D-amino acid oxidase deficient rodents using two-dimensional high-performance liquid chromatography, Biochimica et Biophysica Acta - Proteins and Proteomics, 10.1016/j.bbapap.2020.140540, 1869, 140540, 2021.01.
26. Aogu FURUSHO, Mintranee OBROMSUK, Takeyuki AKITA, Masashi MITA, Masanobu NAGANO, Pornchai ROJSITTHISAK, Kenji HAMASE, High-performance liquid chromatographic determination of chiral amino acids using pre-column derivatization with o-phthalaldehyde and N-tert-butyloxycarbonyl-D-cysteine and application to vinegar samples, Chromatography, 10.15583/jpchrom.2020.015, 41, 147-151, 2020.09.
27. Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Hiroshi NARAOKA, Kenji HAMASE, Three-dimensional high-performance liquid chromatographic analysis of chiral amino acids in carbonaceous chondrites, Journal of Chromatography A, 10.1016/j.chroma.2020.461255, 1625, 461255, 2020.08.
28. Manabu NAKAZONO, Shinkoh NANBU, Takeyuki AKITA, Kenji HAMASE, Chemiluminescence of methoxycarbonylphenyl 10-methyl-10λ4-2,7-disubstituted acridine-9-carboxylate derivatives, Journal of Photochemistry & Photobiology, A: Chemistry, 10.1016/j.jphotochem.2020.112851, 403, 112851, 2020.08.
29. Masumi KATANE, Risa MOTODA, Makoto ARIYOSHI, Shuhei TATEISHI, Kazuki NAKAYAMA, Yasuaki SAITOH, Tetsuya MIYAMOTO, Masae SEKINE, Masashi MITA, Kenji HAMASE, Satoaki MATOBA, Kumiko SAKAI-KATO, Hiroshi HOMMA, A colorimetric assay method for measuring D-glutamate cyclase activity, Analytical Biochemistry, 10.1016/j.ab.2020.113838, 605, 113838, 2020.07.
30. Yukiko SHIMIZU, Chiharu ISHII, Reiko YANOBU-TAKANASHI, Kenta NAKANO, Akio IMAIKE, Masashi MITA, Kenji HAMASE,Tadashi OKAMURA, D-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats, Biochimica et Biophysica Acta - Proteins and Proteomics, 10.1016/j.bbapap.2020.140463, 1868, 9, 140463, 2020.06.
31. Po-Yeh LIN, Shih-Ming CHEN, Chin-Ling HSIEH, Chia-Yu LIN, Yu-Shen HUANG, Kenji HAMASE, Jen-Ai LEE, Determination of temporal changes in serum and urinary lactate and 3-hydroxybutyrate enantiomers in mice with nephrotoxic serum nephritis by multi-dimensional HPLC, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2020.113367, 188, 113367, 2020.05.
32. Chun-Fang CHANG, Kenji HAMASE, Makoto TSUNODA, Analysis of total thiols in the urine of a cystathionine β-synthase-deficient mouse model of homocystinuria using hydrophilic interaction chromatography, Molecules, 10.3390/molecules25071735, 25, 1735, 2020.04.
33. Masataka SUZUKI, Yusuke GONDA, Marina YAMADA, Arno A. VANDEBROEK,Masashi MITA, Kenji HAMASE, Masato YASUI, Jumpei SASABE, Serum D-serine accumulation after proximal renal tubular damage involves, neutral amino acid transporter Asc-1, Scientific Reports, 10.1038/s41598-019-53302-2, 9, 16705, 2019.11.
34. Yasutaka NAKASHIMA, Yasunari SAKAI, Yumi MIZUNO, Kenji FURUNO, Keiichi HIRONO, Shinichi TAKATSUKI, Hiroyuki SUZUKI,Yoshihiro ONOUCHI, Tohru KOBAYASHI, Kazuhiro TANABE, Kenji HAMASE, Tomofumi MIYAMOTO, Ryohei AOYAGI, Makoto ARITA, Kenichiro YAMAMURA, Tamami TANAKA, Hisanori NISHIO, Hidetoshi TAKADA, Shouichi OHGA, Toshiro HARA, Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease, Cardiovascular Research, 10.1093/cvr/cvz305, 117, 1, 96-108, 2021.01.
35. Aogu FURUSHO, Reiko KOGA, Takeyuki AKITA, Masashi MITA, Tomonori KIMURA, Kenji HAMASE, Three-dimensional high-performance liquid chromatographic determination of Asn, Ser, Ala, and Pro enantiomers in the plasma of patients with chronic kidney disease, Analytical Chemistry, 91, 11569-11575, 2019.09.
36. Atsushi HESAKA, Keiko YASUDA, Shinsuke SAKAI, Hiroaki YONISHI, Tomoko NAMBA-HAMANO, Atsushi TAKAHASHI, Masayuki MIZUI, Kenji HAMASE, Rakan MATSUI, Masashi MITA, Masaru HORIO, Yoshitaka ISAKA, Tomonori KIMURA, Dynamics of D-serine reflected the recovery course of a patient with rapidly progressive glomerulonephritis, CEN Case Reports, 10.1007/s13730-019-00411-6, 8, 297-300, 2019.07.
37. Hiroshi NARAOKA, Minako HASHIGUCHI, Yu SATO, Kenji HAMASE, New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials, Life, 10.3390/life9030062, 62, 9, 9030062, 2019.07.
38. Manabu NAKAZONO, Shinkoh NANBU, Takeyuki AKITA, Kenji HAMASE, Synthesis, chemiluminescence, and application of 2,4-disubstituted phenyl 10-methyl-10λ4-acridine-9-carboxylates, Dyes and Pigments, 10.1016/j.dyepig.2019.107628, 170, 107628, 2019.06.
39. Chiharu ISHII, Takeyuki AKITA, Masanobu NAGANO, Masashi MITA, Kenji HAMASE, Determination of chiral amino acids in various fermented products using a two-dimensional HPLC-MS/MS system, Chromatography, 10.15583/jpchrom.2019.011, 40, 83-87, 2019.05.
40. Chin-Ling HSIEH, Po-Yeh LIN, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Development of a three-dimensional HPLC system for the simultaneous determination of lactate and 3-hydroxybutyrate enantiomers in mammalian urine, CHROMATOGRAPHY, 10.15583/jpchrom.2018.021, 40, 25-32, 2019.02.
41. Atsushi HESAKA, Shinsuke SAKAI, Kenji HAMASE, Tatsuhiko IKEDA, Rakan MATSUI, Masashi MITA, Masaru HORIO, Yoshitaka ISAKA, Tomonori KIMURA, D-Serine reflects kidney function and diseases, Scientific Reports, 10.1038/s41598-019-41608-0, 9, 5104, 2019.01.
42. Yukiko SHIMIZU, Rieko YANOBU-TAKANASHI, Kenta NAKANO, Kenji HAMASE, Toshiaki SHIMIZU, Tadashi OKAMURA, A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats, Mammalian Genome, 10.1007/s00335-018-9790-3, 30, 23-33, 2018.12.
43. Yusuke NAKADE, Yasunori IWATA, Kengo FURUICHI, Masashi MITA, Kenji HAMASE, Ryuichi KONNO, Taito MIYAKE, Norihiko SAKAI, Shinji KITAJIMA, Tadashi TOYAMA, Yasuyuki SHINOZAKI, Akihiro SAGARA, Taro MIYAGAWA, Akinori HARA, Miho SHIMIZU, Yasutaka KAMIKAWA, Kouichi SATO, Megumi OSHIMA, Shiori YONEDA-NAKAGAWA, Yuta Yamamura, Shuichi KANEKO, Tetsuya MIYAMOTO, Masumi KATANE, Hiroshi HOMMA, Hidetoshi MORITA, Wataru SUDA, Masahira HATTORI, Takashi WADA, Gut microbiota-derived D-serine protects from acute kidney injury, JCI Insight, 10.1172/jci.insight.97957, 3, e97957, 2018.10.
44. Kenji HAMASE,Tatsuhiko IKEDA, Chiharu ISHII, Shoto ISHIGO, Kei MASUYAMA, Takeyuki AKITA, Aogu FURUSHO, Miho TAKAHASHI, Tomomi IDE, Masashi MITA , Determination of trace amounts of chiral amino acids in complicated biological samples using two-dimensional high-performance liquid chromatography with an innovative “Shape-Fitting” peak identification/quantification method, Chromatography, 10.15583/jpchrom.2018.019, 39, 147-152, 2018.10.
45. Masumi KATANE, Makoto ARIYOSHI, Shuhei TATEISHI, Sachi KOIWAI, Kaoruko TAKAKU, Kenichiro NAGAI, Kazuki NAKAYAMA, Yasuaki SAITOH, Tetsuya MIYAMOTO, Masae SEKINE, Masashi MITA, Kenji HAMASE, Satoaki MATOBA, Hiroshi HOMMA, Structural and enzymatic properties of mammalian D-glutamate cyclase, Archives of Biochemistry and Biophysics, 10.1016/j.abb.2018.07.005, 654, 10-18, 2018.09.
46. Chiharu ISHII, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Kenji HAMASE, Development of an online two-dimensional high-performance liquid chromatographic system in combination with tandem mass spectrometric detection for enantiomeric analysis of free amino acids in human physiological fluid, Journal of Chromatography A, 10.1016/j.chroma.2018.07.076, 1570, 91-98, 2018.07.
47. Aogu FURUSHO,Reiko KOGA,Takeyuki AKITA,Yurika MIYOSHI,Masashi MITA,Kenji HAMASE, Development of a highly-sensitive two-dimensional HPLC system with narrowbore reversed-phase and microbore enantioselective columns and application to the chiral amino acid analysis of the mammalian brain, Chromatography, DOI:10.15583/jpchrom.2018.007, 39, 83-90, 2018.04.
48. Nutchaya SEREEKITTIKUL, Reiko KOGA, Takeyuki AKITA,Aogu FURUSHO,Roland REISCHL,Masashi MITA, Akira FUJII,Kazunori HASHIGUCHI, Masanobu NAGANO, Wolfgang LINDNER, Kenji HAMASE, Multi-dimensional HPLC analysis of serine containing chiral dipeptides in Japanese traditional amber rice vinegar, Chromatography, 10.15583/jpchrom.2018.002, 39, 59-66, 2018.03.
49. Chin-Ling HSIEH, Reiko KOGA, Aogu FURUSHO, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Jen-Ai LEE, Kenji HAMASE, Enantioselective and simultaneous determination of lactate and 3-hydroxybutyrate in human plasma and urine using a narrowbore online two-dimensional HPLC system, Journal of Separation Science,, 10.1002/jssc.201701283, 41, 1298-1306, 2018.01.
50. Chiharu ISHII, Tetsuya MIYAMOTO, Shoto ISHIGO, Yurika MIYOSHI, Masashi MITA, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Two-dimensional HPLC-MS/MS determination of multiple D-amino acid residues in the proteins stored under various pH conditions, Chromatography, 10.15583/jpchrom.2017.009, 38, 65-72, 2017.05.
51. Makoto ARIYOSHI, Masumi KATANE, Kenji HAMASE, Yurika MIYOSHI, Maiko NAKANE, Atsushi HOSHINO, Yoshifumi OKAWA, Yuichiro MITA, Satoshi KAIMOTO, Motoki UCHIHASHI, Kuniyoshi FUKAI, Kazunori ONO, Syuhei TATEISHI, Daichi HATO, Ryoetsu YAMANAKA, Sakiko HONDA, Yohei FUSHIMURA, Eri IWAI-KANAI, Naotada ISHIHARA, D-Glutamate is metabolized in the heart mitochondria, Scientific Reports, 10.1038/srep43911, 7, 43911, 2017.03.
52. Akiko MORIKAWA, Hideoki FUKUOKA, Keiko UEZONO, Masashi MITA, Satoru KOYANAGI, shigehiro OHDO, Kiyoshi ZAITSU, Kenji HAMASE, Sleep-awake profile related circadian D-alanine rhythm in human serum and urine, Chromatography, 10.15583/jpchrom.2017.003, 38, 53-58, 2017.03.
53. Muneki ISOKAWA, Kentaro KOBAYASHI, Yurika MIYOSHI, Masashi MITA, Takashi FUNATSU, Kenji HAMASE, Makoto TSUNODA, Quantification of biological thiols in the plasma of a homocystinuria model with cystathionine β-synthase deficiency utilizing hydrophilic interaction liquid chromatography and fluorescence detection, Chromatography, 10.15583/jpchrom.2016.015, 37, 147-151, 2016.09.
54. Jumpei Sasabe, Yurika Miyoshi, Seth Rakoff-NAHOUM, Ting ZHANG, Masashi MITA, Brigid M. DAVIS, Kenji HAMASE, Matthew K. WALDOR, Interplay between microbial D-amino acids and host D-amino acid oxidase modifies murine mucosal defence and gut microbiota, Nature Microbiology, 10.1038/nmicrobiol.2016.125, 1, 16125, 2016.07.
55. Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system, Journal of Chromatography A, 10.1016/j.chroma.2016.07.053, 1467, 312-317, 2016.07.
56. Tomonori KIMURA, Kenji HAMASE, Yurika MIYOSHI, Ryohei YAMAMOTO, Keiko YASUDA, Masashi MITA, Hiromi RAKUGI, Terumasa HAYASHI, Yoshitaka ISAKA, Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease, Scientific Reports, 10.1038/srep26137, 6, 6, 26137, 2016.05.
57. Reiko KOGA, Yurika MIYOSHI, Yu SATO, Masashi MITA, Ryuichi KONNO, Wolfgang LINDNER, Kenji HAMASE, Enantioselective determination of phenylalanine, tyrosine and 3,4-dihydroxyphenylalanine in the urine of D-amino acid oxidase deficient mice using two-dimensional high-performance liquid chromatography, Chromatography, 10.15583/jpchom.2015.040, 37, 1, 15-22, 2016.01.
58. Minoru TANIGAWA, Chihiro SUZUKI, Kimio NIWANO, Rensuke KANEKATSU, Hiroyuki TANAKA, Kihachiro HORIIKE, Kenji HAMASE, Yoko NAGATA, Participation of D-serine in the development and reproduction of the silkworm Bombyx mori, Journal of Insect Physiology, 10.1016/j.jinsphys.2016.01.006, 87, 20-29, 2016.01.
59. Tsubasa OYAMA, Rie NAGAI, Mayumi FUJIMOTO, Ryoko KONISHI, Masashi MITA, Keiko UEZONO, Kiyoshi ZAITSU, Kenji HAMASE, Development of a fully-automated on-line oxidation column-switching HPLC system for the determination of endogenous melatonin in human clinical samples, Analytical Sciences, 10.2116/analsci.31.1129, 31, 11, 1129-1135, 2015.11.
60. Shu-Ling LIU, Tsubasa OYAMA, Yurika MIYOSHI, Shiow-Yunn SHEU, Masashi MITA, Tomomi IDE, Wolfgang LINDNER, Kenji HAMASE, Jen-Ai LEE, Establishment of a two-dimensional chiral HPLC system for the simultaneous detection of lactate and 3-hydroxybutyrate enantiomers in human clinical samples, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2015.05.036, 116, 80-85, 2015.06.
61. Tsubasa OYAMA, Eiichi NEGISHI, Hirohisa ONIGAHARA, Nao KUSANO, Yurika MIYOSHI, Masashi MITA, Manabu NAKAZONO, Sumio OHTSUKI, Akio OJIDA, Wolfgang LINDNER, Kenji HAMASE, Design and synthesis of a novel pre-column derivatization reagent with a 6-methoxy-4-quinolone moiety for fluorescence and tandem mass spectrometric detection and its application to chiral amino acid analysis, Journal of Pharmaceutical and Biomedical Analysis, DOI:10.1016/j.jpba.2015.05.039, 116, 71-79, 2015.06.
62. Shoto ISHIGO, Eiichi NEGISHI, Yurika MIYOSHI, Hirohisa ONIGAHARA, Masashi MITA, Tetsuya MIYAMOTO, Haruhiko MASAKI, Hiroshi HOMMA, Tadashi UEDA, Kenji HAMASE, Establishment of a two-dimensional HPLC-MS/MS method combined with DCl/D2O hydrolysis for the determination of trace amounts of D-amino acid residues in proteins, Chromatography, 10.15583/jpchrom.2015.017, 36, 45-50, 2015.05.
63. Hai HAN, Yurika MIYOSHI, Reiko KOGA, Masashi MITA, Ryuichi KONNO, Kenji HAMASE, Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2015.05.013, 116, 47-52, 2015.05.
64. Sachise KARAKAWA, Kazutaka SHIMBO, Naoyuki YAMADA, Toshimi MIZUKOSHI, Hiroshi MIYANO, Masashi MITA, Wolfgang LINDNER, Kenji HAMASE, Simultaneous analysis of D-alanine, D-aspartic acid, and D-serine using chiral high-performance liquid chromatography-tandem mass spectrometry and its application to the rat plasma and tissues, Journal of Pharmaceutical and Biomedical Analysis, 10.1016/j.jpba.2015.05.024, 115, 123-129, 2015.05.
65. Masataka SUZUKI, Jumpei SASABE, Yurika MIYOSHI, Kenji HAMASE, Masaaki MATSUOKA, Nobuaki IMANISHI, Sadakazu AISO, Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes, Proceedings of the National Academy of Sciences of the United States of America, 10.1073/pnas.1416117112, 112, E2217-E2224, 2015.04.
66. Takato ABE, Masataka SUZUKI, Jumpei SASABE, Shinichi TAKAHASHI, Miyuki UNEKAWA, Kyoko MASHIMA, Takuya IIZUMI, Kenji HAMASE, Ryuichi KONNO, Sadakazu AISO, Norihiro SUZUKI, Cellular origin and regulation of D- and L-serine in in vitro and in vivo models of cerebral ischemia, Journal of Cerebral Blood Flow and Metabolism, 10.1038/jcbfm.2014.164, 34, 1928-1935, 2015.03.
67. Printip WONGTHAI, Kohei HAGIWARA, Yurika MIYOSHI, Pattama WIRIYASERMKUL, Ling WEI, Ryuichi OHGAKI, Itsuro KATO, Kenji HAMASE, Shushi NAGAMORI, Yoshikatsu KANAI, Boronophenylalanine, a boron delivery agent for boron neutron capture therapy, is transported by ATB0,+, LAT1 and LAT2, Cancer Science,, 10.1111/cas.12602, 106, 279-286, 2015.03.
68. Hiroshi HAMAMOTO, Makoto URAI, Kenichi ISHII, Jyunichiro YASUKAWA, Atmika PAUDEL, Motoki MURAI, Takuya KAJI, Takefumi KURANAGA, Kenji Hamase, Takashi KATSU, Jie SU, Tatsuo ADACHI, Ryuji UCHIDA, Hiroshi TOMODA, Maki YAMADA, Manabu SOUMA, Hiroki KURIHARA, Masayuki INOUE, Kazuhisa SEKIMIZU, Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane, Nature Chemical Biology, 10.1038/nchembio.1710, 11, 2, 127-133, 2015.02, 東京大学大学院薬学研究科の関水教授らとの共同研究で様々なD-アミノ酸を含有するユニークな新規抗菌ペプチドを発見した。カイコに黄色ブドウ球菌を感染させた効率的アッセイ系を利用して、これまでに例のない構造と作用機序を有するペプチド「ライソシンE」を発見したもので、新規抗菌剤として臨床利用が期待される。.
69. Kenji HAMASE, Yusuke NAKAUCHI, Yurika MIYOSHI, Reiko KOGA, Nao KUSANO, Hirohisa ONIGAHARA, Hiroshi NARAOKA, Hajime MITA, Yasuhiko KADOTA, Yasuhiro NISHIO, Masashi MITA, Wolfgang LINDNER, Enantioselective determination of extraterrestrial amino acids using a two-dimensional chiral high-performance liquid chromatographic system, Chromatography, 10.15583/jpchom.2014.014, 35, 103-110, 2014.07.
70. Ran INOUE, Yoko YOSHIHISA, Yosuke TOJO, Chieko Okamura, Yuzo YOSHIDA, Jiro KISHIMOTO, Xinghua LUAN, Masahiko WATANABE, Mineyuki MIZUGUCHI, Yuko NABESHIMA, Kenji Hamase, Kenji MATSUNAGA, Tadamichi SHIMIZU, Hisashi MORI, Localization of serine racemase and its role in the skin, Journal of Investigative Dermatology, 10.1038/jid.2014.22, 134, 1618-1626 , 1618-1626, 2014.02.
71. Jumpei Sasabe, Masataka Suzuki, Yurika Miyoshi, Yosuke Tojo, Chieko Okamura, Sonomi Ito, Ryuichi Konno, Masashi Mita, Kenji Hamase, Sadakazu Aiso, Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: early detection of renal dysfunction using the ratio of serine enantiomers, PLOS ONE, 10.1371/journal.phone.0086504, 9, e86504, 2014.01.
72. Yurika MIYOSHI, Masanobu NAGANO, Shoto ISHIGO, Yusuke ITO, Kazunori HASHIGUCHI, Naoto HISHIDA, Masashi MITA, Wolfgang LINDNER, Kenji Hamase, Chiral amino acid analysis of Japanese traditional Kurozu and the developmental changes during earthenware jar fermentation processes, Journal of Chromatography B, 10.1016/j.jchromb.2014.01.034, 966, 187-192, 187-192, 2014.01.
73. Sachise KARAKAWA, Yurika MIYOSHI, Ryuichi KONNO, Satoru KOYANAGI, Masashi MITA, shigehiro OHDO, Kenji HAMASE, Two-dimensional high -performance liquid chromatographic determination of day-night variation of D-alanine in mammals and factors controlling the circadian changes, Analytical and Bioanalytical Chemistry, 10.1007/s00216-013-7071-2, 403, 8083-8091, 2013.10.
74. Yurika Miyoshi, Ryuichi Konno, Jumpei Sasabe, Kyoko Ueno, Yosuke Tojo, Masashi Mita, Sadakazu Aiso, Kenji Hamase, Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase, Amino Acids, 10.1007/s00726-012-1398-4, 43, 1919-1931, 2012.08.
75. Reiko Koga, Yurika Miyoshi, Eiichi Negishi, Tsuneaki Kaneko, Masashi Mita, Wolfgang Lindner, Kenji Hamase, Enantioselective two-dimensional high-performance liquid chromatographic determination of N-methyl-D-aspartic acid and its analogues in mammals and bivalves, Journal of Chromatography A, 10.1016/j.chroma.2012.08.075, 1269, 255-261, 2012.08.
76. Masataka SUZUKI, Jumpei SASABE, Shigeki FURUYA, Masashi MITA, Kenji HAMASE, Sadakazu AISO, Type 1 diabetes mellitus in mice increases hippocampal 1 D-serine in the acute phase after streptozotocin injection, Brain Research, 2012.06.
77. H. NARAOKA, H. MITA, K. HAMASE, M. MITA, H. YABUTA, K. SAITO, K. FUKUSHIMA, F. KITAJIMA, S. A. SANDFORD, T. NAKAMURA, T. NOGUCHI, R. OKAZAKI, K. NAGAO, M. EBIHARA, H. YURIMOTO, A. TSUCHIYAMA, M. ABE, K. SHIRAI, M. UENO, T. YADA, Y. ISHIBASHI, T. OKADA, A. FUJIMURA, T. MUKAI, M. YOSHIKAWA, J. KAWAGUCHI, Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission, Geochemical Journal, 46, 61-72, 2012.01.
78. Jumpei SASABE, Yurika MIYOSHI, Masataka SUZUKI, Masashi MITA, Ryuichi KONNO, Masaaki MATSUOKA, Kenji HAMASE, Sadakazu AISO, D-Amino acid oxidase controls motoneuron degeneration through D-serine, Proceedings of the National Academy of Sciences of the United States of America, 109, 627-632, 2012.01, 難病の一つである筋委縮性側索硬化症(ALS)について、本疾患の発症にD-アミノ酸酸化酵素の活性低下が原因の一つであり、それに依存して脊髄中のD-セリンが特異的に上昇することを明らかにした。この知見により、ALSの診断や治療への新たな道筋が示された。.
79. Hai HAN, Yurika MIYOSHI, Tsubasa OYAMA, Ryoko KONISHI, Masashi MITA, Kenji HAMASE, Enantioselective micro-2D-HPLC determination of aspartic acid in the pineal glands of rodents with various melatonin contents, Journal of Separation Science, 34, 2847-2853, 2011.12.
80. Yurika MIYOSHI, Kenji HAMASE, Tadashi OKAMURA, Ryuichi KONNO, Noriyuki KASAI, Yosuke TOJO, Kiyoshi ZAITSU,, Simultaneous two-dimensional HPLC determination of free D-serine and D-alanine in the brain and periphery of mutant rats lacking D-amino-acid oxidase, Journal of Chromatography B, 879, 3184-3189, 2011.11.
81. Hai HAN, Yurika MIYOSHI, Kyoko UENO, Chieko OKAMURA, Yosuke TOJO, Masashi MITA, Wolfgang LINDNER, Kiyoshi ZAITSU, Kenji HAMASE, Simultaneous determination of D-aspartic acid and D-glutamic acid in rat tissues and physiological fluids using a multi-loop two-dimensional HPLC procedure, Journal of Chromatography B, 879, 3196-3202, 2011.11.
82. Naoko YOSHIKAWA, Waka ASHIDA, Kenji HAMASE, Hiroki ABE, HPLC determination of the distribution of D-amino acids and effects of ecdysis on alanine racemase activity in kuruma prawn Marsupenaeus japonicus, Journal of Chromatography B, 879, 3283-3288, 2011.11.
83. Wataru KAKEGAWA, Yurika MIYOSHI, Kenji HAMASE, Shinji MATSUDA, Keiko MATSUDA, Kazuhisa KOHDA, Kyoichi EMI, Junko MOTOHASHI, Ryuichi KONNO, Kiyoshi ZAITSU, Michisuke YUZAKI, D-Serine regulates cerebellar LTD and motor coordination through the d2 glutamate receptor, Nature Neuroscience, 14, 603-611, 2011.04, これまで世界中で疑問に持たれていた小脳中に幼少期にのみ存在するD-セリンが、運動記憶の獲得に必須の役割を果たすことを明らかにした。この知見により、幼少期に運動記憶が効率的に行われること、また成長後においてもリハビリテーションなどでD-セリンが有用であることを示した。.
84. Jung Hoon YANG, Akira WADA, Kazuyuki YOSHIDA, Yurika MIYOSHI, Tomoko SAYANO, Kayoko ESAKI, Masami O. KINOSHITA, Shozo TOMONAGA, Norihiro AZUMA, Masahiko WATANABE, Kenji HAMASE, Kiyoshi ZAITSU, Takeo MACHIDA, Albee MESSING, Shigeyoshi ITOHARA, Yoshio HIRABAYASHI, Shigeki FURUYA, Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain, The Journal of Biological Chemistry, 285, 41380-41390, 2010.12.
85. Akihiko YAMAGISHI, Shin-ichi YOKOBORI, Yoshitaka YOSHIMURA, Masamichi YAMASHITA, Hirofumi HASHIMOTO, Takashi KUBOTA, Hajime YANO, Junichi HARUYAMA, Makoto TABATA, Kensei KOBAYASHI, Hajime HONDA, Yuichi UTSUMI, Tsunemasa SAIKI, Takashi ITOH, Atsuo MIYAKAWA, Kenji HAMASE, Takeshi NAGANUMA, Hajime MITA, Kenichi TONOKURA, Sho SASAKI, Hideaki MIYAMOTO, Japan Astrobiology Mars Project (JAMP): Search for microbes on the Mars surface with special interest in methane-oxidizing bacteria, Biological Sciences in Space, 24, 67-82, 2010.10.
86. Junzo HIRANO, Kenji HAMASE, Hiroyuki MIYATA and Kiyoshi ZAITSU, 6,7-Difluoro-1,4-dihydro-1-methyl-4-oxo-3-quinolinecarboxylic acid, a newly designed fluorescence enhancement-type derivatizing reagent for amino compounds, Journal of Fluorescence, 20, 615, 2010.03.
87. Kenji HAMASE, Yurika MIYOSHI, Kyoko UENO, Hai HAN, Junzo HIRANO, Akiko MORIKAWA, Masashi MITA, Tsuneaki KANEKO, Wolfgang LINDNER and Kiyoshi ZAITSU, Simultaneous determination of hydrophilic amino acid enantiomers in mammalian tissues and physiological fluids applying a fully automated micro-two-dimensional high-performance liquid chromatographic concept, Journal of Chromatography A, 1217, 1056-1062, 2010.02.
88. Yurika MIYOSHI, Kenji HAMASE, Yosuke TOJO, Masashi MITA, Ryuichi KONNO and Kiyoshi ZAITSU, Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection, Journal of Chromatography B, 877, 2506-2512, 2009.08.
89. Yosuke TOJO, Kenji HAMASE, Ryuichi KONNO, Satoru KOYANAGI, Shigehiro OHDO and Kiyoshi ZAITSU, Simple and rapid genotyping of D-amino acid oxdase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis, Journal of Separation Science, 32, 430-436, 2009.02.
90. Sachise ETOH, Kenji HAMASE, Akiko MORIKAWA, Tomohiro OHGUSU and Kiyoshi ZAITSU, Enantioselective visualization of D-alanine in rat anterior pituitary gland: localization to ACTH-secreting cells, Analytical and Bioanalytical Chemistry, 393, 217-223., 2009.01.
91. Akiko MORIKAWA, Kenji HAMASE, Yurika MIYOSHI, Satoru KOYANAGI, Shigehiro OHDO and Kiyoshi ZAITSU, Circadian changes of D-alanine and related compounds in rats and the effect of restricted feeding on their amounts, Journal of Chromatography B, 875, 168-173., 2008.11.
92. Yosuke TOJO, Kenji HAMASE, Minako NAKATA, Akiko MORIKAWA, Masashi MITA, Yutaka ASHIDA, Wolfgang LINDNER and Kiyoshi ZAITSU, Automated and simultaneous two-dimensional micro-high-performance liquid chromatographic determination of proline and hydroxyproline enantiomers in mammals, Journal of Chromatography B, 875, 174-179., 2008.11.
93. Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU, Structural and photophysical properties of novel dual fluorescent compounds, 1-aryl-substituted 6-methoxy-4-quinolones, Luminescence, 23, 350-355., 2008.10.
94. Junzo HIRANO, Hiroyuki MIYATA, Kenji HAMASE and Kiyoshi ZAITSU, A ratiometric fluorescent chemosensor, 1,10-phenanthroline-4,7-dione, for anions in aqueous-organic media, Tetrahedron Letters, 48(28), 4861-4864, 2007.07.
95. Yukitaka MORITA, Hiroshi UJIKE, Yuji TANAKA, Kyohei OTANI, Makiko KISHIMOTO, Akiko MORIO, Tatsuya KOTAKA, Yuko OKAHISA, Masayuki MATSUSHITA, Akiko MORIKAWA, Kenji HAMASE, Kiyoshi ZAITSU and Shigetoshi KURODA, A genetic variant of the serine racemase gene is associated with schizophrenia, Biological Psychiatry, 61(10), 1200-1203 , 2007.05.
96. Akiko MORIKAWA, Kenji HAMASE, Tomohiro OHGUSU, Sachise ETOH, Hiroyuki TANAKA, Ichiro KOSHIISHI, Yukihiro SHOYAMA and Kiyoshi ZAITSU, Immunohistochemical localization of D-alanine to β-cells in rat pancreas, Biochemical and Biophysical Research Communications, 355, 872-876, 2007.04.
97. Kenji HAMASE, Akiko MORIKAWA, Tomohiro OHGUSU, Wolfgang LINDNER and Kiyoshi ZAITSU, Comprehensive analysis of branched aliphatic D-amino acids in mammals using an integrated multi-loop two-dimensional column-switching high-performance liquid chromatographic system combining reversed-phase and enantioselective columns, Journal of Chromatography A, 1143, 105-111, 2007.03.
98. Akiko MORIKAWA, Kenji HAMASE, Tomomi INOUE, Ryuichi KONNO and Kiyoshi ZAITSU, Alteration in D-Amino Acid Levels in the Brains of Mice and Rats After the Administration of D-Amino Acids, Amino Acids, 32, 13-20, 2007.01.
99. Tomohiro OHGUSU, Kenji HAMASE, Hiroyuki TANAKA, Yukihiro SHOYAMA, and Kiyoshi ZAITSU, High-throughput determination of free D-aspartic acid in mammals by enzyme immunoassay using apecific monoclonal antibody, Analytical Biochemistry, 357, 15-20, 2006.10.
100. Junzo HIRANO, Kenji HAMASE, and Kiyoshi ZAITSU, Evaluation of a simple and novel fluorescent anion sensor,4-quinolone,and modification of the emission color by substitutions based on molecular orbital calculations, Tetrahedron, 62, 10065-10071, 2006.10.
101. Kenji HAMASE, Sayaka TAKAGI, Akiko MORIKAWA, Ryuichi KONNO, Akira NIWA, and Kiyoshi ZAITSU, Presence and origin of large amounts of D-proline in the urine of mutant mice lacking D-amino acid oxidase activity, Analytical and Bioanalytical Chemistry, 386, 705-711, 2006.10.
102. Kenji HAMASE, Reiko NAGAYASU, Akiko MORIKAWA, Ryuichi KONNO and Kiyoshi ZAITSU, Sensitive High-Performance Liquid Chromatographic Assay for D-Amino-Acid Oxidase Activity in Mammalian Tissues using a Fluorescent Non-Natural Substrate, 5-Fluoro-D-Tryptophan, Journal of Chromatography A, 1106, 159-164, 2006.02.
103. Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU, Crystal Structure of 6-Methoxy-4-quinolone, C10H9NO2・2H2O, Analytical Sciences, 21, x45-x46, 2005.01.
104. Junzo HIRANO, Kenji HAMASE, Hiroko FUKUDA, Tatsunosuke TOMITA and Kiyoshi ZAITSU, Novel stable fluorophore, 6-methoxy-4-quinolone, with strong fluorescence in wide pH range of aqueous media, and its application as a fluorescent labeling reagent, Journal of Chromatography A, 10.1016/j.chroma.2004.10.020, 1059, 1-2, 225-231, 1059, 225-231, 2004.12.
105. Kenji HAMASE, Junzo HIRANO, Yuki KOSAI, Tatsunosuke TOMITA and Kiyoshi ZAITSU, A Sensitive Internal Standard Method for the Determination of Melatonin in Mammals using Precolumn Oxidation Reversed-Phase High-Performance Liquid Chromatography, Journal of Chromatography B, 10.1016/j.jchromb.2004.08.027, 811, 2, 237-241, 811, 237-241, 2004.11.
106. Hua ZHAO, Kenji HAMASE, Akiko MORIKAWA, Zongyin Qiu and Kiyoshi ZAITSU, Determination of D- and L-Enantiomers of Threonine and allo-Threonine in Mammals using Two-Step High-Performance Liquid Chromatography, Journal of Chromatography B, 10.1016/j.jchromb.2004.08.006, 810, 2, 245-250, 810, 245-250, 2004.10.
107. Junzo HIRANO, Kenji HAMASE, Takeyuki AKITA and Kiyoshi ZAITSU, Crystal Structure of N-[(6-Methoxy-4-oxo-1,4-dihydroquinolin-3-yl)methyl]-2,2-dimethylpropanamide, Analytical Sciences, 20, x115-x116, 2004.09.
108. Takanori AKAGI, Kazami USHINOHAMA, Shoko IKESUE, Eiji YUKAWA, Shun HIGUCHI, Kenji HAMASE, Kiyoshi ZAITSU and Shigehiro OHDO, Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect, The Journal of Pharmacology and Experimental Therapeutics, 10.1124/jpet.103.055657, 308, 1, 378-384, 308, 378-384, 2004.01.
109. Koji YAMAMOTO, Kenji HAMASE and Kiyoshi ZAITSU, 2-Amino-3-phenylpyrazine, a Sensitive Fluorescence Prelabeling Reagent for the Chromatographic or Electrophoretic Determination of Saccharides, Journal of Chromatography A, 10.1016/S0021-9673(03)00452-7, 1004, 1-2, 99-106, 1004, 99-106, 2003.07.
110. Tatsunosuke TOMITA, Kenji HAMASE, Hiromi HAYASHI, Hiroko FUKUDA, Junzo HIRANO and Kiyoshi ZAITSU, Determination of Endogenous Melatonin in the Individual Pineal Glands of Inbred Mice using Precolumn Oxidation Reversed-Phase Micro-High-Performance Liquid Chromatography, Analytical Biochemistry, 10.1016/S0003-2697(03)00079-4, 316, 2, 154-161, 316, 154-161, 2003.05.
111. Akiko MORIKAWA, Kenji HAMASE and Kiyoshi ZAITSU, Determination of D-Alanine in the Rat Central Nervous System and Periphery using Column-Switching High-Performance Liquid Chromatography, Analytical Biochemistry, 10.1016/S0003-2697(02)00432-3, 312, 1, 66-72, 312, 66-72, 2003.01.
112. Kayo SAKATA, Kenji HAMASE and Kiyoshi ZAITSU, Reversible Fluorescence Labeling of Amino Groups of Protein using Dansylaminomethylmaleic Anhydride, Journal of Chromatography B, 10.1016/S1570-0232(01)00629-8, 769, 1, 47-54, 769, 47-54, 2002.03.
113. Kenji HAMASE, Tomomi INOUE, Akiko MORIKAWA, Ryuichi KONNO and Kiyoshi ZAITSU, Determination of Free D-Proline and D-Leucine in the Brains of Mutant Mice Lacking D-Amino-Acid Oxidase Activity, Analytical Biochemistry, 10.1006/abio.2001.5382, 298, 2, 253-258, 298, 253-258, 2001.11.
114. Akiko MORIKAWA, Kenji HAMASE, Tomomi INOUE, Ryuichi KONNO, Akira NIWA and Kiyoshi ZAITSU, Determination of Free D-Aspartic Acid, D-Serine and D-Alanine in the Brain of Mutant Mice Lacking D-Amino-Acid Oxidase Activity, Journal of Chromatography B, 10.1016/S0378-4347(01)00131-1, 757, 1, 119-125, 757, 119-125, 2001.06.
115. Tatsunosuke TOMITA, Kenji HAMASE, Hiromi HAYASHI and Kiyoshi ZAITSU, Attomole analysis of melatonin by precolumn derivatization reversed-phase micro-HPLC, Chromatography, 22(1), 41-44, 2001.01.
116. Wei WU, Kenji HAMASE, Masaru KIGUCHI, Koji YAMAMOTO and Kiyoshi ZAITSU, Reversed-phase HPLC of monosaccharides in glycoproteins derivatized with aminopyrazine with fluorescence detection, Analytical Sciences, 10.2116/analsci.16.919, 16, 9, 919-922, 16(9), 919-922 , 2000.09.
117. Tomomi INOUE, Kenji HAMASE, Akiko MORIKAWA and Kiyoshi ZAITSU, Determination of Minute Amounts of D-Leucine in Various Brain Regions of Rat and Mouse Using Column-Switching High-Performance Liquid Chromatography, Journal of Chromatography B, 10.1016/S0378-4347(00)00244-9, 744, 1, 213-219, 744, 213-219, 2000.07.
118. Yoshihito OHBA, Naomi KOTO, Kenji HAMASE and Kiyoshi ZAITSU, Non-acidic matrix for the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of acidic-labile compounds, Analytical Sciences, 10.2116/analsci.16.659, 16, 6, 659-661, 16(6), 659-661 , 2000.06.
119. Kenji HAMASE, Keizo IWASHITA and Kiyoshi ZAITSU, Selective masking of amino groups during fluorescence derivatization in the presence of a molecular imprint polymer , Analytical Sciences, 10.2116/analsci.16.417, 16, 4, 417-419, 16(4), 417-419 , 2000.04.
120. Kenji HAMASE, Tatsunosuke TOMITA, Ayako KIYOMIZU and Kiyoshi ZAITSU, Determination of pineal melatonin by precolumn derivatization reversed-phase high-performance liquid chromatography and its application to the study of circadian rhythm in rats and mice, Analytical Biochemistry, 10.1006/abio.1999.4435, 279, 1, 106-110, 279(1), 106-110 , 2000.03.
121. Kenji HAMASE, Tatsunosuke TOMITA, Ayako KIYOMIZU and Kiyoshi ZAITSU, Determination of Pineal Melatonin by Precolumn Derivatization Reversed-Phase High Performance Liquid Chromatography and Its Application to the Study of Circadian Rhythm in Rats and Mice, Analytical Biochemistry, 10.1006/abio.1999.4435, 279, 1, 106-110, 279, 106-110, 2000.01.
122. Kayo SAKATA, Kenji HAMASE, Shigeki SASAKI, Minoru MAEDA and Kiyoshi ZAITSU, Reversible fluorescence derivatization of amino groups using dansylaminomethylmaleic acid via its anhydride, Analytical Sciences, 10.2116/analsci.15.1095, 15, 11, 1095-1099, 15(11), 1095-1099 , 1999.11.
123. Masaru KIGUCHI, Kenji HAMASE, Wei WU, Koji YAMAMOTO and Kiyoshi ZAITSU, Sensitive anion-exchange HPLC of aminopyrazine derivatives of saccharides having n-acetylated monosaccharide at the reducing end, Analytical Sciences, 10.2116/analsci.15.903, 15, 9, 903-905, 15(9), 903-905 , 1999.09.
124. Kenji HAMASE, Hiroshi HOMMA, Yuki TAKIGAWA and Kazuhiro IMAI, Alteration in the D-amino acid content of the rat pineal gland under anesthesia, Amino Acids, 10.1007/BF01366926, 17, 3, 277-283, 17(3), 277-283 , 1999.09.
125. Kiyoshi ZAITSU, Yoshitada KIMURA, Yoshihito OHBA, Kenji HAMASE, Yuji MOTOMURA, Minoru ITOSE and Masato ISHIYAMA, Heme-undecapeptide labeling on insulin for the immunoassay of insulin with chemiluminescence detection, Analytical Sciences, 10.2116/analsci.15.871, 15, 9, 871-878, 15(9), 871-878 , 1999.09.
126. Kenji HAMASE, Keizo IWASHITA and Kiyoshi ZAITSU, Enantio-selective derivatization of amino compounds in the presence of a molecular imprint polymer, Analytical Sciences, 10.2116/analsci.15.411, 15, 5, 411-412, 15(5), 411-412 , 1999.05.
127. Shoko TANIGICHI, Kenji HAMASE, Akio KINOSHITA and Kiyoshi ZAITSU, Simple and rapid analytical method for carbapenems using capillary zone electrophoresis, Journal of Chromatography B, 10.1016/S0378-4347(99)00005-5, 727, 1-2, 219-225, 727(1-2), 219-225 , 1999.04.
128. Fumio IINUMA, Kenji HAMASE, Sayaka MATSUBAYASHI, Masaki TAKAHASHI, Mitsuo WATANABE and Kiyoshi ZAITSU, Sensitive determination of melatonin by precolumn derivatization and reversed-phase high-performance liquid chromatography, Journal of Chromatography A, 10.1016/S0021-9673(99)00041-2, 835, 1-2, 67-72, 835(1-2), 67-72 , 1999.03.
129. Kazuaki TACHIKI, Hideyuki YOSHIDA, Kenji HAMASE and Kiyoshi ZAITSU, Aminopyrazine as a precolumn derivatizing reagent for fluorescence detection of monosaccharides in high-performance liquid chromatography, Analytical Sciences, 10.2116/analsci.13.509, 13, 3, 509-512, 13(3), 509-512 , 1997.06.
130. Kenji HAMASE, Hiroshi HOMMA, Yuki TAKIGAWA, Takeshi FUKUSHIMA, Tomofumi SANTA and Kazuhiro IMAI, Regional distribution and postnatal changes of D-amino acids in rat brain, Biochimica et Biophysica Acta, 1334(2-3), 214-222, 1997.04.
131. Kenji HAMASE and Hiroshi NAKAMURA, A simple method for high recovery of proteins after sodium dodecyl sulfate curdlan gel electrophoresis, Analytical Sciences, 12(3), 489-490 , 1996.06.
132. Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA, Curdlan gel as a bioinert support for the electrophoresis of biologically active proteins, Analytical Sciences, 12(2), 273-275 , 1996.04.
133. Hikoya HAYATSU, Takeshi NAWAMURA, Takashi KUBO, Kazuo NEGISHI, Ryoya GOHDA, Kenji HAMASE and Kazuhiro Imai, A fluorescent derivative of 4-thiouridine, Nucleic Acids Symposium Series, 31, 33-34, 1994.01.
134. Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA, Curdlan gel, evaluated as a polysaccharide support by electrophoresis of substituted benzenes, Analytical Sciences, 9(6), 799-802 , 1993.12.
135. Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA, Group separation of linear DNAs and circular DNAs by curdlan gel electrophoresis, Analytical Sciences, 9(1), 125-127 , 1993.02.
136. Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA, Sodium dodecyl sulfate curdlan gel electrophoresis system for proteins, Analytical Sciences, 8(5), 699-700 , 1992.10.
137. Kenji HAMASE, Hiroshi NAKAMURA and Terumi NAKAJIMA, Curdlan gel as a promising support for electrophoresis, Analytical Sciences, 7(5), 811-812, 1991.10.