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Toyoki Maeda Last modified date:2022.04.14

Associate Professor / Kyushu University Hospital

Graduate School
Undergraduate School

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Academic Degree
MD. PhD.
Country of degree conferring institution (Overseas)
Field of Specialization
Internal Medicine, Geriatrics
Total Priod of education and research career in the foreign country
Outline Activities
A purpose of my research is to elucidate a new somatic DNA recombination mechanism at developmental stages in the central nervous system.
Another research is to aim to identify genomic regions of which instability is associated with aging, including telomeric regions.
I have focused on telomeric structural changes as aging- or disease-associated genomic alterations of aged people with chronic diseases for the last 5 years.
From 2012 academic year, I conducted a large-scale epidemiological research with a questionnaire of clinical history and hot spa-bathing in collaboration with the Beppu city office and the Beppu Medical Association. I have published this epidemiological study in Sciecne Reports (18; 133: 2018). I introduced this epidemiological study and therapeutic effects for severe chronic pains of fibromyalgia syndrome at 26 th international congress of applied psychology in Paris in July 2014, at 10th FENS Forum in Copenhagen in July 2016, and in the memorial lecture of 30th anniversary of sister city-ship between Rotorua and Beppu in New Zealand in June 2017.
Research Interests
  • somatic DNA recombination in brain
    keyword : genomic DNA rearrangement in brain, extrachromosomal circular DNA
    1987.04In this research, a genomic region which undergoes somatic DNA recombination is identified by analyzing extrachromosomal circular DNA molecules in mouse embryonic brain..
  • Detection of Genomic Aging
    keyword : Telomere, Aging
  • Prevention of Metabolic Diseases by Hot Spring Bathing
    keyword : Hot Spring
  • Pelotherapeutic approach for chronic pain
    keyword : pelotherapy
Academic Activities
1. Maeda T, Mimori K, Suzuki S, Horiuchi T, Makino N, Preventive and promotive effects of habitual spa-bathing on the elderly in Japan., Scientific Reports, 10.1038/s41598-017-18488-3., 8, 1, 133, 2018.01.
2. Maeda T, Kurita R, Yokoo T, Tani K, Makino N., Telomerase inhibition promotes an initial step of cell differentiation of primate embryonic stem cell, Biochem. Biophys. Res. Commun., 407, 3, 491-494, 2011.04.
3. Maeda, Toyoki; Oyama, Jun-ichi; Koyanagi, Masamichi; Higuchi, Yoshihiro; Sasaki, Makoto; Mimori, Koshi; Arima Takahiro and Makino Naoki. , The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events., Aging Male, 14, 2, 21-26, 2011.03.
4. T Maeda, J-I Oyama, M Sasaki, T Arima, and N Makino., The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension., J Nutr Health Aging , 15, 3, 240-244, 2011.03.
5. T. Maeda, J-I. Oyama, Y. Higuchi, Y. Nishiyama, Y. Kudo, T Yamori, T. Nakazono, T. Arima, K. Mimori, N.Makino., The physical ability of Japanese female elderly with cerebrovascular disease correlates to the telomere length and subtelomeric methylation status in their peripheral blood leukocytes., Gerontology, 57, 2, 137-143, 2011.02.
6. T. Maeda, J-I Oyama, M. Sasaki, Y. Nishiyama, Y. Kudo, T. Yamori, T. Nakazono, T. Arima and N. Makino., The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with the telomere length in their peripheral blood leukocytes., Aging Clin Exp Res, 23, 1, 22-28, 2011.02.
7. T. Maeda, J-I. Oyama, Y. Higuchi, T. Arima, K. Mimori, N. Makino., The correlation between the telomeric parameters and the clinical laboratory data in the patients with brain infarct and metabolic disorders., J Nutr Health Aging, 14, 9, 793-797, 2010.09.
8. Toyoki Maeda, Jing Zhi Guan, Jun-ichi Oyama, Yoshihiro Higuchi, Naoki Makino., Aging-associated alteration of subtelomeric methylation in Parkinson’s disease. , Journals Gerontol, Series A, Biological Sci and Med Sci, 64巻、9号、949−955ページ, 2009.09.
9. Toyoki Maeda, Jing Zhi Guan, Jun-ichi Oyama, Yoshihiro Higuchi, Naoki Makino, Age-related changes in subtelomeric methylation in the normal Japanese population. , the Journals of Gerontology, Series A, Biological Science and Medical Science , 64巻, 426-434ページ, 2009.02.
10. Maeda, T., Chijiiwa, Y., Tsuji, H., Sakoda, S., Tani, K and Suzuki, T., Somatic DNA recombination yielding circular DNA and deletion of a genomic region in embryonic brain., Biochem. Biophys. Res. Commun, 10.1016/j.bbrc.2004.05.093, 319, 4, 1117-1123, Vol 319: 1117-1123., 2004.06.
11. Maeda T, Sugiyama H. Tani Y. Miyake Y. Oka Y. Komori T. Ogawa H.Soma T. Minami Y. Sakato N. and Kishimoto S., The DJh complex remains active in recombination to Vh segments after the loss of mu-chain expression in mu-positive pre-B cells., Journal of Immunology, Vol 166: p607-612, 1989.01.
12. Maeda, Toyoki. Sugiyama, H. Tani, S. Miyake, Y. Oka, H. Ogawa, T. Komori, T. Soma, T and Kishimoto, S., Start of mu-chain production by further two-step rearrangements of immunoglobulin heavy chain genes on one chromosome from a DJh/DJh complex formation, Journal of Immunology, Vol.138, p2305-2309, 1987.04.
1. Toyoki Maeda, The medical effects of hot spring bathing, Beppu-Rotorua Sister City Partnership 30th Anniversary Preoject, 2017.06.
2. 前田 豊樹, The effects of hot spring bathing (pelotherapy) for chronic pains with fibromyalgia syndrome, 10th FENS Forum, 2016.07.
3. 前田 豊樹, The effects of hot spring bathing for mental and physical health., 28th International Conference of Applied Psychology, 2014.07.
Other Educational Activities
  • 2015.10.
  • 2015.06.
  • 2013.06.