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Yasunari Sakai Last modified date：2024.06.27

Associate Professor / Department of Pediatrics, Graduate School of Medical Sciences
Department of Clinical Medicine
Faculty of Medical Sciences


Administration Post
Other


Homepage
https://kyushu-u.elsevierpure.com/en/persons/yasunari-sakai
　Reseacher Profiling Tool　Kyushu University Pure
https://pediatr.kyushu-u.ac.jp/
Academic Degree
M.D., Ph.D.
Country of degree conferring institution (Overseas)
No
Field of Specialization
Pediatric Neurology
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
1. Research: Molecular mechanisms of neuro-developmental disorders.
2. Education: Scientific training for graduate and undergraduate students
3. Clinical and social activity: Child neurology & Emergency service
Research
Research Interests
  • Systemic diseases in childhood and human-specific development of the postnatal brain function
    keyword : Autism spectrum disorder, Epilepsy, Brain-Immune interaction, Interactome, Alternative splicing, Molecular signaling
    2011.04The purpose of this study is to establish the therapeutic models of the target-specific gene corrections with non-viral procedures. Chemically-modified single-stranded oligonucleotides have been shown to activate the endogenous reactions of homologous recombination in the recipient cells, resulting in the site-specific corrections of the mutated genes. We have attempted to develop more efficient systems with various nano-particles and a novel transfection instrument, gas-plasma generator..
Academic Activities
Reports
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Papers
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1. Yasunari Sakai, Masato Furuichi, Masayuki Takahashi, Masaki Mishima, Shigenori Iwai, Masahiro Shirakawa, Yusaku Nakabeppu, A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1., J Biol Chem, 10.1074/jbc.M110566200, 277, 10, 8579-87, 2002.03.
2. Yasunari Sakai, Chad A. Shaw, Brian C. Dawson, Diana V. Dugas, Zaina Al-Mohtaseb, David E. Hill, Huda Y. Zoghbi, Protein Interactome Reveals Converging Molecular Pathways Among Autism Disorders, Sci Transl Med, 10.1126/scitranslmed.3002166, 3, 86, 86ra49, 2011.06.
3. Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, Sanefuji M, Ishizaki Y, Torisu H, Nakabeppu Y, Suzuki A, Takada H, Hara T, Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice., Sci Rep, 10.1038/srep22991, 6, 22991-22991, 2016.03.
4. Sakai Y, Fukai R, Matsushita Y, Miyake N, Saitsu H, Akamine S, Torio M, Sasazuki M, Ishizaki Y, Sanefuji M, Torisu H, Shaw CA, Matsumoto N, Hara T, De Novo Truncating Mutation of TRIM8 Causes Early-Onset Epileptic Encephalopathy., Ann Hum Genet, 10.1111/ahg.12157, 80, 4, 235-240, 2016.07.
5. Satoshi Akamine, Sayaka Okuzono, Hiroyuki Yamamoto, Daiki Setoyama, Noriaki Sagata, Masahiro Ohgidani, Takahiro A Kato, Tohru Ishitani, Hiroki Kato, Keiji Masuda, Yuki Matsushita, Hiroaki Ono, Yoshito Ishizaki, Masafumi Sanefuji, Hirotomo Saitsu, Naomichi Matsumoto, Dongchon Kang, Shigenobu Kanba, Yusaku Nakabeppu, Yasunari Sakai, Shouichi Ohga, GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons., FASEB J, 10.1096/fj.202001113R, 34, 12, 16601-16621, 2020.12.
6. Yasutaka Nakashima, Yasunari Sakai, Yumi Mizuno, Kenji Furuno, Keiichi Hirono, Shinichi Takatsuki, Hiroyuki Suzuki, Yoshihiro Onouchi, Tohru Kobayashi, Kazuhiro Tanabe, Kenji Hamase, Tomofumi Miyamoto, Ryohei Aoyagi, Makoto Arita, Kenichiro Yamamura, Tamami Tanaka, Hisanori Nishio, Hidetoshi Takada, Shouichi Ohga, Toshiro Hara, Lipidomics links oxidized phosphatidylcholines and coronary arteritis in Kawasaki disease., Cardiovasc Res, 10.1093/cvr/cvz305, 117, 1, 96-108, 2021.01.
7. Michiko Torio, Mariko Iwayama, Toru Sawano, Hirosuke Inoue, Masayuki Ochiai, Ryoji Taira, Kousuke Yonemoto, Yuko Ichimiya, Yuri Sonoda, Momoko Sasazuki, Yoshito Ishizaki, Masafumi Sanefuji, Kenichi Yamane, Hiroshi Yamashita, Hiroyuki Torisu, Ryutaro Kira, Toshiro Hara, Shigenobu Kanba, Yasunari Sakai, Shouichi Ohga, Neurodevelopmental Outcomes of High-Risk Preterm Infants A Prospective Study in Japan, Neurol Clin Pract, 10.1212/CPJ.0000000000000920, 11, 5, 398-405, 2021.10.
8. Sayaka Okuzono, Fumihiko Fujii, Yuki Matsushita, Daiki Setoyama, Yohei Shinmyo, Ryoji Taira, Kousuke Yonemoto, Satoshi Akamine, Yoshitomo Motomura, Masafumi Sanefuji, Takeshi Sakurai, Hiroshi Kawasaki, Kihoon Han, Takahiro A Kato, Hiroyuki Torisu, Dongchon Kang, Yusaku Nakabeppu, Yasunari Sakai, Shouichi Ohga, Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice., Neurosci Res, 10.1016/j.neures.2023.03.001, 193, 13-19, 2023.03.
9. Yuko Ichimiya, Pin Fee Chong, Yuri Sonoda, Vlad Tocan, Mitsuru Watanabe, Hiroyuki Torisu, Ryutaro Kira, Toshiyuki Takahashi, Jun-Ichi Kira, Noriko Isobe, Yasunari Sakai, Shouichi Ohga, Long-lasting pain and somatosensory disturbances in children with myelin oligodendrocyte glycoprotein antibody-associated disease., Eur J Pediatrics, 10.1007/s00431-023-04989-z, 182, 7, 3175-3185, 2023.04.
10. Reina Ogata, Kyoko Watanabe, Pin Fee Chong, Jun Okamoto, Yoshihiro Sakemi, Toshinori Nakashima, Takuro Ohno, Hiroyuki Nomiyama, Yuri Sonoda, Yuko Ichimiya, Hirosuke Inoue, Masayuki Ochiai, Hironori Yamashita, Yasunari Sakai, Shouichi Ohga, Divergent neurodevelopmental profiles of very-low-birth-weight infants., Pediatr Res, 10.1038/s41390-023-02778-w, 2023.08.
11. Kousuke Yonemoto, Fumihiko Fujii, Ryoji Taira, Masahiro Ohgidani, Katsuhide Eguchi, Sayaka Okuzono, Yuko Ichimiya, Yuri Sonoda, Pin Fee Chong, Hironori Goto, Hikaru Kanemasa, Yoshitomo Motomura, Masataka Ishimura, Yuhki Koga, Keita Tsujimura, Takao Hashiguchi, Hiroyuki Torisu, Ryutaro Kira, Takahiro A Kato, Yasunari Sakai, Shouichi Ohga, Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells., Clin Immunol, 10.1016/j.clim.2023.109756, 255, 109756-109756, 2023.10.
Presentations
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Membership in Academic Society
  • The Japanese Society of Child Neurology
  • The Japan Society of Human Genetics
  • The Japan Epilepsy Society
  • Japan Pediatric Society
  • The American Society of Human Genetics
  • Society for Neuroscience
  • The Molecular Biology Society of Japan


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