| 津田 誠（つだ まこと） | データ更新日：2024.04.12 |
教授 ／
薬学研究院
臨床薬学部門
薬理学分野
| 1. | 津田誠, 脊髄反射と脊髄/中枢性感作, 「疼痛医学」教科書制作研究会, 2020.03. |
| 2. | Tsuda Makoto, Microglia in the CNS and neuropathic pain, Springer New York LLC, 10.1007/978-981-13-1756-9_7, 77-91, 2018.01, [URL], Neuropathic pain occurring after peripheral nerve injury is not simply a consequence of temporal continuity of acute nociceptive signals, but rather of maladaptive nervous system function. Over the past decades, a body of literature has provided evidence for the necessity and sufficiency of microglia, the tissue-resident macrophages of the central nervous system, for nerve injury-induced alterations in synaptic function. Recent studies have also revealed active roles for microglia in brain regions important for emotion and memory. In this chapter, I highlight recent advances in our understanding of the mechanisms that underlie the role of spinal and brain microglia in neuropathic pain, with a focus on how microglia are activated and alter synaptic function. I also discuss the therapeutic potential of microglia from recent advances in the development of new drugs targeting microglia, which may facilitate translation from the bench to bedside.. |
| 3. | 津田誠, 神経障害性疼痛のメカニズム解析とそれによる創薬について, 一般社団法人 医薬品医療機器レギュラトリーサイエンス財団, 2017.11. |
| 4. | 津田誠, 神経障害性疼痛における最新メカニズムと創薬への応用, 技術情報協会, 2017.08. |
| 5. | 津田 誠, グリアと神経障害性痛（痛みのScience&Practice）, 文光堂, 2014.05. |
| 6. | Masuda Takahiro et al., Intrathecal infusion of microglia cells., Springer, 2013.09. |
| 7. | Masuda Takahiro et al., Lentiviral transduction of cultured microglia., Springer, 2013.09. |
| 8. | 井上 和秀, 津田 誠, 神経障害性疼痛, 克誠堂出版, pp24-32「脊髄・二次ニューロンの可塑的変化と神経障害性疼痛」, 2012.10. |
| 9. | 津田誠，井上和秀, 慢性疼痛における薬剤選定と治療薬開発, 技術情報協会, 2010.06. |
| 10. | 津田誠，井上和秀, 実践行動薬理学：脊髄ミクログリアのATP受容体を介する新しい神経障害性疼痛メカニズム, 株式会社金芳堂, 2010.03. |
| 11. | Toulme E, Tsuda M, Khakh BS, Inoue K, On the role of ATP-gated P2X receptors in acute, inflammatory and neuropathic pain, CRC Press, 2009.11. |
| 12. | M. Tsuda, K. Inoue, The nociceptive membrane, Current Topics in Membrane 57, Chapter 9. P2X receptors in sensory neurons., Elsevier, pp277-310, (2006), 2006.09. |
| 13. | Inoue K, Tsuda M, Koizumi S., Chronic pain and microglia: the role of ATP., Novartis Found Symp. 261, 55-64; discussion 64-67, 149-54 (2004)., 2004.05. |
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