Kyushu University Academic Staff Educational and Research Activities Database
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Masahiro Mizoguchi Last modified date:2021.05.31

Associate Professor / Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
Neurological Institute
Faculty of Medical Sciences


Graduate School
Undergraduate School
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Homepage
https://kyushu-u.pure.elsevier.com/en/persons/masahiro-mizoguchi
 Reseacher Profiling Tool Kyushu University Pure
http://www.med.kyushu-u.ac.jp/ns/
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University .
Phone
092-642-5524
Fax
092-642-5526
Academic Degree
Medical science
Country of degree conferring institution (Overseas)
No
Field of Specialization
Neurosurgery
Total Priod of education and research career in the foreign country
00years00months
Outline Activities
Molecular genetic analysis of brain tumors
Research
Research Interests
  • Evaluation of immuno-microenvironment of glioma by liquid biopsy
    keyword : glioma, liquid biopsy, immune-microenvironment, cancer genome medicine
    2021.04~2021.05.
  • Liquid Biopsy for brain tumor
    keyword : brain tumor, glioma, liquid biopsy
    2015.04~2020.07.
  • Molecular genetic analysis of brain tumors
    keyword : brain tumor, genetics, signaling pathway, molecular target therapy
    2001.10~2011.03.
  • MicroRNA regulation for "stemness" in brain tumor stem cell
    keyword : Brain tumor stem cell (BTSC) microRNA
    2010.06~2013.03Implication of microRNA in brain tumor stem cells.
  • Expression of miroRNA and alteration of signaling pathways in brain tumor stem cells
    keyword : Brain tumor stem cell (BTSC) microRNA
    2005.06~2009.03Implication of microRNA in brain tumor stem cells.
Academic Activities
Reports
1. Mizoguchi M, Kuga D, Guan Y, Hata N, Nakamizo A, Yoshimoto K, Sasaki T., Loss of heterozygosity analysis in malignant gliomas., Brain Tumor Pathol, 2011.07, Despite recent advances in the diagnosis and treatment of glioblastomas, patient outcomes for these highly malignant tumors remain poor. Research into the molecular pathology of glioblastoma has uncovered various genetic changes that contribute to malignancy. Some of the identified molecular markers--such as loss of heterozygosity (LOH) on chromosome 1p/19q and chromosome 10, O6-methylguanine methyltransferase promoter hypermethylation, and mutation of isocitrate dehydrogenase-1--may help to predict patient outcomes. Indeed, LOH analysis is an effective approach to classify malignant gliomas. Genome-wide analyses have revealed that the extent and pattern of LOH regions may have important implications for the clinical course of the disease. As the genetic underpinnings of malignant gliomas are complex and varied, careful selection of the methods for genetic analysis in the clinic is important. The fundamental principles of each assay need to be understood to allow careful selection of practically useful methods. This review summarizes recent developments in the molecular analysis of malignant glioma..
2. Koji Yoshimoto, Masahiro Mizoguchi, Nobuhiro Hata, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, Molecular biomarkers of glioblastoma: current targets and clinical implications, 2012.10.
3. Masahiro Mizoguchi, Yanlei Guan, Koji Yoshimoto, Nobuhiro Hata, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, MicroRNAs in Human Malignant Gliomas, 2012.10.
4. Koji Yoshimoto, Masahiro Mizoguchi, Nobuhiro Hata, Hideki Murata, Ryusuke Hatae, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, Complex DNA repair pathways as possible therapeutic targets to overcome temozolomide resistance in glioblastoma, 2012.12.
5. Masahiro Mizoguchi, Yanlei Guan, Koji Yoshimoto, Nobuhiro Hata, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, Clinical implications of microRNAs in human glioblastoma, Frontiers in Oncology, 2013.02.
Papers
1. Mori M, Chiba T, Nakamizo A, Kumashiro R, Murata M, Akahoshi T, Tomikawa M, Kikkawa Y, Yoshimoto K, Mizoguchi M, Sasaki T, Hashizume M:, Intraoperative visualization of cerebral oxygenation using hyperspectral image data: a two-dimensional mapping method, Int J Comput Assist Radiol Surg, 9, 6, 1059-1072, 2014.11.
2. Kikkawa Y, Matsuo S, Hokama M, Kurogi R, Nakamizo A, Mizoguchi M, Sasaki T, Gene Expression Profiling and Bioinformatic Analysis of Rabbit Basilar Artery after Experimental Subarachnoid Hemorrhage, J Neurol Neurophysiol, 5, 210, 2014.01.
3. Xinlong Ma, Koji Yoshimoto, Yanlei Guan, Nobuhiro Hata, Masahiro Mizoguchi, Noriaki Sagata, Hideki Murata, Daisuke Kuga, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma, 10.1093/neuonc/nos145, 14, 9, 1153-1162, 2012.09.
4. Masahiro Mizoguchi, Koji Yoshimoto, Xilong Ma, Yanlei Guan, Nobuhiro Hata, TOSHIYUKI AMANO, Akira Nakamizo, Satoshi O Suzuki, Toru Iwaki, Tomio Sasaki, Molecular characteristics of glioblastoma with 1p/19q co-deletion, 10.1007/s10014-012-0107-z, 29, 3, 148-153, 2012.07.
Presentations
1. Masahiro Mizoguchi, Koji Yoshimoto, Nobuhiro Hata, TOSHIYUKI AMANO, Akira Nakamizo, Tomio Sasaki, Clinical Implications of Loss of Heterozygosity and IDH Mutation in Malignant Glioma, The 4th International Symposium of Brain Tumor Pathology, 2012.05.
2. Koji Yoshimoto, Masahiro Mizoguchi, Nobuhiro Hata, Tomio Sasaki, Diagnostic significance of microRNA and gene expression in glioma patients, The 4th International Symposium of Brain Tumor Pathology, 2012.05.
3. Assessment of 1p/19q deletion in malignant gliomas.
4. Treatment strategy of malignant gliomas based on molecular analysis.
5. Analysis of IDH1 mutation and LOH status in human glioma.
6. Clinical implication of molecular pathology in malignant glioma.
7. Loss of heterozygosity analysis of malignant gliomas using the PCR with multiple microsatellite markers.
8. Molecular pathology of malignant glioma.
9. Molecular pathology of malignant glioma.
Membership in Academic Society
  • The Japan Neurosurgical Society
  • The Japanese Congress of Neurological Surgery
  • The Japan Society for Neuro-Oncology
  • The Japanese Congress for Brain Tumor Surgery
  • The Japan Society of Brain Tumor Pathology
  • The Japan Stroke Society
  • Japanese Society on Surgery for Cerebral Stroke
  • Japan Society for CNS Computed Imaging
  • The Japan Society of Molecular Neurosurgery
Educational
Educational Activities
Brain tumor: basic science (molecular patholoby, molecular biology), and clinical sturdy (surgical treatment, chemotherapy)
Social
Professional and Outreach Activities
Cooperation with the community and contribution to society
International cooperation.