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Hirofumi Tachibana Last modified date:2024.02.02

Professor / Food science and technology
Department of Bioscience and Biotechnology
Faculty of Agriculture

Graduate School
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Academic Degree
Ph.D (Agriculture)
Field of Specialization
Food chemicalbiology, Food function regulation technology, lifescience, Antibogy engineering
Outline Activities
Identification of molecular targets for phytochemicals
Green tea polyphenol receptor: Structure and Function
Research Interests
  • Identification of food factors for prevention of life style-relating diseases.
    keyword : Food factors, life style-relating diseases
  • Food chemical biology
    keyword : Food chemical biology
  • Identification and application of the molecular targets of functional food factors

    keyword : target molecule, green tea, signaling
    1998.04Molecular characterization of green tea polyphenol receptor and its function.
  • Elucidation of Sensory Systems for Food Factors in View of Molecular Epidemiology

    keyword : epidemiology, target molecule, green tea, signaling
    2010.04Molecular characterization of green tea polyphenol receptor and its function.
  • Identification and apllication of the genes that are responsible to life style-relating diseases
    keyword : diabeties, adiponectin receptor, lipogenesis
    1997.04Identification and apllication of the genes that are responsible to life style-relating diseases.
  • Identification and application of anti-allergy factors in foods
    keyword : anti-allergy foods, methylated catechin, strictinin, IgE, FceRI, lipid raft, STAT6, IL-4
    1998.04Identification of anti-allergy factors in foods for generation of anti-allergy foods.
  • Genaration of functional antibodies
    keyword : abzyme, protease, antigen
    1997.04Generation of antibody-based tailormaid proteases.
Current and Past Project
  • Generation of anti-allergy foods by using anti-allergic tea components
    This project is supported grant from Bio-oriented technology research advancement institution (BRAIN).
  • Study on physiological functions of food componebts
    This project is supported grant from Integrated research on safety and physiological function of food, MAFF.
  • Identification and charactrization of anti-allergic components from tea
    This project is supported grant from Bio-oriented technology research advancement institution (BRAIN).
Academic Activities
1. Fujimura Y, Hirofumi Tachibana, Metabolomics of Green Tea, GENOMICS, PROTEOMICS AND METABOLOMICS IN NUTRACEUTICALS & FUNCTIONAL FOODS (2nd Ed), Ed by Debasis Bagchi, Anand Swaroop, Manashi Bagchi

, John Wiley & Sons, pp397-406 (2015), 2015.09.
2. Hirofumi Tachibana, Scientific Evidence for the Health Benefits of Green Tea, Japan Tea Central Public Interest Incorporated Association, pp45-57; pp111-117, 2015.09.
3. Maeda-Yamamoto, M., Hirofumi Tachibana, Sameshima, Y., Kuriyama, S., Tea in Health and Disease Prevention, Taylor & Trancis, 115-125
, 2012.12.
4. Byun, E-H., Hirofumi Tachibana, Tea in Health and Disease Prevention, Taylor & Trancis, 1239-1248
, 2012.12.
5. 立花宏文, Green Tea Polyphenols: Nutraceuticals of Modern Life, Taylor & Trancis, 2011.10.
6. Fujimura, Y., and Tachibana, H., Molecular basis for the anti-cancer activity of EGCG in vivo: Molecular-targeting prevention of cancer by green tea catechin., Green Tea and Health Research
, Nova Publishers , 257-299, 2009.05.
7. Tachibana, H., Food Factors for Health Promotion, Forum Nutr. , Vol. 61, 156-169, 2009.05.
8. Tachibana H, Research Focus on Natural products and the Body's Immune and Inflammatory , Nova Publisher, 169-187 , 2007.12.
1. Yoshinori Fujimura, Motofumi Kumazoe, Hirofumi Tachibana, 67‐kDa Laminin Receptor‐Mediated Cellular Sensing System of Green Tea Polyphenol EGCG and Functional Food Pairing, Molecules,, 2022.08.
2. Motofumi Kumazoe, Yoshinori Fujimura, Hirofumi Tachibana, 67-kDa Laminin Receptor Mediates the Beneficial Effects of Green Tea Polyphenol EGCG, Current Pharmacology Reports, 10.1007/s40495-020-00228-3, 2020.09.
3. Yoshinori Fujimura, Daisuke Miura, and Hirofumi Tachibana, A Phytochemical-Sensing Strategy Based on Mass Spectrometry Imaging and Metabolic Profiling for Understanding the Functionality of the Medicinal Herb Green Tea, Molecules. 22(10). pii: E1621., 10.3390/molecules22101621., 2017.07.
4. Motofumi Kumazoe, 立花 宏文, Anti-cancer effect of EGCG and its mechanisms, Functional Foods in Health and Disease, 6(1), 70-78 (2016), 2015.07.
5. 立花 宏文, 緑茶カテキンによって誘導される新たな骨髄腫細胞の細胞死誘導経路, 血液内科, 2015.02.
6. 立花 宏文, Cellular sensing system for green tea polyphenol epigallocatechin gallate, AGgri-Bioscience Monographs, 2014.07.
7. 立花宏文, Green tea polyphenol sensing, The Proceedings of the Japan Academy, Series B, 2011.03.
1. Kwanwoo Lee,Motofumi Kumazoe,Yuki Marugame,Yoshinori Fujimura, andHirofumi Tachibana, Dextran sulfate sodium-induced mild chronic colitis induced cognitive impairment accompanied by inhibition of neuronal maturation in adolescent mice, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2023.05.112, 669, 46-53, 2023.06.
2. Motofumi Kumazoe,Fumiyo Ogawa,Ai Hikida,Yu Shimada,Ren Yoshitomi,Ryoya Watanabe,Yoshinori Fujimura, andHirofumi Tachibana, Plant miRNA osa-miR172d-5p suppressed lung fibrosis by targeting Tab1, Sci. Rep., Doi: 10.1038/s41598-023-29188-6, 13, 2128, 2023.02.
3. Motoki Murata,Yuki Marugame,Mai Morozumi,Kyosuke Murata,Motofumi Kumazoe,Yoshinori Fujimura, andHirofumi Tachibana, (-)-Epigallocatechin-3-O-gallate upregulated the expression levels of miR-6757-3p, a suppressor of fibrosis-related gene expression, in extracellular vesicles derived from human umbilical vein endothelial cells, Biomedical Reports, doi: 10.3892/br.2023.1601, 18, 19, 2023.01.
4. Motoki Murata,Satomi Komatsu,Emi Miyamoto,Chihiro Oka,Ichian Lin,Motofumi Kumazoe,Shuya Yamashita,Yoshinori Fujimura, and Hirofumi Tachibana, Quercetin up-regulates the expression of tumor-suppressive miRNAs in human cervical cancer, Bioscience of Microbiota, Food and Health, 42, 87-93, 2023.01.
5. Yoshinori Fujimura,Takanori Yoshimoto,Konatsu Fujino,Ayaka Nezu,Yuki Marugame,Jaehoon Bae,Motofumi Kumazoe, andHirofumi Tachibana, Bioactivity-boosting strategy based on combination of anti-allergic O-methylated catechin with a Citrus flavanone, hesperetin

, J. Nat. Med., doi: 10.1007/s11418-022-01668-5, 77, 363-369, 2022.12.
6. Jaehoon Bae,Kwanwoo Lee,Ji Sun Park,Jinseok Jung,Hirofumi Tachibana,Yoshinori Fujimura,Motofumi Kumazoe,Jae Sung Lim,Young-Chang Cho,Seung-Jae Lee and Su-Jin Park , Phosphodiesterase 5 Inhibitor Potentiates Epigallocatechin 3-O-Gallate-Induced Apoptotic Cell Death via Activation of the cGMP Signaling Pathway in Caco-2 Cells, Curr. Issues Mol. Biol. , doi: 10.3390/cimb44120426, 44, 6247-6256, 2022.12.
7. @Tomomi Morikawa-Ichinose,@Yoshinori Fujimura,@Motofumi Kumazoe,@Hiroaki Onda,@Daisuke Miura,@Hirofumi Tachibana, Inflammatory markers S100A8/A9 and metabolic alteration for evaluating signs of early phase toxicity of anticancer agent treatment

, Food and Chemical Toxicology, doi: 10.1016/j.fct.2022.113421, 169, 113421, 2022.09.
8. @Motoki Murata,#Yuki Marugame,@Shuhei Yamada,@I-Chian Lin,@Shuya Yamashita,@Yoshinori Fujimura, and@Hirofumi Tachibana, Circulating miRNA profiles in mice plasma following flavonoid intake, Mol. Biol. Rep., doi: 10.1007/s11033-022-07918-9, 49, 10399-10407, 2022.09.
9. @Daiki Hayashi,@Varnavas D. Mouchlis,@Seika Okamoto,@Liuqing Wang,@Sheng Li,@Shuji Ueda,@Minoru Yamanoue,@Hirofumi Tachibana, @Hiroyuki Arai,@Hitoshi Ashida,@Edward A. Dennis, and@Yasuhito Shirai, Vitamin E Functions by Association with a Novel Binding Site on the 67 kDa Laminin Receptor Activating Diacylglycerol Kinase

, J. Nutr. Biochem, doi:10.1016/j.nutbio.2022.109129, 110, 109129, 2022.12.
10. Yu Shimada,Yuka Sato,Motofumi Kumazoe,Ryo Kitamura,Yoshinori Fujimura, andHirofumi Tachibana, Myricetin improve cognitive function in SAMP8 mice accompanied with upregulation of BDNF and NGF, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2022.05.039, 616, 33-40, 2022.05.
11. Yoshinori Fujimura,Mototsugu Watanabe,Tomomi Morikawa-Ichinose,Konatsu Fujino,Mao Yamamoto,Seita Nishioka,Chihiro Inoue, Fumiyo Ogawa,Madoka Yonekura,Akari Nakasone,Motofumi Kumazoe, andHirofumi Tachibana, Metabolic profiling for evaluating the dipeptidyl peptidase-IV inhibitory potency of diverse green tea cultivars and determining bioactivity-related ingredients and combinations, J. Agri. Food Chem, doi:10.1021/acs.jafc.2c01693, 70, 6455-6466, 2022.05.
12. Motofumi Kumazoe,Yoshinori Fujimura,Ren Yoshitomi,Yu Shimada,and Hirofumi Tachibana, Fustin, a flavanonol, synergically potentiates the anti-cancer effect of the green tea catechin EGCG with activation of the eNOS/cGMP axis, J. Agri. Food Chem, doi: 10.1021/acs.jafc.1c07567, 70, 3458-3466, 2022.02.
13. Motoki Murata,Kai Nakayama,Ryo Kitamura,Megumi Goto,Mai Morozumi,Takanori Yoshimoto,Yuki Marugame,Ren Yoshitomi,Shuya Yamashita,Yoshinori Fujimura, and Hirofumi Tachibana, Japanese soup stocks (katsuo-dashi and kombu-dashi) modulate food factor sensing-related gene expression in mice, Int. J.Gastronomy and Food Science, doi:10.1016/j.ijgfs.2022.100573, 29, 100573, 2022.09.
14. Yuki Marugame,Natsuko Takeshita,Shuhei Yamada,Ren Yoshitomi,Motofumi Kumazoe,Yoshinori Fujimura and Hirofumi Tachibana, Sesame Lignans Upregulate Glutathione S-transferase Expression and Downregulate microRNA-669c-3p, Bioscience of Microbiota, Food and Health, doi: 10.12938/bmfh. 2021-067, 41, 66-72, 2022.01.
15. Shuya Yamashita,Ichian Lin,Chihiro Oka,Motofumi Kumazoe,Satomi Komatsu,Motoki Murata,Shoko Kamachi,andHirofumi Tachibana, Soy isoflavone metabolite equol inhibits cancer cell proliferation in a PAP associated domain containing 5-dependent and an estrogen receptor-independent manner, J. Nutr. Biochem., doi: 10.1016/j.jnutbio.2021.108910., 100, 108910, 2022.02.
16. Motofumi Kumazoe,Kanako Takamatsu,Fuyumi Horie,Ren Yoshitomi,Hiroki Hamagami,Hiroshi Tanaka,Yoshinori Fujimura,Hirofumi Tachibana, Methylated (−)-epigallocatechin 3-O-gallate potentiates split vaccine accompanied with upregulation of Toll-like receptor 5 , Sci. Rep., doi: 10.1038/s41598-021-02346-4., 11, 23101, 2021.11.
17. Ren Yoshitomi, Mao Yamamoto, Motofumi Kumazoe, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Akari Nakasone, Satoshi Kondo, Hiroki Hattori, Akane Haseda, Jun Nishihira, Hirofumi Tachibana, The combined effect of green tea and α-glucosyl hesperidin in preventing obesity:a randomized placebo-controlled clinical trial, Sci. Rep., doi: 10.1038/s41598-021-98612-6., 11, 19067, 2021.09.
18. Akira Iwamoto,Yuichi Inoue,Hirofumi Tachibana,Hiroharu Kawahara, Immunomodulatory effect of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in allergic conditions in vitro and in vivo, Cytotechnology,, 73, 333-342, 2021.06.
19. Motofumi Kumazoe, Yasutake Tanaka, Ren Yoshitomi, Yuki Marugame, Kwan-Woo Lee, Hiroaki Onda, Yoshinori Fujimura, Madoka Yonekura, Yasuyo Shimamoto, Hirofumi Tachibana, Glucosyl-hesperidin enhances the cyclic guanosine monophosphate-inducing effect of a green tea polyphenol EGCG, J. Natural Medicines, doi: 10.1007/s11418-021-01538-6, 75, 1037-1042, 2021.07.
20. Yoshinori Fujimura, Konatsu Fujino, Takanori Yoshimoto, Ayaka Nezu, Yuki Marugame, Jaehoon Bae, Motofumi Kumazoe, Hirofumi Tachibana, Eriodictyol-amplified 67-kDa laminin receptor signaling potentiates the anti-allergic effect of O-methylated catechin, J. Natural Products, doi: 10.1021/acs.jnatprod.1c00337, 84, 1823-1830, 2021.07.
21. Yasutake Tanaka,Motofumi Kumazoe,Hiroaki Onda,Yoshinori Fujimura, andHirofumi Tachibana, Oral EGCG administration time-dependently increases plasma cGMP concentration in mice, Food Bioscience, doi:10.1016/j.fbio.2021.101017, 41, 101017, 2021.06.
22. Ren Yoshitomi,Kai Nakayama,Shuya Yamashita,Motofumi Kumazoe,Ting-An Lin,Chen-Yi Mei,Yuki Marugame,Yoshinori Fujimura,Mari Maeda-Yamamoto,Shinichi Kuriyama, andHirofumi Tachibana, Plasma Homocysteine Concentration is Associated with the Expression Level of Folate Receptor 3, Sci. Rep., doi: 10.1038/s41598-020-67288-9, 10, 1, 10283, 2020.12, 葉酸のホモシステイン代謝促進活性にFolate Receptor 3が重要な役割を担っていることを発見した。.
23. Motoki Murata,Yuki Shimizu,Yuki Marugame,Ayaka Nezu,Konatsu Fujino,Syuhei Yamada,Motofumi Kumazoe,Yoshinori Fujimura, and Hirofumi Tachibana, EGCG down-regulates MuRF1 expression through 67-kDa laminin receptor and the receptor signaling is amplified by eriodictyol, J. Natural Medicines, doi:10.1007/s11418-020-01417-6, 74, 4, 637-679, 2020.05.
24. Motofumi Kumazoe,Mai Kadomatsu,Jaehoon Bae,Yushi Otsuka, Yoshinori Fujimura, and Hirofumi Tachibana, Src mediates epigallocatechin-3-O-gallate-elicited acid, Molecules, doi:10.3390/molecules25225481, 25, 22, 5481, 2020.11.
25. Motofumi Kumazoe, Shun Hiroi, Yousuke Tanimoto, Jyunichi Miyakawa, Maasa Yamanouchi, Yumi Suemasu, Ren Yoshitomi, Motoki Murata, Yoshinori Fujimura, Takashi Takahashi, Hiroshi Tanaka, and Hirofumi Tachibana, Cancer cell selective probe by mimicking EGCG, Biochem. Biophys. Res. Commun., doi:10.1016/j.bbrc.2020.03.021, 525, 974-981, 2020.02.
26. Jaehoon Bae, Motofumi Kumazoe, Kyosuke Murata, Yoshinori Fujimura, and Hirofumi Tachibana, Procyanidin C1 inhibits melanoma cell growth by activating 67-kDa laminin receptor signaling, Molecular Nutrition & Food Research, doi: 10.1002/mnfr.201900986, 64, 1900986, 2020.04, 多彩な生体調節作用を示すプロシアニジンC1の受容体分子として67LRを同定するとともに受容体を介したプロシアニジンC1の生理活性発現メカニズムを明らかにした。.
27. Jaehoon Bae, Motofumi Kumazoe, Chieri Takeuchi, Shiori Hidaka, Yoshinori Fujimura, and Hirofumi Tachibana, Epigallocatechin-3-O-gallate induces acid sphingomyelinase activation through activation of phospholipase C, Biochem. Biophys. Res. Commun., doi: 10.1016/j.bbrc.2019.09.102., 520, 186-191, 2019.04.
28. Akira Iwamoto, Yuichi Inoue, Hirofumi Tachibana, Hiroharu Kawahara, Alkali-soluble pectin suppresses IgE production in human myeloma cell line in vitro, Cytotechnology, 10.1007/s10616-019-00306-5, 71, 2, 573-581, 71(2), 573-58, 2019.04.
29. Jaehoon Bae, Motofumi Kumazoe, Yoshinori Fujimura, and Hirofumi Tachibana, Diallyl disulfide potentiates anti-obesity effect of green tea in high-fat/high-sucrose diet-induced obesity, J. Nutr. Biochem., 64, 152-161, 64, 152-161, 2019.02.
30. Masafumi Wasai, Haruna Nonaka, Motoki Murata, Ryo Kitamura, Yuka Sato, and Hirofumi Tachibana, Long-term dietary supplementation with the green tea cultivar Sunrouge prevents age-related cognitive decline in the senescence-accelerated mouse Prone8, Biosci. Biotechnol. Biochem., 10.1080/09168451.2018.1530093, 83, 339-347, 83, 339-347, 2018.10.
31. Masafumi Wasai, Yoshinori Fujimura, Haruna Nonaka, Ryo Kitamura, Motoki Murata, and Hirofumi Tachibana, Postprandial glycaemia-lowering effect of a green tea cultivar Sunrouge and cultivar-specific metabolic profiling for determining bioactivity-related ingredients, Sci. Rep., 10.1038/s41598-018-34316-8, 8, 16041, 8:16041, 2018.10.
32. Yoshito Abe, Naoki Odawara, Nantanat Aeimhirunkailas, Hinako Shibata, Naoki Fujisaki, Hirofumi Tachibana, Tadashi Ueda, Inhibition of amyloid fibril formation in the variable domain of 6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate, Biochim Biophys Acta Gen. Subj., 10.1016/j.bbagen.2018.08.006., 1862, 2570-2578, 1862, 2570-2578, 2018.08.
33. Masahiro Miyawaki, Hiroyuki Sano, Hisashi Imbe, Reiko Fujisawa, Keiji Tanimoto, Jungo Terasaki, Mari Maeda-Yamamoto, Hirofumi Tachibana, Akihisa Imagawa, Toshiaki Hanafusa, O-Methylated catechins from "Benifuuki" green tea reduce serum levels of lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B: a double-blind placebo-controlled randomized trial, Nutrients, 10.3390/nu10070924, 10, 924, 10, 924, 2018.07.
34. Shuya Yamashita, Asami Hirashima, I-Chian Lin, Jaehoon Bae, Kanami Nakahara, Motoki Murata, Shuhei Yamada, Motofumi Kumazoe, Ren Yoshitomi, Mai Kadomatsu, Yuka Sato, Ayaka Nezu, Ai Hikita, Konatsu Fujino, Kyosuke Murata, Mari Maeda-Yamamoto and Hirofumi Tachibana, Saturated fatty acid inhibits anti-obesity effect of green tea., Sci. Rep., 10.1038/s41598-018-28338-5, 8, 10023, 8:10023, 2018.07.
35. Mari Maeda-Yamamoto , Mie Nishimura, Nobuyoshi Kitaichi, Atsushi Nesumi, Manami Monobe, Sachiko Nomura, Yukihiko Horie, Hirofumi Tachibana, Jun Nishihira, A randomized, placebo-controlled study on the safety and efficacy of daily ingestion of green tea (Camellia sinensis L.) cv. “Yabukita” and “Sunrouge” on eyestrain and blood pressure in healthy adults, Nutrients, 2018, 10, 569; , 10.3390/nu10050569, 2018.02.
36. Hisashi Ohseto, Mami Ishikuro,Masahiro Kikuya,Taku Obara, Yuko Igarashi, Satomi Takahashi, Michiko Shigihara,Chizuru Yamanaka, Masako Miyashita, Satoshi Mizuno, Masato Nagai, Hiroko Matsubara, Yuki Sato, Hirohito Metoki, Hirofumi Tachibana, Mari Maeda-Yamamoto, and Shinichi Kuriyama , Relationships among personality traits, metabolic syndrome, and metabolic syndrome scores: the Kakegawa cohort study., J. Psychosomatic Res., 107, 20-25 (2018),, 2018.02.
37. Masaomi Nimata, Hideki Okada, Kei Kurihara, Tsukasa Sugimoto, Tsutomu Honjoh, Kazuhiko Kuroda, Takeo Yano, Hirofumi Tachibana, and Masahiro Shoji , A harmonized immunoassay with liquid chromatograph-mass spectrometry analysis in egg allergen determination., Anal. Bioanal. Chem., 410, 325-335 (2018), 10.1007/s00216-017-0721-z., 2018.02.
38. Motofumi Kumazoe, Mai Yamashita, Yuki Nakamura, Kanako Takamatsu, Jaehoon Bae, Shuya Yamashita, Shuhei Yamada, Hiroaki Onda, Takashi Nojiri, Kenji Kangawa, and Hirofumi Tachibana, Green tea polyphenol EGCG upregulates Tollip expression by suppressing Elf-1 expression., J. Immunol., 199, 3261-3269 (2017), 10.4049/jimmunol.1601822., 2017.07.
39. Jaehoon Bae, Motofumi Kumazoe, Shuya Yamashita, Hirofumi Tachibana, Hydrogen sulphide donors selectively potentiate a green tea polyphenol EGCG-induced apoptosis of multiple myeloma cells., Sci. Rep., 7, 6665 (2017), 10.1038/s41598-017-06879-5, 2017.07.
40. Masafumi Wasai, Nobuaki Urata, Yuji Fujii, Akiyoshi Kawaoka, Hirofumi Tachibana, Suguru Fujiwara, Katsuhisa Sakano, Mayumi Hayashi, Shukuko Ebihara, Effect of Sunrouge on the postprandial blood glucose level., Jpn. Pharmacol. Ther., 45, 105-111(2017), 2017.07.
41. Won, YS., Kumazoe, M., Takamatsu, K., Shinoda, Y., Sonoda, S., Okada, K., Okamoto, T., Tachibana, H., Green tea cultivar 'Benifuuki' potentiates split vaccine-induced immunoglobulin A production, J. Nat. Med., 71, 68-75(2017), 10.1007/s11418-016-1028-7, 2017.07.
42. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Mai Kadomatsu, Takashi Nojiri, Hiroaki Onda, Jaehoon, B., Yuhui Huang, Takamatsu, K., Shuya Yamashita, Kenji Kangawa, Hirofumi Tachibana, The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma., J. Biol. Chem., doi:10.1074/jbc.M116.772111, 10.1074/jbc.M116.772111, 2017.05.
43. Yoshinori Fujimura, Chihiro Kawano, Ayaka Maeda-Murayama, Asako Nakamura, Kanako Takamatsu, Akiko Koike-Miki, Daichi Yukihira, Eisuke Hayakawa, Takanori Ishii, Hirofumi Tachibana, Hiroyuki Wariishi, Daisuke Miura, A Chemometrics-driven Strategy for the Bioactivity Evaluation of Complex Multicomponent Systems and the Effective Selection of Bioactivity-predictive Chemical Combinations., Sci. Rep., 7, 2257 (2017), 2017.04.
44. Motofumi Kumazoe, Takai, M., Jaehoon, B., Yuhui Huang, Takamatsu, K., Won, YS., Hiroi,S., Shuya Yamashita, Shuhei Yamada, Murata, M., Tsukamoto, S., Hirofumi Tachibana, FOXO3 is essential for CD44 expression in pancreatic cancer cells.
, Oncogene, doi:10.1038/onc.2016.426, 2017.03.
45. Motofumi Kumazoe, Yuki Nakamura, Mai Yamashita, Takashi Suzuki, Takamatsu, K., Yuhui Huang, Jaehoon, B., Shuya Yamashita, Murata, M., Shuhei Yamada, Yuki Shinoda, Wataru Yamaguchi, Yui Toyoda, Hirofumi Tachibana, Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Upregulation of E3 Ubiquitin-protein Ligase RNF216., J. Biol. Chem., 292, 4077-4088 (2017), 2017.03.
46. Motofumi Kumazoe, Mika Takai, Shun Hiroi, Chieri Takeuchi, Kanako Takamatsu, Yuhui Huang, Jaehoon, B., Shuya Yamashita, Shuhei Yamada, Maasa Yamanouchi, Takashi Nojiri, Hiroaki Onda, Kenji Kangawa, Takashi Takahashi, Hiroshi Tanaka, Hirofumi Tachibana, PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma., Sci. Rep., 7, 1917 (2017), 2017.03.
47. Yuhui Huang, Mami Sumida,, Motofumi Kumazoe, Kaori Sugihara, Yumi Suemasu, Shuhei Yamada, Shuya Yamashita, Jyunichi Miyakawa, Takashi Takahashi, Hiroshi Tanaka, Fujimura Y, Hirofumi Tachibana, Oligomer formation of a tea polyphenol, EGCG on its sensing molecule the 67-kDa laminin receptor., Chemical Communication, 53, 1941-1944 (2017) ., 34, 2017.02.
48. Tsukamoto, S., Kumazoe, M., Huang, Y., Yamada, S., Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana, SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells
, Br. J. Haematol., in press, 2016.08.
49. Yamashita, M., Kumazoe, K., Nakamura, N., Won, YS., Bae, J., Yamashita, S., Hirofumi Tachibana, The Combination of Green Tea Extract and Eriodictyol Inhibited High-Fat/High-Sucrose Diet-Induced Cholesterol Upregulation Accompanied by Suppression of Cholester, J.Nutr.Sci.Vit., 62, 249-256 (2016), 2016.08.
50. Hamagami, H., Kumazoe, K., Yamaguchi,Y., Fuse,S., Hirofumi Tachibana, Tanaka, H., 6-Azido-6-deoxy-L-idose as a hetero-bifunctional spacer for the synthesis of zido-containing chemical probes.
, Chemistry - Eur. J., 22, 12884-12890 (2016)., 2016.08.
51. Shiraishi, N., Kumazoe, K., Fuse,S., Hirofumi Tachibana, Tanaka, H., The synthesis of trans-flavan-3-ol gallates by regioselective oxidative etherification and their cytotoxicity mediated by 67LR., Chemistry - Eur. J.,22, 13050-13053 (2016). , 2016.08.
52. Kim, YH., Won, Y., Xue, Y., Kumazoe, K., Yamashita, S., Hara, A., Takagaki, A., Goto,K., Nanjo,F., Hirofumi Tachibana, Green Tea Catechin Metabolites Derived from Intestinal Bacteria Exert Immunoregulatory Effects on CD4+ T Cell and Natural Killer Cell Activity, J. Agri. Food Chem., 64, 3591-3597 (2016), 34, 1162-1168, 2016.07.
53. Imbe, H., Sano, H., Miyawaki, M., Fujisawa, R., Miyasato, M., Nakatsuji, M., Haseda, F., Tanimoto, K., Hanafusa, T., Terasaki, J., Hirofumi Tachibana, Maeda-Yamamoto, M., "Benifuuki" Green Tea, Containing O-methylated EGCG, Reduces Serum Low-Density Lipoprotein Cholesterol and Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B: A Double-Blind, Placebo-Controlled Randomized Trial, J. Fuct. Foods 25, 25-37 (2016), 2016.07.
54. Motoki Murata, Haruna Nonaka, Satomi Komatsu, Kumazoe, K., Megumi Goto, Mai Morozumi, Shuhei Yamada, I-Chian Lin, Yamashita, S., Hirofumi Tachibana, Delphinidin prevents muscle atrophy and upregulates miR-23a expression., J. Agri. Food Chem., 65, 45-50 (2017)., 34, 1162-1168, 2016.07.
55. Lin, IC., Yamashita, S., Murata, M., Kumazoe, M., Hirofumi Tachibana, Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice.

, J. Nutr. Biochem., 32, 101-106 (2016), 6, 19225, 2016.05.
56. Hatasa, Y, Chikazawa, M., Furuhashi, M., Nakashima, F., Shibata, T., Kondo, T., Akagawa, M., Tanaka, H., Hirofumi Tachibana, Uchida, K., Oxidative Deamination of Serum Albumins by (-)-Epigallocatechin-3-O-gallate: Potential Mechanism for the Formation of Innate Antigens by Antioxidants, PLoS ONE, 11(4), e0153002 (2016), 2016.05.
57. Yamada, S., Tsukamoto1, S., Huang, Y., Makio, A, Kumazoe, K., Yamashita, S., Hirofumi Tachibana, Epigallocatechin-3-O-gallate up-regulates microRNA-let-7b expression by activating 67-kDa laminin receptor signaling in melanoma cells
, Scientific Reports, 6, 19225 , 2016.01.
58. Yamada, S., Baba, K, Makio, A, Kumazoe, K., Huang, Y., Yamashita, S., Lin, IC., Bae, J., Murata, M., Yamada, S., Hirofumi Tachibana, γ-Tocotrienol upregulates aryl hydrocarbon receptor expression and enhances the anticancer effect of baicalein., Biochem. Biophys. Res. Commun., 473, 801-807(2016)., 6, 19225, 2016.01.
59. Tsukamoto, S., Huang, Y., Kumazoe, M., Kim, YH., Yamashita, S., Murata, M., Suzuki, T., Ueda, N., Yoshinori Fujimura, Lesnick, C., Kay, E.N., Shanafelt, D.T., Hirofumi Tachibana, Sphingosine kinase-1 protects B-cell neoplasm and myeloid leukemia from apoptosis driven by cancer specific inhibition of RTKs., Mol. Cancer Theraputic., doi:10.1158/1535-7163.MCT-15-0185, 2015.08.
60. Kumazoe, M., Yoshinori Fujimura, Shiori HIdaka, Kim, YH., Tsukamoto, S., Kanako Murayama, Mika Takai, Huang, Y., Yamashita, S., Daisuke Miura, Mari Maeda-Yamamoto, Hirofumi Tachibana, Metabolic profiling-based data-mining for an effective chemical combination to induce apoptosis of cancer cells., Sci. Rep., 5, 9474, 2015.03.
61. Kim, YH., Yamashita, S., Kumazoe, M., Huang, Y., Shiori HIdaka, Nakahara, K., Won, YS., Murata, M., Lin, I., Koji Yamada, Hirofumi Tachibana, Pentagalloylglucose increases a population of T regulatory cells and inhibits IgE production in ovalbumin-sensitized mouse, Int. Immunopharmacol., 26, 30-36, 2015.03.
62. Tsukamoto, S., Huang, Y., Umeda , D., Yamashita, S., Kumazoe, M., Murata, M., Kim, YH., Koji Yamada, Hirofumi Tachibana, 67kDa-laminin receptor-dependent PP2A activation elicits melanoma-specific antitumor activity overcoming drug resistance., J. Biol. Chem., 10.1074/jbc.M114.604983, 2014.12.
63. Kim, Y.H., Shuya Yamashita, Kumazoe, M., Yuhui Huang, Motoki Murata, Won, YS., Yamada, K., Ninomiya,Y., Tachibana H., IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation, Biochem. Biophys. Res. Commun., 450, 824-830, 2014.09.
64. Kumazoe, M., Tsukamoto, S., Lesnick, C, Kay, N. E., Koji Yamada, Shanafelt T. D., Hirofumi Tachibana, Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells., Br. J. Haematol. , 10.1111/bjh.13135, 2014.09.
65. Kim, YH., Yoshinori Fujimura, Masako Sasaki, Yang, X., Daichi Yukihira, Daisuke Miura, Unno, Y., Ogata, K., Hiroyuki Wariishi, Nakajima, H., Yamashita, S., Koji Yamada, Hirofumi Tachibana, Kanami Nakahara, Murata, M., Lin,I., In situ label-free visualization of orally dosed strictinin within mouse kidney by MALDI-MS imaging., J. Agri. Food Chem., 62, 9279-9285, 2014.09.
66. Takashi Suzuki, Shuya Yamashita, Yukari Tsurudome, Motofumi Kumazoe, Huang, Y., Kanami Nakahara, Yuki Shinoda, Wataru Yamaguchi, Mari Maeda-Yamamoto, Koji Yamada, Hirofumi Tachibana, Green Tea Extract Containing a Highly Absorbent Catechin Prevents Diet-Induced Lipid Metabolism Disorder., Scientific. Reports, 10.1038/srep02749, 3, 2749, 2013.09.
67. Kim, YH., Yoshinori Fujimura, Nagao, T, Takatoki Hagihara, Masako Sasaki, Daichi Yukihira, Daisuke Miura, HIroshi Tanaka, Saito, D., Hiroyuki Wariishi, Koji Yamada, Hirofumi Tachibana, In situ label-free imaging for visualizing biotransformation of bioactive polyphenol., Scientific Reports, 10.1038/srep02805, 3, 2805, 2013.09.
68. Kim, Y.H., Nakayama, K., Yoshimoto, M., Tanino, S., Koji Yamada, Hirofumi Tachibana, 1,2,3,4,6-penta-O-galloyl-β-D-glucose from tannic acid inhibits antigen-specific IgE production by inhibiting  germline transcription induced by STAT6 activation. , FEBS Open Bio, 10.1016/j.fob.2013.07.008, 2013.08.
69. Kumazoe, M., Kim, Y-H., Tsukamoto, S., Huang, Y., Nakahara, K., Bae, JH., Takai, M., Suemasu, Y., Motoki Murata, Sugihara, K., 山下 修矢, Koji Yamada, Hirofumi Tachibana, Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis.
, FEBS Letter, org/10.1016/j.febslet.2013.07.041, 2013.08.
70. Kumazoe, M., Sugihara, K., Tsukamoto, S., Huang, Y., Tsurudome, Y., Suzuki, T., Suemasu, Y., Yamashita, S., Kim, Y-H., Koji Yamada, Hirofumi Tachibana, 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis., J.Clin.Invest., 123, 787-799, 2013.02.
71. Tsukamoto, S., Yamashita, S., Kim, Y.H., Kumazoe, M., Huang, Y., Koji Yamada, Hirofumi Tachibana, Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG., FEBS Lett., 586, 3441-3447, 2012.08.
72. Yamashita, S., Yano, S., Tsukamoto, S., Kumazoe, M., Kim, Y-H., Koji Yamada, Hirofumi Tachibana, Isoflavones suppress the expression of the FcεRI high-affinity IgE receptor independently of estrogen receptor., J. Agric. Food Chem., 60, 8, 8379-8385, 2012.08.
73. Fujimura, Y., Sumida, M. Sugihara, K., Tsukamoto, S., Yamada, K., and Tachibana, H. , Green Tea Polyphenol EGCG Sensing Motif on the 67-kDa Laminin Receptor., PLoS ONE, e37942, 7(5) (2012)., 2012.05.
74. Tsukamoto, S., Hirotsu, K., Kumazoe, M., Goto, Y., Sugihara, K., Suda, T., Tsurudome, Y., Suzuki, T., Yamashita, S., Kim, Y., Huang, Y., Yamada, K., and Tachibana, H. , Green tea polyphenol EGCG induces lipid raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through 67-kDa laminin receptor in multiple myeloma cells., Biochem. J., 443, 525-534, 2012.02.
75. Fujimura, Y., Kurihara, K., Ida, M., Kosaka, R., Miura, D., Wariishi, H., Maeda-Yamamoto, M., Nesumi, A., Saito, T., Kanda, T., Yamada, K., and Tachibana, H., Metabolomics-Driven Nutraceutical Evaluation of Diverse Green Tea Cultivars, PLoS ONE, 585, e23426, 6(8), 2011.05.
76. Byun, E.-H., Omura, T., Yamada, K., and Tachibana, H. , Green tea polyphenol epigallocatechin-3-gallate inhibites TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor., FEBS Lett., 585, 814-820, 2011.03.
77. Lee JH., Kishikawa M., Kumazoe M., Yamada K., and Tachibana H., Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa Laminin Receptor., PLoS ONE, 5, 6, e11051, 2010.06.
78. Byun E-H., Fujimura Y., Yamada K., and Tachibana H., TLR 4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor., J. Immunol., 185, 33-45, 2010.06.
79. Yamashita, S., Yamashita, T., Yamada, K., and Tachibana, H., Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain., FEBS Lett., 587, 775-779, 2010.03.
80. Fujimura, Y., Umeda, D., Yamada, K., and Tachibana, H., The impact of the 67 kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins, Arch. Biochem. Biophys. , 476 (2), 133-138, 2008.07.
81. Umeda, D., Yano, S., Yamada, K., and Tachibana, H., Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells, Biochem. Biophys. Res. Commun., 371, 172-176, 2008.06.
82. Umeda, D., Yano, S., Yamada, K., and Tachibana, H., Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor, J. Biol. Chem., 283, 3050-3058, 2008.02.
83. Fujimura, Y., Umeda, D., Yano, S., Maeda-Yamamoto, M., Yamada, K., and Tachibana, H., The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG, Biochem. Biophys. Res. Commun., 364, 79-85, 2007.10.
84. Yano, S., Umeda, D., Yamashita, T., Ninomiya, Y., Sumida,M., Fujimura, Y., Yamada, K., and Tachibana, H., Dietary flavones suppress IgE and Th2 cytokines in OVA-immunized BALB/c mice, Eur J. Nutr., 46, 5, 257-263, 2007.05.
85. Ikeda, Y., Murakami, M., Fujimura, Y., Tachibana, H., Yamada, K., Hirano, K., Masuda, D., Ohigashi, H., The aggregated ursolic acid, a natural triterpenoid, induces interleukin-1β release in murine peritoneal macrophages: A role of CD36, J. Immunol., 178, 4854-4864, 2007.04.
86. Yano, S., Fujimura, Y., Umeda, D., Miyase, T., Yamada, K, and Tachibana,H. , Relationship between biological activities of methylated derivatives of EGCG and their cell surface binding activities, J. Agric. Food Chem., 55, 17, 7144-7148, 2007.03.
87. Fujimura,Y., Yamada, K., and Tachibana, H., The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate, Biochem. Biophys. Res. Commun., 348, 524-531 , 2006.11.
88. Fujimura,Y., Yamada, K., and Tachibana, H., A lipid raft-associated 67 kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcεRI expression , Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.08.146, 336, 2, 674-681, 348, 524-531 , 2005.08.
89. Nakaya, M., Tachibana, H., and Yamada, K., Isoflavone genestein and daizein up-regulate LPS-inducible oxide synthase activity through estrogen receptor pathway in RAW264.7 cells, Biochem. Pharmacol., 10.1016/j.bcp.2005.10.002, 71, 1-2, 108-114, 71, 108-114 , 2005.06.
90. Umeda, D., Tachibana, H, and Yamada, K., Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67kDa laminin receptor, Biochem. Biophys. Res. Commun., 10.1016/j.bbrc.2005.05.108, 333, 2, 628-635, 336, 674-681 , 2005.06.
91. Yamasaki, M, Miyamoto, Y, Chujo, H, Nishiyama, K, Tachibana,H, Yamada, K, Trans10,cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilizationinrat hepatoma cells , Biochim Biophys Acta, 10.1016/j.bbalip.2005.05.010, 1735, 3, 176-184, 1735, 176-184 , 2005.02.
92. Tachibana, H., Koga, K., Fujimura, Y., and Yamada, K., A receptor for green tea polyphenol EGCG, Nature Struc. Mol. Biol., 10.1038/nsmb743, 11, 4, 380-381, 11, 380-381, 2004.04.
93. Maeda-Yamamoto, M., Inagaki, N., Kitaura, J., Chikumoto, T., Kawahara, H., Kawakami,Y., Sano, M., Miyase, T., Tachibana, H., Nagai, H., and Kawakami, T., O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells, J. Immunol.,, 172, 7, 4486-4492, 172, 4486-4492, 2004.04.
94. Fujimura, Y., Tachibana, H., and Yamada, K., Lipid raft-associated catechin suppresses the FceRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2, FEBS Lett., 10.1016/S0014-5793(03)01432-7, 556, 1-3, 204-210, 556, 204-210, 2004.01.
95. Yamasaki, M., Ikeda, A., Oji, M., Tanaka, Y., Hirao, A., Kasai, M., Iwata, T., Tachibana, H., and Yamada, K., Modulation of body fat and serum leptin levels by dietary conjugated  linoleic acid in Sprague-Dawley rats fed various fat level diets., Nutrition, 10.1016/S0899-9007(02)00842-0, 19, 1, 30-35, 19, 30-35, 2003.01.
96. Yamasaki, M., Chujo, H., Hirao, A., Koyanagi, N., Okamoto, T., Tojo, N., Oishi, A., Iwata, T., Yamauchi-Sato, Y., Yamamoto, T., Tsutsumi , K., Tachibana, H., and Yamada, K., Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid., J. Nutr., 133, 3, 784-788, 133, 784-788, 2003.01.
97. Tachibana, H., Haruta, H., Ueda, K., Chiwata, T. and Yamada, K., Induction of light chain replacement in human plasma cells by caffeine independent from enhancement of RAG proteins expression and germ-line transcription., J. Biol. Chem., 10.1074/jbc.275.8.5927, 275, 8, 5927-5933, 275, 5927-5933, 2000.08.
98. Tachibana, H., Haruta, H. and Yamada, K., Light Chain Shifting: Identification of a human plasma cell line actively undergoing light chain replacement., Blood, 93, 1, 198-207, 93, 198-207, 1999.04.
1. Hiroshi Tanaka, Motofumi Kumazoe, Yosuke Tanimoto, Yumi Suemasu, Yuhui Huang, Koji Yamada, Hirofumi Tachibana, Takashi Takahashi, Synthesis of a fluorescent labeled EGCG as a cancer tracer, 20TH INTERNATIONAL CONGRESS OF NUTRITION. GRANADA 2013, 2013.09.
2. Hirofumi Tachibana, Motoki Murata, Reia Kosaka, Kana Kurihara, Atsushi Nesumi, Mari Maeda-Yamamoto, Koji Yamada, Green Tea Extract Suppresses Disuse Muscle Atrophy in Mice, 20TH INTERNATIONAL CONGRESS OF NUTRITION. GRANADA 2013, 2013.09.
3. 熊添基文, 立花 宏文, 67-kDa laminin receptor and cGMP induced cancer-selective apoptosis, 6th International Conference on cGMP generators, effectors and therapeutic implications , 2013.06.
4. Yoshiyuki Miyazaki, Masaji Nakamizo, Tetsuya Shibasaki, Tomomi Kirino, Yuzu Saito, Kazuhiro Kawahara, Ken Otsuka, 山田 耕路, 立花 宏文, Daisuke Tachikawa, Protective effects of orally administered fucoidan mix on immunosuppression by an experimental cancer chemotherapy., Imuunology 2013 AAI Annual meating, 2013.05.
5. 立花 宏文, Green tea polyphenol EGCG sensing for cancer prevention, The 6th International Niigata symposium on Diet and Health, 2012.10.
Educational Activities
Tutorials on Food Chemistry
Professional and Outreach Activities
Bio-oriented technology research advancement institution
Ohtsuka pharmacy
MAFF Food research project.