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Masako Hosoi Last modified date:2023.06.23

Lecturer / Department of Psychosomatic Medicine, Graduate School of Medical Sciences
Psychosomatic Medicine
Kyushu University Hospital

Graduate School
Undergraduate School
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Administration Post

 Reseacher Profiling Tool Kyushu University Pure
Academic Degree
Country of degree conferring institution (Overseas)
Field of Specialization
Psychosomatic Medicine, Argology, Neuroscience
ORCID(Open Researcher and Contributor ID)
Total Priod of education and research career in the foreign country
Outline Activities
Psychosomatic Research on Pain, Psychosomatic epidemiological study in Hisamaya, Translational Research on Pain and Micloglia, Development of Assessment Methods for Pain, Development of Multidisciplinary Approach of Chronic Pain, Oxytocin and attachment, Development of Projection Method describing psychosocial factors (PRISM and Circle Drawing), Nightmare and chronic pain, Development of Neurofeedback using EEG
Research Interests
  • The effect of medical distrast on chronic pain practice
    keyword : medical distrast, attachment
  • Development of projection methods describing psychosomatic factors (PRISM and Circle Drawing)
    keyword : PRISM, Circle Drawing, Psychosocial factors, Projection method
  • Development of Neurofeedback using EEG for patients with chronic pain
    keyword : Neurofeedback, EEG, chronic pain
  • The Effects of Nightmare on Chronic Pain and Central Sensitization
    keyword : nightmre, chronic pain, central sensitizatino, trauma, sleep stage, body motion senser
  • Translational research on chronic pain: Elucidation of the pathology and the development of the evaluation methods from the aspects of psycho-neuro-immunology
    keyword : chronic pain, psychology, microglia
  • The cohort study on chronic pain
    keyword : retrospective study, pain questionnaire
  • Brain imaging study on chronic pain
    keyword : Default mode network, VBM
  • Clinical and epidemiological research on the relationship between life-style diseases and alexithymia, nurturing style and positive feelings
    keyword : epidemiology; nurturing; life-style disease; alexithymia
  • Study of catastrophizing and alexithymia on chronic pain
    keyword : chronic pain, catastrophizing, alexithymia
  • The development of the assessment of chronic pain
    keyword : pain, questionnaire
    2003.04Development of the Assessment Methods of Chronic Pain.
Academic Activities
1. Tesio V, Goerlich KS, Hosoi M, Castelli L, Alexithymia: State of the Art and Controversies. Clinical and Neuroscientific Evidence., Frontiers Media, DOI: 10.3389/978-2-88963-106-3, Isbn: 978-2-88963-106-3, 2019.09, [URL].
2. Hori T, Oka T, Hosoi M, Abe M, Oka K, Biphasic modulation of pain by hypothalamic cytokines.
In: Saade, NE, Apkarian, AV, and Jabbur, SJ (ed) : Pain and Neuroimmune Interactions
, Kluwer Academic/Plenum Publishers, New York, pp. 171-189, 2000.01.
3. Hosoi, M.: Recent advance of molecular genetics in the psychosomatic medicine. In Modern Psycosomatic Medicine. Kubo C., Nakai, Y. and Nozoe, S. (Eds). Nagai-shoten, Tokyo, in press.
4. Komiyama, H. and Hosoi, M.: Chronic pain. In Kubo, C. (ed) :Standard textbook of psychosomatic medicine. Igakusyoin, Tokyo: 178-185, 1996..
5. Hosoi, M.: Psychopharamcotherapy. In Luban-Plozza B, Pöldinger W, Kröger F (ed) :Practice in Psychosomatic Medicine, Schpringer-Verlag, Tokyo: 243-279, 1995 (Translation).
1. Pain and disbelief: the importance in the care of affective component of pain.
2. Psychosomatic approach for difficult cases of patients with chronic pain.
3. Chronic Pain-in the borderline between somatic disorder and psychiatric disorder-
4. Psychosomatic Treatment for Chronic Pain and Cingulate Cortex
-from Bench to Bed-.
5. Muraoka M, Komiyama H, Hosoi M, Mine K, Kubo C, Psychosomatic treatment of phantom limb pain with post-traumatic stress disorder: a case report, Pain 66 (2,3), 385-388, 1996.01.
1. Tomioka, M., Hosoi, M., Okuzawa, T., Anno, K., Iwaki, R., Kawata, H., Kubo, C. & Sudo, N., The effectiveness of Pictorial Representation of Illness and Self Measure (PRISM) for the assessment of the suffering and quality of interpersonal relationships of patients with chronic pain, BioPsychoSocial Medicine, doi: 10.1186/s13030-021-00223-0., 15, 1, PMID: 34801076, 2022.01.
2. Koji Fujimoto, Masako Hosoi, Ryoko Katsuki, Toshio Matsushima, Keitaro Matsuo, Tomohiro Nakao, Nobuyuki Sudo, Takahiro A. Kato, Psychological traits of patients with depression comorbid with chronic pain: Are Complaint and Competitive tendency related to pain?, Frontiers in Psychiatry, section Psychological Therapy and Psychosomatics, Manuscript ID: 825422, 2022.01.
3. Mao Shibata, Tomoyuki Ohara, Masako Hosoi, Hata Jun, Daigo Yoshida, Naoki Hirabayashi, Yukiko Morisaki, Taro Nakazawa, Akane Mihara, Takuya Nagata, Emi Oishi, Kozo Anno, Nobuyuki Sudo, Toshiharu Ninomiya, Emotional loneliness is associated with a risk of dementia in a general Japanese older population: the Hisayama Study, The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 10.1093/geronb/gbaa196, 2020 Nov 10, gbaa196., 2020.11, [URL], Objectives: To investigate the association of loneliness and its component subscales with the risk of dementia in a general Japanese older population.

Method: A total of 1,141 community-dwelling Japanese residents aged ≥65 years without dementia were prospectively followed up for a median 5.0 years. We evaluated any loneliness and its component subscales-namely, social and emotional loneliness-by using the 6-Item de Jong Gierveld Loneliness Scale. Cox proportional hazards models were used to estimate hazard ratios (HRs) of each loneliness type on the risk of dementia controlling for demographic factors, lifestyle factors, physical factors, social isolation factors, and depression.

Results: During the follow-up, 114 participants developed dementia. The age- and sex-adjusted incidence rate of dementia was significantly greater in participants with any loneliness and emotional loneliness than those without. The multivariable-adjusted HRs (95% confidence intervals) of participants with any loneliness and emotional loneliness on incident dementia were 1.61 (1.08-2.40) and 1.65 (1.07-2.54), respectively, as compared to those without. However, there was no significant association between social loneliness and dementia risk. In subgroup analyses of social isolation factors, excess risks of dementia associated with emotional loneliness were observed in participants who had a partner, lived with someone, or rarely communicated with relatives or friends, but such association was not significant in participants who had no partner, lived alone, or frequently communicated with friends or relatives.

Discussion: The present study suggested that loneliness, especially emotional loneliness, was a significant risk factor for the development of dementia in the general older population in Japan.

Keywords: alienation; communication; epidemiology; prospective cohort study; social exclusion..
4. Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M., Parenting style during childhood is associated with the development of chronic pain and a patient's need for psychosomatic treatment in adulthood., Medicine 99 (29) 2020 7.17, p e21230, 2020.07.
5. Valentina Tesio, Katharina S. Goerlich, Masako Hosoi, Lorys Castelli, Editorial
Alexithymia: State of the art and controversies. Clinical and neuroscientific evidence, Frontiers in Psychology, 10.3389/fpsyg.2019.01209, 10, MAY, 2019.01.
6. Ohgidani M, Kato TA, Hosoi M, Tsuda M, Hayakawa K, Hayaki C, Iwaki R, Sagata N, Hashimoto R, Inoue K, Sudo N, Kanba S, Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells, Scientific Reports, 10.1038/s41598-017-11506-4, 19;7(1):11882, 2017.09, [URL].
7. Chie Hayaki, Kozo Anno, Mao Shibata, Rie Iwaki, Hiroshi Kawata, Nobuyuki Sudo, Masako Hosoi, Family dysfunction A comparison of chronic widespread pain and chronic localized pain, MEDICINE, 10.1097/MD.0000000000005495, 95, 49, 2016.12.
8. Shibata M, Ninomiya T, Anno K, Kawata H, Iwaki R, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M, Perceived inadequate care and excessive overprotection during childhood are associated with greater risk of sleep disturbance in adulthood: the Hisayama Study, BMC PSYCHIATRY, 10.1186/s12888-016-0926-2, 16, 2016.07.
9. Anno K, Shibata M, Ninomiya T, Iwaki R, Kawata H, Sawamoto R, Kubo C, Kiyohara Y, Sudo N, Hosoi M, Paternal and maternal bonding styles in childhood are associated with the prevalence of chronic pain in a general adult population: the Hisayama Study, BMC PSYCHIATRY, 10.1186/s12888-015-0574-y, 15, 2015.07.
10. Shibata M, Ninomiya T, Jensen MP, Anno K, Yonemoto K, Makino S, Iwaki R, Yamashiro K, Yoshida T, Imada Y, Kubo C, Kiyohara Y, Hosoi M, Sudo N, Alexithymia is Associated with Greater Risk of Chronic Pain and Negative Affect and with Lower Life Satisfaction in a General Population: The Hisayama Study, PLOS ONE, 10.1371/journal.pone.0090984, 9, 3, 2014.03.
11. Makino Seiko, Jensen Mark P., Arimura Tatsuyuki, Obata Tetsuji, Anno Kozo, Iwaki Rie, Kubo Chiharu, SUDO Nobuyuki, Hosoi Masako, Alexithymia and Chronic Pain The Role of Negative Affectivity, The Clinical Journal of Pain, 10.1097/AJP.0b013e3182579c63, 29, 4, 354-361, 2013.04.
12. Toshiyuki Yoshida, Ivan R. Molton, Mark P. Jensen, Tomoyasu Nakamura, Tatsuyuki Arimura, Chiharu Kubo, Masako Hosoi, Cognitions, metacognitions, and chronic pain, Rehabilitation Psychology, 10.1037/a0028903, 57, 3, 207-213, 2012.08, Purpose: Although the content of thoughts has received a considerable amount of attention in pain research, the importance of thought processes (metacognitions) has received less attention. Method: One hundred twenty-nine individuals with muscular dystrophy and chronic pain completed measures assessing metacognitions and frequency of both catastrophizing and pain control beliefs. Results: Greater use of reappraisal and distraction metacognitions were associated with more perceived control over pain, whereas greater use of worry and punishment metacognitions were associated with more catastrophizing. Conclusions/Implications: The current findings indicate that metacognitions are associated with both pain control beliefs and catastrophizing and therefore may play an important role in the development or maintenance of pain-related cognitive content thought to influence patient functioning. Research is needed to determine whether treatments that encourage changes in both metacognitions and cognitive content are more effective than treatments that focus on cognitive content alone..
13. Rie Iwaki, Tatsuyuki Arimura, Mark P. Jensen, Tomoyasu Nakamura, Koji Yamashiro, Seiko Makino, Tetsuji Obata, Nobuyuki Sudo, Chiharu Kubo, Masako Hosoi, Global Catastrophizing vs Catastrophizing Subdomains
Assessment and Associations with Patient Functioning, Pain Medicine (United States), 10.1111/j.1526-4637.2012.01353.x, 13, 5, 677-687, 2012.05, Objective. The primary objectives of the current study were to 1) confirm the three-factor model of the Pain Catastrophizing Scale (PCS) items in a Japanese sample and 2) identify the catastrophizing subdomain(s) most closely associated with measures of pain and functioning in a sample of individuals with chronic pain. Design. This was based on a cross-sectional observational study. Setting. This study was conducted in a university-based clinic. Patients. One hundred and sixty outpatients with chronic pain participated in this study. Outcome Measures. Patients completed the PCS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale; 30 patients completed the PCS again between 1 and 4 weeks later. Results. Confirmatory factor analysis supported a three-factor structure of the Japanese version of the PCS, and univariate and multivariate associations with validity criterion supported the validity of the measure. Catastrophic helplessness was shown to make a unique contribution to the prediction of pain intensity, pain interference and depression, and catastrophic magnification made a unique contribution to the prediction of anxiety. Conclusions. The findings support the cross-cultural generalizability of the three-factor structure of the PCS and indicate that the PCS-assessed catastrophizing subdomains provide greater explanatory power than the PCS total score for understanding pain-related functioning. Wiley Periodicals, Inc..
14. Tatsuyuki Arimura, Masako Hosoi, Yoshihiro Tsukiyama, Toshiyuki Yoshida, Daiki Fujiwara, Masanori Tanaka, Ryuichi Tamura, Yasunori Nakashima, Nobuyuki Sudo, Chiharu Kubo, Pain Questionnaire Development Focusing on Cross-Cultural Equivalence to the Original Questionnaire
The Japanese Version of the Short-Form McGill Pain Questionnaire, Pain Medicine, 10.1111/j.1526-4637.2012.01333.x, 13, 4, 541-551, 2012.04, Objectives. The present study aimed to develop a Japanese version of the Short-Form McGill Pain Questionnaire (SF-MPQ-J) that focuses on cross-culturally equivalence to the original English version and to test its reliability and validity. Design. Cross-sectional design. Method. In study 1, SF-MPQ was translated and adapted into Japanese. It included construction of response scales equivalent to the original using a variation of the Thurstone method of equal-appearing intervals. A total of 147 undergraduate students and 44 pain patients participated in the development of the Japanese response scales. To measure the equivalence of pain descriptors, 62 pain patients in four diagnostic groups were asked to choose pain descriptors that described their pain. In study 2, chronic pain patients (N=126) completed the SF-MPQ-J, the Long-Form McGill Pain Questionnaire Japanese version (LF-MPQ-J), and the 11-point numerical rating scale of pain intensity. Correlation analysis examined the construct validity of the SF-MPQ-J. Results. The results from study 1 were used to develop SF-MPQ-J, which is linguistically equivalent to the original questionnaire. Response scales from SF-MPQ-J represented the original scale values. All pain descriptors, except one, were used by >33% in at least one of the four diagnostic groups. Study 2 exhibited adequate internal consistency and test-retest reliability, with the construct validity of SF-MPQ-J comparable to the original. Conclusion. These findings suggested that SF-MPQ-J is reliable, valid, and cross-culturally equivalent to the original questionnaire. Researchers might consider using this scale in multicenter, multi-ethnical trials or cross-cultural studies that include Japanese-speaking patients. Wiley Periodicals, Inc...
15. Koji Yamashiro, Tatsuyuki Arimura, Rie Iwaki, Mark P. Jensen, Chiharu Kubo, Masako Hosoi, A multidimensional measure of pain interference
Reliability and validity of the pain disability assessment scale, Clinical Journal of Pain, 10.1097/AJP.0b013e318204858a, 27, 4, 338-343, 2011.05, Objective: Measuring outcomes across multiple domains is essential for an adequate understanding of chronic pain and the effects of pain treatment. Pain interference reflects the negative effects of pain on functioning, and is recognized as a critical outcome domain. The Pain Disability Assessment Scale (PDAS) contains items that assess the negative effects of pain on broad spectrum pain interference domains. The purpose of this study was to examine the factor structure, reliability, and validity of the PDAS. Methods: One hundred sixty-four Japanese patients with chronic pain were administered the PDAS, the Brief Pain Inventory, and the Hospital Anxiety and Depression Scale. Results: The findings support a 3 factor structure of the PDAS items, as well as a high level of internal consistency of the scales created from these factors (Cronbach αs range: 0.87 to 0.95). Validity of the 3 scales was supported through their significant associations, in hypothesized directions, with measures of pain intensity, anxiety, depression, and another established measure of pain interference, as well as differences in PDAS scores between patients with versus without back pain. Conclusions: The PDAS may be useful when researchers or clinicians require a multidimensional measure of the effects of pain on a patients life..
16. Masako Hosoi, Ivan R. Molton, Mark P. Jensen, Dawn M. Ehde, Silvia Amtmann, Sarah O'Brien, Tatsuyuki Arimura, Chiharu Kubo, Relationships among alexithymia and pain intensity, pain interference, and vitality in persons with neuromuscular disease
Considering the effect of negative affectivity, Pain, 10.1016/j.pain.2010.02.012, 149, 2, 273-277, 2010.05, Alexithymia, the inability to identify or label emotions, has been shown to be associated with pain in patients with a number of chronic pain conditions. We sought to: (1) replicate this association in samples of persons with chronic pain secondary to neuromuscular disease, (2) extend this finding to other important pain-related measures, and (3) to determine whether relationships among alexithymia and study variables existed after controlling for negative affect. One hundred and twenty-nine individuals with muscular dystrophy and chronic pain were administered measures of alexithymia (Toronto Alexithymia Scale, TAS-20), pain intensity (0-10 NRS), pain interference (Brief Pain Inventory Interference scale), mental health (SF-36 Mental Health scale; as a proxy measure of negative affect) and vitality (SF-36 Vitality scale). Higher TAS scores were associated significantly with higher pain intensity and interference, and less vitality. Although the strengths of these associations were reduced when mental health was used as a control, the associations between the Difficulty Identifying Feelings scale and vitality, and the Externally Oriented Thinking and Total TAS scales and pain intensity remained statistically significant. The findings replicate and extend previous findings concerning the associations between alexithymia and important pain-related variables in a sample of persons with chronic pain and neuromuscular disease. Future research is needed to determine the extent to which the associations are due to (1) a possible causal effect of alexithymia on patient functioning that is mediated via its effects on negative affect or (2) the possibility that alexithymia/outcome relationships reflect response bias caused by general negative affectivity..
17. Wei Xiong, Masako Hosoi, Bon Nyeo Koo, Li Zhang, Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization, Molecular Pharmacology, 10.1124/mol.107.039149, 73, 2, 314-322, 2008.02, Converging evidence has suggested that anandamide (AEA), an endogenous agonist of cannabinoid (CB) receptors, can directly interact with certain types of ligand-gated ion channels (LGICs). However, little is known about the molecular and cellular mechanisms of AEA-induced direct effects on LGICs. Here, we report that AEA inhibited the function of serotonin-gated ion channels (5-HT3A) expressed in Xenopus laevis oocytes and human embryonic kidney 293 cells in a manner that was dependent on the steady-state receptor density at the cell surface. The magnitude of AEA inhibition was inversely correlated with the expression levels of receptor protein and function. With increasing surface receptor expression, the magnitude of AEA inhibition decreased. Consistent with this idea, pretreatment with actinomycin D, which inhibits transcription, decreased the amplitude of current activated by maximal concentrations of 5-hydroxytryptamine (5-HT) and increased the magnitude of AEA inhibition. AEA did not significantly alter 5-HT3A receptor trafficking. However, AEA accelerated 5-HT3A receptor desensitization time in a concentration-dependent manner without significantly changing receptor activation and deactivation time. The desensitization time was correlated with the AEA-induced inhibiting effect and mean 5-HT current density. Applications of 5-hydroxyindole and nocodazole, a microtubule disruptor, significantly slowed 5-HT3A receptor desensitization and reduced the magnitude of AEA inhibition. These observations suggest that 5-HT3 receptor density at the steady state regulates receptor desensitization kinetics and the potency of AEA-induced inhibiting effect on the receptors. The inhibition of 5-HT3 receptors by AEA may contribute to its physiological roles in control of pain and emesis..
18. Hayashi H, Mine K, Hosoi M, Tsuchida O, Handa M, Kinukawa N, Andou K, Kubo C, Comparison of the esophageal manometric characteristics of idiopathic and reflux-associated esophageal spasm: evaluation by 24-hour ambulatory esophageal motility and pH monitoring., Digestive Diseases and Sciences, 10.1023/B:DDAS.0000004514.91064.7f, 48, 11, 2124-2131, 48 (11) : 2124-2131, 2003.11.
19. Yoshio Kanemitsu, Masako Hosoi, Ping Jun Zhu, Forrest F. Weight, Robert W. Peoples, Joseph S. McLaughlin, Li Zhang, Dynorphin A inhibits NMDA receptors through a pH-dependent mechanism, Molecular and Cellular Neuroscience, 10.1016/S1044-7431(03)00214-8, 24, 3, 525-537, 2003.01, Dynorphin A (DynA), an endogenous agonist of κ-opioid receptors, has also been reported to directly interact with the NMDA receptor. DynA inhibition of NMDA receptor function has been suggested to be involved in its neuroprotective action during ischemic and acidic conditions. However, the effect of external pH on DynA inhibition of the NMDA receptor has not been reported. Here, we show that DynA inhibition of the NMDA receptor is dependent on extracellular pH over the range of pH 6.7-8.3, and the inhibition by 10 μM DynA increases at low pH by three- to four-fold in hippocampal neurons and in Xenopus oocytes expressing NR1-1a/2B subunits. Molecular studies showed that the interacting site for DynA on the NMDA receptor is distinct from that of proton or redox sites. Peptide mapping demonstrated important contributions of positively charged residues and specific structural organization of the peptide to the potency of DynA inhibition. Thus, DynA inhibits NMDA receptors through an allosteric mechanism, which is pH dependent and involves the specific structural features of the peptide..
20. Hosoi M, Oka T, Abe M, Hori T, Yamamoto H, Mine K, Kubo C, Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats, Pain, 10.1016/S0304-3959(99)00105-0, 83, 2, 221-227, 83 (4) : 221-227, 1999.11.
21. Hosoi M, Oka T, Hori T, Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca, Pain, 10.1016/S0304-3959(97)03380-0, 71, 3, 303-311, 71 : 303-311, 1997.07.
22. Arimura, T., Komiyama, H. and Hosoi, M.: Pain Disability Assessment Scale (PDAS) -A simplified scale for clinical use-. Japanese Journal of Behavior Therapy. 23(1): 7-15, 1997..
23. H. Komiyama, M. Muraoka, K. Mine, H. Hayakawa, M. Hosoi, T. Nakagawa, K. Kodama, C. Kubo, Psychosomatic study on chronic pain. Consideration of the treatment and prognosis, Japanese Journal of Psychosomatic Medicine, 35, 4, 287-297, 1995.01, In the department of psychosomatic medicine, Kyushu University, a chronic pain patient is defined as 'a patient whose pain complaint or social or occupational impairment is in excess of what would be expected from the underlying organic pathology.' We have treated patients of this category by means of various kinds of somatic, psychologic and psychiatric methods. In this paper, 40 cases who had been treated for chronic pain on an inpatient basis in our institute were studied regarding applied treatment methods, their effect, treatment outcome and factors affecting prognosis. The results are as follows: 1) All the subjects were prescribed several kinds of antidepressants and minor tranquilizers as pharmacological treatment with the aim of alleviating the pain. 2) The somatic approach consisted of nerve block, laser and silver spike point electro therapy, all of which were applied to the patients with neurogenic pain. We feel that these methods also have some psychological effect. 3) Some behavioral methods were applied, such as autogenic training (AT), graded exercise quota and other operant techniques (time-out, prompting and token economy). AT helped the patients to effectively cope with pain caused by depressive disorders and psychophysiological mechanisms. Graded exercise quota was applied to teach patients to effectively manage avoidance pain behaviors to fearful situations. Other operant techniques were necessary for controlling more excessive pain behaviors. 4) In addition, some patients received either family therapy or counseling. The former was effective both for patients with depressive disorders whose family system acted as a psychological burden and for patients with conversion disorders who utilized their pain as a communication method. Counseling was necessitated for patients whose interpersonal cognitions were distorted or whose social skills were immature. 5) Treatment outcomes were evaluated from following four aspects; the strength of the subjective pain, the degree of the impairment of daily activity or role functioning and the dependence on medical treatments. Evaluation of the short-term outcome at 1-month after discharge showed 3 excellent, 14 good, 19 fair and 4 poor cases. Evaluation of the long-term outcome at 6-12 months revealed 5 excellent, 18 good, 10 fair and 7 poor cases. 6) Examination of factors affecting prognosis suggested that the most important was to analyse the patients' pain problems from a detailed multiphasic view and to institute the appropriate treatment on the basis of that analysis. On the basis of these results, the possibility was discussed as to how to apply various methods systemically, such as somatic approach, pharmacological treatment, behavioral therapy, family therapy and other psychotherapy, depending on the patients' pathogenesis..
24. H. Komiyama, M. Muraoka, K. Mine, H. Hayakawa, M. Hosoi, T. Nakagawa, K. Kodama, C. Kubo, Psychosomatic study on chronic pain. Clinical features of chronic pain and reconsideration on its definition, Japanese Journal of Psychosomatic Medicine, 34, 6, 489-498, 1994.01, In the Department of Psychosomatic Medicine, Kyushu University, a chronic pain patient is defined on the basis of our clinical experiences and reviews of associated literatures as 'the patient whose pain complaint or social or occupational impairment is in excess of what would be expected from the underlying organic pathology'. We assessed the pathogenesis of each patient in this category based on a multidimensional evaluation including organic, functional and psychiatric diagnosis, as well as behavioral analysis and family analysis. In this paper, 40 cases who had been treated as having chronic pain on inpatient basis in our institute were studied regarding their clinical features. The results are as follows: 1) Before the first visit to us, they underwent various treatments at many institutes and several admissions. In addition, some cases underwent one or more operations for alleviation of the pain in vain. 2) An operation for a physical disease, a psychosocial stressor, an injury and a disease with no need of operation were considered to have functioned as the precipitating factor for the pain. Many patients developed their pain from an experience of a noxious stimulus as a trigger. 3) psychiatric diagnosis made according to DSM-III-R showed that conversion disorder and major depression were the two most common disorders and that a few cases had hypochondriasis or social phobia. These psychiatric disorders led to the pain of the patients. As accompanying psychiatric diseases, there existed psychoactive substance abuse, panic disorder, factitious disorder or others on Axis I and some kinds of personality disorder on Axis II. 4) As functional diseases, there were deafferentation pain, reflex sympathetic dystrophy, tension-type headache, irritable bowel syndrome, non-ulcer dyspepsia and aerophagia. 5) The comparison between the characteristics of depressive disorder and those of conversion disorder revealed that patients with depressive disorder were significantly more related to experience of a noxious stimulus. 6) Behavioral analysis suggested that operant learning mainly played a causative role in the pain behaviors of many cases. 7) In the operant pain patients, 4 types of consequence in their environment acted as reward contingent on their pain behaviors. These included solicitous response, avoidance of reality, avoidance of conflict and maintenance of family system. These results suggest that there exists a complicated pathogenesis consisting of various factors behind persistent and intractable pain. Therefore, it is necessary to evaluate chronic pain patients on the basis of detailed psychosomatic assessment. It is thus considered to be important to attempt to understand the psychological, social and existentional meanings of each patient's pain..
1. Masako Hosoi, Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
in Large-Scale Research Consortia in Pain Session, IASP Virtual Series on Pain & Expo: Innovation in Research and Education, 2020.11.
2. Masako Hosoi, Mao Shibata, Kozo Anno, Toshiharu Ninomiya, Hiroshi Kawata, Rie Iwaki, Ryoko Sawamoto, Chiharu Kubo, Yutaka Kiyohara, Nobuyuki Sudo, Parenting style during childhood is associated with the development of chronic pain and the need for psychosomatic treatment in adulthood: a case-control study, IASP 2018 17TH WORLD CONGRESS ON PAIN, 2018.09.
3. Anno K, Hayaki C, Nishihara T, Iwaki R, Shibata M, Sudo N, Hosoi M, The prevalence of fibromyalgia according to adult attachment style in patients with chronic pain., IASP 2018 17TH WORLD CONGRESS ON PAIN, 2018.09.
4. Shibata M, Hosoi M, Ohara T, Hirabayashi N, Anno K, Yoshida D, Kanba S, Sudo N, Ninomiya T, The association between progression of dementia and loneliness in an older general population from the viewpoint of social and emotional aspects: the Hisayama Study., The Asian College of Psychosomatic Medicine (ACPM) 2018, 2018.08.
5. Masako Hosoi, Masahiro Ohgitani, Takahiro A. Kato, Rie Iwaki, Chie Hayaki, Nobuyuki Sudo, Kanba S, TNFα-Response is Associated with the Clinical Pain Outcomes of Fibromyalgia Patients: An Evaluation Done with Human Blood-Induced MicrogliaLike Cells(iMG), 16th World Congress on Pain(第16回世界疼痛学会), 2016.09.
6. Chronic pain and Alexithymia : the Research History and Future.
7. Abdominal pain and emotion-the role of insular cortex-.
8. Nociception and pain-Alexithymia and pain experience-
9. Psychosomatic approach for difficult cases of patients with chronic pain.
Membership in Academic Society
  • Japanese Association for Study of Pain
Educational Activities
Clinical Teaching for Medical Students to see Outpatients,
Clinical Teaching for Medical Students to see Inpatients,
Teaching in the Clinical Clerkship and Basic Research,
Lecturer in Medical Seminar and Orientation Lecture on Psychosoamtic Medicine held in the Dept.of Psychosomatic Medicine in Kyushu University Hospital
Professional and Outreach Activities
Colaboratory Study with researchers of Department of Psychiatrics in the University of Vienna, Vienna, Austria (2006-)

Colaboratory Study with researchers of Department of Rehabilitation in the University of Washington, Seattle, USA (2005-)

Colaboratory Study with researchers of National Institute on Alcohol Abuse and Alcoholism (NIAAA),
National Institutes of Health (NIH), USA (1997-)

Engagement of the study on psychosomatic diseases funded by Japanese Ministry of Health, Welfare and Labor.