Updated on 2024/07/28

Information

 

写真a

 
OHGA SHOICHI
 
Organization
Faculty of Medical Sciences Department of Clinical Medicine Professor
Kyushu University Hospital Pediatrics(Joint Appointment)
School of Medicine Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medicine(Joint Appointment)
Graduate School of Medical Sciences Department of Medical Sciences(Joint Appointment)
Title
Professor
Contact information
メールアドレス
Tel
0926425421
Profile
I have continued medical research in the field of pediatric hematology and immunology, especially focusing on bone marrow failure, lymphoproliferative disease, infectious diseases, immunodeficiency diseases and autoimmune diseases. I have continued medical education for students and postgraduate students, and clinical practice and instructions for young pediatricians and staffs. I have also supported the patient advocacy group of aplastic anemia in Japan. Recently, I have continued to participate in the management of the Kyushu University Hospital Comprehensive Maternity and Perinatal Care Center, and have participated in the environmental improvement project of regional medicine.
External link

Degree

  • MD. PhD

Research History

  • 1984 九州大学医学部附属病院医員研修医 1985 福岡市立こども病院感染症センター(医員研修医) 1986 東国東地域広域国保総合病院 1987 九州大学医学部附属病院医員 1989 糸田町立緑が丘病院小児科医長 1991 九州大学医学部附属病院医員   1991 九州大学医学部附属病院助手(小児科) 1997 九州大学医学部周産母子センター講師(併任) 2000 九州大学医学部付属病院講師 2006 九州大学病院周産母子センター助教授 2010 九州大学大学院医学研究院周産期小児医療学[寄附講座]教授 2014 山口大学大学院医学系研究科小児科学講座 教授 2016 九州大学大学院医学研究院成長発達医学 教授

    1984 九州大学医学部附属病院医員研修医 1985 福岡市立こども病院感染症センター(医員研修医) 1986 東国東地域広域国保総合病院 1987 九州大学医学部附属病院医員 1989 糸田町立緑が丘病院小児科医長 1991 九州大学医学部附属病院医員   1991 九州大学医学部附属病院助手(小児科) 1997 九州大学医学部周産母子センター講師(併任) 2000 九州大学医学部付属病院講師 2006 九州大学病院周産母子センター助教授 2010 九州大学大学院医学研究院周産期小児医療学[寄附講座]教授 2014 山口大学大学院医学系研究科小児科学講座 教授 2016 九州大学大学院医学研究院成長発達医学 教授

  • 山口大学大学院医学系研究科小児科学講座 教授 2014年3月1日~2016年5月31日

Research Interests・Research Keywords

  • Research theme:Pathophysiology and treatment of refractory Epstein-Barr virus associated diseases

    Keyword:Epstein-Barr virus

    Research period: 1991.1

  • Research theme:Pathogenesis and treatment of bone marrow failure

    Keyword:aplastic anemia, inherited bone marrow failure syndrome

    Research period: 1991.1

Awards

  • 平成15年度合屋賞

    2003.6   九州大学医学部小児科同門会   Epstein-Barr virus感染症の免疫応答

Papers

  • Non-conditioned cord blood transplantation for infection control in athymic CHARGE syndrome Reviewed International journal

    Sonoda M, Ishimura M, Inoue H, Eguchi K, Ochiai M, Sakai Y, Doi T, Suzuki K, Inoue T, Mizukami T, Nakamura K, Takada H, Ohga S

    Pediatr Blood Cancer   71 ( 3 )   e30809   2024.5

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  • Outcomes of extracorporeal membrane oxygenation support for pediatric emergency patients in regional and metropolitan areas in Japan Reviewed International journal

    Kaku N, Matsuoka W, Ide K, Totoki T, Hirai K, Mizuguchi S, Higashi K, Tetsuhara K, Nagata H, Nakagawa S, Kakihana Y, Shiose A, Ohga S

    Pediatrics and Neonatol   2024.4

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  • Skeletal muscle mass (SMM) assessment in pediatric patients: development of a normative equation and assessment of factors associated with a low SMM in PICU patients Reviewed International journal

    Matsuoka W, Mizuguchi S, Kaku N, Higashi K, Tetsuhara K, Akahoshi T, Ohga S

    Pediatric Critical Care Medicine   2024.4

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  • Rapid and long-lasting efficacy of high-dose ambroxol therapy for neuronopathic Gaucher disease: A case report and literature review Reviewed International journal

    Higashi K, Sonoda Y, Kaku N, Fujii F, Yamashita F, Lee S, Tocan V, Ebihara G, Matsuoka W, Tetsuhara K, Sonoda M, Chong PF, Mushimoto Y, Kojima-Ishii K, Ishimura M, Koga Y, Fukuta A, Tsuchihashi AN, Kikuchi Y, Karashima T, Sawada T, Hotta T, Yoshimitsu M, Terazono H, Tajiri T, Nakagawa T, Sakai Y, Nakamura K, Ohga S

    Mol Genet Genomic Med   12 ( 4 )   e2427   2024.4

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  • The immunoreactive signature of monocyte-derived dendritic cells from patients with Down syndrome Reviewed International journal

    Nakashima K, Imai T, Shiraishi A, Unose R, Goto H, Nagatomo Y, Kojima-Ishii K, Mushimoto Y, Nishiyama K, Yamamura K, Nagata H, Ishimura M, Kusuhara K, Koga Y, Sakai Y, Ohga S

    Clin Exp Immunol   2024.4

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  • Vitamin K prophylaxis in neonates: Comparing two different oral regimens Reviewed International journal

    Takahashi D, Egami N, Ochiai M, Hotta T, Suga S, Ishimura M, Kawaguchi C, Uchiumi T, Nishikubo T, Nogami K, Goto K, Ohga S

    J Perinatol   2024.4

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  • The Effect of Parental Age on Child Development : Insights from the Japan Environment and Children's Study Reviewed International journal

    Fukuda T, Shimono M, Suga R, Igarashi R, Yoshino K, Fujino Y, Tsuji M, Ishitsuka K, Sanefuji M, Ohga S, Kusuhara K, on behalf of the Japan Environment and Children's Study Group

    Research in Developmental Disabilities   2024.4

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  • Early hematopoietic cell transplantation for familial hemophagocytic lymphohistiocytosis in a regional treatment network in Japa Reviewed International journal

    Ishimura M, Eguchi K, Sonoda M, Tanaka T, Shiraishi A, Sakai Y, Yasumi T, Miyamoto T, Voskoboinik I, Hashimoto K, Matsumoto S, Ozono S, Moritake H, Takada H, Ohga S

    Int J Hematol   2024.3

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  • The clinical and genetic landscape of early-onset thrombophilia in Japan Reviewed International journal

    Egami N, Ishimura M, Ochiai M, Ichiyama M, Inoue H, Suenobu S, Nishikubo T, Nogami K, Ishiguro A, Hotta T, Uchiumi T, Kang D, Ohga S

    Pediatr Blood Cancer   71 ( 3 )   e39824   2024.3

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  • Progressive myoclonic epilepsy as an expanding phenotype of NGLY1-associated congenital deglycosylation disorder: A case report and review of the literature Reviewed International journal

    Sonoda Y, Fujita A, Torio M, Mukaino T, Sakata A, Matsukura M, Yonemoto K, Hatae K, Ichimiya Y, Chong PF, Ochiai M, Wada Y, Kadoya M, Okamoto N, Murakami Y, Suzuki T, Isobe N, Shigeto H, Matsumoto N, Sakai Y, Ohga S

    Eur J Med Genet   67   104895   2024.2

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  • Long-term renal involvement in association with Fontan circulation Reviewed International journal

    Muraoka M, Nagata H, Yamamura K, Sakamoto I, Ishikita A, Nishizaki A, Eguchi Y, Fukuoka S, Uike K, Nagatomo Y, Hirata Y, Nishiyama K, Tsutsui H, Ohga

    Pediatr Cardiol   45 ( 2 )   340 - 350   2024.2

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  • STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells Reviewed International journal

    Yada Y, Matsumoto M, Inoue T, Baba A, Higuchi R, Kawai C, Yanagisawa M, Kitamura D, Ohga S, Kurosaki T, Baba Y

    J Exp Med   221 ( 1 )   e20222178   2024.1

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  • Divergent neurodevelopmental profiles of very-low-birth-weight infants Reviewed International journal

    Ogata R, Watanabe K, Chong PF, Okamoto J, Sakemi Y, Nakashima T, Ohno T, Nomiyama H, Sonoda Y, Ichimiya Y, Inoue H, Ochiai M, Yamashita H, Sakai Y, Ohga S

    Pediatr Res   95 ( 1 )   233 - 240   2024.1

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  • Pediatric leukemia and maternal occupational exposure to anticancer drugs: The Japan Environment and Children’s Study Reviewed International journal

    143 ( 4 )   311 - 319   2024.1

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  • CD14 down-modulation as a real-time biomarker in Kawasaki disease. Reviewed International journal

    Inada Y, Sonoda M, Mizuno Y, Yamamura K, Motomura Y, Takuma A, Murata K, Furuno K, Tezuka J, Sakai Y, Ohga S, Kishimoto J, Hosaka K, Sakata S, Hara T

    13 ( 1 )   e1482   2023.12

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  • Occupational exposure of pregnant women to refined oil and infant wheezing: Japan environment and children's study findings Reviewed International journal

    Kawamura M, Shimono M, Suga R, Yoshino K, Fujino Y, Tsuji M, Sanefuji M, Ohga S, Hoshina T, Kusuhara K

    Clin Exp Allergy   53 ( 12 )   1302 - 1306   2023.12

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  • Clinical features of pediatric uveitis at a tertiary referral center in the western region of Japan Reviewed International journal

    Fukuda Y, Yawata N, Hasegawa E, Yamana S, Shirane M, Ito T, Takeda A, Sonoda M, Eguchi K, Ishimura M, Ohga S, Sonoda KH

    Ocul Immunol Inflamm   31 ( 10 )   2032 - 2038   2023.12

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  • Critical diseases in neonates after discharge home from birth hospital: A retrospective study from a tertiary hospital in Japan Reviewed International journal

    Fujiyoshi J, Inoue H, Sawano T, Mushimoto Y, Motomura Y, Nishiyama K, Kaku N, Nagata H, Yamamura K, Ishimura M, Koga Y, Ochiai M, Sakai Y, Tajiri T, Ohga S

    Early Hum Dev   186   195869   2023.11

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  • Updated Guidelines for Chronic active Epstein-Barr Virus Disease Reviewed International journal

    Kawada JI, Ito Y, Ohshima K, Yamada M, Kataoka S, Muramatsu H, Sawada A, Wada T, Imadome KI, Arai A, Iwatsuki K, Ohga S, Kimura H; Committee for Guidelines for the Management of Chronic Active EBV Disease, Related Disorders (the MHLW Research Team in Japan)

    Int J Hematol   118 ( 5 )   568 - 576   2023.11

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  • Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca2+ regulation in autism spectrum disorder Reviewed International journal

    Dong S, Kifune T, Kato H, Wang L, Kong J, Hirofuji Y, Sun X, Sato H, Ito Y, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K

    Biochem Biophys Res Commun   681   7 - 12   2023.11

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  • TRPV4-mediated Ca2+ deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons Reviewed International journal

    5 ( 12 )   507 - 520   2023.10

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  • Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with DNA mismatch repair deficient (dMMR) tumors, third edition Reviewed International journal

    Mishima S, Naito Y, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, Kato M, Kenmotsu H, Kodera Y, Komine K, Koyama T, Maeda O, Miyachi M, Nishihara H, Nishiyama H, Ohga S, Okamoto W, Oki E, Ono S, Sanada M, Sekine I, Takano T, Tao K, Terashima K, Tsuchihara K, Yatabe Y, Yoshino T, Baba E

    Int J Clin Oncol.   28 ( 10 )   1237 - 1258   2023.10

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  • Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells Reviewed International journal

    Yonemoto K, Fujii F, Taira R, Ohgidani M, Eguchi K, Okuzono S, Ichimiya Y, Sonoda Y, Chong PF, Goto H, Kanemasa H, Motomura Y, Ishimura M, Koga Y, Tsujimura K, Hashiguchi T, Torisu H, Kira R, Kato TA, Sakai Y, Ohga S

    Clin Immunol   255   109756   2023.10

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  • Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children's Study cohort Reviewed International journal

    BMC Pediatr   23 ( 1 )   479   2023.9

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  • Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children's Study Reviewed International journal

    Iwaya Y, Sanefuji M, Nishiyama K, Sonoda Y, Hamada N, Suga R, Ochiai M, Shimono M, Kusuhara K, Ohga S; Japan Environment and Children's Study Group

    Sci Total Environ   890   164356   2023.9

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  • POT1a deficiency in mesenchymal niches perturbs B-lymphopoiesis Reviewed International journal

    Nakashima K, Kunisaki Y, Hosokawa K, Gotoh K, Yao H, Yuta R, Semba Y, Nogami J, Kikushige Y, Stumpf PS, MacArthur BD, Kang D, Akashi K, Ohga S, Arai F

    Commun Biol.   6 ( 1 )   996   2023.9

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  • Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of immunotherapy in patients with high tumor mutational burden tumors Reviewed International journal

    Mishima S, Naito Y, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, Kato M, Kenmotsu H, Kodera Y, Komine K, Koyama T, Maeda O, Miyachi M, Nishihara H, Nishiyama H, Ohga S, Okamoto W, Oki E, Ono S, Sanada M, Sekine I, Takano T, Tao K, Terashima K, Tsuchihara K, Yatabe Y, Yoshino T, Baba E

    Int J Clin Oncol   28 ( 8 )   941 - 955   2023.8

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  • Long-lasting pain and somatosensory disturbances in children with myelin oligodendrocyte glycoprotein antibody-associated disease Reviewed International journal

    Ichimiya Y, Chong PF, Sonoda Y, Tocan V, Watanabe M, Torisu H, Kira R, Takahashi T, Kira J-I, Isobe N, Sakai Y, Ohga S

    Eur J Pediatr   182 ( 7 )   3175 - 3185   2023.7

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    DOI: 10.1007/s00431-023-04989-z

  • Diagnostic and disease severity determination criteria for hydroa vacciniforme lymphoproliferative disorders and severe mosquito bite allergy Reviewed International journal

    Hirai Y, Asada H, Hamada T, Kawada JI, Kimura H, Arai A, Ohshima K, Ohga S, Iwatsuki K; Committee for Guidelines for the Management of Chronic Active EBV Disease and Related Disorders (the MHLW Research Team in Japan)

    J Dermatol   50 ( 7 )   e198 - e205   2023.7

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  • Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors Reviewed International journal

    Naito Y, Mishima S, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, Kato M, Kenmotsu H, Kodera Y, Komine K, Koyama T, Maeda O, Miyachi M, Nishihara H, Nishiyama H, Ohga S, Okamoto W, Oki E, Ono S, Sanada M, Sekine I, Takano T, Tao K, Terashima K, Tsuchihara K, Yatabe Y, Yoshino T, Baba E

    Int J Clin Oncol   28 ( 7 )   827 - 840   2023.7

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  • Sleep quality and temperament in association with autism spectrum disorder among infants in Japan Reviewed International journal

    Commun Med (Lond)   3 ( 1 )   82   2023.6

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  • Changing risk factors for postpartum depression in mothers admitted to a perinatal center Reviewed International journal

    Sakemi Y, Nakashima T, Watanabe K, Ochiai M, Sawano T, Inoue H, Kawakami K, Isomura S, Yamashita H, Ohga S.

    PEDIATRICS AND NEONATOLOGY   64 ( 3 )   319 - 326   2023.5

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    DOI: 10.1016/j.pedneo.2022.09.013

  • Gestational weight gain growth chart adapted to Japanese pregnancies using a Bayesian approach in a longitudinal study Reviewed International journal

    J Epidemiol   33 ( 5 )   217 - 226   2023.5

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  • Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice. Reviewed International journal

    Okuzono S, Fujii F, Matsushita Y, Setoyama D, Shinmyo Y, Taira R, Yonemoto K, Akamine S, Motomura Y, Sanefuji M, Sakurai T, Kawasaki H, Han K, Kato TA, Torisu H, Kang D, Nakabeppu Y, Sakai Y, Ohga S.

    EPIGENOMICS   2023.3

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    DOI: 10.1016/j.neures.2023.03.001

  • Molecular diagnosis of 405 individuals with autism spectrum disorder Reviewed International journal

    Miyake N, Tsurusaki Y, Fukai R, Kushima I, Okamoto N, Ohashi K, Nakamura K, Hashimoto R, Hiraki Y, Son S, Kato M, Sakai Y, Osaka H, Deguchi K, Matsuishi T, Takeshita S, Fattal-Valevski A, Ekhilevitch N, Tohyama J, Yap P, Keng WT, Kobayashi H, Takubo K, Okada T, Saitoh S, Yasuda Y, Murai T, Nakamura K, Ohga S, Matsumoto A, Inoue K, Saikusa T, Hershkovitz T, Kobayashi Y, Morikawa M, Ito A, Hara T, Uno Y, Seiwa C, Ishizuka K, Shirahata E, Fujita A, Koshimizu E, Miyatake S, Takata A, Mizuguchi T, Ozaki N, Matsumoto N

    Eur J Hum Genet   2023.3

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  • Human RELA dominant-negative mutations in underlie a type I interferonopathy with autoinflammation and autoimmunity Reviewed International journal

    Moriya K, Nakano T, Honda Y, Tsumura M, Ogishi M, Sonoda M, Nishitani-Isa M, Uchida T, Hbibi M, Mizoguchi Y, Ishimura M, Izawa K, Asano T, Kakuta F, Abukawa D, Rinchai D, Zhang P, Kambe N, Bousfiha A, Yasumi T, Nishikomori R, Boisson B, Puel A, Casanova J-L, Ohga S, Sasahara Y, Kure S.

    J Exp Med   2023.3

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  • Variant spectrum of PIEZO1 and KCNN4 in Japanese patients with dehydrated hereditary stomatocytosis Reviewed International journal

    Shimojima Yamamoto K, Nakahara E, Ogura H, Aoki T, Utsugisawa T, Azuma K, Akagawa H, Watanabe K, Muraoka M, Nakamura F, Kamei M, Tatebayashi K, Shinozuka J, Yamane T, Hibino M, Katsura Y, Nakano-Akamatsu S, Kadowaki N, Maru Y, Ito E, Ohga S, Yagasaki H, Morioka I, Yamamoto T, Kanno H.

    Human Genome Variation   2023.2

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  • Clinical outcomes of pulmonary agenesis: A systematic review of the literature Reviewed International journal

    Fukuoka S, Yamamura K, Nagata H, Toyomura D, Nagatomo Y, Eguchi Y, Uike K, Hirata Y, Inoue H, Ochiai M, Ohga S.

    PEDIATRIC PULMONOLOGY   57 ( 12 )   3060 - 3068   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ppul.26135

  • Targeting hepatic oxidative stress rescues bone loss in liver fibrosis Reviewed International journal

    MOLECULAR METABOLISM   66   2022.12

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.molmet.2022.101599

  • Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study. Reviewed International journal

    American Journal of Kidney Diseases   80 ( 5 )   619 - 628   2022.11

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    DOI: 10.1053/j.ajkd.2022.03.003.

  • Third-line therapies in patients with Kawasaki disease refractory to first- and second-line intravenous immunoglobulin therapy Reviewed International journal

    Furuta T, Okada S, Ohnishi Y, Kawakami-Miyake A, Suzuki Y, Ohga S, Hasegawa S

    WORLD JOURNAL OF PEDIATRICS   18 ( 11 )   781 - 785   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/s12519-022-00602-9

  • Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes Reviewed International journal

    Chong PF, Torio M, Fujii F, Hirata Y, Matsuoka W, Sonoda Y, Ichimiya Y, Yada Y, Kaku N, Ishimura M, Sasazuki M, Koga Y, Sanefuji M, Sakai Y, Ohga S.

    EUROPEAN JOURNAL OF CLINICAL NUTRITION   76 ( 11 )   1618 - 1621   2022.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41430-022-01170-x

  • Characteristics of intussusception in the era of arbitrary Rotavirus vaccination: A two-center retrospective study Invited Reviewed International journal

    Nakamura M, Yoshimaru K, Matsuura T, Hamada H, Takahashi Y, Irie K, Okuzono S, Shunichi A, Motomura Y, Kawano Y, Uchida Y, Kajihara K, Toriigahara Y, Shirai T, Hayashida M, Ohga S, Tajiri T, Taguchi T.

    Pediatr Int   2022.10

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  • A predictive score for detecting vesicoureteral reflux in children with first Escherichia coli-induced urinary tract infection Reviewed International journal

    Kurokawa M, Murata M, Hoshina T, Furuno K, Kaku Y, Kishimoto J, Ohga S.

    Int J Urol   2022.10

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  • Clinical conditions and risk factors for inhibitor-development in patients with haemophilia: A decade-long prospective cohort study in Japan, J-HIS2 (Japan Hemophilia Inhibitor Study 2) Reviewed International journal

    Nogami K, Taki M, Matsushita T, Kojima T, Oka T, Ohga S, Kawakami K, Sakai M, Suzuki T, Higasa S, Horikoshi Y, Shinozawa K, Tamura S, Yada K, Imaizumi M, Ohtsuka Y, Iwasaki F, Kobayashi M, Takamatsu J, Takedani H, Nakadate H, Matsuo Y, Matsumoto T, Fujii T, Fukutake K, Shirahata A, Yoshioka A, Shima M, J-HIS2 study group

    Haemophilia   2022.9

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  • Association of sleep quality with temperament among one-month-old infants in The Japan Environment and Children's Study Reviewed International journal

    PLOS ONE   17 ( 9 )   2022.9

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1371/journal.pone.0274610

  • No association between prenatal lead and neurodevelopment during early childhood in the Japan Environment and Children’s Study Reviewed International journal

    Inoue H, Sanefuji M, Sonoda Y, Ogawa M, Hamada N, Shimono M, Suga R, Nakayama SF, Taniguchi Y, Kusuhara K, Ohga S, Kamijima M, The Japan Environment and Children’s Study Group

    2022.9

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  • Lung to thorax transverse area ratio as a predictor of neurodevelopmental outcomes in fetuses with congenital diaphragmatic hernia Reviewed International journal

    EARLY HUMAN DEVELOPMENT   170   2022.7

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.earlhumdev.2022.105598

  • Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency Reviewed International journal

    Sun X, Dong S, Kato H, Kong J, Ito Y, Hirofuji Y, Sato H, Kato TA, Sakai Y, Ohga S, Fukumoto S, Masuda K.

    ANTIOXIDANTS   11 ( 7 )   2022.7

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    DOI: 10.3390/antiox11071361

  • The Utility of Core-Needle Tumor Biopsy for Pediatric Patients – A single center experience Reviewed International journal

    2022.6

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  • Optimal teicoplanin dosing regimen in neonates and children developed by leveraging real-world clinical information Invited Reviewed International journal

    Yamada T, Fukuda T, Emoto C, Motomura Y, Inoue H, Ohga S, Ieiri I

    Therapeutic Drug Monitoring   44 ( 3 )   404 - 413   2022.6

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  • Sustained association between early formula and reduced risk of cow’s milk allergy: The Japan Environment and Children’s Study Reviewed International journal

    Ikari K, Tezuka J, Sanefuji M, Nakayama J, Nishima D, Sonoda Y, Ogawa M, Shimono M, Suga R, Honjo S, Kusuhara K, Ohga S, The Japan Environment and Children’s Study (JECS) Group

    2022.6

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  • An efficient procedure for the recovery of DNA from formalin-fixed paraffin-embedded tissue sections Reviewed International journal

    Oba U, Kohashi K, Sangatsuda Y, Oda Y, Sonoda K-H, Ohga S, Yoshimoto K, Arai Y, Yachida S, Shibata T, Ito T, Miura F.

    Biology Methods & Protocols   2022.6

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  • Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants Reviewed International journal

    Commun Med (Lond)   2 ( 35 )   2022.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s43856-022-00101-y

  • Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome Reviewed International journal

    Sun X, Kato H, Sato H, Han X, Zhang Yu, Hirofuji Y, Kato T, Sakai Y, Ohga S, Fukumoto S, Masuda K.

    FASEB BioAdvances   2022.4

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    Language:Japanese   Publishing type:Research paper (scientific journal)  

    DOI: 10.1096/fba.2021-00086

  • Fluctuations of aeroallergen-specific immunoglobulins and children’s allergic profiles: pilot JECS cohort Reviewed International journal

    2022.3

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  • Association of maternal hemoglobin levels during pregnancy with sleep and developmental problems in 1-year-old infants: A cohort study Reviewed International journal

    Nakahara K, Michikawa T, Morokuma S, Hamada N, Ogawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Shimono M, Kawamoto T, Ohga S, Kusuhara K; Japan Environment and Children's Study Group

    Sci Rep   5 ( 2 )   e552   2022.3

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  • Case Report: Rotavirus Vaccination and Severe Combined Immunodeficiency in Japan Invited Reviewed International journal

    Tanita K, Kawamura Y, Miura H, Mitsuiki N, Tomoda T, Inoue K, Iguchi A, Yamada M, Yoshida T, Muramatsu H, Tada N, Matsui T, Kato M, Eguchi K, Shouichi Ohga, Masataka Ishimura, Kohsuke Imai, Tomohiro Morio, Tetsushi Yoshikawa, Hirokazu Kanegane.

    FRONTIERS IN IMMUNOLOGY   13   2022.2

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    DOI: 10.3389/fimmu.2022.786375

  • Effect of age on exercise-induced bronchoconstriction in children and adolescents with asthma Reviewed International journal

    Motomura C, Matsuzaki H, Odajima H, Oki T, Yasunari Y, Kawano T, Iwata M, Okabe K, Wakatsuki M, Murakami Y, Taba N, Honjo S, Ohga S

    J Asthma   59 ( 2 )   297 - 305   2022.2

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  • Lack of catch‑up in weight gain may intermediate between pregnancies with hyperemesis gravidarum and reduced fetal growth: the Japan Environment and Children’s Study Reviewed International journal

    Morisaki N, Nagata C, Morokuma S, Nakahara K, Kato K, Sanefuji M, Shibata E, Tsuji M, Shimono M, Kawamoto T, Ohga S, Kusuhara K,10 and Japan Environment, Children’s Study Group

    2022.2

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  • The earliest enzyme replacement for infantile-onset Pompe disease in Japan Reviewed International journal

    Tocan V, Mushimoto Y, Kojima-Ishii K, Matsuda A, Toda N, Toyomura D, Hirata Y, Sanefuji M, Sawada T, Sakai Y, Nakamura K, Ohga S.

    PEDIATRICS INTERNATIONAL   64 ( 1 )   2022.1

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    DOI: 10.1111/ped.15286

  • Serum erythroferrone levels during the first month of life in premature infants Reviewed International journal

    J Perinatol   42 ( 1 )   97 - 102   2022.1

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  • Characteristics of intussusception in the period of arbitrary Rotavirus vaccination Reviewed International journal

    Nakamura M, Yoshimaru K, Matsuura T, Hamada H, Motomura Y, Hayashida M, Ohga S, Tajiri T, Hara T, Taguchi T.

    PEDIATRICS INTERNATIONAL   64 ( 1 )   2022.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.15332

  • Cholangiogenic potential of human deciduous pulp stem cell-converted hepatocyte-like cells

    Ratih Yuniartha, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Stem Cell Research & Therapy   12 ( 1 )   2021.12

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    DOI: 10.1186/s13287-020-02113-8

  • Granulocyte collection by polymorphonuclear cell-targeting apheresis with medium-molecular-weight hydroxyethyl starch. Reviewed International journal

    Henzan T, Yamauchi T, Yamanaka I, Sakoda T, Semba Y, Hayashi M, Kikushige Y, Mishima H, Ishimura M, Koga Y, Miyamoto T, Ohga S, Akashi K, Maeda T, Kunisaki Y

    Int J Hematol   114 ( 6 )   691 - 700   2021.12

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  • Progressive B cell depletion in human MALT1 deficiency Reviewed International journal

    Clin Exp Immunol   206 ( 3 )   237 - 247   2021.12

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  • Hepatocyte polarity establishment and apical lumen formation are organized by Par3, Cdc42, and aPKC in conjunction with Lgl Invited Reviewed International journal

    Tocan V, Hayase J, Kamakura S, Kohda A, Ohga S, Kohjima M, Sumimoto H

    J Biol Chem   297 ( 6 )   101354   2021.12

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  • Current status of newborn screening for Pompe disease in Japan Invited Reviewed International journal

    Sawada T, Kido J, Sugawara K, Momosaki K, Yoshida S, Kojima-Ishii K, Inoue T, Matsumoto S, Endo F, Ohga S, Hirose S, Nakamura K

    Orphanet J Rare Dis   16 ( 1 )   516   2021.12

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  • Biliary atresia-specific deciduous pulp stem cells feature biliary deficienc Invited Reviewed International journal

    Sonoda S, Yoshimaru K, Yamaza H, Yuniartha R, Matsuura T, Yamauchi-Tomoda E, Murata S, Nishida K, Oda Y, Ohga S, Tajiri T, Taguchi T, Yamaza T

    Stem Cell Res Ther   12 ( 1 )   582   2021.11

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  • Clinical impact of heritable thrombophilia on neonatal-onset thromboembolism: A nationwide study in Japan Reviewed International journal

    Egami N, Ochiai M, Ichiyam M, Inoue H, Sonoda M, Ishimura M, Suenobu S, Nishikubo T, Ishiguro A, Hotta T, Uchiumi T, Kang D, Ohga S

    J Pediatr   238   259 - 267   2021.11

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  • Survival outcomes of very low birth weight infants with trisomy 18 Reviewed International journal

    Inoue H, Matsunaga Y, Sawano T, Fujiyoshi J, Kinjo T, Ochiai M, Nagata K, Matsuura T, Taguchi T, Ohga S.

    Am J Med Genet A   185 ( 11 )   3459 - 3465   2021.11

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  • Clinical and electrophysiological features of acute flaccid myelitis: A national cohort study

    Pin Fee Chong, Hiroyuki Torisu, Sawa Yasumoto, Akihisa Okumura, Harushi Mori, Tatsuharu Sato, Jun Kimura, Shouichi Ohga, Keiko Tanaka-Taya, Ryutaro Kira

    Clinical Neurophysiology   132 ( 10 )   2456 - 2463   2021.10

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    DOI: 10.1016/j.clinph.2021.07.013

  • Neurodevelopmental outcomes of high-risk preterm infants: A prospective study in Japan Reviewed International journal

    Torio M, Iwayama M, Sawano T, Inoue H, Ochiai M, Taira R, Yonemoto K, Ichimiya Y, Sonoda Y, Sasazuki M, Ishizaki Y, Sanefuji M, Yamane K, Yamashita H, Torisu H, Kira R, Hara T, Kanba S, Sakai Y, Ohga S

    Neurol Clin Pract   11 ( 5 )   398 - 405   2021.10

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  • Optimization of lymphapheresis for manufacturing autologous CAR-T cells.

    Ikumi Yamanaka, Takuji Yamauchi, Tomoko Henzan, Teppei Sakoda, Kyoko Miyamoto, Hiroyuki Mishima, Hiroaki Ono, Yuhki Koga, Yasuhiro Nakashima, Koji Kato, Toshihiro Miyamoto, Shinichi Mizuno, Yoshihiro Ogawa, Shouichi Ohga, Koichi Akashi, Takahiro Maeda, Yuya Kunisaki

    International journal of hematology   114 ( 4 )   449 - 458   2021.10

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    DOI: 10.1007/s12185-021-03191-x

  • Alectinib-responsive infantile anaplastic ganglioglioma with a novel VCL-ALK gene fusion. International journal

    Shunsuke Yamamoto, Yuhki Koga, Hiroaki Ono, Hironori Goto, Nobuhiro Hata, Hidetaka Yamamoto, Satoshi O Suzuki, Yasunari Sakai, Toru Iwaki, Shouichi Ohga

    Pediatric blood & cancer   68 ( 9 )   e29122   2021.9

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    DOI: 10.1002/pbc.29122

  • Female-dominant estrogen production in healthy young children before adrenarche Reviewed International journal

    Igarashi M, Ayabe T, Yamamoto-Hanada K, Matsubara K, Sasaki H, Saito-Abe M, Sato M, Mise N, Ikegami A, Shimono M, Suga R, Ohga S, Sanefuji M, Oda M, Mitsubuchi H, Michikawa T, Yamazaki S, Nakayama S, Ohya Y, Fukami M

    Endocr Connect   10 ( 10 )   1221 - 1226   2021.9

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  • Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis Reviewed International journal

    358   577656   2021.9

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  • Measles antibody seropositivity among children with allergic diseases: A cross-sectional study in the Japan Environment & Children's Pilot Study Reviewed International journal

    Saito-Abe M, Yamamoto-Hanada K, Shoji K, Sato M, Irahara M, Taniguchi Y, Sekiyama M, Mise N, Ikegami A, Shimono M, Suga R, Sanefuji M, Ohga S, Oda M, Mitsubuchi H, Miyairi I, Ohya Y

    PLoS One   16 ( 9 )   e0257721   2021.9

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  • Brain-sparing cord blood transplantation for the borderline stage of adrenoleukodystrophy. International journal

    Yutaro Yada, Michiko Torio, Yuhki Koga, Fumiya Yamashita, Takuya Ichimura, Katsuhide Eguchi, Masataka Ishimura, Yuichi Mushimoto, Akio Hiwatashi, Momoko Sasazuki, Ryutaro Kira, Yasunari Sakai, Shouichi Ohga

    Molecular genetics and metabolism reports   28   100778 - 100778   2021.9

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    DOI: 10.1016/j.ymgmr.2021.100778

  • Age-related morphological differences in the spike-and-wave complexes of absence epilepsy. International journal

    Yuri Sonoda, Masafumi Sanefuji, Yuko Ichimiya, Michiko Torio, Eriko Watanabe, Ayumi Sakata, Yoshito Ishizaki, Yasunari Sakai, Shouichi Ohga

    Epilepsy research   174   106647 - 106647   2021.8

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    DOI: 10.1016/j.eplepsyres.2021.106647

  • Detailed analysis of Japanese patients with adenosine deaminase 2 deficiency reveals characteristic elevation of type II interferon signature and STAT1 hyperactivation Reviewed International journal

    Nihira H, Izawa K, Ito M, Umebayashi H, Okano T, Kajikawa S, Nanishi E, Keino D, Murakami K, Isa-Nishitani M, Shiba T, Honda Y, Hijikata A, Yasu T, Kubota T, Hasegawa Y, Kawashima Y, Nakano N, Takada H, Ohga S, Heike T, Takita J, Ohara O, Takei S, Takahashi M, Kanegane H, Morio T, Iwaki-Egawa S, Sasahara Y, Nishikomori R, Yasumi T

    J Allergy Clin Immunol   148 ( 2 )   550 - 562   2021.8

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  • Mitochondrial reactive oxygen species are essential for the development of psoriatic inflammation. Reviewed International journal

    Mizuguchi S, Gotoh K, Nakashima Y, Setoyama D, Takata Y, Ohga S, Kang D

    Front Immunol   6 ( 12 )   714897   2021.8

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  • Physical growth and neurodevelopment during the first year of life: a cohort study of the Japan Environment and Children's Study. International journal

    Masafumi Sanefuji, Yuri Sonoda, Yoshiya Ito, Masanobu Ogawa, Vlad Tocan, Hirosuke Inoue, Masayuki Ochiai, Masayuki Shimono, Reiko Suga, Ayako Senju, Satoshi Honjo, Koichi Kusuhara, Shouichi Ohga

    BMC pediatrics   21 ( 1 )   360 - 360   2021.8

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    DOI: 10.1186/s12887-021-02815-9

  • Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children's Study. International journal

    Masafumi Sanefuji, Ayako Senju, Masayuki Shimono, Masanobu Ogawa, Yuri Sonoda, Michiko Torio, Yuko Ichimiya, Reiko Suga, Yasunari Sakai, Satoshi Honjo, Koichi Kusuhara, Shouichi Ohga

    BMJ open   11 ( 8 )   e043202   2021.8

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    DOI: 10.1136/bmjopen-2020-043202

  • Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia

    Xiao Sun, Hiroki Kato, Hiroshi Sato, Michiko Torio, Xu Han, Yu Zhang, Yuta Hirofuji, Takahiro A. Kato, Yasunari Sakai, Shouichi Ohga, Satoshi Fukumoto, Keiji Masuda

    Biochemistry and Biophysics Reports   26   100968 - 100968   2021.7

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    DOI: 10.1016/j.bbrep.2021.100968

  • Overlapping arthritis between Kawasaki disease and systemic-onset juvenile idiopathic arthritis: a nationwide study in Japan Reviewed International journal

    Kanemasa H, Nanishi E, Takada H, Ishimura M, Nishio H, Honjo S, Masuda H, Nagai N, Nishihara T, Ishii T, Adachi T, Hara S, Lin L, Tomita Y, Kamizono J, Komiyama O, Kohdera U, Tanabe S, Sato A, Hida S, Yashiro M, Makino N, Nakamura Y, Hara T, Ohga S

    Front Pediatr   9   597458   2021.7

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  • The immunoregulatory function of peripheral blood CD71 + erythroid cells in systemic-onset juvenile idiopathic arthritis Reviewed International journal

    Kanemasa H, Ishimura M, Eguchi K, Tanaka T, Nanishi E, Shiraishi A, Goto M, Motomura Y, Ohga S

    Sci Rep   11 ( 1 )   14396   2021.7

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  • Study protocol for a multicentre, open-label, single-arm phase I/II trial to evaluate the safety and efficacy of ripasudil 0.4% eye drops for retinopathy of prematurity Reviewed International journal

    Arima M, Inoue H, Nakao S, Misumi A, Suzuki M, Matsushita I, Araki S, Yamashiro C, Takahashi K, Ochiai M, Yoshida N, Hirose M, Kishimoto J, Todaka K, Hasegawa S, Kimura K, Kusuhara K, Kondo H, Ohga S, Sonoda KH

    BMJ Open   11 ( 7 )   e047003   2021.7

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  • Kawasaki disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan Reviewed International journal

    Murata K, Onoyama S, Yamamura K, Mizuno Y, Furuno K, Matsubara K, Hatae K, Masuda K, Nomura Y, Ohno T, Kinumaki A, Miura M, Sakai Y, Ohga S, Fukushima W, Kishimoto J, Nakamura Y, Hara T

    Vaccines (Basel)   9 ( 8 )   839   2021.7

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  • Usefulness of a Radiofrequency Transseptal Needle in the Second Puncture of Fontan Extracardiac Conduit. International journal

    Yusaku Nagatomo, Hazumu Nagata, Shoji Fukuoka, Yuichiro Hirata, Kenichiro Yamamura, Shouichi Ohga

    World journal for pediatric & congenital heart surgery   21501351211002769 - 21501351211002769   2021.7

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    DOI: 10.1177/21501351211002769

  • Infantile neuroblastoma and maternal occupational exposure to medical agents. International journal

    Yuhki Koga, Masafumi Sanefuji, Syunichiro Toya, Utako Oba, Kentaro Nakashima, Hiroaki Ono, Shunsuke Yamamoto, Maya Suzuki, Yuri Sonoda, Masanobu Ogawa, Hiroyuki Yamamoto, Koichi Kusuhara, Shouichi Ohga

    Pediatric research   2021.7

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    DOI: 10.1038/s41390-021-01634-z

  • Hemorrhagic stroke due to leukostasis in pediatric mixed-phenotype acute leukemia. International journal

    Shunsuke Yamamoto, Yuhki Koga, Kenichi Tetsuhara, Noriyuki Kaku, Hiroaki Ono, Satoshi O Suzuki, Toru Iwaki, Shouichi Ohga

    Blood research   2021.6

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    DOI: 10.5045/br.2021.2021004

  • Association of maternal sleep before and during pregnancy with sleep and developmental problems in 1-year-old infants Reviewed International journal

    Sci Rep   11 ( 1 )   11834   2021.6

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  • Enhanced airway hyperresponsiveness in asthmatic children and mice with A(H1N1)pdm09 infection Reviewed International journal

    Ariyoshi T, Tezuka J, Yasudo H, Sakata Y, Nakamura T, Matsushige T, Hasegawa H, Nakajima N, Ainai A, Oga A, Itoh H, Shirabe K, Toda S, Atsuta R, Ohga S, Hasegawa S

    Immun Inflamm Dis   9 ( 2 )   457 - 465   2021.6

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  • Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study. International journal

    Kenichi Tetsuhara, Noriyuki Kaku, Yuka Watanabe, Masaya Kumamoto, Yuko Ichimiya, Soichi Mizuguchi, Kanako Higashi, Wakato Matsuoka, Yoshitomo Motomura, Masafumi Sanefuji, Akio Hiwatashi, Yasunari Sakai, Shouichi Ohga

    Scientific reports   11 ( 1 )   12090 - 12090   2021.6

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    DOI: 10.1038/s41598-021-91628-y

  • 低リン血症性くる病の長期管理中に悪性転化したFGF23産生腫瘍の1例

    大山 紀子, 石井 加奈子, 虫本 雄一, 戸田 尚子, 松尾 光通, 大久保 一宏, 古賀 友紀, 井原 健二, 大賀 正一, 薛 宇孝, 小田 義直

    日本小児科学会雑誌   125 ( 5 )   824 - 824   2021.5

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  • Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia Reviewed International journal

    Koyamaishi S, Kamio T, Kobayashi A, Sato T, Kudo K, Sasaki S, Kanezaki R, Hasegawa D, Muramatsu H, Takahashi Y, Sasahara Y, Hiramatsu H, Kakuda H, Tanaka M, Ishimura M, Nishi M, Ishiguro A, Yabe H, Sarashina T, Yamamoto M, Yuza Y, Hyakuna N, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Miyano S, Ogawa S, Toki T, Terui K, Ito E

    Bone Marrow Transplant   56 ( 5 )   1013 - 1020   2021.5

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  • Assessment of Pediatric Admissions for Kawasaki Disease or Infectious Disease During the COVID-19 State of Emergency in Japan. International journal

    Takuya Hara, Kenji Furuno, Kenichiro Yamamura, Junji Kishimoto, Yumi Mizuno, Kenji Murata, Sagano Onoyama, Ken Hatae, Megumi Takemoto, Yoshito Ishizaki, Shunsuke Kanno, Kazuo Sato, Yoshitomo Motomura, Yasunari Sakai, Shouichi Ohga, Mayumi Yashiro, Yoshikazu Nakamura, Toshiro Hara

    JAMA network open   4 ( 4 )   e214475   2021.4

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    DOI: 10.1001/jamanetworkopen.2021.4475

  • Influence of physical activity before and during pregnancy on infant's sleep and neurodevelopment at 1-year-old Reviewed International journal

    Sci Rep   11 ( 1 )   8099   2021.4

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  • Comparison of Simultaneous Quantitative Analysis of Methylmercury and Inorganic Mercury in Cord Blood Using LC-ICP-MS and LC-CVAFS: The Pilot Study of the Japan Environment and Children's Study Reviewed International journal

    Iwai-Shimada M, Kobayashi Y, Isobe T, Nakayama SF, Sekiyama M, Taniguchi Y, Yamazaki S, Michikawa T, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Suga R, Shimono M

    Toxics   9 ( 4 )   82   2021.4

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  • Vitamin A deficiency-associated corneal perforation in a boy with autism spectrum disorder: A case report and literature review. International journal

    Shunichi Adachi, Michiko Torio, Sayaka Okuzono, Yoshitomo Motomura, Yuko Ichimiya, Yuri Sonoda, Jyunya Nagata, Misato Okamoto, Shouji Noutomi, Masafumi Sanefuji, Yasunari Sakai, Shouichi Ohga

    Nutrition (Burbank, Los Angeles County, Calif.)   90   111275 - 111275   2021.4

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    DOI: 10.1016/j.nut.2021.111275

  • De novo ATP1A3 variants cause polymicrogyria. International journal

    Satoko Miyatake, Mitsuhiro Kato, Takuma Kumamoto, Tomonori Hirose, Eriko Koshimizu, Takaaki Matsui, Hideyuki Takeuchi, Hiroshi Doi, Keisuke Hamada, Mitsuko Nakashima, Kazunori Sasaki, Akio Yamashita, Atsushi Takata, Kohei Hamanaka, Mai Satoh, Takabumi Miyama, Yuri Sonoda, Momoko Sasazuki, Hiroyuki Torisu, Toshiro Hara, Yasunari Sakai, Yushi Noguchi, Mazumi Miura, Yoko Nishimura, Kazuyuki Nakamura, Hideyuki Asai, Nodoka Hinokuma, Fuyuki Miya, Tatsuhiko Tsunoda, Masami Togawa, Yukihiro Ikeda, Nobusuke Kimura, Kaoru Amemiya, Asako Horino, Masataka Fukuoka, Hiroko Ikeda, Goni Merhav, Nina Ekhilevitch, Masaki Miura, Takeshi Mizuguchi, Noriko Miyake, Atsushi Suzuki, Shouichi Ohga, Hirotomo Saitsu, Hidehisa Takahashi, Fumiaki Tanaka, Kazuhiro Ogata, Chiaki Ohtaka-Maruyama, Naomichi Matsumoto

    Science advances   7 ( 13 )   2021.3

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    DOI: 10.1126/sciadv.abd2368

  • Trends in Bronchopulmonary Dysplasia Among Extremely Preterm Infants in Japan, 2003-2016. International journal

    Toshinori Nakashima, Hirosuke Inoue, Yoshihiro Sakemi, Masayuki Ochiai, Hironori Yamashita, Shouichi Ohga

    The Journal of pediatrics   230   119 - 125   2021.3

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    DOI: 10.1016/j.jpeds.2020.11.041

  • A novel mutation in early-onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes. International journal

    Fumiko Okazaki, Hiroyuki Wakiguchi, Yuno Korenaga, Tamaki Nakamura, Hiroki Yasudo, Shohei Uchi, Ryoji Yanai, Nobuyuki Asano, Yoshinobu Hoshii, Tsuyoshi Tanabe, Kazushi Izawa, Yoshitaka Honda, Ryuta Nishikomori, Keisuke Uchida, Yoshinobu Eishi, Shouichi Ohga, Shunji Hasegawa

    Pediatric rheumatology online journal   19 ( 1 )   18 - 18   2021.2

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1186/s12969-021-00505-5

  • Portosystemic venous shunt in the patients with Fontan circulation.

    Hazumu Nagata, Ichiro Sakamoto, Shouji Fukuoka, Ayako Ishikita, Kiyoshi Uike, Yusaku Nagatomo, Yuichiro Hirata, Kenichiro Yamamura, Shouichi Ohga

    Heart and vessels   2021.2

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    DOI: 10.1007/s00380-020-01685-y

  • RelAの優性阻害変異により,自己炎症や自己免疫疾患をきたす(Dominant negative RelA mutation causes autoinflammatory and autoimmune disorders)

    森谷 邦彦, 中野 智太, 本田 吉孝, 園田 素史, 津村 弥来, 内田 崇, 石村 匡崇, 井澤 和司, 角田 文彦, 虻川 大樹, 八角 高裕, 岡田 賢, 大賀 正一, 笹原 洋二, 呉 繁夫

    日本小児科学会雑誌   125 ( 2 )   301 - 301   2021.2

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  • Possible association between early formula and reduced risk of cow’s milk allergy: the Japan Environment and Children’s Study Reviewed International journal

    Tezuka J, Sanefuji M, Ninomiya T, Kawahara T, Matsuzaki H, Sonoda Y, Ogawa M, Shimono M, Suga R, Honjo S, Kusuhara K, Ohga S; Japan Environment, Children’s Study (JECS) Group

    51 ( 1 )   99 - 107   2021.1

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  • Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease Invited Reviewed International journal

    Nakashima Y, Sakai Y, Mizuno Y, Furuno K, Hirono K, Takatsuki S, Suzuki H, Onouchi Y, Kobayashi T, Tanabe K, Hamase K, Miyamoto T, Aoyagi R, Arita M, Yamamura K, Tanaka T, Nishio H, Takada H, Ohga S, Hara T

    Cardiovasc Res   117 ( 1 )   96 - 108   2021.1

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  • Postnatal Cytomegalovirus Infection-Associated Hemolytic Anemia in an Infant Born to a Lupus Mother

    Shunsuke Yamamoto, Masataka Ishimura, Keisuke Taku, Yutaro Yada, Katsuhide Eguchi, Wakato Matsuoka, Akira Shiraishi, Hirosuke Inoue, Masayuki Ochiai, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   67   2020.12

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  • GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons Reviewed International journal

    Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S

    FASEB J   34 ( 12 )   16601 - 16621   2020.12

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  • Acute isolated Aspergillus appendicitis in pediatric leukemia

    Yutaro Yada, Yuhki Koga, Hiroaki Ono, Yoshitomo Motomura, Genshiro Esumi, Kenichi Kohashi, Yasunori Muraosa, Katsuhiko Kamei, Toshiharu Matsuura, Yoshinao Oda, Shouichi Ohga

    JOURNAL OF INFECTION AND CHEMOTHERAPY   26 ( 11 )   1229 - 1231   2020.11

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    DOI: 10.1016/j.jiac.2020.07.016

  • Involvement of activated cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis Reviewed International journal

    9 ( 11 )   e1212   2020.11

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  • Prediction of hemodynamics after atrial septal defect closure using a framework of circulatory equilibrium in dogs. International journal

    Kiyoshi Uike, Keita Saku, Takuya Nishikawa, Kenichiro Yamamura, Hazumu Nagata, Mamoru Muraoka, Shouichi Ohga, Hiroyuki Tsutsui, Kenji Sunagawa

    American journal of physiology. Heart and circulatory physiology   319 ( 5 )   H938-H947   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1152/ajpheart.00098.2020

  • Novel COL4A1 mutations identified in infants with congenital hemolytic anemia in association with brain malformations. International journal

    Hiromi Ogura, Shouichi Ohga, Takako Aoki, Taiju Utsugisawa, Hidehiro Takahashi, Asayuki Iwai, Kenichiro Watanabe, Yusuke Okuno, Kenichi Yoshida, Seishi Ogawa, Satoru Miyano, Seiji Kojima, Toshiyuki Yamamoto, Keiko Yamamoto-Shimojima, Hitoshi Kanno

    Human genome variation   7 ( 1 )   42 - 42   2020.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/s41439-020-00130-w

  • Forskolin rapidly enhances neuron‐like morphological change of directly induced‐neuronal cells from neurofibromatosis type 1 patients

    Noriaki Sagata, Shin‐ichi Kano, Masahiro Ohgidani, Shogo Inamine, Yasunari Sakai, Hiroki Kato, Keiji Masuda, Takeshi Nakahara, Makiko Nakahara‐Kido, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba, Takahiro A. Kato

    2020.10

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    Language:Others   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/npr2.12144

  • Hyperferritinemia and acute kidney injury in pediatric patients receiving allogeneic hematopoietic cell transplantation. International journal

    Mari Kurokawa, Kei Nishiyama, Yuhki Koga, Katsuhide Eguchi, Takashi Imai, Utako Oba, Akira Shiraishi, Hazumu Nagata, Noriyuki Kaku, Masataka Ishimura, Satoshi Honjo, Shouichi Ohga

    Pediatric nephrology (Berlin, Germany)   35 ( 10 )   1977 - 1984   2020.10

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    DOI: 10.1007/s00467-020-04619-y

  • Previous antibiotic use and the development of Kawasaki disease: a matched pair case‐control study

    62 ( 9 )   1044 - 1048   2020.9

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    DOI: 10.1111/ped.14255

  • Delayed Development of Coronary Artery Aneurysm in Patients with Kawasaki Disease Who Were Clinically Responsive to Immunoglobulin. International journal

    Ryohei Matsuoka, Kenji Furuno, Etsuro Nanishi, Sagano Onoyama, Hazumu Nagata, Kenichiro Yamamura, Yuichiro Sugitani, Ayako Kuraoka, Yumi Mizuno, Koichi Sagawa, Satoshi Honjo, Toshiro Hara, Shouichi Ohga

    The Journal of pediatrics   2020.8

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    DOI: 10.1016/j.jpeds.2020.08.032

  • The efficacy and safety of infliximab therapy for refractory Kawasaki disease in infants Reviewed International journal

    Furuta T, Yasudo H, Ohnishi Y, Miyake A, Okada S, Suzuki Y, Ohga S, Hasegawa SFuruta T, Yasudo H, Ohnishi Y, Miyake A, Okada S, Suzuki Y, Ohga S, Hasegawa S

    Pediatr Infect Dis J   39 ( 8 )   e219   2020.8

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  • 変容性骨異形成症患者由来の歯髄幹細胞から分化したドーパミン作動性ニューロンではカルシウム蓄積によりミトコンドリア障害と神経突起発達不全をきたす(Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia)

    孫 梟, 加藤 大樹, 佐藤 浩, 鳥尾 倫子, 韓 旭, 張 虞, 廣藤 雄太, 加藤 隆弘, 酒井 康成, 大賀 正一, 福本 敏, 増田 啓次

    日本神経精神薬理学会年会・日本生物学的精神医学会年会・日本精神薬学会総会・学術集会合同年会プログラム・抄録集   50回・42回・4回   201 - 201   2020.8

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  • Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis. International journal

    Kei Nishiyama, Yuka Watanabe, Masataka Ishimura, Kenichi Tetsuhara, Takashi Imai, Hikaru Kanemasa, Kenji Ueki, Yoshitomo Motomura, Noriyuki Kaku, Yasunari Sakai, Ken-Ichi Imadome, Shouichi Ohga

    Open forum infectious diseases   7 ( 8 )   ofaa288   2020.8

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    DOI: 10.1093/ofid/ofaa288

  • Management of apnea in infants with trisomy 18. Reviewed International journal

    Ryoji Taira, Hirosuke Inoue, Toru Sawano, Junko Fujiyoshi, Yuko Ichimiya, Michiko Torio, Masafumi Sanefuji, Masayuki Ochiai, Yasunari Sakai, Shouichi Ohga

    Developmental medicine and child neurology   62 ( 7 )   874 - 878   2020.7

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    DOI: 10.1111/dmcn.14403

  • Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification. International journal

    Ichiro Yonese, Chizuko Sakashita, Ken-Ichi Imadome, Tohru Kobayashi, Masahide Yamamoto, Akihisa Sawada, Yoshinori Ito, Noriko Fukuhara, Asao Hirose, Yusuke Takeda, Masanori Makita, Tomoyuki Endo, Shun-Ichi Kimura, Masataka Ishimura, Osamu Miura, Shouichi Ohga, Hiroshi Kimura, Shigeyoshi Fujiwara, Ayako Arai

    Blood advances   4 ( 13 )   2918 - 2926   2020.7

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    DOI: 10.1182/bloodadvances.2020001451

  • Long‐term outcomes of children with extracutaneous juvenile xanthogranulomas in Japan

    67 ( 7 )   2020.7

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    DOI: 10.1002/pbc.28381

  • Lipopolysaccharide-induced monocyte death in a novel ZnF7 domain mutation of TNFAIP3 Reviewed

    Takashi Imai, Akira Shiraishi, Kei Nishiyama, Masataka Ishimura, Shouichi Ohga

    Journal of Allergy and Clinical Immunology: In Practice   8 ( 6 )   2071 - 2074.e5.   2020.6

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    DOI: 10.1016/j.jaip.2020.01.026

  • 出生時より咽頭喉頭機能不全を呈しGLE1変異が同定された乳児例

    山本 俊亮, 平良 遼志, 碇 航太, 井上 普介, 落合 正行, 賀来 典之, 米元 耕輔, 一宮 優子, 園田 有里, 鳥尾 倫子, 實藤 雅文, 酒井 康成, 吉浦 孝一郎, 大賀 正一

    脳と発達   52 ( 3 )   201 - 201   2020.5

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  • Poly- and perfluoroalkyl substances in maternal serum: Method development and application in the Japan Environment and Children’s Study Pilot Study Reviewed International journal

    1618   460933   2020.5

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  • Associations of Dog and Cat Ownership with Wheezing and Asthma in Children: Pilot Study of the Japan Environment and Children's Stud Reviewed International journal

    Taniguchi Y, Yamazaki S, Michikawa T, Nakayama SF, Sekiyama M, Nitta H, Mezawa H, Saito-Abe M, Oda M, Mitsubuchi H, Sanefuji M, Ohga S, Mise N, Ikegami A, Shimono M, Suga R

    PLoS One   15 ( 5 )   e0232604   2020.5

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  • 生下時より体幹・頸部の筋力低下を示したMYH7変異男児例

    鳥尾 倫子, 一宮 優子, 實藤 雅文, 酒井 康成, 大賀 正一, 大久保 真理子, 井上 道雄, 西野 一三

    脳と発達   52 ( 3 )   200 - 200   2020.5

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  • Gastrointestinal symptoms as an extended clinical feature of Pierson syndrome: a case report and review of the literature. International journal

    Kei Nishiyama, Mari Kurokawa, Michiko Torio, Yasunari Sakai, Mitsuru Arima, Shoko Tsukamoto, Satoshi Obata, Shogo Minamikawa, Kandai Nozu, Noriyuki Kaku, Yoshihiko Maehara, Koh-Hei Sonoda, Tomoaki Taguchi, Shouichi Ohga

    BMC medical genetics   21 ( 1 )   80 - 80   2020.4

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    DOI: 10.1186/s12881-020-01019-9

  • Utility of soluble CD163 in the clinical management of patients with Kawasaki disease Reviewed International journal

    Azuma Y, Suzuki Y, Okada S, Matsuguma C, Wakiguchi H, Ohnishi Y, Furuta T, Miyake A, Yasudo H, Ichihara K, Ohga S, Hasegawa S

    Front Pediatr   8   148   2020.4

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  • The expanding phenotype of hypokalemic periodic paralysis in a Japanese family with p.Val876Glu mutation in CACNA1S. International journal

    Mari Kurokawa, Michiko Torio, Kazuhiro Ohkubo, Vlad Tocan, Noriko Ohyama, Naoko Toda, Kanako Ishii, Kei Nishiyama, Yuichi Mushimoto, Ryuichi Sakamoto, Maki Nakaza, Riho Horie, Tomoya Kubota, Masanori P Takahashi, Yasunari Sakai, Masatoshi Nomura, Shouichi Ohga

    Molecular genetics & genomic medicine   8 ( 4 )   e1175   2020.4

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    DOI: 10.1002/mgg3.1175

  • A model study for the manufacture and validation of clinical-grade deciduous dental pulp stem cells for chronic liver fibrosis treatment Reviewed

    Tsuyoshi Iwanaka, Takayoshi Yamaza, Soichiro Sonoda, Koichiro Yoshimaru, Toshiharu Matsuura, Haruyoshi Yamaza, Shouichi Ohga, Yoshinao Oda, Tomoaki Taguchi

    Stem Cell Research and Therapy   11 ( 1 )   2020.3

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    DOI: 10.1186/s13287-020-01630-w

  • Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study Reviewed International journal

    Yamamoto-Hanada K, Kawakami E, Saito-Abe M, Sato M, Mitsubuchi H, Oda M, Katoh T, Sanefuji M, Ohga S, Kuwajima M, Mise N, Ikegami A, Kayama F, Senju A, Shimono M, Kusuhara K, Yamazaki S, Nakayama SF, Matsumoto K, Saito H, Ohya Y

    Cytokine   130   155051   2020.3

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  • Neurodevelopmental outcomes following intravitreal bevacizumab injection in Japanese preterm infants with type 1 retinopathy of prematurity Reviewed

    Mitsuru Arima, Masato Akiyama, Kohta Fujiwara, Yujiro Mori, Hirosuke Inoue, Eiko Seki, Takahito Nakama, Shoko Tsukamoto, Masayuki Ochiai, Shouichi Ohga, Koh-Hei Sonoda

    PLOS ONE   15 ( 3 )   e0230678 - e0230678   2020.3

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    DOI: 10.1371/journal.pone.0230678

  • Reduction in the number of varicella-zoster virus-specifit-cells in immunocompromised children with varicella Reviewed

    Kenji Murata, Takayuki Hoshina, Sagano Onoyama, Tamami Tanaka, Shunsuke Kanno, Masataka Ishimura, Yuhki Koga, Hideki Nakayama, Shouichi Ohga

    Tohoku Journal of Experimental Medicine   250 ( 3 )   181 - 190   2020.3

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    DOI: 10.1620/tjem.250.181

  • Surge of serum interleukin-2 level in a Japanese patient with cytarabine syndrome Reviewed

    Yasunori Iida, Hiroki Yasudo, Reiji Fukano, Yoshihiro Azuma, Takuya Ichimura, Shouichi Ohga, Shunji Hasegawa

    Pediatric Blood and Cancer   67 ( 3 )   2020.3

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    DOI: 10.1002/pbc.28131

  • Elevated quinolinic acid levels in cerebrospinal fluid in subacute sclerosing panencephalitis Reviewed

    Journal of Neuroimmunology   339   2020.2

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    DOI: 10.1016/j.jneuroim.2019.577088

  • 代理意思決定における小児科医の葛藤と役割

    笹月 桃子, 酒井 康成, 吉良 龍太郎, 戸田 尚子, 一宮 優子, 赤峰 哲, 鳥尾 倫子, 石崎 義人, 實藤 雅文, 奈良間 美保, 板井 孝壱郎, 原 寿郎, 高田 英俊, 木澤 義之, 大賀 正一

    日本小児科学会雑誌   124 ( 2 )   478 - 478   2020.2

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  • Transcutaneous blood gas monitoring among neonatal intensive care units in Japan Reviewed

    Masayuki Ochiai, Hiroaki Kurata, Hirosuke Inoue, Masako Ichiyama, Junko Fujiyoshi, Shinichi Watabe, Takehiko Hiroma, Tomohiko Nakamura, Shouichi Ohga

    Pediatrics International   62 ( 2 )   169 - 174   2020.2

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    DOI: 10.1111/ped.14107

  • Time-Course Evaluation of Body Mass Index in Japanese Children With Obstructive Sleep Apnea Syndrome After Adenotonsillectomy A Three-Years Follow-Up Study Reviewed

    Ken Fukuda, Hiroki Yasudo, Naoki Ohta, Hiroko Narumi, Nozomi Abe, Shunsuke Tarumoto, Hiroshi Yamashita, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa

    Frontiers in Pediatrics   8   2020.2

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    DOI: 10.3389/fped.2020.00022

  • Malignant transformation of phosphaturic mesenchymal tumor A case report and literature review Reviewed

    Noriko Oyama, Kanako Kojima-Ishii, Naoko Toda, Terumichi Matsuo, Vlad Tocan, Kazuhiro Ohkubo, Utako Oba, Yuhki Koga, Nokitaka Setsu, Yuichi Yamada, Kenichi Kohashi, Yasuharu Nakashima, Yoshinao Oda, Kenji Ihara, Shouichi Ohga

    Clinical Pediatric Endocrinology   29 ( 2 )   69 - 75   2020.1

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    DOI: 10.1297/cpe.29.69

  • Survival and ocular preservation in a long-term cohort of Japanese patients with retinoblastoma. International journal

    Tamaki Ueda, Yuhki Koga, Hiroshi Yoshikawa, Mika Tanabe, Kanako Yamana, Utako Oba, Kentaro Nakashima, Hiroaki Ono, Takuya Ichimura, Shunji Hasegawa, Wakako Kato, Tetsuko Kobayashi, Hideki Nakayama, Yasunari Sakai, Tadamasa Yoshitake, Saiji Ohga, Yoshinao Oda, Shigenobu Suzuki, Koh-Hei Sonoda, Shouichi Ohga

    BMC pediatrics   20 ( 1 )   37 - 37   2020.1

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    DOI: 10.1186/s12887-020-1923-7

  • Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis. Reviewed

    Sonoda M, Ishimura M, Eguchi K, Shiraishi A, Kanno S, Kaku N, Inoue H, Motomura Y, Ochiai M, Sakai Y, Nakayama M, Ohara O, Ohga S

    International journal of hematology   111 ( 1 )   131 - 136   2020.1

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    Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis.
    Hemophagocytic lymphohistiocytosis (HLH) occurs in neonates with disseminated infection of herpes simplex virus (HSV). Little has been reported on the control of rapid HLH progression. We studied the cytokine profile and genetic basis of two index cases with divergent outcomes after early treatment of type 2 HSV infection. One survivor had fever and elevated serum levels of tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), interferon (IFN)-beta, and IFN-gamma at diagnosis. The other neonate had no fever or TNF-alpha production, but significant IL-6 or IFN responses during the treatment course, and died 19 days after birth. Among 16 reported cases of neonatal HSV-HLH including index cases, eight deceased neonates experienced significantly less fever at presentation (p = 0.028), lower platelet counts (p = 0.019), and lower ratios of soluble IL-2 receptor (sIL-2R) to ferritin levels (p = 0.044) than eight survivors. The 100-day overall survival rates were significantly higher in patients with fever (p = 0.004), > 100 x 10(9)/L of platelet counts (p = 0.035) or > 20 of sIL-2R/ferritin ratio at diagnosis (p = 0.004). The first febrile and cytokine responses to HSV infection predict the early outcome of neonatal HSV-HLH.

    DOI: 10.1007/s12185-019-02738-3

  • Prognostic factors for survival of herpes simplex virus-associated hemophagocytic lymphohistiocytosis Reviewed

    Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shunsuke Kanno, Noriyuki Kaku, Hirosuke Inoue, Yoshitomo Motomura, Masayuki Ochiai, Yasunari Sakai, Manabu Nakayama, Osamu Ohara, Shouichi Ohga

    International journal of hematology   111 ( 1 )   131 - 136   2020.1

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    DOI: 10.1007/s12185-019-02738-3

  • Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis Reviewed

    Kazuko Kudo, Miho Maeda, Nobuhiro Suzuki, Hirokazu Kanegane, Shouichi Ohga, Eiichi Ishii, Yoko Shioda, Toshihiko Imamura, Shinsaku Imashuku, Yukiko Tsunematsu, Mikiya Endo, Akira Shimada, Yuuki Koga, Yoshiko Hashii, Maiko Noguchi, Masami Inoue, Ken Tabuchi, Akira Morimoto

    International journal of hematology   111 ( 1 )   137 - 148   2020.1

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    DOI: 10.1007/s12185-019-02760-5

  • De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage: A case report and review of the literature. Reviewed

    Kinoshita K, Ishizaki Y, Yamamoto H, Sonoda M, Yonemoto K, Kira R, Sanefuji M, Ueda A, Matsui H, Ando Y, Sakai Y, Ohga S

    European journal of medical genetics   103825   2019.12

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    De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage: A case report and review of the literature.

    DOI: 10.1016/j.ejmg.2019.103825

  • Clinical Features, Molecular Genetics, and Long-Term Outcome in Congenital Chloride Diarrhea A Nationwide Study in Japan Reviewed

    Ken ichiro Konishi, Tatsuki Mizuochi, Tadahiro Yanagi, Yoriko Watanabe, Kazuhiro Ohkubo, Shouichi Ohga, Hidehiko Maruyama, Ichiro Takeuchi, Yuji Sekine, Kei Masuda, Nobuyuki Kikuchi, Yuka Yotsumoto, Yasufumi Ohtsuka, Hidenori Tanaka, Takahiro Kudo, Atsuko Noguchi, Kazumasa Fuwa, Sotaro Mushiake, Shinobu Ida, Jun Fujishiro, Yushiro Yamashita, Tomoaki Taguchi, Ken Yamamoto

    Journal of Pediatrics   214   151 - 157.e6   2019.11

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    DOI: 10.1016/j.jpeds.2019.07.039

  • Clinical features, molecular genetics, and long-term outcome in congenital chloride diarrhea: a nationwide study in Japan Reviewed International journal

    Konishi KI, Mizuochi T, Yanagi T, Watanabe Y, Ohkubo K, Ohga S, Maruyama H, Takeuchi I, Sekine Y, Masuda K, Kikuchi N, Yotsumoto Y, Ohtsuka Y, Tanaka H, Kudo T, Noguchi A, Fuwa K, Mushiake S, Ida S, Fujishiro J, Yamashita Y, Taguchi T, Yamamoto K

    J Pediatr   214   151 - 157   2019.11

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  • S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches. Reviewed

    Kunimura K, Sakata D, Tun X, Uruno T, Ushijima M, Katakai T, Shiraishi A, Aihara R, Kamikaseda Y, Matsubara K, Kanegane H, Sawa S, Eberl G, Ohga S, Yoshikai Y, Fukui Y

    Cell reports   29 ( 9 )   2823 - 2834.e7   2019.11

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    S100A4 Protein Is Essential for the Development of Mature Microfold Cells in Peyer's Patches.

    DOI: 10.1016/j.celrep.2019.10.091

  • Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease. Reviewed International journal

    Yasutaka Nakashima, Yasunari Sakai, Yumi Mizuno, Kenji Furuno, Keiichi Hirono, Shinichi Takatsuki, Hiroyuki Suzuki, Yoshihiro Onouchi, Tohru Kobayashi, Kazuhiro Tanabe, Kenji Hamase, Tomofumi Miyamoto, Ryohei Aoyagi, Makoto Arita, Kenichiro Yamamura, Tamami Tanaka, Hisanori Nishio, Hidetoshi Takada, Shouichi Ohga, Toshiro Hara

    Cardiovascular research   2019.11

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    DOI: 10.1093/cvr/cvz305

  • Association of perinatal factors of epilepsy in very low birth weight infants, using a nationwide database in Japan. Reviewed International journal

    Yuki Matsushita, Yasunari Sakai, Michiko Torio, Hirosuke Inoue, Masayuki Ochiai, Kazuaki Yasuoka, Hiroaki Kurata, Junko Fujiyoshi, Masako Ichiyama, Tomoaki Taguchi, Kiyoko Kato, Shouichi Ohga

    Journal of perinatology : official journal of the California Perinatal Association   39 ( 11 )   1472 - 1479   2019.11

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    DOI: 10.1038/s41372-019-0494-7

  • Psychometric profile of the Ages and Stages Questionnaires, Japanese translation Reviewed

    Hidetoshi Mezawa, Sayaka Aoki, Shoji F. Nakayama, Hiroshi Nitta, Natsuha Ikeda, Keiko Kato, Satoshi Tamai, Makoto Takekoh, Masafumi Sanefuji, Shouichi Ohga, Masako Oda, Hiroshi Mitsubuchi, Ayako Senju, Koichi Kusuhara, Mari Kuwajima, Tatsuya Koeda, Yukihiro Ohya, Keiji Hashimoto

    Pediatrics International   61 ( 11 )   1086 - 1095   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/ped.13990

  • Multi-season analyses of causative pathogens in children hospitalized with asthma exacerbation Reviewed

    Nozomi Abe, Hiroki Yasudo, Reiji Fukano, Tamaki Nakamura, Seigo Okada, Hiroyuki Wakiguchi, Fumiko Okazaki, Komei Shirabe, Shoichi Toda, Reiko Okamoto, Kazunobu Ouchi, Shouichi Ohga, Shunji Hasegawa

    Pediatric Allergy and Immunology   30 ( 7 )   724 - 731   2019.11

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/pai.13102

  • Dynamics of immunocyte activation during intravenous immunoglobulin treatment in Kawasaki disease Reviewed

    Matsuguma C, Wakiguchi H, Suzuki Y, Okada S, Furuta T, Ohnishi Y, Azuma Y, Ohga S, Hasegawa S

    Scandinavian Journal of Rheumatology   48 ( 6 )   491 - 496   2019.11

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    DOI: 10.1080/03009742.2019.1604992

  • Clinical Utility of Highly Purified 10% Liquid Intravenous Immunoglobulin in Kawasaki Disease Reviewed

    Takuya Oda, Hazumu Nagata, Yasutaka Nakashima, Etsuro Nanishi, Yui Takada, Manao Nishimura, Eiji Kubo, Ken Hatae, Shouichi Ohga

    Journal of Pediatrics   214   227 - 230   2019.11

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    DOI: 10.1016/j.jpeds.2019.06.018

  • Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease Reviewed

    Yuji Ohnishi, Hiroki Yasudo, Yasuo Suzuki, Takashi Furuta, Chie Matsuguma, Yoshihiro Azuma, Akiko Miyake, Seigo Okada, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa

    International Journal of Cardiology   292   236 - 240   2019.10

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    DOI: 10.1016/j.ijcard.2019.05.045

  • A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis Reviewed

    Hiroki Hamano, Takeshi Matsushige, Hirofumi Inoue, Madoka Hoshide, Hikaru Kobayashi, Fumitaka Kohno, Momoko Oka, Takashi Ichiyama, Shouichi Ohga, Kazunobu Ouchi, Shunji Hasegawa

    Journal of Clinical Neuroscience   67   270 - 271   2019.9

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    DOI: 10.1016/j.jocn.2019.05.061

  • Successful stent implantation for acute take-off left coronary artery stenosis Reviewed

    Sayo Mori, Hazumu Nagata, Ichiro Sakamoto, Keiji Oi, Shouichi Ohga

    Pediatrics International   61 ( 9 )   933 - 935   2019.9

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    DOI: 10.1111/ped.13942

  • Late-Onset Circulatory Collapse and Risk of Cerebral Palsy in Extremely Preterm Infants Reviewed

    Kazuaki Yasuoka, Hirosuke Inoue, N. Egami, Masayuki Ochiai, Koichi Tanaka, Toru Sawano, Hiroaki Kurata, Masako Ichiyama, J. Fujiyoshi, Yuki Matsushita, Yasunari Sakai, Shouichi Ohga

    Journal of Pediatrics   212   117 - 123.e4   2019.9

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    DOI: 10.1016/j.jpeds.2019.05.033

  • Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis Reviewed

    Tadamune Kinjo, Hirosuke Inoue, Takeshi Kusuda, J. Fujiyoshi, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Y. Koga, Toshiro Hara, Shouichi Ohga

    Pediatrics and Neonatology   60 ( 4 )   382 - 388   2019.8

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    DOI: 10.1016/j.pedneo.2018.09.005

  • Decision-making dilemmas of paediatricians: a qualitative study in Japan. Reviewed International journal

    Momoko Sasazuki, Yasunari Sakai, Ryutaro Kira, Naoko Toda, Yuko Ichimiya, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Masafumi Sanefuji, Miho Narama, Koichiro Itai, Toshiro Hara, Hidetoshi Takada, Yoshiyuki Kizawa, Shouichi Ohga

    BMJ open   9 ( 8 )   e026579   2019.8

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    DOI: 10.1136/bmjopen-2018-026579

  • Critical association of Pallister-Hall syndrome and congenital heart disease. Reviewed International journal

    Masayuki Ochiai, Hazumu Nagata, Koichi Tanaka, Kenji Ihara, Shouichi Ohga

    Pediatrics international : official journal of the Japan Pediatric Society   61 ( 8 )   827 - 828   2019.8

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    DOI: 10.1111/ped.13945

  • Tracheal Size and Morphology on the Reconstructed CT Imaging Reviewed

    Soichi Mizuguchi, Yoshitomo Motomura, Jun Maki, Rieko Baba, Yuko Ichimiya, Kentaro Tokuda, Noriyuki Kaku, Hidetoshi Takada, Yoshihiko Maehara, Shouichi Ohga

    Pediatric Critical Care Medicine   20 ( 8 )   E366 - E371   2019.8

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    DOI: 10.1097/PCC.0000000000001996

  • Serum soluble ST2 as a marker of renal scar in pediatric upper urinary tract infection Reviewed

    Naoki Ohta, Hiroki Yasudo, Makoto Mizutani, Takeshi Matsushige, Reiji Fukano, Setsuaki Kittaka, Kenji Maehara, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa

    Cytokine   120   258 - 263   2019.8

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    DOI: 10.1016/j.cyto.2019.05.006

  • Decision-making dilemmas of paediatricians A qualitative study in Japan Reviewed

    Momoko Sasazuki, Yasunari Sakai, Ryutaro Kira, Naoko Toda, Yuko Ichimiya, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Masafumi Sanefuji, Miho Narama, Koichiro Itai, Toshiro Hara, Hidetoshi Takada, Yoshiyuki Kizawa, Shouichi Ohga

    BMJ open   9 ( 8 )   2019.8

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    DOI: 10.1136/bmjopen-2018-026579

  • Egg antigen was more abundant than mite antigen in children's bedding Findings of the pilot study of the Japan Environment and Children's Study (JECS) Reviewed

    Hiroshi Kitazawa, Kiwako Yamamoto-Hanada, Mayako Saito-Abe, Tadayuki Ayabe, Hidetoshi Mezawa, Kazue Ishitsuka, Mizuho Konishi, Shoji F. Nakayama, Takehiro Michikawa, Ayako Senju, Mayumi Tsuji, Koichi Kusuhara, Masafumi Sanefuji, Shouichi Ohga, Masako Oda, Hiroshi Mitsubuchi, Takahiko Katoh, Akihiko Ikegami, Natan Mise, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya

    Allergology International   68 ( 3 )   391 - 393   2019.7

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    DOI: 10.1016/j.alit.2019.02.005

  • MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner. Reviewed

    Kato W, Nishio M, To Y, Togashi H, Mak TW, Takada H, Ohga S, Maehama T, Suzuki A

    Genes to cells : devoted to molecular & cellular mechanisms   24 ( 7 )   485 - 495   2019.7

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    MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner.

    DOI: 10.1111/gtc.12704

  • Parotid gland carcinoma 32 years' experience from a single institute Reviewed

    T. Nakano, R. Yasumatsu, R. Kogo, K. Hashimoto, K. Asai, S. Ohga, H. Yamamoto, T. Nakashima, T. Nakagawa

    Journal of Laryngology and Otology   133 ( 7 )   604 - 609   2019.7

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    DOI: 10.1017/S0022215119001130

  • MOB1 regulates thymocyte egress and T-cell survival in mice in a YAP1-independent manner Reviewed

    Wakako Kato, Miki Nishio, Yoko To, Hideru Togashi, Tak Wah Mak, Hidetoshi Takada, Shouichi Ohga, Tomohiko Maehama, Akira Suzuki

    Genes to Cells   24 ( 7 )   485 - 495   2019.7

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    DOI: 10.1111/gtc.12704

  • Elevated non-invasive liver fibrosis markers and risk of liver carcinoma in adult patients after repair of tetralogy of Fallot Reviewed

    Kenichiro Yamamura, Ichiro Sakamoto, Eiji Morihana, Yuichiro Hirata, Hazumu Nagata, Yuzo Yamasaki, Yukihiko Okumura, Kenichi Kohashi, Kazuhiro Koto, Hiroyuki Tsutsui, Shouichi Ohga

    International Journal of Cardiology   287   121 - 126   2019.7

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    DOI: 10.1016/j.ijcard.2019.04.032

  • A Nationwide Survey of Pediatric-onset Japanese Encephalitis in Japan Reviewed

    Etsuro Nanishi, Takayuki Hoshina, Masafumi Sanefuji, Ryo Kadoya, Katsuhiko Kitazawa, Yukie Arahata, Tetsuya Sato, Yoshimichi Hirayama, Katsuki Hirai, Masaaki Yanai, Kaori Nikaido, Akihiko Maeda, Hiroyuki Torisu, Kenji Okada, Yasunari Sakai, Shouichi Ohga

    Clinical Infectious Diseases   68 ( 12 )   2099 - 2104   2019.6

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    DOI: 10.1093/cid/ciy816

  • Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder Reviewed

    Huong Thi Nguyen Nguyen, Hiroki Kato, Hiroshi Sato, Haruyoshi Yamaza, Yasunari Sakai, Shouichi Ohga, Kazuaki Nonaka, Keiji Masuda

    Biochemical and Biophysical Research Communications   513 ( 4 )   1048 - 1054   2019.6

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    Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder

    DOI: 10.1016/j.bbrc.2019.04.084

  • Recurrent de novo MAPK8IP3 variants cause neurological phenotypes Reviewed

    Shinya Iwasawa, Kumiko Yanagi, Atsuo Kikuchi, Yasuko Kobayashi, Kazuhiro Haginoya, Hiroshi Matsumoto, Kenji Kurosawa, Masayuki Ochiai, Yasunari Sakai, Atsushi Fujita, Noriko Miyake, Tetsuya Niihori, Matsuyuki Shirota, Ryo Funayama, Shigeaki Nonoyama, Shouichi Ohga, Hiroshi Kawame, Keiko Nakayama, Yoko Aoki, Naomichi Matsumoto, Tadashi Kaname, Yoichi Matsubara, Wataru Shoji, Shigeo Kure

    Annals of Neurology   85 ( 6 )   927 - 933   2019.6

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    DOI: 10.1002/ana.25481

  • Hemostatic assessment of combined anticoagulant therapy using warfarin and prothrombin complex concentrates in a case of severe protein C deficiency Reviewed

    Kenichi Ogiwara, Keiji Nogami, Kuniyoshi Mizumachi, Takashi Nakagawa, Nozomi Noda, Shouichi Ohga, Midori Shima

    International journal of hematology   109 ( 6 )   650 - 656   2019.6

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    DOI: 10.1007/s12185-019-02645-7

  • A child with prostaglandin I2-associated thyrotoxicosis Case report Reviewed

    Yuri Sonoda, Kenichiro Yamamura, Kanako Ishii, Kazuhiro Ohkubo, Kenji Ihara, Yasunari Sakai, Shouichi Ohga

    JCRPE Journal of Clinical Research in Pediatric Endocrinology   11 ( 2 )   207 - 210   2019.6

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    DOI: 10.4274/jcrpe.galenos.2018.2018.0169

  • A nationwide survey of pediatric-onset Japanese encephalitis in Japan Reviewed International journal

    Nanishi E, Hoshina T, Sanefuji M, Kadoya R, Kitazawa K, Arahata Y, Sato T, Hirayama Y, Hirai K, Yanai M, Nikaido K, Maeda A, Torisu H, Okada K, Sakai Y, Ohga S

    Clin Infect Dis   68 ( 12 )   2099 - 2104   2019.5

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    DOI: 10.1093/cid/ciy816.

  • Late-onset sepsis and encephalopathy after bicycle-spoke injury A case report Reviewed

    Ryuichi Takemoto, Yoshitomo Motomura, Noriyuki Kaku, Yuko Ichimiya, Mamoru Muraoka, Shunsuke Kanno, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara, Shouichi Ohga

    BMC Infectious Diseases   19 ( 1 )   2019.5

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    DOI: 10.1186/s12879-019-4082-4

  • Factors predicting the recurrence of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol Reviewed

    109 ( 5 )   612 - 617   2019.5

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    Epstein–Barr virus (EBV)-associated hemophagocytic lymphohistiocytosis (HLH) is highly prevalent in Japan. To date, no standard treatment for EBV–HLH has been established owing to the diversity in treatment response and the difficulty in assessing prognostic factors. The present prospective study recruited 27 children with EBV–HLH who were also part of the HLH-2004 study. EBV load in the peripheral blood was monitored at diagnosis and 2, 4, and 8 weeks after treatment initiation. Additionally, T-cell receptor (TCR) clonality and other laboratory data were evaluated. TCR clonality was positive in 14 patients at diagnosis. Seven of 27 patients experienced recurrences after treatment. No correlation was noted among any clinical data at diagnosis of patients with and without recurrence. However, the recurrence rate was significantly higher in patients aged < 2 years and/or those with a high plasma EBV load of > 103 copies/mL 2 weeks after treatment than that in patients without these factors. These findings suggest that a younger age or a high EBV load in plasma at the early phase of treatment is a factor predicting a recurrence and helps guide the intensity of subsequent treatment phases for children with EBV–HLH.

    DOI: 10.1007/s12185-019-02612-2

  • Correction to Factors predicting the recurrence of Epstein–Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol (International Journal of Hematology, (2019), 109, 5, (612-617), 10.1007/s12185-019-02612-2) Reviewed

    109 ( 5 )   2019.5

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    The correct name of the first author should be ‘‘Ryu Yanagisawa’’, and not ‘‘Ryu Yanagaisawa’’ as given in the original publication of the article.

    DOI: 10.1007/s12185-019-02641-x

  • Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients Reviewed

    Ryota Souzaki, Naonori Kawakubo, Toshiharu Matsuura, Koichiro Yoshimaru, Yuhki Koga, Junkichi Takemoto, Yuichi Shibui, Kenichi Kohashi, Makoto Hayashida, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    Pediatric surgery international   35 ( 5 )   551 - 557   2019.5

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    DOI: 10.1007/s00383-019-04458-5

  • KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells

    Kohara Hiroshi, Utsugisawa Taiju, Sakamoto Chika, Hirose Lisa, Ogawa Yoshie, Ogura Hiromi, Sugawara Ai, Liao Jiyuan, Aoki Takako, Iwasaki Takuya, Asai Takayoshi, Doisaki Sayoko, Okuno Yusuke, Muramatsu Hideki, Abe Takaaki, Kurita Ryo, Miyamoto Shohei, Sakuma Tetsushi, Shiba Masayuki, Yamamoto Takashi, Ohga Shouichi, Yoshida Kenichi, Ogawa Seishi, Ito Etsuro, Kojima Seiji, Kanno Hitoshi, Tani Kenzaburo

    EXPERIMENTAL HEMATOLOGY   73   25-37   2019.5

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    KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells

    DOI: 10.1016/j.exphem.2019.03.001

  • A survey on the status of countermeasures against anticancer drug exposure for families-focus on pediatric cancer hospitals Reviewed

    Momoe Ohta, Yuko Noda, Mami Miyazono, Yuhki Koga, Miho Kifune, Masami Hamada, Tomoaki Taguchi, Shouichi Ohga

    Japanese Journal of Cancer and Chemotherapy   46 ( 4 )   673 - 677   2019.4

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  • The influence of sarcopenia on high-risk neuroblastoma Reviewed International journal

    Kawakubo N, Kinoshita Y, Souzaki R, Koga Y, Oba U, Ohga S, Taguchi T

    J Surg Res   236   101 - 105   2019.4

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  • The Influence of Sarcopenia on High-Risk Neuroblastoma Reviewed

    Naonori Kawakubo, Yoshiaki Kinoshita, Ryota Souzaki, Yuhki Koga, Utako Oba, Shouichi Ohga, Tomoaki Taguchi

    Journal of Surgical Research   236   101 - 105   2019.4

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    DOI: 10.1016/j.jss.2018.10.048

  • Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED) a promising new treatment in pediatric surgery Reviewed

    Tomoaki Taguchi, Yusuke Yanagi, Koichiro Yoshimaru, Xiu Ying Zhang, Toshiharu Matsuura, Koichi Nakayama, Eiji Kobayashi, Haruyoshi Yamaza, Kazuaki Nonaka, Shouichi Ohga, Takayoshi Yamaza

    Surgery today   49 ( 4 )   316 - 322   2019.4

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    DOI: 10.1007/s00595-019-01783-z

  • An acute encephalopathy with reduced diffusion in BRAF-associated cardio-facio-cutaneous syndrome Reviewed

    Sayaka Okuzono, Ryoko Fukai, Marie Noda, Noriko Miyake, Sooyoung Lee, Noriyuki Kaku, Masafumi Sanefuji, Satoshi Akamine, Shunsuke Kanno, Yoshito Ishizaki, Hiroyuki Torisu, Ryutaro Kira, Naomichi Matsumoto, Yasunari Sakai, Shouichi Ohga

    Brain and Development   41 ( 4 )   378 - 381   2019.4

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    DOI: 10.1016/j.braindev.2018.10.012

  • Early canakinumab therapy for the sensorineural deafness in a family with Muckle-Wells syndrome due to a novel mutation of NLRP3 gene Reviewed

    Yasunori Iida, Hiroyuki Wakiguchi, Fumiko Okazaki, Tamaki Nakamura, Hiroki Yasudo, Makoto Kubo, Kazuma Sugahara, Hiroshi Yamashita, Yutaka Suehiro, Naoko Okayama, Kunio Hashimoto, Naoki Iwamoto, Atsushi Kawakami, Yoshiharu Aoki, Hidetoshi Takada, Shoichi Ohga, Shunji Hasegawa

    Clinical Rheumatology   38 ( 3 )   943 - 948   2019.3

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    DOI: 10.1007/s10067-018-4331-8

  • Posttransplant recipient-derived CD4 + T-cell lymphoproliferative disease in X-linked hyper-IgM syndrome Reviewed

    Yasuaki Hagio, Akira Shiraishi, masataka ishimura, Motoshi Sonoda, Katsuhide Eguchi, Hidetaka Yamamoto, Yoshinao Oda, Shoichi Ohga

    Pediatric Blood and Cancer   66 ( 3 )   2019.3

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    DOI: 10.1002/pbc.27529

  • Diagnostic challenge of the newborn patients with heritable protein C deficiency Reviewed

    Masako Ichiyama, Hirosuke Inoue, Masayuki Ochiai, masataka ishimura, Akira Shiraishi, Junko Fujiyoshi, Hironori Yamashita, Kazuo Sato, Shinya Matsumoto, Taeko Hotta, Takeshi Uchiumi, Dongchon Kang, Shoichi Ohga

    Journal of Perinatology   39 ( 2 )   212 - 219   2019.2

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    DOI: 10.1038/s41372-018-0262-0

  • Diagnostic challenge of the newborn patients with heritable protein C deficiency. Reviewed International journal

    Masako Ichiyama, Hirosuke Inoue, Masayuki Ochiai, Masataka Ishimura, Akira Shiraishi, Junko Fujiyoshi, Hironori Yamashita, Kazuo Sato, Shinya Matsumoto, Taeko Hotta, Takeshi Uchiumi, Dongchon Kang, Shouichi Ohga

    Journal of perinatology : official journal of the California Perinatal Association   39 ( 2 )   212 - 219   2019.2

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    DOI: 10.1038/s41372-018-0262-0

  • Therapeutic potential of hepatocyte-like-cells converted from stem cells from human exfoliated deciduous teeth in fulminant Wilson’s disease Reviewed

    9 ( 1 )   1535   2019.2

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    Wilson’s disease (WD) is an inherited metabolic disease arising from ATPase copper transporting beta gene (ATP7B) mutation. Orthotoropic liver transplantation is the only radical treatment of fulminant WD, although appropriate donors are lacking at the onset of emergency. Given the hepatogenic capacity and tissue-integration/reconstruction ability in the liver of stem cells from human exfoliated deciduous teeth (SHED), SHED have been proposed as a source for curing liver diseases. We hypothesized the therapeutic potential of SHED and SHED-converted hepatocyte-like- cells (SHED-Heps) for fulminant WD. SHED and SHED-Heps were transplanted into WD model Atp7b-mutated Long-Evans Cinnamon (LEC) rats received copper overloading to induce a lethal fulminant liver failure. Due to the superior copper tolerance via ATP7B, SHED-Hep transplantation gave more prolonged life-span of fulminant LEC rats than SHED transplantation. The integrated ATP7B-expressing SHED-Heps showed more therapeutic effects on to restoring the hepatic dysfunction and tissue damages in the recipient liver than the integrated naïve SHED without ATP7B expression. Moreover, SHED-Heps could reduce copper-induced oxidative stress via ATP7B- independent stanniocalcin 1 secretion in the fulminant LEC rats, suggesting a possible role for paracrine effect of the integrated SHED-Heps. Taken together, SHED-Heps offer a potential of functional restoring, bridging, and preventive approaches for treating fulminant WD.

    DOI: 10.1038/s41598-018-38275-y

  • Risk prediction of severe reaction to oral challenge test of cow’s milk Reviewed

    178 ( 2 )   181 - 188   2019.2

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    Cow’s milk is one of the most common food allergens among children. Oral food challenge tests determine the threshold dose of allergens, but have not been standardized. To reduce the severe reactions, we developed a practical model of the test. We studied 111 high-risk patients who underwent a first milk oral food challenge on the risk-stratified dose between 2011 and 2017 for predicting the severe reaction risk. Severe reactions were defined as showing > 3 of Sampson’s classification grade. Twenty-eight patients (25%) showed severe reactions without death. Prior to oral food challenge, severe reaction patients experienced milk avoidance (71% vs. 45%, p = 0.02) or bronchial asthma (61% vs. 28%, p = 0.003) more frequently and showed higher milk-specific IgE levels (median 28.3 vs. 7.7 U A /mL, p < 0.0001) than non-severe reaction patients. Multivariate logistic regression analyses established a formula including severe reaction-associated factors; increased levels of milk-specific IgE (odds ratio 11.61, p = 0.001), milk avoidance (odds ratio 3.88, p = 0.02), and bronchial asthma (odds ratio 3.75, p = 0.02). This model had 86% sensitivity and 56% specificity (cut-off 0.25) for risk. Five patients with < 25% probability developed severe reactions, which started in > 3 grade dyspnea up to 20 mL of challenge. Conclusion: This model could effectively reduce the severe reaction development on the first milk oral food challenge test according to the individual needs.What is Known:•Higher levels of milk-specific IgE values, bronchial asthma, and complete milk avoidance are independent risk factors of severe reactions during the cow’s milk oral food challenge.What is New:•Statistical analyses of our milk oral food challenge records for 111 patients helped us develop a model formula predicting severe reactions at the first test with high specificity and sensitivity.•This simple risk-stratified protocol is useful for minimizing the adverse events in the first milk challenge.

    DOI: 10.1007/s00431-018-3274-z

  • Procalcitonin levels predicting the infliximab response of immunoglobulin resistant Kawasaki disease Reviewed

    Yasutaka Nakashima, Etsuro Nanishi, Kenichiro Yamamura, Kiyoshi Uike, Eiko Terashi, Yuichiro Hirata, Hazumu Nagata, Eiji Morihana, Tamami Tanaka, Satoshi Honjo, Hidetoshi Takada, Shoichi Ohga

    Cytokine   114   26 - 31   2019.2

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    DOI: 10.1016/j.cyto.2018.11.025

  • Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 protocol in Japan Reviewed

    Ryu Yanagisawa, Yozo Nakazawa, Kazuyuki Matsuda, Takahiro Yasumi, Hirokazu Kanegane, Shouichi Ohga, Akira Morimoto, Shoichi Ohga, Masue Imaizumi, Yasuhiro Okamoto, Akiko M. Saito, Keizo Horibe, Eiichi Ishii

    International journal of hematology   109 ( 2 )   206 - 213   2019.2

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    DOI: 10.1007/s12185-018-02572-z

  • A nationwide survey on tracheostomy for very-low-birth-weight infants in Japan Reviewed

    , Hiroaki Kurata, Masayuki Ochiai, Hirosuke Inoue, Masako Ichiyama, Kazuaki Yasuoka, Junko Fujiyoshi, Yuki Matsushita, Satoshi Honjo, Yasunari Sakai, Shoichi Ohga

    Pediatric Pulmonology   54 ( 1 )   53 - 60   2019.1

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    DOI: 10.1002/ppul.24200

  • Positive effect of exogenous brain-derived neurotrophic factor on impaired neurite development and mitochondrial function in dopaminergic neurons derived from dental pulp stem cells from children with attention deficit hyperactivity disorder Reviewed

    Huong Thi Nguyen Nguyen, Hiroki Kato, Hiroshi Sato, Haruyoshi Yamaza, Yasunari Sakai, Shoichi Ohga, Kazuaki Nonaka, Keiji Masuda

    Biochemical and Biophysical Research Communications   2019.1

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    DOI: 10.1016/j.bbrc.2019.04.084

  • High incidence of ductal closure or narrowing at birth in patients with right ventricular outflow tract obstruction with normal orientation of the ductus arteriosus Reviewed

    Hazumu Nagata, Eiko Terashi, Mamoru Muraoka, Kiyoshi Uike, Yuichiro Hirata, Hideki Tatewaki, Yasuyuki Fujita, Kenichiro Yamamura, Shoichi Ohga

    Cardiology in the Young   29 ( 1 )   54 - 58   2019.1

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    DOI: 10.1017/S1047951118001798

  • Hemorrhagic Pneumonia as the First Manifestation of Anhidrotic Ectodermal Dysplasia with Immunodeficiency Reviewed

    Yuko Shono, Motoshi Sonoda, masataka ishimura, Shunsuke Kanno, Shoichi Ohga

    Journal of Clinical Immunology   2019.1

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    DOI: 10.1007/s10875-019-00626-3

  • Epstein-Barr virus-associated γδ T-cell lymphoproliferative disorder associated with hypomorphic IL2RG mutation Reviewed

    7 ( FEB )   2019.1

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    Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoproliferative syndrome, which is confirmed to have vulnerability to EBV infection. In contrast, EBV infects T cells (CD4+ T, CD8+ T, and γδT) or NK cells mono- or oligoclonally in CAEBV patients. It is known that the CAEBV phenotypes differ depending on which cells are infected with EBV. CAEBV is postulated to be associated with a genetic immunological abnormality, although its cause remains undefined. Here we describe a case of EBV-related γδT-cell proliferation with underlying hypomorphic IL2RG mutation. The immunological phenotype consisted of γδT-cell proliferation in the peripheral blood. A presence of EBV-infected B cells and γδT cells mimicked γδT-cell-type CAEBV. Although the patient had normal expression of CD132 (common γ chain), the phosphorylation of STAT was partially defective, indicating impaired activation of the downstream signal of the JAK/STAT pathway. Although the patient was not diagnosed as having CAEBV, this observation shows that CAEBV might be associated with immunological abnormality.

    DOI: 10.3389/fped.2019.00015

  • Early Intervention With Adrenocorticotropin for Acute Encephalopathy-Associated Epileptic Spasms Report of Two Cases Reviewed

    Kousuke Yonemoto, Yuko Shono, Masafumi Sanefuji, Noriyuki Kaku, Ayumi Sakata, Rieko Baba, Fumiya Yamashita, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Yoshihiko Maehara, Yasunari Sakai, Shoichi Ohga

    Clinical EEG and Neuroscience   50 ( 1 )   51 - 55   2019.1

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    DOI: 10.1177/1550059418786381

  • A rightward saccade to an unexpected stimulus as a marker for lateralised visuospatial attention Reviewed

    Masafumi Sanefuji, Hiroshi Yamashita, Michiko Torio, Daisuke Katsuki, Satoshi Akamine, Yoshito Ishizaki, Junji Kishimoto, Yasunari Sakai, Hidetoshi Takada, Keiko Yoshida, Shoichi Ohga

    Scientific reports   8 ( 1 )   2018.12

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    DOI: 10.1038/s41598-018-25890-y

  • Neurodevelopmental Outcomes in Infants With Birth Weight ≤500 g at 3 Years of Age. Reviewed International journal

    142 ( 6 )   2018.12

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    OBJECTIVES: To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS: Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study population consisted of 460 children (56.7% of 811 surviving infants) who were evaluated at 36 to 42 months of age. Neurodevelopmental impairment (NDI) was defined as having cerebral palsy, visual impairment, hearing impairment, or a developmental quotient score of <70. RESULTS: The overall proportion of NDI was 59.1% (95% confidence interval [CI]: 54.6%-63.5%). The trend revealed no significant change during the study period. In a multivariate modified Poisson regression analysis, NDI was associated with severe intraventricular hemorrhage (adjusted risk ratio [RR]: 1.42; 95% CI: 1.19-1.68; P < .01), cystic periventricular leukomalacia (adjusted RR: 1.40; 95% CI: 1.13-1.73; P < .01), severe necrotizing enterocolitis (adjusted RR: 1.31; 95% CI: 1.07-1.60; P < .01), surgical ligation for patent ductus arteriosus (adjusted RR: 1.29; 95% CI: 1.09-1.54; P < .01), and male sex (adjusted RR: 1.19; 95% CI: 1.01-2.40; P = .04). CONCLUSIONS: This cohort showed that neurodevelopmental outcomes of infants with a BW of ≤500 g have not improved from 2003 to 2012. Multivariate analysis revealed that severe intracranial hemorrhage and cystic periventricular leukomalacia were the strongest risk factors for NDIs. Our data suggested that measures aimed at reducing neurologic morbidities will be important for improving outcomes of infants with a BW of ≤500 g.

    DOI: 10.1542/peds.2017-4286

  • Vascular pathomechanism in acute encephalopathy with biphasic seizures and late reduced diffusion Reviewed

    Masafumi Sanefuji, Yuko Shono, Noriyuki Kaku, Momoko Sasazuki, Kosuke Yonemoto, Michiko Torio, Soichi Mizuguchi, Yoshitomo Motomura, Mamoru Muraoka, Sooyoung Lee, Haruhisa Baba, Kazuhiro Okubo, Yuri Sonoda, Yoshito Ishizaki, Yasunari Sakai, Shoichi Ohga

    Journal of the Neurological Sciences   395   141 - 146   2018.12

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    DOI: 10.1016/j.jns.2018.10.007

  • Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction The Japan Environment and Children's Study Reviewed

    Naho Morisaki, Chie Nagata, Shinobu Yasuo, Seiichi Morokuma, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Ayako Senju, Toshihiro Kawamoto, Shoichi Ohga, Koichi Kusuhara

    British Journal of Nutrition   120 ( 12 )   1432 - 1440   2018.12

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    DOI: 10.1017/S000711451800291X

  • Non-reassuring foetal status and neonatal irritability in the Japan Environment and Children’s Study A cohort study Reviewed

    8 ( 1 )   2018.12

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    The aim of this study was to investigate whether non-reassuring foetal status (NRFS) affected an infant’s temperament, or if the temperament formed prenatally resulted in an excessive heart rate reaction that was diagnosed as NRFS. We examined the correlation between NRFS and difficulty in holding a baby, and the amount of crying in the one month after birth, which was considered an indicator of the newborn’s temperament. We divided the cases with NRFS into positive NRFS and false positive NRFS. NRFS was associated with bad mood, frequent crying for a long duration, and intense crying. After adjustment for other covariates, NRFS was associated with bad mood (odds ratio, OR = 1.15, 95% confidence interval, CI = 1.00–1.33), and intense crying (1.12, 1.02–1.24). In the multi-variable model, positive and false positive NRFS were not clearly associated with neonatal irritability. When stratified by parity, NRFS and false positive NRFS were likely to be positively associated with neonatal irritability in parous women. The clear association between NRFS and intense crying was observed in parous women (multi-variable adjusted OR = 1.46, 95% CI = 1.16–1.83), but not in nulliparae (1.01, 0.91–1.12) (p for effect modification <0.01). Similarly, increased odds of intense crying associated with false positive NRFS were only found in parous women (multi-variable adjusted OR = 1.40, 95% CI = 1.09–1.81) (p for effect modification = 0.03). There was no association observed between positive NRFS and irritability; therefore, NRFS has no effect on an infant’s temperament.

    DOI: 10.1038/s41598-018-34231-y

  • Impaired neurite development associated with mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of children with autism spectrum disorder Reviewed

    Huong Thi Nguyen Nguyen, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Yuta Hirofuji, Hiroshi Sato, Thanh Thi Mai Pham, Fumiko Takayama, Yasunari Sakai, Shoichi Ohga, Tomoaki Taguchi, Kazuaki Nonaka

    Biochemistry and Biophysics Reports   16   24 - 31   2018.12

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    DOI: 10.1016/j.bbrep.2018.09.004

  • Burden of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Asthmatic Children Reviewed

    Takashi Furuta, Shunji Hasegawa, Makoto Mizutani, Takashi Iwai, Noriko Ohbuchi, Shoji Kawano, Norimichi Tashiro, Masashi Uchida, Masanari Hasegawa, Masashi Motoyama, Takaomi Sekino, Kenji Nakatsuka, Kiyoshi Ichihara, Komei Shirabe, Shoichi Ohga

    The Pediatric infectious disease journal   37 ( 11 )   1107 - 1111   2018.11

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    DOI: 10.1097/INF.0000000000002038

  • Radiotherapy for Langerhans cell histiocytosis with paraplegia A rare oncologic emergency case report in infancy and literature review Reviewed

    Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Ohga Saiji, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shoichi Ohga

    Brain and Development   40 ( 10 )   952 - 955   2018.11

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    DOI: 10.1016/j.braindev.2018.05.016

  • Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection Reviewed

    Takashi Imai, Takayuki Matsumura, Sabine Mayer-Lambertz, Christine A. Wells, Eri Ishikawa, Suzanne K. Butcher, Timothy C. Barnett, Mark J. Walker, Akihiro Imamura, Hideharu Ishida, Tadayoshi Ikebe, Tomofumi Miyamoto, Manabu Ato, Shoichi Ohga, Bernd Lepenies, Nina M. Van Sorge, Sho Yamasaki

    Proceedings of the National Academy of Sciences of the United States of America   115 ( 45 )   E10662 - E10671   2018.11

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    DOI: 10.1073/pnas.1809100115

  • Effective infliximab therapy for the early regression of coronary artery aneurysm in Kawasaki disease Reviewed

    Yusaku Nagatomo, Jun Muneuchi, Yasutaka Nakashima, Etsuro Nanishi, Hiromitsu Shirozu, Mamie Watanabe, Kiyoshi Uike, Hazumu Nagata, Yuichiro Hirata, Kenichiro Yamamura, Yasuhiko Takahashi, Seigo Okada, Yasuo Suzuki, Shunji Hasegawa, Shoichi Ohga

    International Journal of Cardiology   271   317 - 321   2018.11

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    DOI: 10.1016/j.ijcard.2018.04.062

  • Complement activation associated with ADAMTS13 deficiency may contribute to the characteristic glomerular manifestations in Upshaw-Schulman syndrome Reviewed

    Hiroe Itami, Shigeo Hara, Masanori Matsumoto, Shin Imamura, Rie Kanai, Kei Nishiyama, masataka ishimura, Shouichi Ohga, Makiko Yoshida, Ryojiro Tanaka, Yoshiyuki Ogawa, Yujiro Asada, Yoko Sekita-Hatakeyama, Kinta Hatakeyama, Chiho Ohbayashi

    Thrombosis Research   170   148 - 155   2018.10

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    DOI: 10.1016/j.thromres.2018.08.020

  • 髄膜炎における髄液中LRGの検討 Reviewed

    チョン・ピンフィー, 酒井 康成, 鳥巣 浩幸, 田中 珠美, 古野 憲司, 水野 由美, 原 寿郎, 大賀 正一, 吉良 龍太郎

    23 ( 2 )   211 - 211   2018.10

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  • A pediatric case with prostaglandin I2-associated thyrotoxicosis: Case report and the literature review. Reviewed

    Sonoda Y, Yamamura K, Ishii K, Ohkubo K, Ihara K, Sakai Y, Ohga S

    Journal of clinical research in pediatric endocrinology   11 ( 2 )   207 - 210   2018.10

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    A pediatric case with prostaglandin I2-associated thyrotoxicosis: Case report and the literature review.

    DOI: 10.4274/jcrpe.0169

  • Ocular findings in a case of Pierson syndrome with a novel mutation in laminin ß2 gene Reviewed

    22 ( 5 )   401 - 403.e1   2018.10

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    Pierson syndrome, an autosomal recessive disorder caused by a mutation in laminin ß2 (LAMB2) gene, is characterized by congenital nephrotic syndrome and various ocular abnormalities. The ocular findings in Pierson syndrome are not well understood, because the incidence of this syndrome is very rare. We report ocular findings in a 5-month-old boy with Pierson syndrome with a novel mutation in LAMB2. We performed a pupilloplasty for his microcoria. Ophthalmic examinations after surgery revealed that he had cataract, severe retinal degeneration, and high myopia. Optical coherence tomography showed the collapse of retinal layer structures and a marked decrease of choroidal thickness. Immunohistochemistry and electron microscopy examinations revealed abnormal iris differentiation and thinning or defect of basal membranes. These results suggest that the development of the iris, lens, retina, and choroid are affected in this type of mutation.

    DOI: 10.1016/j.jaapos.2018.03.016

  • Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells Reviewed

    67 ( 10 )   879 - 889   2018.10

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    Objective: IL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and generally acts as an activating signal. However, the role of LMP controlling NLRP3 inflammasome activation in human vascular smooth muscle cells (hVSMCs) is not well defined. Methods: LMP was induced in hVSMCs by Leu-Leu-O-methyl ester. Cathepsin B was inhibited by CA-074 Me. Cytokine release, mRNA, and protein were quantified by enzyme-linked immunosorbent assay, quantitative PCR, and Western blot, respectively. NF-κB activity was analyzed by immunostaining of the NF-κB p65 nuclear translocation and using the dual-luciferase reporter assay system. Results: LMP had both priming and activating roles, causing an upregulation of proIL-1β and NLRP3 and the secretion of mature IL-1β from unprimed hVSMCs. LMP activated the canonical NF-κB pathway. The priming effect of LMP was inhibited by CA-074 Me, indicating an upstream role of cathepsin B. Conclusions: These data support a novel role of LMP as a single stimulus for the secretion of IL-1β from hVSMCs, implying the possibility that hVSMCs are an important initiator of the sterile inflammatory response caused by lysosomal disintegration.

    DOI: 10.1007/s00011-018-1178-z

  • Diagnostic potential of stored dried blood spots for inborn errors of metabolism A metabolic autopsy of medium-chain acyl-CoA dehydrogenase deficiency Reviewed

    Noriyuki Kaku, Kenji Ihara, Yuichiro Hirata, Kenji Yamada, Sooyoung Lee, Hikaru Kanemasa, Yoshitomo Motomura, Haruhisa Baba, Tamami Tanaka, Yasunari Sakai, Yoshihiko Maehara, Shoichi Ohga

    Journal of Clinical Pathology   71 ( 10 )   885 - 889   2018.10

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    DOI: 10.1136/jclinpath-2017-204962

  • De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome Reviewed

    Tsutomu Toki, Kenichi Yoshida, Ru Nan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C. Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shoichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito

    American journal of human genetics   103 ( 3 )   440 - 447   2018.9

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    DOI: 10.1016/j.ajhg.2018.07.020

  • De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. Reviewed International journal

    Tsutomu Toki, Kenichi Yoshida, RuNan Wang, Sou Nakamura, Takanobu Maekawa, Kumiko Goi, Megumi C Katoh, Seiya Mizuno, Fumihiro Sugiyama, Rika Kanezaki, Tamayo Uechi, Yukari Nakajima, Yusuke Sato, Yusuke Okuno, Aiko Sato-Otsubo, Yusuke Shiozawa, Keisuke Kataoka, Yuichi Shiraishi, Masashi Sanada, Kenichi Chiba, Hiroko Tanaka, Kiminori Terui, Tomohiko Sato, Takuya Kamio, Hirotoshi Sakaguchi, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Hitoshi Kanno, Satoru Miyano, Seiji Kojima, Akira Ishiguro, Kanji Sugita, Naoya Kenmochi, Satoru Takahashi, Koji Eto, Seishi Ogawa, Etsuro Ito

    American journal of human genetics   103 ( 3 )   440 - 447   2018.9

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    DOI: 10.1016/j.ajhg.2018.07.020

  • Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis. Reviewed

    Pediatr Neonatol   https://doi.org/10.1016/j.pedn   2018.9

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    Chemokine levels predict progressive liver disease in Down syndrome patients with transient abnormal myelopoiesis.

  • A nationwide survey of pediatric-onset Japanese encephalitis in Japan. Reviewed

    Nanishi E, Hoshina T, Sanefuji M, Kadoya R, Kitazawa K, Arahata Y, Sato T, Hirayama Y, Hirai K, Yanai M, Nikaido K, Maeda A, Torisu H, Okada K, Sakai Y, Ohga S

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America   2018.9

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    A nationwide survey of pediatric-onset Japanese encephalitis in Japan.

    DOI: 10.1093/cid/ciy816

  • The Japanese Immune Tolerance Induction (J-ITI) study in haemophilia patients with inhibitor Outcomes and successful predictors of ITI treatment Reviewed

    K. Nogami, M. Taki, T. Matsushita, Shoichi Ohga, T. Oka, Y. Horikoshi, K. Amano, M. Shima

    Haemophilia   24 ( 5 )   e328 - e337   2018.9

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    DOI: 10.1111/hae.13531

  • Leucine-rich alpha-2 glycoprotein in the cerebrospinal fluid is a potential inflammatory biomarker for meningitis Reviewed

    Pin Fee Chong, Yasunari Sakai, Hiroyuki Torisu, Tamami Tanaka, Kenji Furuno, Yumi Mizuno, Shoichi Ohga, Toshiro Hara, Ryutaro Kira

    Journal of the Neurological Sciences   392   51 - 55   2018.9

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    DOI: 10.1016/j.jns.2018.07.006

  • A male case with CDKL5-associated encephalopathy manifesting transient methylmalonic acidemia Reviewed

    Satoshi Akamine, Yoshito Ishizaki, Yasunari Sakai, Hiroyuki Torisu, Ryoko Fukai, Noriko Miyake, Kazuhiro Okubo, Hiroshi Koga, Masafumi Sanefuji, Ayumi Sakata, Masahiko Kimura, Seiji Yamaguchi, Osamu Sakamoto, Toshiro Hara, Hirotomo Saitsu, Naomichi Matsumoto, Shouichi Ohga

    European Journal of Medical Genetics   61 ( 8 )   451 - 454   2018.8

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    DOI: 10.1016/j.ejmg.2018.03.003

  • Pediatric ganglioglioma with an H3 K27M mutation arising from the cervical spinal cord Reviewed

    Tomohiro Okuda, Nobuhiro Hata, Satoshi O. Suzuki, Koji Yoshimoto, Koichi Arimura, Takeo Amemiya, Yojiro Akagi, Daisuke Kuga, Utako Oba, Yuhki Koga, Shouichi Ohga, Toru Iwaki, Koji Iihara

    Neuropathology   38 ( 4 )   422 - 427   2018.8

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    DOI: 10.1111/neup.12471

  • Correction to: Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia. Reviewed

    Sonoda M, Ishimura M, Ichimiya Y, Terashi E, Eguchi K, Sakai Y, Takada H, Hama A, Kanno H, Toki T, Ito E, Ohga S

    International journal of hematology   108 ( 2 )   236   2018.8

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    Correction to: Atypical erythroblastosis in a patient with Diamond-Blackfan anemia who developed del(20q) myelodysplasia.

    DOI: 10.1007/s12185-018-2493-4

  • The efficacy of serum brain natriuretic peptide for the early detection of portopulmonary hypertension in biliary atresia patients before liver transplantation Reviewed

    Koichiro Yoshimaru, Toshiharu Matsuura, Yoshiaki Takahashi, Yusuke Yanagi, Hazumu Nagata, Shoichi Ohga, Tomoaki Taguchi

    Pediatric Transplantation   22 ( 5 )   2018.8

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    DOI: 10.1111/petr.13203

  • Reappraising newborn screening for cobalamin C disorder Reviewed

    Vlad Tocan, Kazuhiro Okubo, Kanako Higashi, Naoko Toda, Kanako Kojima-Ishii, Kei Nishiyama, masataka ishimura, Hidetoshi Takada, Osamu Sakamoto, Fusako Sasaki, Kazuko Yoshimura, Shinichi Hirose, Shoichi Ohga

    Pediatrics and Neonatology   59 ( 4 )   415 - 417   2018.8

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    DOI: 10.1016/j.pedneo.2017.11.002

  • Letter to ‘Pregnancy and delivery outcomes from patients with repaired anomalous origin of the left coronary artery from the pulmonary artery’ Reviewed

    44 ( 8 )   2018.8

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    DOI: 10.1111/jog.13673

  • Correction to Atypical erythroblastosis in a patient with Diamond–Blackfan anemia who developed del(20q) myelodysplasia Reviewed

    108 ( 2 )   2018.8

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    The corresponding author should be ‘‘Masataka Ishimura’’, and not ‘‘Motoshi Sonoda’’ as given in the original publication of the article.

    DOI: 10.1007/s12185-018-2493-4

  • Atypical erythroblastosis in a patient with Diamond–Blackfan anemia who developed del(20q) myelodysplasia Reviewed

    108 ( 2 )   228 - 231   2018.8

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    Diamond–Blackfan anemia (DBA) is a congenital red cell aplasia arising from ribosomal protein (RP) defects. Affected patients present with neonatal anemia, occasional dysmorphism, and cancer predisposition. An anemic newborn was diagnosed with DBA due to RPL5 mutation (c.473_474del, p.K158SfsX26). Refractory anemia required regular transfusions and iron chelation therapy. Pancytopenia occurred at age 16 years. Bone-marrow studies showed myelodysplasia, erythroblastosis, and clonal evolution of del(20)(q11.2q13.3). Severe anemia required transfusions. Del(20q), including the L3MBTL1 gene, is reported to be relevant to the hematological phenotype of Shwachman–Diamond syndrome. A combined defect of RPL5 and L3MBTL1 may contribute to the aberrant erythropoiesis in the present case.

    DOI: 10.1007/s12185-018-2424-4

  • Nontuberculous mycobacteria-associated hemophagocytic lymphohistiocytosis in MonoMAC syndrome Reviewed

    Katsuhide Eguchi, masataka ishimura, Motoshi Sonoda, Hiroki Ono, Akira Shiraishi, Shunsuke Kanno, Yuhki Koga, Hidetoshi Takada, Shoichi Ohga

    Pediatric Blood and Cancer   65 ( 7 )   2018.7

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    DOI: 10.1002/pbc.27017

  • Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection. Reviewed

    Okuzono S, Ishimura M, Kanno S, Sonoda M, Kaku N, Motomura Y, Nishio H, Oba U, Hanada M, Fukushi JI, Urata M, Kang D, Takada H, Ohga S

    Annals of clinical microbiology and antimicrobials   17 ( 1 )   31   2018.7

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    Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection.

    DOI: 10.1186/s12941-018-0282-9

  • Cancer Management in Kabuki Syndrome: The First Case of Wilms Tumor and a Literature Review. Reviewed

    Teranishi H, Koga Y, Nakashima K, Morihana E, Ishii K, Sakai Y, Taguchi T, Oda Y, Miyake N, Matsumoto N, Ohga S

    Journal of pediatric hematology/oncology   40 ( 5 )   391 - 394   2018.7

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    Cancer Management in Kabuki Syndrome: The First Case of Wilms Tumor and a Literature Review.

    DOI: 10.1097/MPH.0000000000001111

  • Predictive indicators for the development of epilepsy after acute encephalopathy with biphasic seizures and late reduced diffusion Reviewed

    Yuko Shono, Noriyuki Kaku, Masafumi Sanefuji, Michiko Torio, Soichi Mizuguchi, Yoshitomo Motomura, Mamoru Muraoka, Sooyoung Lee, Haruhisa Baba, Yuri Sonoda, Yoshito Ishizaki, Momoko Sasazuki, Yasunari Sakai, Yoshihiko Maehara, Shoichi Ohga

    Epilepsy Research   143   70 - 74   2018.7

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    DOI: 10.1016/j.eplepsyres.2018.04.006

  • Survey of anticancer drug exposure to attendant families in pediatric medical centers Reviewed

    Yuko Noda, Yuhki Koga, Momoe Ohta, Mami Miyazono, Yoko Wakasugi, Yukie Funakoshi, Yuki Urabe, Miho Kifune, Tamaki Ueda, Utako Oba, Kentaro Nakashima, Ryota Sozaki, Yoshiaki Kinoshita, Tomoaki Taguchi, Shoichi Ohga

    Japanese Journal of Cancer and Chemotherapy   45 ( 6 )   945 - 948   2018.6

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  • Effective shunt closure for pulmonary hypertension and liver dysfunction in congenital portosystemic venous shunt Reviewed

    Kiyoshi Uike, Hazumu Nagata, Yuichiro Hirata, Kenichiro Yamamura, Eiko Terashi, Toshiharu Matsuura, Eiji Morihana, Kazuhiro Okubo, Kanako Ishii, Yasunari Sakai, Tomoaki Taguchi, Shoichi Ohga

    Pediatric Pulmonology   53 ( 4 )   505 - 511   2018.4

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/ppul.23944

  • Fever and Skin Involvement at Diagnosis Predicting the Intractable Langerhans Cell Histiocytosis: 40 Case-Series in a Single Center. Reviewed

    Kobayashi T, Koga Y, Ishimura M, Nakashima K, Kato W, Ono H, Sonoda M, Eguchi K, Fukano R, Honjo S, Oda Y, Ohga S

    Journal of pediatric hematology/oncology   40 ( 3 )   e148 - e153   2018.4

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    Fever and Skin Involvement at Diagnosis Predicting the Intractable Langerhans Cell Histiocytosis: 40 Case-Series in a Single Center.

    DOI: 10.1097/MPH.0000000000001080

  • Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome Reviewed

    Eiji Morihana, Kenichiro Yamamura, Yuichiro Sugitani, Hideaki Kado, Yasushi Takahata, Toshihide Nakano, Yasutaka Nakashima, Naoki Fusazaki, Shoichi Ohga

    Pediatric Cardiology   39 ( 4 )   749 - 756   2018.4

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    DOI: 10.1007/s00246-018-1815-x

  • Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome Reviewed

    Saki Hirofuji, Yuta Hirofuji, Hiroki Kato, Keiji Masuda, Haruyoshi Yamaza, Hiroshi Sato, Fumiko Takayama, Michiko Torio, Yasunari Sakai, Shoichi Ohga, Tomoaki Taguchi, Kazuaki Nonaka

    Biochemical and Biophysical Research Communications   498 ( 4 )   898 - 904   2018.4

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    DOI: 10.1016/j.bbrc.2018.03.077

  • Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2. Reviewed

    Akamine S, Sagata N, Sakai Y, Kato TA, Nakahara T, Matsushita Y, Togao O, Hiwatashi A, Sanefuji M, Ishizaki Y, Torisu H, Saitsu H, Matsumoto N, Hara T, Sawa A, Kano S, Furue M, Kanba S, Shaw CA, Ohga S

    Epilepsia open   3 ( 1 )   81 - 85   2018.3

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    Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in NF1 and MAGEL2.

    DOI: 10.1002/epi4.12085

  • Histopathological and genetic review of phosphaturic mesenchymal tumours, mixed connective tissue variant. Reviewed International journal

    Yuichi Yamada, Izumi Kinoshita, Kohashi Kenichi, Hidetaka Yamamoto, Takeshi Iwasaki, Hiroshi Otsuka, Masato Yoshimoto, Shin Ishihara, Yu Toda, Yuki Kuma, Nokitaka Setsu, Yuki Koga, Yumi Honda, Takeshi Inoue, Hiroyuki Yanai, Kyoko Yamashita, Ichiro Ito, Mitsuru Takahashi, Shouichi Ohga, Masutaka Furue, Yasuharu Nakashima, Yoshinao Oda

    Histopathology   72 ( 3 )   460 - 471   2018.2

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    DOI: 10.1111/his.13377

  • Thrombotic microangiopathy in a very young infant with mitral valvuloplasty. Reviewed

    Matsunaga Y, Ishimura M, Nagata H, Uike K, Kinjo T, Ochiai M, Yamamura K, Takada H, Tanoue Y, Hayakawa M, Matsumoto M, Hara T, Ohga S

    Pediatrics and neonatology   2018.2

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    Thrombotic microangiopathy in a very young infant with mitral valvuloplasty.

    DOI: 10.1016/j.pedneo.2018.02.002

  • Integrative Analyses of De Novo Mutations Provide Deeper Biological Insights into Autism Spectrum Disorder. Cell Rep. Reviewed International journal

    Takata A, Miyake N, Tsurusaki Y, Fukai R, Miyatake S, Koshimizu E, Kushima I, Okada T, Morikawa M, Uno Y, Ishizuka K, Nakamura K, Tsujii M, Yoshikawa T, Toyota T, Okamoto N, Hiraki Y, Hashimoto R, Yasuda Y, Saitoh S, Ohashi K, Sakai Y, Ohga S, Hara T, Kato M, Nakamura K, Ito A, Seiwa C, Shirahata E, Osaka H, Matsumoto A, Takeshita S, Tohyama J, Saikusa T, Matsuishi T, Nakamura T, Tsuboi T, Kato T, Suzuki T, Saitsu H, Nakashima M, Mizuguchi T, Tanaka F, Mori N, Ozaki N, Matsumoto N.

    Cell Rep   22 ( 3 )   734 - 747   2018.1

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  • Distinctive inflammatory profile between acute focal bacterial nephritis and acute pyelonephritis in children Reviewed

    Makoto Mizutani, Shunji Hasegawa, Takeshi Matsushige, Naoki Ohta, Setsuaki Kittaka, Madoka Hoshide, Takeshi Kusuda, Kazumasa Takahashi, Kiyoshi Ichihara, Shouichi Ohga

    CYTOKINE   99   24 - 29   2017.11

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    DOI: 10.1016/j.cyto.2017.06.012

  • Early Mortality and Morbidity in Infants with Birth Weight of 500 Grams or Less in Japan Reviewed

    Hirosuke Inoue, Masayuki Ochiai, Kazuaki Yasuoka, Koichi Tanaka, Hiroaki Kurata, Junko Fujiyoshi, Yuki Matsushita, Shutaro Suga, Kazuaki Nonaka, Tomoaki Taguchi, Kiyoko Kato, Shouichi Ohga

    JOURNAL OF PEDIATRICS   190   112 - +   2017.11

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    DOI: 10.1016/j.jpeds.2017.05.017

  • Calcineurin inhibitors exacerbate coronary arteritis via the MyD88 signalling pathway in a murine model of Kawasaki disease Reviewed

    K. Murata, Y. Motomura, T. Tanaka, S. Kanno, T. Yano, M. Onimaru, A. Shimoyama, H. Nishio, Y. Sakai, M. Oh-Hora, H. Hara, K. Fukase, H. Takada, S. Masuda, S. Ohga, S. Yamasaki, T. Hara

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   190 ( 1 )   54 - 67   2017.10

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    DOI: 10.1111/cei.13002

  • Sustained endocrine profiles of a girl with WAGR syndrome Reviewed

    Yui Takada, Yasunari Sakai, Yuki Matsushita, Kazuhiro Ohkubo, Yuhki Koga, Satoshi Akamine, Michiko Torio, Yoshito Ishizaki, Masafumi Sanefuji, Hiroyuki Torisu, Chad A. Shaw, Masayo Kagami, Toshiro Hara, Shouichi Ohga

    BMC MEDICAL GENETICS   18 ( 1 )   117 - 117   2017.10

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    DOI: 10.1186/s12881-017-0477-5

  • Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study Reviewed

    Noriaki Sagata, Takahiro A. Kato, Shin-ichi Kano, Masahiro Ohgidani, Norihiro Shimokawa, Mina Sato-Kasai, Kohei Hayakawa, Nobuki Kuwano, Ashley M. Wilson, Koko Ishizuka, Shiori Kato, Takeshi Nakahara, Makiko Nakahara-Kido, Daiki Setoyama, Yasunari Sakai, Shouichi Ohga, Masutaka Furue, Akira Sawa, Shigenobu Kanba

    SCIENTIFIC REPORTS   7 ( 1 )   13905   2017.10

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    DOI: 10.1038/s41598-017-14440-7

  • Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection. Reviewed

    Fujimoto Y, Hasegawa S, Matsushige T, Wakiguchi H, Nakamura T, Hasegawa H, Nakajima N, Ainai A, Oga A, Itoh H, Shirabe K, Toda S, Atsuta R, Morishima T, Ohga S

    Scientific reports   7 ( 1 )   9128   2017.8

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    Pulmonary inflammation and cytokine dynamics of bronchoalveolar lavage fluid from a mouse model of bronchial asthma during A(H1N1)pdm09 influenza infection.

    DOI: 10.1038/s41598-017-08030-w

  • Transient dysautonomia in an acute phase of encephalopathy with biphasic seizures and late reduced diffusion Reviewed

    Yuko Ichimiya, Noriyuki Kaku, Yasunari Sakai, Fumiya Yamashita, Wakato Matsuoka, Mamoru Muraoka, Satoshi Akamine, Soiai Mizuguchi, Michiko Torio, Yoshitomo Motomura, Yuichiro Hirata, Yoshito Ishizaki, Masafumi Sanefuji, Hiroyuki Torisu, Hidetoshi Takada, Yoshihiko Maehara, Shouichi Ohga

    BRAIN & DEVELOPMENT   39 ( 7 )   621 - 624   2017.8

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    DOI: 10.1016/j.braindev.2017.03.023

  • Toxic epidermal necrolysis in a child 6 months post-hematopoietic stem cell transplantation Reviewed

    Utako Oba, Hiroshi Yamada, So-ichi Suenobu, Yusuke Nakamura, Akiko Ito, Yutaka Hatano, Nobuyoshi Itonaga, Kouichi Ohshima, Yuhki Koga, Shouichi Ohga, Kenji Ihara

    PEDIATRIC TRANSPLANTATION   21 ( 5 )   2017.8

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    DOI: 10.1111/petr.12931

  • The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene Invited Reviewed International journal

    Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   64 ( 7 )   2017.7

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    DOI: 10.1002/pbc.26404

  • The clinical presentation and genotype of protein C deficiency with double mutations of the protein C gene Reviewed

    Hirofumi Inoue, Shin-ichi Terachi, Takeshi Uchiumi, Tetsuji Sato, Michiyo Urata, Masataka Ishimura, Yui Koga, Taeko Hotta, Toshiro Hara, Dongchon Kang, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   64 ( 7 )   2017.7

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    DOI: 10.1002/pbc.26404

  • Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes Reviewed

    Hideki Muramatsu, Yusuke Okuno, Kenichi Yoshida, Yuichi Shiraishi, Sayoko Doisaki, Atsushi Narita, Hirotoshi Sakaguchi, Nozomu Kawashima, Xinan Wang, Yinyan Xu, Kenichi Chiba, Hiroko Tanaka, Asahito Hama, Masashi Sanada, Yoshiyuki Takahashi, Hitoshi Kanno, Hiroki Yamaguchi, Shouichi Ohga, Atsushi Manabe, Hideo Harigae, Shinji Kunishima, Eiichi Ishii, Masao Kobayashi, Kenichi Koike, Kenichiro Watanabe, Etsuro Ito, Minoru Takata, Miharu Yabe, Seishi Ogawa, Satoru Miyano, Seiji Kojima

    GENETICS IN MEDICINE   19 ( 7 )   796 - 802   2017.7

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    DOI: 10.1038/gim.2016.197

  • Abnormal hematopoiesis and autoimmunity in human subjects with germline IKZF1 mutations Reviewed

    Akihiro Hoshino, Satoshi Okada, Kenichi Yoshida, Naonori Nishida, Yusuke Okuno, Hiroo Ueno, Motoi Yamashita, Tsubasa Okano, Miyuki Tsumura, Shiho Nishimura, Sonoko Sakata, Masao Kobayashi, Haruna Nakamura, Junji Kamizono, Kanako Mitsui-Sekinaka, Takuya Ichimura, Shouichi Ohga, Yozo Nakazawa, Masatoshi Takagi, Kohsuke Imai, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Shigeaki Nonoyama, Tomohiro Morio, Hirokazu Kanegane

    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   140 ( 1 )   223 - 231   2017.7

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    DOI: 10.1016/j.jaci.2016.09.029

  • Diagnostic challenge of Diamond-Blackfan anemia in mothers and children by whole-exome sequencing Invited Reviewed International journal

    Shouichi Ohga

    INTERNATIONAL JOURNAL OF HEMATOLOGY   105 ( 4 )   515 - 520   2017.4

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    DOI: 10.1007/s12185-016-2151-7

  • Intramuscular Venous Malformation in an Infant Masquerading as Recurrent Gonarthritis Reviewed

    Etsuro Nanishi, Takayuki Hoshina, Hisanori Nishio, Murasaki Aman, Akio Sakamoto, Shouichi Ohga, Toshiro Hara

    PEDIATRICS AND NEONATOLOGY   58 ( 2 )   185 - 186   2017.4

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    DOI: 10.1016/j.pedneo.2015.10.013

  • Intractable Back Pain After Coil Embolization of Giant Veno-Venous Collaterals in a Patient With Fontan Circulation. Reviewed

    Okada S, Kamada M, Nakagawa N, Ishiguchi Y, Moritoh Y, Shohi M, Okamoto K, Hasegawa S, Ohga S

    International heart journal   58 ( 2 )   298 - 301   2017.4

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    Intractable Back Pain After Coil Embolization of Giant Veno-Venous Collaterals in a Patient With Fontan Circulation.

    DOI: 10.1536/ihj.16-194

  • Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia Invited Reviewed International journal

    Shouichi Ohga

    HAEMATOLOGICA   102 ( 3 )   E93 - E96   2017.3

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    DOI: 10.3324/haematol.2016.153932

  • Exome sequencing identified RPS15A as a novel causative gene for Diamond-Blackfan anemia Reviewed

    Fumika Ikeda, Kenichi Yoshida, Tsutomu Toki, Tamayo Uechi, Shiori Ishida, Yukari Nakajima, Yoji Sasahara, Yusuke Okuno, Rika Kanezaki, Kiminori Terui, Takuya Kamio, Akie Kobayashi, Takashi Fujita, Aiko Sato-Otsubo, Yuichi Shiraishi, Hiroko Tanaka, Kenichi Chiba, Hideki Muramatsu, Hitoshi Kanno, Shouichi Ohga, Akira Ohara, Seiji Kojima, Naoya Kenmochi, Satoru Miyano, Seishi Ogawa, Etsuro Ito

    HAEMATOLOGICA   102 ( 3 )   E93 - E96   2017.3

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    DOI: 10.3324/haematol.2016.153932

  • Activated phosphoinositide 3-kinase δ syndrome presenting with gut-associated T-cell lymphoproliferative disease. Reviewed

    Teranishi, H, Ishimura, M, Koga, Y, Eguchi, K, Sonoda, M, Kobayashi, T, Shiraishi, S, Nakashima, K, Ikegami, K, Aman, M, Yamamoto, H, 高田, 英俊, Ohga, S

    58 ( 1 )   20 - 25   2017.1

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    DOI: 10.11406/rinketsu.58.20

  • Involuntary movements and coma as the prognostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion Invited Reviewed International journal

    Shouichi Ohga

    JOURNAL OF THE NEUROLOGICAL SCIENCES   370   39 - 43   2016.11

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    DOI: 10.1016/j.jns.2016.09.018

  • Two infants with tuberculid associated with Kawasaki disease. Reviewed

    Yamada H, Ohta H, Hasegawa S, Azuma Y, Hasegawa M, Kadoya R, Ohbuchi N, Ohnishi Y, Okada S, Hoshide M, Ohga S

    Human vaccines & immunotherapeutics   12 ( 11 )   2772 - 2776   2016.11

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    Two infants with tuberculid associated with Kawasaki disease.

    DOI: 10.1080/21645515.2016.1208329

  • Involuntary movements and coma as the prognostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion. Reviewed

    Lee S, Sanefuji M, Torio M, Kaku N, Ichimiya Y, Mizuguchi S, Baba H, Sakai Y, Ishizaki Y, Torisu H, Kira R, Hara T, Ohga S

    Journal of the neurological sciences   370   39 - 43   2016.11

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    Involuntary movements and coma as the prognostic marker for acute encephalopathy with biphasic seizures and late reduced diffusion.

    DOI: 10.1016/j.jns.2016.09.018

  • A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases. Reviewed

    Nanishi E, Hoshina T, Takada H, Ishimura M, Nishio H, Uehara T, Mizuno Y, Hasegawa S, Ohga S, Nagao M, Igarashi M, Yajima S, Kusumoto Y, Onishi N, Sasahara Y, Yasumi T, Heike T, Hara T, PID-Infection Study Group

    The Journal of infection   73 ( 4 )   358 - 368   2016.10

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    A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency diseases.

    DOI: 10.1016/j.jinf.2016.07.018

  • JAK2, MPL, and CALR mutations in children with essential thrombocythemia Invited Reviewed International journal

    Shouichi Ohga

    INTERNATIONAL JOURNAL OF HEMATOLOGY   104 ( 2 )   266 - 267   2016.8

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    DOI: 10.1007/s12185-016-2022-2

  • JAK2, MPL, and CALR mutations in children with essential thrombocythemia. Reviewed

    Sekiya Y, Okuno Y, Muramatsu H, Ismael O, Kawashima N, Narita A, Wang X, Xu Y, Hama A, Fujisaki H, Imamura T, Hasegawa D, Kosaka Y, Sunami S, Ohtsuka Y, Ohga S, Takahashi Y, Kojima S, Shimada A

    International journal of hematology   104 ( 2 )   266-7   2016.8

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    JAK2, MPL, and CALR mutations in children with essential thrombocythemia.

    DOI: 10.1007/s12185-016-2022-2

  • Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan Invited Reviewed International journal

    Shouichi Ohga

    PLOS ONE   11 ( 8 )   2016.8

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    DOI: 10.1371/journal.pone.0161439

  • SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7 Invited Reviewed International journal

    Shouichi Ohga

    NATURE GENETICS   48 ( 7 )   792 - +   2016.7

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    DOI: 10.1038/ng.3569

  • SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7. Reviewed

    Narumi S, Amano N, Ishii T, Katsumata N, Muroya K, Adachi M, Toyoshima K, Tanaka Y, Fukuzawa R, Miyako K, Kinjo S, Ohga S, Ihara K, Inoue H, Kinjo T, Hara T, Kohno M, Yamada S, Urano H, Kitagawa Y, Tsugawa K, Higa A, Miyawaki M, Okutani T, Kizaki Z, Hamada H, Kihara M, Shiga K, Yamaguchi T, Kenmochi M, Kitajima H, Fukami M, Shimizu A, Kudoh J, Shibata S, Okano H, Miyake N, Matsumoto N, Hasegawa T

    Nature genetics   48 ( 7 )   792 - 797   2016.7

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    SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7.

    DOI: 10.1038/ng.3569

  • Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia. Reviewed

    Utsugisawa T, Uchiyama T, Toki T, Ogura H, Aoki T, Hamaguchi I, Ishiguro A, Ohara A, Kojima S, Ohga S, Ito E, Kanno H

    Blood cells, molecules & diseases   59   31 - 36   2016.7

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    Erythrocyte glutathione is a novel biomarker of Diamond-Blackfan anemia.

    DOI: 10.1016/j.bcmd.2016.03.007

  • Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin. Reviewed

    Kibata T, Suzuki Y, Hasegawa S, Matsushige T, Kusuda T, Hoshide M, Takahashi K, Okada S, Wakiguchi H, Moriwake T, Uchida M, Ohbuchi N, Iwai T, Hasegawa M, Ichihara K, Yashiro M, Makino N, Nakamura Y, Ohga S

    International journal of cardiology   214   209 - 215   2016.7

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    Coronary artery lesions and the increasing incidence of Kawasaki disease resistant to initial immunoglobulin.

    DOI: 10.1016/j.ijcard.2016.03.017

  • ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia. Reviewed

    Arashiki N, Takakuwa Y, Mohandas N, Hale J, Yoshida K, Ogura H, Utsugisawa T, Ohga S, Miyano S, Ogawa S, Kojima S, Kanno H

    Haematologica   101 ( 5 )   559 - 565   2016.5

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    ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.

    DOI: 10.3324/haematol.2016.142273

  • Adjunct cyclosporine therapy for refractory Kawasaki disease in a very young infant. Reviewed

    Okada S, Azuma Y, Suzuki Y, Yamada H, Wakabayashi-Takahara M, Korenaga Y, Akase H, Hasegawa S, Ohga S

    Pediatrics international : official journal of the Japan Pediatric Society   58 ( 4 )   295 - 298   2016.4

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    Adjunct cyclosporine therapy for refractory Kawasaki disease in a very young infant.

    DOI: 10.1111/ped.12778

  • Memory B-Cell Pools Predict the Immune Response to Pneumococcal Conjugate Vaccine in Immunocompromised Children. Invited Reviewed International journal

    Shouichi Ohga

    THE JOURNAL OF INFECTIOUS DISEASES   213 ( 5 )   848 - 855   2016.3

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    DOI: 10.1093/infdis/jiv469

  • A Sporadic Neonatal Case of Epidermolysis Bullosa Simplex Generalized Intermediate with KRT5 and KRT14 Gene Mutations. Reviewed

    Wakiguchi H, Hasegawa S, Maeba S, Kimura S, Ito S, Tateishi H, Ueda K, Ohga S

    AJP reports   6 ( 1 )   e108 - 11   2016.3

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    A Sporadic Neonatal Case of Epidermolysis Bullosa Simplex Generalized Intermediate with KRT5 and KRT14 Gene Mutations.

    DOI: 10.1055/s-0035-1570386

  • Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency Reviewed

    Masako Ichiyama, Shouichi Ohga, Masayuki Ochiai, Kotaro Fukushima, Masataka Ishimura, Michiko Torio, Michiyo Urata, Taeko Hotta, Dongchon Kang, Toshiro Hara

    BRAIN & DEVELOPMENT   38 ( 2 )   253 - 256   2016.2

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    DOI: 10.1016/j.braindev.2015.07.004

  • ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan. Reviewed

    Ikeda F, Toki T, Kanezaki R, Terui K, Yoshida K, Kanno H, Ohga S, Ohara A, Kojima S, Ogawa S, Ito E

    International journal of hematology   103 ( 1 )   112 - 114   2016.1

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    ALDH2 polymorphism in patients with Diamond-Blackfan anemia in Japan.

    DOI: 10.1007/s12185-015-1891-0

  • Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism Reviewed

    Masako Ichiyama, Shouichi Ohga, Masayuki Ochiai, Koichi Tanaka, Yuka Matsunaga, Takeshi Kusuda, Hirosuke Inoue, Masataka Ishimura, Tomohito Takimoto, Yui Koga, Taeko Hotta, Dongchon Kang, Toshiro Hara

    PEDIATRIC RESEARCH   79 ( 1 )   81 - 86   2016.1

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    DOI: 10.1038/pr.2015.180

  • Erratum to: Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis. Reviewed

    Doi T, Ohga S, Ishimura M, Takada H, Ishii K, Ihara K, Nagai H, Hara T

    European journal of pediatrics   174 ( 12 )   1701   2015.12

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    Erratum to: Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis.

    DOI: 10.1007/s00431-015-2638-x

  • Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine. Reviewed

    Hama A, Takahashi Y, Muramatsu H, Ito M, Narita A, Kosaka Y, Tsuchida M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S

    Haematologica   100 ( 11 )   1426 - 1433   2015.11

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    Comparison of long-term outcomes between children with aplastic anemia and refractory cytopenia of childhood who received immunosuppressive therapy with antithymocyte globulin and cyclosporine.

    DOI: 10.3324/haematol.2015.128553

  • Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels. Reviewed

    Wakiguchi H, Hasegawa S, Hirano R, Kaneyasu H, Wakabayashi-Takahara M, Ohga S

    Pediatric rheumatology online journal   13   49   2015.11

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    Successful control of juvenile dermatomyositis-associated macrophage activation syndrome and interstitial pneumonia: distinct kinetics of interleukin-6 and -18 levels.

    DOI: 10.1186/s12969-015-0048-2

  • Remission of autoimmune neutropenia after development of Kawasaki disease. Reviewed

    Okada S, Hasegawa S, Suzuki Y, Ichimura T, Kaneyasu H, Shimomura M, Wakabayashi-Takahara M, Nakamura K, Kobayashi M, Ohga S

    Pediatrics international : official journal of the Japan Pediatric Society   57 ( 5 )   1012 - 1014   2015.10

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    Remission of autoimmune neutropenia after development of Kawasaki disease.

    DOI: 10.1111/ped.12701

  • In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice. Reviewed

    Yamaza T, Alatas FS, Yuniartha R, Yamaza H, Fujiyoshi JK, Yanagi Y, Yoshimaru K, Hayashida M, Matsuura T, Aijima R, Ihara K, Ohga S, Shi S, Nonaka K, Taguchi T

    Stem cell research & therapy   6   171   2015.9

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    In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice.

    DOI: 10.1186/s13287-015-0154-6

  • Memory B-Cell Pools Predict the Immune Response to Pneumococcal Conjugate Vaccine in Immunocompromised Children

    Takayuki Hoshina, Shouichi Ohga, Junko Fujiyoshi, Etsuro Nanishi, Tomoko Takimoto, Shunsuke Kanno, Hisanori Nishio, Mitsumasa Saito, Yukihiro Akeda, Kazunori Oishi, Toshiro Hara

    The Journal of Infectious Diseases   213   848 - 855   2015.9

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    DOI: 10.1093/infdis/jiv469

  • Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia. Reviewed

    Narita A, Muramatsu H, Sekiya Y, Okuno Y, Sakaguchi H, Nishio N, Yoshida N, Wang X, Xu Y, Kawashima N, Doisaki S, Hama A, Takahashi Y, Kudo K, Moritake H, Kobayashi M, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S

    Haematologica   2015.8

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    Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia.

    DOI: 10.3324/haematol.2015.132530

  • Cat-scratch disease with severe pleuritis in a 6-year-old girl Reviewed

    Sasagu Kimura, Shunji Hasegawa, Masashi Yanagihara, Hirofumi Inoue, Takeshi Matsushige, Hidehiro Tsuneoka, Takashi Ichiyama, Shouichi Ohga

    PEDIATRICS INTERNATIONAL   57 ( 3 )   501 - 503   2015.6

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    DOI: 10.1111/ped.12680

  • Acute pericardial effusion representing the TNF-α-mediated severe inflammation but not the coronary artery outcome of Kawasaki disease. Reviewed

    44 ( 3 )   247 - 252   2015.5

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    DOI: 10.3109/03009742.2014.956140

  • Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia. Reviewed

    Wang R, Yoshida K, Toki T, Sawada T, Uechi T, Okuno Y, Sato-Otsubo A, Kudo K, Kamimaki I, Kanezaki R, Shiraishi Y, Chiba K, Tanaka H, Terui K, Sato T, Iribe Y, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Hara J, Goi K, Matsubara K, Koike K, Ishiguro A, Okamoto Y, Watanabe K, Kanno H, Kojima S, Miyano S, Kenmochi N, Ogawa S, Ito E

    British journal of haematology   168 ( 6 )   854 - 864   2015.3

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    Loss of function mutations in RPL27 and RPS27 identified by whole-exome sequencing in Diamond-Blackfan anaemia.

    DOI: 10.1111/bjh.13229

  • Drug reaction with eosinophilia and systemic symptoms during primary Epstein-Barr virus infection Reviewed

    Etsuro Nanishi, Takayuki Hoshina, Shouichi Ohga, Hisanori Nishio, Toshiro Hara

    JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION   48 ( 1 )   109 - 112   2015.2

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    DOI: 10.1016/j.jmii.2014.06.012

  • Early progression of atherosclerosis in children with chronic infantile neurological cutaneous and articular syndrome Reviewed

    Kenichiro Yamamura, Hidetoshi Takada, Kiyoshi Uike, Yasutaka Nakashima, Yuichiro Hirata, Hazumu Nagata, Tomohito Takimoto, Masataka Ishimura, Eiji Morihana, Shouichi Ohga, Toshiro Hara

    RHEUMATOLOGY   53 ( 10 )   1783 - 1787   2014.10

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    DOI: 10.1093/rheumatology/keu180

  • Successful treatment of non-Hodgkin's lymphoma using R-CHOP in a patient with Wiskott-Aldrich syndrome followed by a reduced-intensity stem cell transplant Reviewed

    Yuhki Koga, Hidetoshi Takada, Aiko Suminoe, Shouichi Ohga, Toshiro Hara

    PEDIATRIC TRANSPLANTATION   18 ( 6 )   E208 - E211   2014.9

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    DOI: 10.1111/petr.12297

  • Peripheral blood lymphocyte telomere length as a predictor of response to immunosuppressive therapy in childhood aplastic anemia. Reviewed

    Sakaguchi H, Nishio N, Hama A, Kawashima N, Wang X, Narita A, Doisaki S, Xu Y, Muramatsu H, Yoshida N, Takahashi Y, Kudo K, Moritake H, Nakamura K, Kobayashi R, Ito E, Yabe H, Ohga S, Ohara A, Kojima S, Japan Childhood, Aplastic Anemia, Study Group

    Haematologica   99 ( 8 )   1312 - 1316   2014.8

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    Peripheral blood lymphocyte telomere length as a predictor of response to immunosuppressive therapy in childhood aplastic anemia.

    DOI: 10.3324/haematol.2013.091165

  • Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood. Reviewed

    Hoshina T, Nakashima Y, Sato D, Nanishi E, Nishio H, Nagata H, Yamamura K, Doi T, Shiokawa Y, Koga Y, Kang D, Ohga S, Hara T

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   20 ( 2 )   128 - 130   2014.2

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    Staphylococcal endocarditis as the first manifestation of heritable protein S deficiency in childhood.

    DOI: 10.1016/j.jiac.2013.08.002

  • Neonatal hemophagocytic lymphohistiocytosis associated with a vertical transmission of coxsackievirus B1 Reviewed

    Mitsuharu Fukazawa, Takayuki Hoshina, Etsuro Nanishi, Hisanori Nishio, Takehiko Doi, Shouichi Ohga, Toshiro Hara

    JOURNAL OF INFECTION AND CHEMOTHERAPY   19 ( 6 )   1210 - 1213   2013.12

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    DOI: 10.1007/s10156-013-0629-2

  • Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis. Reviewed

    Doi T, Ohga S, Ishimura M, Takada H, Ishii K, Ihara K, Nagai H, Hara T

    European journal of pediatrics   172 ( 11 )   1475 - 1481   2013.11

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    Long-term liposteroid therapy for idiopathic pulmonary hemosiderosis.

    DOI: 10.1007/s00431-013-2065-9

  • Clinical characteristics and outcomes of chédiak-Higashi syndrome: a nationwide survey of Japan. Reviewed

    60 ( 10 )   1582 - 1586   2013.10

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    DOI: 10.1002/pbc.24637

  • Limited renal prophylaxis in regular plasmatherapy for heritable ADAMTS13 deficiency. Reviewed

    Doi T, Ohga S, Ito N, Ishimura M, Suga N, Nomura A, Takada H, Matsumoto M, Fujimura Y, Hara T

    Pediatric blood & cancer   60 ( 9 )   1557 - 1558   2013.9

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    Limited renal prophylaxis in regular plasmatherapy for heritable ADAMTS13 deficiency.

    DOI: 10.1002/pbc.24553

  • Thrombocytosis in asplenia syndrome with congenital heart disease: A previously unrecognized risk factor for thromboembolism Reviewed

    Kenichiro Yamamura, Kunitaka Joo, Shouichi Ohga, Hazumu Nagata, Kazuyuki Ikeda, Jun Muneuchi, Mamie Watanabe, Toshiro Hara

    INTERNATIONAL JOURNAL OF CARDIOLOGY   167 ( 5 )   2259 - 2263   2013.9

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    DOI: 10.1016/j.ijcard.2012.06.009

  • Bilateral stenosis of carotid siphon in Hutchinson-Gilford progeria syndrome. Reviewed

    Narazaki R, Makimura M, Sanefuji M, Fukamachi S, Akiyoshi H, So H, Yamamura K, Doisaki S, Kojima S, Ihara K, Hara T, Ohga S

    Brain & development   35   690 - 693   2013.8

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    Bilateral stenosis of carotid siphon in Hutchinson-Gilford progeria syndrome.

    DOI: 10.1016/j.braindev.2012.10.008

  • Feasibility of reduced-intensity conditioning followed by unrelated cord blood transplantation for primary hemophagocytic lymphohistiocytosis: a nationwide retrospective analysis in Japan Reviewed

    Akihisa Sawada, Shouichi Ohga, Eiichi Ishii, Masami Inoue, Keiko Okada, Jiro Inagaki, Hiroaki Goto, Nobuhiro Suzuki, Kazutoshi Koike, Yoshiko Atsuta, Ritsuro Suzuki, Hiromasa Yabe, Keisei Kawa, Koji Kato, Koji Yasutomo

    INTERNATIONAL JOURNAL OF HEMATOLOGY   98 ( 2 )   223 - 230   2013.8

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    DOI: 10.1007/s12185-013-1391-z

  • A Non-invasive Diagnosis of Histiocytic Necrotizing Lymphadenitis by Means of Gene Expression Profile Analysis of Peripheral Blood Mononuclear Cells Reviewed

    Masataka Ishimura, Hiroyuki Yamamoto, Yumi Mizuno, Hidetoshi Takada, Motohiro Goto, Takehiko Doi, Takayuki Hoshina, Shouichi Ohga, Koichi Ohshima, Toshiro Hara

    JOURNAL OF CLINICAL IMMUNOLOGY   33 ( 5 )   1018 - 1026   2013.7

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    DOI: 10.1007/s10875-013-9897-y

  • Protein C deficiency as the major cause of thrombophilias in childhood. Reviewed

    Ohga S, Ishiguro A, Takahashi Y, Shima M, Taki M, Kaneko M, Fukushima K, Kang D, Hara T, Japan Childhood Thrombophilia Study Group

    Pediatrics international : official journal of the Japan Pediatric Society   55 ( 3 )   267 - 271   2013.6

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    Protein C deficiency as the major cause of thrombophilias in childhood.

    DOI: 10.1111/ped.12102

  • Serum neutrophil gelatinase-associated lipocalin as a predictor of the development of bronchopulmonary dysplasia in preterm infants. Reviewed International journal

    Hirosuke Inoue, Shouichi Ohga, Takeshi Kusuda, Junko Kitajima, Tadamune Kinjo, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Toshiro Hara

    Early human development   89 ( 6 )   425 - 9   2013.6

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    DOI: 10.1016/j.earlhumdev.2012.12.011

  • Paediatric presentation and outcome of congenital protein C deficiency in Japan. Reviewed

    Ohga S, Kang D, Kinjo T, Ochiai M, Doi T, Ishimura M, Kayamori Y, Urata M, Yamamoto J, Suenobu SI, Kanegane H, Ikenoue T, Shirahata A, Hara T

    Haemophilia : the official journal of the World Federation of Hemophilia   19 ( 3 )   378 - 384   2013.5

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    Paediatric presentation and outcome of congenital protein C deficiency in Japan.

    DOI: 10.1111/hae.12097

  • Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia. Reviewed

    Takahashi Y, Muramatsu H, Sakata N, Hyakuna N, Hamamoto K, Kobayashi R, Ito E, Yagasaki H, Ohara A, Kikuchi A, Morimoto A, Yabe H, Kudo K, Watanabe K, Ohga S, Kojima S, Japan Childhood, Aplastic Anemia, Study Group

    Blood   121 ( 5 )   862 - 863   2013.1

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    Rabbit antithymocyte globulin and cyclosporine as first-line therapy for children with acquired aplastic anemia.

    DOI: 10.1182/blood-2012-11-465633

  • Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine for Fulminant Aplastic Anemia Reviewed

    Yagasaki Hiroshi, Watanabe Ken-ichiro, Kudo Kazuko, Tsuchida Masahiro, Shichino Hiroyuki, Morimoto Akira, Kobayashi Ryoji, Yabe Hiromasa, Kikuchi Akira, Ohga Shouichi, Ito Etsuro, Ohara Akira, Nakahata Tatsutoshi, Kojima Seiji

    BLOOD   120 ( 21 )   2012.11

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    Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine for Fulminant Aplastic Anemia

  • Hypothyroidism and levothyroxine-responsive liver dysfunction in a patient with ring chromosome 18 syndrome. Reviewed

    Ohkubo K, Ihara K, Ohga S, Ishimura M, Hara T

    Thyroid : official journal of the American Thyroid Association   22   1080 - 1083   2012.10

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    Hypothyroidism and levothyroxine-responsive liver dysfunction in a patient with ring chromosome 18 syndrome.

    DOI: 10.1089/thy.2011.0521

  • Treatment choice of immunotherapy or further chemotherapy for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis Reviewed

    Akira Shiraishi, Shouichi Ohga, Takehiko Doi, Masataka Ishimura, Tomohito Takimoto, Hidetoshi Takada, Toshihiro Miyamoto, Yasunobu Abe, Toshiro Hara

    PEDIATRIC BLOOD & CANCER   59 ( 2 )   265 - 270   2012.8

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    DOI: 10.1002/pbc.24039

  • Hemophagocytic lymphohistiocytosis after hematopoietic stem cell transplantation in children: A nationwide survey in Japan Reviewed

    Takeshi Asano, Kazuhiro Kogawa, Akira Morimoto, Yasushi Ishida, Nobuhiro Suzuki, Shouichi Ohga, Kazuko Kudo, Shigeru Ohta, Hiroshi Wakiguchi, Ken Tabuchi, Shunichi Kato, Eiichi Ishii

    Pediatric Blood and Cancer   59 ( 1 )   110 - 114   2012.7

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    DOI: 10.1002/pbc.23384

  • Reduced-intensity conditioning in unrelated donor cord blood transplantation for familial hemophagocytic lymphohistiocytosis Reviewed

    Masanori Nishi, Ryosei Nishimura, Nobuhiro Suzuki, Akihisa Sawada, Takayuki Okamura, Naoto Fujita, Rie Kanai, Jun Yano, Souichi Adachi, Takahiro Yasumi, Emiko Sato, Koji Yasutomo, Eiichi Ishii, Shouichi Ohga

    AMERICAN JOURNAL OF HEMATOLOGY   87 ( 6 )   637 - 639   2012.6

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    DOI: 10.1002/ajh.23190

  • Tracheal aspirate gene expression in preterm newborns and development of bronchopulmonary dysplasia. Reviewed

    Hikino S, Ohga S, Kinjo T, Kusuda T, Ochiai M, Inoue H, Honjo S, Ihara K, Ohshima K, Hara T

    Pediatrics international : official journal of the Japan Pediatric Society   54 ( 2 )   208 - 214   2012.4

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    Tracheal aspirate gene expression in preterm newborns and development of bronchopulmonary dysplasia.

    DOI: 10.1111/j.1442-200X.2011.03510.x

  • Differential Transmission and Postnatal Outcomes in Triplets with Intrauterine Cytomegalovirus Infection Reviewed

    Junko Kitajima, Hirosuke Inoue, Shouichi Ohga, Tadamune Kinjo, Masayuki Ochiai, Takahisa Yoshida, Koichi Kusuhara, Toshiro Hara

    PEDIATRIC AND DEVELOPMENTAL PATHOLOGY   15 ( 2 )   151 - 155   2012.3

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    DOI: 10.2350/11-05-1034-CR.1

  • 臀部血管腫に伴う Kasabach-Merritt 症候群を疑われた新生児プロテインC欠損症の1例

    松永 友佳, 山本 順子, 大賀 正一, 横田 千恵, 高橋 保彦, 末延 聡一, 浦田 美秩代, 栢森 裕三, 康 東天, 原 寿郎

    日本小児皮膚科学会雑誌 = Journal of pediatric dermatology   31 ( 1 )   19 - 23   2012.2

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  • Antithymocyte Globulin (ATG), Cyclosporine (CyA), and Danazol Versus ATG and CyA As Treatment for Children with Aplastic Anemia: Result of Matched-Pair Analysis Reviewed

    Kudo Kazuko, Kobayashi Ryoji, Kosaka Yoshiyuki, Tsuchida Masahiro, Mugishima Hideo, Ohara Akira, Yagasaki Hiroshi, Yabe Hiromasa, Morimoto Akira, Takahashi Yoshiyuki, Ohga Shouichi, Nakahata Tatsutoshi, Kojima Seiji

    BLOOD   118 ( 21 )   1032 - 1033   2011.11

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    Antithymocyte Globulin (ATG), Cyclosporine (CyA), and Danazol Versus ATG and CyA As Treatment for Children with Aplastic Anemia: Result of Matched-Pair Analysis

  • CD4+T cells have a critical role in the proliferation of EBV-infected T and NK cells

    Imadome K, Yajima M, Arai A, Nakagawa-Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, Fujiwara S

    PLOS Pathogen   7 ( 10 )   2011.10

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  • Novel mouse xenograft models reveal a critical role of CD4 + T cells in the proliferation of ebv-infected T and NK cells Reviewed

    Ken-Ichi Imadome, Misako Yajima, Ayako Arai, Atsuko Nakazawa, Fuyuko Kawano, Sayumi Ichikawa, Norio Shimizu, Naoki Yamamoto, Tomohiro Morio, Shouichi Ohga, Hiroyuki Nakamura, Mamoru Ito, Osamu Miura, Jun Komano, Shigeyoshi Fujiwara

    PLoS Pathogens   7 ( 10 )   2011.10

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    DOI: 10.1371/journal.ppat.1002326

  • Recurrent atrial fibrillation after high-dose methylprednisolone therapy in a girl with lupus-associated hemophagocytic syndrome Reviewed International journal

    Yamamura K, Ohga S, Nishiyama K, Doi T, Tsutsumi Y, Ikeda K, Fujishima A, Takada H, Hara T

    Lupus   20 ( 8 )   871 - 875   2011.7

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  • Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single-strand RNA Reviewed International journal

    2011.7

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  • Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood Reviewed International journal

    Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T

    J Clin Virol 51(1):31-7, 2011   2011.7

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  • Relapse of aplastic anemia in children after immunosuppressive therapy: a report from the Japan Childhood Aplastic Anemia Study Group: Reviewed International journal

    Kamio T, Ito E, Ohara A, Kosaka Y, Tsuchida M, Yagasaki H, Mugishima H, Yabe H, Morimoto A, Ohga S, Muramatsu H, Hama A, Kaneko T, Nagasawa M, Kikuta A, Osugi Y, Bessho F, Nakahata T, Tsukimoto I, Kojima S

    Haematologica   96 ( 6 )   814 - 819   2011.6

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  • Serum chemokine levels and developmental outcome in preterm infants. Reviewed

    Kinjo T, Ohga S, Ochiai M, Honjo S, Tanaka T, Takahata Y, Ihara K, Hara T

    Early human development   87 ( 6 )   439 - 443   2011.6

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    Serum chemokine levels and developmental outcome in preterm infants.

    DOI: 10.1016/j.earlhumdev.2011.03.006

  • Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood. Reviewed

    Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology   51 ( 1 )   31 - 37   2011.5

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    Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood.

    DOI: 10.1016/j.jcv.2011.01.014

  • Genetic variation of vascular endothelial growth factor pathway does not correlate with the severity of retinopathy of prematurity Reviewed International journal

    Kusuda T, Hikino S, Ohga S, Kinjo T, Ochiai M, Takahata Y, Tokunaga S, Ihara K, Hata Y, Hara T

    J Perinatol 31(4):246-50, 2011   ( 31(4): )   2011.4

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  • 新生児における鉄恒常性とヘプシジン Reviewed

    北島 順子, 金城 唯宗, 大賀 正一, 落合 正行, 井上 普介, 楠田 剛, 井原 健二, 原 寿郎

    日本産婦人科・新生児血液学会誌   20 ( 2 )   103 - 111   2011.3

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    鉄は、酸素を運搬するヘモグロビンの構成原子であるが、エネルギー産生、核酸合成などに必須の微量元素である。一方、この重金属は毒性のある活性酸素種の産生源でもあるため生体は厳密な制御機構を有している。鉄の恒常性を司るいくつかの因子は感染や炎症にも関わる分子であり、細胞内外における鉄代謝の仕組みが解明されつつある。新生児とくに低出生体重児は、鉄代謝機構が未熟なため、鉄欠乏と過剰に陥りやすく、神経障害、慢性肺疾患、および未熟児網膜症への影響が懸念されている。しかし、周産期における胎児・新生児の鉄代謝は未開拓の分野であり、輸血や鉄剤投与の方法に関して多くの議論がある。ここでは肝から産生される鉄代謝ホルモン、hepcidinを中心に新生児における鉄の恒常性維持機構について概説する。(著者抄録)

  • Serum prohepcidin concentrations at birth and one month after birth in premature infants

    Kitajima J, Ohga S, Kinjo T, Ochiai M, Takahata Y, Honjo S, Hara T

    Pediatric Blood & Cancer   56 ( (2) )   2011.2

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    DOI: 10.1002/pbc.22773. Epub 2010 Sep 9.

  • Serum Prohepcidin Concentrations at Birth and 1 Month After Birth in Premature Infants Reviewed

    Junko Kitajima, Shouichi Ohga, Tadamune Kinjo, Masayuki Ochiai, Yasushi Takahata, Satoshi Honjo, Toshiro Hara

    PEDIATRIC BLOOD & CANCER   56 ( 2 )   267 - 272   2011.2

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    DOI: 10.1002/pbc.22773

  • NEMO mutation as a cause of familial occurrence of Behçet's disease in female patients. Reviewed International journal

    2010.12

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  • NEMO mutation as a cause of familial occurrence of Behcet's disease in female patients Reviewed

    H. Takada, A. Nomura, M. Ishimura, M. Ichiyama, S. Ohga, T. Hara

    CLINICAL GENETICS   78 ( 6 )   575 - 579   2010.12

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    DOI: 10.1111/j.1399-0004.2010.01432.x

  • Nephrolithiasis as an extra-intestinal presentation of pediatric inflammatory bowel disease unclassified Reviewed International journal

    Torio M, Ishimura M, Ohga S, Doi T, Utsunomiya R, Ohkubo K, Suga N, Tatsugami K, Matsumoto T, Takada H, Hara T

    J Crohns Colitis 4(6):674-678, 2010   4 ( 6 )   674 - 678   2010.12

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  • Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan. International journal

    Kudo K, Ohga S, Morimoto A, Ishida Y, Suzuki N, Hasegawa D, Nagatoshi Y, Kato S, Ishii E.

    Bone Marrow Transplant 45(5):901-906, 2010   45 ( 5 )   2010.12

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  • Mutations in the ribosomal protein genes in Japanese patients with Diamond-Blackfan anemia. Reviewed International journal

    Konno Y, Toki T, Tandai S, Xu G, Wang R, Terui K, Ohga S, Hara T, Hama A, Kojima S, Hasegawa D, Kosaka Y, Yanagisawa R, Koike K, Kanai R, Imai T, Hongo T, Park MJ, Sugita K, Ito E.

    Haematologica 95(8):1293-9, 2010   2010.8

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  • Incomplete Kawasaki disease in a patient with chronic granulomatous disease. Reviewed International journal

    Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T

    Pediatr Int 52(3):e134-136, 2010   2010.7

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  • Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan. Reviewed International journal

    Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Tabuchi T, Suzuki N, Ishida Y, Imashuku S, Kato S, Hara T, for The HLH/LCH and SCT Committees in the Japanese Society of Pediatric Hematology:

    Pediatric Blood & Cancer 54(2):299-306, 2010   2010.5

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  • Five adult cases of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis Reviewed

    Abe Y, Shiratsuchi M, Nagasawa E, Ohtsuka R, Kiyasu J, Sada E, Idutsu K, Kotoh K, Nishimura J, Ohga S, Takayanagi R.

    Rinsho Ketsueki. 2010 Jan;51(1):74-9. Japanese.   2010.1

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  • Nationwide survey of single-system single site Langerhans cell histiocytosis in Japan.

    Morimoto A, Ishida Y, Suzuki N, Ohga S, Shioda Y, Okimoto Y, Kudo K, Ishii E

    Pediatric Blood & Cancer   54 ( 1 )   2010.1

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  • Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus. Reviewed International journal

    Ishimura M, Ohga S, Ichiyama M, Kusuhara K, Takada H, Hara T, Takahashi M, Okamoto H.

    Eur J Pediatr 169(7): 899-902, 2010   2009.12

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  • Spontaneous pneumothorax after stereotactic radiotherapy for non-small-cell lung cancer Reviewed

    Ohnishi K, Shioyama Y, Nomoto S, Sasaki T, Ohga S, Yoshitake T, Toba T, Atsumi K, Shiinoki T, Terashima H, Honda H

    Jpn J Radiol   27 ( 7 )   264 - 274   2009.8

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    Spontaneous pneumothorax after stereotactic radiotherapy for non-small-cell lung cancer

    DOI: 10.1007/s11604-009-0333-4

  • Disseminated Bacillus Calmette-Guérin lymphadenitis in a patient with gp91phox- chronic granulomatous disease 25 years after vaccination. Reviewed

    168 ( 6 )   745 - 747   2009.6

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    DOI: 10.1007/s00431-008-0824-9

  • Fulminant sepsis/meningitis due to Haemophilus influenzae in a protein C-deficient heterozygote treated with activated protein C therapy. Reviewed International journal

    Ishimura M, Saito M, Ohga S, Hoshina T, Baba H, Urata M, Kira R, Takada H, Kusuhara K, Kang D, Hara T

    Eur J Pediatr 168(6):673-677, 2009   2009.5

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  • Characteristics of hemophagocytic lymphohistiocytosis in neonates: a nationwide survey in Japan. Reviewed International journal

    Suzuki N, Morimoto A, Ohga S, Kudo K, Ishida Y, Ishii E; HLH/LCH Committee of the Japanese Society of Pediatric Hematology:

    J Pediatr 155(2):235-238, 2009   2009.5

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  • Neonatal onset hemophagocytic lymphohistiocytosis in a premature infant. Reviewed International journal

    Katsuragi S, Ohga S, Horiuchi H, Hara T, Terao K, Ikeda T.

    Pediatr Blood Cancer 53(2): 244-245, 2009   2009.5

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  • Disseminated Bacillus Calmette-Guérin lymphadenitis in a patient with gp91phox (-) chronic granulomatous disease 25 years after vaccination. Reviewed International journal

    2009.5

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  • Cardiovascular complications associated with chronic active epstein-barr virus infection. Reviewed International journal

    Muneuchi J, Ohga S, Ishimura M, Ikeda K, Yamaguchi K, Nomura A, Takada H, Abe Y, Hara T

    Pediatr Cardiol. 2009 Apr;30(3):274-81   2009.4

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  • Epstein-Barr virus load in cerebrospinal fluid of patients with chronic active Epstein-Barr virus infection. Reviewed International journal

    Ohga S, Sanefuji M, Ishimura M, Nomura A, Torisu H, Kira R, Takada H, Mizuno Y, Kazuyama Y, Hara T.

    Pediatr Infect Dis J. 2008 Nov;27(11):1027-30.   2008.11

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  • Relapse of Children with Aplastic Anemia after Immunosuppressive Therapy Reviewed

    Kamio Takuya, Ito Etsuro, Ohara Akira, Kosaka Yoshiyuki, Tsuchida Masahiro, Mugishima Hideo, Yabe Hiromasa, Morimoto Akira, Ohga Shouichi, Yagasaki Hiroshi, Bessho Furnio, Nakahata Tatsutoshi, Kojima Seiji

    BLOOD   112 ( 11 )   1063   2008.11

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    Relapse of Children with Aplastic Anemia after Immunosuppressive Therapy

  • Allogeneic hematopoietic stem cell transplantation for Epstein-Barr virus-associated T/natural killer-cell lymphoproliferative disease in Japan. Reviewed International journal

    Sato E, Ohga S, Kuroda H, Yoshiba F, Nishimura M, Nagasawa M, Inoue M, Kawa K.

    Am J Hematol. 2008 Sep;83(9):721-7   2008.9

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  • Epstein-Barr virus-associated meningoencephalomyelitis: intrathecal reactivation of the virus in an immunocompetent child. Reviewed International journal

    Sanefuji M, Ohga S, Kira R, Nomura A, Torisu H, Takada H, Kusuhara K, Hara T.

    J Child Neurol. 2008 Sep;23(9):1072-7.   2008.9

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  • Head circumference and long-term outcome in small-for-gestational age infants. Reviewed International journal

    Ochiai M, Nakayama H, Sato K, Iida K, Hikino S, Ohga S, Tsukimori K, Wake N, Masumoto K, Taguchi T, Hara T

    J Perinat Med. 2008;36(4):341-7.   2008.8

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  • Thromboembolic complications in splenectomized patients with dominantly inherited beta-thalassemia. Reviewed International journal

    Ohga S, Ideguchi H, Kato J, Ishimura M, Takada H, Harada N, Kawanaka H, Hattori Y, Kang D, Hamasaki N, Hara T.

    Acta Haematol. 2008;120(1):31-5.   2008.8

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  • Lipopolysaccharide-induced monocytic cell death for the diagnosis of mild neonatal-onset multisystem inflammatory disease Reviewed International journal

    Takada H, Ishimura M, Inada H, Ohga S, Kusuhara K, Moroi Y, Furue M, Hara T

    J Pediatr. 2008 Jun;152(6):885-7   2008.6

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  • Sjogren's syndrome-associated meningoencephalomyelitis: cerebrospinal fluid cytokine levels and therapeutic utility of tacrolimus Reviewed International journal

    Hoshina T, Yamaguchi Y, Ohga S, Kira R, Ishimura M, Takada H, Tanaka T, Hara T

    J Neurol Sci. 2008 Apr 15;267(1-2):182-6.   2008.4

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  • Insulin-like growth factor-II: a novel autocrine growth factor modulating the apoptosis and maturation of umbilical cord blood erythroid progenitors Reviewed International journal

    Nagatomo T, Muta K, Ohga S, Ochiai M, Ohshima K, Hara T

    Exp Hematol. 2008 Apr;36(4):401-11   2008.4

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  • Early-onset sarcoidosis mimicking refractory cutaneous histiocytosis Reviewed International journal

    Ohga S, Ichino K, Urabe K, Ishimura M, Takada H, Nishikomori R, Furue M, Hara T:

    Pediatr Blood Cancer. 2008 Mar;50(3):723-6.   2008.3

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  • Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia. Reviewed International journal

    Kosaka Y, Yagasaki H, Sano K, Kobayashi R, Ayukawa H, Kaneko T, Yabe H, Tsuchida M, Mugishima H, Ohara A, Morimoto A, Otsuka Y, Ohga S, Bessho F, Nakahata T, Tsukimoto I, Kojima S; Japan Childhood Aplastic Anemia Study Group.

    Blood. 2008 Feb 1;111(3):1054-9.   2008.2

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  • Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia Reviewed

    Yoshiyuki Kosaka, Hiroshi Yagasaki, Kimihiko Sano, Ryoji Kobayashi, Hiroshi Ayukawa, Takashi Kaneko, Hiromasa Yabe, Masahiro Tsuchida, Hideo Mugishima, Akira Hara, Akira Morimoto, Yoshitoshi Otsuka, Shouichi Ohga, Fumio Bessho, Tatsutoshi Nakahata, Ichiro Tsukimoto, Seiji Kojima

    BLOOD   111 ( 3 )   1054 - 1059   2008.2

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    DOI: 10.1182/blood-2007-08-099168

  • A new scoring system for computed tomography of the chest for assessing the clinical status of bronchopulmonary dysplasia Reviewed International journal

    Ochiai M, Hikino S, Yabuuchi H, Nakayama H, Sato K, Ohga S, Hara T

    J Pediatr. 2008 Jan;152(1):90-5   2008.1

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  • Malignant hepatic tumor occurring 10 yrs after a histocompatible sibling donor bone marrow transplantation for severe aplastic anemia. Reviewed International journal

    Ishimura M, Ohga S, Nagatoshi Y, Okamura J, Tajiri T, Kohashi K, Oda Y, Takada H, Hara T

    Pediatr Transplant. 2007 Dec;11(8):945-9.   2007.12

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  • Successful prolonged rituximab treatment for post-transplant lymphoproliferative disorder following living donor liver transplantation in a child. Reviewed International journal

    Hayashida M, Ogita K, Matsuura T, Takahashi Y, Nishimoto Y, Ohga S, Hara T, Soejima Y, Taketomi A, Maehara Y, Kohashi K, Tsuneyoshi M, Taguchi T:

    Pediatr Transplant. 2007 Sep;11(6):671-5.   2007.9

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  • Nationwide survey of hemophagocytic lymphohistiocytosis in Japan. Reviewed

    Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, Yamamoto K, Horiuchi H, Takada K, Ohshima K, Nakamura S, Kinukawa N, Oshimi K, Kawa K

    International journal of hematology   86 ( 1 )   58 - 65   2007.7

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    Nationwide survey of hemophagocytic lymphohistiocytosis in Japan.

    DOI: 10.1532/IJH97.07012

  • Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis. Reviewed

    Nagafuji K, Nonami A, Kumano T, Kikushige Y, Yoshimoto G, Takenaka K, Shimoda K, Ohga S, Yasukawa M, Horiuchi H, Ishii E, Harada M

    Haematologica   92 ( 7 )   978 - 981   2007.7

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    Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis.

    DOI: 10.3324/haematol.11233

  • Hematopoietic stem cell transplantation for Diamond-Blackfan anemia: a report from the Aplastic Anemia Committee of the Japanese Society of Pediatric Hematology Reviewed International journal

    Mugishima H, Ohga S, Ohara A, Kojima S, Fujisawa K, Tsukimoto I, for the Aplastic anemia Committee of the Japanese Society of Pediatric Hematology:

    Pediatric Transplantation 2007 (in press)   2007.1

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  • Nation-wide survey analysis of hemophagocytic lymphohistiocytosis (HLH) in Japan Reviewed International journal

    Ishii E, Ohga S, Imashuku S, Yasukawa M, Tsuda H, Miura I, Yamamoto K, Horiuchi H, Takada K, Ohshima K, Nakamura S, Kinukawa N, Oshimi K, Kawa K:

    Int J Hematol 2007 (in press)   2007.1

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  • A four-year-old girl with cough, haemoptysis and anaemia Reviewed

    Hideki Nakayama, Shouichi Ohga, Eiichi Ishii, Takeshi Inamitsu, Kunio Kishida

    ACTA PAEDIATRICA   95 ( 12 )   1707 - 1709   2006.12

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    DOI: 10.1080/08035250600796620

  • Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning Reviewed

    S Ohga, K Ichino, K Goto, S Hattori, A Nomura, H Takada, K Nakamura, T Hara

    PEDIATRIC TRANSPLANTATION   10 ( 4 )   497 - 500   2006.6

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    DOI: 10.1111/j.1399-3046.2006.00486.x

  • Correlation between phenotypic heterogeneity and gene mutational characteristics in familial hemophagocytic lymphohistiocytosis (FHL) Reviewed

    Ueda, I, E Ishii, A Morimoto, S Ohga, M Sako, S Imashuku

    PEDIATRIC BLOOD & CANCER   46 ( 4 )   482 - 488   2006.4

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    DOI: 10.1002/pbc.20511

  • Generalized lymphatic dysplasia in a translocation trisomy 21 infant with non-immune hydrops fetalis Reviewed International journal

    Ochiai M, Kand T, Hikino S, Kinjo T, Yamamoto J, Nakayama H, Ohga S, Hara T

    Am J Perinatol 23:63-66, 2006   2006.1

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  • Nonimmune hydrops fetalis due to generalized lymphatic dysplasia in an infant with Robertsonian trisomy 21 Reviewed

    M Ochiai, S Hikino, H Nakayama, S Ohga, T Taguchi, T Hara

    AMERICAN JOURNAL OF PERINATOLOGY   23 ( 1 )   63 - 66   2006.1

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    DOI: 10.1055/s-2005-918892

  • Successful self-infusion of activated prothrombin complex concentrate for prophylaxis in a child with a factor VIII inhibitor. Reviewed International journal

    Ohga S, Nomura A, Takada H, Suga N, Hara T:

    Am J Hematol 82:145-149, 2007   2006.1

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  • A four-year-old girl with cough, hemoptysis and anemia. Reviewed International journal

    Nakayama H, Ohga S, Ishii E, Inamitsu T, Kishida K:

    Atca Paediatr 95:1707-1709, 2006   2006.1

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  • Barium-associated appendicitis in a childhood case with Crohn's disease. Reviewed International journal

    Nagata H, Ohga S, Hattori S, Masumoto K, Taguchi T, Matsumoto T, Hara T:

    Acta Paediatr 95:889-890, 2006   2006.1

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  • Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection. Reviewed International journal

    Toubo T, Ohga S, Takada H, Suga N, Nomura A, Ohno T, Hara T:

    Acta Paediatr 95:614-618, 2006   2006.1

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  • Unrelated cord blood donor transplantation for childhood severe aplastic anemia after a modified conditioning. Reviewed International journal

    Ohga S, Ichino K, Goto K, Hattori S, Nomura A, Takada H, Nakamura K, Hara T:

    Pediatr Transplant 10:497-500, 2006   2006.1

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  • Epstein-Barr virus associated broncial leiomyoma in a boy with a cellular immunodeficiency. Reviewed International journal

    Hatano M, Takada H, Nomura A, Ohga S, Ohshima K, Saeki I, Tajiri T, Taguchi T, Suita S, Hara T:

    Pediatr Pulmonology 41:371-373, 2006   2006.1

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  • Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. Reviewed International journal

    Kobayashi R, Yabe H, Hara J, Morimoto A, Tsuchida M, Mugishima H, Ohara A, Tsukimoto I, Kato K, Kigasawa H, Tabuchi K, Nakahata T, Ohga S, Kojima S; the Japan Childhood Aplastic Anemia Study Group.

    Br J Haematol 135:693-696, 2006   2006.1

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  • Reduced gene expression of clustered ribosomal proteins in Diamond-Blackfan anemia patients without RPS19 gene mutations. Reviewed International journal

    Koga Y, Ohga S, Nomura A, Takada H, Hara T:

    J Pediatr Hematol Oncol 28:355-361, 2006   2006.1

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  • Long -term outcome in twin -to-twin transfusion syndrome. Reviewed International journal

    Hikino S, Ohga S, Kanda T, Nakashima T, Yamamoto J, Nakayama H, Nakano H, Hara T:

    Fetal Diag Ther 22:68-74, 2006   2006.1

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  • Maturational alterations of peripheral T cell subsets and cytokine gene expression in chromosome 22q11.2 deletion syndrome. Reviewed International journal

    Kanaya Y, Ohga S, Ikeda K, Furuno K, Ohno T, Takada H, Kinukawa N, Hara T:

    Clin Exp Immunol 144:85-89, 2006   2006.1

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  • Phenotypic heterogeneity of familial hemophagocytic lymphohistiocytosis (FHL) in relation to gene mutational characteristics Reviewed International journal

    Ueda I, Ishii E, Morimoto A, Ohga S, Sako M, Imashuku S

    Pediatr Blood & Cancer 46:482-488, 2006   2006.1

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  • A case of chronic recurrent uveitis associated with chronic granulomatous disease Reviewed International journal

    Matsuura T, Sonoda K, Ohga S, Ishibashi T

    Jap J Ophthalmol 50:287-289, 2006.   2006.1

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  • Prolonged severe pancytopenia as the first manifestation of systemic juvenile xanthogranuloma Reviewed International journal

    Hara T, Ohga S, Hattori S, Hatano M, Kaku N, Nomura A, Takada H, Kokuba N, Hara T

    Pediatr Blood Cancer 47:103-106, 2006   2006.1

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  • T-cell-depleted CD34+ cell transplantation from an HLA-mismatched donor in a low-birth weight infant with X-linked severe combined immunodeficiency Reviewed International journal

    Nomura A, Takada H, Ohga S, Ishii N, Inoue T, Hara T

    J Pediatr Hematol Oncol 27:80-84, 2005   27 ( 2 )   80 - 84   2005.1

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    DOI: 10.1097/01.mph.0000152859.59880.54

  • Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people Reviewed International journal

    Yamamoto K, Ishii E, Horiuchi H, Ueda I, Ohga S, Nishi M, Ogata Y, Zaitsu M, Morimoto A, Hara T, Imashuku S, Sasazuki T, Yasukawa M

    J Human Genet 50:600-603, 2005   50 ( 11 )   600 - 603   2005.1

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    DOI: 10.1007/s10038-005-0293-1

  • Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome Reviewed International journal

    Tanaka T, Takada H, Nomura A, Ohga S, Shibata R, Hara T

    Clin Exp Immunol 140:524-531, 2005   140 ( 3 )   524 - 531   2005.1

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    DOI: 10.1111/j.1365-2249.2005.02805.x

  • Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions Reviewed International journal

    Ishii E, Ueda I, Shirakawa R, Yamamoto K, Horiuchi H, Ohga S, Furuno K, Morimoto A, Imayoshi M, Ogata Y, Zaitsu M, Sako M, Koike K, Sakata A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M

    Blood 105:3442-3448, 2005   105 ( 9 )   3442 - 3448   2005.1

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    DOI: 10.1182/blood-2004-08-3296

  • A novel CIAS1mutation in a Japanese patient with chronic infantile neurological cutaneous and articular syndrome Reviewed International journal

    Takada H, Kusuhara K, Nomura A, Ohga S, Hayashi M, Furue M, Hara T

    Eur J Pediatr 164:785-786, 2005   164 ( 12 )   785 - 786   2005.1

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    DOI: 10.1007/s00431-005-1750-8

  • Bronchiolitis obliterance organizing pneumonia as an initial manifestation in systemic lupus erythematosus Reviewed International journal

    Takada H, Saito Y, Nomura A, Ohga S, Nakashima N, Aishima S, Tsuru N, Hara T

    Pediatr Pulmonol 40:257-260, 2005   40 ( 3 )   257 - 260   2005.1

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    DOI: 10.1002/ppul.20224

  • Moyamoya syndrome in a splenectomized patient with β-thalassemia intermedia Reviewed International journal

    21 ( 1 )   75 - 77   2005.1

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    DOI: 10.2310/7010.2006.00006

  • Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after double failures of hematopoietic stem cell transplantation Reviewed International journal

    Ishimura M, Ohga S, Nomura A, Toubo T, Morihana E, Saito Y, Nishio H, Ide M, Takada H, Hara T

    Am J Haematol 80:204-206, 2005   80 ( 3 )   207 - 212   2005.1

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    DOI: 10.1002/ajh.20430

  • Dominant expression of interleukin-10 and transforming growth factor-β genes in activated T-cells of chronic active Epstein-Barr virus infection. Reviewed International journal

    74 ( 3 )   449 - 458   2004.11

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    DOI: 10.1002/jmv.20197

  • 調節性T細胞としての臍帯血CD25+CD4T細胞の機能解析 Reviewed

    高畑 靖, 高田 英俊, 野村 明彦, 古野 憲司, 山本 順子, 曳野 俊治, 中山 英樹, 大賀 正一, 原 寿郎

    日本小児科学会雑誌   108 ( 2 )   330 - 330   2004.2

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  • Diamond-Blackfan anemia in Japan: Outcomes of prednisolone therapy and hematopoietic stem cell transplantation Reviewed International journal

    Ohga S, Mugishima H, Ohara A, Kojima S, Fujisawa K, Yagi K, Higashikawa M, Tsukimoto I for the Aplastic Anemia Committee of the Japanese Society of Pediatric Hematology:

    Int J Hematol 79:22-30, 2004   79 ( 1 )   22 - 30   2004.1

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    DOI: 10.1007/BF02983529

  • Increased IL-16 levels in hemophagocytic lymphohistiocytosis. Reviewed International journal

    Takada H, Ohga S, Mizuno Y, Nomura A, Hara T:

    J Pediatr Hematol/Oncol 26:567-573, 2004   26 ( 9 )   567 - 573   2004.1

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    DOI: 10.1097/01.mph.0000134465.86671.2e

  • Human cord blood CD25+CD4+ T cells: a novel immunoregulatory population with naive phenotype. Reviewed International journal

    Takahata Y, Nomura A, Takada H, Ohga S, Hikino S, Nakayama H, Sakaguchi S, Hara T:

    Exp Hematol 32:622-629, 2004   2004.1

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  • Clinicopathological states of Epstein-Barr virus-associated T/NK-cell lymphoproliferative disorders (severe chronic active EBV infection) of children and young adults. Reviewed International journal

    Suzuki K, Ohshima K, Karube K, Suzumiya J, Ohga S, Ishihara S, Tamura K, Kikuchi M:

    Int J Oncol 24:1165-74, 2004   24 ( 5 )   1165 - 1174   2004.1

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  • MUNC13-4 mutations and cytotoxic function of MUNC13-4-deficient-T lymphocytes in familial hemophagocytic lymphohistiocytosis. Reviewed International journal

    Yamamoto K, Ishii E, Sako M, Ohga S, Furuno K, Suzuki N, Ueda I, Imayoshi M, Yamamoto S, Morimoto A, Takada H, Hara T, Imashuku S, Sasazuki T, Yasukawa M:

    J Med Genet 41:763-767, 2004   2004.1

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  • Microarray analysis of human milk cells: Persistent high expression of osteopontin during the lactating period. Reviewed International journal

    Nagatomo T, Ohga S, Takada H, Nomura A, Hikino S, Imura M, Ohshima K, Hara T:

    Clin Exp Immunol 138:47-53, 2004   138 ( 1 )   47 - 53   2004.1

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    DOI: 10.1111/j.1365-2249.2004.02549.x

  • Impaired host defense against Sporothrix schenckii in mice with chronic granulomatous disease. Reviewed International journal

    Kajiwara H, Saito M, Ohga S, Uenotsuchi T, Yoshida S:

    Infect Immunity 72:5073-5079, 2004   72 ( 9 )   5073 - 5079   2004.1

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    DOI: 10.1128/IAI.72.9.5073-5079.2004

  • Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome. Reviewed International journal

    Toubo T, Suga N, Ohga S, Nomura A, Onoe Y, Takada H, Morihana E, Hara T:

    Int J Hematol 80:458-62, 2004   80 ( 5 )   458 - 462   2004.1

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    DOI: 10.1532/IJH97.04081

  • Dominant beta-thalassemia with hemoglobin Hradec Kralove: Enhanced hemolysis in the spleen Reviewed

    S Ohga, A Nomura, H Takada, J Kato, H Ideguchi, Y Hattori, M Suda, S Suita, T Hara

    INTERNATIONAL JOURNAL OF HEMATOLOGY   78 ( 4 )   329 - 334   2003.11

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  • 慢性活動性EBウイルス感染症における活性化T細胞の遺伝子発現 Reviewed

    大賀 正一, 野村 明彦, 田中 珠美, 高畑 靖, 古野 憲司, 菅 尚浩, 高田 英俊, 絹川 直子, 原 寿郎

    日本小児血液学会雑誌   17 ( 4 )   219 - 219   2003.8

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  • 調節性T細胞としての臍帯血CD25+CD4+T細胞の機能解析 Reviewed

    高畑 靖, 高田 英俊, 野村 明彦, 古野 憲司, 山本 順子, 曳野 俊治, 中山 英樹, 大賀 正一, 原 寿郎

    日本産婦人科・新生児血液学会誌   13 ( 1 )   S67 - S68   2003.5

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  • Cytokine imbalance in hyper-IgE syndrome: reduced expression of transforming growth factor-beta and interferon-gamma genes in circulating activated T cells Reviewed International journal

    Ohga S, Nomura A, Ihara K, Takahata Y, Akeda H, Shibata R, Okamura J, Kinukawa N, Hara T:

    Br J Haematol 121:324-331, 2003   121 ( 2 )   324 - 331   2003.1

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    DOI: 10.1046/j.1365-2141.2003.04267.x

  • Lymphoproliferative Disease in Childhood: Clinical and biological role of cytokines Invited Reviewed International journal

    Ohga S, Takada H, Nomura A, Hara T:

    Research Advances in Blood by GLOBAL RESEARCH NETWORK, 27-37, 2003   2003.1

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  • Quantification of circulating varicella zoster virus-DNA for the early diagnosis of visceral varicella Reviewed International journal

    Ishizaki Y, Tezuka J, Ohga S, Nomura N, Suga N, Kuromaru R, Kusuhara K, Mizuno Y, Kasuga N, Hara T:

    J Infect 47:133-138, 2003   47 ( 2 )   133 - 138   2003.1

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    DOI: 10.1016/S0163-4453(03)00004-5

  • Prognostic factors for chronic active Epstein-Barr virus infection Reviewed International journal

    Kimura H, Morishima T, Kanegane H, Ohga S, Hoshino Y, Maeda A, Imai S, Okano M, Morio T, Yokota S, Tsuchiya S, Yachie A, Imashuku S, Kawa K, Wakiguchi H, and Members of the Japanese Association for Research on Epstein-Barr Virus and related Diseases:

    J Infect Dis 187:527-533, 2003   187 ( 4 )   527 - 533   2003.1

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    DOI: 10.1086/367988

  • Increased serum levels of interferon-gamma-inducible protein 10 and monokine induced by gamma interferon in patients with hemophagocytic lymphohistiocytosis Reviewed International journal

    Takada H, Takahata Y, Nomura A, Ohga S, Mizuno Y, Hara T:

    Clin Exp Immunol 133:448-453, 2003   133 ( 3 )   448 - 453   2003.1

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    DOI: 10.1046/j.1365-2249.2003.02237.x

  • Differential chemokine, chemokine receptor and cytokine expression in Epstein-Barr virus-associated lymphoproliferative diseases Reviewed International journal

    Ohshima K, Karube K, Hamasaki M, Tutiya T, Yamaguchi T, Suefuji H, Suzuki K, Suzumiya J, Ohga S, Kikuchi M:

    Leuk Lymphoma 44:1367-1378, 2003   44 ( 8 )   1367 - 1378   2003.1

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    DOI: 10.1080/1042819031000082984

  • Dominant expression of IL-10 but not IFN-gamma in CD4- CD8- alpha/beta T cells of autoimmune lymphoproliferative syndrome Reviewed International journal

    Ohga S, Nomura A, Takahata Y, Ihara K, Takada H, Wakiguchi H, Kudo Y, Hara T:

    Br J Haematol 119:535-538, 2002   119 ( 2 )   535 - 538   2002.11

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    DOI: 10.1046/j.1365-2141.2002.03848.x

  • Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations. Reviewed

    Kogawa K, Kudoh J, Nagafuchi S, Ohga S, Katsuta H, Ishibashi H, Harada M, Hara T, Shimizu N

    Clinical immunology (Orlando, Fla.)   103 ( 3 Pt 1 )   277 - 283   2002.6

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    Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations.

    DOI: 10.1006/clim.2002.5208

  • Perforin defects of primary hemophagocytic lymphohistiocytosis in Japan Reviewed International journal

    Suga N, Takada H, Nomura A, Ohga S, Ishii E, Ihara K, Ohshima K, Hara T:

    Br J Haematol 116:346-349, 2002   116 ( 2 )   346 - 349   2002.2

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    DOI: 10.1046/j.1365-2141.2002.03266.x

  • CD4-CD8- T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection Reviewed International journal

    Tsutsumi S, Ohga S, Nomura A, Takada H, Sakai S, Ohshima K, Sumimoto K, Hara T:

    Am J Hematol 71:211-215, 2002   71 ( 3 )   211 - 215   2002.1

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    DOI: 10.1002/ajh.10207

  • Treatment responses of childhood aplastic anemia with chromosomal aberrations at diagnosis Reviewed International journal

    Ohga S, Ohara A, Hibi S, Kojima S, Bessho F, Tsuchiya S, Ohshima Y, Yoshida N, Kashii Y, Nishimura S, Kawakami K, Nishikawa K, Tsukimoto I for the Aplastic Anemia Committee of the Japanese Society of Pediatric Hematology:

    Br J Haematol 118:313-319, 2002   118 ( 1 )   313 - 319   2002.1

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    DOI: 10.1046/j.1365-2141.2002.03582.x

  • Phenotype of autoimmune polyglandular syndrome type 1 and genotype of AIRE gene in a Japanese family Reviewed International journal

    Kogawa K, Kudoh J, Nagafuchi S, Katsuta H, Ohga S, Tamiya S, Sakai Y, Harada M, Hara T, Shimizu N:

    Clin Immunol 103:277-283, 2002   2002.1

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  • Optic disk vasculitis associated with chronic active epstein-barr virus infection Reviewed International journal

    Yamamoto M, Ohga S, Ohnishi Y, Inomata H:

    Ophthalmologica 216:221-225, 2002   216 ( 3 )   221 - 225   2002.1

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    DOI: 10.1159/000059638

  • Expansion of trisomy 8 and Sweet syndrome in a prolonged course of childhood aplastic anemia Reviewed International journal

    Ohga S, Nomura A, Takada H, Terao H, Harada N, Hara T:

    J Pediatr Hematol/Oncol 24:64-68, 2002   24 ( 1 )   64 - 68   2002.1

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    DOI: 10.1097/00043426-200201000-00017

  • Epstein-Barr virus associated diseases in childhood.-Immunological aspects of Epstein-Barr virus infection Invited Reviewed International journal

    Ohga S, Nomura A, Takada H, Hara T:

    Crit Rev Oncol Hematol 44:203-215, 2002   2002.1

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  • Epstein-Barr virus (EBV) load and cytokine gene expression in activated T cells of chronic active EBV infection Reviewed International journal

    Ohga S, Nomura A, Takada H, Ihara K, Kawakami K, Yanai F, Takahata Y, Tanaka T, Kasuga N, Hara T:

    J Infect Dis 183:1-7, 2001   183 ( 1 )   1 - 7   2001.1

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    DOI: 10.1086/317653

  • Quantitative monitoring of circulating Epstein-Barr virus DNA for predicting the development of posttransplantation lymphoproliferative disease Reviewed International journal

    Ohga S, Kubo E, Nomura A, Takada H, Suga N, Ishii E, Suminoe A, Inamitsu T, Matsuzaki A, Kasuga N, Hara T:

    Int J Haematol 73:323-326, 2001   73 ( 3 )   323 - 326   2001.1

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    DOI: 10.1007/BF02981956

  • Progressive vascular calcification in autoimmune polyglandular syndrome type I Reviewed International journal

    Ohga S, Matsumoto N, Takada H, Nomura A, Matsuda T, Hara T:

    Pediatric Radiology 31:213-214, 2001   31 ( 3 )   213 - 214   2001.1

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    DOI: 10.1007/s002470000403

  • Moyamoya syndrome with spherocytosis: Effect of splenectomy on strokes Reviewed International journal

    Tokunaga Y, Ohga S, Suita S, Matsushima T, Hara T:

    Pediatr Neurology 25:75-77, 2001   25 ( 1 )   75 - 77   2001.1

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    DOI: 10.1016/S0887-8994(01)00283-1

  • Inflammatory bowel disease-like colitis in glycogen storage disease type 1b Reviewed International journal

    Yamaguchi T, Ihara K, Matsumoto T, Tsutsumi Y, Nomura A, Ohga S, Hara T:

    Inflamm Bowel Dis 7:128-132, 2001   7 ( 2 )   128 - 132   2001.1

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    DOI: 10.1097/00054725-200105000-00008

  • IL-18 in hemophagocytic lymphohistiocytosis Invited Reviewed International journal

    Takada H, Nomura A, Ohga S, Hara T:

    Leuk & Lymphoma 42:21-28, 2001   2001.1

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  • H2O2 nonproduction as a phenotype in Streptococcus pyogenes strains: its relation to stationary-phase survival and resistance to intracellular killing by granulocytes of chronic granulomatous disease patients Reviewed International journal

    Saito M, Ohga S, Endoh M, Nakayama H, Hara T, Yoshida S:

    Microbiology 147:2469-2477, 2001   2001.1

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  • Functional analyses of cord blood natural killer cells and T cells. a distinctive interleukin-18 response Reviewed International journal

    Nomura A, Takada H, Jin C, Tanaka T, Ohga S, Hara T:

    Exp Hematol 29:1169-1176, 2001   29 ( 10 )   1169 - 1176   2001.1

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    DOI: 10.1016/S0301-472X(01)00689-0

  • 多発性内分泌および外分泌腺障害,汎血球減少を伴い,眼瞼下垂,筋力低下を示す5歳女児例 Reviewed

    久保 鋭治, 酒見 好弘, 吉良 龍太郎, 黒丸 龍一, 大賀 正一, 原島 知恵

    脳と発達   32 ( 4 )   371 - 371   2000.7

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  • T-cell lymphoproliferative disorder involving the central nervous system in two cases Reviewed

    S Inoha, T Inamura, S Ohga, T Hara, M Fukui

    NEUROLOGICAL SURGERY   28 ( 5 )   435 - 439   2000.5

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  • Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia International journal

    Ohga S, Kanaya Y, Maki H, Takada H, Ohshima K, Kanda M, Nomura A, Suminoe A, Matsuzaki A, Hara T:

    Bone Marrow Transplant 25:209-212, 2000   25 ( 2 )   209 - 212   2000.1

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    DOI: 10.1038/sj.bmt.1702138

  • Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation Reviewed International journal

    Honda K, Takada H, Nagatoshi Y, Akazawa K, Ohga S, Ishii E, Okamura J, Hara T:

    Bone Marrow Transplant 25:647-652, 2000   25 ( 6 )   647 - 652   2000.1

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    DOI: 10.1038/sj.bmt.1702198

  • Pneumocystis carinii pneumonia in Diamond-Blackfan anemia: the necessity of chemoprophylaxis for young infant Reviewed International journal

    Nomura A, Ohga S, Asaka Y, Takada H, Nakao F, Kusuhara K, Hara T:

    Int J Pediatr Hematol/Oncol 7:7-11, 2000   7 ( 1 )   7 - 11   2000.1

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  • Neurotropin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis International journal

    Mizuno Y, Takada H, Uragami K, Ihara K, Kira R, Suminoe A, Ohga S, Aoki T, Hara T:

    J Child Neurol 15:19-21, 2000   15 ( 1 )   19 - 21   2000.1

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    DOI: 10.1177/088307380001500104

  • Neuron specific enolase in hemophagocytic lymphohistiocytosis: a potential indicator for macrophage activation? Reviewed International journal

    Honda K, Ohga S, Takada H, Ohshima K, Kinukawa N, Nomura A, Hara T:

    Int J Hematol 72:55-60, 2000   72 ( 1 )   55 - 60   2000.1

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  • MR choroid plexus sign of iron overload in secondary hemochromatosis Reviewed International journal

    Kira R, Ohga S, Takada H, Gondo K, Mihara F, Hara T:

    Neurology 55:1340, 2000   2000.1

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  • Inflammatory Bowel Disease in Anhidrotic Ectodermal Dysplasia: the lethal complication in two cases Reviewed International journal

    Ohga S, Ryu A, Nagatomo T, Takada H, Ihara K, Kawamoto K, Kai T, Hara T:

    Am J Gastroenterol 95:3651-3652, 2000   2000.1

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  • CD95 (Fas) ligand expression of Epstein-Barr virus (EBV)-infected lymphocytes: a possible mechanism of immune evasion in chronic active EBV infection Reviewed International journal

    Ohshima K, Suzumiya J, Sugihara M, Nagafuchi S, Ohga S, Kikuchi M:

    Pathol International 49:9-13, 1999   49 ( 1 )   9 - 13   1999.1

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    DOI: 10.1046/j.1440-1827.1999.00816.x

  • WASP is involved in proliferation and differentiation of human haematopoietic progenitors in vitro Reviewed International journal

    Kajiwara M, Nonoyama S, Eguchi M, Morio T, Imai K, Okawa H, Kaneko M, Sako M, Ohga S, Maeda M, Hibi S, Hashimito H, Shibuya A, Ochs HD, Nakahata T, Yata J:

    Br J Haematol 107:254-262, 1999   107 ( 2 )   254 - 262   1999.1

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    DOI: 10.1046/j.1365-2141.1999.01694.x

  • Trisomy 10 in a child with acute nonlymphocytic leukemia followed by relapse with a different clone Reviewed International journal

    Sakai Y, Nakayama H, Matsuzaki A, Nagatoshi Y, Suminoe A, Honda K, Inamitsu T, Ohga S, Hara T:

    Cancer Genet Cytogenet 115:47-51, 1999   115 ( 1 )   47 - 51   1999.1

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    DOI: 10.1016/S0165-4608(99)00087-4

  • Streptococcus intermedius-brain abscess in chronic granulomatous disease Reviewed International journal

    Nagatomo T, Ohga S, Saito M, Takada H, Sasaki Y, Okada K, Inamura T, Hara T:

    Eur J Pediatr 158:872-873, 1999   158 ( 10 )   872 - 873   1999.1

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    DOI: 10.1007/s004310051231

  • Restricted diversification of T-cells in chronic active Epstein-Barr virus infection: Potential inclination to T-lymphoproliferative disease Reviewed International journal

    Ohga S, Kimura N, Takada H, Nagano M, Ohshima K, Nomura A, Muraoka M, Take H, Yamamori S, Hara T:

    Am J Hematol 61:26-33, 1999   61 ( 1 )   26 - 33   1999.1

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    DOI: 10.1002/(SICI)1096-8652(199905)61:1<26::AID-AJH6>3.0.CO;2-R

  • Oversecretion of interleukin-18 in hemophagocytic lymphohistiocytosis: a novel marker of disease activity Reviewed International journal

    Takada H, Ohga S, Mizuno Y, Suminoe A, Matsuzaki A, Ihara K, Kinukawa N, Ohshima K, Kohno K, Kurimoto M, Hara T:

    Br J Hematol 106:182-189, 1999   106 ( 1 )   182 - 189   1999.1

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    DOI: 10.1046/j.1365-2141.1999.01504.x

  • Cerebrospinal fluid cytokine levels and dexamethasone therapy in bacterial meningitis Reviewed International journal

    Ohga S, Okada K, Ueda K, Takada H, Ohta M, Aoki T, Kinukawa N, Miyazaki S, Hara T:

    J Infect 39;55-60, 1999   39 ( 1 )   55 - 60   1999.1

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    DOI: 10.1016/S0163-4453(99)90103-2

  • Cerebrospinal fluid cytokine concentrations in a patient with lupus meningoencephalitis: differences from cytokine profiles in central nervous system infections Reviewed International journal

    Ohga S, Gondo K, Nomura A, Onoe Y, Matsuzaki A, Hara T:

    Br J Rheumatol 37:111-112, 1998   37 ( 1 )   111 - 112   1999.1

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  • Central nervous system T-lymphoproliferative disorder in chronic active Epstein-Barr virus infection Reviewed International journal

    Ohga S, Takada H, Honda K, Inamura T, Gondo K, Ohshima K, Yamamoto M, Hara T:

    J Pediatr Hematol/Oncol 21:42-46, 1999   21 ( 1 )   42 - 46   1999.1

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    DOI: 10.1097/00043426-199901000-00011

  • Analysis of neurofibromatosis type 1 gene mutation in juvenile chronic myelogenous leukemia Reviewed International journal

    Watanabe I, Horiuchi T, Hatta N, Matsumoto M, Koike K, Kojima S, Ohga S, Fujita S:

    Acta Hematologica 100:22-25, 1998   100 ( 1 )   22 - 25   1998.1

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    DOI: 10.1159/000040858

  • Interferon-a therapy for chronic myelogenous leukemia during pregnancy Reviewed International journal

    Kuroiwa M, Gondo H, Ashida K, Kamimura T, Miyamoto T, Niho Y, Tsukimori K, Nakano H, Ohga S:

    Am J Hematol 59:101-102, 1998   59 ( 1 )   101 - 102   1998.1

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    DOI: 10.1002/(SICI)1096-8652(199809)59:1<101::AID-AJH23>3.0.CO;2-D

  • Interferon-a therapy for chronic active Epstein-Barr virus infection : Potential effect on the development of T-lymphoproliferative disease Reviewed International journal

    Sakai Y, Ohga S, Tonegawa Y, Takada H, Nakao F, Nakayama H, Aoki T, Yamamori S, Hara T:

    J Pediatr Hematol/Oncol 20:342-346, 1998   20 ( 4 )   342 - 346   1998.1

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    DOI: 10.1097/00043426-199807000-00013

  • Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome Reviewed International journal

    Ohshima K, Suzumiya J, Sugihara M, Nagafuchi S, Ohga S, Kikuchi M:

    Pathol International 48:934-943, 1998   48 ( 12 )   934 - 943   1998.1

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    DOI: 10.1111/j.1440-1827.1998.tb03864.x

  • Clinical and epidemiological studies of familial erythrophagocytic lymphohistiocytosis in Japan Reviewed International journal

    Ishii E, Ohga S, Tanimura M, Mizutani S, Sako M, Imashuku S, Miyazaki S:

    Med Pediatr Oncol 30:276-283, 1998   30 ( 5 )   276 - 283   1998.1

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    DOI: 10.1002/(SICI)1096-911X(199805)30:5<276::AID-MPO3>3.0.CO;2-C

  • Prolonged resolution of hemophagocytic lymphohistiocytosis following myeloablative chemotherapy and subsequent autologous peripheral blood stem cell transplantation Reviewed

    S Ohga, A Nomura, T Kai, A Matsuzaki, S Inaba, M Suda, K Ueda

    BONE MARROW TRANSPLANTATION   19 ( 6 )   633 - 635   1997.3

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  • Familial erythrophagocytic lymphohistiocytosis: surface marker analysis using monoclonal antibodies Reviewed International journal

    Ishii E, Hara T, Ohga S, Ueda K, Suda M, Nakamura J, Yanagi T, Tsuji Y:

    Eur J Haematol 38:63-66, 1987   38 ( 1 )   63 - 66   1997.1

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  • What are the essential symptoms in the Hoyeraal Hreidarsson syndrome ? Reviewed International journal

    Ohga S, Kai T, Honda K, Nomura A, Inamitsu T, Ueda K:

    Eur J Pediatr 156:80-81, 1997   156 ( 1 )   80 - 81   1997.1

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  • Prolonged resolution of hemophagocytic lymphohistiocytosis after high dose chemotherapy followed by autologous peripheral blood stem cell transplantation Reviewed International journal

    Ohga S, Matsuzaki A, Kai T, Nomura A, Inaba S, Suda M, Ueda K:

    Bone Marrow Transplant 19:633-635, 1997   19 ( 6 )   633 - 635   1997.1

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    DOI: 10.1038/sj.bmt.1700702

  • Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease: a case report Reviewed International journal

    Ohga S, Ikeuchi K, Kadoya K, Okada K, Miyazaki C, Suita S, Ueda K:

    J Infect 34:147-150, 1997   34 ( 2 )   147 - 150   1997.1

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    DOI: 10.1016/S0163-4453(97)92509-3

  • Integrated Epstein-Barr virus (EBV) and chromosomal abnormality in chronic active EBV infection Reviewed International journal

    Ohshima K, Suzumiya J, Ohga S, Ohgami A, Kikuchi M:

    Int J Cancer 71:943-947, 1997   1997.1

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  • Idiopathic pulmonary hemosiderosis: current diagnosis and management Invited Reviewed International journal

    Ohga S, Miyazaki S:

    Int J Pediatr Hematol/Oncol 4:161-170, 1997   1997.1

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  • Hypogammaglobulinemia in a patient with ring chromosome 21 Reviewed International journal

    Ohga S, Nakao F, Narazaki O, Fusazaki N, Aoki T, Kamesaki K, Hara T:

    Arch Dis Childh 77:252-254, 1997   77 ( 3 )   252 - 254   1997.1

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  • Chronic myelomonocytic leukemia with t(8;9)(p11;q34) in childhood: an example of the 8p11 myeloproliferative disorder ? Reviewed International journal

    Nakayama H, Inamitsu T, Ohga S, Kai T, Suda M, Matsuzaki A, Ueda K:

    Br J Haematol 92:692-695, 1996   92 ( 3 )   692 - 695   1996.1

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    DOI: 10.1046/j.1365-2141.1996.00386.x

  • Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia Reviewed International journal

    Kanno H, Fujii H, Hirono A, Ishida S, Ohga S, Fukumoto K, Matsuzawa K, Ogawa S, Miwa S:

    Blood 88:2321-2325, 1996   88 ( 6 )   2321 - 2325   1996.1

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  • Granulocyte transfusion: stimulation of low dose granulocyte-colony stimulating factor in donors for leukapheresis Reviewed International journal

    Nomura A, Ohga S, Matsuzaki A, Kai T, Suda M, Inaba S, Ueda K:

    Acta Pediatr Jpn 38:317-321, 1996   38 ( 4 )   317 - 321   1996.1

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  • An abnormal fibrinogen Fukuoka II (Bβ15Gly→Cys) characterized by defective fibrin lateral association and mixed disulfide formation Reviewed International journal

    270 ( 49 )   29392 - 29399   1995.1

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  • Treatment of young relapsed Hodgkin's disease patients with high-dose chemotherapy followed by peripheral blood stem cell transplantation Reviewed International journal

    Matsuzaki A, Okamura J, Nagatoshi Y, Kai T, Ohga S, Gondo H, Inaba S, Ueda K:

    Leuk Lymphoma 18:503-509, 1995   18 ( 5-6 )   505 - 509   1995.1

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    DOI: 10.3109/10428199509059652

  • Recurrent pneumococcal meningitis in a patient with transient IgG subclass deficiency Reviewed International journal

    Ohga S, Okada K, Asahi T, Ueda K, Sakiyama Y, Matsumoto S:

    Acta Paediatr Jpn 37:196-200, 1995   1995.1

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    Language:English   Publishing type:Research paper (scientific journal)  

  • Interferon-gamma therapy for infection control in chronic granulomatous disease Reviewed International journal

    Ohga S, Okamura J, Nakayama H, Nagatoshi Y, Ueda K:

    Acta Paediatr Jpn 37:315-320, 1995   1995.1

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  • Idiopathic pulmonary hemosiderosis in Japan: 39 possible cases from a survey questionnaire Reviewed International journal

    Ohga S, Takahashi K, Miyazaki S, Kato H, Ueda K:

    Eur J Pediatr 154:994-998, 1995   154 ( 12 )   994 - 995   1995.1

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    DOI: 10.1007/BF01958645

  • Histiocytic hemophagocytosis in Kawasaki disease: changes in the hypercytokinemic state Reviewed International journal

    Ohga S, Ooshima A, Fukushige J, Ueda K:

    Eur J Pediatr 154:539-541, 1995   154 ( 7 )   539 - 541   1995.1

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    DOI: 10.1007/BF02074830

  • Herpes zoster in children with bone marrow transplantation: report from a single institution Reviewed International journal

    Nakayama H, Okamura J, Ohga S, Miyazaki C, Matsuzaki A, Ikuno Y, Ueda K, Tasaka H:

    Acta Paediatr Jpn 37:302-307, 1995   1995.1

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  • Hematologic recovery after marrow-ablative chemotherapy and peripheral blood stem cell transplantation in children Reviewed International journal

    Matsuzaki A, Kai T, Ohga S, Nomura A, Inaba S, Harada M, Ishii E, Ueda K:

    Pediatr Hematol/Oncol 12:201-204, 1995   12 ( 2 )   201 - 204   1995.1

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    DOI: 10.3109/08880019509029556

  • Haptoglobin therapy for acute favism: a Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara Reviewed International journal

    Ohga S, Higashi E, Nomura A, Matsuzaki A, Hirono A, Miwa S, Fujii H, Ueda K:

    Br J Haematol 89:421-423, 1995   89 ( 2 )   421 - 423   1995.1

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    DOI: 10.1111/j.1365-2141.1995.tb03322.x

  • Granulocyte-colony stimulating factor levels in cord blood and neonatal peripheral blood Reviewed International journal

    Nakayama H, Kukita J, Ohga S, Ueda K:

    Acta Paediatr Jpn 37:1-3, 1995   1995.1

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  • Acute promyelocytic leukemia in a patient treated with etoposide for Langerhans cell histiocytosis Reviewed International journal

    Matsuzaki A, Inamitsu T, Watanabe T, Ohga S, Ishii E, Nagatoshi Y, Tasaka H, Suda M, Ueda K:

    Br J Haematol 86:887-889, 1994   86 ( 4 )   887 - 889   1994.1

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    DOI: 10.1111/j.1365-2141.1994.tb04851.x

  • Severe aplastic anemia in a patient with primary immunodeficiency Reviewed International journal

    Ohga S, Nagashima T, Nishizaki M, Hirabaru C, Inoue T, Ise K, Hara T, Ueda K:

    Acta Paediatr Jpn 36:212-216, 1994   1994.1

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  • Serum erythropoietin levels in term and preterm infants during the first year of life Reviewed International journal

    Yamashita H, Kukita J, Ohga S, Nakayama H, Akazawa K, Ueda K:

    Am J Pediatr Hematol/Oncol 16:213-218, 1994   16 ( 3 )   213 - 218   1994.1

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  • Molecular basis ofβ-thelassemia in Japan: heterogeneity and origins of mutation Reviewed International journal

    1994.1

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  • Liposteroid against refractory pulmonary hemorrhage in idiopathic pulmonary hemosiderosis Reviewed International journal

    Ohga S, Nomura A, Suga N, Hikino S, Kira R, Matsuzaki A, Masuda K, Ueda K:

    Eur J Pediatr 153:687-690, 1994   153 ( 9 )   687 - 690   1994.1

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    DOI: 10.1007/BF02190693

  • Induction of CD33-positive blasts by granulocyte colony-stimulating factor in a child with common acute lymphoblastic leukemia Reviewed International journal

    Matsuzaki A, Ohga S, Ueda K, Okamura S:

    Int J Pediatr Hematol/Oncol 1:339-341, 1994   1994.1

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  • Homologous dinucleotide (GT or TG) deletion in Japanese patients with chronic granulomatous disease with p47-phox deficiency Reviewed International journal

    Iwata M, Nunoi H, Yamazaki H, Nakano T, Niwa H, Tsuruta S, Ohga S, Ohmi S, Kanegasaki S, Matsuda I:

    Bioch Bioph Res Commun 199:1372-1377, 1994   199 ( 3 )   1372 - 1377   1994.1

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    DOI: 10.1006/bbrc.1994.1382

  • Clonal dissemination of Epstein-Barr (EB) virus in a patient with fatal chronic active EB virus infection Reviewed International journal

    Ohga S, Matsuzaki A, Tokunaga K, Yamamori T, Suda M, Fujisawa T, Inomata H, Ishii E, Ueda K:

    Int J Pediatr Hematol/Oncol 1:305-310, 1994   1994.1

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  • Cerebrospinal fluid concentrations of interleukin-1β, tumor necrosis factor-α, and interferon-gamma in bacterial meningitis Reviewed International journal

    70 ( 2 )   123 - 125   1994.1

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  • Association between serum interleukin-6 levels and fever in children with group A beta-hemolytic streptococcal infection Reviewed International journal

    Ohga S, Nishizaki M, Nagashima T, Ueda K:

    J Thermal Biol 19:91-96, 1994   1994.1

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  • ULTRASTRUCTURAL-LOCALIZATION OF MYELOPEROXIDASE ACTIVITY IN ACUTE MONOBLASTIC LEUKEMIA Reviewed

    GUILAN, X, Y KISHIMOTO, M DATE, T KATSURADA, Y YAMAMOTO, H TANIGUCHI, K HAMAMOTO, T NAGANO, S OHGA, H KITAJIMA, M FUJIMOTO, T KIMURA, H FUJITAKE

    INTERNATIONAL JOURNAL OF HEMATOLOGY   59 ( 1 )   17 - 23   1993.12

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  • Disseminated intravascular coagulation in a patient with hemophilia B during Factor IX replacement therapy Reviewed International journal

    Ohga S, Saito M, Matsuzaki A, Kai T, Ueda K:

    Br J Hematol 84:343-345, 1993   84 ( 2 )   343 - 345   1993.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/j.1365-2141.1993.tb03078.x

  • The use of recombinant granulocyte-colony-stimulating factor for granulocyte harvest Reviewed International journal

    Inaba S, Takamatsu Y, Yamamoto A, Shimoda K, Fukuda T, Ohga S, Hamaguchi K, Ueda K:

    Transfusion 32:690-691, 1993   32 ( 7 )   690 - 691   1993.1

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    DOI: 10.1046/j.1537-2995.1992.32792391049.x

  • Serum interleukin-6 and fever at diagnosis in children with acute leukemia Reviewed International journal

    Minamishima I, Ohga S, Ishii E, Matsuzaki A, Kai T, Akazawa K, Ueda K:

    Am J Pediatr Hematol/Oncol 15:239-244, 1993   15 ( 2 )   239 - 244   1993.1

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  • Peripheral expansion of gd T cell receptor-positive cells in a patient with Crohn's disease Reviewed International journal

    Hara T, Matsumoto T, Mizuno Y, Nishizaki M, Ueda K, Motooka M, Kimura N, Oshimi K, Ohga S, Yoshikai Y:

    Acta Paediatr Jpn 35:45-48, 1993   1993.1

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  • Inflammatory cytokines in virus-associated hemophagocytic syndrome: interferon-gamma as a sensitive indicator of disease activity Reviewed International journal

    Ohga S, Matsuzaki A, Nishizaki M, Nagashima T, Kai T, Suda M, Ueda K:

    Am J Pediatr Hematol/Oncol 15:291-298, 1993   15 ( 3 )   291 - 298   1993.1

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  • Granulocyte colony-stimulating factor and platelet aggregation Reviewed International journal

    Shimoda K, Okamura S, Takamatsu Y, Inaba S, Okamura T, Ohga S, Ueda K, Niho Y:

    Lancet 341:633, 1993   341 ( 8845 )   633 - 633   1993.1

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    DOI: 10.1016/0140-6736(93)90394-V

  • A protective role of gd T cells in primary infection with Listeria monocytogenes in mice Reviewed International journal

    Hiromatsu K, Yoshikai Y, Matsuzaki G, Ohga S, Muramori K, Matsumoto K, Bluestone JA, Nomoto K:

    J Exp Med 175:49-56, 1992   175 ( 1 )   49 - 56   1992.1

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    DOI: 10.1084/jem.175.1.49

  • The measles outbreak in Chikuhou-district, Fukuoka Japan 1990: correlation between herd immunity level and outbreak size Reviewed International journal

    Ohga S, Okada K, Miyazaki C, Akazawa K, Ueda K:

    Acta Paediatr Jpn 34:447-453, 1992   1992.1

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  • The inflammatory cytokines in measles: correlation between serum interferon-g levels and lymphocyte subpopulation Reviewed International journal

    Ohga S, Miyazaki C, Okada K, Akazawa K, Ueda K:

    Eur J Pediatr 151:492-496, 1992   151 ( 7 )   492 - 496   1992.1

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    Language:English   Publishing type:Research paper (scientific journal)  

    DOI: 10.1007/BF01957751

  • Outbreaks of group A beta-hemolytic streptococcal pharyngitis in children: correlation of serotype T4 with scarlet fever Reviewed International journal

    Ohga S, Okada K, Mitsui K, Aoki T, Ueda K:

    Scand J Infect Dis 24:599-605, 1992   24 ( 5 )   599 - 605   1992.1

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    DOI: 10.3109/00365549209054645

  • MICROPARTICLE GENERATION DURING INVITRO PLATELET ACTIVATION BY ANTI-CD9 MURINE MONOCLONAL-ANTIBODIES Reviewed

    S NOMURA, H NAGATA, M SUZUKI, K KONDO, S OHGA, T KAWAKATSU, H KIDO, T FUKUROI, K YAMAGUCHI, K IWATA, M YANABU, T SOGA, T KOKAWA, K YASUNAGA

    THROMBOSIS RESEARCH   62 ( 5 )   429 - 439   1991.6

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  • Aseptic meningitis in children: correlation between fever and interferon-gamma level Reviewed International journal

    Minamishima I, Ohga S, Ishii E, Miyazaki C, Hamada K, Akazawa K, Ueda K:

    Eur J Pediatr 150:722-725, 1991   150 ( 10 )   722 - 725   1991.1

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    DOI: 10.1007/BF01958764

  • Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia Reviewed International journal

    Ishii E, Ohga S, Murao I, Kobayashi M, Kimura K, Eguchi H, Akazawa K, Ueda K:

    Leuk Res 15:143-147, 1991   15 ( 2-3 )   143 - 147   1991.1

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    DOI: 10.1016/0145-2126(91)90095-B

  • Serum interleukin-1 and tumor necrosis factor activities in febrile children with acute leukemia Reviewed International journal

    Ishii E, Ohga S, Ueda K, Akazawa K:

    Int J Hematol 54:79-84, 1991   54 ( 1 )   79 - 84   1991.1

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  • Prognosis of virus-associated hemophagocytic syndrome and malignant histiocytosis in children: correlation with serum interleukin-1 and tumor necrosis factor activity Reviewed International journal

    Ishii E, Ohga S, Aoki T, Yamada S, Sako M, Tasaka H, Kuwano A, Sasaki M, Ueda K:

    Acta Haematol 85:93-99, 1991   1991.1

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  • Kinetics of fever and its related cytokines in mice after intraperitoneal infection with Listeria monocytogenes Reviewed International journal

    Ohga S, Ueda K, Yoshikai Y, Takeda K, Hiromatsu K, Nomoto K:

    J Thermal Biol 16:103-107, 1991   16 ( 2 )   103 - 107   1991.1

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    DOI: 10.1016/0306-4565(91)90006-N

  • Augmentation of host defense against Listeria monocytogenes infection by oral administration with polysaccharide RBS (RON) Reviewed International journal

    Takeda Y, Yoshikai Y, Ohga S, Nomoto K:

    Int J Immunopharmacol 12:373-383, 1990   12 ( 4 )   373 - &   1990.1

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  • Tumor necrosis factor and fever at initial diagnosis in children with solid tumors Reviewed International journal

    Ishii E, Ohga S, Ueda K:

    Pediatr Hematol Oncol 7:253-257, 1990   7 ( 3 )   253 - 257   1990.1

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    DOI: 10.3109/08880019009033400

  • Sequential appearance of T cell receptor g/d and a/b-bearing T cells in the peritoneal cavity during an intraperitoneal infection with Listeria monocytogenes Reviewed International journal

    Ohga S, Yoshikai Y, Takeda Y, Hiromatsu K, Nomoto K:

    Eur J Immunol 20:533-538, 1990   1990.1

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  • Human gamma/delta T cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red cell aplasia Reviewed International journal

    Hara T, Mizuno Y, Nagata M, Okabe Y, Taniguchi S, Harada M, Niho Y, Oshimi K, Ohga S, Yoshikai Y, Nomoto K, Yumura K, Kawa-Ha K, Ueda K:

    Blood 75:941-950, 1990   75 ( 4 )   941 - 950   1990.1

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  • Effects of stimulated or immunologically activated macrophages on the induction of immune responses to Listeria monocytogenes Reviewed International journal

    Yoshikai Y, Ohga S, Takeda Y, Nomoto K:

    Immunobiol 180:124-137, 1990   180 ( 2-3 )   124 - 137   1990.1

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  • Different expression of T-cell receptor b-chain variable region genes in lymph nodes of lpr mice with different alleles of major histocompatibility complex Reviewed International journal

    Ohga S, Yoshikai Y, Kishihara K, Matsuzaki G, Ogimoto M, Nomoto K:

    Immunol 70:216-222, 1990   70 ( 2 )   216 - 222   1990.1

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  • Deletion of self-reactive T cells in the donor-derived-T cells but not in the host-derived T cells in allogeneic radiation chimeras Reviewed International journal

    Ogimoto M, Yoshikai Y, Matsuzaki G, Ohga S, Nomoto K:

    Thymus 17:11-22, 1991   17 ( 1 )   11 - 22   1990.1

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  • Clonal deletion of self-Mls-reactive thymocytes at the early stage in H-2 compatible but Mls-disparate radiation chimeras Reviewed International journal

    Ogimoto M, Yoshikai Y, Matsuzaki G, Ohga S, Nomoto K:

    Immunol 69:482-486, 1990   69 ( 3 )   482 - 486   1990.1

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  • Abnormal rearrangements of T-cell receptor genes occur in long-term cultured bone marrow cells of lpr/lpr mice Reviewed International journal

    Ohga S, Yoshikai Y, Kishihara K, Matsuzaki G, Nomoto K:

    Immunol 67:543-546, 1989   67 ( 4 )   543 - 546   1989.1

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  • Rearrangements of T cell antigen receptor g and d chain genes are detected in the long-term cultured bone marrow cells of athymic nude mice but not in those of euthymic mice Reviewed International journal

    Yoshikai Y, Takeda Y, Ohga S, Kishihara K, Matsuzaki G, Nomoto K:

    Immunol 66:512-516, 1989   66 ( 4 )   512 - 516   1989.1

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  • Expression and sequences of T cell receptor b-chain variable genes in the enlarged lymph nodes of C57BL/6-lpr/lpr mice Reviewed International journal

    Ohga S, Yoshikai Y, Kishihara K, Matsuzaki G, Asano T, Nomoto K:

    Clin Exp Immunol 77:130-136, 1989   77 ( 1 )   130 - 136   1989.1

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  • Functional T cell receptor delta chain gene messages in athymic nude mice Reviewed International journal

    Yoshikai Y, Matsuzaki G, Takeda Y, Ohga S, Kishihara K, Yuuki H, Nomoto K:

    Eur J Immunol 18:1039-1043, 1988   18 ( 7 )   1039 - 1043   1988.1

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    DOI: 10.1002/eji.1830180711

  • Neonatal hemophilia B with intracranial hemorrhage: case report Reviewed International journal

    Ohga S, Kajiwara M, Toubo Y, Takeuchi T, Ohtsuka M, Sano M, Ishii E, Ueda K:

    Am J Pediatr Hematol/Oncolol 10:244-248, 1988   10 ( 3 )   244 - 248   1988.1

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  • Inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia: a case report of 9-month-old infant Reviewed International journal

    Ohga S, Ishii E, Fujioka K, Ueda K:

    Ohga S, Ishii E, Fujioka K, Ueda K: Acta Hematol Jpn 50:114-118, 1987   50 ( 1 )   114 - 118   1987.1

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Books

  • 今日の診断指針 第8版

    大賀 正一

    医学書院  2020.3 

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    Language:Japanese  

  • Hematopoietic Stem Cell Transplantation in Children with Refractory Langerhans Cell Histiocytosis

    Kazuko Kudo, Miho Maeda, Nobuhiro Suzuki, Hirokazu Kanegane, Shouichi Ohga, Eiichi Ishii, Yoko Shioda, Toshihiko Imamura, Shinsaku Imashuku, Yukiko Tsunematsu, Mikiya Endo, Akira Shimada, Yuuki Koga, Yoshiko Hashii, Jiro Inagaki, Masami Inoue, Ken Tabuchi, Akira Morimoto

    BLOOD  2018.11 

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    Responsible for pages:Vol.132   Language:English  

    DOI: 10.1182/blood-2018-99-110711

  • A Novel Case of Luscan-Lumish Syndrome with SETD2-Related Overgrowth, Gorham-Stout Phenomenon and Aggressive Angiosarcoma

    Tamaki Ueda, Yuhki Koga, Kanako Ishii, Motoshi Sonoda, Kentaro Nakashima, Mitsuharu Fukazawa, Kenichi Kohashi, Yoshinao Oda, Michio Ozeki, Yoko Aoki, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER  2018.11 

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    Responsible for pages:Vol.65, p.S75   Language:English  

  • Thrombotic disorders

    Shouichi Ohga, Masataka Ishimura

    Springer Singapore  2017.6 

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    Responsible for pages:205-221   Language:English  

    DOI: 10.1007/978-981-10-3886-0_10

  • アクチュアル 脳・神経疾患の臨床. 神経免疫疾患. 小児の神経免疫疾患の治療はどうすればよいか.

    梶本まどか, 松重武志, 大賀 正一( Role: Joint author)

    中山書店  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 日本臨床別冊「免疫症候群(第2版)Ⅲ—その他の免疫疾患を含めて−」 Ⅶ.原発性免疫不全症候群 5.免疫調節不全症 (1)家族性血球貪食性リンパ組織球(FHL)症候群 ①Perforin欠損症(FHL2). ②UNC13D/Munc13-4欠損症(FHL3). ③Syntaxin11欠損症(FHL4). ④STXBP2/Munc18-2欠損症(FHL5).

    市村 卓也, 大賀 正一( Role: Joint author)

    日本臨牀社  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 日本臨床別冊「免疫症候群(第2版)Ⅱ—その他の免疫疾患を含めて−」 EBウイルス〜EBウイルス感染症が関与する免疫異常〜

    東 良紘, 大賀 正一( Role: Joint author)

    日本臨牀社  2016.3 

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    Language:Japanese   Book type:Scholarly book

  • 今日の治療指針2016 私はこう治療している 23小児科疾患 原発性免疫不全症.

    大賀 正一( Role: Sole author)

    医学書院  2016.3 

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    Responsible for pages:1432   Language:Japanese   Book type:Scholarly book

  • エキスパートのための産婦人科・新生児領域の血液疾患診療の手引き 2.新生児血栓症.

    大賀 正一( Role: Sole author)

    日本産婦人科新生児血液学会編集  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • CVADガイドライン.

    鈴木信寛, 工藤寿子, 小阪嘉之, 大賀 正一, 石黒精, 長江千愛, 嶋 緑倫, 瀧 正志( Role: Joint author)

    日本小児血液・がん学会血栓止血委員会編集  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 新生児DIC診断・治療指針2015年版.  

    白幡 聡, 高橋幸博, 茨 聡, 大賀 正一, 河井昌彦, 川口千晴, 沢田 健, 高橋大二郎, 瀧 正志, 長江千愛, 西久保敏也, 水上尚典, 樺山知佳( Role: Joint author)

    日本産婦人科・新生児血液学会  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 小児慢性特定疾病 11 遺伝性球状赤血球症. 12 口唇赤血球症. 13 鎌状赤血球症. 14 不安定ヘモグロビン症. 15 サラセミア. 16 グルコース-6-リン酸脱水素酵素欠乏症. 17 ピルビン酸キナーゼ欠乏性貧血. 18 11から17までに掲げるもののほか、遺伝性溶血性貧血. 19 溶血性貧血(脾機能亢進症によるものに限る。). 49 先天性プロテインC欠乏症. 50 先天性プロテインS欠乏症. 51 先天性アンチトロンビン欠乏症.

    大賀 正一, 菅野 仁( Role: Joint author)

    診断と治療社  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 小児科診療別冊, 小児の症候群, PFAPA症候群  

    長谷川俊史, 大賀 正一( Role: Joint author)

    診断と治療社  2016.3 

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    Responsible for pages:印刷中   Language:Japanese   Book type:Scholarly book

  • 3章 かぜ症候群とウイルス感染症 EBウイルス 小児科臨床ピクシス20 かぜ症候群と合併症

    大賀 正一、中本 貴人

    2010.8 

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    Responsible for pages:pp. 120-123   Book type:General book, introductory book for general audience

  • 14.免疫疾患 慢性活動性EBウイルス感染症 総合小児科診療のための小児科学レビュー2010

    土居 岳彦、大賀 正一、原 寿郎

    2010.4 

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    Responsible for pages:pp. 184-190   Book type:General book, introductory book for general audience

  • 今日の小児治療指針 第14版 「血液疾患 自己免疫性溶血性貧血」

    ( Role: Joint author)

    医学書院2005  2005.1 

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    Language:Japanese   Book type:Scholarly book

  • 今日の小児治療指針 第13版 「血液・リンパ節疾患」

    大賀正一( Role: Joint author)

    医学書院  2002.1 

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    Language:Japanese   Book type:Scholarly book

  • 小児輸血療法−安全で有効な輸血のために−

    大賀正一、稲葉頌一( Role: Joint author)

    南江堂  2001.1 

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    Responsible for pages:p75-83   Language:Japanese   Book type:Scholarly book

  • ベッドサイドの小児の診かた 第2版、第3版南山堂 「感染とこども」

    大賀正一( Role: Joint author)

    南山堂  2001.1 

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    Language:Japanese   Book type:Scholarly book

  • TcRV領域遺伝子の選択とMHC. Annual Review 免疫1991

    大賀 正一, 吉開 泰信

    中外医学社  1991.1 

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    Responsible for pages:pp. 10-20   Book type:General book, introductory book for general audience

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Presentations

  • Clinical outcomes of stem cell transplantation for childhood hemophagocytic lymphohistiocytosis (HLH/HPS) in Japan International conference

    Ohga S, Kudo K, Morimoto A, Honjo S, Osugi Y, Inoue M, Tabuchi K, Suzuki N, Ishida Y, Kawa K, Imashuku S, Hara T, Kato S and Ishii E for the HLH/LCH and SCT Committees in the Japanese Society of Pediatric Hematology

    The 4th Workshop of Asian Hematology in BangkokNRCT- JSPS Asian Core Program  2009.2 

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    Event date: 2009.2

    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Country:Thailand  

  • Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis or Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan International conference

    Shouichi Ohga, Kazuko Kudo, Yuko Osugi, Akihisa Sawada, Ken Tabuchi, Nobuhiro Suzuki, Akira Morimoto, Yasushi Ishida, Shunichi Kato, Eiichi Ishii, and The HLH/LCH and SCT Committees in the Japanese Society of Pediatric Hematology

    24th Annual Meeting of Histiocyte Society, October 1-3  2008.10 

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    Event date: 2008.10

    Country:Germany  

  • Future perspectives of newborn screening: experience from cord blood transplantation for the infants with athymic CHARGE syndrome at Kyushu University Hospital in Japan International conference

    Sonoda M, Ishimura M, Inoue H, Eguchi K, Ochiai M, Sakai Y, Doi T, Suzuki K, Inoue T, Mizukami T, Takada H, Nakamura K, Ohga S

    The 185th Congresss of Aian Society for Pediatric Research  2023.11 

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    Event date: 2023.11

    Language:English   Presentation type:Oral presentation (general)  

    Country:Japan  

    Sonoda M, Ishimura M, Inoue H, Eguchi K, Ochiai M, Sakai Y, Doi T, Suzuki K, Inoue T, Mizukami T, Takada H, Nakamura K, Ohga S:
    Future perspectives of newborn screening: experience from cord blood transplantation for the infants with athymic CHARGE syndrome at Kyushu University Hospital in Japan
    The 18th Congress of ASPR

  • 新生児医療から予防接種へ~Actionable NBSをめざして~ Invited

    大賀 正一

    第54回日本小児感染症学会総会・学術集会  2023.11 

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    Event date: 2023.11

    Language:Japanese   Presentation type:Oral presentation (general)  

    Venue:福岡   Country:Japan  

  • Diagnosing uncertainty: suspected VLCAD deficiency in an infant with two ACADVL variants of uncertain significance

    Vlad Tocan, Taro Shimamoto, Yuichi Mushimoto, Nozomi Abe, Kanako Kojima-Ishii, Shouichi Ohga

    2022.12 

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    Event date: 2022.12

    Language:English  

    Country:Japan  

  • STIM-mediated store-operated calcium entry regulates maintenance and selection of germinal center B cells

    Yutaro Yada, Masanori Matsumoto, Takeshi Inoue, Daisuke Kitamura, Tomohiro Kurosaki and Yoshihiro Baba

    2022.12 

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    Event date: 2022.12

    Language:English  

    Country:Japan  

  • 移植後に長期免疫再構築不全を呈したCD3δ欠損症兄弟に対する造血細胞再移植

    朴崇娟、江口克秀、石村匡崇、足立俊一、木下恵志郎、園田素史、高田英俊、大賀正一

    第64回日本小児血液・がん学会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Country:Japan  

  • Rhinovirus感染症に対しリバビリンとインターフェロンαの併用療法下で造血細胞移植を行った重症複合免疫不全症の乳児例

    原田頌隆、本村良知、園田素史、石村匡崇、江口克秀、木下恵志郎、松岡若利、賀来典之、大賀正一

    第54回日本小児感染症学会総会・学術集会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Country:Japan  

  • 新生児医療から予防接種へ~Actionable NBSをめざして~

    大賀正一

    第54回日本小児感染症学会総会・学術集会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Country:Japan  

  • エルシニアと川崎病

    安岡和昭、林哲也、尾内一信、原寿郎、大賀正一

    第54回日本小児感染症学会総会・学術集会  2022.11 

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    Event date: 2022.11

    Language:Japanese  

    Country:Japan  

  • A preterm-onset juvenile myelomonocytic leukemia-like myeloproliferation with PTPN11 mutation

    Yamamoto S, Nakao S, Koga Y, Inoue H, Nakashima K, Kojima-Ishii K, Semba Y, Maeda T, Akashi K, Ohga S

    The 84th Annual Meeting of the Japanese Society of Hematology  2022.10 

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    Event date: 2022.10

    Language:English  

    Country:Japan  

  • 治療抵抗性SAPHO症候群に対してJAK阻害剤を導入した3例の治療経過および免疫学的プロファイルの解析

    園田素史、石村匡崇、朴崇娟、原田頌隆、足立俊一、木下恵志郎、矢田裕太郎、江口克秀、白石暁、大賀正一

    2022.10 

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    Event date: 2022.10

    Language:Japanese  

    Country:Japan  

  • 小児ESKD患者の予後と移行期医療 移行期に留意すべき小児末期腎不全患者の身体的合併症

    西山慶、岩屋友香、大賀正一

    第67回日本透析医学会学術集会  2022.7 

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    Event date: 2022.7

    Language:Japanese  

    Country:Japan  

  • 血栓性素因スクリーニングの臨床的意義 新生児血栓症の全国調査からの洞察

    江上直樹、落合正行、市山正子、井上普介、園田素史、石村匡崇、堀田多恵子、内海健、康東天、大賀正一

    第32回日本産婦人科・新生児血液学会  2022.6 

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    Event date: 2022.6

    Language:Japanese  

    Country:Japan  

  • Diamond-Blackfan貧血に対する用量調整ブスルファンを用いた非血縁者間骨髄移植

    江口克秀、石村匡崇、田村彰広、伊藤暢宏、平野直樹、足立俊一、木下恵志郎、幸伏寛和、矢田裕太郎、園田素史、白石暁、小阪嘉之、照井君典、伊藤悦朗、大賀正一

    2022.5 

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    Event date: 2022.5

    Language:Japanese  

    Country:Japan  

  • A retrospective study of eltrombopag for the treatment of pediatric aplastic anemia and inherited bone marrow failure syndromes in Japan

    Eguchi K, Ishimura M, Ohga S:

    2021 the Korean Society of Pediatric Hematology Oncology Autumn Meeting  2021.10 

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    Event date: 2021.10

    Language:English  

    Country:Korea, Republic of  

  • The clinical expression and treatment of MALT1 deficiency due to a novel nonsense mutation.

    Sonoda M, Ishimura M, Eguchi K, Yada Y, Shiraishi A, Ohga S:

    The 83rd Annual Meeting of Japanese Society of Hematology  2021.9 

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    Event date: 2021.9

    Language:English  

    Country:Japan  

  • The onset and relapse of pediatric leukemia: How did it get to here?" Environmental factors for the development of hematopoietic neoplasms in childhood International conference

    Koga Y, Sanefuji M, Tanimura M, Bessho F, Ohga S

    The 82nd Annual Meeting of the Japanese Society of Hematology (JSH2020)  2020.10 

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    Event date: 2020.10

    Language:English  

    Country:Japan  

  • Involvement of cytotoxic T lymphocytes and natural killer cells in Henoch-Schönlein purpura nephritis. International conference

    2019.10 

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    Event date: 2019.10 - 2020.10

    Language:English  

    Country:Italy  

  • Hepatocyte-Like-Cells converted from stem cells from human exfoliated deciduous teeth for a novel cell therapy for fulminant Wilson’s disease. International conference

    2019.9 

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    Event date: 2019.9 - 2020.9

    Language:English  

    Country:Japan  

  • Epstein-Barr Virus-Associated Immunodeficiency Diseases. Invited International conference

    Ohga Shouichi

    Spring conference of Korean Society of Pediatric Infectious Diseases 2018  2018.5 

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    Event date: 2018.5

    Language:English  

    Country:Korea, Republic of  

  • Diagnostic challenge of heritable protein C deficiency in the newborn infants International conference

    Ichiyama M, Inoue H, Ochiai M, Ishimura M, Shiraishi A, Fujiyoshi J, Yamashita H, Sato K, Matsumoto S, Hotta T, Uchiumi T, Kang T, Nishikubo T, Ishiguro A, Ohga S

    Pediatric Academic Societies Meeting; 2018 May 8, 2018; Toronto CANADA  2018.5 

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    Event date: 2018.5

    Language:English  

    Country:Japan  

  • 新生児・乳児に発症する特発性血栓症の病態解明および治療管理法と根治療法の確立に関する研究

    大賀正一、市山正子 、落合正行 、石村匡崇 、石黒精 、末延聡一 、山座孝義 、西久保敏也 、嶋緑倫 、堀田多恵子 、内海健 、康東天

    難治性疾患実用化研究事業、免疫アレルギー疾患など実用化研究事業 2017年度合同成果報告会  2018.2 

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    Event date: 2018.2

    Language:Japanese  

    Venue:横浜   Country:Japan  

  • 新生児と小児期に発症する遺伝性血栓症~分子疫学から診断と治療まで~

    大賀正一

    第39回日本血栓止血学会学術集会  2017.6 

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    Event date: 2017.6

    Language:Japanese  

    Country:Japan  

  • 日本人における遺伝性血栓症~新生児・小児と成人の比較~

    市山正子、石村匡崇、#落合正行、井上裕文、#井上普介、楠田剛、金城唯宗、高畑靖、内海健、堀田多恵子、康東天、大賀正一

    第9回福岡県医学会総会  2017.2 

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    Event date: 2017.2

    Language:Japanese  

    Country:Japan  

  • 小児の血栓症 わが国の遺伝性血栓症 -PC/PS/AT 欠乏症を中心に-

    石村匡崇、大賀正一

    第59回日本小児血液・がん学会  2017.1 

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    Event date: 2017.1

    Language:Japanese  

    Country:Japan  

  • 早産児における出生時と1生月の血清プロヘプシジン値

    北島順子、井上晋介、楠田剛、後藤貴子、金城唯宗、落合正行、高畑靖、井原健二、大賀正一、原寿郎、本荘哲

    第52回日本小児血液学会  2010.12 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • 未熟児・新生児におけるProhepcidinとその意義

    北島順子、井上普介、金城唯宗、後藤貴子、落合正行、高畑靖、井原健二、本荘哲、大賀正一、原寿郎

    第162回福岡血液懇話会  2010.1 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • 日本における家族性血球貪食性リンパ組織球症の実態とその多様性

    永井功造、田内久道、石井榮一 山本健 藤原弘、越智俊元、末盛浩一郎、安川正貴  大賀正一

    第3回 日本免疫不全症研究会  2010.1 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • 慢性活動性EBウイルス感染症患者の感染細胞源に関する検討

    大賀正一、石村匡崇、土居岳彦、高田英俊、吉本五一、宮本敏浩、安部康信、今留謙一、大島孝一、赤司浩一、原寿郎

    第20回EBウイルス感染症研究会  2010.3 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • EBウイルス関連T/NKリンパ増殖性疾患モデルマウスの作製と病態発現解析

    今留謙一、矢島美彩子、川野布由子、中川温子、新井文子、市川紗弓、森尾友宏、大賀正一、大石勉、清水則夫、山本直樹、藤原成悦

    第20回EBウイルス感染症研究会  2010.3 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • 日本における家族性血球貪食性リンパ組織球症の実態とその多様性

    永井功造、山本健、藤原弘、越智俊元、末盛浩一郎、田内久道、大賀正一、石井榮一、安川正貴

    第6回血球貪食症候群研究会  2010.3 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • ループス関連血球貪食症候群の治療中に心房細動をきたした一例

    西山慶、山村健一郎、土居岳彦、佐藤薫、堤康、池田和幸、藤島章義、須田正洋、高田英俊、大賀正一、原寿郎

    第6回血球貪食症候群研究会  2010.3 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • プロテインC(PC)欠損症による電撃性紫斑病と当院における血栓症の病因解析システム

    渡邉久美子、井上望、林真実、浦田美秩代、栢森裕三、康東天、石村匡崇、大賀正一

    第20回生物試料分析科学会年次学術集会  2010.3 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • 早産児における出生時と1生月の血清プロヘプシジン値

    北島順子、松本直子、日高靖文、高畑 靖、落合正行、大賀正一、原寿郎、本荘哲

    第459回日本小児科学会福岡地方会例会  2010.4 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • 早産児の新生児期における血清ケモカイン値と3歳時の発達

    金城唯宗、井上普介、後藤貴子、落合正行、田中珠美、高畑靖、井原健二、大賀正一、原寿郎、本荘哲

    第459回日本小児科学会福岡地方会例会  2010.4 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • メチルプレドニゾロンパルス療法中に心房細動を繰り返したループス関連血球貪食症候群の1例

    西山慶、山村健一郎、土居岳彦、堤康、池田和幸、高田英俊、大賀正一、原寿郎

    第459回日本小児科学会福岡地方会例会  2011.4 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • 新規NEMO遺伝子異常によるMendelian susceptibility to mycobacterial infection

    高田英俊、金澤 崇、保科隆之、石村匡崇、土居岳彦、大賀正一、河合朋樹、西小森 隆太、荒川浩一、中畑龍俊、原寿郎

    第113回日本小児科学会学術集会  2010.4 

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    Event date: 2011.5

    Venue:盛岡   Country:Japan  

  • リウマチ性疾患との鑑別を要したFabry病の一例

    土居岳彦、高田英俊、伊藤雄哉、島袋渡、石崎義人、水野由美、中村公俊、大賀正一、原寿郎

    第2回KOCS小児リウマチ研究会  2010.6 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • 早産児における出生時と1生月の血清プロヘプシジン値

    北島順子、井上晋介、楠田剛、後藤貴子、金城唯宗、落合正行、高畑靖、井原健二、大賀正一、原寿郎、本荘哲

    北島順子、井上晋介、楠田剛、後藤貴子、金城唯宗、落合正行、高畑靖、井原健二、大賀正一、原寿郎、本荘哲  2010.6 

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    Event date: 2011.5

    Venue:浜松   Country:Japan  

  • 停留精巣術後に術後出血で気付かれた血友病Bの1例

    宗崎良太、木下義晶、林田真、田尻達郎、土居岳彦、大賀正一、原寿郎、田口智章

    第19回日本小児泌尿器科学会総会  2010.6 

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    Event date: 2011.5

    Venue:札幌   Country:Japan  

  • Clonal origin of EB virus-infected T/NK-cells in chronic active EB virus infection.

    Ohga S, Ishimura M, Doi T, Takada H, Yoshimoto G, Miyamoto T, Abe Y, Imadome K, Ohshima K, Akashi K, Hara T

    2010.9 

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    Event date: 2011.5

    Country:Japan  

  • Four adult cases of chronic active Epstein-Barr virus (EBV) infection.

    Abe Y, Shiratsuchi M, Nagasawa E, Ohno H, Sada E, Ohba R, Matsushima T, Ohga S, Takayanagi R, Ohshima K

    2010.9 

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    Event date: 2011.5

    Country:Japan  

  • Hemophagocytic lymphohistiocytosis after stem cell transplantation in children: nationwide survey.

    Asano T, Kogawa K, Morimoto A, Ishida Y, Suzuki N, Ohga S, Kudoh K, Ohta S, Wakiguchi H, Tabuchi K, Katoh S, Ishii E

    2010.9 

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    Event date: 2011.5

    Country:Japan  

  • Diamond Blackfan貧血に関する新規の病因候補遺伝子同定

    菅野仁、山本俊至、大賀正一、立石浩、濱田貴子、槍澤大樹、小倉浩美、藤井寿一

    第72回日本血液学会  2010.9 

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    Event date: 2011.5

    Venue:横浜   Country:Japan  

  • 自己免疫性甲状腺機能低下症とIgA欠損症を認めた環状18番染色体症候群の一例

    大久保 一宏、井原 健二、野﨑 高史、牧村 美佳、石井 加奈子、大賀 正一、原 寿郎

    第44回日本小児内分泌学会学術集会  2010.10 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • 慢性肉芽腫症症例に対する播種性BCG感染症を中心とした抗酸菌感染症治療指針作成の提案

    保科隆之 土居岳彦 瀧本智仁、高田英俊 大賀正一 原寿郎、水上智之

    第18回 食細胞機能異常研究会  2010.12 

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    Event date: 2011.5

    Venue:東京   Country:Japan  

  • 播種性BCG感染症を契機に慢性肉芽腫症と診断した1例

    大場詩子、土居岳彦、保科隆之、瀧本智仁、大賀正一、高田英俊、原寿郎、水野由美、大楠清文

    第462回日本小児科学会福岡地方会  2010.12 

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    Event date: 2011.5

    Venue:福岡   Country:Japan  

  • 慢性活動性EBウイルス感染症における感染細胞の起源に関して

    大賀正一、石村匡崇、土居岳彦、高田英俊、原寿郎

    第52回日本小児血液学会  2010.12 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • ステロイドパルス療法が奏功したGraves病合併再生不良性貧血の一例

    石村匡崇、大賀正一、宇都宮里奈、牧村美佳、土居岳彦、井原健二、原 寿郎

    第52回日本小児血液学会  2010.12 

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    Event date: 2011.5

    Venue:大阪   Country:Japan  

  • EBV関連及び家族性血球貪食性リンパ組織球症に対する造血細胞移植の成績

    大賀正一, 工藤寿子, 森本哲, 大杉夕子, 澤田明久, 田淵健, 本荘哲, 原寿郎, 加藤俊一, 石井榮一

    第112回 日本小児科学会学術集会  2009.4 

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    Event date: 2009.4

    Presentation type:Oral presentation (general)  

    Venue:奈良   Country:Japan  

  • Genotype-phenotype correlation in 3 subtypes of familial hemophagocytic lymphohistiocytosis (FHL) patients International conference

    Ueda I, Ishii E, Yamamoto K, Ohga S, Sako M, Yasukawa M, Inaba T, Hibi S, Takada H, Hara T, Sugimoto T, Morimoto A, Imashuku S, Japan HLH Study Group

    20th Annual Meeting of the Histiocyte Society 2004 Sep 12-14, Stockholm  2004.12 

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    Presentation type:Oral presentation (general)  

    Country:Sweden  

  • 貧血とモもやもや症候群モ:摘脾2症例の経験から

    大賀正一、野村明彦、高田英俊、実藤雅文、鳥巣浩幸、吉良龍太郎、水田祥代、原寿郎

    第46回日本小児血液学会 2004年11月22-23日 京都  2004.11 

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    Presentation type:Oral presentation (general)  

    Venue:京都   Country:Japan  

  • 小児の貧血 〜先天性骨髄不全症を中心に〜 第17回博多シンポジウム「血液疾患、新生から再生治療への展開」 Invited

    大賀正一

    第17回博多シンポジウム  2004.11 

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    Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • EBウイルス関連疾患の診断と治療〜慢性活動性EBV感染症を中心に〜 Invited

    大賀正一、石村匡崇、東保大海、菅尚浩、野村明彦、高田英俊、原寿郎

    2004.7 

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    Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • Blackfan-Diamond症候群の病態と治療 Invited

    大賀正一,古賀友紀,野村明彦,高田英俊,原寿郎

    第9回小児血液セミナー 2004年10月22日 福岡  2004.10 

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    Presentation type:Oral presentation (invited, special)  

    Venue:福岡   Country:Japan  

  • 3回の造血幹細胞移植後に寛解を維持している重症CAEBVの1例

    大賀正一、野村明彦、東保大海、石村匡崇、森鼻栄治、井手誠、斎藤祐介、西尾壽乗、高田英俊、原 寿郎

    第27回日本造血細胞移植学会 2004年12月16-17日 岡山  2004.12 

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    Presentation type:Oral presentation (general)  

    Venue:岡山   Country:Japan  

▼display all

MISC

  • 【血液症候群(第3版)-その他の血液疾患を含めて-】リンパ系の腫瘍 組織球性疾患 非腫瘍性組織球症 遺伝性血球貪食性リンパ組織球症

    江口 克秀, 石村 匡崇, 大賀 正一

    日本臨床別冊血液症候群血液症候群IV   2024.2

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    Language:Japanese  

  • 小児神経と生命倫理学 生命倫理学と小児神経学のトランスレーション

    笹月 桃子, トカン・ヴラッド , 酒井 康成, 吉良 龍太郎, 大賀 正一

    脳と発達   2024.1

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【子どもの検査値の判断に迷ったら】(5章)血液凝固・線溶系検査 検査の種類と原理・読み取り方とその限界

    江上 直樹, 石村 匡崇, 堀田 多恵子, 大賀 正一

    2023.12

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 貧血 溶血性貧血 後天性溶血性貧血 免疫性溶血性貧血 同種免疫性溶血性貧血 新生児溶血性貧血(解説)

    落合正行、大賀正一

    日本臨床別冊血液症候群I   2023.9

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  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 鉄過剰症 新生児鉄過剰症

    坂口 嘉彬, 井上 普介, 大賀 正一

    日本臨床別冊血液症候群   2023.9

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  • 【匠から学ぶ 血栓止血検査ガイド】(5章)疾患まとめ 小児領域のDIC(解説)

    江上 直樹, 落合 正行, 石村 匡崇, 大賀 正一

    検査と技術   2023.9

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  • 栓友病と遺伝性血栓性素因 母子を守る個別医療へ

    大賀 正一, 江上 直樹, 堀田 多恵子, 内海 健, 落合 正行, 石村 匡崇

    臨床血液   2023.9

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  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 鉄過剰症 新生児鉄過剰症

    坂口 嘉彬, 井上 普介, 大賀 正一

    日本臨床別冊血液症候群I   2023.9

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    Language:Japanese   Publishing type:Article, review, commentary, editorial, etc. (scientific journal)  

  • 【血液症候群(第3版)-その他の血液疾患を含めて-】赤血球の異常 貧血 その他の貧血 未熟児貧血

    隈本 大智, 井上 普介, 大賀 正一

    日本臨床別冊血液症候群I   2023.9

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  • RelAの優性阻害変異により,自己炎症や自己免疫疾患をきたす(Dominant negative RelA mutation causes autoinflammatory and autoimmune disorders)

    森谷 邦彦, 中野 智太, 本田 吉孝, 園田 素史, 津村 弥来, 内田 崇, 石村 匡崇, 井澤 和司, 角田 文彦, 虻川 大樹, 八角 高裕, 岡田 賢, 大賀 正一, 笹原 洋二, 呉 繁夫

    日本小児科学会雑誌   2021.2

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  • Long-term outcomes of children with extracutaneous juvenile xanthogranulomas in Japan Reviewed

    , Miho Maeda, Akira Morimoto, Yoko Shioda, Takeshi Asano, Yuhki Koga, Yozo Nakazawa, Hirokazu Kanegane, Kazuko Kudo, Shouichi Ohga, Eiichi Ishii

    Pediatric Blood and Cancer   2020.7

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    DOI: 10.1002/pbc.28381

  • Exploratory analysis of plasma cytokine/chemokine levels in 6-year-old children from a birth cohort study Reviewed

    Kiwako Yamamoto-Hanada, Eiryo Kawakami, Mayako Saito-Abe, Miori Sato, Hiroshi Mitsubuchi, Masako Oda, Takahiko Katoh, Masafumi Sanefuji, Shouichi Ohga, Mari Kuwajima, Nathan Mise, Akihiko Ikegami, Fujio Kayama, Ayako Senju, Masayuki Shimono, Koichi Kusuhara, Shin Yamazaki, Shoji F. Nakayama, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya

    Cytokine   2020.6

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    Language:English  

    DOI: 10.1016/j.cyto.2020.155051

  • Associations of dog and cat ownership with wheezing and asthma in children Pilot study of the Japan Environment and children’s study Reviewed

    2020.5

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    Objectives No previous study has used repeated measures data to examine the associations of dog/ cat ownership with wheezing and asthma prevalence among children. This prospective study used repeated measurers analysis to determine whether dog/cat ownership in childhood is an independent risk factor for wheezing and asthma, after adjustment for gestational, socio-economical, and demographical confounders confounders, in Japan. Methods We conducted a multicenter pilot study of the Japan Environment and Children’s Study (JECS) during 2009–2010. Among 440 newborn infants enrolled, 410 (52.8% males) were evaluated for dog/cat ownership in the home and history of wheezing and asthma in five follow-up questionnaire surveys (until age 6 years). Dog/cat ownership during follow-up period was categorized into four groups: 7.6% were long-term dog/cat owners, 5.9% were toddler-age owners, 5.9% were preschool-age owners, and 80.7% were never owners. Results The prevalence of wheezing during follow-up period increased from 20.8% to 35.4% and the prevalence of asthma increased from 1.3% to 16.3%. A fitted logistic generalized estimating equation models including important confounders showed no significant associations of the interaction between dog and/or cat ownership and follow-up time with the risks of wheezing and asthma. However, the risks of wheezing and asthma were slightly lower for long-term and toddler-age dog/cat owners than for preschool-age and never owners. Conclusions The present findings suggest that dog and cat ownership from toddler-age does not increase the risks of wheezing and asthma compared with never owners among Japanese children.

    DOI: 10.1371/journal.pone.0232604

  • Poly- and perfluoroalkyl substances in maternal serum Method development and application in Pilot Study of the Japan Environment and Children's Study Reviewed

    Shoji F. Nakayama, Tomohiko Isobe, Miyuki Iwai-Shimada, Yayoi Kobayashi, Yukiko Nishihama, Yu Taniguchi, Makiko Sekiyama, Takehiro Michikawa, Shin Yamazaki, Hiroshi Nitta, Masako Oda, Hiroshi Mitsubuchi, Masafumi Sanefuji, Shouichi Ohga, Nathan Mise, Akihiko Ikegami, Reiko Suga, Masayuki Shimono

    Journal of Chromatography A   2020.5

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    DOI: 10.1016/j.chroma.2020.460933

  • De novo p.G696S mutation in COL4A1 causes intracranial calcification and late-onset cerebral hemorrhage A case report and review of the literature COL4A1-associated vasculopathy Reviewed

    Keishiro Kinoshita, Yoshito Ishizaki, Hiroyuki Yamamoto, Motoshi Sonoda, Kousuke Yonemoto, Ryutaro Kira, Masafumi Sanefuji, Akihiko Ueda, Hirotaka Matsui, Yukio Ando, Yasunari Sakai, Shouichi Ohga

    European Journal of Medical Genetics   2020.4

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    DOI: 10.1016/j.ejmg.2019.103825

  • Utility of Soluble CD163 in the Clinical Management of Patients With Kawasaki Disease Reviewed

    Yoshihiro Azuma, Yasuo Suzuki, Seigo Okada, Chie Matsuguma, Hiroyuki Wakiguchi, Yuji Ohnishi, Takashi Furuta, Akiko Miyake, Hiroki Yasudo, Kiyoshi Ichihara, Shouichi Ohga, Shunji Hasegawa

    Frontiers in Pediatrics   2020.4

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    Language:English  

    DOI: 10.3389/fped.2020.00148

  • The expanding phenotype of hypokalemic periodic paralysis in a Japanese family with p.Val876Glu mutation in CACNA1S Reviewed

    Mari Kurokawa, Michiko Torio, Kazuhiro Ohkubo, Vlad Tocan, Noriko Ohyama, Naoko Toda, Kanako Ishii, Kei Nishiyama, Yuichi Mushimoto, Ryuichi Sakamoto, Maki Nakaza, Riho Horie, Tomoya Kubota, Masanori P. Takahashi, Yasunari Sakai, Masatoshi Nomura, Shouichi Ohga

    Molecular Genetics and Genomic Medicine   2020.4

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    DOI: 10.1002/mgg3.1175

  • Gastrointestinal symptoms as an extended clinical feature of Pierson syndrome A case report and review of the literature Reviewed

    Kei Nishiyama, Mari Kurokawa, Michiko Torio, Yasunari Sakai, Mitsuru Arima, Shoko Tsukamoto, Satoshi Obata, Shogo Minamikawa, Kandai Nozu, Noriyuki Kaku, Yoshihiko Maehara, Koh Hei Sonoda, Tomoaki Taguchi, Shouichi Ohga

    BMC Medical Genetics   2020.4

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    DOI: 10.1186/s12881-020-01019-9

  • 代理意思決定における小児科医の葛藤と役割

    笹月 桃子, 酒井 康成, 吉良 龍太郎, 戸田 尚子, 一宮 優子, 赤峰 哲, 鳥尾 倫子, 石崎 義人, 實藤 雅文, 奈良間 美保, 板井 孝壱郎, 原 寿郎, 高田 英俊, 木澤 義之, 大賀 正一

    日本小児科学会雑誌   2020.2

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  • A case of acute encephalophathy with residual neurological sequelae induced by immunoglobulin A vasculitis.

    Hiroki Hamano, Takeshi Matsushige, Hirofumi Inoue, Madoka Hoshide, Hikaru Kobayashi, Fumitaka Kohno, Momoko Oka, Takashi Ichiyama, Shouichi Ohga, Kazunobu Ouchi, Shunji Hasegawa

    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia   2019.9

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    DOI: 10.1016/j.jocn.2019.05.061

  • Nontuberculous mycobacteria-associated hemophagocytic lymphohistiocytosis in MonoMAC syndrome

    Katsuhide Eguchi, Masataka Ishimura, Motoshi Sonoda, Hiroaki Ono, Akira Shiraishi, Shunsuke Kanno, Yuhki Koga, Hidetoshi Takada, Shouichi Ohga

    Pediatric Blood and Cancer   2018.7

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    DOI: 10.1002/pbc.27017

  • A Review of 50 Cases of Rhabdomyosarcoma Treated Between 1990-2017: A Report from the Single Institution

    Yoshiaki Kinoshita, Yuki Koga, Ryota Souzaki, Naonori Kawakubo, Minori Ishi, Utako Oba, Hidetoshi Takada, Yuichi Shibui, Junkichi Takemoto, Kenichi Kohashi, Yoshinao Oda, Shouichi Ohga, Tomoaki Taguchi

    PEDIATRIC BLOOD & CANCER   2017.11

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  • 【外科の近未来-1,000号記念】 近未来の再生医療と外科 肝再生医療の展望と乳歯歯髄幹細胞

    田口 智章, 山座 孝義, 松浦 俊治, 高橋 良彰, 岩中 剛, 柳 佑典, 吉丸 耕一郎, 山座 治義, 野中 和明, 中山 功一, 小林 英司, 大賀 正一

    外科   2017.11

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    乳歯歯髄幹細胞(SHED)は幹細胞として理想的なもので,造腫瘍性のリスクはなく,多分化能,細胞分裂能に優れ,免疫寛容性も有している.SHEDを使った肝細胞移植およびミニ肝移植や大きな肝臓を作成することにより,肝移植の代替治療として低侵襲で安全な治療法の開発が期待される.成人でも智歯(おやしらず)から歯髄幹細胞を採取することができるので今後適応範囲は広がるものと期待される.歯髄幹細胞を細胞源とする再生医療は外科治療に無限の可能性を提供してくれるであろう.(著者抄録)

    DOI: 10.15106/j_geka79_1023

  • Two Neonatal Patients with Systemic Herpes Simplex Virus-associated Hemophagocytic lymphohistiocytosis

    Motoshi Sonoda, Masataka Ishimura, Katsuhide Eguchi, Akira Shiraishi, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   2017.11

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  • Hematopoietic Stem Cell Transplantation with Targeted Busulfan-containing Regimen for Diamond-Blackfan Anemia

    Katsuhide Eguchi, Masataka Ishimura, Motoshi Sonoda, Akira Shiraishi, Hidetoshi Takada, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   2017.11

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  • エキスパートのための産婦人科・新生児領域の血液疾患診療の手引き 2.新生児血栓症

    大賀正一

    2017.7

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  • Clarithromycin Plus Intravenous Immunoglobulin Therapy Can Reduce the Relapse Rate of Kawasaki Disease: A Phase 2, Open-Label, Randomized Control Study.

    Etsuro Nanishi, Hisanori Nishio, Hidetoshi Takada, Kenichiro Yamamura, Mitsuharu Fukazawa, Kenji Furuno, Yumi Mizuno, Kenjiro Saigo, Ryo Kadoya, Noriko Ohbuchi, Yasuhiro Onoe, Hironori Yamashita, Hideki Nakayama, Takuya Hara, Takuro Ohno, Yasuhiko Takahashi, Ken Hatae, Tatsuo Harada, Takayuki Shimose, Junji Kishimoto, Shouichi Ohga, Toshiro Hara

    Journal of the American Heart Association   2017.7

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    DOI: 10.1161/JAHA.116.005370

  • 小児外科領域の先端的医療の展開(II):先端治療開発の方向性 乳歯幹細胞を用いた肝再生研究

    柳佑典, 山座孝義, 山座治義, 野中和明, 中山功一, 吉丸耕一朗, 岩中剛, 高橋良彰, YUNIARTHA Rathi, 松浦俊治, 孝橋賢一, 小田義直, 大賀正一, 絵野沢伸, 小林英司, 田口智章

    小児外科   2017.6

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  • 異臭便のMorganella morganiiに関連したスルフヘモグロビン血症疑いの早産児例

    尾上 泰弘, 倉田 浩昭, 菅 尚浩, 井上 裕規, 齋藤 光正, 山城 安啓, 石村 匡崇, 大賀 正一

    日本小児科学会雑誌   2017.2

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  • 【貧血性疾患診療の進歩】 先天性溶血性貧血の遺伝子診断

    大賀 正一, 山城 安啓, 菅野 仁

    血液内科   2016.8

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  • ATP11C Encodes a Major Flippase in Human Erythrocyte and Its Genetic Defect Causes Congenital Non-Spherocytic Hemolytic Anemia

    Nobuto Arashiki, Yuichi Takakuwa, Hiromi Ogura, Taiju Utsugisawa, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Shouichi Ohga, Narla Mohandas, Hitoshi Kanno

    BLOOD   2015.12

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  • Long-lasting non-IgE-mediated gastrointestinal cow's milk allergy in infants with Down syndrome

    Hiroyuki Wakiguchi, Shunji Hasegawa, Hidenobu Kaneyasu, Madoka Kajimoto, Yousuke Fujimoto, Reiji Hirano, Shunsaku Katsura, Kenji Matsumoto, Takashi Ichiyama, Shouichi Ohga

    PEDIATRIC ALLERGY AND IMMUNOLOGY   2015.12

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    DOI: 10.1111/pai.12351

  • COL4A1 is a Novel Causative Gene Responsible for Congenital Hemolytic Anemia, Representing Characteristic Clinical Course in Infants

    Hiromi Ogura, Shouichi Ohga, Takako Aoki, Taiju Utsugisawa, Hidehiro Takahashi, Asayuki Iwai, Kenichiro Watanabe, Yusuke Okuno, Kenichi Yoshida, Satoru Miyano, Seishi Ogawa, Seiji Kojima, Hitoshi Kanno

    BLOOD   2015.12

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  • Increased Neutrophil Counts and Serum Transforming Growth Factor-beta 1 Levels in an Infant With Autoimmune Neutropenia Who Recovered From Kawasaki Disease

    Seigo Okada, Shunji Hasegawa, Yasuo Suzuki, Midori Wakabayashi, Takuya Ichimura, Hidenobu Kaneyasu, Maiko Shimomura, Kazuhiro Nakamura, Masao Kobayashi, Shouichi Ohga

    CIRCULATION   2015.4

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  • Increased Neutrophil Counts and Serum Transforming Growth Factor-beta 1 Levels in an Infant With Autoimmune Neutropenia Who Recovered From Kawasaki Disease

    Seigo Okada, Shunji Hasegawa, Yasuo Suzuki, Midori Wakabayashi, Takuya Ichimura, Hidenobu Kaneyasu, Maiko Shimomura, Kazuhiro Nakamura, Masao Kobayashi, Shouichi Ohga

    CIRCULATION   2015.4

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  • Elevated Red Cell Reduced Glutathione Is a Novel Biomarker of Diamond-Blackfan Anemia

    Taiju Utsugisawa, Toshitaka Uchiyama, Hiromi Ogura, Takako Aoki, Isao Hamaguchi, Akira Ishiguro, Akira Ohara, Seiji Kojima, Shouichi Ohga, Etsuro Ito, Hitoshi Kanno

    BLOOD   2014.12

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  • Tachyarrhythmia-induced Cerebral Sinovenous Thrombosis in a Neonate Without Cardiac Malformation

    Wakato Matsuoka, Kenichiro Yamamura, Kiyoshi Uike, Hazumu Nagata, Shouichi Ohga, Toshiro Hara

    PEDIATRICS AND NEONATOLOGY   2014.10

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    DOI: 10.1016/j.pedneo.2014.02.003

  • Risk Factors For Clonal Evolution Of Acquired Bone Marrow Failure After Immunosuppressive Therapy In Children

    Asahito Hama, Hideki Muramatsu, Masafumi Ito, Yoshiyuki Kosaka, Masahiro Tsuchida, Yoshiyuki Takahashi, Ryoji Kobayashi, Etsuro Ito, Hiromasa Yabe, Shouichi Ohga, Akira Ohara, Seiji Kojima

    BLOOD   2013.11

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    DOI: 10.1182/blood.V122.21.2473.2473

  • 新鮮凍結血漿定期投与を行ったUpshaw-Schulman症候群の長期腎予後についての検討

    井藤 奈央子, 大賀 正一, 土居 岳彦, 石村 匡崇, 野村 明彦, 高田 英俊, 菅 尚浩, 郭 義胤, 波多江 健, 松本 雅則, 藤村 吉博, 原 寿郎

    日本小児腎臓病学会雑誌   2013.5

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  • 新鮮凍結血漿定期投与を行ったUpshaw-Schulman症候群の長期腎予後についての検討

    井藤 奈央子, 大賀 正一, 土居 岳彦, 石村 匡崇, 野村 明彦, 高田 英俊, 菅 尚浩, 郭 義胤, 波多江 健, 松本 雅則, 藤村 吉博, 原 寿郎

    日本腎臓学会誌   2013.4

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  • 定期凍結血漿投与を行ったUpshaw-Schulman症候群3例の長期予後

    土居 岳彦, 大賀 正一, 井藤 奈央子, 石村 匡崇, 菅 尚浩, 野村 明彦, 松本 雅則, 藤村 吉博, 高田 英俊, 原 寿郎

    日本小児科学会雑誌   2013.2

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  • Identification of Two New DBA Genes, RPS27 and RPL27, by Whole-Exome Sequencing in Diamond-Blackfan Anemia Patients

    Etsuro Ito, Kenichi Yoshida, Yusuke Okuno, Aiko Sato-Otsubo, Tsutomu Toki, Satoru Miyano, Yuichi Shiraishi, Kenichi Chiba, Kiminori Terui, RuNan Wang, Tomohiko Sato, Yuji Iribe, Shouichi Ohga, Madoka Kuramitsu, Isao Hamaguchi, Akira Ohara, Kazuko Kudo, Isamu Kamimaki, Junichi Hara, Kanji Sugita, Kousaku Matsubara, Kenichi Koike, Akira Ishiguro, Yoshifumi Kawano, Hitoshi Kanno, Seiji Kojima, Seishi Ogawa

    BLOOD   2012.11

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  • Upshaw-Schulman症候群3例における定期凍結血漿補充の長期効果

    土居 岳彦, 菅 尚浩, 石村 匡崇, 野村 明彦, 高田 英俊, 松本 雅則, 藤村 吉博, 大賀 正一, 原 寿郎

    日本小児血液・がん学会学術集会・日本小児がん看護学会・公益財団法人がんの子どもを守る会公開シンポジウムプログラム総会号   2012.11

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  • 本邦における骨髄不全症候群の現況 先天性赤芽球癆(Diamond-Blackfan貧血)の効果的診断法の確立に関する研究

    伊藤 悦朗, 照井 君典, 土岐 力, 小島 勢二, 小原 明, 大賀 正一, 森尾 友宏, 倉光 球, 菅野 仁, 佐藤 亜以子, 小川 誠司, 浜口 功

    日本小児血液・がん学会雑誌   2012.10

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    Diamond-Blackfan貧血(DBA)は、乳児期に発症する稀な先天性赤芽球癆である。約40%に種々の先天異常を合併する。欧米では約50%のDBA患者にリボソームタンパク(RP)遺伝子の変異が認められるが、本邦のDBA患者のRP遺伝子変異の頻度は不明であった。我々は、本邦で発症した83例のDBA患者(76例の発端者)の末梢血からDNAを抽出し、DBAで遺伝子変異が報告されている8遺伝子を解析した。その結果、RPS19遺伝子変異が10例(8家系)、RPL5変異は6例(6家系)、RPL11変異は4例(4家系)で検出された。RPS10、RPS17とRPS26変異は、それぞれ1例(1家系)に認められた。興味深いことに、RPL5変異をもつ患者は6例中5例が身体的異常を合併し、そのうちの2例は口蓋裂を合併していた。次に、通常のシークエンス解析では片アレル欠失は検出できないため、定量的PCR法を用いた新規の片アレル欠失検出法を開発し、原因遺伝子が不明である27症例の解析を行った。その結果、片アレル欠失を7例(25.9%)に認めた。片アレル欠失はRPS17(3例)、RPS19(2例)、RPL5(1例)、RPL35a(1例)であった。以上、本邦におけるDBAの発端者76例中28例(36.8%)にRP遺伝子の変異を認めた。DBAの効果的診断法の確立のためには、さらに新規原因遺伝子の解明と信頼できるバイオマーカーの同定が必要である。(著者抄録)

  • Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia Reviewed

    Kuramitsu M, Sato-Otsubo A, Morio T, Takagi M, Toki T, Terui K, Wang R, Kanno H, Ohga S, Ohara A, Kojima S, Kitoh T, Goi K, Kudo K, Matsubayashi T, Mizue N, Ozeki M, Masumi A, Momose H, Takizawa K, Mizukami T, Yamaguchi K, Ogawa S, Ito E, Hamaguchi I

    Blood   2012.3

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    DOI: 10.1182/blood-2011-07-368662

  • Comparison of Clinical Outcome Between Children with Aplastic Anemia and Refractory Cytopenia of Childhood Who Received Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine

    Asahito Hama, Hideki Muramatsu, Masafumi Ito, Masahiro Tsuchida, Hirotoshi Sakaguchi, Sayoko Doisaki, Makito Tanaka, Akira Shimada, Yoshiyuki Takahashi, Ryoji Kobayashi, Etsuro Ito, Hiromasa Yabe, Shouichi Ohga, Akira Ohara, Seiji Kojima

    BLOOD   2011.11

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  • Stem cell transplantation for pediatric malignancyHemophagocytic lymphohistiocytosis.

    Ohga S, Ishii E, Takada H, Hara T

    15th Congress of Asia-Pacific Blood and Marrow Transplantation   2010.10

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  • 特集企画 血液疾患の診かた―血液専門医以外のための血液疾患対応マニュアル― 血球貪食症候群

    大賀 正一

    プライマリ・ケア医のための総合誌「治療」   2010.10

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  • Comparison of three preparative regimens in alternative donor transplant for aplastic anaemia in Japan

    H. Yabe, A. Ohara, F. Bessyo, T. Nakahata, R. Kobayashi, M. Tsuchida, S. Ohga, Y. Kosaka, H. Mugishima, A. Morimoto, E. Ito, S. Kojima

    BONE MARROW TRANSPLANTATION   2010.3

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  • Hematopoietic stem cell transplantation for familial hemophagocytic lymphohistiocytosis and Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in Japan Reviewed

    Ohga S, Kudo K, Ishii E, Honjo S, Morimoto A, Osugi Y, Sawada A, Inoue M, Tabuchi K, Suzuki N, Ishida Y, Imashuku S, Kato S, Hara T

    Pediatr Blood Cancer   2010.2

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    DOI: 10.1002/pbc.22310

  • 新規NEMO遺伝子異常によるMendelian susceptibility to mycobacterial infection

    高田 英俊, 金澤 崇, 保科 隆之, 土居 岳彦, 大賀 正一, 河合 朋樹, 西小森 隆太, 荒川 浩一, 中畑 龍俊, 原 寿郎

    日本小児科学会雑誌   2010.2

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  • Mutations in Ribosomal Protein Genes of Diamond-Blackfan Anemia Patients in Japan

    Yuki Konno, Tsutomu Toki, Satoru Tandai, Gang Xu, Kiminori Terui, Shouichi Ohga, Seiji Kojima, Ryu Yanagisawa, Kenichi Koike, Daiichiro Hasegawa, Yoshiyuki Kosaka, Rie Kanei, Tsuyoshi Imai, Teruaki Hongo, Myoung-Ja Park, Arata Watanabe, Etsuro Ito

    BLOOD   2009.11

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  • NATIONWIDE SURVEY OF SINGLE SYSTEM SINGLE SITE (SS-S) LANGERHANS CELL HISTIOCYTOSIS IN JAPAN

    A. Morimoto, E. Ishii, S. Ohga, K. Kudou, Y. Ishida, N. Suzuki

    PEDIATRIC BLOOD & CANCER   2009.10

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  • HLH/LCH Committee of the Japanese Society of Pediatric Hematology. Characteristics of Hemophagocytic Lymphohistiocytosis in Neonates: A Nationwide Survey in Japan Reviewed

    Suzuki N, Morimoto A, Ohga S, Kudo K, Ishida Y, Ishii E

    J Pediatr   2009.8

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    DOI: 10.1016/j.jpeds.2009.02.050

  • Neonatal Onset Hemophagocytic Lymphohistiocytosis in a Premature Infant

    Shinji Katsuragi, Shouichi Ohga

    PEDIATRIC BLOOD & CANCER   2009.8

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    DOI: 10.1002/pbc.21963

  • Cardiovascular Complications Associated with Chronic Active Epstein-Barr Virus Infection

    Jun Muneuchi, Shouichi Ohga, Masataka Ishimura, Kazuyuki Ikeda, Kenichiro Yamaguchi, Akihiko Nomura, Hidetoshi Takada, Yasunobu Abe, Toshiro Hara

    PEDIATRIC CARDIOLOGY   2009.4

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    DOI: 10.1007/s00246-008-9343-8

  • RELAPSE OF CHILDREN WITH APLASTIC ANEMIA AFTER IMMUNOSUPPRESSIVE THERAPY

    T. Kamio, E. Ito, A. Ohara, Y. Kosaka, M. Tsuchida, H. Mugishima, H. Yabe, A. Morimoto, S. Ohga, H. Yagasaki, F. Bessho, T. Nakahata, S. Kojima

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   2009.4

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  • DECREASED INCIDENCE OF CLONAL EVOLUTION TO MYELODYSPLASTIC SYNDROME/ACUTE MYELOID LEUKEMIA WITH MONOSOMY 7 IN CHILDREN WITH APLASTIC ANEMIA FOLLOWING REDUCED USE OF G-CSF

    Y. Takahashi, A. Ohara, R. Kobayashi, H. Yabe, M. Tsuchida, H. Mugishima, A. Morimoto, S. Ohga, F. Bessho, N. Yoshida, I. Tsukimoto, T. Nakahata, S. Kojima

    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL   2009.4

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  • Haemophilus influenzae type bによる髄膜炎からショック・DICとなり頭部CTで多発梗塞・出血を認め両下腿の紫斑および足趾壊疽の進行を認めた1例

    石村 匡崇, 吉良 龍太郎, 齋藤 光正, 大賀 正一, 馬場 晴久, 原 寿郎

    脳と発達   2008.7

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  • タクロリムスが奏効したSjoegren症候群関連髄膜脳脊髄炎の1例 髄液サイトカインの変化

    山口 結, 保科 隆之, 大賀 正一, 石村 匡崇, 吉良 龍太郎, 高田 英俊, 原 寿郎

    日本小児科学会雑誌   2008.3

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  • A new scoring system for computed tomography of the chest for assessing the clinical status of bronchopulmonary dysplasia

    Masayuki Ochiai, Shunji Hikino, Hidetake Yabuuchi, Hideki Nakayama, Kazuo Sato, Shouichi Ohga, Toshiro Hara

    JOURNAL OF PEDIATRICS   2008.1

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    DOI: 10.1016/j.jpeds.2007.05.043

  • Sjoegren症候群の経過中に無菌性髄膜炎、急激な感覚障害と膀胱直腸障害を来した1例

    山口 結, 吉良 龍太郎, 鳥巣 浩幸, 石村 匡崇, 大賀 正一, 原 寿郎

    脳と発達   2007.9

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  • 細菌性髄膜炎 Hib髄膜炎に伴う多発脳血栓および電撃性紫斑病から診断されたヘテロ接合体プロテインC欠乏症

    石村 匡崇, 齋藤 光正, 大賀 正一, 吉良 龍太郎, 保科 隆之, 馬場 晴久, 浦田 美秩代, 高田 英俊, 楠原 浩一, 康 東天, 原 寿郎

    2007.9

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  • 細菌性髄膜炎に伴う電撃性紫斑病にProtein C(PC)製剤が著効し診断に至ったヘテロ接合体PC欠乏症

    石村 匡崇, 齋藤 光正, 大賀 正一, 保科 隆之, 馬場 晴久, 吉良 龍太郎, 浦田 美秩代, 高田 英俊, 楠原 浩一, 康 東天, 原 寿郎

    臨床血液   2007.9

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  • 髄膜炎に伴う電撃性紫斑病から診断されたヘテロ接合体プロテインC欠乏症

    石村 匡崇, 齋藤 光正, 大賀 正一, 保科 隆之, 馬場 晴久, 吉良 龍太郎, 浦田 美秩代, 高田 英俊, 楠原 浩一, 康 東天, 原 寿郎

    日本産婦人科・新生児血液学会誌 = The Japanese journal of obstetrical, gynecological & neonatal hematology   2007.6

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  • Successful self-infusion of activated prothrombin complex concentrate for prophylaxis in a child with a factor VIII inhibitor

    Shouichi Ohga, Akihiko Nomura, Hidetoshi Takada, Naohiro Suga, Toshiro Hara

    AMERICAN JOURNAL OF HEMATOLOGY   2007.2

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    DOI: 10.1002/ajh.20751

  • Barium-associated appendicitis in a childhood case with Crohn's disease

    H Nagata, S Ohga, S Hattori, K Masumoto, T Taguchi, T Matsumoto, T Hara

    ACTA PAEDIATRICA   2006.7

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    DOI: 10.1080/08035250600599743

  • Prolonged severe pancytopenia preceding the cutaneous lesions of juvenile xanthogranuloma

    T Hara, S Ohga, S Hattori, M Hatano, N Kaku, A Nomura, H Takada, H Kokuba, K Ohshima, T Hara

    PEDIATRIC BLOOD & CANCER   2006.7

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    DOI: 10.1002/pbc.20514

  • Reduced gene expression of clustered ribosomal proteins in Diamond-Blackfan anemia patients without RPS19 gene mutations

    Y Koga, S Ohga, A Nomura, H Takada, T Hara

    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   2006.6

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    DOI: 10.1097/00043426-200606000-00007

  • A case of chronic recurrent uveitis associated with chronic granulomatous disease

    T Matsuura, KH Sonoda, S Ohga, A Ariyama, T Nakamura, T Ishibashi

    JAPANESE JOURNAL OF OPHTHALMOLOGY   2006.5

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    DOI: 10.1007/s10384-005-0313-x

  • Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection

    T Toubo, S Ohga, H Takada, N Suga, A Nomura, T Ohno, T Hara

    ACTA PAEDIATRICA   2006.5

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    DOI: 10.1080/08035250500371821

  • Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome

    Hidetoshi Takada, Tamami Tanaka, Akihiko Nomura, Shouichi Ohga, Rumiko Shibata, Toshiro Hara

    JOURNAL OF IMMUNOLOGY   2006.4

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  • Maturational alterations of peripheral T cell subsets and cytokine gene expression in 22q11.2 deletion syndrome

    Y Kanaya, S Ohga, K Ikeda, K Furuno, T Ohno, H Takada, N Kinukawa, T Hara

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   2006.4

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    DOI: 10.1111/j.1365-2249.2006.03038.x

  • Epstein-Barr virus-associated bronchial leiomyoma in a boy with cellular immunodeficiency

    M Hatano, H Takada, A Nomura, S Ohga, K Ohshima, Saeki, I, T Tajiri, T Taguchi, S Suita, T Hara

    PEDIATRIC PULMONOLOGY   2006.4

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    DOI: 10.1002/ppul.20375

  • Moyamoya syndrome in a splenectomized patient with β-thalassemia intermedia

    2006.1

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    We describe a 14-year-old Japanese girl with β-thalassemia intermedia who developed moyamoya syndrome after splenectomy. This patient had compound heterozygous mutations of the β-globin gene and received occasional transfusions. After splenectomy at 12 years of age, she transiently required partial exchange transfusions for leukoerythroblastosis but attained transfusion independence. Two years after the splenectomy, transient ischemic attacks occurred repeatedly with right hemiparesis or left paresthesia. Magnetic resonance imaging revealed bilateral stenosis of the internal carotid arteries and dilatation of the perforating branches with the formation of moyamoya vessels but not infarctions. The strict adherence to aspirin and dipyridamole has led to no stroke or progression of the vasculopathy for 8 years. Moyamoya disease has been reported in a patient with β-thalassemia major. Cerebral vasculopathy can be a rare but grave consequence of the thromboembolic complications in β-thalassemia major/intermedia.

    DOI: 10.1177/08830738060210010501

  • A novel CIAS1mutation in a Japanese patient with chronic infantile neurological cutaneous and articular syndrome

    H Takada, K Kusuhara, A Nomura, S Ohga, M Hayashi, M Furue, T Hara

    EUROPEAN JOURNAL OF PEDIATRICS   2005.12

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    DOI: 10.1007/s00431-005-1750-8

  • Insulin-like growth factor II is an autocrine growth factor to prevent apoptosis as well as to enhance proliferation and maturation of erythroid progenitor cells.

    T Nagatomo, K Muta, S Ohga, M Ochiai, S Hikino, T Hara

    BLOOD   2005.11

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  • Successful umbilical cord blood transplantation for severe chronic active Epstein-Barr virus infection after the double failure of hematopoietic stem cell transplantation

    M Ishimura, S Ohga, A Nomura, T Toubo, E Morihana, Y Saito, H Nishio, M Ide, H Takada, T Hara

    AMERICAN JOURNAL OF HEMATOLOGY   2005.11

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    DOI: 10.1002/ajh.20430

  • Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people

    K Yamamoto, E Ishii, H Horiuchi, Ueda, I, S Ohga, M Nishi, Y Ogata, M Zaitsu, A Morimoto, T Hara, S Imashuku, T Sasazuki, M Yasukawa

    JOURNAL OF HUMAN GENETICS   2005.11

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    DOI: 10.1007/s10038-005-0293-1

  • Bronchiolitis obliterans organizing pneumonia as an initial manifestation in systemic lupus erythematosus

    H Takada, Y Saito, A Nomura, S Ohga, K Kuwano, N Nakashima, S Aishima, N Tsuru, T Hara

    PEDIATRIC PULMONOLOGY   2005.9

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    DOI: 10.1002/ppul.20224

  • Proposed guidelines for diagnosing chronic active Epstein-Barr virus infection

    M Okano, K Kawa, H Kimura, A Yachie, H Wakiguchi, A Maeda, S Imai, S Ohga, H Kanegane, S Tsuchiya, T Morio, M Mori, S Yokota, S Imashuku

    AMERICAN JOURNAL OF HEMATOLOGY   2005.9

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    DOI: 10.1002/ajh.20398

  • Insulin-like growth factor II is an autocrine growth factor to prevent apoptosis as well as to enhance proliferation and maturation of erythroid progenitor cells in cord blood

    T Nagatomo, K Muta, S Ohga, M Ochiai, S Hikino, T Hara

    EXPERIMENTAL HEMATOLOGY   2005.7

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  • Distinct gene expression patterns of peripheral blood cells in hyper-IgE syndrome

    T Tanaka, H Takada, A Nomura, S Ohga, R Shibata, T Hara

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   2005.6

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    DOI: 10.1111/j.1365-2249.2005.02805.x

  • Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions.

    Eiichi Ishii, Ikuyo Ueda, Ryutaro Shirakawa, Ken Yamamoto, Hisanori Horiuchi, Shouichi Ohga, Kenji Furuno, Akira Morimoto, Miyoko Imayoshi, Yoshiyasu Ogata, Masafumi Zaitsu, Masahiro Sako, Kenichi Koike, Akifumi Sakata, Hidetoshi Takada, Toshiro Hara, Shinsaku Imashuku, Takehiko Sasazuki, Masaki Yasukawa

    Blood   2005.5

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    DOI: 10.1182/blood-2004-08-3296

  • Review of hemophagocytic lymphohistiocytosis (HLH) in children with focus on Japanese experiences

    E Ishii, S Ohga, S Imashuku, N Kimura, Ueda, I, A Morimoto, K Yamamoto, M Yasukawa

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY   2005.3

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    DOI: 10.1016/j.critrevonc.2004.11.002

  • T-Cell-depleted CD34+ cell transplantation from an HLA-mismatched donor in a low-birthweight infant with X-linked severe combined immunodeficiency

    A Nomura, H Takada, S Ohga, N Ishii, T Inoue, T Hara

    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   2005.2

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    DOI: 10.1097/01.mph.0000152859.59880.54

  • Blackfan-Diamond症候群の病態と治療

    大賀正一、古賀友紀、原寿郎

    Annual Review 血液2005   2004.12

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  • Successful unrelated cord blood transplantation for Epstein-Barr virus-associated lymphoproliferative disease with hemophagocytic syndrome

    T Toubo, N Suga, S Ohga, A Nomura, Y Onoe, H Takada, T Hara

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2004.12

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    DOI: 10.1532/IJH97.04081

  • Classification of familial hemophagocytic lymphohistiocytosis based on genetic and immunologic analyses.

    E Ishii, Ueda, I, K Yamamoto, S Ohga, K Furuno, A Morimoto, M Imayoshi, M Sako, H Takada, T Hara, S Imashuku, T Sasazuki, M Yasukawa

    BLOOD   2004.11

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  • Prospective multicenter trial comparing repeated immunosuppressive therapy (IST) with stem cell transplantation (SCT) from an alternative donor as a second-line treatment for children with acquired aplastic anemia (AA).

    R Kobayashi, H Ayukawa, K Kato, T Kaneko, H Kigasawa, H Yabe, M Tsuchida, H Mugishima, A Ohara, A Morimoto, M Yamamoto, S Ohga, F Bessho, T Nakahata, L Tsukimoto, S Kojima

    BLOOD   2004.11

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  • Dominant expression of interleukin-10 and transforming growth factor-beta genes in activated T-cells of chronic active Epstein-Barr virus infection

    S Ohga, A Nomura, H Takada, T Tanaka, K Furuno, Y Takahata, N Kinukawa, N Fukushima, S Imai, T Hara

    JOURNAL OF MEDICAL VIROLOGY   2004.11

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    DOI: 10.1002/jmv.20197

  • Identification of novel MUNC13-4 mutations in familial haemophagocytic lymphohistiocytosis and functional analysis of MUNC13-4-deficient cytotoxic T lymphocytes

    K Yamamoto, E Ishii, M Sako, S Ohga, K Furuno, N Suzuki, Ueda, I, M Imayoshi, S Yamamoto, A Morimoto, H Takada, T Hara, S Imashuku, T Sasazuki, M Yasukawa

    JOURNAL OF MEDICAL GENETICS   2004.10

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    DOI: 10.1136/jmg.2004.021121

  • Microarray analysis of human milk cells: persistent high expression of osteopontin during the lactation period

    T Nagatomo, S Ohga, H Takada, A Nomura, S Hikino, M Imura, K Ohshima, T Hara

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   2004.10

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    DOI: 10.1111/j.1365-2249.2004.02549.x

  • Impaired host defense against Sporothrix schenckii in mice with chronic granulomatous disease

    Hideko Kajiwara, Mitsumasa Saito, Shouichi Ohga, Takeshi Uenotsuchi, Shin-Ichi Yoshida

    Infection and Immunity   2004.9

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    DOI: 10.1128/IAI.72.9.5073-5079.2004

  • Increased IL-16 levels in hemophagocytic lymphohistiocytosis

    Hidetoshi Takada, Shouichi Ohga, Yumi Mizuno, Akihiko Nomura, Toshiro Hara

    Journal of Pediatric Hematology/Oncology   2004.9

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    DOI: 10.1097/01.mph.0000134465.86671.2e

  • CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene.

    Yasushi Takahata, Akihiko Nomura, Hidetoshi Takada, Shouichi Ohga, Kenji Furuno, Shunji Hikino, Hideki Nakayama, Shimon Sakaguchi, Toshiro Hara

    Experimental hematology   2004.7

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  • Increased serum levels of interferon-gamma-inducible protein 10 and monokine induced by gamma interferon in patients with haemophagocytic lymphohistiocytosis

    H Takada, Y Takahata, A Nomura, S Ohga, Y Mizuno, T Hara

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   2003.9

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  • Quantification of circulating varicella zoster virus-DNA for the early diagnosis of visceral varicella

    Y Ishizaki, J Tezuka, S Ohga, A Nomura, N Suga, R Kuromaru, K Kusuhara, Y Mizuno, N Kasuga, T Hara

    JOURNAL OF INFECTION   2003.8

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    DOI: 10.1016/S0163-4453(03)00004-5

  • Lymphoproliferative Disease in Childhood: Clinical and biological role of cytokines

    Ohga S, Takada H, Nomura A, Hara T

    2003.1

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  • Immunological aspects of Epstein-Barr virus infection

    S Ohga, A Nomura, H Takada, T Hara

    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY   2002.12

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  • Immunological aspects of Epstein-Barr virus infection

    Shouichi Ohga, Akihiko Nomura, Hidetoshi Takada, Toshiro Hara

    Critical Reviews in Oncology/Hematology   2002.12

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    DOI: 10.1016/S1040-8428(02)00112-9

  • CD4(-)CD8(-) T-cell polymyositis in a patient with chronic active Epstein-Barr virus infection

    S Tsutsumi, S Ohga, A Nomura, H Takada, S Sakai, K Ohshima, K Sumimoto, T Hara

    AMERICAN JOURNAL OF HEMATOLOGY   2002.11

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    DOI: 10.1002/ajh.10207

  • Participation in clinical trials is a favorable prognostic factor for children with aplastic anemia

    S Kojima, A Ohara, R Kobayashi, S Nishimura, K Sugita, M Maeda, M Sako, S Hibi, K Fujisawa, S Ohga, Y Toyoda, H Mugishima, T Nakahata, Tsukimoto, I, K Yamamoto

    BLOOD   2002.11

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  • Treatment responses of childhood aplastic anaemia with chromosomal aberrations at diagnosis

    S Ohga, A Ohara, S Hibi, S Kojima, F Bessho, S Tsuchiya, Y Ohshima, N Yoshida, Y Kashii, S Nishimura, K Kawakami, K Nishikawa

    BRITISH JOURNAL OF HAEMATOLOGY   2002.7

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    DOI: 10.1046/j.1365-2141.2002.03582.x

  • Optic disk vasculitis associated with chronic active Epstein-Barr virus infection

    M Yamamoto, S Ohga, Y Ohnishi, H Inomata

    OPHTHALMOLOGICA   2002.5

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  • Epstein-Barr virus associated diseases in childhood.-Immunological aspects of Epstein-Barr virus infection

    Ohga S, Nomura A, Takada H, Hara T

    2002.1

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  • Expansion of trisomy 8 and Sweet syndrome in a prolonged course of aplastic anemia

    S Ohga, A Nomura, H Takada, H Terao, N Harada, T Hara

    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   2002.1

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    DOI: 10.1097/00043426-200201000-00017

  • Functional analyses of cord blood natural killer cells and T cells: a distinctive interleukin-18 response

    A Nomura, H Takada, CH Jin, T Tanaka, S Ohga, T Hara

    EXPERIMENTAL HEMATOLOGY   2001.10

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    DOI: 10.1016/S0301-472X(01)00689-0

  • Moyamoya syndrome with spherocytosis: Effect of splenectomy on strokes

    Y Tokunaga, S Ohga, S Suita, T Matsushima, T Hara

    PEDIATRIC NEUROLOGY   2001.7

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    DOI: 10.1016/S0887-8994(01)00283-1

  • Interleukin-18 in hemophagocytic lymphohistiocytosis

    H Takada, A Nomura, S Ohga, T Hara

    LEUKEMIA & LYMPHOMA   2001.6

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  • Inflammatory bowel disease-like colitis in glycogen storage disease type lb

    T Yamaguchi, K Ihara, T Matsumoto, Y Tsutsumi, A Nomura, S Ohga, T Hara

    INFLAMMATORY BOWEL DISEASES   2001.5

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  • Quantitative monitoring of circulating Epstein-Barr virus DNA for predicting the development of posttransplantation lymphoproliferative disease

    S Ohga, E Kubo, A Nomura, H Takada, N Suga, E Ishii, A Suminoe, T Inamitsu, A Matsuzaki, N Kasuga, T Hara

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2001.4

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  • Epstein-Barr virus (EBV) load and cytokine gene expression in activated T cells of chronic active EBV infection

    S Ohga, A Nomura, H Takada, K Ihara, K Kawakami, F Yanai, Y Takahata, T Tanaka, N Kasuga, T Hara

    JOURNAL OF INFECTIOUS DISEASES   2001.1

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  • Inflammatory bowel disease-like complication in anhidrotic ectodermal dysplasia

    S Ohga, A Ryu, T Nagatomo, H Takada, K Ihara, K Kawamoto, T Kai, T Hara

    AMERICAN JOURNAL OF GASTROENTEROLOGY   2000.12

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    DOI: 10.1016/S0002-9270(00)02187-0

  • Epstein-Barr virus (EBV) and cytokine gene expressions in activated T-cells of chronic active EBV infection.

    S Ohga, A Nomura, H Takada, K Ihara, K Kawakami, F Yanai, N Kasuga, T Hara

    BLOOD   2000.11

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  • MR choroid plexus sign of iron overload

    R Kira, S Ohga, H Takada, K Gondo, F Mihara, T Hara

    NEUROLOGY   2000.11

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  • Neuron-specific enolase in hemophagocytic lymphohistiocytosis: A potential indicator for macrophage activation?

    K Honda, S Ohga, H Takada, A Nomura, K Ohshima, N Kinukawa, Y Mizuno, T Hara

    INTERNATIONAL JOURNAL OF HEMATOLOGY   2000.7

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  • IL-18 response of cord blood T and NK cells.

    A Nomura, H Takada, C Jin, S Ohga, T Hara

    FASEB JOURNAL   2000.4

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  • Thymus-independent expansion of T lymphocytes in children after allogeneic bone marrow transplantation

    K Honda, H Takada, Y Nagatoshi, K Akazawa, S Ohga, E Ishii, J Okamura, T Hara

    BONE MARROW TRANSPLANTATION   2000.3

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  • Epstein-Barr virus-associated lymphoproliferative disease after a cord blood transplant for Diamond-Blackfan anemia

    S Ohga, Y Kanaya, H Maki, H Takada, K Ohshima, M Kanda, A Nomura, A Suminoe, A Matsuzaki, T Hara

    BONE MARROW TRANSPLANTATION   2000.1

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  • Neurotrophin-3 levels in cerebrospinal fluid from children with bacterial meningitis, viral meningitis, or encephalitis

    Y Mizuno, H Takada, K Urakami, K Ihara, R Kira, A Suminoe, S Ohga, T Aoki, T Hara

    JOURNAL OF CHILD NEUROLOGY   2000.1

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  • Changes in the cause of death in pediatric acquired aplastic anemia in Japan: Comparison of 425 patients registered during '88-'95 and 118 patients registered during '65-'75.

    A Ohara, S Kojima, F Bessho, S Konishi, M Tsuchida, S Ohga, Y Toyoda, K Koike, R Hanada, S Imashuku, T Nakahata, Tsukimoto, I

    BLOOD   1999.11

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  • WASP is involved in proliferation and differentiation of human haemopoietic progenitors in vitro

    M Kajiwara, S Nonoyama, M Eguchi, T Morio, K Imai, H Okawa, M Kaneko, M Sako, S Ohga, M Maeda, S Hibi, H Hashimito, A Shibuya, HD Ochs, T Nakahata, JI Yata

    BRITISH JOURNAL OF HAEMATOLOGY   1999.11

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    DOI: 10.1046/j.1365-2141.1999.01694.x

  • Trisomy 10 in a child with acute nonlymphocytic leukemia followed by relapse with a different clone

    Y Sakai, H Nakayama, A Matsuzaki, Y Nagatoshi, A Suminoe, K Honda, T Inamitsu, S Ohga, T Hara

    CANCER GENETICS AND CYTOGENETICS   1999.11

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    DOI: 10.1016/S0165-4608(99)00087-4

  • Streptococcus intermedius-brain abscess in chronic granulomatous disease

    T Nagatomo, S Ohga, M Saito, H Takada, Y Sasaki, K Okada, T Inamura, T Hara

    EUROPEAN JOURNAL OF PEDIATRICS   1999.10

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    DOI: 10.1007/s004310051231

  • Cerebrospinal fluid cytokine levels and dexamethasone therapy in bacterial meningitis

    S Ohga, K Okada, K Ueda, H Takada, M Ohta, T Aoki, N Kinukawa, S Miyazaki, T Hara

    JOURNAL OF INFECTION   1999.7

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    DOI: 10.1016/S0163-4453(99)90103-2

  • Restricted diversification of T-cells in chronic active Epstein-Barr virus infection: Potential inclination to T-lymphoproliferative disease

    S Ohga, N Kimura, H Takada, M Nagano, K Ohshima, A Nomura, K Muraoka, H Take, S Yamamori, T Hara

    AMERICAN JOURNAL OF HEMATOLOGY   1999.5

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  • Increased interleukin-18 levels in patients with hemophagocytic lymphohistiocytosis.

    H Takada, S Ohga, K Honda, M Ikeda, M Kurimoto, T Hara

    FASEB JOURNAL   1999.3

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  • CD95 (Fas) ligand expression of Epstein-Barr virus (EBV)-infected lymphocytes: A possible mechanism of immune evasion in chronic active EBV infection

    K Ohshima, J Suzumiya, M Sugihara, S Nagafuchi, S Ohga, M Kikuchi

    PATHOLOGY INTERNATIONAL   1999.1

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    DOI: 10.1046/j.1440-1827.1999.00816.x

  • Central nervous system T-cell lymphoproliferative disorder in a patient with chronic active Epstein-Barr virus infection

    S Ohga, H Takada, K Honda, T Inamura, K Gondo, K Ohshima, M Yamamoto, T Hara

    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   1999.1

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    DOI: 10.1097/00043426-199901000-00011

  • Clinicopathological study of severe chronic active Epstein-Barr virus infection that developed in association with lymphoproliferative disorder and/or hemophagocytic syndrome

    K Ohshima, J Suzumiya, M Sugihara, S Nagafuchi, S Ohga, M Kikuchi

    PATHOLOGY INTERNATIONAL   1998.12

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    DOI: 10.1111/j.1440-1827.1998.tb03864.x

  • Development of MDS/AML in children with hepatitis associated aplastic anemia following treatment with ALG, cyclosporine and rhG-CSF.

    A Ohara, S Kojima, S Hibi, H Inada, H Kigasawa, J Okamura, S Ohga, Y Toyoda, F Bessho, K Koike, S Konishi, M Tsuchida, R Hanada, S Imashuku, T Nakahata, Tsukimoto, I

    BLOOD   1998.11

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  • Interferon-alpha therapy for chronic myelogenous leukemia during pregnancy

    M Kuroiwa, H Gondo, K Ashida, T Kamimura, T Miyamoto, Y Niho, K Tsukimori, H Nakano, S Ohga

    AMERICAN JOURNAL OF HEMATOLOGY   1998.9

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  • Interferon-alpha therapy for chronic active Epstein-Barr virus infection: Potential effect on the development of T-lymphoproliferative disease

    Y Sakai, S Ohga, Y Tonegawa, H Takada, F Nakao, H Nakayama, T Aoki, S Yamamori, T Hara

    JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   1998.7

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    DOI: 10.1097/00043426-199807000-00013

  • Clinical and epidemiologic studies of familial hemophagocytic lymphohistiocytosis in Japan

    E Ishii, S Ohga, M Tanimura, S Imashuku, M Sako, S Mizutani, S Miyazaki

    MEDICAL AND PEDIATRIC ONCOLOGY   1998.5

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  • Cerebrospinal fluid cytokine concentrations in a patient with lupus meningoencephalitis: Differences from cytokine profiles in central nervous system infections

    S Ohga, K Gondo, A Nomura, Y Onoe, A Matsuzaki, T Hara

    BRITISH JOURNAL OF RHEUMATOLOGY   1998.1

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  • Hypogammaglobulinaemia in a patient with ring chromosome 21

    S Ohga, F Nakao, O Narazaki, N Fusazaki, T Aoki, K Kamesaki, T Hara

    ARCHIVES OF DISEASE IN CHILDHOOD   1997.9

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  • Integrated Epstein-Barr virus (EBV) and chromosomal abnormality in chronic active EBV infection

    K Ohshima, J Suzumiya, S Ohga, A Ohgami, M Kikuchi

    INTERNATIONAL JOURNAL OF CANCER   1997.6

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  • Intrapulmonary Mycobacterium avium infection as the first manifestation of chronic granulomatous disease

    S Ohga, K Ikeuchi, R Kadoya, K Okada, C Miyazaki, S Suita, K Ueda

    JOURNAL OF INFECTION   1997.3

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  • Idiopathic pulmonary hemosiderosis: current diagnosis and management

    Ohga S, Miyazaki S

    1997.1

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  • What are the essential symptoms in the Hoyeraal-Hreidarsson syndrome?

    S Ohga, T Kai, K Honda, H Nakayama, T Inamitsu, K Ueda

    EUROPEAN JOURNAL OF PEDIATRICS   1997.1

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  • Molecular analysis of glucose phosphate isomerase deficiency associated with hereditary hemolytic anemia

    H Kanno, H Fujii, A Hirono, Y Ishida, S Ohga, Y Fukumoto, K Matsuzawa, S Ogawa, S Miwa

    BLOOD   1996.9

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  • Granulocyte transfusion: Stimulation of low dose granulocyte colony-stimulating factor in donors for leukapheresis

    A Nomura, S Ohga, A Matsuzaki, T Kai, S Inaba, M Suda, K Ueda

    ACTA PAEDIATRICA JAPONICA   1996.8

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  • Chronic myelomonocytic leukaemia with t(8;9)(p11;q34) in childhood: An example of the 8p11 myeloproliferative disorder?

    H Nakayama, T Inamitsu, S Ohga, T Kai, M Suda, A Matsuzaki, K Ueda

    BRITISH JOURNAL OF HAEMATOLOGY   1996.3

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  • 慢性活動性EBウイルス感染症における最近の知見

    大賀正一、宮崎澄雄

    Annual Review 血液1996   1995.12

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  • IDIOPATHIC PULMONARY HEMOSIDEROSIS IN JAPAN - 39 POSSIBLE CASES FROM A SURVEY QUESTIONNAIRE

    S OHGA, K TAKAHASHI, S MIYAZAKI, H KATO, K UEDA

    EUROPEAN JOURNAL OF PEDIATRICS   1995.12

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  • AN ABNORMAL FIBRINOGEN FUKUOKA-II (GLY-B-BETA-15-]CYS) CHARACTERIZED BY DEFECTIVE FIBRIN LATERAL ASSOCIATION AND MIXED DISULFIDE FORMATION

    T KAMURA, H TSUDA, Y YAE, S HATTORI, S OHGA, Y SHIBATA, SI KAWABATA, N HAMASAKI

    JOURNAL OF BIOLOGICAL CHEMISTRY   1995.12

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    DOI: 10.1074/jbc.270.49.29392

  • TREATMENT OF YOUNG RELAPSED HODGKINS-DISEASE PATIENTS WITH HIGH-DOSE CHEMOTHERAPY FOLLOWED BY PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION

    A MATSUZAKI, J OKAMURA, Y NAGATOSHI, T KAI, S OHGA, H GONDO, S INABA, K UEDA

    LEUKEMIA & LYMPHOMA   1995.8

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  • HISTIOCYTIC HEMOPHAGOCYTOSIS IN A PATIENT WITH KAWASAKI-DISEASE - CHANGES IN THE HYPERCYTOKINAEMIC STATE

    S OHGA, A OOSHIMA, J FUKUSHIGE, K UEDA

    EUROPEAN JOURNAL OF PEDIATRICS   1995.7

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  • HEMATOLOGIC RECOVERY AFTER MARROW-ABLATIVE CHEMOTHERAPY AND PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION IN CHILDREN

    A MATSUZAKI, T KAI, S OHGA, A NOMURA, S INABA, M HARADA, E ISHII, K UEDA

    PEDIATRIC HEMATOLOGY AND ONCOLOGY   1995.3

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    DOI: 10.3109/08880019509029556

  • HAPTOGLOBIN THERAPY FOR ACUTE FAVISM - A JAPANESE BOY WITH GLUCOSE-6-PHOSPHATE-DEHYDROGENASE GUADALAJARA

    S OHGA, E HIGASHI, A NOMURA, A MATSUZAKI, A HIRONO, S MIWA, H FUJII, K UEDA

    BRITISH JOURNAL OF HAEMATOLOGY   1995.2

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  • LIPOSTEROID AGAINST REFRACTORY PULMONARY HEMORRHAGE IN IDIOPATHIC PULMONARY HEMOSIDEROSIS

    S OHGA, A NOMURA, N SUGA, S HIKINO, R KIRA, A MATSUZAKI, K MASUDA, K UEDA

    EUROPEAN JOURNAL OF PEDIATRICS   1994.9

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  • SERUM ERYTHROPOIETIN LEVELS IN TERM AND PRETERM INFANTS DURING THE 1ST YEAR OF LIFE

    H YAMASHITA, J KUKITA, S OHGA, H NAKAYAMA, K AKAZAWA, K UEDA

    AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   1994.8

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  • ACUTE PROMYELOCYTIC LEUKEMIA IN A PATIENT TREATED WITH ETOPOSIDE FOR LANGERHANS CELL HISTIOCYTOSIS

    A MATSUZAKI, T INAMITSU, T WATANABE, S OHGA, E ISHII, Y NAGOTOSHI, H TASAKA, M SUDA, K UEDA

    BRITISH JOURNAL OF HAEMATOLOGY   1994.4

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  • ASSOCIATION BETWEEN FEVER AND SERUM INTERLEUKIN-6 LEVELS IN CHILDREN WITH GROUP-A BETA-HEMOLYTIC STREPTOCOCCAL INFECTION

    S OHGA, M NISHIZAKI, T NAGASHIMA, K UEDA

    JOURNAL OF THERMAL BIOLOGY   1994.4

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  • HOMOLOGOUS DINUCLEOTIDE (GT OR TG) DELETION IN JAPANESE PATIENTS WITH CHRONIC GRANULOMATOUS-DISEASE WITH P47-PHOX DEFICIENCY

    M IWATA, H NUNOI, H YAMAZAKI, T NAKANO, H NIWA, S TSURUTA, S OHGA, S OHMI, S KANEGASAKI, MATSUDA, I

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   1994.3

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    DOI: 10.1006/bbrc.1994.1382

  • CEREBROSPINAL-FLUID CONCENTRATIONS OF INTERLEUKIN-1-BETA, TUMOR-NECROSIS-FACTOR-ALPHA, AND INTERFERON-GAMMA IN BACTERIAL-MENINGITIS

    S OHGA, T AOKI, K OKADA, H AKEDA, K FUJIOKA, A OHSHIMA, T MORI, MINAMISHIMA, I, K UEDA

    ARCHIVES OF DISEASE IN CHILDHOOD   1994.2

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  • INFLAMMATORY CYTOKINES IN VIRUS-ASSOCIATED HEMOPHAGOCYTIC SYNDROME - INTERFERON-GAMMA AS A SENSITIVE INDICATOR OF DISEASE-ACTIVITY

    S OHGA, A MATSUZAKI, M NISHIZAKI, T NAGASHIMA, T KAI, M SUDA, K UEDA

    AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   1993.8

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  • DISSEMINATED INTRAVASCULAR COAGULATION IN A PATIENT WITH HEMOPHILIA-B DURING FACTOR-IX REPLACEMENT THERAPY

    S OHGA, M SAITO, A MATSUKAZI, T KAI, K UEDA

    BRITISH JOURNAL OF HAEMATOLOGY   1993.6

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  • SERUM INTERLEUKIN-6 AND FEVER AT DIAGNOSIS IN CHILDREN WITH ACUTE-LEUKEMIA

    MINAMISHIMA, I, S OHGA, E ISHII, A MATSUZAKI, T KAI, K AKAZAWA, K UEDA

    AMERICAN JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY   1993.5

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  • GRANULOCYTE COLONY-STIMULATING FACTOR AND PLATELET-AGGREGATION

    K SHIMODA, S OKAMURA, S INABA, T OKAMURA, S OHGA, K UEDA, Y NIHO

    LANCET   1993.3

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  • THE INFLAMMATORY CYTOKINES IN MEASLES - CORRELATION BETWEEN SERUM INTERFERON-GAMMA LEVELS AND LYMPHOCYTE SUBPOPULATIONS

    S OHGA, C MIYAZAKI, K OKADA, K AKAZAWA, K UEDA

    EUROPEAN JOURNAL OF PEDIATRICS   1992.7

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  • A PROTECTIVE ROLE OF GAMMA-DELTA T-CELLS IN PRIMARY INFECTION WITH LISTERIA-MONOCYTOGENES IN MICE

    K HIROMATSU, Y YOSHIKAI, G MATSUZAKI, S OHGA, K MURAMORI, K MATSUMOTO, JA BLUESTONE, K NOMOTO

    JOURNAL OF EXPERIMENTAL MEDICINE   1992.1

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  • ASEPTIC-MENINGITIS IN CHILDREN - CORRELATION BETWEEN FEVER AND INTERFERON-GAMMA LEVEL

    MINAMISHIMA, I, S OHGA, E ISHII, C MIYAZAKI, K HAMADA, K AKAZAWA, K UEDA

    EUROPEAN JOURNAL OF PEDIATRICS   1991.8

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  • KINETICS OF FEVER AND ITS RELATED CYTOKINES IN MICE AFTER INTRAPERITONEAL INFECTION WITH LISTERIA-MONOCYTOGENES

    S OHGA, K UEDA, Y YOSHIKAI, Y TAKEDA, K HIROMATSU, K NOMOTO

    JOURNAL OF THERMAL BIOLOGY   1991.3

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  • DELETION OF SELF-REACTIVE T-CELLS IN THE DONOR-DERIVED T-CELLS BUT NOT IN THE HOST-DERIVED T-CELLS IN FULLY ALLOGENEIC RADIATION CHIMERAS - MLS-REACTIVE T-CELLS IN ALLOGENEIC RADIATION CHIMERAS

    M OGIMOTO, Y YOSHIKAI, G MATSUZAKI, S OHGA, K MATSUMOTO, K NOMOTO

    THYMUS   1991.2

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  • SERUM INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR ACTIVITIES IN FEBRILE CHILDREN WITH ACUTE-LEUKEMIA

    E ISHII, S OHGA, K UEDA, K AKAZAWA

    INTERNATIONAL JOURNAL OF HEMATOLOGY   1991.2

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  • TcRV領域遺伝子の選択とMHC

    大賀正一、吉開泰信

    Annual Review 免疫1991   1990.12

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  • DIFFERENT EXPRESSION OF T-CELL RECEPTOR BETA-CHAIN VARIABLE REGION GENES IN LYMPH-NODES OF LPR MICE WITH DIFFERENT ALLELES OF THE MAJOR HISTOCOMPATIBILITY COMPLEX

    S OHGA, Y YOSHIKAI, K KISHIHARA, G MATSUZAKI, M OGIMOTO, K NOMOTO

    IMMUNOLOGY   1990.6

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  • CLONAL DELETION OF SELF-MLS-REACTIVE THYMOCYTES AT THE EARLY STAGE IN H-2-COMPATIBLE BUT MLS-DISPARATE RADIATION CHIMERAS

    M OGIMOTO, Y YOSHIKAI, G MATSUZAKI, S OHGA, K MATSUMOTO, K NOMOTO

    IMMUNOLOGY   1990.3

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  • SEQUENTIAL APPEARANCE OF GAMMA DELTA-BEARING AND ALPHA BETA-BEARING T-CELLS IN THE PERITONEAL-CAVITY DURING AN IP INFECTION WITH LISTERIA-MONOCYTOGENES

    S OHGA, Y YOSHIKAI, Y TAKEDA, K HIROMATSU, K NOMOTO

    EUROPEAN JOURNAL OF IMMUNOLOGY   1990.3

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    Language:English  

    DOI: 10.1002/eji.1830200311

  • EFFECTS OF STIMULATED OR IMMUNOLOGICALLY ACTIVATED MACROPHAGES ON THE INDUCTION OF IMMUNE-RESPONSES TO LISTERIA-MONOCYTOGENES

    Y YOSHIKAI, S OHGA, Y TAKEDA, K NOMOTO

    IMMUNOBIOLOGY   1990.2

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    Language:English  

  • HUMAN GAMMA-DELTA-T-CELL RECEPTOR-POSITIVE CELL-MEDIATED INHIBITION OF ERYTHROPOIESIS INVITRO IN A PATIENT WITH TYPE-1 AUTOIMMUNE POLYGLANDULAR SYNDROME AND PURE RED-BLOOD-CELL APLASIA

    T HARA, Y MIZUNO, M NAGATA, Y OKABE, S TANIGUCHI, M HARADA, Y NIHO, K OSHIMI, S OHGA, Y YOSHIKAI, K NOMOTO, K YUMURA, K KAWAHA, K UEDA

    BLOOD   1990.2

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    Language:English  

  • ABNORMAL REARRANGEMENTS OF T-CELL RECEPTOR GENES OCCUR IN LONG-TERM CULTURED BONE-MARROW CELLS OF LPR/LPR MICE

    S OHGA, Y YOSHIKAI, K MATSUMOTO, K KISHIHARA, G MATSUZAKI, K NOMOTO

    IMMUNOLOGY   1989.8

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    Language:English  

  • EXPRESSION AND SEQUENCES OF T-CELL RECEPTOR BETA-CHAIN VARIABLE GENES IN THE ENLARGED LYMPH-NODES OF C57BL/6-1PR/1PR MICE

    S OHGA, Y YOSHIKAI, K KISHIHARA, G MATSUZAKI, T ASANO, K NOMOTO

    CLINICAL AND EXPERIMENTAL IMMUNOLOGY   1989.7

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    Language:English  

  • REARRANGEMENTS OF T-CELL ANTIGEN RECEPTOR-GAMMA AND RECEPTOR-DELTA CHAIN GENES ARE DETECTED IN THE LONG-TERM CULTURED BONE-MARROW CELLS OF ATHYMIC NUDE-MICE BUT NOT IN THOSE OF EUTHYMIC MICE

    Y YOSHIKAI, Y TAKEDA, S OHGA, K KISHIHARA, G MATSUZAKI, K NOMOTO

    IMMUNOLOGY   1989.4

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    Language:English  

  • FUNCTIONAL T-CELL RECEPTOR DELTA-CHAIN GENE MESSAGES IN ATHYMIC NUDE-MICE

    Y YOSHIKAI, G MATSUZAKI, Y TAKEDA, S OHGA, K KISHIHARA, H YUUKI, K NOMOTO

    EUROPEAN JOURNAL OF IMMUNOLOGY   1988.7

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    Language:English  

    DOI: 10.1002/eji.1830180711

  • INVERSION OF CHROMOSOME-16 WITH ABNORMAL MARROW EOSINOPHILS IN ACUTE MYELOMONOCYTIC LEUKEMIA - A CASE-REPORT OF A 9-MONTH-OLD INFANT

    S OHGA, E ISHII, K FUJIOKA, K UEDA

    ACTA HAEMATOLOGICA JAPONICA   1987.2

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    Language:English  

  • FAMILIAL ERYTHROPHAGOCYTIC LYMPHOHISTIOCYTOSIS - SURFACE MARKER ANALYSIS USING MONOCLONAL-ANTIBODIES

    E ISHII, T HARA, S OHGA, K UEDA, M SUDA, J NAKAMURA, T YANAGI, Y TSUJI

    EUROPEAN JOURNAL OF HAEMATOLOGY   1987.1

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    Language:English  

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Professional Memberships

  • Japanese Society for Pediatric Infectoius Diseases

  • The Japan Society of Obstetrical, Gynecological and Neonatal Hematology

  • Japanese Society for Immunology

  • The Japan Society for Hematopoietic Cell Transplantation

  • The Japan Society for Clinical Immunology

  • Japan Pediatric Society

  • The Japanese Society of Hematology

  • The Japanese Society of Pediatric Hematology

  • Histiocyte Society

  • Japan Society of Perinatal and Neonatal Medicine

  • The Japanese Society on Thrombosis and Hemostasis

  • The Japan Society of Obstetrical,Gynecological & Neonatal Hematology

  • The Japanese Sciety of Pediatric Hematology / Oncology

  • The Japanese Society of Child Health

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Committee Memberships

  • Vice-chairman   Domestic

    2022.5 - 2024.4   

  • Executive head   Domestic

    2021.6 - Present   

  • 九州山口小児血液・免疫・腫瘍研究会   代表世話人   Domestic

    2021.4 - 2025.3   

  • Executive head   Domestic

    2020.6 - Present   

  • EBウイルス感染症研究会   代表世話人   Domestic

    2019.7 - Present   

  • 日本血液学会   代議員   Domestic

    2017.7 - 2018.3   

  • Organizer   Domestic

    2017.7   

  • Councilor   Domestic

    2017.7   

  • Executive   Domestic

    2017.7   

  • Councilor   Domestic

    2017.7   

  • Executive   Domestic

    2017.7   

  • Councilor   Domestic

    2017.7   

  • Councilor   Domestic

    2017.4 - 2018.3   

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Academic Activities

  • 会頭 International contribution

    第127回日本小児科学会学術集会  ( ヒルトン福岡シーホーク ) 2024.4

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    Type:Competition, symposium, etc. 

    Number of participants:8,000

  • 座長(Chairmanship)

    第45回日本血栓止血学会学術集会  ( 福岡県北九州市 ) 2023.6

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第33回日本産婦人科・新生児血液学会 学術集会  ( 埼玉県さいたま市 ) 2023.6

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    Type:Competition, symposium, etc. 

  • 会長

    第30回日本産婦人科・新生児血液学会  2020.12

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    Type:Competition, symposium, etc. 

  • 会長

    第50回 日本小児感染症学会総会・学術集会  ( 福岡 ) 2018.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第92回日本感染症学会学術講演会  ( 岡山 ) 2018.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第6回九州SCT研究会  ( 福岡 ) 2018.3

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    Type:Competition, symposium, etc. 

  • 座長(Chaimanship)

    福岡小児自己免疫疾患フォーラム  ( 福岡 ) 2018.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    九州止血治療懇話会 2017  ( 福岡 ) 2017.12

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第59回日本小児血液・がん学会学術集会  ( 愛媛 ) 2017.11

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第8回BCRF報告会  ( 東京 ) 2017.3

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第58回日本小児血液・がん学会学術集会  ( 東京 ) 2016.12

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    Type:Competition, symposium, etc. 

  • 科学研究費委員会専門委員

    Role(s): Review, evaluation

    独立行政法人日本学術振興会  2016.12

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    Type:Scientific advice/Review 

  • 座長(Chairmanship)

    第26回日本産婦人科・新生児血液学会学術集会  ( 長崎 ) 2016.7 - 2016.2

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第23回博多シンポジウム「検査血液学の展開と病態解析の役割」  ( 福岡 ) 2010.11 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第17回小児再生不良性貧血治療研究会・第15回小児MDS治療研究会  ( 名古屋 ) 2010.5 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第17回小児再生不良性貧血治療研究会  ( 名古屋 ) 2010.5 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第20回EBウイルス感染症研究会  ( 東京 ) 2010.3 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回EBウイルス感染症研究会  ( 東京 ) 2010.3 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第6回血球貪食症候群研究会  ( 東京 ) 2010.3 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第16回小児再生不良性貧血治療研究会  ( 名古屋 ) 2009.5 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第50回日本小児血液学会(ポスター/ランチョンセミナー)  ( 幕張 ) 2008.11 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第9回九州血友病治療懇話会 特別講演  ( 福岡 ) 2008.10 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第19回福岡国際母子総合研究シンポジウム・第6回市民公開講座  ( 福岡 ) 2008.9 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回EBウイルス感染症研究会  ( 東京 ) 2008.3 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第69回日本血液学会  ( 仙台 ) 2007.12 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第18回福岡国際母子総合研究シンポジウム・第5回市民公開講座  ( 福岡 ) 2007.9 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第14回小児再生不良性貧血治療研究会  ( 名古屋 ) 2007.6 - 2011.5

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship) International contribution

    ( 東京 ) 2006.12 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第37回日本小児感染症学会  ( 高知 ) 2006.11 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第68回日本血液学会  ( 福岡 ) 2006.9 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第16回EBウイルス感染症研究会  ( 東京 ) 2006.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第15回EBウイルス感染症研究会  ( 東京 ) 2005.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第46回日本小児血液学会  ( 京都 ) 2004.10 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第11回小児再生不良性貧血治療研究会  ( 名古屋 ) 2004.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第45回日本小児血液学会  ( 金沢 ) 2003.10 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第13回EBウイルス感染症研究会  ( 東京 ) 2003.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第44回日本小児血液学会  ( 東京 ) 2002.10 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第43回日本小児血液学会  ( 北九州 ) 2001.9 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第8回小児再生不良性貧血治療研究会  ( 東京 ) 2001.6 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第11回EBウイルス感染症研究会  ( 東京 ) 2001.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第42回日本小児血液学会  ( 大阪 ) 2000.9 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第41回日本小児血液学会  ( 東京 ) 1999.9 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第6回小児再生不良性貧血治療研究会  ( 名古屋 ) 1999.6 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第9回EBウイルス感染症研究会  ( 東京 ) 1999.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第8回EBウイルス感染症研究会  ( 東京 ) 1998.5 - Present

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    Type:Competition, symposium, etc. 

  • 座長(Chairmanship)

    第7回EBウイルス感染症研究会  ( 東京 ) 1997.5 - Present

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    Type:Competition, symposium, etc. 

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Research Projects

  • 小児期に発症する心筋炎の病因と心筋障害機構の解析

    Grant number:22H03043  2022 - 2024

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 慢性活動性EBV病の疾患レジストリ情報に基づく病型別根治療法の確立

    2022 - 2023

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Principal investigator  Grant type:Contract research

  • 血液凝固異常症等に関する研究

    2020 - 2022

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 新生児から成人までに発症する特発性血栓症の診療アルゴリズムの確立

    2020 - 2022

    国立研究開発法人日本医療研究機構 令和2年度難治性疾患実用化研究事業

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    Authorship:Principal investigator  Grant type:Contract research

  • 慢性活動性EBV感染症と類縁疾患の疾患レジストリ情報に基づいた診療ガイドライン改定

    2020 - 2021

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 先天性骨髄不全症の登録システムの構築と診断基準・重症度分類・診断ガイドラインの確立に関する研究

    2019 - 2021

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 高機能データベースを用いた先天性心疾患患者のための包括的看護支援システムの構築

    Grant number:18H03083  2018 - 2020

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 間葉系細胞の採取および細胞評価

    Grant number:17102-TTZ4K-A01-0005  2017 - 2021

    日本学術振興会・文部科学省  科学研究費助成事業  新学術領域研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 臍帯血を用いた新生児・小児の肝再生細胞療法の研究

    Grant number:17H04229  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 臍帯血を用いた新生児・小児の肝再生細胞療法の研究

    2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 臍帯血を用いた新生児・小児の肝再生細胞療法の研究

    Grant number:17H04229  2017 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 新生児・乳児に発症する特発性血栓症の病態解明および治療管理法と根治療法の確立に関する研究

    2017 - 2019

    国立研究開発法人日本医療研究機構 平成29年度難治性疾患実用化研究事業

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    Authorship:Principal investigator  Grant type:Contract research

  • 慢性活動性EBウイルス感染症と類縁疾患の疾患レジストリとバイオバンクの構築

    2017 - 2019

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 血液凝固異常症等に関する研究

    2017 - 2019

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 小児期から移行期・成人期を包括する希少難治性慢性消化器疾患の医療政策に関する研究

    2017 - 2019

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • ヒルシュスプルング病および類縁疾患における乳歯幹細胞による病因解明と新規治療開発

    Grant number:16H02682  2016 - 2019

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 先天性骨髄不全症の診断基準・重症度分類・診療ガイドラインの確立に関する研究

    2016 - 2018

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 亜急性硬化性全脳炎の病態解明とバイオマーカーの確立

    Grant number:15K09654  2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 亜急性硬化性脳炎の病態解明とバイオマーカーの確立

    2015 - 2017

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 先天性赤芽球癆(Diamond-Blackfan貧血)の新規原因遺伝子の同定と病態解明に関する研究

    2015 - 2017

    国立研究開発法人日本医療研究機構 平成29年度難治性疾患実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 稀少小児遺伝性血液疾患に対する次世代シークエンサーを利用した診断システムの開発に関する研究

    2015 - 2017

    国立研究開発法人日本医療研究機構 平成29年度難治性疾患実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 慢性活動性EBウイルス感染症とその類縁疾患の診断・治療効果評価の向上を目指したEBウイルスDNA 量のエビデンスの構築

    2015 - 2017

    国立研究開発法人日本医療研究機構 平成29年度難治性疾患実用化研究事業

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 新型インフルエンザは気管支喘息の発症因子か?

    Grant number:15K19619  2015 - 2016

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 小児外科領域の難治性疾患における脱落乳歯幹細胞を用いた新規治療法の開発

    Grant number:25253094  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 免疫低下を認める小児に対する肺炎球菌ワクチンおよびヒブワクチンの有効性の検討

    Grant number:25461598  2013 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 血球貪食症候群における包括的治療法確立に関する研究

    Grant number:24591577  2012 - 2015

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 血球貪食症候群における包括的治療法確立に関する研究

    Grant number:24591577  2012 - 2014

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 先天性代謝異常症及び凝固異常症に対する乳歯幹細胞を用いた肝再生療法の開発

    Grant number:23659618  2011 - 2012

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 先天性角化不全症の効果的診断方法の確立と治療ガイドラインの作成に関する研究(H22-難治-一般-210)

    2010

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • ゆりかごネットプロジェクト

    2009.8 - 2014.3

    文部科学省周産期医療環境整備(人材養成)事業 

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    Authorship:Collaborating Investigator(s) (not designated on Grant-in-Aid) 

  • 難治性EBウイルス関連疾患の病因と治療に関する研究

    Grant number:21591388  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 難治性EBウイルス関連疾患の病因と治療に関する研究

    Grant number:21591388  2009 - 2011

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 先天性赤芽球癆 (Diamond Blackfan貧血)の効果的診断法の確立に関する研究 (22141101 )

    2009 - 2011

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • 血球貪食症候群の病態・診療研究

    2009 - 2011

    厚生労働科学研究費補助金 (厚生労働省)

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    Authorship:Coinvestigator(s)  Grant type:Contract research

  • JSPS-NRCT International coauthorship

    2007.4 - 2011.3

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    Authorship:Coinvestigator(s) 

  • 慢性活動性EBウイルス感染症の感染細胞特性と治療に関する研究

    Grant number:19591255  2007 - 2009

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 慢性活動性EBウイルス感染症の感染細胞特性と治療に関する研究

    Grant number:19591255  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 22q11.2欠失症候群における制御性T細胞の解析

    2007 - 2008

    科学研究費助成事業  若手研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 慢性活動性EBウイルス感染症の感染細胞特性と治療に関する研究

    Grant number:19591255  2007 - 2008

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 20歳未満に発症する血液疾患と小児がんに関する疫学研究

    2006.9 - 2028.6

    日本小児血液・がん学会 

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    Authorship:Principal investigator 

  • 日本学術振興会(JSPS) アジア研究教育拠点事業 造血障害の研究・教育交流拠点の形成とアジア血液学の創出

    2006 - 2010

    科学研究費助成事業  国際学術研究

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 22q11.2欠失症候群における末梢T細胞の解析

    Grant number:17790708  2005 - 2006

    科学研究費助成事業  若手研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 先天性赤芽球癆の病因および病態解析

    2005 - 2006

    小児医学研究助成(財団法人母子健康協会)

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    Authorship:Principal investigator  Grant type:Contract research

  • 先天性造血不全症の病因・病態解析と治療法の確立

    Grant number:15591114  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 先天性造血不全症の病因・病態解析と治療法の確立

    Grant number:15591114  2003 - 2004

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 家族性血球貪食症候群の病態解析と責任遺伝子の同定

    Grant number:14370248  2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 家族性血球貪食症候群の病態解析と責任遺伝子の同定

    2002 - 2003

    日本学術振興会  科学研究費助成事業  基盤研究(B)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • リンパ増殖性疾患(lymphoproliferative disease : LPD)における活性化T細胞の解析

    Grant number:13670814  2001 - 2002

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • リンパ増殖性疾患(lymphoproliferative disease: LPD)における活性化T細胞の解析

    2001 - 2002

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 慢性活動性EBウイルス感染症とEBウイルス関連リンパ増殖症におけるT細胞の解析

    Grant number:11670766  1999 - 2000

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 慢性活動性EBウイルス感染症とEBウイルス関連リンパ増殖症におけるT細胞の解析

    1999 - 2000

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • ヒトγδT細胞機能の免疫分子生物学的解析

    Grant number:10470179  1998 - 1999

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • ヒトγδT細胞機能の免疫分子生物学的解析

    Grant number:10470179  1998 - 1999

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Authorship:Coinvestigator(s)  Grant type:Scientific research funding

  • 組織球増殖性疾患の病態解析と骨髄移植を含めた治療プロトコールに関する研究

    Grant number:08770565  1996

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 組織球増殖性疾患の病態解析と骨髄移植を含めたプロトコールに関する研究

    1996

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 化膿性髄膜炎の免疫学的解析:デキサメサゾン療法の有用性と炎症サイトカインの検討

    Grant number:07770585  1995

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 化膿性髄膜炎の免疫学的解析:デキサメサゾン療法の有用性と炎症性サイトカインの検討

    1995

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 悪性細網症とその類縁疾患における炎症性サイトカインの解析

    Grant number:06770569  1994

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 悪性細網症とその類縁疾患における炎症性サイトカインの解析

    1994

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 炎症性サイトカインの生体防御機構における役割とその臨床的意義

    Grant number:05770538  1993

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 炎症性サイトカインの生体防御機構における役割とその臨床的意義

    1993

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 炎症性サイトカインの感染防御機構における意義

    Grant number:04770619  1992

    日本学術振興会  科学研究費助成事業  基盤研究(C)

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    Grant type:Scientific research funding

  • 炎症性サイトカインの感染防御機構における意義

    1992

    科学研究費助成事業  奨励研究(A)

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    Authorship:Principal investigator  Grant type:Scientific research funding

  • 小児再生不良性貧血治療研究会

    1991.1

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    Authorship:Coinvestigator(s) 

  • EBウイルス感染症研究会

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    Authorship:Principal investigator 

▼display all

Class subject

  • 医学研究特論Ⅱ

    2022.4 - 2023.3   Full year

  • 医学研究特論Ⅱ

    2022.4 - 2023.3   Full year

  • 医学研究特論Ⅰ

    2021.4 - 2022.3   Full year

  • 医学研究特論Ⅱ

    2020.4 - 2021.3   Full year

  • 受胎・成長・発達 こどもの診かた

    2020.4 - 2020.9   First semester

  • 血液 小児の血液疾患(1) 総論・貧血 (2)リンパ腫・固形腫瘍・移植

    2019.10 - 2020.3   Second semester

  • 臨床医学Ⅰ「臨床実習」

    2019.4 - 2020.3   Full year

  • 臨床実習Ⅱ「クリニカルクラークシップ」

    2019.4 - 2020.3   Full year

  • 受胎・成長・発達 こどもの診かた・乳幼児の成長、発達、栄養

    2019.4 - 2019.9   First semester

  • 血液 小児の血液疾患(1)総論・貧血

    2018.10 - 2019.3   Second semester

  • 血液 小児の血液疾患(3)小児白血病

    2018.10 - 2019.3   Second semester

  • 臨床実習Ⅱ「クリニカルクラークシップ」

    2018.4 - 2019.3   Full year

  • 臨床医学Ⅰ「臨床実習」

    2018.4 - 2019.3   Full year

  • 受胎・成長・発達 こどもの診かた・乳幼児の成長、発達、栄養

    2018.4 - 2018.9   First semester

  • 受胎・成長・発達 川崎病

    2018.4 - 2018.9   First semester

  • 受胎・成長・発達 血液系の発達と疾患

    2018.4 - 2018.9   First semester

  • 臨床実習Ⅱ「クリニカルクラークシップ」

    2017.4 - 2018.3   Full year

  • 臨床医学Ⅰ「臨床実習」

    2017.4 - 2018.3   Full year

  • 受胎・成長・発達 川崎病

    2017.4 - 2017.9   First semester

  • 受胎・成長・発達 こどもの診かた・乳幼児の成長、発達、栄養

    2017.4 - 2017.9   First semester

  • 血液 小児の血液疾患(1)

    2016.10 - 2017.3   Second semester

  • 系統医学Ⅴ「血液」

    2016.10 - 2017.3   Second semester

  • 臨床医学Ⅰ「臨床実習」

    2016.4 - 2017.3   Full year

  • 臨床実習Ⅱ「クリニカルクラークシップ」

    2016.4 - 2017.3   Full year

  • 系統医学Ⅵ(受胎・成長・発達)

    2016.4 - 2016.9   First semester

  • 遺伝学 遺伝病の診断・予防と治療(1)

    2011.10 - 2012.3   Second semester

  • 血液免疫データ解析

    2010.4 - 2011.3   Full year

  • 新生児血液データ解析

    2010.4 - 2011.3   Full year

  • 新生児血液データ解析

    2010.4 - 2011.3   Full year

  • 九州大学 医歯薬合同講義 「病態制御学Ⅳ-②」 周産期・成長発達医学概論1 小児の血液疾患

    2010.4 - 2010.9   First semester

  • 九州大学 医歯薬合同講義 「病態制御学Ⅳ-②」 周産期・成長発達医学概論1 小児の血液疾患

    2010.4 - 2010.9   First semester

  • 「総合講義」 周産期チーム医療入門

    2009.4 - 2009.9   First semester

  • 「総合講義」 周産期チーム医療入門

    2009.4 - 2009.9   First semester

  • 「総合講義」 医工学入門

    2008.4 - 2008.9   First semester

  • 臨床医学群(血液)「小児の血液疾患3」

    2005.10 - 2006.3   Second semester

  • 臨床医学群(血液)「小児の血液疾患3」

    2005.10 - 2006.3   Second semester

▼display all

FD Participation

  • 2019.8   Title:令和元年度医学部医学科・生命科学科FD

  • 2018.10   Title:医学部医学科・生命科学科FD(ファカルティ・ディベロップメント)

  • 2016.8   Role:Participation   Title:医学部医学科・生命科学科FD(ファカルティ・ディベロップメント)

    Organizer:Undergraduate school department

  • 2009.8   Role:Participation   Title:医学部FD

    Organizer:Undergraduate school department

  • 2002.8   Role:Participation   Title:第3回九州大学医学部医学教育ワークショップ

    Organizer:Undergraduate school department

Visiting, concurrent, or part-time lecturers at other universities, institutions, etc.

  • 2024  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2023  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2022  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2021  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2020  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2019  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  愛媛大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2018  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2017  愛媛大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2017  山口大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2017  京都府立医科大学大学院  Classification:Part-time lecturer  Domestic/International Classification:Japan 

  • 2016  愛媛大学医学部  Classification:Part-time lecturer  Domestic/International Classification:Japan 

▼display all

Outline of Social Contribution and International Cooperation activities

  • <診療活動>
    九州大学病院小児科の外来および病棟にて小児の血液、免疫疾患を中心に診療している。再生不良性貧血、血球貪食症候群、リンパ増殖性疾患、血友病ほかの凝固異常症、免疫不全症、SLEや若年性関節リウマチなどの膠原病を含め幅広い領域の患児を診療している。また、平成27年より田川市立病院小児科にて外来を担当している(月1回)。福岡県福岡医療介護部 がん感染症疾病対策課よりの委嘱で福岡県難病医療連絡協議会委員を受任、がん・疾病対策のための福岡県事業に協力・連携している。当科より福岡および周辺地区の急患センターへ医員派遣を行い、休日および夜間の診療地域医療に参画している。平成18年よりアジア研究教育拠点事業(JSPS)においてマヒドン大学(バンコク・タイ)と血液学に関する教育研究活動をすすめている。



    <受託研究>
    グラン再生不良性貧血 キリン
    PUPStudy 日赤
    アドベイト バクスター

Social Activities

  • 平成28年度 第19回警固英知の会 「こどもたちの未来~小児科学の進歩から」

    福岡市立警固中学校(福岡市中央区)  2016.11

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 日本医学会総会関連対話学習

    福岡市東区舞松原小学校  2003.2

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    Audience: Infants, Schoolchildren, Junior students, High school students

    Type:Seminar, workshop

  • 再生つばさの会九州地区学習会と講演会 骨髄異形成症候群の治療および小児血液疾患の病態と治療

    再生つばさの会  福岡市  2000.10

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    Audience: General, Scientific, Company, Civic organization, Governmental agency

    Type:Lecture

Media Coverage

  • 「拡大新生児スクリーニング」についてご紹介 TV or radio program

    九州朝日放送  2023.7

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    「拡大新生児スクリーニング」についてご紹介

  • 医療 いのち「小児がん経験者、6割が晩期合併症」 2023年5月28日 Newspaper, magazine

    西日本新聞  2023.5

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    医療 いのち「小児がん経験者、6割が晩期合併症」 2023年5月28日

  • 「子どものはしか」(#941) ・国内では減っているけれど… ・子どものはしかの注意点 ・ワクチン接種のポイント TV or radio program

    KBC九州朝日放送  2017.2

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    「子どものはしか」(#941)
    ・国内では減っているけれど…
    ・子どものはしかの注意点
    ・ワクチン接種のポイント

  • すこやかカフェ 九州・山口発 小児がん〈下〉親の会、悩み支え合う 2016年8月28日 Newspaper, magazine

    読売新聞  2016.8

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    すこやかカフェ 九州・山口発
    小児がん〈下〉親の会、悩み支え合う
    2016年8月28日

  • 日本医学会総会関連対話学習 福岡市東区舞松原小学校6年生への講義 ”病気と遺伝と環境と” Newspaper, magazine

    読売、毎日  2003.2

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    日本医学会総会関連対話学習
    福岡市東区舞松原小学校6年生への講義
    ”病気と遺伝と環境と”

Activities contributing to policy formation, academic promotion, etc.

  • 2018.11   日本小児感染症学会

    第50回日本小児感染症学会総会・学術集会 会長
    第9回アジア小児感染症学会との共同開催

  • 2017.1 - 2021.1   厚生労働省医薬・生活衛生局

    薬事・食品衛生審議会臨時委員〈医薬品第一部会〉

Travel Abroad

  • 2019.9

    Staying countory name 1:Indonesia   Staying institution name 1:Grand Kawanua Convention Center, MANADO, Indonesia

  • 2018.5

    Staying countory name 1:Canada   Staying institution name 1:Metro Toronto Convention Centre

  • 2018.5

    Staying countory name 1:Korea, Republic of   Staying institution name 1:The-K Hotel

  • 2016.11

    Staying countory name 1:Korea, Republic of   Staying institution name 1:Daejeon Convention Center

Specialized clinical area

  • Biology / Medicine, Dentistry and Pharmacy / Internal Medicine / Pediatrics

    小児血液・免疫

Clinician qualification

  • Preceptor

    The Japanese Society of Hematology

  • Specialist

    The Japanese Society of Hematology

  • Specialist

    Japan Pediatric Society

  • 理事長

    日本産婦人科・新生児血液学会

  • 理事長

    日本小児血液・がん学会

  • Preceptor

    日本小児感染症学会

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Year of medical license acquisition

  • 1984

Notable Clinical Activities

  • CAEBV/EBV-LPDの診断と治療 小児造血不全症の診断と治療